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Burn Resuscitation, An Issue of Critical Care Clinics, E-Book

Burn Resuscitation, An Issue of Critical Care Clinics, E-Book

Kevin N. Foster | Daniel M. Caruso

(2016)

Additional Information

Abstract

This issue of Critical Care Clinics focuses on Burn Resuscitation in the ICU. Articles include: The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation; The Use of Colloid in Burn Resuscitation; Monitoring and Endpoints of Burn Resuscitation; Vitamin C in Burn Resuscitation; Pediatric Burn Resuscitation; Burn resuscitation in the Austere Environment; Failed Burn resuscitation; and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Burn Resuscitation i
Copyright\r ii
Contributors iii
CONSULTING EDITOR iii
EDITORS iii
AUTHORS iii
Contents vii
Foreword\r vii
Preface: Fluid Resuscitation in Burn Patients: Current Care and New Frontiers\r vii
Introduction: Burn Resuscitation\r vii
The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation\r vii
Colloids in Acute Burn Resuscitation\r vii
Monitoring End Points of Burn Resuscitation\r vii
Vitamin C in Burn Resuscitation\r viii
Pediatric Burn Resuscitation\r viii
Burn Resuscitation in the Austere Environment\r viii
How to Recognize a Failed Burn Resuscitation\r viii
Complicated Burn Resuscitation\r ix
Fluid Creep and Over-resuscitation\r ix
Protocolized Resuscitation of Burn Patients\r ix
Future Therapies in Burn Resuscitation\r ix
CRITICAL CARE CLINICS xi
FORTHCOMING ISSUES xi
January 2017 xi
April 2017 xi
July 2017 xi
RECENT ISSUES xi
July 2016 xi
April 2016 xi
January 2016 xi
Foreword xiii
Preface:\rFluid Resuscitation in Burn Patients: Current Care and New Frontiers xv
Introduction: Burn Resuscitation 489
The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation 491
Key points 491
INTRODUCTION 491
PROGRESSION OF BURN SHOCK AND MULTIORGAN DYSFUNCTION 492
BURN EDEMA AND HYPOVOLEMIA 492
MULTIORGAN DYSFUNCTION AFTER BURN INJURY 496
INFLAMMATORY CYTOKINES AND MEDIATORS OF BURN INJURY 498
Nitric Oxide 499
Oxidative Stress 499
Histamine 500
Coagulation Cascade 500
PREVENTION OF BURN SHOCK 501
REFERENCES 501
Colloids in Acute Burn Resuscitation 507
Key points 507
INTRODUCTION 507
HISTORICAL PERSPECTIVE 508
RELEVANT PHYSIOLOGY RELATED TO COLLOID RESUSCITATION 510
Normal Physiology and Starling Forces 510
Disrupted Physiology After Burns 511
CLINICAL RESUSCITATION WITH COLLOIDS 512
Colloid Composition 512
Nonprotein semisynthetic colloids 512
Hydroxyethyl starch solutions 512
Gelatins 513
Dextrans 513
Protein colloids 513
Fresh frozen plasma 513
Albumin 514
Colloid Timing and Dose 515
Immediate dedicated colloid use 517
Later responsive use of colloids 518
SUMMARY 519
REFERENCES 519
Monitoring End Points of Burn Resuscitation 525
Key points 525
INTRODUCTION 525
Shock and Burn Shock 525
Goals of Burn Resuscitation and Monitoring 526
END POINTS OF BURN RESUSCITATION 526
First-Line Monitoring 526
HEMODYNAMIC END POINTS OF RESUSCITATION 527
Goal-Directed Therapy 527
Mixed Venous Oxygen Saturation/Central Venous Oxygen Saturation 528
