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Physiology in Childbearing E-Book

Physiology in Childbearing E-Book

Jean Rankin

(2017)

Additional Information

Book Details

Abstract

The new edition of Physiology in Childbearing with Anatomy and Related Biosciences continues to offer readers with a sound introduction to human biology as it relates to pregnancy and childbirth. The new edition retains the online question bank with downloadable image collection and is suitable for midwives – whether qualified or in training – throughout the world.

  • Straightforward writing style helps demystify a challenging subject area
  • Applies theory to practice to show how a knowledge of the biological sciences can enhance the care given to mothers and babies
  • Designed to facilitate early recognition of pathology to help prevent morbidity and mortality
  • Ideal introduction to basic biochemistry, cellular biology and genetics for those who have no prior knowledge of the subject areas
  • Chapters on embryology help explain the occurrence of neonatal pathology
  • A ‘body systems approach’ – including embryological development – enables an understanding of the physiological and pathophysiological changes that occur during pregnancy
  • Clear diagrams allow an understanding of the complex three-dimensional concepts seen in biology
  • Helpful pedagogy such as ‘Main Points’ boxes at the end of each chapter act as useful aide-memoires
  • Enhances the safety of mothers and babies, both in the developed world and those countries where the provision of adequate care remains limited
  • Revised contributor team provides an international perspective
  • Updated design presents shorter sections of information with concise summaries of ‘key points’ and easy to interpret figures and tables

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Half title page i
Dedication ii
Physiology in Childbearing iii
Copyright Page iv
Table Of Contents v
Contributors vii
Preface ix
Acknowledgements xi
Illustration Acknowledgements xiii
List of Abbreviations xv
2A Pregnancy—The Fetus 77
Section Contents 77
9 General embryology 79
Chapter Contents 79
Introduction 79
Embryology 79
Gametogenesis 79
Oogenesis 79
Spermatogenesis 79
Gamete size 80
Fertilization 81
Results of fertilization 81
The embryo 81
Terminology 81
Programming the embryo 81
Pattern formation 82
Early cell division–cleavage 82
Differentiation 83
Morphogenesis 83
Regulatory genes 83
The homeobox 84
Morphogens 84
Induction 84
Cell communication 84
Programmed cell death 85
Development of the embryo 85
The blastocyst 85
Implantation 85
The effects of enzymatic erosion 85
Development of the germ layers 85
The bilaminar embryonic disc 85
The trilaminar embryo 85
The primitive streak 86
Gastrulation 86
Development of body cavities 87
Formation of the notochord 87
Organogenesis 88
Differentiation of the germ layers 88
Ectoderm 88
Neurulation 88
Mesoderm 88
Endoderm 88
Folding of the embryo 88
Longitudinal folding 88
Transverse folding 88
References 92
Annotated recommended reading 92
10 Embryological systems 1—trunk, head and limbs 93
Chapter Contents 93
Introduction 93
The trunk 93
Skeletal features 93
The vertebral column 93
Precartilaginous phase 93
Cartilaginous phase 93
Bony phase 93
Ribs and sternum 93
Soft tissues 94
Myotomes 94
Dermatomes 94
The skin and mammary glands 94
The skull 94
The viscerocranium 94
The teeth 94
The brain 95
The changing shape of the brain 95
The forebrain 95
Other brain structures 95
Blood supply to the brain 95
The spinal cord 95
Zones of the spinal cord 95
Cells from the neural crest 95
Structures of the head and neck 96
Pharyngeal apparatus 96
Pharyngeal arches 96
The structure of the pharyngeal arches 96
Pharyngeal pouches and grooves 96
Derivatives of the pharyngeal arches 96
First pharyngeal arch 96
Second pharyngeal arch 96
Third pharyngeal arch 96
Fourth and sixth pharyngeal arches 96
Derivatives of the pharyngeal pouches 96
Derivatives of the pharyngeal grooves 98
The face 98
The ears 98
The outer and middle ear 98
The inner ear 98
The eyes 98
The optic cup 99
The eyelids and lacrimal apparatus 99
The limbs 99
Development of the limbs 99
Formation of the hands and feet 99
Development and rotation of the limbs 100
Muscles and nerves of the limbs 100
Blood supply to the limbs 100
References 101
Annotated recommended reading 101
11 Embryological systems 2—internal organs 103
