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Review of Sleep Medicine E-Book

Review of Sleep Medicine E-Book

Alon Y. Avidan

(2017)

Additional Information

Book Details

Abstract

Successfully review sleep medicine whether you plan to improve your sleep medicine competency skills or prepare for the Sleep Medicine Certification Exam with this expanded review-and-test workbook that includes more than 1,400 interactive questions and answers. Now in full color throughout, Review of Sleep Medicine, 4th Edition, by Dr. Alon Y. Avidan, features a new, high-yield format designed to help you make the most of your study time, using figures, polysomnography tracings, EEG illustrations, sleep actigraphy and sleep diaries, tables, algorithms, and key points to explain challenging topics.

  • Includes concise summaries of all aspects of sleep medicine clinical summaries from epidemiology, pathophysiology, clinical features, diagnostic techniques, treatment strategies and prognostic implications.
  • Provides a library of assessment questions with comprehensive explanations to help you identify the reasoning behind each answer and think logically about the problems.
  • Offers the expertise of a multidisciplinary global team of experts including sleep researchers, multispecialty sleep clinicians, and educators. The unique strength of this educational resource is its inclusion of all sleep subspecialties from neurology to pulmonary medicine, psychiatry, internal medicine, clinical psychology, and Registered Polysomnographic Technologists.
  • Perfect for sleep medicine practitioners, sleep medicine fellows and trainees, allied health professionals, nurse practitioners, sleep technologists, and other health care providers as review tool, quick reference manual, and day-to-day resource on key topics in sleep medicine.
  • Provides a highly effective review with a newly condensed, outline format that utilizes full-color tables, figures, diagrams, and charts to facilitate quick recall of information.
  • Includes new and emerging data on the function and theories for why we sleep, quality assessment in sleep medicine, and benefits and risks of sleep-inducing medications.
  • Contains new chapters on sleep stage scoring, sleep phylogenic evolution and ontogeny, geriatric sleep disorders and quality measures in sleep medicine.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Review of Sleep Medicine i
Copyright Page iv
Contributors v
Foreword ix
Preface x
Table Of Contents xii
Abbreviations xiv
I Foundation of Sleep Medicine 1
1 Introduction to Sleep Medicine 1
Organization of the Review of Sleep Medicine 1
Brief Historical Overview 1
Ontogeny of Sleep 3
Definition of Sleep 3
Proposed Biological Functions of Sleep 4
Dreams 4
Sleep Architecture Sleep Stages 4
Prevalence of Sleep Disorders 7
Circadian Clock Systems and Sleep Habits 7
Sleep Requirements 7
Sleep Duration Consensus 7
Symptoms of Sleep Disorders 9
Excessive Daytime Sleepiness 9
Insomnia 10
Abnormal and Complex Nocturnal Behaviors 10
International Classification of Sleep Disorders 11
Insomnia 11
Sleep-Related Breathing Disorders 11
Central Disorders of Hypersomnolence 11
Circadian Rhythm Sleep–Wake Disorders 12
Parasomnias 12
Sleep-Related Movement Disorders 12
Other Sleep Disorders 12
Isolated Symptoms and Normal Variants 12
Appendices 12
Key Tools for the Evaluation of Sleep Disorder 12
Laboratory Tests for the Diagnosis and Monitoring of Sleep Disorders 12
Laboratory Tests for Suspected Seizure Disorders 12
Imaging Studies 12
Miscellaneous Tests 13
Specific Indications for Overnight Polysomnography 13
Suggested Reading 13
References 13.e1
II Highlights of Normal Sleep 14
2 Sleep Phylogenic Evolution and Ontogeny 14
Rapid Eye Movement Sleep 14
Marine Mammals 14
The Neurochemistry of Electroencephalogram Control 17
Birds 17
Land Mammals 17
Phylogenetic Correlates of Sleep Duration 18
Clinical Significance 22
