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Case Studies in Neurology, An Issue of Neurologic Clinics, E-Book

Case Studies in Neurology, An Issue of Neurologic Clinics, E-Book

Randolph W. Evans

(2016)

Additional Information

Abstract

This issue of the Neurologic Clinics is being edited by the series Consulting Editor, Dr. Randolph Evans, and will be a special issue focusing on patient case studies of a board range of neurological diseases and disorders. Topics and cases covered include, but are not limited to: cerebrovascular disease, multiple sclerosis, syncope, epilepsy, tremor, dementia, neurologic issues in pregnancy, and medicolegal cases.

Table of Contents

Section Title Page Action Price
Front Cover Cover
NEUROLOGIC CLINICS\r i
Copyright\r ii
Contributors iii
CONSULTING EDITOR iii
EDITOR iii
AUTHORS iii
Contents vii
Preface\r vii
Neurology Case Studies: Cerebrovascular Disease\r vii
Neurotherapeutic Strategies for Multiple Sclerosis\r vii
Syncope: Case Studies\r vii
Distal Myopathies: Case Studies\r vii
Sleep Disorders in Neurologic Practice: A Case-based Approach\x0B viii
Evaluating and Treating Epilepsy Based on Clinical Subgroups: Elderly Onset Seizure and Medically Resistant Partial-Onset E ... \r viii
Neuro-Ophthalmology Cases for the Neurologist\r viii
Case Studies of Uncommon and Rare Headache Disorders\r ix
Case Studies in Tremor\r ix
Functional Disorders in Neurology: Case Studies\r ix
Case Studies in Neurocritical Care\r ix
Case Studies Illustrating Focal Alzheimer’s, Fluent Aphasia, Late-Onset Memory Loss, and Rapid Dementia\r x
Neurology of Pregnancy: A Case-Oriented Review\r x
Sports Neurology in Clinical Practice: Case Studies\r x
Neurological Fallacies Leading to Malpractice: A Case Studies Approach\r xi
NEUROLOGIC CLINICS\r xii
FORTHCOMING ISSUES xii
November 2016 xii
February 2017 xii
May 2017 xii
RECENT ISSUES xii
May 2016 xii
February 2016 xii
November 2015 xii
Preface:\rCase Studies in Neurology xiii
REFERENCE xiv
Neurology Case Studies 467
Key points 467
CASE 1: MANAGEMENT OF SYMPTOMATIC INTRACRANIAL ARTERY STENOSIS 467
Case Presentation 467
Clinical Questions 468
Discussion 468
CASE 2: AN INTERESTING CASE OF MIGRAINE HEADACHE AND STROKE 471
Case Presentation 471
Clinical Questions 471
Discussion 472
CASE 3: A PATIENT WITH RETINAL ARTERY OCCLUSIONS AND OTITIC NERVOUS SYSTEM INVOLVEMENT 472
Case Presentation 472
Clinical Questions 473
Discussion 473
CASE 4: INTRACRANIAL OCCLUSIVE DISEASE 474
Case Presentation 474
Clinical Questions 474
Discussion 475
CASE 5: AN IMPORTANT HERITABLE CAUSE OF STROKE AND VASCULAR DEMENTIA 476
Case Presentation 476
Clinical Questions 476
Discussion 476
CASE 6: AN INTERESTING CLINICO-NEURORADIOLOGIC ENTITY IN PREGNANCY 479
Case Presentation 479
Clinical Questions 479
Discussion 479
SUMMARY 480
REFERENCES 481
Neurotherapeutic Strategies for Multiple Sclerosis 483
Key points 483
INTRODUCTION 484
UNITED STATES FOOD AND DRUG ADMINISTRATION–APPROVED MULTIPLE SCLEROSIS THERAPIES 484
Injectables 484
Interferon-beta 484
Monitoring interferons 486
Adverse reactions 486
Neutralizing antibodies 486
Glatiramer acetate 487
Adverse reactions 487
Isolated postinjection reaction 487
Injection site reactions 487
Lipoatrophy 487
Orals 487
Fingolimod 487
Adverse effects 487
Laboratory derangements 487
Cardiac effects 488
Ophthalmic complications 488
Infections 488
Neoplasms 488
Pulmonary complications 488
Worsening of disease activity 488
Monitoring 488