Chapter Contents 103
Introduction 103
The cardiovascular system 103
Vasculogenesis and angiogenesis 103
The primordial cardiovascular system 103
Development of the heart 104
Blood flow through the early heart 104
Partitioning of the heart 105
The lower respiratory tract 105
Development of the laryngotracheal tube 105
Development of the lungs 105
The diaphragm 105
The alimentary tract 105
The foregut 106
The oesophagus 106
The stomach 106
The duodenum 106
The liver, gall bladder, pancreas and spleen 106
Development of the veins of the liver 106
The midgut 106
The hindgut: the rectum and anal canal 107
The urinary and genital tracts 107
The kidneys and ureters 107
Development of the collecting system 107
The bladder and urethra 107
The suprarenal glands 108
The reproductive system 108
Testes and the male genital tract 108
Ovaries and the female genital tract 108
The vagina 109
The external genitalia 109
Estimation of embryonic age 109
References 109
Annotated recommended reading 110
12 The placenta, membranes and amniotic fluid 111
Chapter Contents 111
Introduction 111
Implantation 111
Development of the chorionic villi 111
Formation of the cytotrophoblastic shell 112
Later placental development 112
The mature placenta 112
Appearance 112
The membranes 115
The umbilical cord 115
The umbilical vesicle (yolk sac) and allantois 115
The placental circulation 116
Anatomical variations of the placenta 116
Functions of the placenta 116
Endocrine function 118
The protein hormones 119
The steroid hormones: oestrogens 119
Oestrogen levels in normal pregnancy 119
The steroid hormones: progesterone 119
The function of progesterone in pregnancy 119
Progesterone levels in normal and abnormal pregnancy 120
Transfer of substances 120
Mechanisms of transfer 120
Respiration 120
Fetal oxygen supply 120
Carbon dioxide 120
Nutrition 120
Carbohydrate transfer 120
Amino acid transfer 120
Lipid transfer 121
Vitamin transfer 121
Trace element transfer 121
Water and electrolyte transfer 121
Excretion 121
Protection 121
Immunological role 121
Amniotic fluid 121
Production of amniotic fluid 121
Sources of amniotic fluid 121
Circulation of amniotic fluid 121
Content of amniotic fluid 121
Regulation of amniotic fluid quantity 121
Functions of amniotic fluid 122
Clinical implications: abnormalities of quantity 122
Polyhydramnios 122
Oligohydramnios 122
Diagnostic uses of amniotic fluid 123
Biophysical profile 123
Amniocentesis 123
References 124
Annotated recommended reading 124
13 Fetal growth and development 125
Chapter Contents 125
Introduction 125
The fetal period 125
Fetal growth 125
Control of cell growth and proliferation 125
Key events in the fetal stage of development 125
Fetal size 125
Estimation of fetal age and assessment of fetal growth 127
Growth curves 127
Maternal weight and fetal growth 127
Ultrasound 130
Linear measurements 130
Non-linear measurements 130
Ratios 130
Doppler wave form analysis 130
Multiple pregnancies 130
Types of twin pregnancy 130
Dizygotic 130
Monozygotic 130
The incidence of multiple pregnancies 131
Triplets and higher-order pregnancies 131
Diagnosis of twin pregnancy 132
Abdominal examination 132
Inspection 132
Palpation 132
Auscultation 132
Ultrasound 132
Complications of pregnancy 132
Fetal problems 132
Abortion (Miscarriage) 132
Single fetus demise 132
Congenital malformations 132
Monoamniotic twins 132
Conjoined twins 132
Acardiac twinning 133
Twin–twin transfusion syndrome 133
Polyhydramnios 134
Intrauterine growth retardation 134
Maternal problems 134
Exacerbation of minor disorders 134
Anaemia 134
Pregnancy-induced hypertension 134
Antepartum haemorrhage 134
Complications of labour 134
Fetal malpresentations 134
Locked twins 134
Umbilical cord problems 134
Preterm onset of labour 135
Mode of delivery 135
Postpartum haemorrhage 135
Undiagnosed twins 135
Postnatal care of mother and babies 135
Care of the babies 135
Care of the mother 135
References 135
Annotated recommended reading 136
14 Common fetal problems 137
Chapter Contents 137
Introduction 137
Intrauterine growth retardation 137
Complications of IUGR 137
Factors adversely affecting fetal growth 137
Maternal malnutrition 137
Smoking 138
Alcohol consumption 138
Placental insufficiency 138
Multiple pregnancy 138
Genetic factors and chromosomal aberrations 138
Diagnosis and management of IUGR 138
Delivery of the baby 138
Rhesus isoimmunization and ABO incompatibility 138
