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Meningiomas, An issue of Neurosurgery Clinics of North America, E-Book

Meningiomas, An issue of Neurosurgery Clinics of North America, E-Book

Gabriel Zada | Randy L. Jensen

(2016)

Additional Information

Abstract

This issue focuses on meningiomas and includes articles on Incidental Meningiomas: Management Strategies in the Modern Neuroimaging Era, Advanced Neuroimaging for Intracranial Meningiomas, Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas, Preoperative Embolization for Intracranial Meningiomas, Management of Spinal Meningiomas, Medical Management of Meningiomas: Current Status, Failed Treatments and Promising Horizons, and many more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Meningiomas\r i
Copyright\r ii
Contributors iii
CONSULTING EDITORS iii
EDITORS iii
AUTHORS iii
Contents vii
Preface: Meningiomas: An Update on Diagnostic and Therapeutic Approaches\r vii
Advanced Imaging of Intracranial Meningiomas\r vii
Predicting Meningioma Consistency on Preoperative Neuroimaging Studies\r vii
Strategic and Technical Considerations for the Endovascular Embolization of Intracranial Meningiomas\r vii
Genomic and Epigenomic Landscape in Meningioma\r viii
Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup\x0B viii
Primary Intraosseous Meningioma\r viii
Management of Spinal Meningiomas\r viii
Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas\r ix
The Contemporary Role of Stereotactic Radiosurgery in the Treatment of Meningiomas\r ix
Incidental Meningiomas: Management in the Neuroimaging Era\r ix
Management of Atypical and Anaplastic Meningiomas\r ix
Medical Management of Meningiomas: Current Status, Failed Treatments, and Promising Horizons\r x
Index\r x
NEUROSURGERY CLINICS OF NORTH AMERICA\r xi
FORTHCOMING ISSUES xi
July 2016 xi
October 2016 xi
January 2017 xi
RECENT ISSUES xi
January 2016 xi
October 2015 xi
July 2015 xi
Preface: Meningiomas: An \rUpdate on Diagnostic and Therapeutic Approaches xiii
Advanced Imaging of Intracranial Meningiomas 137
Key points 137
BACKGROUND 137
PERFUSION IMAGING 138
DIFFUSION IMAGING 140
SPECTROSCOPY 141
NUCLEAR MEDICINE 142
SUMMARY 142
REFERENCES 142
Predicting Meningioma Consistency on Preoperative Neuroimaging Studies 145
Key points 145
INTRODUCTION 145
REFERENCE STANDARDS OF MENINGIOMA CONSISTENCY 146
NEUROIMAGING STUDIES OF MENINGIOMA CONSISTENCY 146
Conventional MRI 146
Diffusion MRI 147
Magnetic Resonance Elastography 151
Magnetic Resonance Spectroscopy 152
Computed Tomography 152
Other Imaging Techniques 152
SUMMARY 153
REFERENCES 153
Strategic and Technical Considerations for the Endovascular Embolization of Intracranial Meningiomas 155
Key points 155
INTRODUCTION: NATURE OF THE PROBLEM 155
INDICATIONS AND CONTRAINDICATIONS 156
OPERATIVE TECHNIQUE AND PROCEDURE 156
Preoperative Planning 156
PROCEDURAL CONSIDERATIONS 156
Timing 156
Preparation and Patient Positioning 157
SURGICAL APPROACH AND SURGICAL PROCEDURE 157
Endovascular Technique 157
SELECTION OF AN EMBOLIC AGENT 158
Particles 158
Liquid Embolic Agents 160
Other Embolic Agents 160
DANGEROUS ANASTOMOSES 160
Orbital Region 160
Parasellar Region 160
Petroclival Region 160
Cervicomedullary Region 162
Cranial Nerve Blood Supply 162
COMPLICATIONS AND THEIR MANAGEMENT 162
POSTOPERATIVE CARE 164
OUTCOMES 164
SUMMARY 164
REFERENCES 164
Genomic and Epigenomic Landscape in Meningioma 167
Key points 167
INTRODUCTION 167
GENOMICS AND EPIGENOMICS IN MENINGIOMA 168