Teriflunomide 488
Adverse effects 490
Dosing and monitoring 490
Dimethyl fumarate 491
Adverse effects 492
Dosing and monitoring 492
Infusions 493
Natalizumab 493
Infusion-related reactions 493
Antinatalizumab antibodies 493
Laboratory abnormalities 494
Infections 494
Progressive multifocal leukoencephalopathy 494
Cessation of natalizumab therapy 495
Extended-interval dosing of natalizumab 496
Alemtuzumab 497
Adverse effects 498
Infusion-related reactions 498
De novo autoimmunity 498
Infections 498
Malignancy 498
Role in multiple sclerosis therapy 498
Rituximab 499
Dosage and monitoring 499
Adverse reactions 499
Azathioprine 499
Methotrexate 499
Mycophenolate mofetil 500
Adverse effects 500
Dosing and monitoring 500
Mitoxantrone 500
Choosing a DMT 500
Fertility and pregnancy 501
USE OF DMTS DURING PREGNANCY 502
Multiple Sclerosis Exacerbation and its Management 503
Management of acute relapses during pregnancy 503
Use of symptomatic therapies 503
Corticosteroid therapy 505
Corticosteroid therapy for acute exacerbations 505
Pulsed corticosteroid therapy 505
Syncope: Case Studies 525
Key points 525
INTRODUCTION 525
REFLEX SYNCOPE 526
Case 1 526
VASOVAGAL SYNCOPE 526
TILT-TABLE TESTING 529
Case 2 530
CAROTID SINUS HYPERSENSITIVITY 530
SITUATIONAL SYNCOPE 531
Case 3 531
CONVULSIVE SYNCOPE 532
ORTHOSTATIC HYPOTENSION 533
Case 4 533
CHRONIC AUTONOMIC NEUROPATHY 534
Case 5 535
ACUTE AND SUBACUTE AUTONOMIC NEUROPATHY 535
Case 6 536
PARKINSONISM AND AUTONOMIC FAILURE 537
TREATMENT OF ORTHOSTATIC HYPOTENSION 537
Case 7 538
IDIOPATHIC ORTHOSTATIC INTOLERANCE 538
REFERENCES 539
Distal Myopathies 547
Key points 547
CASE 1: DYSPHAGIA AND HANDS WEAKNESS (SEE FIG. 1 FOR VIDEO 1) 547
Reference 548
CASE 2: CHRONIC DYSPHAGIA AND HANDS STIFFNESS (SEE FIG. 2 FOR VIDEO 2) 549
Reference 550
CASE 3: FACIAL WEAKNESS, DYSPHAGIA, AND DISTAL WEAKNESS (SEE FIG. 3 FOR VIDEO 3) 550
Reference 551
CASE 4: SCAPULAR WINGING AND FOOT DROP (SEE FIG. 4 FOR VIDEO 4) 551
CASE 5: SEVERE PROXIMAL AND DISTAL WEAKNESS (SEE FIG. 5 FOR VIDEO 5) 552
CASE 6: CHRONIC FACIAL AND HAND GRIP WEAKNESS (SEE FIG. 6 FOR VIDEO 6) 554
CASE 7: A POLICEMAN WHO COULD NOT PULL THE TRIGGER (SEE FIG. 7 FOR VIDEO 7) 555
References 556
) 556
Reference 557
CASE 9: BILATERAL FOOT DROP AND QUADRICEPS WEAKNESS (SEE FIG. 9 FOR VIDEO 9) 558
References 559
CASE 10: WRIST AND FINGER FLEXORS WEAKNESS AND MYOPATHIC ELECTROMYOGRAM (SEE FIG. 10 FOR VIDEO 10) 559
Reference 560
CASE 11: FAMILIAL HOARSENESS AND FOOT DROP (SEE FIG. 11 FOR VIDEO 11) 560
Diagnosis 561
CASE 12: A FISHERMAN WHO CANNOT PEEL SHRIMP ANYMORE (SEE FIG. 12 FOR VIDEO 12) 562
Reference 563
CASE 13: PAINLESS FINGERS DROP (SEE FIG. 13 FOR VIDEO 13) 563
Reference 564
SUPPLEMENTARY DATA 564
Sleep Disorders in Neurologic Practice 565
Key points 565
CASE A: EPILEPSY AND SLEEP DISORDERED BREATHING 565
Case Presentation 565
Clinical Questions 566
Discussion 566
Summary of Case Presentation 569
CASE B: MULTIPLE SCLEROSIS AND INSOMNIA 569
Case Presentation 569
Clinical Questions 569
Discussion 569
Summary of Case Presentation 571
CASE C: ALZHEIMER DISEASE AND CIRCADIAN RHYTHM DISORDER, ADVANCED SLEEP PHASE TYPE 571
Case Presentation 572
Clinical Questions 572
Discussion 572
Summary of Case Presentation 574
CASE D: SECONDARY NARCOLEPSY IN A PATIENT WITH NEUROSARCOIDOSIS OF THE HYPOTHALAMUS 574
Case Presentation 574
Clinical Questions 575
Discussion 576
Summary of the Case Presentation 578