Rhesus isoimmunization (RhD incompatibility) 138
Prevention of maternal isoimmunization 139
Antenatal management: anti-D prophylaxis 139
Care at delivery 139
Management if rhesus antibodies are present during pregnancy 139
Rhesus haemolytic disease 139
ABO incompatibility 139
Maternal infection in pregnancy 140
Suppression of cell-mediated immunity 140
Sexually transmitted diseases 140
Bacterial infections 140
Gonorrhoea 140
Syphilis 140
Chlamydia 140
Group B streptococcus 140
Viral infections 140
Human immunodeficiency virus 140
TORCH organisms and pregnancy risk 141
Rubella 141
Varicella 141
Cytomegalovirus 141
Toxoplasmosis 141
Herpes simplex 141
Listeriosis 142
Hepatitis B (serum hepatitis) 142
Hepatitis C 142
References 143
Annotated recommended reading 143
15 Congenital anomalies 145
Chapter Contents 145
Introduction 145
General causes of congenital anomalies 145
Genetic causes 145
Chromosomal abnormalities 145
Down syndrome 146
Single gene disorders 147
Cystic fibrosis 147
Multifactorial inheritance 148
Cleft lip and cleft palate 148
Neural Tube Defects 148
Environmental factors 149
Teratogens 149
Drugs 150
Prenatal screening for congenital anomalies 150
Ultrasonography 150
Obtaining fetal tissue for genetic testing 150
Amniocentesis 151
Chorionic villus sampling 151
Fetal blood sampling 151
Non-invasive prenatal testing 151
Conclusion 151
References 151
Annotated recommended reading 152
2B Pregnancy—The Mother 153
Section Contents 153
16 The haematological system—physiology of the blood 155
Chapter Contents 155
Blood as a tissue 155
Functions of blood 155
Constituents of blood 155
Plasma 156
The cellular components of blood 156
Red blood cells 157
Haemoglobin 157
Formation of erythrocytes 158
The life span of red cells 158
Iron metabolism 158
Absorption 158
Serum iron, transferrin and total iron-binding capacity 159
Serum ferritin 159
Marrow iron 159
Folate metabolism 159
Blood groups 159
The ABO system 159
The rhesus (Rh) system 159
White cells 160
Types of white cells 160
The production of granulocytes 160
Agranulocytes 160
Lymphocytes 160
Monocytes 160
Platelets 160
Haemostasis 161
Vascular spasm 161
Formation of a platelet plug 161
Coagulation 161
Clot retraction and fibrinolysis 162
Factors limiting clot growth or formation 162
Maternal haematological adaptations to pregnancy 162
Blood volume and composition 162
Plasma volume 163
Blood cellular components 163
Iron requirements during pregnancy 163
Folate metabolism in pregnancy 163
Haemostasis in pregnancy 163
Intrapartum and immediate postpartum periods 164
References 166
Annotated recommended reading 166
Website 166
17 The cardiovascular system 167
Chapter Contents 167
Introduction 167
Circulatory pathways 167
Anatomy of the heart 167
Description 167
Layers 168
Chambers and valves 169
The atrioventricular valves 169
The semilunar valves 169
The coronary circulation 169
Pulmonary and systemic circulations 169
Physiology of the heart 169
The electrical conducting system (nodal system) 170
The cardiac cycle 170
Control of the heart rate 170
Intrinsic control 170
Extrinsic control 170
Nervous control 170
Hormonal control 171
Stretch 171
Stroke volume 171
Cardiac output 172
Other influences 172
The vascular system 172
Structure of blood vessels 172
The arterial system 172
Elastic arteries (conducting arteries) 172
Muscular arteries (distributing arteries) 172
Arterioles 172
Capillaries 172
The microcirculation 173
The venous system 174
The physiology of circulation 175
Blood vessel diameter 175
Nervous control 175
Chemical control 175
Endothelial-mediated regulation 175
Blood pressure 175
Fluid pressure 175
Fluid flow 176
Venous return 176
Arterial blood pressure 176
Pulse pressure and mean arterial pressure 176
The regulation of blood pressure 176
Neural system 176
Chemical control 177
The renal system 177
Blood pressure values 177
The formation of tissue fluid 178
Hydrostatic pressure 178
Osmotic pressure 178
Diffusion 178
Maternal adaptations to pregnancy 179
Haemodynamic changes 179
Size and position of the heart 179
Control of cardiovascular changes 180
References 181
Annotated recommended reading 181
18 Respiration 183
Chapter Contents 183
Introduction 183
Anatomy of the respiratory system 183
The upper airways 183
The lower respiratory tract 184
The thoracic cage 185
Physiology of the respiratory tract 185
The epithelial lining 185
Reflex mechanisms 185