Sleep in Preindustrial People 23
Conclusions 23
Suggested Reading 24
References 24.e1
3 Normal Human Sleep-Wake Patterns 25
What Is Sleep? 25
Role of Sleep 25
Normal Sleep and Wake Timing 25
Normal Sleep Patterns 26
Normal Sleep Duration 28
Gender Differences 30
Sleep and Menses 30
Sleep and Pregnancy 30
Sleep and Menopause 31
Suggested Reading 31
References 31.e1
4 Highlights of Sleep Neuroscience 32
Introduction 32
Regulation of Arousal 32
Monoaminergic Neurons 32
Dopamine Neurons 33
Cholinergic Neurons 34
Glutamate 34
Hypocretin/Orexin 35
Sleep-Promoting Mechanisms 35
Preoptic Hypothalamic Neurons 35
Melanin Concentrating Hormone Neurons 36
Rostral Medullary Neurons 37
Sleep Regulatory Substances 37
Adenosine 37
Cytokines 37
Rapid Eye Movement Sleep-Generating Mechanisms 37
Brainstem GABA-Glutamate Neuronal Interactions 37
Cholinergic and Monoaminergic Modulation of Rapid Eye Movement Sleep 38
Forebrain-Brainstem Interactions and the Generation of the Nonrapid Eye Movement/Rapid Eye Movement Cycle 38
Hypocretin/Orexin 38
Preoptic Neurons 39
Melanin-Concentrating Hormone Neurons 39
Suggested Reading 39
References 39.e1
5 Normal Sleep Physiology (Including Respiratory and Cardiac Physiology) 40
Introduction 40
Changes in the Central Nervous System During Sleep 40
Clinical Relevance 41
Changes in the Autonomic Nervous System and Its Changes During Sleep 41
Alterations in Autonomic Nervous System Activity During Sleep (Box 5.2) 41
Clinical Relevance 42
Control of Respiration During Sleep and Wakefulness 43
Changes in Breathing During Sleep 44
Upper Airway Reflexes and Resistance 45
Sleep-Related Changes in the Upper Airway and Related Muscles 45
Mechanism of Muscle Hypotonia in Nonrapid Eye Movement Sleep 46
Mechanism of Muscle Atonia or Hypotonia in Rapid Eye Movement Sleep 46
Clinical Relevance 47
Changes in the Cardiovascular System During Sleep 47
Heart Rate and Rhythm 47
Cardiac Output 48
Systemic and Pulmonary Arterial Pressure 48
Systemic Blood Flow and Peripheral Vascular Resistance 48
Systolic Blood Pressure 48
Cerebral Blood Flow 48
Clinical Relevance 48
Changes in Endocrine Secretions During Sleep 49
Circadian Changes in Endocrine Function 49
Adrenocorticotrophic Hormone and Cortisol 49
Growth Hormone 49
Prolactin 50
Thyroid Stimulating Hormone 50
Gonadotropic Hormone 50
Renin-Angiotensin-Aldosterone Activity 50
Parathormone Secretion 50
Antidiuretic Hormone 50
Melatonin 50
Clinical Relevance 51
Changes in the Alimentary System During Sleep 51
Esophageal Function 51
Gastric Acid Secretion and Gastric Motility 52
Intestinal Motility and Secretions 52
Clinical Relevance 52
Changes in the Urinary System in Sleep 52
Changes in the Genital System During Sleep 52
Thermoregulation in Sleep 53
III Synopsis of Sleep Disorders 110
10 Sleep Deprivation 110
Epidemiology 110
Sleep Loss Studies in Animal Models 110
Sleep Loss in Humans 111
Effects of Sleep Loss on Attention 111
Sleep Fragmentation 112
Physiologic Effects of Sleep Deprivation 112
Conclusions 112
Suggested Reading 113
References 113.e1
11 The Insomnias 114
Introduction and Definitions 114
Insomnia Evaluation 114
Diagnosis 115
Epidemiology 119
Pathophysiology 119
Consequences and Associations 119
Management 121
Insomnia and Psychiatric Comorbidities 125
Summary 126
Suggested Reading 126
References 126.e1
12 Central Nervous System Hypersomnia 127
Introduction 127
Definitions 127
Prevalence of Hypersomnia 127
The Complaint of Sleepiness 127
Classification of Excessive Daytime Sleepiness 127
“Sleepiness” or “Fatigue”? 129
Manifestations of Sleepiness 130
Physiology of Sleep and Wake 130
Neurotransmitters 130
Pharmacology 130
Making the Diagnosis 131
Clinical History 131
Diagnostic Tests 132
Epworth Sleepiness Scale 132
The Stanford Sleepiness Scale 133
Sleep Logs and Actigraphy 133
Polysomnographic Investigations 134
Multiple Sleep Latency Test (MSLT) 135
General Considerations 135
Interpretation of MSLT 135
SOREMP on PSG 135