CASE E: RESTLESS LEGS SYNDROME MANIFESTING WITH SLEEP-ONSET INSOMNIA, POOR QUALITY OF LIFE, AND EXCESSIVE SLEEPINESS 579
Case Presentation 579
Clinical Questions 579
Discussion 579
Summary of the Case Presentation 581
CASE F: RAPID EYE MOVEMENT SLEEP BEHAVIOR DISORDER 582
Case Presentation 582
Clinical Questions 582
Discussion 582
Summary of the Case Presentation 585
SUMMARY 586
REFERENCES 586
Evaluating and Treating Epilepsy Based on Clinical Subgroups 595
Key points 595
INTRODUCTION 595
CASE 1: EPILEPSY IN THE ELDERLY 596
What is the Differential Diagnosis for Episodes of Confusion in the Elderly? 596
What Features in This Patient’s History Help Distinguish Seizure from Other Causes Such As Syncope? 597
What Clinical Tests are Useful for Evaluating Seizures in This 60-Year-Old Patient? 598
How Common is New-Onset Epilepsy in Older Adults Such As This Patient, and What are Important Causes of Seizures in the Eld ... 598
What are the Most Common Causes of New-Onset Seizures in the Elderly? 599
How are Seizures Linked to Hypertension and Microvascular Disease? 600
In Addition to Blood Pressure Control, What Lifestyle Modifications Would Help This Patient? 600
What Special Considerations Affect the Choice of Antiepileptic Drugs in This Patient and in the Elderly? 601
CASE 2: MEDICALLY RESISTANT EPILEPSY 602
Does This Patient Have Drug-Resistant Epilepsy? 602
What are Additional Treatment Options for Her? 602
This Patient’s Goal is to Obtain Her Drivers’ License and Minimize Disability Associated with Seizures. What are the Next S ... 603
What Additional Testing Should be Done on This Patient? 604
Is This Patient a Surgical Candidate? 604
Would This Patient Still be a Surgical Candidate if Her MRI was Normal? 605
Would This Patient Still be a Surgical Candidate if Her Scalp Electroencephalogram did Not Show a Clear Lateralization? 605
What is This Patient’s Expected Seizure Outcome from Left Temporal Lobectomy? 605
Will She Have Any Memory or Speech Impairment After Surgery? 605
What if She had Frontal Lobe Epilepsy Rather than Temporal Lobe Epilepsy? Would She Still be a Surgical Candidate? 605
This Patient Wants to Minimize Her Risks for Cognitive Loss and Minimize Recovery Time after Surgery. Are There Alternative ... 606
If This Patient had Both Left and Right Temporal Lobe Seizures During Video Electroencephalogram Monitoring, Would She Have ... 606
REFERENCES 607
Neuro-Ophthalmology Cases for the Neurologist 611
Key points 611
INTRODUCTION 611
CASE 1: GIANT CELL ARTERITIS 612
Clinical Questions 613
Discussion 613
CASE 2: MUCORMYCOSIS 614
Clinical Questions 615
Discussion 615
CASE 3: PITUITARY APOPLEXY 616
Clinical Questions 616
Discussion 617
CASE 4: THIRD NERVE PALSY 621
Clinical Questions 621
Discussion 621
CASE 5: CAROTID ARTERY DISSECTION 623
Clinical Questions 624
Discussion 624
SUMMARY 626
ACKNOWLEDGMENTS 626
REFERENCES 626
Case Studies of Uncommon and Rare Headache Disorders 631
Key points 631
CASE 1. A 12-DAY MIGRAINE WITH RECURRING AURA? 631
Neuroimaging 633
CASE 2. A MIGRAINEUR WITH A NEW CONSTANT HEADACHE FOR 1 MONTH 634
Neuroimaging and Follow-up 635
CASE 3. AN ORTHOSTATIC HEADACHE 636
Neuroimaging Results 638
CASE 4. A UNILATERAL HEADACHE 638
CASE 5. MIGRAINE WITH AURA AND LIMB PAIN WITHOUT HEADACHE 640
CASE 6. NOCTURNAL HEADACHES 644
REFERENCES 646
Case Studies in Tremor 651
Key points 651
CASE 1: TREMOR IN A WOMAN WITH BIPOLAR DISEASE 651
Case Presentation 651
What Are the Key Features of the History Which Will Help Achieve the Diagnosis? 652