Structure and function of the alveoli 185
Surfactant 186
Blood supply to the lungs 186
Nerve supply to the respiratory muscles 186
The physiology of pulmonary ventilation (breathing) 186
Mechanical factors 186
Inspiration 187
Expiration 187
Pulmonary ventilation 187
Respiratory parameters 187
Respiratory volumes 187
Respiratory capacities 187
Minute volume 187
Alveolar ventilation 188
Transport of gases around the body 188
Gas exchange in tissues 188
Transport of oxygen 188
Partial pressure gradients and gas diffusion 188
The oxygen dissociation curve 188
Factors influencing the oxygen–haemoglobin dissociation curve 188
Increase in carbon dioxide 188
Increase in hydrogen ions 189
Increase in 2,3-diphosphoglycerate 189
Increase in temperature 189
Carbon monoxide 189
Transport of carbon dioxide 189
Bicarbonate ions 189
The chloride shift 189
Hydrogen ions, carbon dioxide and the acid–base balance 189
Control of ventilation 190
Medullary respiratory centres 190
The dorsal respiratory group 190
The respiratory cycle 190
Factors influencing the rate and depth of breathing 190
Voluntary control of breathing 190
Chemoreceptor effects 190
The Hering–Breuer reflex 190
Maternal adaptations to pregnancy 190
Upper respiratory tract changes 190
Anatomical changes 190
Biochemical changes 191
Carbon dioxide 191
Oxygen 192
Postpartum changes 192
References 194
Annotated recommended reading 194
Website 194
19 The renal tract 195
Chapter Contents 195
Introduction 195
Kidney functions 195
Anatomy of the kidney 195
Structure 195
Microscopic structure of the kidney 196
The role of blood pressure 197
Renal function 197
The production of urine 197
Glomerular filtration 197
Tubular reabsorption and secretion 198
Hormones influencing selective reabsorption 198
Regulation of urine concentration and volume 199
Formation of concentrated urine 202
The lower urinary tract 202
The ureters 202
2C Pregnancy–The Problems 315
Section Contents 315
30 Minor disorders of pregnancy 317
Chapter Contents 317
Introduction 317
Maintenance of pregnancy 317
Minor disorders of pregnancy 317
The digestive system 317
Nausea and vomiting 317
Heartburn 318
Ptyalism 318
Pica 318
Constipation 318
Skin 319
The cardiovascular system 319
Fainting 319
Varicosities 319
The musculoskeletal system 319
Backache 319
The nervous system 319
Carpal tunnel syndrome 319
Fatigue and emotional changes 320
The genitourinary system 320
Frequency of micturition 320
Leucorrhoea 320
Conclusion 320
References 320
Annotated recommended reading 321
31 Bleeding in pregnancy 323
Chapter Contents 323
Bleeding in early pregnancy 323
Implantation bleeding 323
Miscarriage (abortion) 323
Classification of miscarriage (abortion) 323
Threatened miscarriage 323
Inevitable miscarriage 324
Missed miscarriage 324
Recurrent miscarriage 324
Induced abortion (therapeutic) 324
Gestational trophoblastic tumours 325
Hydatidiform mole 325
Aetiology 325
Signs and symptoms 325
Management 325
Choriocarcinoma and placental site tumours 325
Treatment 326
Ectopic pregnancy 326
Tubal pregnancy 326
Risk factors 326
Pathophysiology 326
Diagnosis 326
Management 327
Prognosis 327
Bleeding from associated conditions 327
Cervical polyps 327
Cervical erosion 327
Carcinoma of the cervix 327
Cervical intraepithelial neoplasia 327
Invasive carcinoma of the cervix 328
Vaginitis 328
Antepartum haemorrhage 328
Placenta praevia 328
Classification of placenta praevia 328
Aetiology of placenta praevia 329
Blood loss 329
Management 329
General examination 329
Abdominal examination 329
Conservative management 329
Delivery 329
Active management 329
Third stage 329
Placental abruption (abruptio placentae) 329
Risk factors 330
Blood loss 330
Management of placental abruption 331
Blood coagulation disorders 331
Other complications 331
Vasa praevia 332
References 332
Annotated recommended reading 333
32 Cardiac and hypertensive disorders 335
Chapter Contents 335
Introduction 335
Cardiac disorders in pregnancy 335
Risk factors 335
Main types of cardiac disorder 336
Congenital heart disease 336
Categorization of congenital heart disease 336
Eisenmenger’s syndrome 336
Marfan’s syndrome 336
Assessment of mothers with heart disease 336
New York Heart Association classification 336
Management of women with heart disease 336
Specific aspects of care 336
Intrapartum care 336
Second stage 337
Third stage 337
Postnatal care 337
Hypertension in pregnancy 337
Terminology 337
