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Adult Brain Tumors, An Issue of Neuroimaging Clinics of North America, E-Book

Adult Brain Tumors, An Issue of Neuroimaging Clinics of North America, E-Book

Lara A. Brandao

(2016)

Additional Information

Abstract

This issue of Neuroimaging Clinics of North America focuses on Adult Brain Tumors, and is edited by Dr. Lara Brandão. Articles will include: Posterior Fossa Tumors in Adult Patients; Lymphomas and Adult Brain Tumors; Pre-Treatment Evaluation of Gliomas; Post Treatment Evaluation of Gliomas; Metastasis in Adult Brain Tumors; Extraparenchymal Lesions in Adult Brain Tumors; Interesting Case Studies in Adult Brain Tumors; Advanced MR Imaging Techniques in Daily Practice; and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Adult Brain Tumors i
Copyright\r ii
CME Accreditation Page iii
PROGRAM OBJECTIVE iii
TARGET AUDIENCE iii
LEARNING OBJECTIVES iii
ACCREDITATION iii
DISCLOSURE OF CONFLICTS OF INTEREST iii
UNAPPROVED/OFF-LABEL USE DISCLOSURE iii
TO ENROLL iii
METHOD OF PARTICIPATION\r iii
CME INQUIRIES/SPECIAL NEEDS iii
NEUROIMAGING CLINICS OF NORTH AMERICA\r iv
FORTHCOMING ISSUES iv
February 2017 iv
May 2017 iv
August 2017 iv
RECENT ISSUES iv
August 2016 iv
May 2016 iv
February 2016 iv
Contributors v
CONSULTING EDITOR v
EDITOR v
AUTHORS v
Contents vii
Foreword: Adult Brain Tumors\r vii
Preface: Adult Brain Tumors: Imaging Characterization of Primary, Secondary, and Extraparenchymal Tumors in the Central Ner ...\r vii
Posterior Fossa Tumors in Adult Patients\r vii
Lymphomas–Part 1\r vii
Lymphomas–Part 2\r vii
Pretreatment Evaluation of Glioma\r viii
Posttreatment Evaluation of Brain Gliomas\r viii
Metastasis in Adult Brain Tumors\r viii
Extraparenchymal Lesions in Adults\r viii
Advanced MR Imaging Techniques in Daily Practice\r viii
Adult Brain Tumors and Pseudotumors: Interesting (Bizarre) Cases\r ix
Foreword:\rAdult Brain Tumors xi
Preface:\rAdult Brain Tumors xiii
Posterior Fossa Tumors in Adult Patients 493
Key points 493
OVERVIEW OF THE POSTERIOR FOSSA 493
MENINGEAL TUMORS: HEMANGIOBLASTOMA (WHO GRADE I) 495
EMBRYONAL TUMORS: MEDULLOBLASTOMA (WHO GRADE IV) 495
ASTROCYTIC TUMORS: PILOCYTIC ASTROCYTOMA (WHO GRADE I) 496
ASTROCYTIC/OLIGODENDROGLIAL TUMORS: DIFFUSE/INFILTRATIVE GLIOMAS (WHO GRADES II–IV) 499
EPENDYMAL TUMORS: SUBEPENDYMOMA AND EPENDYMOMA (WHO GRADES I–III) 501
CHOROID PLEXUS TUMORS AND MENINGIOMA (WHO GRADES I–III) 501
NEURONAL TUMORS: DYSPLASTIC CEREBELLAR GANGLIOCYTOMA (WHO GRADE I) 504
NEURONAL TUMORS: CEREBELLAR LIPONEUROCYTOMA (WHO GRADE II) 506
NEURONAL TUMORS: ROSETTE-FORMING GLIONEURONAL TUMOR OF THE FOURTH VENTRICLE (WHO GRADE I) 506
REFERENCES 508
Lymphomas–Part 1 511
Key points 511
INTRODUCTION 511
IMAGING FINDINGS 512
Location 512
Computed Tomography and Conventional MR Imaging 514
Necrosis and Hemorrhage 514
Calcification 515
Edema 515
Contrast Enhancement 515
IMAGING CHARACTERISTICS ON ADVANCED MR IMAGING 516
Diffusion-Weighted Imaging 516
Diagnostic value 516
Prognostic biomarker 519
Diffusion Tensor Imaging 519
