Additional Information
Book Details
Abstract
The new edition of Physiology in Childbearing with Anatomy and Related Biosciences continues to offer readers with a sound introduction to human biology as it relates to pregnancy and childbirth. The new edition retains the online question bank with downloadable image collection and is suitable for midwives – whether qualified or in training – throughout the world.
- Straightforward writing style helps demystify a challenging subject area
- Applies theory to practice to show how a knowledge of the biological sciences can enhance the care given to mothers and babies
- Designed to facilitate early recognition of pathology to help prevent morbidity and mortality
- Ideal introduction to basic biochemistry, cellular biology and genetics for those who have no prior knowledge of the subject areas
- Chapters on embryology help explain the occurrence of neonatal pathology
- A ‘body systems approach’ – including embryological development – enables an understanding of the physiological and pathophysiological changes that occur during pregnancy
- Clear diagrams allow an understanding of the complex three-dimensional concepts seen in biology
- Helpful pedagogy such as ‘Main Points’ boxes at the end of each chapter act as useful aide-memoires
- Enhances the safety of mothers and babies, both in the developed world and those countries where the provision of adequate care remains limited
- Revised contributor team provides an international perspective
- Updated design presents shorter sections of information with concise summaries of ‘key points’ and easy to interpret figures and tables
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front Cover | cover | ||
Inside Front Cover | ifc1 | ||
Half title page | i | ||
Dedication | ii | ||
Physiology in Childbearing | iii | ||
Copyright Page | iv | ||
Table Of Contents | v | ||
Contributors | vii | ||
Preface | ix | ||
Acknowledgements | xi | ||
Illustration Acknowledgements | xiii | ||
List of Abbreviations | xv | ||
2A Pregnancy—The Fetus | 77 | ||
Section Contents | 77 | ||
9 General embryology | 79 | ||
Chapter Contents | 79 | ||
Introduction | 79 | ||
Embryology | 79 | ||
Gametogenesis | 79 | ||
Oogenesis | 79 | ||
Spermatogenesis | 79 | ||
Gamete size | 80 | ||
Fertilization | 81 | ||
Results of fertilization | 81 | ||
The embryo | 81 | ||
Terminology | 81 | ||
Programming the embryo | 81 | ||
Pattern formation | 82 | ||
Early cell division–cleavage | 82 | ||
Differentiation | 83 | ||
Morphogenesis | 83 | ||
Regulatory genes | 83 | ||
The homeobox | 84 | ||
Morphogens | 84 | ||
Induction | 84 | ||
Cell communication | 84 | ||
Programmed cell death | 85 | ||
Development of the embryo | 85 | ||
The blastocyst | 85 | ||
Implantation | 85 | ||
The effects of enzymatic erosion | 85 | ||
Development of the germ layers | 85 | ||
The bilaminar embryonic disc | 85 | ||
The trilaminar embryo | 85 | ||
The primitive streak | 86 | ||
Gastrulation | 86 | ||
Development of body cavities | 87 | ||
Formation of the notochord | 87 | ||
Organogenesis | 88 | ||
Differentiation of the germ layers | 88 | ||
Ectoderm | 88 | ||
Neurulation | 88 | ||
Mesoderm | 88 | ||
Endoderm | 88 | ||
Folding of the embryo | 88 | ||
Longitudinal folding | 88 | ||
Transverse folding | 88 | ||
References | 92 | ||
Annotated recommended reading | 92 | ||
10 Embryological systems 1—trunk, head and limbs | 93 | ||
Chapter Contents | 93 | ||
Introduction | 93 | ||
The trunk | 93 | ||
Skeletal features | 93 | ||
The vertebral column | 93 | ||
Precartilaginous phase | 93 | ||
Cartilaginous phase | 93 | ||
Bony phase | 93 | ||
Ribs and sternum | 93 | ||
Soft tissues | 94 | ||
Myotomes | 94 | ||
Dermatomes | 94 | ||
The skin and mammary glands | 94 | ||
The skull | 94 | ||
The viscerocranium | 94 | ||
The teeth | 94 | ||
The brain | 95 | ||
The changing shape of the brain | 95 | ||
The forebrain | 95 | ||
Other brain structures | 95 | ||
Blood supply to the brain | 95 | ||
The spinal cord | 95 | ||
Zones of the spinal cord | 95 | ||
Cells from the neural crest | 95 | ||
Structures of the head and neck | 96 | ||
Pharyngeal apparatus | 96 | ||
Pharyngeal arches | 96 | ||
The structure of the pharyngeal arches | 96 | ||
Pharyngeal pouches and grooves | 96 | ||
Derivatives of the pharyngeal arches | 96 | ||
First pharyngeal arch | 96 | ||
Second pharyngeal arch | 96 | ||
Third pharyngeal arch | 96 | ||
Fourth and sixth pharyngeal arches | 96 | ||
Derivatives of the pharyngeal pouches | 96 | ||
Derivatives of the pharyngeal grooves | 98 | ||
The face | 98 | ||
The ears | 98 | ||
The outer and middle ear | 98 | ||
The inner ear | 98 | ||
The eyes | 98 | ||
The optic cup | 99 | ||
The eyelids and lacrimal apparatus | 99 | ||
The limbs | 99 | ||
Development of the limbs | 99 | ||
Formation of the hands and feet | 99 | ||
Development and rotation of the limbs | 100 | ||
Muscles and nerves of the limbs | 100 | ||
Blood supply to the limbs | 100 | ||
References | 101 | ||
Annotated recommended reading | 101 | ||
11 Embryological systems 2—internal organs | 103 | ||
Chapter Contents | 103 | ||
Introduction | 103 | ||
The cardiovascular system | 103 | ||
Vasculogenesis and angiogenesis | 103 | ||
The primordial cardiovascular system | 103 | ||
Development of the heart | 104 | ||
Blood flow through the early heart | 104 | ||
Partitioning of the heart | 105 | ||
The lower respiratory tract | 105 | ||
Development of the laryngotracheal tube | 105 | ||
Development of the lungs | 105 | ||
