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The Human Body in Health & Disease - E-Book

The Human Body in Health & Disease - E-Book

Kevin T. Patton | Gary A. Thibodeau

(2017)

Additional Information

Book Details

Abstract

No one explains A&P more clearly! The Human Body in Health & Disease, 7th Edition makes it easier to understand how the body works, both in normal conditions and when things go wrong. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. New to this edition are Connect It! features with bonus online content and concept maps with flow charts to simplify complex topics. From noted educators Kevin Patton and Gary Thibodeau, this book presents A&P in a way that lets you know and understand what is important.

  • More than 545 full-color photographs and drawings bring difficult A&P concepts to life and illustrate the most current scientific knowledge. 
  • Clear, conversational writing style breaks down information into brief ‘chunks,’ making principles easier to understand.
  • UNIQUE! Clear View of the Human Body transparencies allow you to peel back the layers of the body, with a 22-page, full-color insert showing the male and female human body along several planes. 
  • Over 50 Animation Direct 3-D animations provide dynamic visual explanations for key concepts, with callouts in the text directing you to these animations on the Evolve companion website. 
  • Language of Science/Language of Medicine presents lists of medical terms, pronunciations, and word parts to help you become familiar with A&P terminology and the meanings of individual word parts. 
  • Useful learning features include study tips, chapter objectives, case studies, critical thinking questions, summary boxes, review questions, and chapter tests.
  • A study guide reinforces your understanding of anatomy and physiology with a variety of practical exercises to help you review and apply key A&P concepts. Sold separately.
  • NEW and UNIQUE! Connect It! articles on the Evolve companion website provide bonus information for you to explore, and are called out in the text.
  • NEW and UNIQUE! Active Concept Maps on Evolve utilize animated and narrated flow charts to explain complex topics, and are also called out in the text.
  • NEW! Chapter objectives and Active Learning sections more closely tie objectives to the end-of-chapter material.
  • UPDATED! Genetics chapter includes the latest and most important advances.

Table of Contents

Section Title Page Action Price
Front cover Cover
Anatomical directions ifc
Contents in brief i
Evolve learning system ii
Front matter iii
The human body in health & disease iii
Copyright iv
About the authors v
Contributor panel vi
Scientific review panel vii
Preface ix
Instructional design ix
Unifying themes ix
Organization and content ix
Illustrations and page design x
Clear view of the human body x
Embedded learning tools x
Hints: x
Chapter outline: x
Chapter objectives: x
Language of science and medicine: x
Quick check questions: xi
Active concept maps: xi
Boxed sidebars: xi
Connect it! online articles: xi
AnimationDirect: xi
Outline summaries: xi
Audio chapter summary boxes: xi
Active learning tools: xi
Glossary: xii
Index: xii
Digital learning tools xii
Online resources for instructors xii
TEACH instructor resource manual xii
Test bank xii
Image collection xii
Update guide xiii
Supplements xiii
Summary of changes to the seventh edition xiii
A word of thanks xiv
How to use this book xv
1. Get your head into it xv
2. Gain familiarity xv
3. Seek mastery xv
Table of contents xvii
CHAPTER 1 Introduction to the body 2
Language of science 3
Language of medicine 19
Scientific method 4
Levels of organization 4
Anatomical position 7
Anatomical directions 7
Directional terms 7
Anatomical compass rosette 8
Planes of the body 8
Body cavities 9
Dorsal cavities 9
Ventral cavities 9
Thoracic and abdominopelvic cavities 9
Abdominopelvic quadrants and regions 9
Abdominopelvic quadrants 9
Abdominopelvic regions 10
Body regions 11
Balance of body functions 14
Homeostasis 14
Feedback control 14
Negative feedback 15
Positive feedback 15
Normal fluctuations 16
❑ Outline summary 19