What Features of the Examination Will Help to Achieve the Diagnosis? 652
Is Additional Testing Necessary? 653
What Is the Treatment and How Do I Counsel the Patient? 654
CASE 2: ASYMMETRIC TREMOR IN A MAN WITH COMPLAINTS OF IMPAIRED ACTIVITIES OF DAILY LIVING 655
Case Presentation 655
What Features of the History Will Help to Achieve a Diagnosis? 655
What Features of the Examination Will Help to Achieve a Diagnosis? 655
Is Additional Testing Necessary? 656
What Is the Treatment and How Do I Counsel the Patient? 657
CASE 3: A WOMAN WITH 1 YEAR OF NECK TREMOR 657
Case Presentation 657
What Are the Key Features of the History Which Will Help Achieve the Diagnosis? 657
What Features of the Examination Will Help to Achieve Diagnosis? 658
Is Additional Testing Necessary? 659
What Is the Treatment and How Do I Counsel the Patient? 659
CASE 4: A MAN WITH AN ACUTE ONSET OF SEVERE TREMOR DURING REST AND ACTION 660
Case Presentation 660
What Are the Key Features of the History Which Will Help Achieve the Diagnosis? 660
What Features of the Examination Will Help to Achieve the Diagnosis? 660
Is Additional Testing Necessary? 661
What Is the Treatment and How Do I Counsel the Patient? 661
CASE 5: TREMOR IN A WOMAN WITH COGNITIVE AND MOTOR DECLINE 661
Case Presentation 661
CLINICAL QUESTIONS 662
What Are the Key Features of the History Which Will Help Achieve the Diagnosis? 662
What Features of the Examination Will Help to Achieve the Diagnosis? 662
Is Additional Testing Necessary? 663
What Is the Treatment and How Do I Counsel the Patient? 663
SUPPLEMENTARY DATA 663
REFERENCES 664
Functional Disorders in Neurology 667
Key points 667
INTRODUCTION 667
CASE 1. JERKY BODY MOVEMENTS AFTER AN UNPLEASANT ANESTHETIC 668
What Is the Diagnosis and How is It Confirmed? 668
Investigation 669
Treatment 669
CASE 2. PERSISTENT AND DISABLING DIZZINESS IN A YOUNG WOMAN 670
What Is the Diagnosis? 670
Investigations 671
Treatment 671
CASE 3. NEW ONSET STUTTERING IN AN ADULT 671
What Is the Diagnosis? 672
Investigations and Workup 672
Treatment 673
CASE 4. FATIGUE, HEADACHE, AND COGNITIVE SYMPTOMS AFTER A MILD TRAUMATIC BRAIN INJURY 673
What Is the Diagnosis? 673
Treatment 674
CASE 5. TREATMENT OF DISSOCIATIVE (NONEPILEPTIC) ATTACKS OR SEIZURES 675
What Is the Diagnosis? 675
What Can Be Learned from Treatment? 675
CASE 6. TREATMENT OF FIXED DYSTONIA 677
What Is the Diagnosis? 677
What Can Be Learned from the Physiotherapy Approach in This Case? 678
SUPPLEMENTARY DATA 679
REFERENCES 679
Case Studies in Neurocritical Care 683
Key points 683
CASE 1: COMPLICATIONS AFTER A STROKE 684
Clinical Messages 686
CASE 2: EXTREME AGITATION IN AUTOIMMUNE ENCEPHALITIS 686
Clinical Messages 687
CASE 3: SEIZURES AFTER SUBDURAL HEMORRHAGE 688
Clinical Messages 688
CASE 4: COMPLICATIONS AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE 689
Clinical Messages 690
CASE 5: STATUS EPILEPTICUS AFTER CARDIAC ARREST 693
Clinical Messages 694
SUMMARY 694
REFERENCES 695
Case Studies Illustrating Focal Alzheimer’s, Fluent Aphasia, Late-Onset Memory Loss, and Rapid Dementia 699
Key points 699
INTRODUCTION 699
FOCAL CORTICAL PRESENTATIONS OF ALZHEIMER’S DISEASE 700
Posterior Cortical Atrophy 700
Clinical case 700
Clinical features 700
Pathophysiology 700
Corticobasal Syndrome 702
Clinical case 702
Clinical features 702
Pathophysiology 702
FLUENT APHASIA 703
Semantic Dementia 703
Clinical case 703
Clinical features 704
