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Diagnostic Atlas of Renal Pathology E-Book

Diagnostic Atlas of Renal Pathology E-Book

Agnes B. Fogo | Michael Kashgarian

(2016)

Additional Information

Book Details

Abstract

Recognize and diagnose a wide range of renal pathologic entities with Diagnostic Atlas of Renal Pathology, 3rd Edition. In this edition, Drs. Agnes B. Fogo and Michael Kashgarian use hundreds of high-quality illustrations to clearly depict the pathologic features and clinical manifestations of both common and rare renal disorders. Extensive updates to the text keep you current with the knowledge you need for clinical practice or continuing education and certification.

  • More than 700 images of light, immunofluorescence, and electron microscopy for each diagnostic entity with correlations to clinical presentation and pathogenesis.
  • Focused, detailed discussions on key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information.
  • An in-depth examination of pathophysiology, clinical presentations, and the latest evidence-based practices.
  • User-friendly format features tables and sidebars with key points and differential diagnoses, and chapters that include concise, templated discussions regarding the etiology and pathogenesis of the disorder.
  • Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
  • A new chapter describing a logical approach to differential diagnosis.
  • New insights into pathogenesis and classification of diseases.
  • New coverage of aging and the kidney, endemic diseases, transplant, lupus-related kidney diseases, Mesoamerican nephropathy, ApolL1-related nephropathies, C3 glomerulopathies, and thrombotic microangiopathies.
  • Recent results of consensus conferences on vasculitides and renal neoplasia.