The diaphragm | 105 | ||
The alimentary tract | 105 | ||
The foregut | 106 | ||
The oesophagus | 106 | ||
The stomach | 106 | ||
The duodenum | 106 | ||
The liver, gall bladder, pancreas and spleen | 106 | ||
Development of the veins of the liver | 106 | ||
The midgut | 106 | ||
The hindgut: the rectum and anal canal | 107 | ||
The urinary and genital tracts | 107 | ||
The kidneys and ureters | 107 | ||
Development of the collecting system | 107 | ||
The bladder and urethra | 107 | ||
The suprarenal glands | 108 | ||
The reproductive system | 108 | ||
Testes and the male genital tract | 108 | ||
Ovaries and the female genital tract | 108 | ||
The vagina | 109 | ||
The external genitalia | 109 | ||
Estimation of embryonic age | 109 | ||
References | 109 | ||
Annotated recommended reading | 110 | ||
12 The placenta, membranes and amniotic fluid | 111 | ||
Chapter Contents | 111 | ||
Introduction | 111 | ||
Implantation | 111 | ||
Development of the chorionic villi | 111 | ||
Formation of the cytotrophoblastic shell | 112 | ||
Later placental development | 112 | ||
The mature placenta | 112 | ||
Appearance | 112 | ||
The membranes | 115 | ||
The umbilical cord | 115 | ||
The umbilical vesicle (yolk sac) and allantois | 115 | ||
The placental circulation | 116 | ||
Anatomical variations of the placenta | 116 | ||
Functions of the placenta | 116 | ||
Endocrine function | 118 | ||
The protein hormones | 119 | ||
The steroid hormones: oestrogens | 119 | ||
Oestrogen levels in normal pregnancy | 119 | ||
The steroid hormones: progesterone | 119 | ||
The function of progesterone in pregnancy | 119 | ||
Progesterone levels in normal and abnormal pregnancy | 120 | ||
Transfer of substances | 120 | ||
Mechanisms of transfer | 120 | ||
Respiration | 120 | ||
Fetal oxygen supply | 120 | ||
Carbon dioxide | 120 | ||
Nutrition | 120 | ||
Carbohydrate transfer | 120 | ||
Amino acid transfer | 120 | ||
Lipid transfer | 121 | ||
Vitamin transfer | 121 | ||
Trace element transfer | 121 | ||
Water and electrolyte transfer | 121 | ||
Excretion | 121 | ||
Protection | 121 | ||
Immunological role | 121 | ||
Amniotic fluid | 121 | ||
Production of amniotic fluid | 121 | ||
Sources of amniotic fluid | 121 | ||
Circulation of amniotic fluid | 121 | ||
Content of amniotic fluid | 121 | ||
Regulation of amniotic fluid quantity | 121 | ||
Functions of amniotic fluid | 122 | ||
Clinical implications: abnormalities of quantity | 122 | ||
Polyhydramnios | 122 | ||
Oligohydramnios | 122 | ||
Diagnostic uses of amniotic fluid | 123 | ||
Biophysical profile | 123 | ||
Amniocentesis | 123 | ||
References | 124 | ||
Annotated recommended reading | 124 | ||
13 Fetal growth and development | 125 | ||
Chapter Contents | 125 | ||
Introduction | 125 | ||
The fetal period | 125 | ||
Fetal growth | 125 | ||
Control of cell growth and proliferation | 125 | ||
Key events in the fetal stage of development | 125 | ||
Fetal size | 125 | ||
Estimation of fetal age and assessment of fetal growth | 127 | ||
Growth curves | 127 | ||
Maternal weight and fetal growth | 127 | ||
Ultrasound | 130 | ||
Linear measurements | 130 | ||
Non-linear measurements | 130 | ||
Ratios | 130 | ||
Doppler wave form analysis | 130 | ||
Multiple pregnancies | 130 | ||
Types of twin pregnancy | 130 | ||
Dizygotic | 130 | ||
Monozygotic | 130 | ||
The incidence of multiple pregnancies | 131 | ||
Triplets and higher-order pregnancies | 131 | ||
Diagnosis of twin pregnancy | 132 | ||
Abdominal examination | 132 | ||
Inspection | 132 | ||
Palpation | 132 | ||
Auscultation | 132 | ||
Ultrasound | 132 | ||
Complications of pregnancy | 132 | ||
Fetal problems | 132 | ||
Abortion (Miscarriage) | 132 | ||
Single fetus demise | 132 | ||
Congenital malformations | 132 | ||
Monoamniotic twins | 132 | ||
Conjoined twins | 132 | ||
Acardiac twinning | 133 | ||
Twin–twin transfusion syndrome | 133 | ||
Polyhydramnios | 134 | ||
Intrauterine growth retardation | 134 | ||
Maternal problems | 134 | ||
Exacerbation of minor disorders | 134 | ||
Anaemia | 134 | ||
Pregnancy-induced hypertension | 134 | ||
Antepartum haemorrhage | 134 | ||
Complications of labour | 134 | ||
Fetal malpresentations | 134 | ||
Locked twins | 134 | ||
Umbilical cord problems | 134 | ||
Preterm onset of labour | 135 | ||
Mode of delivery | 135 | ||
Postpartum haemorrhage | 135 | ||
Undiagnosed twins | 135 | ||
Postnatal care of mother and babies | 135 | ||
Care of the babies | 135 | ||
Care of the mother | 135 | ||
References | 135 | ||
Annotated recommended reading | 136 | ||
14 Common fetal problems | 137 | ||
Chapter Contents | 137 | ||
Introduction | 137 | ||
Intrauterine growth retardation | 137 | ||
Complications of IUGR | 137 | ||
Factors adversely affecting fetal growth | 137 | ||
Maternal malnutrition | 137 | ||
Smoking | 138 | ||
Alcohol consumption | 138 | ||
Placental insufficiency | 138 | ||
Multiple pregnancy | 138 | ||
Genetic factors and chromosomal aberrations | 138 | ||
Diagnosis and management of IUGR | 138 | ||
Delivery of the baby | 138 | ||
Rhesus isoimmunization and ABO incompatibility | 138 | ||
Rhesus isoimmunization (RhD incompatibility) | 138 | ||
Prevention of maternal isoimmunization | 139 | ||
Antenatal management: anti-D prophylaxis | 139 | ||
Care at delivery | 139 | ||
Management if rhesus antibodies are present during pregnancy | 139 | ||
Rhesus haemolytic disease | 139 | ||
ABO incompatibility | 139 | ||
Maternal infection in pregnancy | 140 | ||
Suppression of cell-mediated immunity | 140 | ||
