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Diagnostic Pathology: Neoplastic Dermatopathology E-Book

Diagnostic Pathology: Neoplastic Dermatopathology E-Book

David S. Cassarino

(2016)

Additional Information

Book Details

Abstract

Ideal for pathologists, dermatopathologists, and dermatologists alike, Diagnostic Pathology: Neoplastic Dermatopathology, second edition offers the latest findings with regard to the interpretation and diagnosis of cutaneous neoplasms. Its detailed format with lavish illustrations facilitates the clinician’s ability to quickly locate relevant information. Concise, bulleted text with extensive illustrations expedites access to the important medical details for diagnosis.

  • Includes the latest information on new diagnostic immunohistochemical, molecular, and genetic tests
  • Carefully annotated images highlight the most diagnostically significant considerations
  • Analyzes hundreds of diagnoses, each of which include definitions, terminology, etiology, pathogenesis, demographics, clinical presentations, therapy, prognosis, gross and microscopic pathology, differential diagnoses, and special studies including immunohistochemistry and molecular/genetics

Table of Contents

Section Title Page Action Price
Front Cover Cover
Diagnostic Pathology: Neoplastic Dermatopathology iii
Copyright Page iv
Table of Contents xiv
Dedications v
Contributing Authors vi
Preface ix
Acknowledgments xi
Sections xiii
Part I: Nonmelanocytic Tumors of\rSkin 3
SECTION 1:\rEpithelial Cysts 3
Chapter 1.\rEpidermoid/Epidermal Inclusion Cyst 4
TERMINOLOGY 5
ETIOLOGY/PATHOGENESIS 5
CLINICAL ISSUES 5
MACROSCOPIC 5
MICROSCOPIC 5
DIFFERENTIAL DIAGNOSIS 5
DIAGNOSTIC CHECKLIST 5
SELECTED REFERENCES 5
Chapter 2. Pilar (Tricholemmal) Cyst 6
TERMINOLOGY 7
CLINICAL ISSUES 7
MACROSCOPIC 7
MICROSCOPIC 7
DIFFERENTIAL DIAGNOSIS 7
DIAGNOSTIC CHECKLIST 7
SELECTED REFERENCES 7
Chapter\r3. Proliferating Pilar (Tricholemmal) Cyst/Tumor 8
TERMINOLOGY 9
ETIOLOGY/PATHOGENESIS 9
CLINICAL ISSUES 9
MACROSCOPIC 9
MICROSCOPIC 9
DIFFERENTIAL DIAGNOSIS 9
SELECTED REFERENCES 9
Chapter\r4. HPV-Related Epidermal Cyst 12
TERMINOLOGY 13
ETIOLOGY/PATHOGENESIS 13
CLINICAL ISSUES 13
MACROSCOPIC 13
MICROSCOPIC 13
ANCILLARY TESTS 13
DIFFERENTIAL DIAGNOSIS 13
DIAGNOSTIC CHECKLIST 13
SELECTED REFERENCES 13
Chapter\r5. Vellus Hair Cyst 14
TERMINOLOGY 15
ETIOLOGY/PATHOGENESIS 15
CLINICAL ISSUES 15
MACROSCOPIC 15
MICROSCOPIC 15
DIFFERENTIAL DIAGNOSIS 15
DIAGNOSTIC CHECKLIST 15
SELECTED REFERENCES 15
Chapter\r6. Steatocystoma (Multiplex) 16
TERMINOLOGY 17
CLINICAL ISSUES 17
MACROSCOPIC 17
MICROSCOPIC 17
DIFFERENTIAL DIAGNOSIS 17
DIAGNOSTIC CHECKLIST 17
SELECTED REFERENCES 17
Chapter\r7. Cutaneous Keratocyst 18
TERMINOLOGY 19
ETIOLOGY/PATHOGENESIS 19
CLINICAL ISSUES 19
MACROSCOPIC 19
MICROSCOPIC 19
DIFFERENTIAL DIAGNOSIS 19
DIAGNOSTIC CHECKLIST 19
SELECTED REFERENCES 19
Chapter\r8. Milial Cysts 20
TERMINOLOGY 21
CLINICAL ISSUES 21
MACROSCOPIC 21
MICROSCOPIC 21
DIFFERENTIAL DIAGNOSIS 21
DIAGNOSTIC CHECKLIST 21
SELECTED REFERENCES 21
Chapter\r9. Hidrocystoma (Apocrine and Eccrine) 22
TERMINOLOGY 23
ETIOLOGY/PATHOGENESIS 23
CLINICAL ISSUES 23
MACROSCOPIC 23
MICROSCOPIC 23
DIFFERENTIAL DIAGNOSIS 23
DIAGNOSTIC CHECKLIST 23
SELECTED REFERENCES 23
Chapter\r10. Digital Mucous Cyst 24
TERMINOLOGY 25
ETIOLOGY/PATHOGENESIS 25
CLINICAL ISSUES 25
MACROSCOPIC 25
MICROSCOPIC 25
DIFFERENTIAL DIAGNOSIS 25
DIAGNOSTIC CHECKLIST 25
SELECTED REFERENCES 25
Chapter\r11. Bronchogenic Cyst 26
TERMINOLOGY 27
ETIOLOGY/PATHOGENESIS 27
CLINICAL ISSUES 27
IMAGING 27
MACROSCOPIC 27
MICROSCOPIC 27
ANCILLARY TESTS 27
DIFFERENTIAL DIAGNOSIS 27
SELECTED REFERENCES 27
Chapter\r12. Branchial Cleft Cyst 28
TERMINOLOGY 29
ETIOLOGY/PATHOGENESIS 29
CLINICAL ISSUES 29
IMAGING 30
MACROSCOPIC 30
MICROSCOPIC 30
ANCILLARY TESTS 30
DIFFERENTIAL DIAGNOSIS 30
SELECTED REFERENCES 31
Chapter\r13. Median Raphe Cyst 34
TERMINOLOGY 35
ETIOLOGY/PATHOGENESIS 35
CLINICAL ISSUES 35
MACROSCOPIC 35
MICROSCOPIC 35
ANCILLARY TESTS 35
DIFFERENTIAL DIAGNOSIS 35
DIAGNOSTIC CHECKLIST 35
SELECTED REFERENCES 35
Chapter\r14. Cutaneous Ciliated Cyst 36
TERMINOLOGY 37
ETIOLOGY/PATHOGENESIS 37
CLINICAL ISSUES 37
MACROSCOPIC 37
MICROSCOPIC 37
ANCILLARY TESTS 37
DIFFERENTIAL DIAGNOSIS 37
DIAGNOSTIC CHECKLIST 37
SELECTED REFERENCES 37
SECTION 2:\rEpidermal Tumors 39
Benign Epidermal Tumors and\rProliferative Lesions 40
Chapter\r15. Epidermal Nevus 40
TERMINOLOGY 41
ETIOLOGY/PATHOGENESIS 41
CLINICAL ISSUES 41
MACROSCOPIC 41
MICROSCOPIC 41
DIFFERENTIAL DIAGNOSIS 41
SELECTED REFERENCES 41
Chapter\r16. Seborrheic Keratosis (and Variants) 44
TERMINOLOGY 45
ETIOLOGY/PATHOGENESIS 45
CLINICAL ISSUES 45
MACROSCOPIC 45
MICROSCOPIC 45
DIFFERENTIAL DIAGNOSIS 46
DIAGNOSTIC CHECKLIST 46
SELECTED REFERENCES 46
Chapter\r17. Pseudoepitheliomatous Hyperplasia 50
TERMINOLOGY 51
ETIOLOGY/PATHOGENESIS 51
CLINICAL ISSUES 51
MICROSCOPIC 51
DIFFERENTIAL DIAGNOSIS 51
DIAGNOSTIC CHECKLIST 51
SELECTED REFERENCES 51
Chapter\r18. Warty Dyskeratoma 52
TERMINOLOGY 53
ETIOLOGY/PATHOGENESIS 53
CLINICAL ISSUES 53
MICROSCOPIC 53
DIFFERENTIAL DIAGNOSIS 53
DIAGNOSTIC CHECKLIST 53
SELECTED REFERENCES 53
Chapter\r19. Acantholytic and Acantholytic Dyskeratotic Acanthoma 54
TERMINOLOGY 55
CLINICAL ISSUES 55
MICROSCOPIC 55
DIFFERENTIAL DIAGNOSIS 55
DIAGNOSTIC CHECKLIST 55
SELECTED REFERENCES 55
Chapter\r20. Verruca Vulgaris (and Variants) 56
TERMINOLOGY 57
ETIOLOGY/PATHOGENESIS 57
CLINICAL ISSUES 57
MACROSCOPIC 57
MICROSCOPIC 57
DIFFERENTIAL DIAGNOSIS 57
SELECTED REFERENCES 57
Chapter\r21. Condyloma Acuminatum (Genital Wart) 60
TERMINOLOGY 61
ETIOLOGY/PATHOGENESIS 61
CLINICAL ISSUES 61
MACROSCOPIC 61
MICROSCOPIC 61
ANCILLARY TESTS 62
DIFFERENTIAL DIAGNOSIS 62
DIAGNOSTIC CHECKLIST 62
SELECTED REFERENCES 62
Chapter\r22. Prurigo Nodularis 64
TERMINOLOGY 65
ETIOLOGY/PATHOGENESIS 65
CLINICAL ISSUES 65
MICROSCOPIC 65
DIFFERENTIAL DIAGNOSIS 65
SELECTED REFERENCES 65
Chapter\r23. Large Cell Acanthoma 66
TERMINOLOGY 67
ETIOLOGY/PATHOGENESIS 67
CLINICAL ISSUES 67
MACROSCOPIC 67
MICROSCOPIC 67
ANCILLARY TESTS 67
DIFFERENTIAL DIAGNOSIS 67
SELECTED REFERENCES 67
Chapter\r24. Clear Cell Acanthoma 68
TERMINOLOGY 69
ETIOLOGY/PATHOGENESIS 69
CLINICAL ISSUES 69
MACROSCOPIC 69
MICROSCOPIC 69
DIFFERENTIAL DIAGNOSIS 69
