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Diagnostic Pathology: Thoracic E-Book

Diagnostic Pathology: Thoracic E-Book

Saul Suster | Cesar A. Moran

(2017)

Additional Information

Book Details

Abstract

Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of thoracic pathology. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.

  • Unsurpassed visual coverage, with carefully annotated gross pathology, histopathology, special stains, and correlative radiologic images that provide clinically and diagnostically important information.
  • Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases.
  • Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index.
  • Thoroughly updated content throughout, reflecting new WHO classifications of adenocarcinoma of the lung and a proliferation of molecular markers.
  • New coverage of targeted therapies in molecular testing that determine why, when, and where these precisely classified lung cancers are found and their biologic behavior.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Diagnostic Pathology: Thoracic iii
Copyright Page iv
Dedications v
Preface vii
Acknowledgments ix
Sections xi
Table of Contents xii
Part I: Lung 3
SECTION 1: Neoplasms, Benign 3
Chapter 1. Cartilaginous Hamartoma 4
TERMINOLOGY 5
ETIOLOGY/PATHOGENESIS 5
CLINICAL ISSUES 5
MACROSCOPIC 5
MICROSCOPIC 5
DIFFERENTIAL DIAGNOSIS 5
Part II: Pleura 553
SECTION 1:\rNeoplasms, Benign 553
Chapter\r114. Mesothelial Hyperplasia 554
TERMINOLOGY 555
ETIOLOGY/PATHOGENESIS 555
CLINICAL ISSUES 555
MICROSCOPIC 555
DIFFERENTIAL DIAGNOSIS 555
DIAGNOSTIC CHECKLIST 555
SELECTED REFERENCES 555
Chapter\r115. Solitary Fibrous Tumor 558
TERMINOLOGY 559
ETIOLOGY/PATHOGENESIS 559
CLINICAL ISSUES 559
MACROSCOPIC 559
MICROSCOPIC 559
ANCILLARY TESTS 559
DIFFERENTIAL DIAGNOSIS 559
DIAGNOSTIC CHECKLIST 560
SELECTED REFERENCES 560
Chapter\r116. Calcified Fibrous Pseudotumor 568
TERMINOLOGY 569
ETIOLOGY/PATHOGENESIS 569
CLINICAL ISSUES 569
MACROSCOPIC 569
MICROSCOPIC 569
DIFFERENTIAL DIAGNOSIS 569
DIAGNOSTIC CHECKLIST 569
SELECTED REFERENCES 569
SECTION 2:\rNeoplasms, Malignant, Primary 573
Epithelial Neoplasms 574
Chapter\r117. Overview of Malignant Pleural Neoplasms 574
TERMINOLOGY 574
ETIOLOGY/PATHOGENESIS 574
EPIDEMIOLOGY 574
CLINICAL IMPLICATIONS 574
MACROSCOPIC 575
MICROSCOPIC 575
SELECTED REFERENCES 575
Chapter\r118. Malignant Mesothelioma 576
TERMINOLOGY 577
ETIOLOGY/PATHOGENESIS 577
CLINICAL ISSUES 577
MACROSCOPIC 577
MICROSCOPIC 577
ANCILLARY TESTS 577
DIFFERENTIAL DIAGNOSIS 577
DIAGNOSTIC CHECKLIST 578
SELECTED REFERENCES 578