❑ Active learning 21
Table of contents i
CHAPTER 2 Chemistry of life 24
Language of science 25
Language of medicine 38
Levels of chemical organization 25
Atoms 25
Elements, molecules, and compounds 26
Chemical bonding 27
Ionic bonds 27
Covalent bonds 27
Hydrogen bonds 28
Inorganic chemistry 29
Water 29
Solutions 29
Water chemistry 29
Acids, bases, and salts 30
Acids 30
Bases 30
pH 30
Salts 31
Homeostasis of pH 31
Organic chemistry 31
Carbohydrates 31
Lipids 32
Triglycerides 32
Phospholipids 32
Steroids 33
Proteins 33
Nucleic acids 35
Clinical applications of chemistry 36
❑ Outline summary 38
❑ Active learning 40
CHAPTER 3 Cells 42
Language of science 43
Language of medicine 64
Overview of cells 43
Size and shape 43
Composition 44
Parts of the cell 44
Plasma membrane 44
Cytoplasm 45
Ribosomes 47
Endoplasmic reticulum 47
Golgi apparatus 47
Mitochondria 47
Lysosomes 47
Centrosome 48
Cell extensions 48
Microvilli 48
Cilia 49
Flagella 49
Nucleus 49
Central structure of a cell 49
Nucleolus 50
Chromatin and chromosomes 50
Relationship of cell structure and function 50
Movement of substances through cell membranes 50
Types of membrane transport 50
Passive transport processes 51
Diffusion 51
Osmosis 52
Dialysis 52
Filtration 53
Active transport processes 53
Ion pumps 54
Phagocytosis 54
Pinocytosis 55
Cell transport and disease 55
Cell growth and reproduction 56
Cell growth 56
DNA 56
RNA 57
Protein synthesis 57
Transcription  57
Translation 57
Protein synthesis and disease 58
Cell reproduction 59
Cell life cycle 59
DNA replication 59
Mitosis 59
Prophase 59
Metaphase 59
Anaphase 60
Telophase 60
Results of cell division 60
Changes in cell growth and reproduction 60
❑ Outline summary 64
❑ Active learning 67
CHAPTER 4 Tissues 70
Language of science 71
Language of medicine 86
Introduction to tissues 71
Tissue types 71
Matrix 72
Epithelial tissue 72
Introduction to epithelial tissues 72
Overview 72
Shape of cells 73
Arrangement of cells 73
Squamous epithelium 73
Simple squamous epithelium 73
Stratified squamous epithelium 73
Cuboidal epithelium 75
Simple columnar epithelium 75
Pseudostratified epithelium 76
Transitional epithelium 76
Connective tissue 76
Introduction to connective tissue 76
Overview 76
Cells and matrix 78
Types of connective tissue 78
Fibrous connective tissue 78
Loose fibrous connective tissue (areolar) 78
Adipose tissue 78
Reticular tissue 78
Dense fibrous connective tissue 79
Bone 80
Cartilage 80
Overview 80
Hyaline cartilage 80
Fibrocartilage 80
Elastic cartilage 80
Blood tissue 80
Hematopoietic tissue 81
Muscle tissue 81
Introduction to muscle tissue 81
Skeletal muscle tissue 81
Cardiac muscle tissue 82
Smooth muscle tissue 82
Nervous tissue 83
Tissue repair 83
❑ Outline summary 86
❑ Active learning 88
CHAPTER 5 Organ systems 92
Language of science 93
Language of medicine 107
Organ systems of the body 93
Integumentary system 93
Skeletal system 94
Muscular system 94
Skeletal muscles 94
Muscles of other systems 95
Nervous system 95
Endocrine system 96
Cardiovascular system 96
Lymphatic and immune systems 97
Lymphatic system 97
Immune system 97
Respiratory system 98
Digestive system 98
Urinary system 99
Reproductive systems 99
Human reproduction 99
Male reproductive system 100
Female reproductive system 100
Body as a whole 101
Homeostasis 101
Applying organ system concepts 101
Organ replacement 101
Vital and nonvital organs 101
Artificial organs 101
Nonvital organ replacement 101
Vital organ replacement 103
Medical machines 103
Engineered tissues and organs 104
Organ transplantation 104
Surgical transplants 104
Immune rejection of transplants 104
❑ Outline summary 108
❑ Active learning 110
CHAPTER 6 Mechanisms of disease 112
Language of science 113
Language of medicine 137
Studying disease 113
Disease terminology 113
Signs, symptoms, and disease 113
Disease progression 114
Patterns of disease 114
Introduction to epidemiology 114
Tracking disease 114
Stopping the spread of disease 115
Pathophysiology 115
Mechanisms of disease 115
Disturbances of homeostasis 115
Types of disease mechanisms 116
Genetic mechanisms 116
Infectious mechanisms 116
Neoplastic mechanisms 116
Traumatic mechanisms 116
