BOOK
Notes on Medical Microbiology E-Book
Katherine N. Ward | A. Christine McCartney | Bishan Thakker
(2014)
Additional Information
Book Details
Abstract
This completely rewritten, revised, and updated new edition provides an indispensable introduction to medical microbiology for students, trainee doctors and laboratory workers. Its contents cover advances in molecular microbiology especially for diagnostic techniques and include such topical subjects as MRSA, C. difficile, avian influenza and vCJD. The text is illustrated throughout with 130 illustrations most in full colour.
- Emphasises advances in molecular microbiology as applied to diagnostic techniques.
- Includes such topics as MRSA, C. difficile, avian influeza and vCJD.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Medical Microbiology | iii | ||
| Copyright Page | iv | ||
| Preface | v | ||
| Contents | vii | ||
| Chapter 1 Introduction to medical microbiology | 1 | ||
| NATURE OF MICROBIOLOGY | 1 | ||
| HISTORY OF MICROBIOLOGY | 2 | ||
| THE HOST–PARASITE RELATIONSHIP | 3 | ||
| NATURE OF EPIDEMIOLOGY | 7 | ||
| IMMUNIZATION | 9 | ||
| Part 1 Bacteria | 11 | ||
| Chapter 2 Bacteria – structure, taxonomy, nutrition, growth and genetics | 13 | ||
| STRUCTURE | 13 | ||
| TAXONOMY | 16 | ||
| NUTRITION AND GROWTH OF BACTERIA | 17 | ||
| BACTERIAL GENETICS | 21 | ||
| GENETIC VARIATION IN BACTERIA | 21 | ||
| Chapter 3 Laboratory diagnosis of bacterial diseases | 27 | ||
| SPECIMENS | 27 | ||
| TECHNIQUES USED IN LABORATORY INVESTIGATION | 28 | ||
| Chapter 4 Gram-positive bacteria including mycobacteria | 37 | ||
| GRAM-POSITIVE COCCI – STAPHYLOCOCCUS | 37 | ||
| GRAM-POSITIVE COCCI – STREPTOCOCCUS | 41 | ||
| GRAM-POSITIVE COCCI – ENTEROCOCCI | 47 | ||
| ANAEROBIC GRAM-POSITIVE COCCI – PEPTOCOCCCUS AND PEPTOSTREPTOCOCCUS | 48 | ||
| SPORING GRAM-POSITIVE BACILLI – BACILLUS ANTHRACIS AND OTHER SPECIES | 48 | ||
| NON-SPORING GRAM-POSITIVE BACILLI – LACTOBACILLUS | 50 | ||
| NON-SPORING GRAM-POSITIVE BACILLI – CORYNEBACTERIUM | 51 | ||
| NON-SPORING GRAM-POSITIVE BACILLI – PROPIONIBACTERIUM | 53 | ||
| NON-SPORING GRAM-POSITIVE BACILLI – ERYSIPELOTHRIX | 54 | ||
| NON-SPORING GRAM-POSITIVE BACILLI – LISTERIA | 54 | ||
| NON-SPORING BRANCHING GRAM-POSITIVE BACILLI – NOCARDIA | 55 | ||
| ANAEROBIC SPORING GRAM-POSITIVE BACILLI – CLOSTRIDIUM | 55 | ||
| NON-SPORING BRANCHING GRAM-POSITIVE BACILLI – ACTINOMYCES AND NOCARDIA | 60 | ||
| MYCOBACTERIUM | 62 | ||
| Chapter 5 Gram-negative bacteria | 66 | ||
| GRAM-NEGATIVE COCCI – NEISSERIA | 66 | ||