Classification 337
Incidence 337
Pathogenesis 337
Outcomes 338
Eclampsia 338
Prediction 338
HELLP syndrome 338
Management of hypertensive conditions 338
Rest and observation 338
Fetal observations 339
Delivery 339
Control of blood pressure 339
Anticonvulsive therapy 339
Prevention 339
References 340
Annotated recommended reading 341
33 Anaemia and clotting disorders 343
Chapter Contents 343
Anaemia 343
Recognition and incidence of anaemia 343
Iron-deficiency anaemia 343
Pathology 343
Folic acid–deficiency anaemia and the role of vitamins 343
Management 345
Haemoglobinopathies 345
The globin chains 345
Sickle cell disease 347
Pathophysiology 347
Thalassaemia 347
Glucose-6-phosphate dehydrogenase deficiency 348
Thromboembolism and pregnancy 348
Superficial thrombophlebitis 348
Deep vein thrombosis 348
Factors associated with pregnancy predisposing to thromboembolism 348
Pathogenesis 348
3A Labour–Normal 371
Section Contents 371
36 The onset of labour 373
Chapter Contents 373
Introduction 373
The onset of labour 373
Fetal factors associated with the onset of labour 373
The role of the fetal hypothalamus– pituitary–adrenal axis 373
The fetal posterior pituitary gland 375
The role of the placenta (Fig. 36.3) 375
Progesterone 375
Oestrogens 375
Fetal membranes 375
Prostaglandins 375
Maternal influences 376
The endocrine system 376
Neurohormonal control 376
Control of cervical changes in labour 376
Definitions of labour 377
Maternal physiological adaptation in labour 378
Cardiovascular system 378
Haematological system 378
Respiratory system 378
Maternal acidosis 378
Maternal alkalosis 378
Renal system 379
Gastrointestinal system 379
Gastric emptying 379
Metabolism 379
Clinical implications 379
Recognition of the onset of labour 379
Initial examination of the woman 379
The history 379
General examination 379
Assessing progress in labour 380
References 380
Annotated recommended reading 380
37 The first stage of labour 381
Chapter Contents 381
Physiology of the first stage of labour 381
Uterine activity in labour 381
Mechanical factors 381
Phases of the first stage of labour 383
Individualized care 383
Assessing progress in the first stage of labour 384
Abdominal examination in labour 384
Vaginal examination in labour 384
Maternal position in the first stage of labour 388
Immersion in water 390
Nutrition and hydration in labour 390
Nutrition 390
Hydration 390
Monitoring the fetal condition 391
The fetus in the first stage of labour 391
Heart rate 392
Intermittent monitoring 392
Continuous fetal heart recording 392
Telemetry 393
Findings 393
Baseline fetal heart rate 393
Baseline variability 393
Response of the fetal heart to uterine contractions 394
Fetal blood sampling 395
Amniotic fluid 396
References 397
Annotated recommended reading 397
38 Pain relief in labour 399
Chapter Contents 399
Introduction 399
Pain perception 399
Pain reception 399
Classification of pain 399
Pain pathways 400
The anatomy of the dorsal horn 400
Ascending pathways 400
Pain modulation 400
Control systems descending from the brain 400
The gate control theory of pain 400
Visceral sensory neurons 401
Pain pathways in labour 401
The effect of pain 402
Management of pain 403
Working with pain model 403
Non-pharmacological support 403
Transcutaneous electrical nerve stimulation 404
Systemic analgesia 405
Inhalational analgesia 405
Stages of anaesthesia 406
Obstetric use of inhalational anaesthetics 406
Epidural analgesia 406
Anatomy of the epidural space 406
Indications for epidural analgesia 407
Contraindications 407
Other drugs 409
Spinal anaesthesia 409
Pudendal block 409
Perineal infiltration 409
References 410
Annotated recommended reading 410
Website 410
39 The second stage of labour 411
Chapter Contents 411
Introduction 411
Physiology of the second stage of labour 411
Contractions 411
The secondary powers 411
Descent of the fetus 411
Onset of the second stage 411
Duration of the second stage 411
Mechanisms of labour 412
The mechanism of a normal labour 413
The movements 413
Physiological changes 413
The length of the second stage of labour 415
Management 415
Position of the woman 415
Squatting 415
Hands and knees/all-fours positions 415
Birthing chairs 416
Review of upright positions 416
Maternal effort in the second stage of labour 416
Effect on pelvic soft tissues 416
Perineal lacerations 416
The episiotomy 416
Recommendations for performing an episiotomy 417
The incision 417