Pathophysiology 704
Logopenic Aphasia 705
Clinical case 705
Clinical features 705
Pathophysiology 705
LATE-ONSET DEMENTIA 706
Hippocampal Sclerosis 706
Clinical case 706
Clinical features compared with typical AD 707
Limbic-Predominant Alzheimer’s Disease 707
Clinical case 707
Clinical features 707
Pathophysiology 707
RAPIDLY PROGRESSIVE DEMENTIA 708
Creutzfeldt–Jakob Disease 708
Clinical case 708
Clinical features 709
Pathophysiology 709
Limbic Encephalitis 710
Clinical case 710
Clinical features 711
Pathophysiology 711
DISCUSSION 713
REFERENCES 713
Neurology of Pregnancy 717
Key points 717
PREGNANCY PHYSIOLOGY 717
CASE 1: ACUTE ISCHEMIC STROKE DURING PREGNANCY 718
Questions 718
Imaging During Pregnancy 718
Safety of Intravenous Tissue Plasminogen Activator in Pregnancy 718
Safety of Intra-Arterial Therapy in Pregnancy 719
Mechanisms of Stroke During Pregnancy 719
CASE 2: ECLAMPSIA 720
Questions 720
Definition of Preeclampsia/Eclampsia 720
Risks of Preeclampsia/Eclampsia 721
Pathophysiology 721
Management 723
CASE 3: REVERSIBLE VASOSPASM SYNDROME 723
Questions 723
Presentation 723
Pathophysiology 724
Precipitants 724
Management 724
CASE 4: MANAGEMENT OF MULTIPLE SCLEROSIS 724
Questions 724
Multiple Sclerosis Genetics 724
Medication Management 724
Effect of Pregnancy on Multiple Sclerosis 725
Breastfeeding 725
CASE 5: EPILEPSY 725
Questions 726
Teratogenicity Profiles of Antiepileptic Drugs 726
Maternal and Fetal Risks from Seizure During Pregnancy 726
Changes in Management of Antiepileptic Drugs During Pregnancy 726
CASE 6: FEMORAL NEUROPATHY 727
Questions 727
Incidence of Postpartum Lower Extremity Neuropathy 727
Causes of Femoral Neuropathy in the Postpartum Period 727
Prognosis 727
CASE 7: CARPAL TUNNEL SYNDROME 728
Questions 728
Incidence 728
How Is Carpal Tunnel Syndrome in Pregnancy Different? 728
Management of Carpal Tunnel Syndrome in Pregnancy 728
REFERENCES 728
Sports Neurology in Clinical Practice 733
Key points 733
CASE 1: SPORT-RELATED CONCUSSION AND ASSOCIATED HEADACHE 733
Discussion 734
Diagnosis 734
Treatment 735
CASE 2: CHRONIC TRAUMATIC ENCEPHALOPATHY 736
Discussion 736
Pathophysiology 737
Diagnosis 737
Comments 737
CASE 3: SPORT-RELATED HEADACHE 738
Discussion 738
Clinical Features 738
Pathophysiology 739
Differential Diagnosis 739
Treatment 740
CASE 4: THE NEUROLOGIC BENEFIT OF EXERCISE 740
Introduction 740
Background 740
Physiologic and Structural Changes 741
Discussion 742
REFERENCES 742
Neurological Fallacies Leading to Malpractice 747
Key points 747
CASE 1: MANAGEMENT OF THE INTRACRANIAL ARACHNOID CYST 748
Case Presentation 748
Questions 750
Discussion 750
Comments 750
What is an arachnoid cyst? 750
What symptoms are associated with arachnoid cysts? 750
Decompressive surgery for arachnoid cysts 751
Does decompressive cyst surgery help? 752
What about the neurologist? 752
Recommendations 752
CASE 2: NEUROIMAGING PATIENTS WITH ISOLATED HEADACHE 752
Case Presentation 752
Questions 753
Discussion 753
Background 753
Comments 753
Recommendations 757
CASE 3: THROMBOLYSIS FOR STROKE ON AWAKENING 757
Case Presentation 757
Questions 757
Discussion 757
Background 757
Comments 758
Recommendations 759
CASE 4: CEREBRAL PALSY, ELECTRONIC FETAL MONITORING, AND HYPOTHERMIA 760
Case Presentation 760
Question 760
Discussion 760
The records 760
The report 761
Cerebral palsy section 761
Electronic fetal monitoring section 762
Hypothermia section 763
Recommendations 763
SUMMARY 764
REFERENCES 764
Index 775