Genetic Alterations 168
Chromosomal Copy Number Alterations 169
Epigenetic Alterations 169
MOLECULAR TAXONOMY IN MENINGIOMA 172
Genetic Hallmarks of Meningioma Subtypes 172
Epigenetic Stratification of Meningiomas 173
MOLECULAR PREDICTORS OF CLINICAL OUTCOME 173
SUMMARY 176
ACKNOWLEDGEMENT 176
REFERENCES 176
Secretory Meningiomas 181
Key points 181
INTRODUCTION 181
CLINICAL PRESENTATION AND IMAGING 181
HISTOPATHOLOGY AND GENETICS 182
CLINICAL MANAGEMENT AND COMPLICATIONS 184
SUMMARY 185
REFERENCES 185
Primary Intraosseous Meningioma 189
Key points 189
INCIDENCE 189
ETIOLOGY 189
CLINICAL PRESENTATION 190
RADIOGRAPHIC APPEARANCE 190
DIFFERENTIAL DIAGNOSIS 191
HISTOPATHOLOGY 191
NOMENCLATURE AND CLASSIFICATION 191
TREATMENT 192
SUMMARY 192
REFERENCES 193
Management of Spinal Meningiomas 195
Key points 195
INTRODUCTION 195
Epidemiology 195
Surgical Management 196
Genetic and Molecular Markers 197
Tumor Locations 197
PATIENT EVALUATION OVERVIEW 198
SURGICAL APPROACH 199
Neuromonitoring 201
SURGICAL COMPLICATIONS 201
FUNCTIONAL AND NEUROLOGIC OUTCOME 202
SPINAL MENINGIOMA RECURRENCE 202
PHARMACOLOGIC TREATMENT OPTIONS 202
ADJUVANT RADIOTHERAPY AND RADIOSURGERY 203
SUMMARY/DISCUSSION 203
SUPPLEMENTARY DATA 203
REFERENCES 203
Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas 207
Key points 207
INTRODUCTION 207
THE SUPRAORBITAL KEYHOLE APPROACH 207
The Supraorbital Keyhole Approach Technique 209
THE ENDOSCOPIC ENDONASAL APPROACH 210
The Endoscopic Endonasal Approach Technique 210
DISCUSSION 212
SUMMARY 213
REFERENCES 213
The Contemporary Role of Stereotactic Radiosurgery in the Treatment of Meningiomas 215
Key points 215
INTRODUCTION 215
Meningioma Classification and Epidemiology 215
Brief Overview of Resection 216
The Evolution of Radiosurgery 216
THE RADIOBIOLOGY OF RADIOSURGERY 218
RADIOSURGICAL RESULTS FOR WORLD HEALTH ORGANIZATION CLASS I BENIGN MENINGIOMAS 219
The Effect of Dose and Tumor Volume on Prognosis 219
Tumor Control Rates Based on the Duration of Follow-up 219
Stereotactic Radiosurgery as a Primary Treatment Modality 220
Long-term Radiosurgical Outcomes 220
Skull Base Meningiomas 221
Convexity Meningiomas 222
RADIOSURGERY FOR ATYPICAL AND MALIGNANT MENINGIOMAS 222
RADIOSENSITIVITY OF CRANIAL NERVES 223
HYPOFRACTIONATED STEREOTACTIC RADIOSURGERY 223
STEREOTACTIC RADIOSURGERY–INDUCED COMPLICATIONS 224
SUMMERY: THE ROLE FOR STEREOTACTIC RADIOSURGERY IN THE MANAGEMENT OF MENINGIOMAS 224
REFERENCES 225
Incidental Meningiomas 229
Key points 229
INTRODUCTION 229
DIAGNOSTIC NEUROIMAGING TECHNIQUES 230
MRI 230
Computed Tomography 230
Single-Photon Emission Computed Tomography 232
MANAGEMENT 232
Surgical Resection 232
Radiation 233
Observation 234
SUMMARY 235
REFERENCES 235
Management of Atypical and Anaplastic Meningiomas 239
Key points 239
INTRODUCTION 239
PATIENT EVALUATION OVERVIEW 240
SURGICAL TREATMENT OPTIONS 242
BRACHYTHERAPY 242
RADIOTHERAPY TREATMENT OPTIONS 242
PHARMACOLOGIC TREATMENT OPTIONS 243
TREATMENT RESISTANCE OR COMPLICATIONS 243
EXPERIMENTAL THERAPIES 244
EVALUATION OF OUTCOME AND LONG-TERM RECOMMENDATIONS 245
SUMMARY AND DISCUSSION 245
REFERENCES 245
Medical Management of Meningiomas 249
Key points 249
INTRODUCTION 249
MUTATIONS IN MENINGIOMA 251
ANGIOGENIC PATHWAY INHIBITORS 254
TYROSINE KINASE RECEPTOR INHIBITORS 255
HYDROXYUREA 255
HORMONE RECEPTOR TARGETED AGENTS 255
CHEMOTHERAPEUTIC AGENTS 256
SOMATOSTATIN ANALOGUES 256
IMMUNOMODULATION 256
EMERGING APPROACHES 256
REFERENCES 257
Index 261