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Sports Cardiology, An Issue of Cardiology Clinics, E-Book

Sports Cardiology, An Issue of Cardiology Clinics, E-Book

Aaron Baggish | Andre La Gerche

(2016)

Additional Information

Book Details

Abstract

This issue of Cardiology Clinics on Sports Cardiology, edited by Drs. Aaron Baggish and Andre La Gerche, will cover a variety of aspects related to cardiovascular health and complications related to athletic activity. Topics covered in this issue include, but are not limited to, molecular aspects of exercise-induced cardiac remodeling; sudden cardiac death; atrial fibrillation in endurance athletes; congenital heart disease in athletes; exercise prescription for the athlete with cardiomyopathy; and advanced exercise testing for the sports cardiologist.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Sports Cardiology i
Copyright\r ii
Contributors iii
EDITORIAL BOARD iii
EDITORS iii
AUTHORS iii
Contents vii
Preface: Sports Cardiology: Comprehensive Clinical Care for Athletes and Highly Active Individuals\r vii
A Modern Definition of the Athlete’s Heart—for Research and the Clinic\r vii
Molecular Aspects of Exercise-induced Cardiac Remodeling\r vii
Sudden Cardiac Death in Athletes: Still Much to Learn\r vii
Using the 12-Lead Electrocardiogram in the Care of Athletic Patients\r viii
Exercise-Induced Atrial Remodeling: The Forgotten Chamber\r viii
Atrial Fibrillation in Endurance Athletes: From Mechanism to Management\r viii
Congenital Heart Disease and the Athlete: What We Know and What We Do Not Know\r viii
Exercise Prescription for the Athlete with Cardiomyopathy\r ix
Beyond the Bruce Protocol: Advanced Exercise Testing for the Sports Cardiologist\r ix
Special Articles ix
Quick Evidence Synopsis: Coronary Artery Revascularization in Patients with Acute Coronary Syndrome and Comorbid Renal Dise \r ix
Quick Evidence Synopsis: Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting for Patients with Coronary A ... ix
CARDIOLOGY CLINICS\r x
FORTHCOMING ISSUES x
February 2017 x
May 2017 x
August 2017 x
RECENT ISSUES x
August 2016 x
May 2016 x
February 2016 x
Preface:\rSports Cardiology: Comprehensive Clinical Care for Athletes and Highly Active Individuals xi
A Modern Definition of the Athlete’s Heart—for Research and the Clinic 507
Key points 507
INTRODUCTION 507
WHAT DETERMINES CARDIAC REMODELING? 508
CRITIQUE OF THE MITCHELL CLASSIFICATION 509
CAN WE DO BETTER? 511
RESEARCH AND THE CLINICAL IMPLICATIONS 511
SUMMARY 512
REFERENCES 513
Molecular Aspects of Exercise-induced Cardiac Remodeling 515
Key points 515
INTRODUCTION 515
MOLECULAR MECHANISMS ASSOCIATED WITH ADAPTIVE EXERCISE-INDUCED CARDIAC REMODELING 516
Cardiac Myocyte Hypertrophy and Renewal/Proliferation 517
Studies specifically assessing cardiac myocyte renewal/proliferation 518
Cardiac Myocyte Contractility and Sarcomeric Remodeling 519
Extracellular Matrix Remodeling 521
Cell Survival 521
Metabolic and Mitochondrial Adaptations 521
Electrical Remodeling 521
Angiogenesis and Vascular Remodeling 522
Emerging Role of microRNAs in Exercise-induced Cardiac Remodeling 522
Other Factors Affecting Exercise-induced Cardiac Remodeling 523
MOLECULAR MECHANISMS ASSOCIATED WITH MALADAPTIVE EXERCISE-INDUCED CARDIAC REMODELING 523
THERAPEUTIC APPROACHES THAT TARGET KEY MECHANISMS RESPONSIBLE FOR EXERCISE-INDUCED ADAPTIVE CARDIAC REMODELING 523
Gene Therapy 524
MicroRNA-based Treatments 524
Small Molecules That Activate the Insulin-like Growth Factor 1–Phosphoinositide 3-Kinase–-Protein Kinase B Signaling Cascade 525
Small molecule–activating insulin-like growth factor 1 receptor 525
Small molecule–activating protein kinase B 525
SUMMARY 525
REFERENCES 525
Sudden Cardiac Death in Athletes 531
Key points 531
INTRODUCTION 531
INCIDENCE OF SUDDEN CARDIAC DEATH IN ATHLETES 532
CAUSES OF SUDDEN CARDIAC DEATH IN ATHLETES 532
Inherited Structural Diseases 534
Hypertrophic cardiomyopathy 534
Arrhythmogenic right ventricular cardiomyopathy/dysplasia 534
Inherited Arrhythmia Disorders 534
Long QT syndrome 534
Catecholaminergic polymorphic ventricular tachycardia 534
Acquired Causes of Sudden Cardiac Death 535