DIAGNOSTIC CHECKLIST 69
SELECTED REFERENCES 69
Chapter\r25. Clear Cell Papulosis 70
TERMINOLOGY 71
ETIOLOGY/PATHOGENESIS 71
CLINICAL ISSUES 71
MICROSCOPIC 71
DIFFERENTIAL DIAGNOSIS 71
DIAGNOSTIC CHECKLIST 71
SELECTED REFERENCES 71
Chapter\r26. Toker Cell Hyperplasia 72
TERMINOLOGY 73
CLINICAL ISSUES 73
MICROSCOPIC 73
DIFFERENTIAL DIAGNOSIS 73
DIAGNOSTIC CHECKLIST 73
SELECTED REFERENCES 73
Premalignant and Malignant Epidermal Tumors 74
Chapter\r27. Actinic Keratosis 74
TERMINOLOGY 75
ETIOLOGY/PATHOGENESIS 75
CLINICAL ISSUES 75
MACROSCOPIC 75
MICROSCOPIC 75
ANCILLARY TESTS 76
DIFFERENTIAL DIAGNOSIS 76
SELECTED REFERENCES 76
Chapter\r28. Actinic Cheilitis 78
TERMINOLOGY 79
ETIOLOGY/PATHOGENESIS 79
CLINICAL ISSUES 79
MICROSCOPIC 79
DIFFERENTIAL DIAGNOSIS 79
SELECTED REFERENCES 79
Chapter\r29. Squamous Cell Carcinoma In Situ (Bowen Disease) 80
TERMINOLOGY 81
ETIOLOGY/PATHOGENESIS 81
CLINICAL ISSUES 81
MACROSCOPIC 81
MICROSCOPIC 81
DIFFERENTIAL DIAGNOSIS 81
SELECTED REFERENCES 81
Chapter\r30. Bowenoid Papulosis 84
TERMINOLOGY 85
ETIOLOGY/PATHOGENESIS 85
CLINICAL ISSUES 85
MICROSCOPIC 85
DIFFERENTIAL DIAGNOSIS 85
DIAGNOSTIC CHECKLIST 85
SELECTED REFERENCES 85
Chapter\r31. Penile and Vulvar Intraepithelial Neoplasia 86
TERMINOLOGY 87
ETIOLOGY/PATHOGENESIS 87
CLINICAL ISSUES 87
MACROSCOPIC 87
MICROSCOPIC 87
ANCILLARY TESTS 88
DIFFERENTIAL DIAGNOSIS 88
DIAGNOSTIC CHECKLIST 88
SELECTED REFERENCES 88
Chapter\r32. Epidermodysplasia Verruciformis 90
TERMINOLOGY 91
ETIOLOGY/PATHOGENESIS 91
CLINICAL ISSUES 91
MICROSCOPIC 91
DIFFERENTIAL DIAGNOSIS 91
DIAGNOSTIC CHECKLIST 91
SELECTED REFERENCES 91
Chapter\r33. Verrucous Carcinoma (and Variants) 92
TERMINOLOGY 93
ETIOLOGY/PATHOGENESIS 93
CLINICAL ISSUES 93
MACROSCOPIC 93
MICROSCOPIC 93
ANCILLARY TESTS 93
DIFFERENTIAL DIAGNOSIS 93
DIAGNOSTIC CHECKLIST 94
SELECTED REFERENCES 94
Chapter\r34. Squamous Cell Carcinoma (and Variants) 98
TERMINOLOGY 99
ETIOLOGY/PATHOGENESIS 99
CLINICAL ISSUES 99
MACROSCOPIC 99
MICROSCOPIC 99
ANCILLARY TESTS 100
DIFFERENTIAL DIAGNOSIS 100
DIAGNOSTIC CHECKLIST 100
SELECTED REFERENCES 100
Chapter\r35. Keratoacanthoma 104
TERMINOLOGY 105
ETIOLOGY/PATHOGENESIS 105
CLINICAL ISSUES 105
MACROSCOPIC 105
MICROSCOPIC 105
DIFFERENTIAL DIAGNOSIS 105
SELECTED REFERENCES 105
Chapter\r36. Lymphoepithelioma-Like Carcinoma of Skin 108
TERMINOLOGY 109
ETIOLOGY/PATHOGENESIS 109
CLINICAL ISSUES 109
MICROSCOPIC 109
ANCILLARY TESTS 109
DIFFERENTIAL DIAGNOSIS 109
DIAGNOSTIC CHECKLIST 109
SELECTED REFERENCES 109
Chapter\r37. Basal Cell Carcinoma 110
TERMINOLOGY 111
ETIOLOGY/PATHOGENESIS 111
CLINICAL ISSUES 111
MACROSCOPIC 111
MICROSCOPIC 111
ANCILLARY TESTS 111
DIFFERENTIAL DIAGNOSIS 112
DIAGNOSTIC CHECKLIST 112
SELECTED REFERENCES 112
Chapter\r38. Extramammary Paget Disease 116
TERMINOLOGY 117
ETIOLOGY/PATHOGENESIS 117
CLINICAL ISSUES 117
MACROSCOPIC 117
MICROSCOPIC 117
ANCILLARY TESTS 118
DIFFERENTIAL DIAGNOSIS 118
DIAGNOSTIC CHECKLIST 118
SELECTED REFERENCES 118
Chapter\r39. Squamomelanocytic Tumor 120
TERMINOLOGY 121
ETIOLOGY/PATHOGENESIS 121
CLINICAL ISSUES 121
MICROSCOPIC 121
ANCILLARY TESTS 121
DIFFERENTIAL DIAGNOSIS 121
SELECTED REFERENCES 121
Chapter\r40. Staging for Specimens of Squamous Cell Carcinoma of Skin 122
TERMINOLOGY 122
SELECTED REFERENCES 122
SECTION 3:\rTumors and Tumor-Like\rConditions of the Hair Follicle 125
Chapter\r41. Nevus Sebaceus and Follicular Hamartomas 126
TERMINOLOGY 127
ETIOLOGY/PATHOGENESIS 127
CLINICAL ISSUES 127
MICROSCOPIC 127
DIFFERENTIAL DIAGNOSIS 127
SELECTED REFERENCES 127
Chapter 42. Trichofolliculoma 130
TERMINOLOGY 131
ETIOLOGY/PATHOGENESIS 131
CLINICAL ISSUES 131
MICROSCOPIC 131
DIFFERENTIAL DIAGNOSIS 131
DIAGNOSTIC CHECKLIST 131
SELECTED REFERENCES 131
Chapter 43. Trichoadenoma 132
TERMINOLOGY 133
CLINICAL ISSUES 133
MICROSCOPIC 133
DIFFERENTIAL DIAGNOSIS 133
DIAGNOSTIC CHECKLIST 133
SELECTED REFERENCES 133
Chapter 44. Trichoepithelioma 134
TERMINOLOGY 135
ETIOLOGY/PATHOGENESIS 135
CLINICAL ISSUES 135
MACROSCOPIC 135
MICROSCOPIC 135
DIFFERENTIAL DIAGNOSIS 135
SELECTED REFERENCES 135
Chapter 45. Trichoblastoma 138
TERMINOLOGY 139
CLINICAL ISSUES 139
MACROSCOPIC 139
MICROSCOPIC 139
DIFFERENTIAL DIAGNOSIS 139
SELECTED REFERENCES 139
Chapter 46. Panfolliculoma 142
TERMINOLOGY 143
CLINICAL ISSUES 143
MACROSCOPIC 143
MICROSCOPIC 143
DIFFERENTIAL DIAGNOSIS 143
DIAGNOSTIC CHECKLIST 143
SELECTED REFERENCES 143
Chapter 47. Tumor of Follicular Infundibulum 144
TERMINOLOGY 145
ETIOLOGY/PATHOGENESIS 145
CLINICAL ISSUES 145
MICROSCOPIC 145
DIFFERENTIAL DIAGNOSIS 145
SELECTED REFERENCES 145
Chapter 48. Dilated Pore of Winer 146
TERMINOLOGY 147
ETIOLOGY/PATHOGENESIS 147
CLINICAL ISSUES 147
MACROSCOPIC 147
MICROSCOPIC 147
DIFFERENTIAL DIAGNOSIS 147
DIAGNOSTIC CHECKLIST 147
SELECTED REFERENCES 147
Chapter 49. Pilar Sheath Acanthoma 148
TERMINOLOGY 149
ETIOLOGY/PATHOGENESIS 149
CLINICAL ISSUES 149
MACROSCOPIC 149
MICROSCOPIC 149
DIFFERENTIAL DIAGNOSIS 149
DIAGNOSTIC CHECKLIST 149
SELECTED REFERENCES 149
Chapter 50. Inverted Follicular Keratosis 150
TERMINOLOGY 151
ETIOLOGY/PATHOGENESIS 151
CLINICAL ISSUES 151
MICROSCOPIC 151
DIFFERENTIAL DIAGNOSIS 151
DIAGNOSTIC CHECKLIST 151
SELECTED REFERENCES 151
Chapter 51. Tricholemmoma 152
TERMINOLOGY 153
ETIOLOGY/PATHOGENESIS 153
CLINICAL ISSUES 153
MICROSCOPIC 153
DIFFERENTIAL DIAGNOSIS 153
SELECTED REFERENCES 153
Chapter 52. Tricholemmal Carcinoma 156
TERMINOLOGY 157
ETIOLOGY/PATHOGENESIS 157
CLINICAL ISSUES 157
MACROSCOPIC 157
MICROSCOPIC 157
DIFFERENTIAL DIAGNOSIS 157
SELECTED REFERENCES 157
Chapter 53. Pilomatrixoma and Pilomatrical Carcinoma 158
TERMINOLOGY 159
ETIOLOGY/PATHOGENESIS 159
CLINICAL ISSUES 159
MACROSCOPIC 159
MICROSCOPIC 159
ANCILLARY TESTS 160
DIFFERENTIAL DIAGNOSIS 160
DIAGNOSTIC CHECKLIST 160
SELECTED REFERENCES 160
Chapter 54. Fibrofolliculoma and Trichodiscoma 162
TERMINOLOGY 163
ETIOLOGY/PATHOGENESIS 163
CLINICAL ISSUES 163
MICROSCOPIC 163
DIFFERENTIAL DIAGNOSIS 163
SELECTED REFERENCES 163
SECTION 4:\rTumors and Tumor-Like\rConditions With Sebaceous Differentiation 165
Chapter 55. Sebaceous Hyperplasia 166
TERMINOLOGY 167
CLINICAL ISSUES 167
MACROSCOPIC 167
MICROSCOPIC 167
DIFFERENTIAL DIAGNOSIS 167
SELECTED REFERENCES 167
Chapter\r56. Sebaceoma (Sebaceous Epithelioma) 168
TERMINOLOGY 169
ETIOLOGY/PATHOGENESIS 169
CLINICAL ISSUES 169