Suturing the perineum 418
Infiltration of the perineum 418
Obstetric anal sphincter injuries 418
The fetus in the second stage of labour 418
References 420
Annotated recommended reading 420
40 The third stage of labour 421
Chapter Contents 421
Introduction 421
Physiology of the third stage of labour 421
Separation of the placenta 421
Control of bleeding 421
Management of the third stage of labour 422
The development and use of oxytocic drugs to manage the third stage of labour 423
Active versus physiological management 423
Syntometrine versus oxytocin 424
Examination of the placenta 424
References 425
Annotated recommended reading 426
3B Labour—Problems 427
Section Contents 427
41 Abnormalities of uterine action and onset of labour 429
Chapter Contents 429
Introduction 429
Abnormalities of uterine action 429
Prolonged labour 429
Timing of the onset of labour 429
Latent or active phase? 430
Inefficient uterine action 430
Hypotonic uterine action 430
Incoordinate uterine action 430
Active management of labour 430
Augmentation of labour 431
Amniotomy 431
Oxytocic infusion 431
Prolonged second stage of labour 431
Management 431
Over-efficient uterine action 431
Precipitate labour 431
Dangers of precipitate labour 431
Tonic contraction of the uterus 433
Cervical dystocia 433
Problems: timing of the onset of labour 433
Preterm onset of labour 433
Aetiology 433
Fetal fibronectin 433
Preterm rupture of the membranes 433
The use of drugs in preterm onset of labour and preterm rupture of the membranes 434
Corticosteroids 434
Antibiotics 434
Tocolytic drugs 434
Labour and delivery 435
Prolonged pregnancy 435
Risk factors 435
Management of post-term pregnancy 435
Induction of labour 436
Methods 436
Cervical ripening 436
Prostaglandins 436
Mechanical methods for induction of labour 437
Sweeping the membranes 437
Amniotomy with or without oxytocin 437
References 438
Annotated recommended reading 439
42 Breech presentation 441
Chapter Contents 441
Introduction 441
Breech presentation 441
Types of breech presentation 441
Aetiology 441
Diagnosis of breech presentation 441
On discussion 441
On abdominal examination 441
On vaginal examination 443
Ultrasound scan 443
Associated risk factors 443
Congenital abnormality 443
Risks at delivery 443
Management of pregnancy 443
Cephalic version 444
Promotion of spontaneous cephalic version 444
Moxibustion 444
External cephalic version 444
The procedure for ECV 444
The role of planned caesarean section at term 445
Vaginal delivery 446
Management 446
The mechanism of a breech delivery 446
The movements 446
Compaction and flexion 446
Internal rotation of the buttocks 446
Lateral flexion of the trunk 446
Restitution 446
Internal rotation of the shoulders 446
Birth of the shoulders 447
Internal rotation and delivery of the head 447
The first stage of labour 447
The second stage of labour 447
Vaginal breech birth 447
Assisted breech delivery 447
The buttocks 447
Extended legs 448
The body 448
The arms 448
Extended arms 448
The head 448
Mauriceau–Smellie–Veit (modified) manoeuvre 449
Burns–Marshall manoeuvre 449
Entrapment of the fetal head 450
Undiagnosed cephalopelvic disproportion 450
Posterior rotation of the occiput 450
References 450
Annotated recommended reading 451
43 Malposition and cephalic malpresentations 453
Chapter Contents 453
Introduction 453
Occipitoposterior position of the vertex 453
Causes 453
Attitude 453
Diagnosis in pregnancy 453
Diagnosis in labour 453
The first stage of labour 453
The role of maternal position 454
The second stage of labour 456
Deep transverse arrest of the head 456
Diagnosis and management 456
Short internal rotation of sinciput and ‘face to pubes’ delivery 458
Diagnosis 458
Management of the spontaneous delivery 458
Face presentation 458
Causes 458
Risks 458
Diagnosis 459
Per abdomen 459
Per vaginam 459
Progress and outcomes of labour 459
Mentoanterior position 459
Mentoposterior position 459
Management of labour 459
Brow presentation 459
4A Puerperium—The Baby as a Neonate 499
Section Contents 499
48 Adaptation to extrauterine life 1 501
Chapter Contents 501
Introduction 501
The appearance of the normal neonate 501
General appearance and the skin and hair at birth 501
Posture and crying 502
Eyes 502
Ears 502
Nose 502
Mouth and throat 502
Neck and chest 503
Major systemic characteristics of the neonate 503
The haematological system 503
Circulatory volume 503