Metabolic mechanisms 116
Inflammatory mechanisms 116
Degeneration 116
Risk factors 117
Types of risk factors 117
Genetic factors 117
Age 117
Lifestyle 117
Stress 117
Environmental factors 117
Preexisting conditions 117
Combined risk factors 117
Avoiding risk of disease 117
Pathogenic organisms and particles 117
Viruses 118
Introduction to viruses 118
Examples of viruses 118
Human immunodeficiency virus 118
Coronaviruses 119
Flaviviruses 119
Prions 120
Bacteria 120
Fungi 123
Protozoa 123
Pathogenic animals 124
Prevention and control 125
Mechanisms of transmission 125
Person-to-person contact 125
Environmental contact 125
Opportunistic invasion 125
Transmission by a vector 126
Prevention and treatment strategies 126
Vaccination 126
Drug therapy 127
Antibiotic drugs 127
Antiviral drugs 128
Tumors and cancer 128
Neoplasms 128
Benign and malignant tumors 128
Types of tumors 129
Causes of cancer 130
Abnormal cell division 130
Genetic factors 130
Carcinogens 130
Age 130
Environment 130
Viruses 131
Pathogenesis of cancer 131
Detecting cancer 131
Self-examination 131
Diagnostic imaging 131
Biopsy 132
Blood test 132
Stages and grades of cancer 133
Cancer treatment 133
Inflammation 134
Inflammatory response 134
Introduction to inflammation 134
Mechanisms of inflammation 134
Inflammatory disease 135
Local and systemic inflammation 135
Fever 135
Acute and chronic inflammation 136
❑ Outline summary 139
❑ Active learning 141
CHAPTER 7 Skin and membranes 144
Language of science 145
Language of medicine 167
Body membranes 145
Classification of membranes 145
Epithelial membranes 146
Types of epithelial membrane 146
Cutaneous membrane 146
Serous membranes 146
Mucous membranes 147
Connective tissue membranes 147
Skin structure 148
Overview of skin structure 148
Epidermis 149
Epidermal structure 149
Skin pigment 149
Melanin 149
Skin color changes 149
Dermal-epidermal junction 150
Dermis 150
Overview of dermis 150
Papillary layer 150
Dermal papillae 150
Dermal ridges 150
Reticular layer 151
Fibrous network 151
Birthmarks 151
Subcutaneous tissue 151
Hair, nails, and skin receptors 151
Hair 151
Location of hair 151
Hair growth 152
Hair loss 152
Arrector pili muscle 153
Nails 153
Nail growth and structure 153
Variations in nail structure 153
Skin receptors 154
Skin glands 154
Sweat glands 154
Eccrine glands 154
Apocrine glands 154
Sebaceous glands 154
Sebum 154
Acne 155
Functions of the skin 155
Protection 155
Temperature regulation 155
Sensation 156
Excretion 156
Synthesis of vitamin D 156
Disorders of the skin 156
Skin lesions 156
Burns 157
Severity of burns 157
Depth classification of burns 157
First-degree burns 157
Second-degree burns 157
Third-degree burns 160
Fourth-degree burns 160
Estimating body surface area 161
Skin infections 161
Impetigo 161
Tinea 161
Warts 161
Boils 161
Scabies 161
Vascular and inflammatory skin disorders 161
Decubitus ulcers 161
Hives 162
Scleroderma 162
Psoriasis 162
Eczema 162
Skin cancer 163
Role of ultraviolet radiation 163
Squamous cell carcinoma 164
Basal cell carcinoma 164
Melanoma 164
Kaposi sarcoma 165
❑ Outline summary 168
❑ Active learning 171
CHAPTER 8 Skeletal system 174
Language of science 175
Language of medicine 211
Functions of the skeletal system 175
Support 175
Protection 176
Movement 176
Storage 176
Hematopoiesis 176
Gross structure of bones 176
Types of bones 176
Structure of long bones 176
Structure of flat bones 177
Microscopic structure of bones 177
Bone tissue structure 177
Cancellous bone (spongy bone) 177
Compact bone 177
Cartilage tissue structure 177
Bone development 177
Making and remodeling bone 177
Endochondral ossification 179
Intramembranous ossification 179
Axial skeleton 180
Skull 181
Regions of the skull 181
Sinuses 181
Sutures and fontanels 185
Hyoid bone 185
Vertebral column (spine) 186
Vertebrae 186
Sacrum and coccyx 186
Spinal curvatures 187
Convex and concave curvatures 187
Abnormal spinal curvatures 188
Thorax 189
Appendicular skeleton 190
Upper extremity 190
Lower extremity 191
Skeletal variations 194
Male-female skeletal differences 194
Age differences 195
Environmental factors 195
Joints 196
Articulation of bones 196
Kinds of joints 196