MICROSCOPIC 169
ANCILLARY TESTS 169
DIFFERENTIAL DIAGNOSIS 169
SELECTED REFERENCES 169
Chapter\r57. Sebaceous Adenoma 172
TERMINOLOGY 173
CLINICAL ISSUES 173
MICROSCOPIC 173
ANCILLARY TESTS 173
DIFFERENTIAL DIAGNOSIS 173
SELECTED REFERENCES 173
Chapter\r58. Sebaceous Carcinoma 174
TERMINOLOGY 175
ETIOLOGY/PATHOGENESIS 175
CLINICAL ISSUES 175
MACROSCOPIC 175
MICROSCOPIC 175
ANCILLARY TESTS 175
DIFFERENTIAL DIAGNOSIS 176
DIAGNOSTIC CHECKLIST 176
SELECTED REFERENCES 176
SECTION 5:\rNeoplasms and Proliferations of Eccrine and\rApocrine Sweat Glands 181
Chapter\r59. Apocrine Tubular Adenoma 182
TERMINOLOGY 183
CLINICAL ISSUES 183
MACROSCOPIC 183
MICROSCOPIC 183
ANCILLARY TESTS 183
DIFFERENTIAL DIAGNOSIS 183
DIAGNOSTIC CHECKLIST 183
SELECTED REFERENCES 183
Chapter\r60. Syringocystadenoma Papilliferum 184
TERMINOLOGY 185
ETIOLOGY/PATHOGENESIS 185
CLINICAL ISSUES 185
MICROSCOPIC 185
ANCILLARY TESTS 185
DIFFERENTIAL DIAGNOSIS 185
DIAGNOSTIC CHECKLIST 185
SELECTED REFERENCES 185
Chapter\r61. Hidradenoma Papilliferum 188
TERMINOLOGY 189
CLINICAL ISSUES 189
MACROSCOPIC 189
MICROSCOPIC 189
DIFFERENTIAL DIAGNOSIS 189
DIAGNOSTIC CHECKLIST 189
SELECTED REFERENCES 189
Chapter\r62. Hidradenoma 190
TERMINOLOGY 191
CLINICAL ISSUES 191
MICROSCOPIC 191
DIFFERENTIAL DIAGNOSIS 191
SELECTED REFERENCES 191
Chapter\r63. Hidradenocarcinoma 194
TERMINOLOGY 195
CLINICAL ISSUES 195
MICROSCOPIC 195
ANCILLARY TESTS 195
DIFFERENTIAL DIAGNOSIS 195
SELECTED REFERENCES 195
Chapter\r64. Poroma and Dermal Duct Tumor 198
TERMINOLOGY 199
ETIOLOGY/PATHOGENESIS 199
CLINICAL ISSUES 199
MACROSCOPIC 199
MICROSCOPIC 199
DIFFERENTIAL DIAGNOSIS 199
SELECTED REFERENCES 199
Chapter\r65. Porocarcinoma 202
TERMINOLOGY 203
ETIOLOGY/PATHOGENESIS 203
CLINICAL ISSUES 203
MACROSCOPIC 203
MICROSCOPIC 203
ANCILLARY TESTS 203
DIFFERENTIAL DIAGNOSIS 203
SELECTED REFERENCES 203
Chapter\r66. Cylindroma 204
TERMINOLOGY 205
ETIOLOGY/PATHOGENESIS 205
CLINICAL ISSUES 205
MICROSCOPIC 205
DIFFERENTIAL DIAGNOSIS 205
SELECTED REFERENCES 205
Chapter\r67. Spiradenoma 208
TERMINOLOGY 209
ETIOLOGY/PATHOGENESIS 209
CLINICAL ISSUES 209
MACROSCOPIC 209
MICROSCOPIC 209
ANCILLARY TESTS 209
DIFFERENTIAL DIAGNOSIS 209
DIAGNOSTIC CHECKLIST 209
SELECTED REFERENCES 209
Chapter\r68. Adenoid Cystic Carcinoma 212
TERMINOLOGY 213
ETIOLOGY/PATHOGENESIS 213
CLINICAL ISSUES 213
MACROSCOPIC 213
MICROSCOPIC 213
ANCILLARY TESTS 213
DIFFERENTIAL DIAGNOSIS 213
SELECTED REFERENCES 213
Chapter\r69. Primary Cutaneous Mucinous Carcinoma 214
TERMINOLOGY 215
CLINICAL ISSUES 215
MACROSCOPIC 215
MICROSCOPIC 215
ANCILLARY TESTS 215
DIFFERENTIAL DIAGNOSIS 215
SELECTED REFERENCES 215
Chapter\r70. Apocrine Carcinoma (Apocrine Adenocarcinoma) 218
TERMINOLOGY 219
CLINICAL ISSUES 219
MICROSCOPIC 219
ANCILLARY TESTS 219
DIFFERENTIAL DIAGNOSIS 219
DIAGNOSTIC CHECKLIST 219
SELECTED REFERENCES 219
Chapter\r71. Digital Papillary Adenocarcinoma 220
TERMINOLOGY 221
CLINICAL ISSUES 221
MACROSCOPIC 221
MICROSCOPIC 221
ANCILLARY TESTS 221
DIFFERENTIAL DIAGNOSIS 221
SELECTED REFERENCES 221
Chapter\r72. Eccrine Hamartomas 224
TERMINOLOGY 225
CLINICAL ISSUES 225
MICROSCOPIC 225
DIFFERENTIAL DIAGNOSIS 225
SELECTED REFERENCES 225
Chapter\r73. Papillary Eccrine Adenoma 226
TERMINOLOGY 227
CLINICAL ISSUES 227
MICROSCOPIC 227
ANCILLARY TESTS 227
DIFFERENTIAL DIAGNOSIS 227
DIAGNOSTIC CHECKLIST 227
SELECTED REFERENCES 227
Chapter\r74. Syringoma 228
TERMINOLOGY 229
ETIOLOGY/PATHOGENESIS 229
CLINICAL ISSUES 229
MICROSCOPIC 229
DIFFERENTIAL DIAGNOSIS 229
SELECTED REFERENCES 229
Chapter\r75. Syringofibroadenoma 230
TERMINOLOGY 231
CLINICAL ISSUES 231
MICROSCOPIC 231
ANCILLARY TESTS 231
DIFFERENTIAL DIAGNOSIS 231
DIAGNOSTIC CHECKLIST 231
SELECTED REFERENCES 231
Chapter\r76. Eccrine Carcinoma 232
TERMINOLOGY 233
CLINICAL ISSUES 233
MICROSCOPIC 233
ANCILLARY TESTS 233
DIFFERENTIAL DIAGNOSIS 233
DIAGNOSTIC CHECKLIST 233
SELECTED REFERENCES 233
Chapter\r77. Squamoid Eccrine Ductal Carcinoma 234
TERMINOLOGY 235
ETIOLOGY/PATHOGENESIS 235
CLINICAL ISSUES 235
MICROSCOPIC 235
ANCILLARY TESTS 235
DIFFERENTIAL DIAGNOSIS 235
SELECTED REFERENCES 235
Chapter\r78. Microcystic Adnexal Carcinoma 236
TERMINOLOGY 237
ETIOLOGY/PATHOGENESIS 237
CLINICAL ISSUES 237
MACROSCOPIC 237
MICROSCOPIC 237
ANCILLARY TESTS 237
DIFFERENTIAL DIAGNOSIS 237
DIAGNOSTIC CHECKLIST 237
SELECTED REFERENCES 237
Chapter\r79. Cutaneous Mixed Tumor (Chondroid Syringoma) 240
TERMINOLOGY 241
CLINICAL ISSUES 241
MACROSCOPIC 241
MICROSCOPIC 241
ANCILLARY TESTS 242
DIFFERENTIAL DIAGNOSIS 242
DIAGNOSTIC CHECKLIST 242
SELECTED REFERENCES 242
Chapter\r80. Malignant Mixed Tumor 244
TERMINOLOGY 245
CLINICAL ISSUES 245
MICROSCOPIC 245
ANCILLARY TESTS 245
DIFFERENTIAL DIAGNOSIS 245
DIAGNOSTIC CHECKLIST 245
SELECTED REFERENCES 245
SECTION 6:\rMetastatic Tumors 247
Chapter\r81. Metastatic Skin Tumors 248
TERMINOLOGY 249
CLINICAL ISSUES 249
MICROSCOPIC 249
DIFFERENTIAL DIAGNOSIS 249
SELECTED REFERENCES 249
Chapter\r82. Metastatic Tumors to Skin 252
ETIOLOGY/PATHOGENESIS 253
CLINICAL ISSUES 253
MICROSCOPIC 253
ANCILLARY TESTS 254
DIFFERENTIAL DIAGNOSIS 254
SELECTED REFERENCES 254
SECTION 7:\rFibrous and “Fibrohistiocytic” Tissue Tumors 258
Benign Fibrous and “Fibrohistiocytic” Tissue Tumors 260
Chapter\r83. Fibroepithelial Polyps (Acrochordons) 260
TERMINOLOGY 261
ETIOLOGY/PATHOGENESIS 261
CLINICAL ISSUES 261
MACROSCOPIC 261
MICROSCOPIC 261
DIFFERENTIAL DIAGNOSIS 261
DIAGNOSTIC CHECKLIST 261
SELECTED REFERENCES 261
Chapter 84. Keloid and Cellular Scar 262
TERMINOLOGY 263
ETIOLOGY/PATHOGENESIS 263
CLINICAL ISSUES 263
MACROSCOPIC 263
MICROSCOPIC 263
DIFFERENTIAL DIAGNOSIS 263
DIAGNOSTIC CHECKLIST 263
SELECTED REFERENCES 263
Chapter 85. Desmoplastic Fibroblastoma 264
TERMINOLOGY 265
CLINICAL ISSUES 265
MACROSCOPIC 265
MICROSCOPIC 265
ANCILLARY TESTS 265
DIFFERENTIAL DIAGNOSIS 265
SELECTED REFERENCES 265
Chapter 86. Pleomorphic Fibroma 266
TERMINOLOGY 267
ETIOLOGY/PATHOGENESIS 267
CLINICAL ISSUES 267
MACROSCOPIC 267
MICROSCOPIC 267
ANCILLARY TESTS 267
DIFFERENTIAL DIAGNOSIS 267
DIAGNOSTIC CHECKLIST 267
SELECTED REFERENCES 267
Chapter 87. Sclerotic Fibroma 268
TERMINOLOGY 269
ETIOLOGY/PATHOGENESIS 269
CLINICAL ISSUES 269
MACROSCOPIC 269
MICROSCOPIC 269
ANCILLARY TESTS 269
DIFFERENTIAL DIAGNOSIS 269
DIAGNOSTIC CHECKLIST 269
SELECTED REFERENCES 269
Chapter 88. Fibromatosis 270