Chapter\r119. Pseudomesotheliomatous Adenocarcinoma 584
TERMINOLOGY 585
ETIOLOGY/PATHOGENESIS 585
CLINICAL ISSUES 585
IMAGING 585
MACROSCOPIC 585
MICROSCOPIC 585
DIFFERENTIAL DIAGNOSIS 585
DIAGNOSTIC CHECKLIST 585
SELECTED REFERENCES 585
Chapter\r120. Mucoepidermoid Carcinoma of Pleura 590
TERMINOLOGY 591
ETIOLOGY/PATHOGENESIS 591
CLINICAL ISSUES 591
IMAGING 591
MACROSCOPIC 591
MICROSCOPIC 591
DIFFERENTIAL DIAGNOSIS 591
DIAGNOSTIC CHECKLIST 591
SELECTED REFERENCES 591
Chapter\r121. Angiosarcoma 596
TERMINOLOGY 597
ETIOLOGY/PATHOGENESIS 597
CLINICAL ISSUES 597
MACROSCOPIC 597
MICROSCOPIC 597
ANCILLARY TESTS 597
DIFFERENTIAL DIAGNOSIS 597
DIAGNOSTIC CHECKLIST 597
SELECTED REFERENCES 597
Chapter\r122. Synovial Sarcoma 602
TERMINOLOGY 603
CLINICAL ISSUES 603
MACROSCOPIC 603
MICROSCOPIC 603
ANCILLARY TESTS 603
DIFFERENTIAL DIAGNOSIS 603
DIAGNOSTIC CHECKLIST 603
SELECTED REFERENCES 603
Chapter\r123. Malignant Solitary Fibrous Tumor (Fibrosarcoma) 608
TERMINOLOGY 609
CLINICAL ISSUES 609
MACROSCOPIC 609
MICROSCOPIC 609
ANCILLARY TESTS 609
DIFFERENTIAL DIAGNOSIS 609
DIAGNOSTIC CHECKLIST 609
SELECTED REFERENCES 609
Chapter\r124. Smooth Muscle Tumors of Pleura 614
TERMINOLOGY 615
CLINICAL ISSUES 615
IMAGING 615
MACROSCOPIC 615
MICROSCOPIC 615
ANCILLARY TESTS 615
DIFFERENTIAL DIAGNOSIS 615
DIAGNOSTIC CHECKLIST 615
GRADING 616
SELECTED REFERENCES 616
Chapter\r125. Desmoplastic Small Round Cell Tumor 620
TERMINOLOGY 621
ETIOLOGY/PATHOGENESIS 621
CLINICAL ISSUES 621
MACROSCOPIC 621
MICROSCOPIC 621
ANCILLARY TESTS 621
DIFFERENTIAL DIAGNOSIS 621
DIAGNOSTIC CHECKLIST 621
SELECTED REFERENCES 621
SECTION 3:\rOther Lesions of Pleura 625
Chapter\r126. Pleural Endometriosis 626
TERMINOLOGY 627
CLINICAL ISSUES 627
IMAGING 627
MICROSCOPIC 627
DIFFERENTIAL DIAGNOSIS 627
DIAGNOSTIC CHECKLIST 627
SELECTED REFERENCES 627
Part III: Mediastinum 631
SECTION 1:\rNeoplasms, Benign 631
Chapter\r127. Lymphangioma 632
TERMINOLOGY 633
ETIOLOGY/PATHOGENESIS 633
CLINICAL ISSUES 633
IMAGING 633
MACROSCOPIC 633
MICROSCOPIC 633
DIFFERENTIAL DIAGNOSIS 633
SELECTED REFERENCES 633
Chapter\r128. Hemangioma 636
TERMINOLOGY 637
CLINICAL ISSUES 637
IMAGING 637
MACROSCOPIC 637
MICROSCOPIC 637
DIFFERENTIAL DIAGNOSIS 637
SELECTED REFERENCES 637
Chapter\r129. Paraganglioma 640
TERMINOLOGY 641
ETIOLOGY/PATHOGENESIS 641
CLINICAL ISSUES 641
MACROSCOPIC 641
MICROSCOPIC 641
DIFFERENTIAL DIAGNOSIS 641
DIAGNOSTIC CHECKLIST 642
SELECTED REFERENCES 642
SECTION 2:\rNeoplasms, Malignant, Primary 646
Epithelial Neoplasms 648
Chapter\r130. Overview of Malignant Thymic Neoplasms 648
TERMINOLOGY 648