Synarthroses 196
Amphiarthroses 196
Diarthroses 197
Structure of diarthroses 197
Function of diarthroses 198
Ball-and-socket joints 198
Hinge joints 198
Pivot joints 199
Saddle joints 199
Gliding joints 199
Condyloid joints 199
Skeletal disorders 200
Tumors 200
Bone tumors 200
Cartilage tumors 200
Metabolic bone diseases 201
Osteoporosis 201
Rickets and osteomalacia 201
Paget disease 202
Osteogenesis imperfecta 202
Bone infection 202
Bone fractures 203
Joint disorders 204
Noninflammatory joint disease 204
Inflammatory joint disease (arthritis) 205
Rheumatoid arthritis 205
Gouty arthritis 206
Infectious arthritis 207
❑ Outline summary 212
❑ Active learning 215
CHAPTER 9 Muscular system 218
Language of science 219
Language of medicine 239
Muscle tissue 220
Skeletal muscle 220
Cardiac muscle 220
Smooth muscle 220
Structure of skeletal muscle 220
Muscle organs 220
Muscle fibers 221
Structure of muscle fibers 221
Contraction of muscle fibers 222
Function of skeletal muscle 222
Movement 223
Posture 224
Heat production 224
Fatigue 224
Integration with other body systems 225
Motor unit 225
Muscle stimulus 225
Types of muscle contraction 225
Twitch and tetanic contractions 225
Isotonic contraction 226
Isometric contraction 226
Effects of exercise 226
Movements produced by muscles 228
Angular movements 228
Circular movements 228
Special movements 229
Skeletal muscle groups 230
Muscles of the head and neck 232
Muscles of the upper extremities 232
Muscles of the trunk 233
Muscles of the lower extremities 234
Muscular disorders 235
Muscle injury 235
Muscle infections 235
Muscular dystrophy 236
Myasthenia gravis 237
❑ Outline summary 240
❑ Active learning 244
CHAPTER 10 Nervous system 248
Language of science 249
Language of medicine 282
Organs and divisions of the nervous system 249
Cells of the nervous system 250
Neurons 250
Neuron structure 250
Types of neurons 250
Sensory neurons 250
Motor neurons 250
Interneurons 250
Glia 250
Function of glia 250
Central glia 250
Peripheral glia 252
Disorders of nervous tissue 252
Multiple sclerosis 252
Tumors 253
Nerves and tracts 253
Nerve signals 253
Reflex arcs 253
Neuron pathways 253
Structure of reflex arcs 254
Reflex responses 254
Nerve impulses 255
Definition of a nerve impulse 255
Mechanism of a nerve impulse 255
Conduction of nerve impulses 256
Synapses 256
Structure and function of a synapse 256
Neurotransmitters and receptors 257
Neurotransmitters 257
Receptors 258
Parkinson disease 259
Central nervous system 259
Brain 260
Divisions of the brain 260
Brainstem 260
Cerebellum 260
Structure 260
Function 260
Diencephalon 261
Hypothalamus 261
Thalamus 262
Pineal gland 262
Cerebrum 262
Structure of the cerebrum 262
Function of the cerebrum 262
Brain disorders 264
Destruction of brain tissue 264
Physical injury 264
Stroke 264
Cerebral palsy 264
Degenerative disease 265
Seizure disorders 266
Spinal cord 266
Structure 266
Functions 268
Coverings and fluid spaces 268
Meninges and bone 268
Cerebrospinal fluid spaces 269
Peripheral nervous system 270
Cranial nerves 270
Spinal nerves 270
Structure 270
Functions 273
Peripheral nerve disorders 273
Autonomic nervous system 274
Overview 274
Functional anatomy 275
Autonomic conduction paths 276
Sympathetic division 276
Structure 276
CHAPTER 11 Senses 290
Language of science 291
Language of medicine 311
Classification of senses 291
General senses 291
Special senses 292
Sensory receptor types 292
Sensory pathways 293
General senses 293
Distribution of general sense receptors 293
Modes of sensation 293
Disorders involving general senses 294
Special senses 294
Vision 294
Structure and function of the eye 295
Fibrous layer 295
Vascular layer 295
Inner layer 296
Fluids of the eyeball 296
Visual pathway 297
Disorders of vision 297
Refraction disorders 297
Common focusing problems 297
Cataracts 300
Conjunctivitis 300
Strabismus 300
Disorders of the retina 301
Retinal detachment 301
Diabetic retinopathy 301
Glaucoma 301
Retinal degeneration 301
Color blindness 302
Disorders of the visual pathway 302
Hearing and equilibrium 302
Ear 302
External ear 302
Middle ear 304
Inner ear 304
Hearing 304
Equilibrium 306