Sexually transmitted diseases | 140 | ||
Bacterial infections | 140 | ||
Gonorrhoea | 140 | ||
Syphilis | 140 | ||
Chlamydia | 140 | ||
Group B streptococcus | 140 | ||
Viral infections | 140 | ||
Human immunodeficiency virus | 140 | ||
TORCH organisms and pregnancy risk | 141 | ||
Rubella | 141 | ||
Varicella | 141 | ||
Cytomegalovirus | 141 | ||
Toxoplasmosis | 141 | ||
Herpes simplex | 141 | ||
Listeriosis | 142 | ||
Hepatitis B (serum hepatitis) | 142 | ||
Hepatitis C | 142 | ||
References | 143 | ||
Annotated recommended reading | 143 | ||
15 Congenital anomalies | 145 | ||
Chapter Contents | 145 | ||
Introduction | 145 | ||
General causes of congenital anomalies | 145 | ||
Genetic causes | 145 | ||
Chromosomal abnormalities | 145 | ||
Down syndrome | 146 | ||
Single gene disorders | 147 | ||
Cystic fibrosis | 147 | ||
Multifactorial inheritance | 148 | ||
Cleft lip and cleft palate | 148 | ||
Neural Tube Defects | 148 | ||
Environmental factors | 149 | ||
Teratogens | 149 | ||
Drugs | 150 | ||
Prenatal screening for congenital anomalies | 150 | ||
Ultrasonography | 150 | ||
Obtaining fetal tissue for genetic testing | 150 | ||
Amniocentesis | 151 | ||
Chorionic villus sampling | 151 | ||
Fetal blood sampling | 151 | ||
Non-invasive prenatal testing | 151 | ||
Conclusion | 151 | ||
References | 151 | ||
Annotated recommended reading | 152 | ||
2B Pregnancy—The Mother | 153 | ||
Section Contents | 153 | ||
16 The haematological system—physiology of the blood | 155 | ||
Chapter Contents | 155 | ||
Blood as a tissue | 155 | ||
Functions of blood | 155 | ||
Constituents of blood | 155 | ||
Plasma | 156 | ||
The cellular components of blood | 156 | ||
Red blood cells | 157 | ||
Haemoglobin | 157 | ||
Formation of erythrocytes | 158 | ||
The life span of red cells | 158 | ||
Iron metabolism | 158 | ||
Absorption | 158 | ||
Serum iron, transferrin and total iron-binding capacity | 159 | ||
Serum ferritin | 159 | ||
Marrow iron | 159 | ||
Folate metabolism | 159 | ||
Blood groups | 159 | ||
The ABO system | 159 | ||
The rhesus (Rh) system | 159 | ||
White cells | 160 | ||
Types of white cells | 160 | ||
The production of granulocytes | 160 | ||
Agranulocytes | 160 | ||
Lymphocytes | 160 | ||
Monocytes | 160 | ||
Platelets | 160 | ||
Haemostasis | 161 | ||
Vascular spasm | 161 | ||
Formation of a platelet plug | 161 | ||
Coagulation | 161 | ||
Clot retraction and fibrinolysis | 162 | ||
Factors limiting clot growth or formation | 162 | ||
Maternal haematological adaptations to pregnancy | 162 | ||
Blood volume and composition | 162 | ||
Plasma volume | 163 | ||
Blood cellular components | 163 | ||
Iron requirements during pregnancy | 163 | ||
Folate metabolism in pregnancy | 163 | ||
Haemostasis in pregnancy | 163 | ||
Intrapartum and immediate postpartum periods | 164 | ||
References | 166 | ||
Annotated recommended reading | 166 | ||
Website | 166 | ||
17 The cardiovascular system | 167 | ||
Chapter Contents | 167 | ||
Introduction | 167 | ||
Circulatory pathways | 167 | ||
Anatomy of the heart | 167 | ||
Description | 167 | ||
Layers | 168 | ||
Chambers and valves | 169 | ||
The atrioventricular valves | 169 | ||
The semilunar valves | 169 | ||
The coronary circulation | 169 | ||
Pulmonary and systemic circulations | 169 | ||
Physiology of the heart | 169 | ||
The electrical conducting system (nodal system) | 170 | ||
The cardiac cycle | 170 | ||
Control of the heart rate | 170 | ||
Intrinsic control | 170 | ||
Extrinsic control | 170 | ||
Nervous control | 170 | ||
Hormonal control | 171 | ||
Stretch | 171 | ||
Stroke volume | 171 | ||
Cardiac output | 172 | ||
Other influences | 172 | ||
The vascular system | 172 | ||
Structure of blood vessels | 172 | ||
The arterial system | 172 | ||
Elastic arteries (conducting arteries) | 172 | ||
Muscular arteries (distributing arteries) | 172 | ||
Arterioles | 172 | ||
Capillaries | 172 | ||
The microcirculation | 173 | ||
The venous system | 174 | ||
The physiology of circulation | 175 | ||
Blood vessel diameter | 175 | ||
Nervous control | 175 | ||
Chemical control | 175 | ||
Endothelial-mediated regulation | 175 | ||
Blood pressure | 175 | ||
Fluid pressure | 175 | ||
Fluid flow | 176 | ||
Venous return | 176 | ||
Arterial blood pressure | 176 | ||
Pulse pressure and mean arterial pressure | 176 | ||
The regulation of blood pressure | 176 | ||
Neural system | 176 | ||
Chemical control | 177 | ||
The renal system | 177 | ||
Blood pressure values | 177 | ||
The formation of tissue fluid | 178 | ||
Hydrostatic pressure | 178 | ||
Osmotic pressure | 178 | ||
Diffusion | 178 | ||
Maternal adaptations to pregnancy | 179 | ||
Haemodynamic changes | 179 | ||
Size and position of the heart | 179 | ||
Control of cardiovascular changes | 180 | ||
References | 181 | ||
Annotated recommended reading | 181 | ||
18 Respiration | 183 | ||
Chapter Contents | 183 | ||
Introduction | 183 | ||
Anatomy of the respiratory system | 183 | ||
The upper airways | 183 | ||
The lower respiratory tract | 184 | ||
The thoracic cage | 185 | ||
Physiology of the respiratory tract | 185 | ||
The epithelial lining | 185 | ||
Reflex mechanisms | 185 | ||
Structure and function of the alveoli | 185 | ||
Surfactant | 186 | ||
Blood supply to the lungs | 186 | ||
Nerve supply to the respiratory muscles | 186 | ||
The physiology of pulmonary ventilation (breathing) | 186 | ||
Mechanical factors | 186 | ||
Inspiration | 187 | ||
Expiration | 187 | ||
Pulmonary ventilation | 187 | ||