Arterial Waveform Pulse Analysis 528
Echocardiography 529
PERFUSION MARKERS 530
Lactate 530
Base Deficit 530
Near-Infrared Spectroscopy 531
Gastric Tonometry 531
Sublingual Capnometry 532
SUMMARY 532
ACKNOWLEDGMENTS 532
REFERENCES 532
Vitamin C in Burn Resuscitation 539
Key points 539
INTRODUCTION 539
PATHOPHYSIOLOGY: INCREASED CAPILLARY PERMEABILITY 540
ANTIOXIDANT THERAPY 540
VITAMIN C 541
VITAMIN C: PRECLINICAL BURN STUDIES 541
VITAMIN C: CLINICAL BURN STUDIES 541
VITAMIN C: MECHANISMS OF ACTION IN BURN INJURY 543
VITAMIN C: SIDE EFFECTS 543
VITAMIN C: DOSING 543
SUMMARY 544
REFERENCES 544
Pediatric Burn Resuscitation 547
Key points 547
INTRODUCTION 547
PATIENT EVALUATION OR OVERVIEW 548
Differences Between Children and Adults 548
Airway 548
Breathing 548
Circulation 548
Neurologic 549
Skin 549
Initial Evaluation 550
History 550
Physical examination 550
Initial Resuscitation 550
Airway 550
Breathing 551
Circulatory status 551
Wound assessment 552
PHARMACOLOGIC TREATMENT OPTIONS 553
Airway 553
Breathing 553
Circulation 553
Neurologic 553
Wound 554
NONPHARMACOLOGIC TREATMENT OPTIONS 554
Nutrition 554
Physical and Occupational Therapy 554
Child Life and Distraction Therapies 554
COMBINATION THERAPIES 555
SURGICAL TREATMENT OPTIONS 555
Escharotomy 555
Early Excision 555
TREATMENT RESISTANCE OR COMPLICATIONS 556
Airway 556
Breathing 556
Circulation 556
Neurologic 556
Wound Infection or Poorly Healing Wounds 557
EVALUATION OF OUTCOME AND LONG-TERM RECOMMENDATIONS 557
SUMMARY 557
REFERENCES 558
Burn Resuscitation in the Austere Environment 561
Key points 561
INTRODUCTION 561
PATIENT EVALUATION OVERVIEW 562
PHARMACOLOGIC TREATMENT OPTIONS 563
EVALUATION OF OUTCOME AND LONG-TERM RECOMMENDATIONS 564
SUMMARY 564
REFERENCES 564
How to Recognize a Failed Burn Resuscitation 567
Key points 567
INTRODUCTION 567
RECOGNIZING A FAILED BURN RESUSCITATION 568
EARLY FAILURE OF RESUSCITATION 569
IN-RESUSCITATION FAILURE 570
LATE FAILURE OF RESUSCITATION 571
TRANSITIONING GOALS OF CARE 573
SUMMARY 573
REFERENCES 573
Complicated Burn Resuscitation 577
Key points 577
INTRODUCTION 577
HEART FAILURE 577
RENAL FAILURE 579
CIRRHOSIS 581
ELECTRICAL INJURY 582
INHALATION INJURY 583
SUMMARY 584
REFERENCES 584
Fluid Creep and Over-resuscitation 587
Key points 587
INTRODUCTION 587
HISTORICAL CONTEXT 588
FLUID CREEP BEGINS 588
Fluid Creep: The New Normal? 588
How Much Is Too Much? 591
Causes of Fluid Creep: Fluid Begets Fluid 592
MANAGING FLUID CREEP 593
Develop a Protocol 593
Start Small 594
Follow the Curve 594
Consider Colloid 594
Other Rescue Strategies 594
Hypertonic saline 594
High-dose ascorbic acid 595
SUMMARY 595
REFERENCES 595
Protocolized Resuscitation of Burn Patients 599
Key points 599
INTRODUCTION 599
PROTOCOLIZED BURN RESUSCITATION 601
COMPUTERIZED BURN RESUSCITATION 602
COMPUTERIZED DECISION SUPPORT: CLINICAL EXPERIENCE 606
SUMMARY 608
REFERENCES 608
Future Therapies in Burn Resuscitation 611
Key points 611
INTRODUCTION 611
RESUSCITATIVE FLUIDS 612
RESUSCITATION VOLUMES 613
APPROACHES TO MONITORING 614
THE HYPERMETABOLIC STATE 615
SUMMARY 616
REFERENCES 616
Index 621