Hearing and equilibrium disorders 307
Hearing disorders 307
Equilibrium disorders 307
Taste 307
Smell 308
Integration of senses 309
❑ Outline summary 312
❑ Active learning 315
CHAPTER 12 Endocrine system 318
Language of science 319
Language of medicine 341
Endocrine glands 320
Mechanisms of hormone action 320
Nonsteroid hormones 320
Steroid hormones 321
Regulation of hormone secretion 324
Negative feedback 324
Positive feedback 324
Levels of regulation 324
Mechanisms of endocrine disease 325
Prostaglandins 325
Pituitary gland 326
Structure of the pituitary gland 326
Anterior pituitary gland hormones 326
Thyroid-stimulating hormone 326
Adrenocorticotropic hormone 326
Follicle-stimulating hormone 326
Luteinizing hormone 326
Growth hormone 326
Prolactin 327
Posterior pituitary gland hormones 328
Antidiuretic hormone 328
Oxytocin 328
Hypothalamus 328
Thyroid gland 329
Thyroid hormone 329
Calcitonin 330
Parathyroid glands 331
Adrenal glands 331
Location of adrenal glands 331
Adrenal cortex 331
Zones of adrenal cortex 332
Aldosterone 332
Cortisol 332
Adrenal sex hormones 333
Adrenal medulla 333
Adrenal abnormalities 334
Pancreatic islets 334
Sex glands 336
Female sex glands 336
Male sex glands 336
Thymus 337
Placenta 337
Pineal gland 338
Endocrine functions throughout the body 338
Other endocrine structures 338
Hormone actions in every organ 339
❑ Outline summary 342
❑ Active learning 345
CHAPTER 13 Blood 348
Language of science 349
Language of medicine 369
Blood composition 349
Blood tissue 349
Blood plasma 350
Formed elements 351
Hematopoiesis 352
Mechanisms of blood disease 352
Red blood cells 352
RBC structure and function 352
RBC count 353
Hemoglobin 354
RBC abnormalities 354
Blood types 355
Systems of blood typing 355
ABO system 355
Rh system 356
Combined ABO-Rh system 357
Red blood cell disorders 358
Polycythemia 358
Anemia 358
Hemorrhagic anemia 358
Aplastic anemia 359
Deficiency anemias 359
Reduction of normal hemoglobin 359
Pernicious anemia 359
Folate deficiency anemia 359
Iron deficiency anemia 359
Hemolytic anemias 360
RBC destruction 360
Sickle cell anemia 360
Thalassemia 360
Hemolytic disease of the newborn 361
White blood cells 361
Introduction to WBCs 361
WBC count 362
WBC types 362
Granular leukocytes 362
Agranular leukocytes 362
White blood cell disorders 363
Multiple myeloma 363
Leukemia 363
Chronic lymphocytic leukemia 363
Acute lymphocytic leukemia 363
Chronic myeloid leukemia 364
Acute myeloid leukemia 364
Infectious mononucleosis 364
Platelets and blood clotting 365
Platelets 365
Blood clotting 365
Clotting disorders 365
Abnormal blood clots 365
Types of abnormal clots 365
Anticoagulant therapy 365
Hemophilia 366
Thrombocytopenia 368
Vitamin K deficiency 368
❑ Outline summary 371
❑ Active learning 375
CHAPTER 14 Heart 378
Language of science 379
Language of medicine 396
Location of the heart 379
Functional anatomy of the heart 380
Heart chambers 380
Pericardium 381
Coverings of the heart 381
Pericarditis 381
Heart action 383
Heart valves 383
Valve structure and function 383
Valve disorders 383
Heart sounds 384
Blood flow through the heart 384
Blood supply to heart muscle 385
Cardiac cycle 387
Electrical activity of the heart 388
Conduction system 388
Electrocardiography 388
Cardiac dysrhythmia 389
Heart block 389
Bradycardia 390
Tachycardia 390
Sinus dysrhythmia 390
Premature contractions 390
Fibrillation 390
Cardiac output 392
Definition of cardiac output 392
Heart rate 393
Stroke volume 393
Heart failure 394
❑ Outline summary 397
❑ Active learning 400
CHAPTER 15 Circulation of blood 402
Language of science 403
Language of medicine 422
Blood vessels 403
Types 403
Structure 404
Outer layer 404
Middle layer 404
Inner layer 404
Functions 405
Arteries and arterioles 405
Capillary exchange 405
Veins and venules 406
Disorders of blood vessels 406
Disorders of arteries 406
Arteriosclerosis 406
Aneurysm 406
Disorders of veins 408
Varicose veins 408
Phlebitis 408
Routes of circulation 408
Systemic and pulmonary circulation 408
Hepatic portal circulation 409
Fetal circulation 412
Hemodynamics 414
Defining blood pressure 414
Factors that influence blood pressure 414
Blood volume 414