Respiratory parameters | 187 | ||
Respiratory volumes | 187 | ||
Respiratory capacities | 187 | ||
Minute volume | 187 | ||
Alveolar ventilation | 188 | ||
Transport of gases around the body | 188 | ||
Gas exchange in tissues | 188 | ||
Transport of oxygen | 188 | ||
Partial pressure gradients and gas diffusion | 188 | ||
The oxygen dissociation curve | 188 | ||
Factors influencing the oxygen–haemoglobin dissociation curve | 188 | ||
Increase in carbon dioxide | 188 | ||
Increase in hydrogen ions | 189 | ||
Increase in 2,3-diphosphoglycerate | 189 | ||
Increase in temperature | 189 | ||
Carbon monoxide | 189 | ||
Transport of carbon dioxide | 189 | ||
Bicarbonate ions | 189 | ||
The chloride shift | 189 | ||
Hydrogen ions, carbon dioxide and the acid–base balance | 189 | ||
Control of ventilation | 190 | ||
Medullary respiratory centres | 190 | ||
The dorsal respiratory group | 190 | ||
The respiratory cycle | 190 | ||
Factors influencing the rate and depth of breathing | 190 | ||
Voluntary control of breathing | 190 | ||
Chemoreceptor effects | 190 | ||
The Hering–Breuer reflex | 190 | ||
Maternal adaptations to pregnancy | 190 | ||
Upper respiratory tract changes | 190 | ||
Anatomical changes | 190 | ||
Biochemical changes | 191 | ||
Carbon dioxide | 191 | ||
Oxygen | 192 | ||
Postpartum changes | 192 | ||
References | 194 | ||
Annotated recommended reading | 194 | ||
Website | 194 | ||
19 The renal tract | 195 | ||
Chapter Contents | 195 | ||
Introduction | 195 | ||
Kidney functions | 195 | ||
Anatomy of the kidney | 195 | ||
Structure | 195 | ||
Microscopic structure of the kidney | 196 | ||
The role of blood pressure | 197 | ||
Renal function | 197 | ||
The production of urine | 197 | ||
Glomerular filtration | 197 | ||
Tubular reabsorption and secretion | 198 | ||
Hormones influencing selective reabsorption | 198 | ||
Regulation of urine concentration and volume | 199 | ||
Formation of concentrated urine | 202 | ||
The lower urinary tract | 202 | ||
The ureters | 202 | ||
2C Pregnancy–The Problems | 315 | ||
Section Contents | 315 | ||
30 Minor disorders of pregnancy | 317 | ||
Chapter Contents | 317 | ||
Introduction | 317 | ||
Maintenance of pregnancy | 317 | ||
Minor disorders of pregnancy | 317 | ||
The digestive system | 317 | ||
Nausea and vomiting | 317 | ||
Heartburn | 318 | ||
Ptyalism | 318 | ||
Pica | 318 | ||
Constipation | 318 | ||
Skin | 319 | ||
The cardiovascular system | 319 | ||
Fainting | 319 | ||
Varicosities | 319 | ||
The musculoskeletal system | 319 | ||
Backache | 319 | ||
The nervous system | 319 | ||
Carpal tunnel syndrome | 319 | ||
Fatigue and emotional changes | 320 | ||
The genitourinary system | 320 | ||
Frequency of micturition | 320 | ||
Leucorrhoea | 320 | ||
Conclusion | 320 | ||
References | 320 | ||
Annotated recommended reading | 321 | ||
31 Bleeding in pregnancy | 323 | ||
Chapter Contents | 323 | ||
Bleeding in early pregnancy | 323 | ||
Implantation bleeding | 323 | ||
Miscarriage (abortion) | 323 | ||
Classification of miscarriage (abortion) | 323 | ||
Threatened miscarriage | 323 | ||
Inevitable miscarriage | 324 | ||
Missed miscarriage | 324 | ||
Recurrent miscarriage | 324 | ||
Induced abortion (therapeutic) | 324 | ||
Gestational trophoblastic tumours | 325 | ||
Hydatidiform mole | 325 | ||
Aetiology | 325 | ||
Signs and symptoms | 325 | ||
Management | 325 | ||
Choriocarcinoma and placental site tumours | 325 | ||
Treatment | 326 | ||
Ectopic pregnancy | 326 | ||
Tubal pregnancy | 326 | ||
Risk factors | 326 | ||
Pathophysiology | 326 | ||
Diagnosis | 326 | ||
Management | 327 | ||
Prognosis | 327 | ||
Bleeding from associated conditions | 327 | ||
Cervical polyps | 327 | ||
Cervical erosion | 327 | ||
Carcinoma of the cervix | 327 | ||
Cervical intraepithelial neoplasia | 327 | ||
Invasive carcinoma of the cervix | 328 | ||
Vaginitis | 328 | ||
Antepartum haemorrhage | 328 | ||
Placenta praevia | 328 | ||
Classification of placenta praevia | 328 | ||
Aetiology of placenta praevia | 329 | ||
Blood loss | 329 | ||
Management | 329 | ||
General examination | 329 | ||
Abdominal examination | 329 | ||
Conservative management | 329 | ||
Delivery | 329 | ||
Active management | 329 | ||
Third stage | 329 | ||
Placental abruption (abruptio placentae) | 329 | ||
Risk factors | 330 | ||
Blood loss | 330 | ||
Management of placental abruption | 331 | ||
Blood coagulation disorders | 331 | ||
Other complications | 331 | ||
Vasa praevia | 332 | ||
References | 332 | ||
Annotated recommended reading | 333 | ||
32 Cardiac and hypertensive disorders | 335 | ||
Chapter Contents | 335 | ||
Introduction | 335 | ||
Cardiac disorders in pregnancy | 335 | ||
Risk factors | 335 | ||
Main types of cardiac disorder | 336 | ||
Congenital heart disease | 336 | ||
Categorization of congenital heart disease | 336 | ||
Eisenmenger’s syndrome | 336 | ||
Marfan’s syndrome | 336 | ||
Assessment of mothers with heart disease | 336 | ||
New York Heart Association classification | 336 | ||
Management of women with heart disease | 336 | ||
Specific aspects of care | 336 | ||
Intrapartum care | 336 | ||
Second stage | 337 | ||
Third stage | 337 | ||
Postnatal care | 337 | ||
Hypertension in pregnancy | 337 | ||
Terminology | 337 | ||
Classification | 337 | ||
Incidence | 337 | ||
Pathogenesis | 337 | ||
Outcomes | 338 | ||
Eclampsia | 338 | ||
Prediction | 338 | ||
HELLP syndrome | 338 | ||
Management of hypertensive conditions | 338 | ||
Rest and observation | 338 | ||
Fetal observations | 339 | ||