TERMINOLOGY 271
CLINICAL ISSUES 271
MICROSCOPIC 271
ANCILLARY TESTS 271
DIFFERENTIAL DIAGNOSIS 272
SELECTED REFERENCES 272
Chapter 89. Juvenile Hyaline Fibromatosis 276
TERMINOLOGY 277
ETIOLOGY/PATHOGENESIS 277
CLINICAL ISSUES 277
MACROSCOPIC 277
MICROSCOPIC 277
DIFFERENTIAL DIAGNOSIS 277
SELECTED REFERENCES 277
Chapter 90. Angiofibroma and Related Lesions 278
TERMINOLOGY 279
CLINICAL ISSUES 279
MICROSCOPIC 279
ANCILLARY TESTS 279
DIFFERENTIAL DIAGNOSIS 279
DIAGNOSTIC CHECKLIST 279
SELECTED REFERENCES 279
Chapter 91. Acral Fibrokeratoma 280
TERMINOLOGY 281
ETIOLOGY/PATHOGENESIS 281
CLINICAL ISSUES 281
MICROSCOPIC 281
ANCILLARY TESTS 281
DIFFERENTIAL DIAGNOSIS 281
DIAGNOSTIC CHECKLIST 281
SELECTED REFERENCES 281
Chapter 92. Dermatofibroma and Fibrous Histiocytoma 282
TERMINOLOGY 283
ETIOLOGY/PATHOGENESIS 283
CLINICAL ISSUES 283
MACROSCOPIC 283
MICROSCOPIC 283
ANCILLARY TESTS 284
DIFFERENTIAL DIAGNOSIS 284
DIAGNOSTIC CHECKLIST 284
SELECTED REFERENCES 284
Chapter 93. Epithelioid Cell Histiocytoma 288
TERMINOLOGY 289
ETIOLOGY/PATHOGENESIS 289
CLINICAL ISSUES 289
MACROSCOPIC 289
MICROSCOPIC 289
ANCILLARY TESTS 289
DIFFERENTIAL DIAGNOSIS 289
SELECTED REFERENCES 289
Chapter 94. Dermatomyofibroma 290
TERMINOLOGY 291
ETIOLOGY/PATHOGENESIS 291
CLINICAL ISSUES 291
MACROSCOPIC 291
MICROSCOPIC 291
ANCILLARY TESTS 291
DIFFERENTIAL DIAGNOSIS 291
DIAGNOSTIC CHECKLIST 291
SELECTED REFERENCES 291
Chapter 95. Fibrous Hamartoma of Infancy 292
TERMINOLOGY 293
ETIOLOGY/PATHOGENESIS 293
CLINICAL ISSUES 293
IMAGING 293
MACROSCOPIC 293
MICROSCOPIC 293
ANCILLARY TESTS 293
DIFFERENTIAL DIAGNOSIS 294
SELECTED REFERENCES 294
Chapter 96. Digital Fibromatosis (Infantile Digital Fibromatosis) 298
TERMINOLOGY 299
CLINICAL ISSUES 299
MACROSCOPIC 299
MICROSCOPIC 299
ANCILLARY TESTS 299
DIFFERENTIAL DIAGNOSIS 299
DIAGNOSTIC CHECKLIST 300
SELECTED REFERENCES 300
Chapter 97. Angiomyofibroblastoma 302
TERMINOLOGY 303
CLINICAL ISSUES 303
MACROSCOPIC 303
MICROSCOPIC 303
ANCILLARY TESTS 303
DIFFERENTIAL DIAGNOSIS 303
SELECTED REFERENCES 303
Chapter 98. Multinucleate Cell Angiohistiocytoma 306
TERMINOLOGY 307
ETIOLOGY/PATHOGENESIS 307
CLINICAL ISSUES 307
MACROSCOPIC 307
MICROSCOPIC 307
ANCILLARY TESTS 307
DIFFERENTIAL DIAGNOSIS 307
DIAGNOSTIC CHECKLIST 307
SELECTED REFERENCES 307
Chapter 99. Giant Cell Tumor of Tendon Sheath 308
TERMINOLOGY 309
ETIOLOGY/PATHOGENESIS 309
CLINICAL ISSUES 309
IMAGING 309
MACROSCOPIC 309
MICROSCOPIC 309
ANCILLARY TESTS 310
DIFFERENTIAL DIAGNOSIS 310
SELECTED REFERENCES 310
Chapter 100. Myofibroma and Myofibromatosis 314
TERMINOLOGY 315
CLINICAL ISSUES 315
MICROSCOPIC 315
ANCILLARY TESTS 315
DIFFERENTIAL DIAGNOSIS 315
SELECTED REFERENCES 315
Chapter 101. Cutaneous Myxoma and Angiomyxoma 320
TERMINOLOGY 321
ETIOLOGY/PATHOGENESIS 321
CLINICAL ISSUES 321
MICROSCOPIC 321
DIFFERENTIAL DIAGNOSIS 321
DIAGNOSTIC CHECKLIST 321
SELECTED REFERENCES 321
Chapter 102. Superficial Acral Fibromyxoma 322
TERMINOLOGY 323
CLINICAL ISSUES 323
MACROSCOPIC 323
MICROSCOPIC 323
ANCILLARY TESTS 323
DIFFERENTIAL DIAGNOSIS 323
SELECTED REFERENCES 323
Chapter 103. Distinctive Dermal Clear Cell Mesenchymal Tumor 324
TERMINOLOGY 325
ETIOLOGY/PATHOGENESIS 325
CLINICAL ISSUES 325
MACROSCOPIC 325
MICROSCOPIC 325
ANCILLARY TESTS 325
DIFFERENTIAL DIAGNOSIS 325
DIAGNOSTIC CHECKLIST 325
SELECTED REFERENCES 325
Chapter 104. Pseudosarcomatous Fibroblastic Proliferations 326
TERMINOLOGY 327
CLINICAL ISSUES 327
IMAGING 327
MACROSCOPIC 327
MICROSCOPIC 327
DIFFERENTIAL DIAGNOSIS 328
SELECTED REFERENCES 328
Atypical and Malignant Fibrous and “Fibrohistiocytic” Tissue Tumors 334
Chapter 105. Angiomatoid Fibrous Histiocytoma 334
TERMINOLOGY 335
ETIOLOGY/PATHOGENESIS 335
CLINICAL ISSUES 335
MACROSCOPIC 335
MICROSCOPIC 335
ANCILLARY TESTS 335
DIFFERENTIAL DIAGNOSIS 336
SELECTED REFERENCES 336
Chapter 106. Plexiform Fibrohistiocytic Tumor 342
TERMINOLOGY 343
CLINICAL ISSUES 343
MACROSCOPIC 343
MICROSCOPIC 343
ANCILLARY TESTS 343
DIFFERENTIAL DIAGNOSIS 343
SELECTED REFERENCES 343
Chapter 107. Dermatofibrosarcoma Protuberans 346
TERMINOLOGY 347
ETIOLOGY/PATHOGENESIS 347
CLINICAL ISSUES 347
MACROSCOPIC 347
MICROSCOPIC 347
ANCILLARY TESTS 347
DIFFERENTIAL DIAGNOSIS 348
DIAGNOSTIC CHECKLIST 348
SELECTED REFERENCES 348
Chapter 108. Atypical Fibroxanthoma 352
TERMINOLOGY 353
ETIOLOGY/PATHOGENESIS 353
CLINICAL ISSUES 353
MACROSCOPIC 353
MICROSCOPIC 353
ANCILLARY TESTS 353
DIFFERENTIAL DIAGNOSIS 353
DIAGNOSTIC CHECKLIST 354
SELECTED REFERENCES 354
Chapter 109. Pleomorphic Dermal Sarcoma 358
TERMINOLOGY 359
ETIOLOGY/PATHOGENESIS 359
CLINICAL ISSUES 359
MACROSCOPIC 359
MICROSCOPIC 359
ANCILLARY TESTS 359
DIFFERENTIAL DIAGNOSIS 359
SELECTED REFERENCES 359
Chapter 110. Adult-Type Fibrosarcoma 360
TERMINOLOGY 361
CLINICAL ISSUES 361
MACROSCOPIC 361
MICROSCOPIC 361
ANCILLARY TESTS 361
DIFFERENTIAL DIAGNOSIS 361
SELECTED REFERENCES 361
Chapter 111. Myxofibrosarcoma 362
TERMINOLOGY 363
CLINICAL ISSUES 363
MACROSCOPIC 363
MICROSCOPIC 363
DIFFERENTIAL DIAGNOSIS 363
DIAGNOSTIC CHECKLIST 363
SELECTED REFERENCES 363
Chapter 112. Superficial Low-Grade Fibromyxoid Sarcoma 366
TERMINOLOGY 367
CLINICAL ISSUES 367
MACROSCOPIC 367
MICROSCOPIC 367
ANCILLARY TESTS 367
DIFFERENTIAL DIAGNOSIS 367
SELECTED REFERENCES 367
Chapter 113. Myxoinflammatory Fibroblastic Sarcoma 368
TERMINOLOGY 369
CLINICAL ISSUES 369
MACROSCOPIC 369
MICROSCOPIC 369
ANCILLARY TESTS 369
DIFFERENTIAL DIAGNOSIS 369
SELECTED REFERENCES 370
Chapter 114. Epithelioid Sarcoma 374
TERMINOLOGY 375
CLINICAL ISSUES 375
MACROSCOPIC 375
MICROSCOPIC 375
ANCILLARY TESTS 376
DIFFERENTIAL DIAGNOSIS 376
SELECTED REFERENCES 376
SECTION 8:\rVascular and Perivascular Tumors\rand Pseudotumors 381
Chapter 115. Vascular Hamartomas 382
TERMINOLOGY 383
ETIOLOGY/PATHOGENESIS 383
CLINICAL ISSUES 383
MICROSCOPIC 383
DIFFERENTIAL DIAGNOSIS 383
SELECTED REFERENCES 383
Chapter\r116. Arteriovenous Hemangioma (Malformation) 384
TERMINOLOGY 385
CLINICAL ISSUES 385
MACROSCOPIC 385
MICROSCOPIC 385
DIFFERENTIAL DIAGNOSIS 385
SELECTED REFERENCES 385
Chapter\r117. Capillary, Venous, and Cavernous Hemangiomas 386
TERMINOLOGY 387
ETIOLOGY/PATHOGENESIS 387
CLINICAL ISSUES 387
IMAGING 387
MACROSCOPIC 387
MICROSCOPIC 387
ANCILLARY TESTS 388
DIFFERENTIAL DIAGNOSIS 388
DIAGNOSTIC CHECKLIST 388
SELECTED REFERENCES 388