Strength of heart contractions 415
Heart rate 415
Blood viscosity 416
Resistance to blood flow 416
Fluctuations in arterial blood pressure 417
Central venous blood pressure 418
Pulse 419
Hypertension 419
Definition 419
Risk factors 420
Circulatory shock 421
Cardiogenic shock 421
Hypovolemic shock 421
Neurogenic shock 421
Anaphylactic shock 421
Septic shock 421
❑ Outline summary 423
❑ Active learning 425
CHAPTER 16 Lymphatic system and immunity 428
Language of science 429
Language of medicine 450
Lymphatic system 429
Organization of the lymphatic system 429
Lymph 430
Lymphatic vessels 431
Lymphedema 432
Lymphoid organs 432
Lymph nodes 433
Location 433
Biological filtration 433
Thymus 434
Tonsils 435
Spleen 435
Lymphoma 435
Immune system 436
Function of the immune system 436
Innate immunity 436
Overview 436
Inflammatory response 436
Adaptive immunity 437
Overview 437
Types of adaptive immunity 438
Immune system molecules 438
Cytokines 438
Antibodies 439
Definition 439
Functions 439
Complement proteins 440
Immune system cells 440
Phagocytes 440
Lymphocytes 441
Natural killer cells 442
B cells 442
Development of B cells 442
Function of B cells 443
T cells 443
Development of T cells 443
Functions of T cells 443
Hypersensitivity of the immune system 444
Allergy 445
Autoimmunity 445
Alloimmunity 446
Immune system deficiency 447
Congenital immune deficiency 447
Acquired immune deficiency 448
❑ Outline summary 451
❑ Active learning 454
CHAPTER 17 Respiratory system 458
Language of science 459
Language of medicine 483
Structural plan 460
Overview 460
Respiratory tract 460
Respiratory mucosa 461
Structure 461
Function 461
Upper respiratory tract 462
Nose 462
Pharynx 462
Larynx 464
Disorders of the upper respiratory tract 464
Upper respiratory infection 464
Anatomical disorders 465
Lower respiratory tract 466
Trachea 466
Bronchial tree 466
Alveoli 467
Respiratory distress 468
Infant respiratory distress 468
Adult respiratory distress 469
Lungs 469
Pleurae 469
Disorders of the lower respiratory tract 470
Lower respiratory infection 470
Restrictive pulmonary disorders 471
Obstructive pulmonary disorders 471
Lung cancer 473
Respiration 473
Pulmonary ventilation 473
Mechanics of breathing 473
Inspiration 473
Expiration 474
Pulmonary volumes 474
Regulation of ventilation 475
Homeostasis of blood gases 475
Brainstem control of respiration 475
Cerebral cortex control of respiration 476
Respiratory reflexes 476
Chemoreflexes 476
Pulmonary stretch reflexes 477
Breathing patterns 477
Gas exchange and transport 478
Pulmonary gas exchange 478
Systemic gas exchange 480
Blood transportation of gases 480
Transport of oxygen 481
Transport of carbon dioxide 481
Carbon dioxide 481
Carbaminohemoglobin 481
Bicarbonate 481
❑ Outline summary 485
❑ Active learning 488
CHAPTER 18 Digestive system 492
Language of science 493
Language of medicine 523
Overview of digestion 494
Wall of the digestive tract 495
Mouth 496
Structure of the oral cavity 496
Teeth 497
Types of teeth 497
Typical tooth 498
Salivary glands 498
Disorders of the mouth 499
Cancer 499
Dental conditions 500
Infection 501
Congenital defects 501
Pharynx 501
Structure 501
Function 502
Esophagus 502
Structure and function 502
Reflux 503
Hiatal hernia 503
Stomach 504
Structure 504
Function 505
Disorders of the stomach 505
Signs and symptoms 505
Pyloric conditions 505
Gastric ulcer 505
Stomach cancer 506
Small intestine 506
Structure 506
Function 508
Disorders of the small intestine 508
Liver and gallbladder 509
Structure 509
Function 509
Disorders of the liver and gallbladder 509
Gallstones and jaundice 509
Hepatitis 510
Cirrhosis 511
Pancreas 511
Structure and function 511
Disorders of the pancreas 511
Large intestine 512
Structure 512
Function 513
Disorders of the large intestine 514
Motility disorders 514
Inflammatory conditions 514
Colorectal cancer 515
Appendix 515
Structure and function 515
Appendicitis 516
Peritoneum 516
Location 516
Extensions 516
Peritonitis 517
Ascites 517
Digestion 517
Overview of digestions 517
Enzymes and chemical digestion 517
Carbohydrate digestion 518
Protein digestion 518
Lipid digestion 519
End products of digestion 519
Absorption 519