Table of Contents

Section Title Page Action Price
Front Cover Cover
IFC ES1
DIAGNOSTIC ATLAS OF RENAL PATHOLOGY i
DIAGNOSTIC ATLAS OF RENAL PATHOLOGY iii
Copyright iv
Preface v
Acknowledgments vii
Contents ix
DIAGNOSTIC ATLAS OF RENAL PATHOLOGY xiii
1 - Approach to Diagnosis of the Kidney Biopsy 1
2 - Normal Growth and Maturation 9
3 - Glomerular Diseases 19
Glomerular Diseases That Cause Nephrotic Syndrome: Non-Immune Complex 20
MINIMAL CHANGE DISEASE AND FOCAL SEGMENTAL GLOMERULOSCLEROSIS: INTRODUCTION 20
MINIMAL CHANGE DISEASE 20
Etiology/Pathogenesis 22
FOCAL SEGMENTAL GLOMERULOSCLEROSIS 25
Diagnosis of Recurrence of FSGS in the Transplant 29
Etiology/Pathogenesis 34
Collapsing Glomerulopathy 37
Etiology/Pathogenesis 39
Tip Lesion Variant of FSGS 43
Etiology/Pathogenesis 45
Cellular Variant of FSGS 45
Etiology/Pathogenesis 46
Perihilar Variant of FSGS 46
Etiology/Pathogenesis—Secondary Forms of FSGS 47
CONGENITAL NEPHROTIC SYNDROME OF FINNISH TYPE 49
Etiology/Pathogenesis 50
DIFFUSE MESANGIAL SCLEROSIS 52
Frasier Syndrome 54
Etiology/Pathogenesis 55
Glomerular Diseases That Cause Nephrotic/Nephritic Syndrome: Complement Related 57
C1Q NEPHROPATHY 57
Etiology/Pathogenesis 58
C3 GLOMERULOPATHIES 59
Dense Deposit Disease 60
Etiology/Pathogenesis 61
C3 Glomerulonephritis 66
Etiology/Pathogenesis 69
Glomerular Diseases That Cause Nephrotic Syndrome: Immune Complex 71
MEMBRANOUS NEPHROPATHY 71
Etiology/Pathogenesis 82
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS 88
Etiology/Pathogenesis 93
FIBRILLARY GLOMERULONEPHRITIS 100
Etiology/Pathogenesis 105
IMMUNOTACTOID GLOMERULOPATHY 108
Etiology/Pathogenesis 108
Glomerular Diseases That Cause Hematuria or Nephritic Syndrome: Immune Complex 112
ACUTE POSTINFECTIOUS GLOMERULONEPHRITIS 112
Etiology/Pathogenesis 115
IGA NEPHROPATHY 122
Etiology/Pathogenesis 129
Secondary Glomerular Diseases 134
Diseases Associated With Nephrotic Syndrome 134
MONOCLONAL IMMUNOGLOBULIN DEPOSITION DISEASE 134
Light Chain Deposition Disease 135
Light and Heavy Chain Deposition Disease and Heavy Chain Deposition Disease 140
Etiology/Pathogenesis of MIDD 146
AMYLOIDOSIS 147
Etiology/Pathogenesis 159
PROLIFERATIVE GLOMERULONEPHRITIS WITH MONOCLONAL DEPOSITS 161
Etiology/Pathogenesis 164
HIV-ASSOCIATED NEPHROPATHY 164
Etiology/Pathogenesis 169
SICKLE CELL NEPHROPATHY 170
Etiology/Pathogenesis 176
FABRY DISEASE 177
Etiology/Pathogenesis 182
LIPOPROTEIN GLOMERULOPATHY 183
LECITHIN-CHOLESTEROL ACYLTRANSFERASE (LCAT) DEFICIENCY 185
Etiology/Pathogenesis 187
HEREDITARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS 188
Diseases Associated With Nephritic Syndrome or Rapidly Progressive Glomerulonephritis (RPGN): Immune Mediated 190
LUPUS NEPHRITIS 190
Histopathology 193
Class I Minimal Mesangial Lupus Nephritis 193
Class II Mesangial Proliferative Lupus Nephritis 193
Class III Focal Lupus Nephritis 197
Class IV Diffuse Lupus Nephritis 200
Class V Membranous Lupus Nephritis 207
Class VI Advanced Sclerosing Lupus Nephritis 209
ATYPICAL PRESENTATIONS OF RENAL INVOLVEMENT IN SLE 209
Lupus Podocytopathy/Minimal Change Disease 209
ANCA-Associated Nephritis 212
Mixed Patterns and Transformation 213
Immunofluorescence Microscopic Features 213
Additional Pathologic Features 214
Vascular Lesions 214
Tubulointerstitial Disease 215
Assessment of Severity and Chronicity 217
Etiology/Pathogenesis 218
HENOCH–SCHÖNLEIN PURPURA (IGA VASCULITIS) 219
Etiology/Pathogenesis 220
MIXED CONNECTIVE TISSUE DISEASE 230
Etiology/Pathogenesis 230
MIXED CRYOGLOBULINEMIA 236
Etiology/Pathogenesis 246
ANTI-GBM ANTIBODY–MEDIATED GLOMERULONEPHRITIS 246