Maintenance of Wakefulness Test 135
Continuous 24-Hour Sleep Recording 135
Laboratory Tests 136
Routine Blood Tests. 136
Human Leukocyte Antigen (HLA) Typing 136
Cerebrospinal Fluid Hypocretin-1 136
Imaging Studies–Magnetic Resonance Imaging of the Brain, and Other Diagnostic Tests 137
Psychiatric Evaluation and Psychologic Testing 138
Specific Disorders 138
Narcolepsy 138
Epidemiology 138
Classification 138
Clinical Presentation 138
Cataplexy 138
Other Symptoms Associated with Narcolepsy 139
Diagnosis 140
Pathophysiology 141
Evolution and Prognosis 141
Kleine-Levin Syndrome 141
Epidemiology 141
Clinical Presentation 143
Diagnostic Tests 144
Differential Diagnosis 144
Treatment 144
Evolution and Prognosis 144
Idiopathic Hypersomnia 144
Definition 144
Epidemiology 145
Clinical Presentation 145
Diagnosis 145
Evolution and Prognosis 145
Pathophysiology 145
Treatment Strategies for Central Nervous System Hypersomnia 145
Behavioral Treatments 145
Wake-Promoting Agents 147
Modafinil, Armodafinil 147
Amphetamine-Like Stimulants 147
Pharmacologic Management 147
Anticataplectic Agents: Antidepressants 147
Sodium Oxybate 148
Mechanism of Action 148
Clinical Benefit 148
Dosing 148
Adverse Effects 148
Treatment of Ancillary and Associated Conditions 148
Narcolepsy-Cataplexy: Novel Approaches 149
Investigational Agents 149
Conclusion and Perspectives 149
Suggested Reading 149
References 149.e1
13 Sleep-Related Breathing Disorders 150
Introduction 150
Obstructive Sleep Apnea 150
Epidemiology 151
Factors That Increase Prevalence 151
Comorbid Associations 151
Effect of Body Mass Index, Gender, and Age 152
Definitions 152
Obstructive Apnea in Adults 152
Scoring of Hypopnea Is Less Straightforward 152
Distinguishing Obstructive Versus Central Hypopnea 152
Pediatric Criteria 152
Pathophysiology 152
Critical Closing Pressure 152
Loop Gain 152
Upper Airway Recruitment Threshold 152
Arousal Threshold 152
Interaction of Variables 152
Obesity Is a Major Risk Factor 152
Influence of Sex Hormones 153
Predisposing Factors in Childhood 153
Physiologic Consequences 153
Cardiac Effects 153
Systemic Consequences 153
Hormonal Responses 154
Atherosclerotic Cardiovascular Disease 154
Multiple Other Consequences 154
Consequences of Sleep Fragmentation 154
Clinical Evaluation 154
The Body Mass Index Varies Significantly 154
Variable Presentations 154
Diabetes and Metabolic Syndrome 154
Hypotonia Predisposes to Obstructive Sleep Apnea 155
Perioperative Complications 155
Reports from Family Members or Bed Partner 155
Physical Examination Clues 155
Diagnosis 155
Pediatric Sleep Laboratories 155
Diagnostic Criteria 155
Obstructive Sleep Apnea Diagnosis in Children Is Less Precise 156
Alternative Diagnostic Approaches 156
Unattended Portable Monitoring 156
Central Apnea 157
Pathophysiology 157
History and Examination 158
Diagnosis 158
Cheyne-Stokes Respiration 158
Pathophysiology 158
Associated Conditions 158
High-Altitude Periodic Breathing 159
Idiopathic Central Sleep Apnea 159
Central Apnea Associated with Baseline Hypercapnia 159
Mixed Central and Obstructive Apnea 159
Snoring 160
Risk Factors 160
History 160
Examination 160
Complications 160
IV Testing Knowledge in Sleep Medicine: Practice Exams 425
28 Mechanism and Disorders of Circadian Physiology 425
Questions 425
Answers 427
Suggested Reading 435
References 435.e1
29 Tools in Clinical Sleep Medicine 436
Questions 436
Answers 443
Suggested Reading 452
References 452.e1
30 Practice Examination—Pediatric Sleep Disorders 453
Questions 453
Answers 460
Suggested Reading 465
References 465.e1
31 Cardiology in Sleep Medicine 466
Questions 466
Answers 475
Suggested Reading 479
References 479.e1
32 Pulmonary Sleep Clinical Case Studies 480
Questions 480
Answers 486
Suggested Reading 498
References 498.e1
33 Psychiatry Clinical Case Studies 499
Questions 499
Answers 504
Suggested Reading 508
References 508.e1
34 Insomnia Clinical Pearls 509
Questions 509
Answers 516
Suggested Reading 520