Delivery | 339 | ||
Control of blood pressure | 339 | ||
Anticonvulsive therapy | 339 | ||
Prevention | 339 | ||
References | 340 | ||
Annotated recommended reading | 341 | ||
33 Anaemia and clotting disorders | 343 | ||
Chapter Contents | 343 | ||
Anaemia | 343 | ||
Recognition and incidence of anaemia | 343 | ||
Iron-deficiency anaemia | 343 | ||
Pathology | 343 | ||
Folic acid–deficiency anaemia and the role of vitamins | 343 | ||
Management | 345 | ||
Haemoglobinopathies | 345 | ||
The globin chains | 345 | ||
Sickle cell disease | 347 | ||
Pathophysiology | 347 | ||
Thalassaemia | 347 | ||
Glucose-6-phosphate dehydrogenase deficiency | 348 | ||
Thromboembolism and pregnancy | 348 | ||
Superficial thrombophlebitis | 348 | ||
Deep vein thrombosis | 348 | ||
Factors associated with pregnancy predisposing to thromboembolism | 348 | ||
Pathogenesis | 348 | ||
3A Labour–Normal | 371 | ||
Section Contents | 371 | ||
36 The onset of labour | 373 | ||
Chapter Contents | 373 | ||
Introduction | 373 | ||
The onset of labour | 373 | ||
Fetal factors associated with the onset of labour | 373 | ||
The role of the fetal hypothalamus– pituitary–adrenal axis | 373 | ||
The fetal posterior pituitary gland | 375 | ||
The role of the placenta (Fig. 36.3) | 375 | ||
Progesterone | 375 | ||
Oestrogens | 375 | ||
Fetal membranes | 375 | ||
Prostaglandins | 375 | ||
Maternal influences | 376 | ||
The endocrine system | 376 | ||
Neurohormonal control | 376 | ||
Control of cervical changes in labour | 376 | ||
Definitions of labour | 377 | ||
Maternal physiological adaptation in labour | 378 | ||
Cardiovascular system | 378 | ||
Haematological system | 378 | ||
Respiratory system | 378 | ||
Maternal acidosis | 378 | ||
Maternal alkalosis | 378 | ||
Renal system | 379 | ||
Gastrointestinal system | 379 | ||
Gastric emptying | 379 | ||
Metabolism | 379 | ||
Clinical implications | 379 | ||
Recognition of the onset of labour | 379 | ||
Initial examination of the woman | 379 | ||
The history | 379 | ||
General examination | 379 | ||
Assessing progress in labour | 380 | ||
References | 380 | ||
Annotated recommended reading | 380 | ||
37 The first stage of labour | 381 | ||
Chapter Contents | 381 | ||
Physiology of the first stage of labour | 381 | ||
Uterine activity in labour | 381 | ||
Mechanical factors | 381 | ||
Phases of the first stage of labour | 383 | ||
Individualized care | 383 | ||
Assessing progress in the first stage of labour | 384 | ||
Abdominal examination in labour | 384 | ||
Vaginal examination in labour | 384 | ||
Maternal position in the first stage of labour | 388 | ||
Immersion in water | 390 | ||
Nutrition and hydration in labour | 390 | ||
Nutrition | 390 | ||
Hydration | 390 | ||
Monitoring the fetal condition | 391 | ||
The fetus in the first stage of labour | 391 | ||
Heart rate | 392 | ||
Intermittent monitoring | 392 | ||
Continuous fetal heart recording | 392 | ||
Telemetry | 393 | ||
Findings | 393 | ||
Baseline fetal heart rate | 393 | ||
Baseline variability | 393 | ||
Response of the fetal heart to uterine contractions | 394 | ||
Fetal blood sampling | 395 | ||
Amniotic fluid | 396 | ||
References | 397 | ||
Annotated recommended reading | 397 | ||
38 Pain relief in labour | 399 | ||
Chapter Contents | 399 | ||
Introduction | 399 | ||
Pain perception | 399 | ||
Pain reception | 399 | ||
Classification of pain | 399 | ||
Pain pathways | 400 | ||
The anatomy of the dorsal horn | 400 | ||
Ascending pathways | 400 | ||
Pain modulation | 400 | ||
Control systems descending from the brain | 400 | ||
The gate control theory of pain | 400 | ||
Visceral sensory neurons | 401 | ||
Pain pathways in labour | 401 | ||
The effect of pain | 402 | ||
Management of pain | 403 | ||
Working with pain model | 403 | ||
Non-pharmacological support | 403 | ||
Transcutaneous electrical nerve stimulation | 404 | ||
Systemic analgesia | 405 | ||
Inhalational analgesia | 405 | ||
Stages of anaesthesia | 406 | ||
Obstetric use of inhalational anaesthetics | 406 | ||
Epidural analgesia | 406 | ||
Anatomy of the epidural space | 406 | ||
Indications for epidural analgesia | 407 | ||
Contraindications | 407 | ||
Other drugs | 409 | ||
Spinal anaesthesia | 409 | ||
Pudendal block | 409 | ||
Perineal infiltration | 409 | ||
References | 410 | ||
Annotated recommended reading | 410 | ||
Website | 410 | ||
39 The second stage of labour | 411 | ||
Chapter Contents | 411 | ||
Introduction | 411 | ||
Physiology of the second stage of labour | 411 | ||
Contractions | 411 | ||
The secondary powers | 411 | ||
Descent of the fetus | 411 | ||
Onset of the second stage | 411 | ||
Duration of the second stage | 411 | ||
Mechanisms of labour | 412 | ||
The mechanism of a normal labour | 413 | ||
The movements | 413 | ||
Physiological changes | 413 | ||
The length of the second stage of labour | 415 | ||
Management | 415 | ||
Position of the woman | 415 | ||
Squatting | 415 | ||
Hands and knees/all-fours positions | 415 | ||
Birthing chairs | 416 | ||
Review of upright positions | 416 | ||
Maternal effort in the second stage of labour | 416 | ||
Effect on pelvic soft tissues | 416 | ||
Perineal lacerations | 416 | ||
The episiotomy | 416 | ||
Recommendations for performing an episiotomy | 417 | ||
The incision | 417 | ||
Suturing the perineum | 418 | ||
Infiltration of the perineum | 418 | ||
Obstetric anal sphincter injuries | 418 | ||
The fetus in the second stage of labour | 418 | ||
References | 420 | ||
Annotated recommended reading | 420 | ||
