BOOK
Tu Youyou And The Discovery Of Artemisinin: 2015 Nobel Laureate In Physiology Or Medicine
Rao Yi | Zhang Daqing | Li Runhong
(2016)
Additional Information
Book Details
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Contents | vii | ||
| Authors | ix | ||
| Preface The Deer Bleat “Youyou” While They Feed on Wild Hao | xi | ||
| Chapter 1. Project 523 and Artemisinin | 1 | ||
| The Mandate for Project 523 | 2 | ||
| The project origins | 2 | ||
| The meeting preparations | 3 | ||
| The mission unfolds | 11 | ||
| The Organisational Structure of Project 523 | 14 | ||
| The initial years (1967–1971) | 14 | ||
| Mid-term change of leadership and participating organisations (1971–1981) | 20 | ||
| The conclusion of Project 523 | 24 | ||
| Chapter 2. The Discovery of Artemisinin | 29 | ||
| Rediscovering the Anti-Malarial Properties of Artemisia Annua | 30 | ||
| The Extraction and Naming of the Effective Monomer of A. Annua | 37 | ||
| Academy of Traditional Chinese Medicine (ATCM) | 37 | ||
| Shandong Institute of Parasitic Diseases and Shandong Academy of Chinese Medicine | 39 | ||
| Yunnan Institute of Materia Medica | 40 | ||
| The Structure of Artemisinin | 41 | ||
| Clinical Trials | 45 | ||
| The neutral component of A. annua ethyl ether extracts | 45 | ||
| A. annua (A. annua L.) crystal extracts | 48 | ||
| Collaboration in the Discovery of Artemisinin | 57 | ||
| Within work units | 58 | ||
| Between work units | 59 | ||
| Chapter 3. Scientific Research Collaboration during a Special Historical Period | 63 | ||
| Several Important Meetings | 64 | ||
| The first meeting at the beginning of the project | 64 | ||
| Further meetings as the project gathered momentum | 64 | ||
| The 1971 Guangzhou meeting — further strengthening project 523 | 66 | ||
| The 1973 Shanghai meeting — consolidating and intensifying the research | 68 | ||
| The April 1975 Chengdu meeting — focusing on artemisinin research | 69 | ||
| The 1977 Nanning meeting — preparing for to unveil artemisinin | 70 | ||
| The 1978 Yangzhou meeting — appraisal of artemisinin | 71 | ||
| The 1981 Beijing meeting — the winding up of Project 523 | 71 | ||
| Collaboration between Personnel and Work Units | 73 | ||
| Collaboration between specialist groups | 73 | ||
| Collaboration across different work units or specialisations | 74 | ||
| Chapter 4. Artemisinin’s History and Future | 79 | ||
| From the Past to the Present | 80 | ||
| The sources of artemisinin | 80 | ||
| Artemisia annua: the only natural source of artemisinin | 80 | ||
| The industrialisation of artemisinin production | 81 | ||
| The story behind the discovery of artemisinin | 82 | ||
| The birth of artemisinin from traditional Chinese medicine | 82 | ||
| (2) The catalyst for artemisinin: aiding Vietnam against America | 83 | ||
| National mobilisation in the discovery of artemisinin | 85 | ||
| Health Benefits of Artemisinin and Future Research | 86 | ||
| Anti-malarial effect of artemisinin | 88 | ||
| Chloroquine drug resistance | 88 | ||
| Artemisinin and chloroquine-resistant malaria | 89 | ||
| The anti-malarial effect of artemisinin’s peroxide bridge structure | 90 | ||
| Drug resistance in Plasmodium to artemisinin-based drugs | 90 | ||
| Artemisinin and weight loss | 91 | ||
| Anti-aging effect of artemisinin | 92 | ||
| Anti-inflammatory effect of artemisinin | 95 | ||
| Anti-cancer effect of artemisinin | 96 | ||
| Anti-bacterial effect of artemisinin | 96 | ||
| Chapter 5. The Nobel Prize and Beyond | 101 | ||
| The Revolution is not Yet Over | 102 | ||
| The significance of the Nobel Prize | 102 | ||
| The revolution is not yet over | 105 | ||
| The conflict between Chinese and Western medicine | 107 | ||
| Why was Tu Youyou selected for the Lasker Award? | 109 | ||
| Why was the Nobel Prize awarded to Tu Youyou alone and not her team? | 112 | ||
| Tu Youyou’s Nobel Prize and China’s failure to make nominations | 114 | ||
| How great is the impact of Tu Youyou’s winning of the Nobel Prize? | 117 | ||
| The Importance of Scientific Thinking | 119 | ||
| Chinese Medicine is a Treasure Chest | 126 | ||
| Artemisinin and Malaria | 131 | ||
| Malaria and mankind | 131 | ||
| The discovery and extraction of Artemisinin | 133 | ||
| Further verification by modern experimental science | 135 | ||
| Anti-malarial mechanisms | 136 | ||
| Integrated treatment methods for malaria yield the best results | 138 | ||
| Appendices | 141 | ||
| Appendix 1: Timeline of Project 523 (1964 to 1981) | 142 | ||
| Appendix 2: Milestones in Artemisinin Research (1967 to 2003) | 158 | ||
| Appendix 3: Artemisinin — Patents and Collaboration | 163 | ||
| The regret of failing to patent artemisinin | 163 | ||
| The difficulties of collaboration | 165 | ||
| Appendix 4: Organisations Named | 173 | ||
| Appendix 5: List of Plants | 181 | ||
| Appendix 6: Tu Youyou’s Nobel Lecture 7 Dec 2015 | 183 | ||
| Discovery of Artemisinin | 184 | ||
| Discovery of Artemisinin at ICMM | 184 | ||
| Artemisinin Chemistry Studies | 186 | ||
| Stereo-Structure of Artemisinin | 186 | ||
| Artemisinin and Artemisinin Derivatives | 187 | ||
| Artemisinin and Artemisinin Derivatives | 188 | ||
| Artemisinin and Dihydroartemisinin New Drug Certificates | 190 | ||
| Worldwide Attention on Artemisinin | 190 | ||
| Commitment to the Clearly-Defined Goal Assures Success in Discovery | 191 | ||
| Knowledge is a Prologue in Discovery | 192 | ||
| Information Collating and Accurate Deciphering Are the Foundation for Success in Research | 193 | ||
| Literature Review Inspires an Idea Leading to Success | 194 | ||
| Persistence in the Face of Challenges | 196 | ||
| Collaborative Team Efforts Expedited Translation from Scientific Discovery to Effective Medicine | 197 | ||
| Malaria Remains a Severe Challenge to Global Public Health | 199 | ||
| The Severe Warning of Parasites Resistant to Artemisinin | 201 | ||
| Global Plan for Artemisinin Resistance Containment | 202 | ||
| Chinese Medicine, A Great Treasure | 203 | ||
| On the Stork Tower | 204 | ||
| Editor’s Epilogue | 207 |