Proton MR Spectroscopy 520
Dynamic Susceptibility Contrast and Dynamic Contrast-Enhanced MR Imaging 521
Diagnostic value 521
Prognostic biomarker 521
POSTTREATMENT CHANGES (RELATED TO STEROIDS) 522
Steroid Therapy, Take Home Messages 530
SUMMARY 534
REFERENCES 534
Lymphomas–Part 2 537
Key points 537
SPECIAL LYMPHOMA TYPES 537
Lymphomatosis Cerebri 537
Pearls 537
Intravascular Lymphoma 537
Epidemiology and risk factors 539
Clinical features 540
Laboratory findings 540
Imaging findings 540
Infarct-like lesions 542
Nonspecific white matter lesions 542
Masslike lesions 542
Meningeal enhancement 542
Hyperintense T2 lesions in the pons 542
Lymphomatoid Granulomatosis 544
Clinical picture 545
Imaging findings 545
DIFFERENTIAL DIAGNOSIS 545
Focal and Multifocal Brain Lesions 545
Glioblastoma 545
Multifocal glioma 546
Multiple sclerosis 546
Contrast enhancement 547
Diffusion-weighted imaging/apparent diffusion coefficient 547
Perfusion and permeability 547
Tumefactive demyelinating lesions 547
Toxoplasmosis 552
Diffusion-weighted imaging/apparent diffusion coefficient 552
Magnetic resonance spectroscopy 553
Perfusion and permeability 553
Infiltrative Diffuse Lesion with No Discernible Mass 553
Lymphomatois cerebri versus gliomatosis cerebri 553
Lymphomatosis cerebri versus microangiopathy (Binswanger disease) 553
Lymphomatosis cerebri versus progressive multifocal leukoencephalopathy 555
Intravascular Lymphoma 555
Intravascular lymphoma versus embolic infarcts 555
Intravascular lymphoma versus vasculitis 557
Ependymal Enhancement 557
Meningeal Enhancement 560
SUMMARY 561
REFERENCES 562
Pretreatment Evaluation of Glioma 567
Key points 567
INTRODUCTION 567
CONVENTIONAL IMAGING TECHNIQUES 568
MODERN IMAGING TECHNIQUES 569
Magnetic Resonance Perfusion Imaging 569
Diffusion-weighted Imaging 570
Susceptibility-weighted Imaging 571
Magnetic Resonance Spectroscopy 571
Functional MR imaging 573
Diffusion Tensor Imaging 575
PET 575
Glucose Metabolism 575
Amino Acid Transport and Protein Synthesis 575
Proliferation Rate 576
Membrane Biosynthesis 576
Oxygen Metabolism 576
Perfusion 576
Biopsy Targeting 576
Radiation Therapy Planning with PET 576
PET/Magnetic Resonance 576
SUMMARY 576
REFERENCES 577
Posttreatment Evaluation of Brain Gliomas 581
Key points 581
INTRODUCTION 581
TUMOR BIOLOGY 582
IMAGING TIME FRAME 582
CHALLENGES WITH IMAGING 582
Mimics of Progression (Increased Enhancement) 583
Subacute infarction and postoperative blood–brain barrier disruption 583
Pseudoprogression 583
Delayed radiation necrosis 583
Mimics of Improvement (Decreased Enhancement) 583
Pseudoresponse 583
RADIOLOGIC INTERPRETATIONS BASED ON ROUTINE PULSE SEQUENCES 584
Response Assessment in Neuro-Oncology Criteria 584
Clinical data to gather before beginning interpretation 585
Enhancement 586
T2/Fluid Attenuation Inversion Recovery Imaging 587
Diffusion Signal 589
ADVANCED MR IMAGING TECHNIQUES 589
Dynamic Susceptibility Contrast-Enhanced Perfusion 589
Dynamic Contrast-Enhanced Perfusion 590
Arterial Spin Labeling Perfusion 590
Choosing a Perfusion Technique 590