40 The third stage of labour | 421 | ||
Chapter Contents | 421 | ||
Introduction | 421 | ||
Physiology of the third stage of labour | 421 | ||
Separation of the placenta | 421 | ||
Control of bleeding | 421 | ||
Management of the third stage of labour | 422 | ||
The development and use of oxytocic drugs to manage the third stage of labour | 423 | ||
Active versus physiological management | 423 | ||
Syntometrine versus oxytocin | 424 | ||
Examination of the placenta | 424 | ||
References | 425 | ||
Annotated recommended reading | 426 | ||
3B Labour—Problems | 427 | ||
Section Contents | 427 | ||
41 Abnormalities of uterine action and onset of labour | 429 | ||
Chapter Contents | 429 | ||
Introduction | 429 | ||
Abnormalities of uterine action | 429 | ||
Prolonged labour | 429 | ||
Timing of the onset of labour | 429 | ||
Latent or active phase? | 430 | ||
Inefficient uterine action | 430 | ||
Hypotonic uterine action | 430 | ||
Incoordinate uterine action | 430 | ||
Active management of labour | 430 | ||
Augmentation of labour | 431 | ||
Amniotomy | 431 | ||
Oxytocic infusion | 431 | ||
Prolonged second stage of labour | 431 | ||
Management | 431 | ||
Over-efficient uterine action | 431 | ||
Precipitate labour | 431 | ||
Dangers of precipitate labour | 431 | ||
Tonic contraction of the uterus | 433 | ||
Cervical dystocia | 433 | ||
Problems: timing of the onset of labour | 433 | ||
Preterm onset of labour | 433 | ||
Aetiology | 433 | ||
Fetal fibronectin | 433 | ||
Preterm rupture of the membranes | 433 | ||
The use of drugs in preterm onset of labour and preterm rupture of the membranes | 434 | ||
Corticosteroids | 434 | ||
Antibiotics | 434 | ||
Tocolytic drugs | 434 | ||
Labour and delivery | 435 | ||
Prolonged pregnancy | 435 | ||
Risk factors | 435 | ||
Management of post-term pregnancy | 435 | ||
Induction of labour | 436 | ||
Methods | 436 | ||
Cervical ripening | 436 | ||
Prostaglandins | 436 | ||
Mechanical methods for induction of labour | 437 | ||
Sweeping the membranes | 437 | ||
Amniotomy with or without oxytocin | 437 | ||
References | 438 | ||
Annotated recommended reading | 439 | ||
42 Breech presentation | 441 | ||
Chapter Contents | 441 | ||
Introduction | 441 | ||
Breech presentation | 441 | ||
Types of breech presentation | 441 | ||
Aetiology | 441 | ||
Diagnosis of breech presentation | 441 | ||
On discussion | 441 | ||
On abdominal examination | 441 | ||
On vaginal examination | 443 | ||
Ultrasound scan | 443 | ||
Associated risk factors | 443 | ||
Congenital abnormality | 443 | ||
Risks at delivery | 443 | ||
Management of pregnancy | 443 | ||
Cephalic version | 444 | ||
Promotion of spontaneous cephalic version | 444 | ||
Moxibustion | 444 | ||
External cephalic version | 444 | ||
The procedure for ECV | 444 | ||
The role of planned caesarean section at term | 445 | ||
Vaginal delivery | 446 | ||
Management | 446 | ||
The mechanism of a breech delivery | 446 | ||
The movements | 446 | ||
Compaction and flexion | 446 | ||
Internal rotation of the buttocks | 446 | ||
Lateral flexion of the trunk | 446 | ||
Restitution | 446 | ||
Internal rotation of the shoulders | 446 | ||
Birth of the shoulders | 447 | ||
Internal rotation and delivery of the head | 447 | ||
The first stage of labour | 447 | ||
The second stage of labour | 447 | ||
Vaginal breech birth | 447 | ||
Assisted breech delivery | 447 | ||
The buttocks | 447 | ||
Extended legs | 448 | ||
The body | 448 | ||
The arms | 448 | ||
Extended arms | 448 | ||
The head | 448 | ||
Mauriceau–Smellie–Veit (modified) manoeuvre | 449 | ||
Burns–Marshall manoeuvre | 449 | ||
Entrapment of the fetal head | 450 | ||
Undiagnosed cephalopelvic disproportion | 450 | ||
Posterior rotation of the occiput | 450 | ||
References | 450 | ||
Annotated recommended reading | 451 | ||
43 Malposition and cephalic malpresentations | 453 | ||
Chapter Contents | 453 | ||
Introduction | 453 | ||
Occipitoposterior position of the vertex | 453 | ||
Causes | 453 | ||
Attitude | 453 | ||
Diagnosis in pregnancy | 453 | ||
Diagnosis in labour | 453 | ||
The first stage of labour | 453 | ||
The role of maternal position | 454 | ||
The second stage of labour | 456 | ||
Deep transverse arrest of the head | 456 | ||
Diagnosis and management | 456 | ||
Short internal rotation of sinciput and ‘face to pubes’ delivery | 458 | ||
Diagnosis | 458 | ||
Management of the spontaneous delivery | 458 | ||
Face presentation | 458 | ||
Causes | 458 | ||
Risks | 458 | ||
Diagnosis | 459 | ||
Per abdomen | 459 | ||
Per vaginam | 459 | ||
Progress and outcomes of labour | 459 | ||
Mentoanterior position | 459 | ||
Mentoposterior position | 459 | ||
Management of labour | 459 | ||
Brow presentation | 459 | ||
4A Puerperium—The Baby as a Neonate | 499 | ||
Section Contents | 499 | ||
48 Adaptation to extrauterine life 1 | 501 | ||
Chapter Contents | 501 | ||
Introduction | 501 | ||
The appearance of the normal neonate | 501 | ||
General appearance and the skin and hair at birth | 501 | ||
Posture and crying | 502 | ||
Eyes | 502 | ||
Ears | 502 | ||
Nose | 502 | ||
Mouth and throat | 502 | ||
Neck and chest | 503 | ||
Major systemic characteristics of the neonate | 503 | ||
The haematological system | 503 | ||
Circulatory volume | 503 | ||
Early versus delayed clamping of the umbilical cord | 503 | ||
Adaptations in the neonate’s haematological parameters | 503 | ||
The cardiovascular system | 504 | ||
The fundamentals of fetal circulation | 504 | ||