Chapter\r118. Infantile (Juvenile) Hemangioma 392
TERMINOLOGY 393
CLINICAL ISSUES 393
MACROSCOPIC 393
MICROSCOPIC 393
ANCILLARY TESTS 393
DIFFERENTIAL DIAGNOSIS 394
DIAGNOSTIC CHECKLIST 394
SELECTED REFERENCES 394
Chapter\r119. Sinusoidal Hemangioma 398
TERMINOLOGY 399
ETIOLOGY/PATHOGENESIS 399
CLINICAL ISSUES 399
MACROSCOPIC 399
MICROSCOPIC 399
DIFFERENTIAL DIAGNOSIS 399
DIAGNOSTIC CHECKLIST 399
SELECTED REFERENCES 399
Chapter\r120. Tufted Angioma 400
TERMINOLOGY 401
ETIOLOGY/PATHOGENESIS 401
CLINICAL ISSUES 401
MACROSCOPIC 401
MICROSCOPIC 401
DIFFERENTIAL DIAGNOSIS 401
DIAGNOSTIC CHECKLIST 401
SELECTED REFERENCES 401
Chapter\r121. Glomeruloid Hemangioma 402
TERMINOLOGY 403
ETIOLOGY/PATHOGENESIS 403
CLINICAL ISSUES 403
MACROSCOPIC 403
MICROSCOPIC 403
DIFFERENTIAL DIAGNOSIS 403
DIAGNOSTIC CHECKLIST 403
SELECTED REFERENCES 403
Chapter\r122. Angiolymphoid Hyperplasia With Eosinophilia 404
TERMINOLOGY 405
ETIOLOGY/PATHOGENESIS 405
CLINICAL ISSUES 405
MACROSCOPIC 405
MICROSCOPIC 405
ANCILLARY TESTS 405
DIFFERENTIAL DIAGNOSIS 405
SELECTED REFERENCES 405
Chapter\r123. Hobnail (Targetoid Hemosiderotic) Hemangioma 406
TERMINOLOGY 407
ETIOLOGY/PATHOGENESIS 407
CLINICAL ISSUES 407
MACROSCOPIC 407
MICROSCOPIC 407
DIFFERENTIAL DIAGNOSIS 407
DIAGNOSTIC CHECKLIST 407
SELECTED REFERENCES 407
Chapter\r124. Spindle Cell Hemangioma 408
TERMINOLOGY 409
ETIOLOGY/PATHOGENESIS 409
CLINICAL ISSUES 409
MICROSCOPIC 409
ANCILLARY TESTS 409
DIFFERENTIAL DIAGNOSIS 409
DIAGNOSTIC CHECKLIST 409
SELECTED REFERENCES 409
Chapter\r125. Microvenular Hemangioma 410
TERMINOLOGY 411
ETIOLOGY/PATHOGENESIS 411
CLINICAL ISSUES 411
MACROSCOPIC 411
DIFFERENTIAL DIAGNOSIS 411
DIAGNOSTIC CHECKLIST 411
SELECTED REFERENCES 411
Chapter\r126. Verrucous Hemangioma 412
TERMINOLOGY 413
ETIOLOGY/PATHOGENESIS 413
CLINICAL ISSUES 413
MICROSCOPIC 413
ANCILLARY TESTS 413
DIFFERENTIAL DIAGNOSIS 413
DIAGNOSTIC CHECKLIST 413
SELECTED REFERENCES 413
Chapter\r127. Angiokeratoma 414
TERMINOLOGY 415
CLINICAL ISSUES 415
MACROSCOPIC 415
MICROSCOPIC 415
DIFFERENTIAL DIAGNOSIS 415
DIAGNOSTIC CHECKLIST 415
SELECTED REFERENCES 415
Chapter\r128. Venous Lake 416
TERMINOLOGY 417
ETIOLOGY/PATHOGENESIS 417
CLINICAL ISSUES 417
MICROSCOPIC 417
DIFFERENTIAL DIAGNOSIS 417
DIAGNOSTIC CHECKLIST 417
SELECTED REFERENCES 417
Chapter\r129. Papillary Endothelial Hyperplasia (Masson Tumor) 418
TERMINOLOGY 419
ETIOLOGY/PATHOGENESIS 419
CLINICAL ISSUES 419
MACROSCOPIC 419
MICROSCOPIC 419
ANCILLARY TESTS 419
DIFFERENTIAL DIAGNOSIS 419
DIAGNOSTIC CHECKLIST 419
SELECTED REFERENCES 419
Chapter\r130. Glomus Tumors 422
TERMINOLOGY 423
ETIOLOGY/PATHOGENESIS 423
CLINICAL ISSUES 423
MACROSCOPIC 423
MICROSCOPIC 423
ANCILLARY TESTS 424
DIFFERENTIAL DIAGNOSIS 424
SELECTED REFERENCES 424
Chapter\r131. Lymphangioma and Superficial Lymphangioma 428
TERMINOLOGY 429
ETIOLOGY/PATHOGENESIS 429
CLINICAL ISSUES 429
IMAGING 429
MACROSCOPIC 429
MICROSCOPIC 430
ANCILLARY TESTS 430
DIFFERENTIAL DIAGNOSIS 430
DIAGNOSTIC CHECKLIST 430
SELECTED REFERENCES 430
Chapter\r132. Progressive Lymphangioma 432
TERMINOLOGY 433
ETIOLOGY/PATHOGENESIS 433
CLINICAL ISSUES 433
MACROSCOPIC 433
MICROSCOPIC 433
ANCILLARY TESTS 433
DIFFERENTIAL DIAGNOSIS 433
DIAGNOSTIC CHECKLIST 433
SELECTED REFERENCES 433
Chapter\r133. Bacillary Angiomatosis 434
TERMINOLOGY 435
ETIOLOGY/PATHOGENESIS 435
CLINICAL ISSUES 435
MACROSCOPIC 435
MICROSCOPIC 435
ANCILLARY TESTS 435
DIFFERENTIAL DIAGNOSIS 435
DIAGNOSTIC CHECKLIST 435
SELECTED REFERENCES 435
Chapter\r134. PEComas 436
TERMINOLOGY 437
ETIOLOGY/PATHOGENESIS 437
CLINICAL ISSUES 437
MICROSCOPIC 437
ANCILLARY TESTS 437
DIFFERENTIAL DIAGNOSIS 437
SELECTED REFERENCES 438
Chapter\r135. Kaposi Sarcoma 442
TERMINOLOGY 443
ETIOLOGY/PATHOGENESIS 443
CLINICAL ISSUES 443
MICROSCOPIC 443
ANCILLARY TESTS 444
DIFFERENTIAL DIAGNOSIS 444
SELECTED REFERENCES 444
Chapter\r136. Kaposiform Hemangioendothelioma 450
ETIOLOGY/PATHOGENESIS 451
CLINICAL ISSUES 451
MICROSCOPIC 451
ANCILLARY TESTS 451
DIFFERENTIAL DIAGNOSIS 451
DIAGNOSTIC CHECKLIST 451
SELECTED REFERENCES 451
Chapter\r137. Epithelioid Hemangioendothelioma 452
TERMINOLOGY 453
CLINICAL ISSUES 453
MACROSCOPIC 453
MICROSCOPIC 453
ANCILLARY TESTS 453
DIFFERENTIAL DIAGNOSIS 454
DIAGNOSTIC CHECKLIST 454
SELECTED REFERENCES 454
Chapter\r138. Retiform Hemangioendothelioma 456
TERMINOLOGY 457
ETIOLOGY/PATHOGENESIS 457
CLINICAL ISSUES 457
MACROSCOPIC 457
MICROSCOPIC 457
ANCILLARY TESTS 457
DIFFERENTIAL DIAGNOSIS 457
DIAGNOSTIC CHECKLIST 457
SELECTED REFERENCES 457
Chapter\r139. Papillary Intralymphatic Angioendothelioma (Dabska Tumor) 458
TERMINOLOGY 459
ETIOLOGY/PATHOGENESIS 459
CLINICAL ISSUES 459
MACROSCOPIC 459
MICROSCOPIC 459
ANCILLARY TESTS 459
DIFFERENTIAL DIAGNOSIS 459
DIAGNOSTIC CHECKLIST 459
SELECTED REFERENCES 459
Chapter\r140. Atypical Vascular Lesion 460
TERMINOLOGY 461
ETIOLOGY/PATHOGENESIS 461
CLINICAL ISSUES 461
MICROSCOPIC 461
DIFFERENTIAL DIAGNOSIS 461
DIAGNOSTIC CHECKLIST 461
SELECTED REFERENCES 461
Chapter\r141. Angiosarcoma 462
TERMINOLOGY 463
ETIOLOGY/PATHOGENESIS 463
CLINICAL ISSUES 463
MACROSCOPIC 463
MICROSCOPIC 463
ANCILLARY TESTS 464
DIFFERENTIAL DIAGNOSIS 464
SELECTED REFERENCES 464
SECTION 9: Tumors and Tumor-Like Conditions With Neural, Nerve Sheath, and Neuroendocrine Differentiation 469
Chapter\r142. Neuromas 470
TERMINOLOGY 471
ETIOLOGY/PATHOGENESIS 471
CLINICAL ISSUES 471
MACROSCOPIC 471
MICROSCOPIC 471
ANCILLARY TESTS 472
DIFFERENTIAL DIAGNOSIS 472
DIAGNOSTIC CHECKLIST 472
SELECTED REFERENCES 472
Chapter\r143. Neurofibroma 474
TERMINOLOGY 475
ETIOLOGY/PATHOGENESIS 475
CLINICAL ISSUES 475
MACROSCOPIC 475
MICROSCOPIC 475
ANCILLARY TESTS 476
DIFFERENTIAL DIAGNOSIS 476
SELECTED REFERENCES 476
Chapter\r144. Schwannoma 482
TERMINOLOGY 483
ETIOLOGY/PATHOGENESIS 483
CLINICAL ISSUES 483
MACROSCOPIC 483
MICROSCOPIC 483
ANCILLARY TESTS 484
DIFFERENTIAL DIAGNOSIS 484
SELECTED REFERENCES 485
Chapter\r145. Cellular Neurothekeoma 496
TERMINOLOGY 497
CLINICAL ISSUES 497
MACROSCOPIC 497
MICROSCOPIC 497
ANCILLARY TESTS 497
DIFFERENTIAL DIAGNOSIS 497
SELECTED REFERENCES 497
Chapter\r146. Dermal Nerve Sheath Myxoma 500
TERMINOLOGY 501
CLINICAL ISSUES 501
MACROSCOPIC 501
MICROSCOPIC 501
ANCILLARY TESTS 501
DIFFERENTIAL DIAGNOSIS 501
SELECTED REFERENCES 501
Chapter\r147. Granular Cell Tumor 504
TERMINOLOGY 505