EPIDEMIOLOGY 648
CLINICAL IMPLICATIONS 649
MACROSCOPIC 649
SELECTED REFERENCES 649
Chapter\r131. Thymoma 650
TERMINOLOGY 651
ETIOLOGY/PATHOGENESIS 651
CLINICAL ISSUES 651
IMAGING 651
MACROSCOPIC 651
MICROSCOPIC 652
DIFFERENTIAL DIAGNOSIS 653
DIAGNOSTIC CHECKLIST 653
SELECTED REFERENCES 654
Chapter\r132. Atypical Thymoma 666
TERMINOLOGY 667
CLINICAL ISSUES 667
MACROSCOPIC 667
MICROSCOPIC 667
ANCILLARY TESTS 667
DIFFERENTIAL DIAGNOSIS 667
DIAGNOSTIC CHECKLIST 667
SELECTED REFERENCES 667
Chapter\r133. Thymic Carcinoma 676
TERMINOLOGY 677
ETIOLOGY/PATHOGENESIS 677
CLINICAL ISSUES 677
IMAGING 677
MACROSCOPIC 677
MICROSCOPIC 677
ANCILLARY TESTS 678
DIFFERENTIAL DIAGNOSIS 678
DIAGNOSTIC CHECKLIST 679
SELECTED REFERENCES 679
Chapter\r134. Neuroendocrine Carcinomas of Thymus 690
TERMINOLOGY 691
ETIOLOGY/PATHOGENESIS 691
CLINICAL ISSUES 691
MACROSCOPIC 691
MICROSCOPIC 691
DIFFERENTIAL DIAGNOSIS 691
DIAGNOSTIC CHECKLIST 691
SELECTED REFERENCES 692
Germ Cell Tumors 696
Chapter\r135. Mediastinal Teratoma 696
TERMINOLOGY 697
ETIOLOGY/PATHOGENESIS 697
CLINICAL ISSUES 697
IMAGING 697
MACROSCOPIC 697
MICROSCOPIC 697
DIFFERENTIAL DIAGNOSIS 697
DIAGNOSTIC CHECKLIST 697
SELECTED REFERENCES 698
Chapter\r136. Mediastinal Seminoma 702
TERMINOLOGY 703
ETIOLOGY/PATHOGENESIS 703
CLINICAL ISSUES 703
IMAGING 703
MACROSCOPIC 703
MICROSCOPIC 703
DIFFERENTIAL DIAGNOSIS 703
DIAGNOSTIC CHECKLIST 703
SELECTED REFERENCES 704
Chapter\r137. Yolk Sac Tumor 708
TERMINOLOGY 709
ETIOLOGY/PATHOGENESIS 709
CLINICAL ISSUES 709
IMAGING 709
MACROSCOPIC 709
MICROSCOPIC 709
ANCILLARY TESTS 709
DIFFERENTIAL DIAGNOSIS 709
DIAGNOSTIC CHECKLIST 710
SELECTED REFERENCES 710
Chapter\r138. Choriocarcinoma 714
TERMINOLOGY 715
ETIOLOGY/PATHOGENESIS 715
CLINICAL ISSUES 715
IMAGING 715
MACROSCOPIC 715
MICROSCOPIC 715
DIFFERENTIAL DIAGNOSIS 715
DIAGNOSTIC CHECKLIST 716
SELECTED REFERENCES 716
Chapter\r139. Embryonal Carcinoma 720
TERMINOLOGY 721
ETIOLOGY/PATHOGENESIS 721
CLINICAL ISSUES 721
IMAGING 721
MACROSCOPIC 721
MICROSCOPIC 721
ANCILLARY TESTS 721
DIFFERENTIAL DIAGNOSIS 721
DIAGNOSTIC CHECKLIST 722
SELECTED REFERENCES 722
Hematopoietic Malignancies 726
Chapter\r140. Hodgkin Lymphoma of Mediastinum 726
TERMINOLOGY 727
CLINICAL ISSUES 727
IMAGING 727
MACROSCOPIC 727
MICROSCOPIC 727
ANCILLARY TESTS 727
DIFFERENTIAL DIAGNOSIS 727
DIAGNOSTIC CHECKLIST 728
SELECTED REFERENCES 728
Chapter\r141. Diffuse Large Cell Lymphoma of Mediastinum 734
TERMINOLOGY 735
ETIOLOGY/PATHOGENESIS 735
CLINICAL ISSUES 735
IMAGING 735
MACROSCOPIC 735
MICROSCOPIC 735
ANCILLARY TESTS 736
DIFFERENTIAL DIAGNOSIS 736