Résumé of cardiovascular and haemodynamic changes at birth | 507 | ||
The respiratory system | 507 | ||
Surfactant | 508 | ||
Onset of respirations | 508 | ||
The urinary system | 509 | ||
Postnatal development of the kidneys | 509 | ||
Neonatal renal physiology | 509 | ||
The urinary bladder and micturition | 509 | ||
Body composition | 510 | ||
Sexual characteristics | 510 | ||
References | 511 | ||
Annotated recommended reading | 512 | ||
49 Adaptation to extrauterine life 2 | 513 | ||
Chapter Contents | 513 | ||
Introduction | 513 | ||
The gastrointestinal tract | 513 | ||
Neonatal characteristics | 513 | ||
The oral cavity | 513 | ||
The stomach at birth | 513 | ||
Meconium | 514 | ||
The liver | 514 | ||
Metabolism | 514 | ||
Glucose metabolism | 514 | ||
Fat metabolism | 515 | ||
Protein metabolism | 515 | ||
Calcium, phosphorus and magnesium balance | 515 | ||
Calcium | 515 | ||
Neonatal aspects of calcium metabolism | 515 | ||
Phosphorus | 515 | ||
Magnesium | 515 | ||
The neonatal nervous system | 515 | ||
Autonomic functions | 516 | ||
Sensory functions | 516 | ||
Motor functions | 516 | ||
Ongoing neural development | 516 | ||
Reflexes | 516 | ||
Behavioural state regulation | 517 | ||
Sleep states | 517 | ||
Deep sleep | 517 | ||
Light sleep | 517 | ||
Awake states | 517 | ||
Drowsy state | 517 | ||
Quiet but alert state | 517 | ||
Active alert state | 517 | ||
Active crying state | 517 | ||
The essence of immunocompetence | 517 | ||
Gastrointestinal perspectives | 517 | ||
Thermoregulation | 517 | ||
Adult mechanisms | 518 | ||
Neonatal mechanisms | 518 | ||
Heat production and BAT | 518 | ||
Thermal care of the neonate | 518 | ||
References | 519 | ||
Annotated recommended reading | 519 | ||
50 Health challenges and problems in neonates of low birthweight | 521 | ||
Content Chapters | 521 | ||
Introduction | 521 | ||
Defining low birthweight | 521 | ||
Causes of low birthweight | 521 | ||
Assessment of gestational age | 521 | ||
The preterm neonate | 524 | ||
Characteristics of the premature neonate | 524 | ||
Causes of preterm birth | 526 | ||
Immediate management | 526 | ||
In labour | 527 | ||
At birth | 527 | ||
Ongoing care of premature neonates | 527 | ||
Potential problems | 527 | ||
Maintenance of temperature | 527 | ||
Respiration | 528 | ||
Oxygen therapy | 528 | ||
Nutrition | 528 | ||
Fats | 528 | ||
Proteins | 528 | ||
Carbohydrates | 528 | ||
Method of feeding | 528 | ||
Supplements | 529 | ||
Excretion | 529 | ||
Pain | 529 | ||
Environmental neonatology | 529 | ||
Noise | 529 | ||
Positioning | 530 | ||
Infection | 530 | ||
The small-for-gestational-age baby | 530 | ||
Asymmetrical growth retardation | 530 | ||
Symmetrical growth retardation | 531 | ||
Immediate management | 531 | ||
Labour and delivery | 531 | ||
Ongoing care of small-for-gestational age babies | 531 | ||
Transitional and follow-up care | 531 | ||
References | 531 | ||
Annotated recommended reading | 532 | ||
51 Developmental anatomy | 533 | ||
Chapter Contents | 533 | ||
Introduction | 533 | ||
Aspects of cardiovascular development | 533 | ||
Cardiovascular problems | 533 | ||
Cardiovascular abnormalities | 533 | ||
Risk factors | 534 | ||
Presenting features in a neonate | 534 | ||
Investigations | 534 | ||
Chest radiograph | 534 | ||
Electrocardiography | 534 | ||
Echocardiography | 534 | ||
Magnetic resonance imaging | 535 | ||
Cardiac catheterization and angiocardiography | 535 | ||
Arterial blood gases | 535 | ||
Some common disorders: acyanotic lesions | 535 | ||
Patent ductus arteriosus | 535 | ||
Ventricular septal defects | 535 | ||
Atrial septal defects | 536 | ||
Some common disorders: cyanotic lesions | 537 | ||
Transposition of the great arteries | 537 | ||
Total anomalous pulmonary venous drainage | 537 | ||
Tetralogy of Fallot | 537 | ||
Some common disorders: obstructive lesions | 538 | ||
Coarctation of the aorta | 538 | ||
Pulmonary valve stenosis and aortic valve stenosis | 538 | ||
Hypoplastic left heart syndrome | 538 | ||
Congestive cardiac failure | 539 | ||
Excessive volume overload | 539 | ||
Excessive pressure load | 539 | ||
Arrhythmias in the newborn | 539 | ||
Lower respiratory tract problems in neonates | 539 | ||
Respiratory distress syndrome | 539 | ||
Pathophysiology | 539 | ||
Clinical symptoms | 540 | ||
Management of respiratory distress syndrome | 540 | ||
Prebirth maternal treatment with corticosteroids | 540 | ||
Surfactant therapy | 540 | ||
Respiratory support. | 540 | ||
Bronchopulmonary dysplasia | 541 | ||
Meconium aspiration syndrome | 541 | ||
Pneumothorax | 541 | ||
Transient tachypnoea of the newborn | 541 | ||
Sudden infant death syndrome | 542 | ||
References | 542 | ||
Annotated recommended reading | 543 | ||
52 Jaundice and common metabolic problems in neonates | 545 | ||
Chapter Contents | 545 | ||
Introduction | 545 | ||
Neonatal jaundice | 545 | ||
Morphological factors | 545 | ||
Synthesis and metabolism of bilirubin | 545 | ||
Bilirubin in the neonate | 546 | ||
Kernicterus | 546 | ||
A résumé of common causes of neonatal jaundice | 547 | ||
Prehepatic: unconjugated bilirubin | 548 | ||
Hepatic: unconjugated bilirubin | 549 | ||
Hepatic: mixed unconjugated and conjugated bilirubin | 549 | ||
Posthepatic: mixed unconjugated and conjugated bilirubin | 549 | ||
Management of jaundice | 550 | ||
Investigations | 550 | ||
Phototherapy | 550 | ||
Use of immunoglobulin and exchange blood transfusion | 550 | ||
Common metabolic disorders | 550 | ||
Hypoglycaemia | 550 | ||