CLINICAL ISSUES 505
MACROSCOPIC 505
MICROSCOPIC 505
ANCILLARY TESTS 505
DIFFERENTIAL DIAGNOSIS 506
DIAGNOSTIC CHECKLIST 506
SELECTED REFERENCES 506
Chapter\r148.Lipomatosis of Nerve 510
TERMINOLOGY 511
CLINICAL ISSUES 511
IMAGING 511
MACROSCOPIC 511
MICROSCOPIC 511
DIFFERENTIAL DIAGNOSIS 511
SELECTED REFERENCES 511
Chapter\r149. Perineurioma 512
TERMINOLOGY 513
ETIOLOGY/PATHOGENESIS 513
CLINICAL ISSUES 513
MACROSCOPIC 513
MICROSCOPIC 513
ANCILLARY TESTS 513
DIFFERENTIAL DIAGNOSIS 514
SELECTED REFERENCES 514
Chapter\r150. Nasal Glial Heterotopia 516
TERMINOLOGY 517
ETIOLOGY/PATHOGENESIS 517
CLINICAL ISSUES 517
IMAGING 517
MACROSCOPIC 517
MICROSCOPIC 517
ANCILLARY TESTS 517
DIFFERENTIAL DIAGNOSIS 517
SELECTED REFERENCES 517
Chapter\r151. Ectopic Meningioma 518
TERMINOLOGY 519
ETIOLOGY/PATHOGENESIS 519
CLINICAL ISSUES 519
MACROSCOPIC 519
MICROSCOPIC 519
ANCILLARY TESTS 519
DIFFERENTIAL DIAGNOSIS 519
SELECTED REFERENCES 519
Chapter\r152. Superficial Malignant Peripheral Nerve Sheath Tumor 520
TERMINOLOGY 521
ETIOLOGY/PATHOGENESIS 521
CLINICAL ISSUES 521
IMAGING 521
MACROSCOPIC 521
MICROSCOPIC 521
ANCILLARY TESTS 522
DIFFERENTIAL DIAGNOSIS 522
SELECTED REFERENCES 522
Chapter\r153. Superficial Ewing Sarcoma/Primitive Neuroectodermal Tumor 524
TERMINOLOGY 525
ETIOLOGY/PATHOGENESIS 525
CLINICAL ISSUES 525
MACROSCOPIC 525
MICROSCOPIC 525
ANCILLARY TESTS 525
DIFFERENTIAL DIAGNOSIS 526
DIAGNOSTIC CHECKLIST 526
SELECTED REFERENCES 526
Chapter\r154. Primary Neuroendocrine (Merkel Cell) Carcinoma 528
TERMINOLOGY 529
ETIOLOGY/PATHOGENESIS 529
CLINICAL ISSUES 529
MACROSCOPIC 529
MICROSCOPIC 529
ANCILLARY TESTS 530
DIFFERENTIAL DIAGNOSIS 530
DIAGNOSTIC CHECKLIST 530
SELECTED REFERENCES 530
SECTION 10: Tumors of Muscle, Fat, Cartilage, and Bone 533
Chapter\r155. Congenital Smooth Muscle Hamartoma 534
TERMINOLOGY 535
CLINICAL ISSUES 535
MACROSCOPIC 535
MICROSCOPIC 535
DIFFERENTIAL DIAGNOSIS 535
DIAGNOSTIC CHECKLIST 535
SELECTED REFERENCES 535
Chapter\r156. Leiomyoma (Pilar) 536
TERMINOLOGY 537
ETIOLOGY/PATHOGENESIS 537
CLINICAL ISSUES 537
MICROSCOPIC 537
ANCILLARY TESTS 537
DIFFERENTIAL DIAGNOSIS 537
SELECTED REFERENCES 537
Chapter\r157. Angioleiomyoma 540
TERMINOLOGY 541
CLINICAL ISSUES 541
MACROSCOPIC 541
MICROSCOPIC 541
ANCILLARY TESTS 541
DIFFERENTIAL DIAGNOSIS 541
SELECTED REFERENCES 541
Chapter\r158. Leiomyosarcoma 542
TERMINOLOGY 543
ETIOLOGY/PATHOGENESIS 543
CLINICAL ISSUES 543
MICROSCOPIC 543
ANCILLARY TESTS 544
DIFFERENTIAL DIAGNOSIS 544
DIAGNOSTIC CHECKLIST 544
SELECTED REFERENCES 544
Chapter\r159. Rhabdomyoma 548
TERMINOLOGY 549
ETIOLOGY/PATHOGENESIS 549
CLINICAL ISSUES 549
MACROSCOPIC 549
MICROSCOPIC 549
ANCILLARY TESTS 549
DIFFERENTIAL DIAGNOSIS 549
SELECTED REFERENCES 549
Chapter\r160. Cutaneous Rhabdomyosarcoma 552
TERMINOLOGY 553
CLINICAL ISSUES 553
MACROSCOPIC 553
MICROSCOPIC 553
ANCILLARY TESTS 553
DIFFERENTIAL DIAGNOSIS 554
SELECTED REFERENCES 554
Chapter\r161. Lipoma 556
TERMINOLOGY 557
CLINICAL ISSUES 557
MACROSCOPIC 557
MICROSCOPIC 557
ANCILLARY TESTS 558
DIFFERENTIAL DIAGNOSIS 558
DIAGNOSTIC CHECKLIST 558
SELECTED REFERENCES 558
Chapter\r162. Angiolipoma 562
TERMINOLOGY 563
ETIOLOGY/PATHOGENESIS 563
CLINICAL ISSUES 563
MACROSCOPIC 563
MICROSCOPIC 563
ANCILLARY TESTS 563
DIFFERENTIAL DIAGNOSIS 563
DIAGNOSTIC CHECKLIST 563
SELECTED REFERENCES 563
Chapter\r163. Spindle Cell/Pleomorphic Lipoma 566
TERMINOLOGY 567
CLINICAL ISSUES 567
MACROSCOPIC 567
MICROSCOPIC 567
ANCILLARY TESTS 567
DIFFERENTIAL DIAGNOSIS 567
SELECTED REFERENCES 568
Chapter\r164. Chondroid Lipoma 572
TERMINOLOGY 573
CLINICAL ISSUES 573
MACROSCOPIC 573
MICROSCOPIC 573
ANCILLARY TESTS 573
DIFFERENTIAL DIAGNOSIS 573
SELECTED REFERENCES 573
Chapter\r165. Nevus Lipomatosus 576
TERMINOLOGY 577
ETIOLOGY/PATHOGENESIS 577
CLINICAL ISSUES 577
MACROSCOPIC 577
MICROSCOPIC 577
DIFFERENTIAL DIAGNOSIS 577
SELECTED REFERENCES 577
Chapter\r166.Hibernoma 578
TERMINOLOGY 579
CLINICAL ISSUES 579
MACROSCOPIC 579
MICROSCOPIC 579
ANCILLARY TESTS 579
DIFFERENTIAL DIAGNOSIS 579
SELECTED REFERENCES 579
Chapter\r167 Atypical Lipomatous Tumor and Liposarcoma 580
TERMINOLOGY 581
CLINICAL ISSUES 581
IMAGING 581
MACROSCOPIC 581
MICROSCOPIC 581
ANCILLARY TESTS 581
DIFFERENTIAL DIAGNOSIS 581
DIAGNOSTIC CHECKLIST 582
SELECTED REFERENCES 582
Chapter\r168. Soft Tissue Chondroma 588
TERMINOLOGY 589
ETIOLOGY/PATHOGENESIS 589
CLINICAL ISSUES 589
IMAGING 589
MACROSCOPIC 589
MICROSCOPIC 589
ANCILLARY TESTS 589
DIFFERENTIAL DIAGNOSIS 589
DIAGNOSTIC CHECKLIST 590
SELECTED REFERENCES 590
Chapter\r169. Osteoma Cutis 594
TERMINOLOGY 595
ETIOLOGY/PATHOGENESIS 595
CLINICAL ISSUES 595
MACROSCOPIC 595
MICROSCOPIC 595
DIFFERENTIAL DIAGNOSIS 595
SELECTED REFERENCES 595
SECTION 11:\rHistiocytic Proliferations 597
Chapter\r170. Juvenile and Adult-Type Xanthogranuloma 598
TERMINOLOGY 599
CLINICAL ISSUES 599
MICROSCOPIC 599
ANCILLARY TESTS 599
DIFFERENTIAL DIAGNOSIS 599
SELECTED REFERENCES 599
Chapter\r171. Reticulohistiocytoma 602
TERMINOLOGY 603
ETIOLOGY/PATHOGENESIS 603
CLINICAL ISSUES 603
MACROSCOPIC 603
MICROSCOPIC 603
ANCILLARY TESTS 603
DIFFERENTIAL DIAGNOSIS 604
DIAGNOSTIC CHECKLIST 604
SELECTED REFERENCES 604
Chapter\r172. Multicentric Reticulohistiocytosis 606
TERMINOLOGY 607
ETIOLOGY/PATHOGENESIS 607
CLINICAL ISSUES 607
MACROSCOPIC 607
MICROSCOPIC 607
ANCILLARY TESTS 607
DIFFERENTIAL DIAGNOSIS 607
DIAGNOSTIC CHECKLIST 607
SELECTED REFERENCES 607
Chapter\r173. Langerhans Cell Histiocytosis 608
TERMINOLOGY 609
CLINICAL ISSUES 609
MICROSCOPIC 609
ANCILLARY TESTS 609
DIFFERENTIAL DIAGNOSIS 609
SELECTED REFERENCES 609
Chapter\r174. Non-Langerhans Cell Histiocytoses 612
TERMINOLOGY 613
ETIOLOGY/PATHOGENESIS 613
CLINICAL ISSUES 613
MICROSCOPIC 613
ANCILLARY TESTS 613
DIFFERENTIAL DIAGNOSIS 613
SELECTED REFERENCES 615
Chapter\r175. Rosai-Dorfman Disease 620
TERMINOLOGY 621
ETIOLOGY/PATHOGENESIS 621
CLINICAL ISSUES 621
MACROSCOPIC 621
MICROSCOPIC 621
DIFFERENTIAL DIAGNOSIS 621
SELECTED REFERENCES 622
Chapter\r176. Histiocytic Sarcoma 626
TERMINOLOGY 627
ETIOLOGY/PATHOGENESIS 627
CLINICAL ISSUES 627
MACROSCOPIC 627
MICROSCOPIC 627
ANCILLARY TESTS 627
DIFFERENTIAL DIAGNOSIS 628
SELECTED REFERENCES 628
Chapter\r177. Polyvinylpyrrolidone Storage Disease 632
TERMINOLOGY 633
ETIOLOGY/PATHOGENESIS 633
CLINICAL ISSUES 633
MICROSCOPIC 633
ANCILLARY TESTS 633
