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Advances in Acne Management, An Issue of Dermatologic Clinics, E-Book

Advances in Acne Management, An Issue of Dermatologic Clinics, E-Book

James Q. Del Rosso | Joshua A. Zeichner

(2016)

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Book Details

Abstract

This most common of all dermatologic conditions seen by dermatologists. What are new developments. What do dermatologists need to best treat their patients? In this issue of Dermatologic Clinics, expert practitioners and academics, Dr. James Del Rosso and Dr. Joshua Zeichner lead distinguished clinicians in presenting such topics as: How the Internet and Social Media Have Changed the Management of Acne; Evaluation of Acne Scars: How to Assess Them and What To Tell The Patient; Pathophysiology of Acne; The Role of Skin Care in the Management of Acne Vulgaris; Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris; Use of Oral Contraceptives for Acne Vulgaris: Practical Considerations in Real World Practice; Use of Antibiotics in Acne: Achieving Optimal Outcomes While Maintaining Antibiotic Stewardship; Status Report on Oral Isotretinoin: Has Anything Changed That Is Relevant to Clinicians?; Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne; Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men; Physical Modalities in the Management of Acne; 12. Cases of "Acne" That Turned Out To Not Be Acne.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Advances in Acne Management\r i
Copyright\r ii
Contributors iii
CONSULTING EDITOR iii
EDITORS iii
AUTHORS iii
Contents v
Preface: Face to Face with Acne in 2016 and Beyond\r v
Acne and the Internet\r v
The Relationship of Proper Skin Cleansing to Pathophysiology, Clinical Benefits, and\rthe Concomitant Use of Prescription Topical Therapies in Patients with Acne Vulgaris\r v
Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris\r v
Use of Oral Contraceptives for Management of Acne Vulgaris: Practical Considerations in Real World Practice\r v
The Clinical Relevance of Antibiotic Resistance: Thirteen Principles That Every\rDermatologist Needs to Consider When Prescribing Antibiotic Therapy\r vi
Oral Isotretinoin: New Developments Relevant to Clinical Practice\r vi
Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne\r vi
Pediatric Acne: Clinical Patterns and Pearls\r vi
Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men\r vii
Evaluation of Acne Scars: How to Assess Them and What to Tell the Patient\r vii
Physical Modalities (Devices) in the Management of Acne\r vii
When Acne is Not Acne\r vii
DERMATOLOGIC CLINICS\r viii
FORTHCOMING ISSUES viii
July 2016 viii
October 2016 viii
January 2017 viii
RECENT ISSUES viii
January 2016 viii
October 2015 viii
July 2015 viii
Preface: Face to Face with Acne in 2016 and Beyond \r ix
Acne and the Internet 129
Key points 129
INTRODUCTION 129
WHAT IS OUT THERE 129
Educational Websites from Well-respected Organizations 130
Promotional Websites 130
Independent Websites from Self-proclaimed Authorities 130
Social Media 131
ONLINE DANGERS 131
SUMMARY 132
REFERENCES 132
The Relationship of Proper Skin Cleansing to Pathophysiology, Clinical Benefits, and the Concomitant Use of Prescription To ... 133
Key points 133
INTRODUCTION 134
ACNE PATHOGENESIS 134
Follicular Wall Barrier Dysfunction 134
Calcium Gradient 135
Subclinical Inflammation 136
Androgens 136
Propionibacterium acnes 136
Biofilms 136
TOPICAL ACNE PRESCRIPTION THERAPIES AND THE SKIN BARRIER 137
Topical Retinoids 137
Benzoyl Peroxide 137
CLEANSER BASICS FOR PATIENTS WITH ACNE 138
Soaps 138