Etiology/Pathogenesis 252
Diseases Associated With the Nephritic Syndrome or RPGN: Antineutrophil Cytoplasmic Autoantibody (ANCA)–Associated Small-Vessel ... 254
INTRODUCTION 254
MICROSCOPIC POLYANGIITIS (MPA) 256
4 - Vascular Diseases 295
Diabetic Nephropathy 295
Thrombotic Microangiopathy/Thrombotic Thrombocytopenic Purpura 307
Scleroderma (Systemic Sclerosis) 321
Antiphospholipid Antibody Disease 328
Preeclampsia and Eclampsia 329
PATHOLOGY 329
Etiology/Pathogenesis 337
Fibromuscular Dysplasia 338
PATHOLOGY 338
Arterionephrosclerosis 343
Accelerated/Malignant Hypertension 354
Atheroemboli 359
5 - Tubulointerstitial Diseases 365
Introduction 366
Infections of the Kidney 367
Acute Pyelonephritis 367
Chronic Pyelonephritis and Reflux Nephropathy 373
Xanthogranulomatous Pyelonephritis 376
Malakoplakia 378
Acute Tubulointerstitial Nephritis—Viral Infection 380
Acute Tubulointerstitial Nephritis—Drug-Related 380
Tubulointerstitial Nephritis With Uveitis 387
Anti-Tubular Basement Membrane Antibody Nephritis 388
Idiopathic Hypocomplementemic Tubulointerstitial Nephritis 390
IgG4-Related Tubulointerstitial Nephritis 391
Interstitial Nephritis of Sjögren Syndrome 396
Sarcoidosis 397
Acute Kidney Injury/Acute Tubular Necrosis 400
ISCHEMIC ACUTE TUBULAR INJURY 401
ACUTE PHOSPHATE NEPHROPATHY 408
Etiology/Pathogenesis 409
NEPHROTOXIC ACUTE TUBULAR NECROSIS 412
Etiology/Pathogenesis 414
Warfarin-Induced Acute Kidney Injury/Anticoagulant-Related Nephropathy 421
Heavy Metal Nephropathy (Lead and Cadmium Nephropathy) 421
Analgesic Nephropathy and Papillary Necrosis 422
Light Chain Cast Nephropathy and Tubulopathy 425
Tubular Crystallopathies 435
CYSTINOSIS 435
Etiology/Pathogenesis 437
NEPHROCALCINOSIS 440
Etiology/Pathogenesis 441
OXALOSIS 441
Etiology/Pathogenesis 443
URATE NEPHROPATHY 446
Etiology/Pathogenesis 446
INDINAVIR NEPHROPATHY 447
Etiology/Pathogenesis 448
Lithium Nephropathy 448
Aristolochic Acid Nephropathy 448
6 - Endemic Nephropathies 449
Introduction 449
Aristolochic Acid Nephropathy (Chinese Herb Nephropathy, Balkan Endemic Nephropathy) 450
Other Endemic Fibrosing Nephropathies 451
OCHRATOXIN NEPHROPATHY 451
CHRONIC KIDNEY DISEASE OF UNKNOWN ETIOLOGY IN SRI LANKA 451
MESOAMERICAN NEPHROPATHY 452
APOLIPOPROTEIN L1-ASSOCIATED NEPHROPATHIES 453
7 - Chronic Kidney Disease 457
Introduction 457
Age-Related Sclerosis 459
Glomerular Versus Tubulointerstitial Versus Vascular Disease 460
Segmental Glomerulosclerosis: Primary Versus Secondary 461
8 - Renal Transplantation 463
Introduction 463
Evaluation of Donor Kidneys 466
Antibody-Mediated Rejection 467
Chronic Active Antibody-Mediated Rejection and Transplant Glomerulopathy 469
Acute T Cell–Mediated Rejection 471
BORDERLINE CHANGES: “SUSPICIOUS FOR ACUTE REJECTION” 471
BANFF TYPE I ACUTE REJECTION 472
BANFF TYPE II ACUTE REJECTION 473
BANFF TYPE III ACUTE REJECTION 473
Chronic Active T–Cell Mediated Rejection 476
Cyclosporin/Tacrolimus Nephrotoxicity 478
Sirolimus (Rapamycin) Nephrotoxicity 481
Posttransplant Lymphoproliferative Disease 481
Viral Infections 483
Recurrent Renal Disease 488
9 - Cystic Diseases of the Kidney 491
Introduction 491
Autosomal Dominant Polycystic Kidney Disease 491
Pathology 492
10 - Renal Neoplasia 511
Introduction 511
Renal Neoplasms 511
BENIGN EPITHELIAL NEOPLASMS 511
RENAL CELL CARCINOMAS 512
Etiology/Pathogenesis 524
Nephroblastoma (Wilms Tumor) 525
Renal Angiomyolipoma 528
Urothelial (Transitional Cell) Carcinoma of the Renal Pelvis 529
Index 531
A 531
B 532
C 532
D 534
E 534
F 535
G 536
H 536
I 537
J 538
K 538
L 539
M 540
N 541
O 541
P 541
R 543
S 543
T 544
U 545
V 545
W 546
X 546
IBC ES2