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Book Details
Abstract
Amino Acids, Peptides and Proteins comprises a comprehensive and critical review of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas for example discovery and validation of novel protein/peptide biomarkers, proteins and peptides for the diagnosis and therapy of a parasite infection and surface and interface analysis of functional proteins and peptides. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference to developments now and looking to the future.
Max obtained his PhD from Lomonosov Moscow State University and Russian Academy of Sciences in 2000. After a postdoctorate in Sussex, he pursued independent academic research in Bristol and Leicester before joining NPL as a principal research scientist in 2010 where he is currently a science area leader for Biotechnology.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Contents | vii | ||
| Preface | v | ||
| Peptide-derived mid-sized anti-HIV agents | 1 | ||
| 1 Introduction | 1 | ||
| 2 HIV vaccines based on an N36 derivative | 3 | ||
| 3 HIV fusion inhibitors based on an C34 derivative | 4 | ||
| 4 Chemokine receptor CXCR4 antagonists | 8 | ||
| 5 Chemokine receptor CCR5 antagonists | 12 | ||
| 6 HIV integrase inhibitors | 15 | ||
| 7 HIV entry inhibitors based on CD4 mimics | 18 | ||
| 8 Summary and future perspectives | 19 | ||
| Abbreviations | 21 | ||
| Acknowledgments | 22 | ||
| References | 23 | ||
| The discovery and validation of novel protein and peptide biomarkers | 30 | ||
| 1 Introduction | 30 | ||
| 2 The biomarker discovery phase | 31 | ||
| 3 The biomarker validation phase | 39 | ||
| 4 In silico analysis | 41 | ||
| 5 The omics pipeline | 42 | ||
| 6 Personalised medicine | 42 | ||
| 7 Biomarker exemplars | 43 | ||
| 8 The big data problem | 46 | ||
| 9 Conclusions | 47 | ||
| Abbreviations | 47 | ||
| References | 48 | ||
| Site-selective peptide and protein labelling & crosslinking | 53 | ||
| 1 Introduction | 53 | ||
| 2 Site-selective labelling of peptides and proteins | 57 | ||
| 3 Site-selective crosslinking of proteins to peptides and proteins | 70 | ||
| 4 Conclusions | 88 | ||
| Abbreviations | 89 | ||
| Acknowledgments | 91 | ||
| References | 91 | ||
| Metal complexes of amino acids and peptides | 100 | ||
| 1 Introduction | 100 | ||
| 2 Amino acid complexes | 101 | ||
| 3 Peptide complexes | 119 | ||
| 4 Future perspectives | 136 | ||
| Abbreviations | 137 | ||
| Acknowledgments | 138 | ||
| References | 138 | ||
| Mechanism of drug transport by ABC multidrug proteins in structural perspectives | 152 | ||
| 1 Introduction | 152 | ||
| 2 Structure of ABC transporters | 157 | ||
| 3 Models for the transport mechanism of ABC exporters | 164 | ||
| 4 In silico studies on the structure and mechanism of ABCB exporters | 169 | ||
| 5 Rescuing misfolding and functionally impaired variants of disease associated ABC proteins | 177 | ||
| 6 Conclusion | 178 | ||
| Abbreviations | 179 | ||
| Acknowledgments | 179 | ||
| References | 180 | ||
| Biophysical modulation of peptide–membrane interactions | 188 | ||
| 1 Introduction | 188 | ||
| 2 Current trends | 189 | ||
| 3 Case studies of biologically relevant peptide-membrane interactions | 201 | ||
| 4 Future perspectives | 216 | ||
| References | 217 | ||
| Surface and interface analysis of functional proteins and peptides | 225 | ||
| 1 Introduction | 225 | ||
| 2 Analytical techniques | 226 | ||
| 3 Performance and comparability of techniques | 262 | ||
| 4 Conclusion and future perspective | 263 | ||
| Acknowledgments | 264 | ||
| References | 264 |