References 520.e1
35 Neurology in Sleep Medicine 521
Questions 521
Answers 529
Suggested Reading 539
References 539.e1
36 Hypersomnia Case Studies 540
Questions 540
Questions 1–14 Refer to Patient A 540
Questions 18–20 Refer to Patient B 542
During the First Trial of the MWT, the Following Results Are Obtained 542
Questions 21–22 Refer to Patient C 543
Questions 23–25 Refer to Patient D 543
Questions 26–29 Refer to Patient E 544
Questions 30–32 Refer to Patient F 544
Answers 545
Suggested Reading 556
References 556.e1
37 Clinical Cases 557
Questions 557
Answers 561
Suggested Reading 572
References 572.e1
38 Rapid Eye Movement and Nonrapid Eye Movement Parasomnias 573
Questions 573
Answers 579
Suggested Reading 586
References 586.e1
39 Seizures and Sleep 587
Questions 587
Answers 591
Case 1 591
Case 2 595
Case 3 595
Case 4 596
Case 5 597
Case 6 597
References 598.e1
40 Sleep-Related Movement Disorders 599
Questions 599
Answers 601
Acknowledgments 620
Suggested Reading 620
References 621.e1
41 Sleep in Medical Disorders and Special Populations 622
Questions 622
Endocrine 622
HIV 622
GI 622
Pregnancy 623
Fibromyalgia 624
Chronic Fatigue Syndrome 625
Renal 625
Cancer 625
Answers 625
Suggested Reading 632
References 632.e1
42 Sleep Pharmacology 633
Questions 633
Answers 636
Suggested Reading 641
References 641.e1
43 Polysomnography Pearls 642
Questions 642
Answers 650
Suggested Reading 657
References 657.e1
44 Sleep Stage Scoring 658
Channel Key 658
Questions 658
Waveform Recognition 658
Stage Scoring 658
Events 664
Multi-Epoch Scoring (Scoring in Context) 669
Answers 675
Waveform Recognition 675
Stage Scoring 681
Events 686
Multi-Epoch Scoring (Scoring in Context) 690
Suggested Reading 694
References 694.e1
45 Artifacts 695
Questions 695
Answers 712
Channel Key 745
Suggested Reading 746
References 746.e1
46 Use of Statistics in Sleep Medicine 747
Questions 747
Answers 749
Commonly Used Statistical Terms 750
References 750.e1
47 Knowing Your Sleep Practice Parameters 751
Aasm Practice Parameter Review Questions 751
Answers 754
Suggested Reading 758
References 758.e1
48 Quality Measures in Sleep Medicine 759
Questions 759
Answers 762
Suggested Reading 772
References 772.e1
49 Normal Sleep 773
Questions 773
Answers 778
Suggested Reading 788
References 788.e1
50 Mechanisms of Sleep Neuroscience 789
Questions 789
Answers 792
Acknowledgment 808
Suggested Reading 808
References 808.e1
Appendices e25
Appendix I Statistics in Medicine e25
Introduction e25
Types of Data e25
Descriptive Statistics e25
Frequency Distribution Curves e25
Inferential Statistics e27
Hypothesis Testing e28
Choice of Statistical Test e28
Multiple Significance Testing e28
Contingency Tables e29
Repeated Measurements e29
Correlation and Regression e30
Method Comparison Studies e31
Multiple Regression Analysis e31
Meta-Analysis and Systematic Reviews e31
Suggested Reading e31
Appendix II Cardiac Arrhythmias e32
Anatomy and Pathways e32
Cardiac Cycle e32
Normal Electrocardiogram Parameters e32
Electrocardiogram Abnormalities e32
Arrhythmia Analysis e32
Step 1. Examine the P Wave e32
Step 2. Examine the QRS Complex e34
Step 3. Examine the P and QRS Relationship e34
Step 4. Measure the Intervals e34
Step 5. Regular or Irregular Rhythm e34
Step 6. Determine the Rate e34
Common Atrial Arrhythmias e34
Junctional Arrhythmias e38
Blocks e39
Ventricular Arrhythmias e42
Interventions e46
Recording and Monitoring Techniques e47
Suggested Reading e47
Appendix III Statistics for Clinical Trials and Audit e48
Study Designs e48
Power Analysis e49
Presentation of Results e50
Diagnostic Tests e50
Statistical Applications in Quality Assurance e50
References e52
Suggested Reading e52
Appendix IV Horne-Östberg Morningness-Eveningness Questionnaire e53
Suggested Reading e54
Index 809
A 809
B 811
C 811
D 814
E 814
F 816
G 816
H 817
I 818
J 819
K 819
L 819
M 820
N 821
O 822
P 823
Q 826
R 826
S 827
T 830
U 831
V 831
W 831
Y 831
Z 831