Mechanisms of absorption 519
Surface area and absorption 520
❑ Outline summary 525
❑ Active learning 529
CHAPTER 19 Nutrition and metabolism 532
Language of science 533
Language of medicine 547
Metabolic function of the liver 534
Macronutrients 534
Dietary sources of nutrients 534
Carbohydrate metabolism 535
Glucose catabolism 535
ATP 535
Anabolism 536
Regulation of carbohydrate metabolism 536
Fat metabolism 537
Protein metabolism 538
Micronutrients 538
Vitamins 538
Overview of vitamins 538
Vitamin imbalances 539
Minerals 540
Regulating food intake 541
Metabolic rates 541
Metabolic and eating disorders 542
Metabolic imbalances 542
Eating disorders 543
Anorexia nervosa 543
Bulimia 543
Obesity 543
Protein-calorie malnutrition 543
Body temperature 544
Thermoregulation 544
Abnormal body temperature 545
Fever 545
Malignant hyperthermia 545
Heat exhaustion 546
Heatstroke 546
Hypothermia 546
Frostbite 546
❑ Outline summary 548
❑ Active learning 550
CHAPTER 20 Urinary system 554
Language of science 555
Language of medicine 575
Kidneys 556
Location of the kidneys 556
Gross structure of the kidney 556
External anatomy 556
Internal anatomy 557
Microscopic structure of the kidney 557
Overview of kidney function 559
Formation of urine 560
Filtration 560
Reabsorption 561
Secretion 562
Summary of urine formation 562
Control of urine volume 563
Antidiuretic hormone 563
Aldosterone 563
Atrial natriuretic hormone 563
Abnormalities of urine volume 563
Elimination of urine 564
Ureters 564
Urinary bladder 565
Urethra 565
Micturition 565
Abnormalities of urine output 566
Urinalysis 567
Renal and urinary disorders 567
Obstructive disorders 567
Renal calculi 567
Tumors 567
Urinary tract infections 569
Urethritis 569
Cystitis 569
Pyelonephritis 570
Glomerular disorders 570
Nephrotic syndrome 570
Acute glomerulonephritis 570
Chronic glomerulonephritis 571
Kidney failure 571
Acute renal failure 571
Chronic renal failure 572
❑ Outline summary 576
❑ Active learning 578
CHAPTER 21 Fluid and electrolyte balance 582
Language of science 583
Language of medicine 594
Body fluid volumes 584
Body fluid compartments 584
Extracellular fluid 585
Intracellular fluid 585
Mechanisms that maintain fluid balance 585
Overview of fluid balance 585
Regulation of fluid output 586
Routes of fluid output 586
ADH mechanism 587
Aldosterone mechanism 587
ANH mechanism 587
Regulation of fluid intake 587
Exchange of fluids by blood 588
Fluid imbalances 588
Dehydration 588
Overhydration 589
Importance of electrolytes in body fluids 589
Electrolytes and nonelectrolytes 589
Ions 589
Electrolyte functions 589
Electrolyte imbalances 591
Homeostasis of electrolytes 591
Sodium imbalance 592
Potassium imbalance 592
Calcium imbalance 592
❑ Outline summary 595
❑ Active learning 597
CHAPTER 22 Acid-base balance 600
Language of science 601
Language of medicine 611
pH of body fluids 601
Using the pH scale 601
The pH unit 602
Mechanisms that control pH of body fluids 602
Overview of pH control mechanisms 602
Integration of pH control 603
Buffers 603
Respiratory mechanism of pH control 606
Urinary mechanism of pH control 606
pH imbalances 607
Acidosis and alkalosis 607
Metabolic and respiratory disturbances 607
Compensation for pH imbalances 609
❑ Outline summary 611
❑ Active learning 613
CHAPTER 23 Reproductive systems 616
Language of science 617
Language of medicine 643
Sexual reproduction 617
Producing offspring 617
Male and female systems 618
Male reproductive system 618
Structural plan 618
Reproductive tract 618
Essential organs 618
Accessory organs 618
Testes 619
Structure and location 619
Testis functions 619
Spermatogenesis 619
Sperm 620
Production of testosterone 621
Reproductive ducts 622
Overview 622
Epididymis 622
Vas deferens 622
Ejaculatory duct and urethra 623
Accessory glands 623
Seminal vesicles 623
Prostate gland 623
Bulbourethral glands 623
External genitals 623
Disorders of the male reproductive system 624
Infertility and sterility 624
Disorders of the testes 625
Reduced sperm production 625
Cryptorchidism 625
Testicular cancer 625
Disorders of the prostate 625
Benign prostatic hypertrophy 625
Prostate cancer 625
Disorders of the penis and scrotum 625