Synthetic Detergent Cleansers 138
Combars 138
Lipid-free Cleansers 139
CLINICAL STUDIES EVALUATING THE BENEFITS OF USING MILD CLEANSERS IN ACNE 139
FREQUENCY OF CLEANSING IN ACNE 140
DISCUSSION/SUMMARY 141
REFERENCES 142
Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris 147
Key points 147
INTRODUCTION 147
ACNE DURATION AND INFLAMMATION CORRELATE TO THE DEGREE OF SCARRING 147
ANTIBIOTIC RESISTANCE CAN BE ASSOCIATED WITH REDUCED CLINICAL RESPONSE AND DRIVES RESISTANCE IN PROPIONIBACTERIUM ACNES AND ... 149
ACUTE FLARE OF ACNE ON COMMENCING ORAL ISOTRETINOIN: BE AWARE OF THE MACROCOMEDONE 149
ISOTRETINOIN ABSORPTION IS FOOD DEPENDENT. AN EMPTY STOMACH MAY REDUCE ABSORPTION LEADING TO A SIGNIFICANT REDUCTION IN BLO ... 150
CONSIDER HOW TO MANAGE ADVERSE EFFECTS AND INTERACTIONS OF TOPICAL AGENTS TO OPTIMIZE EFFICACY: AVOID IRRITATION, COSMETIC ... 151
EVIDENCE TO SUPPORT HIGH-DOSE DOXYCYCLINE PLUS A FIXED COMBINATION PRODUCT AS AN ALTERNATIVE TO ORAL ISOTRETINOIN IN SEVERE ... 151
ANTIHISTAMINES AMELIORATE THE ADVERSE EFFECTS OF ORAL ISOTRETINOIN AND ACT AS AN ADJUVANT IN THE MANAGEMENT OF MODERATE TO ... 152
SPIRONOLACTONE AS AN ALTERNATIVE TO COMBINED ORAL CONTRACEPTIVES IN FEMALE PATIENTS WHO REQUIRE AN ANTIANDROGEN THERAPY 152
LONG-TERM ANTIBIOTICS MAY LEAD TO GRAM-NEGATIVE FOLLICULITIS 153
BE AWARE OF ANABOLIC STEROIDS, NUTRITIONAL, AND VITAMIN SUPPLEMENTS AS A TRIGGER FOR ACNE OR ACNEIFORM ERUPTIONS 155
Vitamins B2, B6, and B12 155
REFERENCES 155
Use of Oral Contraceptives for Management of Acne Vulgaris 159
Key points 159
COMBINATION ORAL CONTRACEPTIVE PILLS 159
MECHANISM OF ACTION IN ACNE 160
EFFICACY IN ACNE 160
BENEFITS 160
RISKS 160
Cardiovascular Risks 161
Cancer Risks 161
Bone Risks 161
CONTRAINDICATIONS 162
WHEN TO USE 162
HOW TO USE 162
ADVERSE EFFECTS 164
REFERENCES 164
The Clinical Relevance of Antibiotic Resistance 167
Key points 167
MAJOR PREMISE 167
MAJOR PREMISE 168
MAJOR PREMISE 169
MAJOR PREMISE 171
REFERENCES 171
Oral Isotretinoin 175
Key points 175
INTRODUCTION 175
Mechanism of Action 176
Enhancing Bioavailability 176
Efficacy 177
Low and Alternative Dosing Regimens 177
Relapse 178
Pregnancy Prevention 179
Mental Health Disorders 180
Inflammatory Bowel Disease 181
Abnormal Wound Healing 181
SUMMARY 181
REFERENCES 182
Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne 185
Key points 185
INTRODUCTION 185
TETRACYCLINES 185
SPIRONOLACTONE 186
ISOTRETINOIN 187
SUMMARY 190
REFERENCES 190
Pediatric Acne 195
Key points 195
INTRODUCTION 195
PEDIATRIC PHYSIOLOGY 195
NEONATAL ACNE 196
INFANTILE ACNE 197
MIDCHILDHOOD ACNE 199
PREADOLESCENT ACNE 199
SUMMARY 200
REFERENCES 200
Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men 203
Key points 203
REFERENCES 206
Evaluation of Acne Scars 207
Key points 207
INTRODUCTION 207
HISTORY 207
PHYSICAL EXAMINATION 208
PATIENT DISCUSSION AND DEVELOPMENT OF TREATMENT PLAN 209
SUMMARY 212
REFERENCES 212
Physical Modalities (Devices) in the Management of Acne 215
Key points 215
INTRODUCTION 215
VISIBLE LIGHT PHOTOTHERAPY 215
Blue Light 215
Blue Light and Red Light 216
Intense Pulsed Light 216
LASER LIGHT SOURCES 216
Pulsed Dye Laser 216
Potassium Titanyl Phosphate Laser 217
Infrared Lasers 217
1450 nm 217
1540 nm 218
1550 nm 218
1064 and 1320 nm 218
Photodynamic Therapy 218
OTHER MODALITIES 219
Radiofrequency 219
Photopneumatic Therapy 220
Microdermabrasion 220
Ultraviolet A and Ultraviolet B 220
Home Use Light Devices 220
SUMMARY 221
REFERENCES 221
When Acne is Not Acne 225
Key points 225
HISTORY 225
DIAGNOSIS AND MANIFESTATIONS 226
CONFIRMATION OF DIAGNOSIS AND MANAGEMENT 226
SUMMARY 228
REFERENCES 228
Index 229