DIFFERENTIAL DIAGNOSIS 633
DIAGNOSTIC CHECKLIST 633
SELECTED REFERENCES 633
Chapter\r178. Xanthomas 634
TERMINOLOGY 635
ETIOLOGY/PATHOGENESIS 635
CLINICAL ISSUES 635
MACROSCOPIC 635
MICROSCOPIC 635
ANCILLARY TESTS 635
DIFFERENTIAL DIAGNOSIS 636
SELECTED REFERENCES 636
Chapter\r179. Verruciform Xanthoma 638
TERMINOLOGY 639
CLINICAL ISSUES 639
MICROSCOPIC 639
ANCILLARY TESTS 639
DIFFERENTIAL DIAGNOSIS 639
SELECTED REFERENCES 639
SECTION 12:\rLymphomas and Hematopoietic Proliferations 641
B-Cell Neoplasms 641
Chapter\r180. Cutaneous Plasmacytoma 642
TERMINOLOGY 643
ETIOLOGY/PATHOGENESIS 643
CLINICAL ISSUES 643
MACROSCOPIC 643
MICROSCOPIC 643
ANCILLARY TESTS 643
DIFFERENTIAL DIAGNOSIS 644
SELECTED REFERENCES 644
Chapter\r181. Primary Cutaneous Marginal Zone Lymphoma 646
TERMINOLOGY 647
ETIOLOGY/PATHOGENESIS 647
CLINICAL ISSUES 647
MACROSCOPIC 647
MICROSCOPIC 647
ANCILLARY TESTS 647
DIFFERENTIAL DIAGNOSIS 648
SELECTED REFERENCES 648
Chapter\r182. Primary Cutaneous Follicle Center Lymphoma 652
TERMINOLOGY 653
ETIOLOGY/PATHOGENESIS 653
CLINICAL ISSUES 653
MACROSCOPIC 653
MICROSCOPIC 653
ANCILLARY TESTS 654
DIFFERENTIAL DIAGNOSIS 654
DIAGNOSTIC CHECKLIST 655
SELECTED REFERENCES 655
Chapter\r183. Diffuse Large B-Cell Lymphoma, Leg Type 658
TERMINOLOGY 659
ETIOLOGY/PATHOGENESIS 659
CLINICAL ISSUES 659
MICROSCOPIC 659
ANCILLARY TESTS 659
DIFFERENTIAL DIAGNOSIS 660
DIAGNOSTIC CHECKLIST 660
SELECTED REFERENCES 660
Chapter\r184. Lymphomatoid Granulomatosis 666
TERMINOLOGY 667
ETIOLOGY/PATHOGENESIS 667
CLINICAL ISSUES 667
MICROSCOPIC 667
ANCILLARY TESTS 667
DIFFERENTIAL DIAGNOSIS 667
SELECTED REFERENCES 667
Chapter\r185. Systemic B-Cell Lymphomas Involving Skin 670
TERMINOLOGY 671
ETIOLOGY/PATHOGENESIS 671
CLINICAL ISSUES 671
MICROSCOPIC 671
ANCILLARY TESTS 672
DIFFERENTIAL DIAGNOSIS 672
SELECTED REFERENCES 672
Chapter\r186. Intravascular Large B-Cell Lymphoma 676
TERMINOLOGY 677
CLINICAL ISSUES 677
MICROSCOPIC 677
ANCILLARY TESTS 678
DIFFERENTIAL DIAGNOSIS 678
DIAGNOSTIC CHECKLIST 678
SELECTED REFERENCES 678
T-Cell and NK-Cell Neoplasms 680
Chapter\r187. Mycosis Fungoides (and Subtypes) 680
TERMINOLOGY 681
ETIOLOGY/PATHOGENESIS 681
CLINICAL ISSUES 681
MACROSCOPIC 682
MICROSCOPIC 682
ANCILLARY TESTS 682
DIFFERENTIAL DIAGNOSIS 683
SELECTED REFERENCES 683
Chapter\r188. Adult T-Cell Leukemia/Lymphoma 692
TERMINOLOGY 693
ETIOLOGY/PATHOGENESIS 693
CLINICAL ISSUES 693
IMAGING 693
MICROSCOPIC 693
ANCILLARY TESTS 694
DIFFERENTIAL DIAGNOSIS 694
SELECTED REFERENCES 694
Chapter\r189. Subcutaneous Panniculitis-Like T-Cell Lymphoma 696
TERMINOLOGY 697
ETIOLOGY/PATHOGENESIS 697
CLINICAL ISSUES 697
IMAGING 697
MICROSCOPIC 697
ANCILLARY TESTS 697
DIFFERENTIAL DIAGNOSIS 698
SELECTED REFERENCES 698
Chapter\r190. Extranodal NK-/T-Cell Lymphoma, Nasal Type 702
TERMINOLOGY 703
ETIOLOGY/PATHOGENESIS 703
CLINICAL ISSUES 703
IMAGING 703
MACROSCOPIC 703
MICROSCOPIC 703
ANCILLARY TESTS 703
DIFFERENTIAL DIAGNOSIS 704
SELECTED REFERENCES 704
Chapter\r191. Lymphomatoid Papulosis 708
TERMINOLOGY 709
ETIOLOGY/PATHOGENESIS 709
CLINICAL ISSUES 709
MICROSCOPIC 709
ANCILLARY TESTS 709
DIFFERENTIAL DIAGNOSIS 710
SELECTED REFERENCES 710
Chapter\r192. Primary Cutaneous Anaplastic Large Cell Lymphoma 714
TERMINOLOGY 715
TIOLOGY/PATHOGENESIS 715
CLINICAL ISSUES 715
MICROSCOPIC 715
ANCILLARY TESTS 715
DIFFERENTIAL DIAGNOSIS 716
SELECTED REFERENCES 716
Chapter\r193. Aggressive Epidermotropic CD8(+) Cytotoxic T-Cell Lymphoma 720
TERMINOLOGY 721
CLINICAL ISSUES 721
MICROSCOPIC 721
ANCILLARY TESTS 721
DIFFERENTIAL DIAGNOSIS 721
SELECTED REFERENCES 721
Chapter\r194. Primary Cutaneous CD4(+) Small/Medium Pleomorphic T-Cell Lymphoma 724
TERMINOLOGY 725
ETIOLOGY/PATHOGENESIS 725
CLINICAL ISSUES 725
MACROSCOPIC 725
MICROSCOPIC 725
ANCILLARY TESTS 725
DIFFERENTIAL DIAGNOSIS 726
DIAGNOSTIC CHECKLIST 726
SELECTED REFERENCES 726
Chapter\r195. Cutaneous Gamma-Delta T-Cell Lymphoma 730
TERMINOLOGY 731
ETIOLOGY/PATHOGENESIS 731
CLINICAL ISSUES 731
MICROSCOPIC 731
ANCILLARY TESTS 731
DIFFERENTIAL DIAGNOSIS 732
DIAGNOSTIC CHECKLIST 732
SELECTED REFERENCES 732
Chapter\r196. Angioimmunoblastic T-Cell Lymphoma 736
TERMINOLOGY 737
ETIOLOGY/PATHOGENESIS 737
CLINICAL ISSUES 737
IMAGING 738
MICROSCOPIC 738
ANCILLARY TESTS 738
DIFFERENTIAL DIAGNOSIS 739
DIAGNOSTIC CHECKLIST 739
SELECTED REFERENCES 739
Chapter\r197. Systemic T-Cell and NK-Cell Lymphomas Involving Skin 744
TERMINOLOGY 745
ETIOLOGY/PATHOGENESIS 745
CLINICAL ISSUES 745
MICROSCOPIC 745
ANCILLARY TESTS 746
DIFFERENTIAL DIAGNOSIS 746
DIAGNOSTIC CHECKLIST 746
SELECTED REFERENCES 746
Leukemic and Nonlymphoid Infiltrates 750
Chapter\r198. Leukemia Cutis 750
TERMINOLOGY 751
ETIOLOGY/PATHOGENESIS 751
CLINICAL ISSUES 751
MICROSCOPIC 751
ANCILLARY TESTS 752
DIFFERENTIAL DIAGNOSIS 752
DIAGNOSTIC CHECKLIST 753
SELECTED REFERENCES 753
Chapter\r199. Blastic Plasmacytoid Dendritic Cell Neoplasm 756
TERMINOLOGY 757
ETIOLOGY/PATHOGENESIS 757
CLINICAL ISSUES 757
MACROSCOPIC 758
MICROSCOPIC 758
ANCILLARY TESTS 758
DIFFERENTIAL DIAGNOSIS 758
DIAGNOSTIC CHECKLIST 759
SELECTED REFERENCES 759
Chapter\r200. Extramedullary Hematopoiesis 764
TERMINOLOGY 765
ETIOLOGY/PATHOGENESIS 765
CLINICAL ISSUES 765
MICROSCOPIC 765
ANCILLARY TESTS 765
DIFFERENTIAL DIAGNOSIS 765
SELECTED REFERENCES 765
Chapter\r201. Cutaneous and Systemic Mastocytosis 766
TERMINOLOGY 767
ETIOLOGY/PATHOGENESIS 767
CLINICAL ISSUES 767
MICROSCOPIC 768
ANCILLARY TESTS 769
DIFFERENTIAL DIAGNOSIS 770
SELECTED REFERENCES 770
Part II: Melanocytic Tumors of\rSkin 775
SECTION 1:\rBenign Melanocytic Tumors (Nevi) 775
Chapter\r202. Congenital Melanocytic Nevi 776
TERMINOLOGY 777
CLINICAL ISSUES 777
MICROSCOPIC 777
DIFFERENTIAL DIAGNOSIS 777
SELECTED REFERENCES 777
Chapter\r203. Common Acquired Melanocytic Nevi 778
TERMINOLOGY 779
ETIOLOGY/PATHOGENESIS 779
CLINICAL ISSUES 779
MICROSCOPIC 779
DIFFERENTIAL DIAGNOSIS 780
SELECTED REFERENCES 780
Chapter\r204. Conventional Blue Nevi 782
TERMINOLOGY 783
ETIOLOGY/PATHOGENESIS 783
CLINICAL ISSUES 783
MICROSCOPIC 783
DIFFERENTIAL DIAGNOSIS 783
DIAGNOSTIC CHECKLIST 783
SELECTED REFERENCES 783
Chapter\r205. Cellular Blue Nevi 786
TERMINOLOGY 787
CLINICAL ISSUES 787
MICROSCOPIC 787
ANCILLARY TESTS 787
DIFFERENTIAL DIAGNOSIS 787
DIAGNOSTIC CHECKLIST 787
SELECTED REFERENCES 787
Chapter\r206. Combined Nevi 790