The clinical evidence | 551 | ||
Hypocalcaemia and hypomagnesaemia | 551 | ||
Associated hypomagnesaemia | 551 | ||
Hypernatraemia | 551 | ||
Signs of hypernatraemia | 552 | ||
References | 552 | ||
Annotated recommended reading | 553 | ||
53 Risks of infection and trauma in neonates | 555 | ||
Chapter Contents | 555 | ||
Infections | 555 | ||
Fetal and neonatal immunocompetence | 555 | ||
Perinatal and postnatal infections | 555 | ||
Skin and surface infections | 555 | ||
Serious infections | 556 | ||
Necrotizing enterocolitis | 556 | ||
Therapeutic interventions | 557 | ||
Gastroenteritis | 557 | ||
Birth trauma | 557 | ||
Head injuries | 557 | ||
Cephalhaematoma | 557 | ||
Subaponeurotic haemorrhage | 558 | ||
Intracranial haemorrhage | 558 | ||
Nerve palsies | 559 | ||
Facial palsy | 559 | ||
Erb’s palsy | 559 | ||
Klumpke’s palsy | 560 | ||
Soft tissue injuries | 560 | ||
References | 560 | ||
Annotated recommended reading | 561 | ||
4B Puerperium—The Mother | 563 | ||
Section Contents | 563 | ||
54 The breasts and lactation | 565 | ||
Chapter Contents | 565 | ||
Introduction | 565 | ||
The anatomy of the breast | 565 | ||
Situation, shape and size | 565 | ||
Internal structure | 565 | ||
The parenchyma | 565 | ||
The secretory cells | 566 | ||
The stroma | 566 | ||
The nipple and areola | 566 | ||
Blood and lymphatic supply | 566 | ||
Nerve supply | 567 | ||
Development of the breast | 567 | ||
Early development and puberty | 567 | ||
Development in pregnancy | 567 | ||
Maternal nutrition and lactation | 568 | ||
The physiology of lactation | 568 | ||
Neuroendocrine control | 569 | ||
Prolactin | 569 | ||
Oxytocin | 569 | ||
The effect of higher brain centres | 570 | ||
Autocrine control | 571 | ||
Suckling and removal of milk | 571 | ||
Breast milk | 572 | ||
The contents of breast milk | 572 | ||
Protein | 572 | ||
Carbohydrate | 572 | ||
Fats | 573 | ||
Variations in fat content of milk | 573 | ||
Electrolytes | 573 | ||
Minerals | 573 | ||
Trace elements | 573 | ||
Vitamins | 573 | ||
Enzymes | 573 | ||
Hormones | 573 | ||
Anti-infective factors | 573 | ||
The transmission of viruses in milk | 574 | ||
Anti-allergic properties | 574 | ||
References | 574 | ||
Annotated recommended reading | 575 | ||
55 Breastfeeding practice and problems | 577 | ||
Chapter Contents | 577 | ||
Introduction | 577 | ||
Benefits of breastfeeding | 577 | ||
Physiology applied to practice | 578 | ||
Antenatal preparation | 578 | ||
The first feed | 578 | ||
Positioning | 578 | ||
Attachment of the baby’s mouth to the breast | 579 | ||
Effective milk transfer | 579 | ||
Responsive feeding | 580 | ||
Breastfeeding problems | 580 | ||
Breast refusal | 580 | ||
Painful nipples | 580 | ||
Insufficient milk | 581 | ||
Full breasts and engorgement | 581 | ||
Mastitis | 581 | ||
Breast abscess | 581 | ||
Feeding after breast surgery | 582 | ||
Problems arising with the baby | 582 | ||
Congenital abnormalities in the baby | 582 | ||
Tongue-tie | 582 | ||
Prematurity in the baby | 582 | ||
Chemicals in breast milk | 583 | ||
Environmental toxins | 583 | ||
Medications | 583 | ||
Smoking | 583 | ||
Alcohol use | 583 | ||
Recreational drugs | 583 | ||
Suppression of lactation | 583 | ||
Lactation and fertility | 584 | ||
Modification of cow’s milk | 584 | ||
Differences between human and cow’s milk | 584 | ||
The manufacture of infant formulae | 584 | ||
References | 585 | ||
Annotated recommended reading | 586 | ||
56 The puerperium | 587 | ||
Chapter Contents | 587 | ||
Introduction | 587 | ||
Physiological changes | 587 | ||
Endocrine changes in the puerperium | 587 | ||
Resumption of menstruation and ovulation | 588 | ||
Involution | 588 | ||
Physiology | 589 | ||
Positional changes | 589 | ||
Uterine contractions | 589 | ||
The decidua | 589 | ||
Vaginal blood loss | 589 | ||
Other parts of the genital tract | 590 | ||
The body systems | 590 | ||
The cardiovascular and respiratory systems | 590 | ||
The renal system | 590 | ||
The gastrointestinal tract | 590 | ||
Postpartum (puerperal) infection | 590 | ||
Causative organisms | 590 | ||
Streptococci: Lancefield groups | 591 | ||
Sepsis | 591 | ||
Genital tract infection | 591 | ||
Postpartum endometritis | 592 | ||
Urinary tract infection | 592 | ||
Other postpartum (puerperal) infections | 592 | ||
Emotional states and mental disorders in the puerperium | 592 | ||
‘Baby blues’ | 593 | ||
Postnatal depression | 593 | ||
Risk factors | 593 | ||
Postpartum (puerperal) psychosis | 593 | ||
References | 594 | ||
Annotated recommended reading | 595 | ||
57 Biobehavioural aspects of parenting | 597 | ||
Chapter Outline | 597 | ||
Introduction | 597 | ||
What is biobehavioural science? | 597 | ||
What does biobehavioural mean in relation to early parenting? | 597 | ||
A hormonal orchestration | 597 | ||
A window of heightened sensitivity | 598 | ||
The key hormonal players | 598 | ||
Oxytocin | 598 | ||
Serotonin | 599 | ||
Vasopressin | 599 | ||
β-Endorphin | 599 | ||
Prolactin | 600 | ||
Catecholamines | 600 | ||
Cortisol | 600 | ||
The effects of stress and separation on attachment and bonding | 601 | ||
Implications for practice | 601 | ||
References | 602 | ||
Index | 605 | ||
A | 605 | ||
B | 606 | ||
C | 607 | ||
D | 609 | ||
E | 610 | ||
F | 611 | ||
G | 612 | ||
H | 613 | ||
I | 614 | ||
J | 615 | ||
K | 615 | ||
L | 615 | ||
M | 616 | ||
N | 617 | ||
O | 618 | ||
P | 618 | ||
R | 621 | ||
S | 622 | ||
T | 623 | ||
U | 624 | ||
V | 625 | ||
W | 625 | ||
X | 626 | ||
Y | 626 | ||
Z | 626 |