DIAGNOSTIC CHECKLIST 736
SELECTED REFERENCES 737
Chapter\r142. Lymphoblastic Lymphoma 748
TERMINOLOGY 749
ETIOLOGY/PATHOGENESIS 749
CLINICAL ISSUES 749
IMAGING 749
MICROSCOPIC 749
ANCILLARY TESTS 749
DIFFERENTIAL DIAGNOSIS 750
DIAGNOSTIC CHECKLIST 750
SELECTED REFERENCES 750
Chapter\r143. MALT Lymphoma of Thymus 754
TERMINOLOGY 755
CLINICAL ISSUES 755
MACROSCOPIC 755
MICROSCOPIC 755
ANCILLARY TESTS 755
DIFFERENTIAL DIAGNOSIS 755
DIAGNOSTIC CHECKLIST 755
SELECTED REFERENCES 755
Mesenchymal Neoplasms 758
Chapter\r144. Liposarcoma 758
TERMINOLOGY 759
CLINICAL ISSUES 759
MACROSCOPIC 759
MICROSCOPIC 759
ANCILLARY TESTS 760
DIFFERENTIAL DIAGNOSIS 760
DIAGNOSTIC CHECKLIST 760
SELECTED REFERENCES 760
Chapter\r145. Leiomyosarcoma 768
TERMINOLOGY 769
CLINICAL ISSUES 769
IMAGING 769
MACROSCOPIC 769
MICROSCOPIC 769
ANCILLARY TESTS 769
DIFFERENTIAL DIAGNOSIS 769
DIAGNOSTIC CHECKLIST 770
SELECTED REFERENCES 770
Chapter\r146. Synovial Sarcoma 774
TERMINOLOGY 775
ETIOLOGY/PATHOGENESIS 775
CLINICAL ISSUES 775
IMAGING 775
MACROSCOPIC 775
MICROSCOPIC 775
ANCILLARY TESTS 775
DIFFERENTIAL DIAGNOSIS 776
DIAGNOSTIC CHECKLIST 776
SELECTED REFERENCES 776
Chapter\r147. Neurofibroma 786
TERMINOLOGY 787
ETIOLOGY/PATHOGENESIS 787
CLINICAL ISSUES 787
MACROSCOPIC 787
MICROSCOPIC 787
DIFFERENTIAL DIAGNOSIS 787
DIAGNOSTIC CHECKLIST 787
SELECTED REFERENCES 787
Chapter\r148. Peripheral Nerve Sheath Tumor 790
TERMINOLOGY 791
ETIOLOGY/PATHOGENESIS 791
CLINICAL ISSUES 791
IMAGING 791
MACROSCOPIC 791
MICROSCOPIC 791
ANCILLARY TESTS 791
DIFFERENTIAL DIAGNOSIS 791
DIAGNOSTIC CHECKLIST 792
SELECTED REFERENCES 792
Chapter\r149. Solitary Fibrous Tumor/Fibrosarcoma 796
TERMINOLOGY 797
CLINICAL ISSUES 797
MACROSCOPIC 797
MICROSCOPIC 797
DIFFERENTIAL DIAGNOSIS 798
DIAGNOSTIC CHECKLIST 798
SELECTED REFERENCES 798
Chapter\r150. Epithelioid Hemangioendothelioma 806
TERMINOLOGY 807
ETIOLOGY/PATHOGENESIS 807
CLINICAL ISSUES 807
IMAGING 807
MACROSCOPIC 807
MICROSCOPIC 807
ANCILLARY TESTS 807
DIFFERENTIAL DIAGNOSIS 807
DIAGNOSTIC CHECKLIST 807
SELECTED REFERENCES 808
Chapter\r151. Mesenchymal Chondrosarcoma 812
TERMINOLOGY 813
ETIOLOGY/PATHOGENESIS 813
CLINICAL ISSUES 813
IMAGING 813
MACROSCOPIC 813
MICROSCOPIC 813
ANCILLARY TESTS 813
DIFFERENTIAL DIAGNOSIS 813
DIAGNOSTIC CHECKLIST 813
SELECTED REFERENCES 813
Chapter\r152. Chordoma 816
TERMINOLOGY 817
CLINICAL ISSUES 817
IMAGING 817
MACROSCOPIC 817
MICROSCOPIC 817
ANCILLARY TESTS 817
DIFFERENTIAL DIAGNOSIS 817
SELECTED REFERENCES 817
Chapter\r153. Alveolar Soft Part Sarcoma 822
TERMINOLOGY 823
ETIOLOGY/PATHOGENESIS 823
CLINICAL ISSUES 823
IMAGING 823