Diffusion Tensor Imaging 590
Spectroscopy 590
NUCLEAR MEDICINE TECHNIQUES 593
18Fludeoxyglucose PET 593
Other PET Agents 594
WHAT THE REFERRING CLINICIAN NEEDS TO KNOW 595
SUMMARY 595
REFERENCES 596
Metastasis in Adult Brain Tumors 601
Key points 601
INTRODUCTION 601
NORMAL ANATOMY AND IMAGING TECHNIQUES 602
Anatomy of the Cranial Meninges 602
Preferential Locations of Central Nervous System Metastasis 603
Neuroimaging Approach and Techniques 604
Initial Diagnosis 604
Preoperative and Therapy Planning 607
Post-Treatment Evaluation 607
IMAGING FINDINGS AND PATHOLOGY 610
Skull Metastases 610
Pachymeningeal Carcinomatosis 610
Leptomeningeal Carcinomatosis 613
Parenchymal Metastases 613
Differentiating Progression of Disease from Effects of Stereotactic Radiation Therapy 618
Distinguishing Solitary Metastasis from High-Grade Glioma 618
Pearls, Pitfalls, and Variants 619
Non-neoplastic hematomas 619
Remote microvascular ischemia 619
Ischemic infarction 619
SUMMARY 620
REFERENCES 620
Extraparenchymal Lesions in Adults 621
Key points 621
MENINGIOMA 621
HEMANGIOPERICYTOMA 626
NEUROSARCOIDOSIS 628
LANGERHANS CELL HISTIOCYTOSIS 630
ROSAI-DORFMAN DISEASE 630
PITUITARY MASSES 632
EPIDERMOID AND DERMOID 634
ARACHNOID CYSTS 636
COLLOID CYSTS 637
PINEAL REGION TUMORS 639
SUMMARY 644
REFERENCES 645
Advanced MR Imaging Techniques in Daily Practice 647
Key points 647
INTRODUCTION 647
NORMAL ANATOMY AND IMAGING TECHNIQUE 648
Diffusion-weighted Imaging and Related Techniques (Tagging: Diffusion-weighted Imaging, Diffusion-tensor Imaging) 648
T2* Susceptibility-sensitive Sequences (Tagging: Susceptibility-weighted Imaging, T2*, Susceptibility, Microhemorrhage) 649
Magnetic Resonance Spectroscopy (Tagging: Magnetic Resonance Spectroscopy) 651
Perfusion Imaging (Tagging: Perfusion, Dynamic Susceptibility Contrast Enhanced, Dynamic Contrast Enhanced, Arterial Spin L ... 655
Functional MR Imaging (Tagging: Blood Oxygen Level Dependent, Functional MR Imaging, Resting-state Functional MR Imaging) 658
IMAGING FINDINGS/PATHOLOGY 658
Diffusion-weighted Imaging and Related Techniques (Tagging: Diffusion-weighted Imaging, Diffusion-tensor Imaging) 658
T2* Susceptibility–sensitive Sequences (Tagging: Susceptibility-weighted Imaging, SWAN, T2*, Susceptibility, Microhemorrhage) 660
Magnetic Resonance Spectroscopy (Tagging: Magnetic Resonance Spectroscopy) 660
Perfusion Imaging (Tagging: Perfusion, Dynamic Susceptibility Contrast Enhanced, Dynamic Contrast Enhanced, Arterial Spin L ... 660
Functional MR Imaging (Tagging- Blood Oxygen Level–Dependent, Functional MR Imaging, Resting-state Functional MR Imaging) 661
SUMMARY 663
REFERENCES 663
Adult Brain Tumors and Pseudotumors 667
Key points 667
INTRODUCTION 667
PINEAL CHORIOCARCINOMA 667
Epidemiology 668
Location 668
Clinical Presentation 668
Imaging Findings 668
Histopathology 668
Treatment 669
Differential Diagnosis 669
Prognosis 669
EXTRAVENTRICULAR NEUROCYTOMA 669
Epidemiology 669
Location 669
Clinical Presentation 669
Imaging Findings 669
Histopathology 669
Treatment 670
Index 691