| GRAM-NEGATIVE COCCI – MORAXELLA | 69 | ||
| GRAM-NEGATIVE COCCI – ACINETOBACTER | 70 | ||
| GRAM-NEGATIVE COCCI – KINGELLA | 71 | ||
| GRAM-NEGATIVE ANAEROBIC COCCI – VEILLONELLA | 71 | ||
| GRAM-NEGATIVE BACILLI – PSEUDOMONAS, STENOTROPHOMONAS AND BURKHOLDERIA | 72 | ||
| GRAM-NEGATIVE BACILLI – ENTEROBACTERIA | 74 | ||
| GRAM-NEGATIVE BACILLI – PARVOBACTERIA | 82 | ||
| GRAM-NEGATIVE BACILLI – LEGIONELLA | 90 | ||
| GRAM-NEGATIVE BACILLI – VIBRIO, AEROMONAS, PLESIOMONAS, CAMPYLOBACTER AND HELICOBACTER | 90 | ||
| GRAM-NEGATIVE ANAEROBIC BACILLI – BACTEROIDES AND FUSOBACTERIUM | 95 | ||
| SPIROCHAETES | 96 | ||
| GRAM-NEGATIVE CELL-WALL DEFICIENT BACTERIA – MYCOPLASMA | 100 | ||
| GRAM-NEGATIVE OBLIGATE INTRACELLULAR BACTERIA | 102 | ||
| Chapter 6 Antibacterial therapy | 104 | ||
| GENERAL PROPERTIES OF ANTIBACTERIAL AGENTS | 104 | ||
| RESISTANCE TO ANTIBACTERIAL AGENTS | 105 | ||
| ANTIBACTERIAL AGENTS | 107 | ||
| PRINCIPLES OF ANTIBACTERIAL THERAPY | 122 | ||
| Part 2 Bacterial diseases | 127 | ||
| Chapter 7 Bacterial diseases of the respiratory tract | 129 | ||
| GENERAL PRINCIPLES | 129 | ||
| INFECTIONS OF THROAT AND PHARYNX | 129 | ||
| INFECTIONS OF MIDDLE EAR AND SINUSES | 136 | ||
| INFECTIONS OF TRACHEA AND BRONCHI | 138 | ||
| INFECTIONS OF THE LUNGS – PNEUMONIA | 143 | ||
| BACTERIAL CAUSES OF PNEUMONIA | 147 | ||
| OTHER INFECTIONS OF THE LUNGS | 151 | ||
| Chapter 8 Bacterial diseases acquired through the gastrointestinal tract | 153 | ||
| DIARRHOEA – GENERAL PRINCIPLES | 153 | ||
| COMMON BACTERIAL CAUSES OF DIARRHOEA | 154 | ||
| OTHER BACTERIAL CAUSES OF DIARRHOEA | 168 | ||
| FOOD- AND WATER-BORNE DISEASES MANIFESTING OUTSIDE THE GASTROINTESTINAL TRACT | 172 | ||
| GASTRITIS, PEPTIC ULCER AND GASTRIC CANCER | 175 | ||
| WHIPPLE’S DISEASE | 177 | ||
| Chapter 9 Enteric fever | 178 | ||
| Clinical features of typhoid fever | 178 | ||
| Clinical features of paratyphoid fever | 178 | ||
| Pathogenesis of typhoid fever | 179 | ||
| Epidemiology | 179 | ||
| Laboratory diagnosis | 180 | ||
| Prevention and treatment | 181 | ||
| Chapter 10 Urinary tract infections | 182 | ||
| Definitions | 182 | ||
| Causal organisms | 183 | ||
| Source, route and factors influencing urinary infection | 183 | ||
| Clinical features | 184 | ||
| Epidemiology | 184 | ||
| Prognosis | 185 | ||
| Laboratory diagnosis | 185 | ||
| Radiological investigations | 187 | ||
| Prevention | 187 | ||
| Treatments | 187 | ||
| Healthcare associated urinary tract infections | 188 | ||
| Chapter 11 Bacterial meningitis | 190 | ||