TERMINOLOGY 791
CLINICAL ISSUES 791
MICROSCOPIC 791
DIFFERENTIAL DIAGNOSIS 791
DIAGNOSTIC CHECKLIST 791
SELECTED REFERENCES 791
Chapter\r207. Halo Nevi 792
TERMINOLOGY 793
ETIOLOGY/PATHOGENESIS 793
CLINICAL ISSUES 793
MICROSCOPIC 793
ANCILLARY TESTS 793
DIFFERENTIAL DIAGNOSIS 793
SELECTED REFERENCES 793
Chapter\r208. Nevi of Special Sites 794
TERMINOLOGY 795
CLINICAL ISSUES 795
MACROSCOPIC 795
MICROSCOPIC 795
DIFFERENTIAL DIAGNOSIS 795
DIAGNOSTIC CHECKLIST 795
SELECTED REFERENCES 795
Chapter\r209. Inverted Type A (Clonal) Nevi 798
TERMINOLOGY 799
CLINICAL ISSUES 799
IMAGING 799
MICROSCOPIC 799
ANCILLARY TESTS 799
DIFFERENTIAL DIAGNOSIS 799
DIAGNOSTIC CHECKLIST 799
SELECTED REFERENCES 799
Chapter\r210. Deep Penetrating Nevi 802
TERMINOLOGY 803
ETIOLOGY/PATHOGENESIS 803
CLINICAL ISSUES 803
MICROSCOPIC 803
ANCILLARY TESTS 803
DIFFERENTIAL DIAGNOSIS 803
DIAGNOSTIC CHECKLIST 803
SELECTED REFERENCES 803
Chapter\r211. Conjunctival Melanocytic Nevi 806
TERMINOLOGY 807
CLINICAL ISSUES 807
MICROSCOPIC 807
ANCILLARY TESTS 807
DIFFERENTIAL DIAGNOSIS 807
DIAGNOSTIC CHECKLIST 807
SELECTED REFERENCES 807
Chapter\r212. Dermal Melanocytoses (Nevus of Ota and Ito, Mongolian Spot) 810
CLINICAL ISSUES 811
MICROSCOPIC 811
DIFFERENTIAL DIAGNOSIS 811
SELECTED REFERENCES 811
Chapter\r213. Paraganglioma-Like Dermal Melanocytic Tumor 812
TERMINOLOGY 813
CLINICAL ISSUES 813
MACROSCOPIC 813
MICROSCOPIC 813
ANCILLARY TESTS 813
DIFFERENTIAL DIAGNOSIS 813
DIAGNOSTIC CHECKLIST 813
SELECTED REFERENCES 813
Chapter\r214. Atypical (Dysplastic) Melanocytic Nevi 814
TERMINOLOGY 815
CLINICAL ISSUES 815
MICROSCOPIC 815
ANCILLARY TESTS 815
DIFFERENTIAL DIAGNOSIS 815
DIAGNOSTIC CHECKLIST 816
SELECTED REFERENCES 816
Chapter\r215. Spitz (Spindle and Epithelioid Cell) Nevi 820
TERMINOLOGY 821
CLINICAL ISSUES 821
MACROSCOPIC 821
MICROSCOPIC 821
DIFFERENTIAL DIAGNOSIS 821
SELECTED REFERENCES 821
Chapter\r216. Pigmented Spindle Cell Nevus (Reed Nevus) 826
TERMINOLOGY 827
CLINICAL ISSUES 827
MACROSCOPIC 827
MICROSCOPIC 827
DIFFERENTIAL DIAGNOSIS 827
DIAGNOSTIC CHECKLIST 827
SELECTED REFERENCES 827
SECTION 2:\rMalignant Tumors\r(Melanomas and Related Lesions) 831
Melanoma In Situ 832
Chapter\r217. Melanoma In Situ, Lentigo Maligna Type 832
TERMINOLOGY 833
ETIOLOGY/PATHOGENESIS 833
CLINICAL ISSUES 833
MICROSCOPIC 833
ANCILLARY TESTS 833
DIFFERENTIAL DIAGNOSIS 833
DIAGNOSTIC CHECKLIST 833
SELECTED REFERENCES 833
Chapter\r218. Melanoma In Situ, Superficial Spreading Type 838
TERMINOLOGY 839
CLINICAL ISSUES 839
MICROSCOPIC 839
ANCILLARY TESTS 839
DIFFERENTIAL DIAGNOSIS 839
DIAGNOSTIC CHECKLIST 839
SELECTED REFERENCES 839
Chapter\r219. Melanoma In Situ, Not Otherwise Specified 842
TERMINOLOGY 843
CLINICAL ISSUES 843
MICROSCOPIC 843
ANCILLARY TESTS 843
DIFFERENTIAL DIAGNOSIS 843
DIAGNOSTIC CHECKLIST 843
SELECTED REFERENCES 843
Invasive Melanoma 848
Chapter\r220. Childhood Melanoma 848
TERMINOLOGY 849
ETIOLOGY/PATHOGENESIS 849
CLINICAL ISSUES 849
MACROSCOPIC 850
MICROSCOPIC 850
ANCILLARY TESTS 850
DIFFERENTIAL DIAGNOSIS 851
STAGING 851
REPORTING 851
SELECTED REFERENCES 851
Chapter\r221. Atypical/Borderline and Malignant Spitz Tumors 856
TERMINOLOGY 857
ETIOLOGY/PATHOGENESIS 857
CLINICAL ISSUES 857
MICROSCOPIC 857
ANCILLARY TESTS 857
DIFFERENTIAL DIAGNOSIS 857
DIAGNOSTIC CHECKLIST 857
SELECTED REFERENCES 857
Chapter\r222. Melanoma, Lentigo Maligna Type 860
TERMINOLOGY 861
CLINICAL ISSUES 861
MICROSCOPIC 861
ANCILLARY TESTS 861
DIFFERENTIAL DIAGNOSIS 861
DIAGNOSTIC CHECKLIST 861
SELECTED REFERENCES 861
Chapter\r223. Melanoma, Superficial Spreading Type 864
TERMINOLOGY 865
CLINICAL ISSUES 865
MACROSCOPIC 865
MICROSCOPIC 865
ANCILLARY TESTS 865
DIFFERENTIAL DIAGNOSIS 865
SELECTED REFERENCES 865
Chapter\r224. Melanoma, Nodular Type 870
TERMINOLOGY 871
CLINICAL ISSUES 871
MICROSCOPIC 871
ANCILLARY TESTS 871
DIFFERENTIAL DIAGNOSIS 871
DIAGNOSTIC CHECKLIST 871
SELECTED REFERENCES 871
Chapter\r225. Desmoplastic Melanoma 874
TERMINOLOGY 875
CLINICAL ISSUES 875
MICROSCOPIC 875
ANCILLARY TESTS 875
DIFFERENTIAL DIAGNOSIS 875
SELECTED REFERENCES 875
Chapter\r226. Nevoid Melanoma 878
TERMINOLOGY 879
ETIOLOGY/PATHOGENESIS 879
CLINICAL ISSUES 879
MICROSCOPIC 879
DIFFERENTIAL DIAGNOSIS 879
DIAGNOSTIC CHECKLIST 879
SELECTED REFERENCES 879
Chapter\r227. Acral Lentiginous Melanoma 882
TERMINOLOGY 883
CLINICAL ISSUES 883
MACROSCOPIC 883
MICROSCOPIC 883
DIFFERENTIAL DIAGNOSIS 883
DIAGNOSTIC CHECKLIST 883
SELECTED REFERENCES 883
Chapter\r228. Oral Melanoma 886
TERMINOLOGY 887
ETIOLOGY/PATHOGENESIS 887
CLINICAL ISSUES 887
IMAGING 887
MACROSCOPIC 887
MICROSCOPIC 887
ANCILLARY TESTS 888
DIFFERENTIAL DIAGNOSIS 888
SELECTED REFERENCES 888
Chapter\r229. Mucosal Melanoma (Genital) 890
TERMINOLOGY 891
ETIOLOGY/PATHOGENESIS 891
CLINICAL ISSUES 891
MACROSCOPIC 891
MICROSCOPIC 891
DIFFERENTIAL DIAGNOSIS 891
DIAGNOSTIC CHECKLIST 891
SELECTED REFERENCES 891
Chapter\r230. Sinonasal Melanoma 892
TERMINOLOGY 893
ETIOLOGY/PATHOGENESIS 893
CLINICAL ISSUES 893
IMAGING 893
MACROSCOPIC 893
MICROSCOPIC 893
ANCILLARY TESTS 894
DIFFERENTIAL DIAGNOSIS 894
SELECTED REFERENCES 894
Chapter\r231. Conjunctival Melanoma 898
TERMINOLOGY 899
CLINICAL ISSUES 899
MICROSCOPIC 899
ANCILLARY TESTS 899
DIFFERENTIAL DIAGNOSIS 899
DIAGNOSTIC CHECKLIST 899
SELECTED REFERENCES 899
Chapter\r232. Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus) 902
TERMINOLOGY 903
ETIOLOGY/PATHOGENESIS 903
CLINICAL ISSUES 903
MICROSCOPIC 903
ANCILLARY TESTS 903
DIFFERENTIAL DIAGNOSIS 903
SELECTED REFERENCES 903
Chapter\r233. Pigmented Epithelioid Melanocytoma (\"Animal-Type Melanoma\") 906
TERMINOLOGY 907
ETIOLOGY/PATHOGENESIS 907
CLINICAL ISSUES 907
MICROSCOPIC 907
ANCILLARY TESTS 907
DIFFERENTIAL DIAGNOSIS 907
DIAGNOSTIC CHECKLIST 907
SELECTED REFERENCES 907
Chapter\r234. Primary Dermal Melanoma 910
TERMINOLOGY 911
ETIOLOGY/PATHOGENESIS 911
CLINICAL ISSUES 911
MACROSCOPIC 911
MICROSCOPIC 911
ANCILLARY TESTS 911
DIFFERENTIAL DIAGNOSIS 911
SELECTED REFERENCES 911
Chapter\r235. Other Unusual and Rare Variants of Melanoma 912
TERMINOLOGY 913
ETIOLOGY/PATHOGENESIS 913
CLINICAL ISSUES 913
MICROSCOPIC 913
ANCILLARY TESTS 913
DIFFERENTIAL DIAGNOSIS 913
SELECTED REFERENCES 913
Chapter\r236. Staging for Specimens of Malignant Melanoma of Skin 916
TERMINOLOGY 916
SELECTED REFERENCES 916
INDEX I-i