MACROSCOPIC 823
MICROSCOPIC 823
DIFFERENTIAL DIAGNOSIS 823
DIAGNOSTIC CHECKLIST 823
SELECTED REFERENCES 823
Chapter\r154. Rhabdomyosarcoma 828
TERMINOLOGY 829
CLINICAL ISSUES 829
IMAGING 829
MICROSCOPIC 829
ANCILLARY TESTS 829
DIFFERENTIAL DIAGNOSIS 829
SELECTED REFERENCES 829
Sympathetic Nervous System Tumors 834
Chapter\r155. Ganglioneuroma 834
TERMINOLOGY 835
ETIOLOGY/PATHOGENESIS 835
CLINICAL ISSUES 835
MACROSCOPIC 835
MICROSCOPIC 835
DIFFERENTIAL DIAGNOSIS 835
DIAGNOSTIC CHECKLIST 835
SELECTED REFERENCES 835
Chapter\r156. Neuroblastoma/Ganglioneuroblastoma 838
TERMINOLOGY 839
ETIOLOGY/PATHOGENESIS 839
CLINICAL ISSUES 839
IMAGING 839
MACROSCOPIC 839
MICROSCOPIC 839
DIFFERENTIAL DIAGNOSIS 839
DIAGNOSTIC CHECKLIST 839
SELECTED REFERENCES 839
Chapter\r157. Ependymoma 844
TERMINOLOGY 845
ETIOLOGY/PATHOGENESIS 845
CLINICAL ISSUES 845
MACROSCOPIC 845
MICROSCOPIC 845
DIFFERENTIAL DIAGNOSIS 845
DIAGNOSTIC CHECKLIST 845
GRADING 845
SELECTED REFERENCES 845
Other Tumors 848
Chapter\r158. Ectopic Parathyroid Tumor 848
TERMINOLOGY 849
ETIOLOGY/PATHOGENESIS 849
CLINICAL ISSUES 849
IMAGING 849
MACROSCOPIC 849
MICROSCOPIC 849
DIFFERENTIAL DIAGNOSIS 849
DIAGNOSTIC CHECKLIST 849
SELECTED REFERENCES 850
Chapter\r159. Ectopic Thyroid Tumor 854
TERMINOLOGY 855
ETIOLOGY/PATHOGENESIS 855
CLINICAL ISSUES 855
IMAGING 855
MACROSCOPIC 855
MICROSCOPIC 855
DIFFERENTIAL DIAGNOSIS 855
DIAGNOSTIC CHECKLIST 855
SELECTED REFERENCES 855
SECTION 3:\rOther Benign/Reactive Conditions 859
Chapter\r160. Thymolipoma 860
TERMINOLOGY 861
ETIOLOGY/PATHOGENESIS 861
CLINICAL ISSUES 861
IMAGING 861
MACROSCOPIC 861
MICROSCOPIC 861
DIFFERENTIAL DIAGNOSIS 861
DIAGNOSTIC CHECKLIST 861
SELECTED REFERENCES 861
Chapter 161. Castleman Disease 864
TERMINOLOGY 865
ETIOLOGY/PATHOGENESIS 865
CLINICAL ISSUES 865
MICROSCOPIC 865
ANCILLARY TESTS 865
DIFFERENTIAL DIAGNOSIS 865
SELECTED REFERENCES 865
Chapter 162. Benign Mediastinal Foregut Cyst 870
TERMINOLOGY 871
ETIOLOGY/PATHOGENESIS 871
CLINICAL ISSUES 871
IMAGING 871
MACROSCOPIC 871
MICROSCOPIC 871
DIFFERENTIAL DIAGNOSIS 871
DIAGNOSTIC CHECKLIST 871
SELECTED REFERENCES 871
Chapter 163. Acquired Multilocular Thymic Cyst 876
TERMINOLOGY 877
ETIOLOGY/PATHOGENESIS 877
CLINICAL ISSUES 877
MACROSCOPIC 877
MICROSCOPIC 877
DIFFERENTIAL DIAGNOSIS 877
DIAGNOSTIC CHECKLIST 877
SELECTED REFERENCES 877
Chapter 164. Idiopathic Sclerosing Mediastinitis 884
TERMINOLOGY 885
ETIOLOGY/PATHOGENESIS 885
CLINICAL ISSUES 885
MACROSCOPIC 885
MICROSCOPIC 885
ANCILLARY TESTS 885
DIFFERENTIAL DIAGNOSIS 885
DIAGNOSTIC CHECKLIST 885
SELECTED REFERENCES 885
INDEX I-i