BOOK
Alzheimer's Disease Decoded: The History, Present, And Future Of Alzheimer's Disease And Dementia
Sahyouni Ronald | Chen Jefferson William | Verma Aradhana
(2016)
Additional Information
Book Details
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Contents | vii | ||
| About the Authors | ix | ||
| Building a Community | xv | ||
| Foreword | xvii | ||
| Preface | xix | ||
| Quick Reference Guide | xxvii | ||
| Part I: Introduction, History, and Overview | 1 | ||
| Chapter 1: Introduction to the Brain and Nervous System | 3 | ||
| Human Brain: Structure | 5 | ||
| The Nervous System | 9 | ||
| Human Brain: Building Blocks | 10 | ||
| Human Brain: Plasticity | 16 | ||
| Human Brain: Development | 17 | ||
| Human Brain: Organization | 19 | ||
| Human Brain: Memory and Integration | 21 | ||
| Studying the Brain | 25 | ||
| References | 27 | ||
| Chapter 2: Dysfunction | 31 | ||
| Normal Age-related Changes | 32 | ||
| Smell | 36 | ||
| Nervous System Damage and Neurogenesis | 40 | ||
| Neurogenesis in Alzheimer’s and Brain Tumors | 41 | ||
| References | 45 | ||
| Chapter 3: Senility and Normal Aging | 49 | ||
| Is Alzheimer’s Disease a Normal Part of Aging? | 49 | ||
| Where did the Term “Senility” Come From and Why is it Ubiquitously Associated with Aging?\r | 51 | ||
| Cognitive Reserve | 52 | ||
| References | 56 | ||
| Chapter 4: What is Dementia? | 59 | ||
| What Causes Dementia and Alzheimer’s Disease?\r | 64 | ||
| References | 70 | ||
| Chapter 5: Introduction to Alzheimer’s Disease | 73 | ||
| Clinical Symptoms | 76 | ||
| Differential Diagnosis | 79 | ||
| Pathological findings | 85 | ||
| Plaques | 85 | ||
| Tangles | 89 | ||
| Cerebral Amyloid Angiopathy | 90 | ||
| Glial Cell Changes | 90 | ||
| Neuronal and Synaptic Loss | 91 | ||
| Macroscopic Changes | 92 | ||
| Cause of Death | 93 | ||
| Natural History | 94 | ||
| References | 97 | ||
| Chapter 6: Epidemiology of Alzheimer’s Disease | 99 | ||
| Gender and Ethnicity | 100 | ||
| Brain Size and Function | 101 | ||
| Genetics | 101 | ||
| Hormones | 101 | ||
| Social and Behavioral Effects | 103 | ||
| Smoking | 104 | ||
| Ethnicity | 105 | ||
| Global Effects | 106 | ||
| National Effects | 109 | ||
| References | 112 | ||
| Chapter 7: The History of Alzheimer’s Disease | 121 | ||
| The Characterization of the Disease by Dr. Alzheimer in the Early 1900s | 121 | ||
| The Development of the Diagnostic Tools | 125 | ||
| The Development of Medications | 127 | ||
| Clinical Trials Overview | 131 | ||
| Solanezumab | 135 | ||
| References | 137 | ||
| Chapter 8: An Interesting Link | 139 | ||
| Human Brain: Evolution | 139 | ||
| Three Types of Alzheimer’s Disease | 142 | ||
| Trisomy 21 (Down Syndrome) | 145 | ||
| The Interesting Role of Sleep in Alzheimer’s Disease | 146 | ||
| References | 149 | ||
| Part II: Novel Therapies and Future Directions | 153 | ||
| Chapter 9: Surgical Treatments for Dementia | 155 | ||
| Introduction to Neurosurgery and the “Miraculous” Cures of Dementiain Select Disorders\r | 156 | ||
| Surgical Clinical Trials: The Ventriculo- Peritoneal (UP) Shunt Trial\r | 158 | ||
| Stem Cell Trials: Pre-clinical Data and Clinical Trials | 159 | ||
| Deep-Brain Stimulation | 162 | ||
| References | 164 | ||
| Chapter 10: Is There a Link to Traumatic Brain Injury? | 165 | ||
| Chronic Traumatic Encephalopathy | 168 | ||
| TBI in the Military | 169 | ||
| References | 170 | ||
| Chapter 11: What’s going on Now? | 175 | ||
| Vitamin E | 175 | ||
| Medications in the Pipeline | 176 | ||
| Diagnosis | 179 | ||
| Biomarkers and the Alzheimer’s Disease Neuroimaging Initiative Study\r | 184 | ||
| Studying the Disease | 186 | ||
| References | 188 | ||
| Chapter 12: Novel Therapies | 191 | ||
| Stem Cells | 191 | ||
| Lifestyle Modifications | 193 | ||
| Genetic Modification and Personalized Medicine | 202 | ||
| Low-Level Light Therapy | 203 | ||
| Marijuana (THC) | 207 | ||
| THC and Neurogenesis | 209 | ||
| THC and Inflammation | 210 | ||
| Music Therapy | 211 | ||
| References | 215 | ||
| Chapter 13: How Can We Solve the Problem? | 221 | ||
| Caregiving | 222 | ||
| Comprehensive and Integrative Care Clinics | 224 | ||
| Risk Stratification | 224 | ||
| Risk Reduction and Management | 226 | ||
| Early (Correct) Diagnosis | 227 | ||
| Prophylactic Treatment | 228 | ||
| Diet | 229 | ||
| References | 232 | ||
| Chapter 14: What Resources Exist? | 235 | ||
| Global Resources | 236 | ||
| Federal Resources (Lobbying) to Fund Alzheimer’s Research Programs and Scientists | 239 | ||
| Organizational and Support Groups for Families | 240 | ||
| References | 243 | ||
| Acknowledgements | 245 | ||
| Note to Readers | 247 | ||
| Glossary/Abbreviations | 249 | ||
| Index | 255 |