Early versus delayed clamping of the umbilical cord 503
Adaptations in the neonate’s haematological parameters 503
The cardiovascular system 504
The fundamentals of fetal circulation 504
Résumé of cardiovascular and haemodynamic changes at birth 507
The respiratory system 507
Surfactant 508
Onset of respirations 508
The urinary system 509
Postnatal development of the kidneys 509
Neonatal renal physiology 509
The urinary bladder and micturition 509
Body composition 510
Sexual characteristics 510
References 511
Annotated recommended reading 512
49 Adaptation to extrauterine life 2 513
Chapter Contents 513
Introduction 513
The gastrointestinal tract 513
Neonatal characteristics 513
The oral cavity 513
The stomach at birth 513
Meconium 514
The liver 514
Metabolism 514
Glucose metabolism 514
Fat metabolism 515
Protein metabolism 515
Calcium, phosphorus and magnesium balance 515
Calcium 515
Neonatal aspects of calcium metabolism 515
Phosphorus 515
Magnesium 515
The neonatal nervous system 515
Autonomic functions 516
Sensory functions 516
Motor functions 516
Ongoing neural development 516
Reflexes 516
Behavioural state regulation 517
Sleep states 517
Deep sleep 517
Light sleep 517
Awake states 517
Drowsy state 517
Quiet but alert state 517
Active alert state 517
Active crying state 517
The essence of immunocompetence 517
Gastrointestinal perspectives 517
Thermoregulation 517
Adult mechanisms 518
Neonatal mechanisms 518
Heat production and BAT 518
Thermal care of the neonate 518
References 519
Annotated recommended reading 519
50 Health challenges and problems in neonates of low birthweight 521
Content Chapters 521
Introduction 521
Defining low birthweight 521
Causes of low birthweight 521
Assessment of gestational age 521
The preterm neonate 524
Characteristics of the premature neonate 524
Causes of preterm birth 526
Immediate management 526
In labour 527
At birth 527
Ongoing care of premature neonates 527
Potential problems 527
Maintenance of temperature 527
Respiration 528
Oxygen therapy 528
Nutrition 528
Fats 528
Proteins 528
Carbohydrates 528
Method of feeding 528
Supplements 529
Excretion 529
Pain 529
Environmental neonatology 529
Noise 529
Positioning 530
Infection 530
The small-for-gestational-age baby 530
Asymmetrical growth retardation 530
Symmetrical growth retardation 531
Immediate management 531
Labour and delivery 531
Ongoing care of small-for-gestational age babies 531
Transitional and follow-up care 531
References 531
Annotated recommended reading 532
51 Developmental anatomy 533
Chapter Contents 533
Introduction 533
Aspects of cardiovascular development 533
Cardiovascular problems 533
Cardiovascular abnormalities 533
Risk factors 534
Presenting features in a neonate 534
Investigations 534
Chest radiograph 534
Electrocardiography 534
Echocardiography 534
Magnetic resonance imaging 535
Cardiac catheterization and angiocardiography 535
Arterial blood gases 535
Some common disorders: acyanotic lesions 535
Patent ductus arteriosus 535
Ventricular septal defects 535
Atrial septal defects 536
Some common disorders: cyanotic lesions 537
Transposition of the great arteries 537
Total anomalous pulmonary venous drainage 537
Tetralogy of Fallot 537
Some common disorders: obstructive lesions 538
Coarctation of the aorta 538
Pulmonary valve stenosis and aortic valve stenosis 538
Hypoplastic left heart syndrome 538
Congestive cardiac failure 539
Excessive volume overload 539
Excessive pressure load 539
Arrhythmias in the newborn 539
Lower respiratory tract problems in neonates 539
Respiratory distress syndrome 539
Pathophysiology 539
Clinical symptoms 540
Management of respiratory distress syndrome 540
Prebirth maternal treatment with corticosteroids 540
Surfactant therapy 540
Respiratory support. 540
Bronchopulmonary dysplasia 541
Meconium aspiration syndrome 541
Pneumothorax 541
Transient tachypnoea of the newborn 541
Sudden infant death syndrome 542
References 542
Annotated recommended reading 543
52 Jaundice and common metabolic problems in neonates 545
Chapter Contents 545
Introduction 545
Neonatal jaundice 545
Morphological factors 545
Synthesis and metabolism of bilirubin 545
Bilirubin in the neonate 546
Kernicterus 546
A résumé of common causes of neonatal jaundice 547
Prehepatic: unconjugated bilirubin 548
Hepatic: unconjugated bilirubin 549
Hepatic: mixed unconjugated and conjugated bilirubin 549
Posthepatic: mixed unconjugated and conjugated bilirubin 549