WHEN TRAGEDY STRIKES: FOLLOWING THE SUDDEN CARDIAC DEATH OF AN ATHLETE 535
Comprehensive Postmortem Examination 535
Clinical Screening of the Family 536
Role of the Molecular Autopsy 537
STILL MUCH TO LEARN 537
SUMMARY 538
REFERENCES 539
Using the 12-Lead Electrocardiogram in the Care of Athletic Patients 543
Key points 543
INTRODUCTION 543
DEFINITION OF AN ATHLETE 543
ORIGINS OF THE ATHLETE’S HEART 544
THE ATHLETE’S ELECTROCARDIOGRAM 544
DETERMINANTS OF ELECTROCARDIOGRAM PATTERNS IN ATHLETES 544
Age 545
Gender 546
Ethnicity 546
TYPE AND INTENSITY OF SPORT 546
SUDDEN CARDIAC DEATH IN ATHLETES 547
THE ELECTROCARDIOGRAM'S ROLE IN DIAGNOSIS, PROGNOSIS, AND RISK STRATIFICATION OF POTENTIALLY SERIOUS CARDIOVASCULAR ABNORMA ... 547
THE EVOLUTION OF ELECTROCARDIOGRAM INTERPRETATION IN ATHLETES 548
THE EUROPEAN SOCIETY OF CARDIOLOGY CRITERIA 549
THE SEATTLE CRITERIA 549
THE REFINED CRITERIA 550
FUTURE PROGRESS 550
DOES ELECTROCARDIOGRAM SCREENING SAVE LIVES? 551
LIMITATIONS OF THE ELECTROCARDIOGRAM 553
Variation in Interpretation 553
Cardiac Conditions Undetectable by Electrocardiogram 553
MASTERS ATHLETES 553
SUMMARY 553
REFERENCES 553
Exercise-Induced Atrial Remodeling 557
Key points 557
BACKGROUND 557
ECHOCARDIOGRAPHY ATRIAL ABNORMALITIES IN ATHLETES 558
LEFT ATRIAL ECHOCARDIOGRAPHIC EVALUATION: FROM STANDARD MEASUREMENTS TO NEW ECHO TECHNOLOGIES 558
LEFT ATRIAL DIAMETER IN ATHLETES 560
LEFT ATRIAL VOLUME INDEX IN ATHLETES 560
LEFT ATRIAL MYOCARDIAL FUNCTION IN ATHLETES 561
CLINICAL IMPACT: ATRIAL FIBRILLATION IN ATHLETES 561
CARDIAC MAGNETIC RESONANCE AND LEFT ATRIAL MORPHOLOGY IN ATHLETES 563
SUMMARY 563
REFERENCES 564
Atrial Fibrillation in Endurance Athletes 567
Key points 567
INTRODUCTION 567
PREVALENCE OF ATRIAL ARRHYTHMIAS IN ENDURANCE ATHLETES 568
Searching for a Common Definition 568
MECHANISMS IN THE PATHOGENESIS OF ATRIAL FIBRILLATION IN ATHLETES 569
Atrial Structural Remodeling 569
Autonomic Influences 570
Atrial Ectopic Triggers 570
MANAGEMENT OF ATRIAL FIBRILLATION IN ATHLETES 571
Evaluation of an Athlete with Atrial Fibrillation 571
Detraining 571
Rate Control 571
Rhythm Control 573
Anticoagulation 574
FUTURE DIRECTIONS 575
SUMMARY 575
REFERENCES 576
Congenital Heart Disease and the Athlete 579
Key points 579
CASE EXAMPLES 579
INTRODUCTION 580
THE CASE FOR PARTICIPATION 580
RESTRICTING PATIENTS SHOULD NOT BE TAKEN LIGHTLY (AND ONLY DONE WHEN THERE IS EVIDENCE TO RESTRICT AND NOT THE OTHER WAY AR ... 580
THE CASE FOR RESTRICTION 580
WHAT IS KNOWN ABOUT THE SUBJECT 584
Risk of Sudden Death in Patients with Congenital Heart Disease 584
Physiologic Changes with Exercise 584
Exercise Training and Sports Improve Short-term Fitness Measurements 584
Physicians Do Not Universally Follow the Congenital Heart Disease Sports Participation Guidelines 584
If Sudden Cardiac Arrest Occurs, the Athlete May Be Safer at a Training Facility or Sporting Event Instead of an Unsupervis ... 585
WHAT IS NOT KNOWN ABOUT THE SUBJECT 585
The Risk of Sudden Death with Exercise in Each Patient with Congenital Heart Disease 585
Long-term Physiologic Changes Due to Exercise 585
Can You Positively Motivate Somebody to Participate in Sports or to Exercise? 585
RETURNING TO THE CASE EXAMPLES 585
SUMMARY 586
REFERENCES 586
Exercise Prescription for the Athlete with Cardiomyopathy 591
Key points 591
INHERITED CARDIOMYOPATHIES PRIMER 591
Hypertrophic Cardiomyopathy 591
Dilated Cardiomyopathy 592
Left Ventricle Noncompaction 592
Arrhythmogenic Right Ventricular Cardiomyopathy 593
INCIDENCE OF SUDDEN CARDIAC DEATH IN ATHLETES 593
RISK AND CAUSE OF SUDDEN CARDIAC DEATH IN ATHLETES WITH CARDIOMYOPATHY 594
GUIDELINES: BETHESDA AND BEYOND 596
APPROACH TO THE ATHLETE WITH CARDIOMYOPATHY 597
SUMMARY 598
REFERENCES 599
Beyond the Bruce Protocol 603
Key points 603
INTRODUCTION 603
GRADED EXERCISE TESTING 604
NONGRADED EXERCISE TESTING 604
REMOTE EXERCISE MONITORING 606
CASE STUDY 606
SUMMARY 607
SUPPLEMENTARY DATA 607
REFERENCES 607
Quick Evidence Synopsis 609
AUTHOR COMMENTARY 612
GLOSSARY 613
RECOMMENDED CITATION 613
DISCLAIMER 613
REFERENCES 613
Quick Evidence Synopsis 615
AUTHOR COMMENTARY 619
GLOSSARY 619
RECOMMENDED CITATION 619
DISCLAIMER 619
REFERENCES 620
Index 623