Penis disorders 625
Infection, cancer, and structural disorders 625
Erectile dysfunction 626
Scrotum disorders 626
Female reproductive system 627
Structural plan 627
Essential organs 627
Accessory organs 627
Ovaries 627
Structure and location 627
Ovary functions 628
Oogenesis 628
Production of estrogen and progesterone 629
Reproductive ducts 630
Overview 630
Uterine tubes 630
Uterus 630
Vagina 631
Accessory glands 631
Vestibular glands 631
Breasts 631
External genitals 632
Menstrual cycle 633
Overview 633
Phases 634
Ovulation 634
Control of the menstrual cycle 635
Disorders of the female reproductive system 635
Hormonal and menstrual disorders 635
Dysmenorrhea 635
Amenorrhea 635
Dysfunctional uterine bleeding 635
Premenstrual syndrome 636
Infection and inflammation 636
Infections 636
Pelvic inflammatory disease 636
Vaginitis 637
Tumors and related conditions 637
Benign uterine tumors 637
Ovarian cysts 637
Endometriosis 637
Cancer 637
Breast cancer 637
Ovarian cancer 638
Uterine cancer 638
Infertility 638
Summary of male and female reproductive systems 639
Sexually transmitted diseases 639
❑ Outline summary 644
❑ Active learning 648
CHAPTER 24 Growth, development, and aging 652
Language of science 653
Language of medicine 671
Prenatal period 654
Fertilization to implantation 654
Amniotic cavity and placenta 654
Periods of development 656
Formation of the primary germ layers 657
Histogenesis and organogenesis 658
Birth 658
Parturition 658
Stages of labor 661
Multiple births 661
Disorders of pregnancy 662
Implantation disorders 662
Preeclampsia 662
Gestational diabetes 662
Fetal death 662
Birth defects 663
Postpartum disorders 663
Postnatal period 664
Growth, development, and aging 664
Infancy 665
Childhood 666
Adolescence 666
Adulthood 666
Older adulthood 667
Aging 667
Mechanisms of aging 667
Effects of aging 668
Skin 668
Skeletal system 668
Central nervous system 669
Special senses 669
Cardiovascular system 669
Respiratory system 669
Urinary system 670
Reproductive systems 670
❑ Outline summary 672
❑ Active learning 675
CHAPTER 25 Genetics and genetic diseases 678
Language of science 679
Language of medicine 695
Genetics and human disease 679
Chromosomes and genes 680
Mechanisms of gene function 680
Human genome 680
Distribution of chromosomes to offspring 681
Gene expression 682
Hereditary traits 682
Gene pairs 682
Dominance and recessiveness 682
Codominance 683
Sex-linked traits 683
Genetic mutations 684
Genetic diseases 684
Mechanisms of genetic disease 684
Role of genes in disease 684
Single-gene mechanisms 685
Epigenetics 685
Chromosomal mechanisms 685
Single-gene diseases 686
Cystic fibrosis 686
Phenylketonuria 686
Tay-Sachs disease 688
Epigenetic conditions 688
Chromosomal diseases 688
Trisomy 21 688
XXY 689
XO 689
Prevention and treatment of genetic diseases 689
Genetic counseling 689
Pedigree 690
Punnett square 690
Karyotype 690
Treating genetic diseases 692
Treating symptoms 692
Gene therapy 692
Gene replacement 692
Gene augmentation 692
RNA interference 693
Potential of gene therapy 693
❑ Outline summary 696
❑ Active learning 697
APPENDIX A Examples of pathological conditions e
APPENDIX B Medical terminology e
Hints for learning and using medical terms e
APPENDIX C Clinical and laboratory values e
Conversion factors to international system of units (SI units) e
Glossary 701
A 701
B 705
C 707
D 713
E 715
F 718
G 719
H 721
I 724
J 726
K 726
L 726
M 728
N 731
O 733
P 734
Q 739
R 739
S 741
T 746
U 748
V 749
W 750
X 750
Y 750
Z 750
Illustration/photo credits C-
Chapter 1 C-
Chapter 2 C-
Chapter 3 C-
Chapter 4 C-
Chapter 5 C-
Chapter 6 C-
Chapter 7 C-
Chapter 8 C-
Chapter 9 C-
Chapter 10 C-
Chapter 11 C-
Chapter 12 C-
Chapter 13 C-
Chapter 14 C-
Chapter 15 C-
Chapter 16 C-
Chapter 17 C-
Chapter 18 C-
Chapter 19 C-
Chapter 20 C-
Chapter 21 C-
Chapter 22 C-
Chapter 23 C-
Chapter 24 C-
Chapter 25 C-
Index I-
A I-
B I-
C I-
D I-
E I-
F I-
G I-
H I-
I I-
J I-
K I-
L I-
M I-
N I-
O I-
P I-
Q I-
R I-
S I-
T I-
U I-
V I-
W I-
X I-
Y I-
Z I-
Clear view of the human body 1
Introduction 1
Hints for using the clear view of the body 1
Key 2
Tips and shortcuts for surviving and succeeding in A&P ibc