Management of jaundice 550
Investigations 550
Phototherapy 550
Use of immunoglobulin and exchange blood transfusion 550
Common metabolic disorders 550
Hypoglycaemia 550
The clinical evidence 551
Hypocalcaemia and hypomagnesaemia 551
Associated hypomagnesaemia 551
Hypernatraemia 551
Signs of hypernatraemia 552
References 552
Annotated recommended reading 553
53 Risks of infection and trauma in neonates 555
Chapter Contents 555
Infections 555
Fetal and neonatal immunocompetence 555
Perinatal and postnatal infections 555
Skin and surface infections 555
Serious infections 556
Necrotizing enterocolitis 556
Therapeutic interventions 557
Gastroenteritis 557
Birth trauma 557
Head injuries 557
Cephalhaematoma 557
Subaponeurotic haemorrhage 558
Intracranial haemorrhage 558
Nerve palsies 559
Facial palsy 559
Erb’s palsy 559
Klumpke’s palsy 560
Soft tissue injuries 560
References 560
Annotated recommended reading 561
4B Puerperium—The Mother 563
Section Contents 563
54 The breasts and lactation 565
Chapter Contents 565
Introduction 565
The anatomy of the breast 565
Situation, shape and size 565
Internal structure 565
The parenchyma 565
The secretory cells 566
The stroma 566
The nipple and areola 566
Blood and lymphatic supply 566
Nerve supply 567
Development of the breast 567
Early development and puberty 567
Development in pregnancy 567
Maternal nutrition and lactation 568
The physiology of lactation 568
Neuroendocrine control 569
Prolactin 569
Oxytocin 569
The effect of higher brain centres 570
Autocrine control 571
Suckling and removal of milk 571
Breast milk 572
The contents of breast milk 572
Protein 572
Carbohydrate 572
Fats 573
Variations in fat content of milk 573
Electrolytes 573
Minerals 573
Trace elements 573
Vitamins 573
Enzymes 573
Hormones 573
Anti-infective factors 573
The transmission of viruses in milk 574
Anti-allergic properties 574
References 574
Annotated recommended reading 575
55 Breastfeeding practice and problems 577
Chapter Contents 577
Introduction 577
Benefits of breastfeeding 577
Physiology applied to practice 578
Antenatal preparation 578
The first feed 578
Positioning 578
Attachment of the baby’s mouth to the breast 579
Effective milk transfer 579
Responsive feeding 580
Breastfeeding problems 580
Breast refusal 580
Painful nipples 580
Insufficient milk 581
Full breasts and engorgement 581
Mastitis 581
Breast abscess 581
Feeding after breast surgery 582
Problems arising with the baby 582
Congenital abnormalities in the baby 582
Tongue-tie 582
Prematurity in the baby 582
Chemicals in breast milk 583
Environmental toxins 583
Medications 583
Smoking 583
Alcohol use 583
Recreational drugs 583
Suppression of lactation 583
Lactation and fertility 584
Modification of cow’s milk 584
Differences between human and cow’s milk 584
The manufacture of infant formulae 584
References 585
Annotated recommended reading 586
56 The puerperium 587
Chapter Contents 587
Introduction 587
Physiological changes 587
Endocrine changes in the puerperium 587
Resumption of menstruation and ovulation 588
Involution 588
Physiology 589
Positional changes 589
Uterine contractions 589
The decidua 589
Vaginal blood loss 589
Other parts of the genital tract 590
The body systems 590
The cardiovascular and respiratory systems 590
The renal system 590
The gastrointestinal tract 590
Postpartum (puerperal) infection 590
Causative organisms 590
Streptococci: Lancefield groups 591
Sepsis 591
Genital tract infection 591
Postpartum endometritis 592
Urinary tract infection 592
Other postpartum (puerperal) infections 592
Emotional states and mental disorders in the puerperium 592
‘Baby blues’ 593
Postnatal depression 593
Risk factors 593
Postpartum (puerperal) psychosis 593
References 594
Annotated recommended reading 595
57 Biobehavioural aspects of parenting 597
Chapter Outline 597
Introduction 597
What is biobehavioural science? 597
What does biobehavioural mean in relation to early parenting? 597
A hormonal orchestration 597
A window of heightened sensitivity 598
The key hormonal players 598
Oxytocin 598
Serotonin 599
Vasopressin 599
β-Endorphin 599
Prolactin 600
Catecholamines 600
Cortisol 600
The effects of stress and separation on attachment and bonding 601
Implications for practice 601
References 602
Index 605
A 605
B 606
C 607
D 609
E 610
F 611
G 612
H 613
I 614
J 615
K 615
L 615
M 616
N 617
O 618
P 618
R 621
S 622
T 623
U 624
V 625
W 625
X 626
Y 626
Z 626