| BACTERIAL MENINGITIS – GENERAL PRINCIPLES | 190 | ||
| COMMON TYPES OF BACTERIAL MENINGITIS | 194 | ||
| RARER BACTERIAL MENINGITIDES | 198 | ||
| OTHER TYPES OF BACTERIAL MENINGITIS | 198 | ||
| Chapter 12 Skin, soft tissue and wound infections, abscesses, sepsis | 200 | ||
| SKIN INFECTIONS | 200 | ||
| CELLULITIS | 205 | ||
| NECROTIZING FASCIITIS | 206 | ||
| WOUND INFECTIONS | 207 | ||
| OTHER TYPES OF WOUND INFECTION | 210 | ||
| ABSCESSES | 214 | ||
| SEPSIS | 216 | ||
| Chapter 13 Infective endocarditis | 220 | ||
| Predisposing factors | 220 | ||
| Clinical features | 221 | ||
| Pathogenesis | 221 | ||
| Epidemiology | 222 | ||
| Clinical diagnosis | 222 | ||
| Laboratory diagnosis | 224 | ||
| Prevention and treatment | 225 | ||
| Chapter 14 Sexually transmitted diseases | 227 | ||
| GENERAL PRINCIPLES | 227 | ||
| SEXUALLY TRANSMITTED INFECTIONS CAUSING DISEASE IN BOTH SEXES | 229 | ||
| SEXUALLY TRANSMITTED INFECTIONS CAUSING DISEASE ONLY IN FEMALES | 237 | ||
| Chapter 15 Mycobacterial diseases including tuberculosis and leprosy | 241 | ||
| TUBERCULOSIS | 241 | ||
| TUBERCULOSIS IN HIV PATIENTS | 246 | ||
| LEPROSY (HANSEN’S DISEASE) | 247 | ||
| DISEASE DUE TO NON-TUBERCULOUS MYCOBACTERIA (NTM) | 249 | ||
| Chapter 16 Bone and joint infections: osteomyelitis and arthritis | 251 | ||
| OSTEOMYELITIS | 251 | ||
| ARTHRITIS | 254 | ||
| Chapter 17 Non-arthropod-borne bacterial zoonoses | 257 | ||
| ZOONOSES – GENERAL PRINCIPLES | 257 | ||
| NON-ARTHROPOD-BORNE BACTERIAL ZOONOSES | 257 | ||
| Chapter 18 Arthropod-borne bacterial diseases | 272 | ||
| ARTHROPOD-BORNE DISEASES – GENERAL PRINCIPLES | 272 | ||
| ARTHROPOD-BORNE BACTERIAL DISEASES | 272 | ||
| Part 3 Viruses | 281 | ||
| Chapter 19 Viruses – general properties, taxonomy, replication and genetics | 283 | ||
| GENERAL PROPERTIES | 283 | ||
| TAXONOMY | 286 | ||
| VIRUS REPLICATION | 286 | ||
| BIOCHEMISTRY OF VIRUS REPLICATION | 291 | ||
| VIRAL GENETICS | 304 | ||
| Chapter 20 Laboratory diagnosis of viral diseases | 306 | ||
| GENERAL PRINCIPLES | 306 | ||
| HOST ANTIBODY RESPONSE | 307 | ||
| DIRECT DEMONSTRATION OF VIRUS OR VIRUS COMPONENTS | 310 | ||
| VIRUS ISOLATION | 313 | ||
| Chapter 21 Antiviral therapy | 315 | ||
| GENERAL PROPERTIES OF ANTIVIRAL AGENTS | 315 | ||
| DRUGS ACTIVE AGAINST HERPESVIRUSES | 316 | ||
| DRUGS ACTIVE AGAINST RESPIRATORY VIRUSES | 321 | ||
| DRUGS ACTIVE AGAINST HEPATITIS VIRUSES | 322 | ||
| DRUGS ACTIVE AGAINST HIV | 323 | ||
| Part 4 Viral diseases | 327 | ||
| Chapter 22 Viral diseases of the respiratory tract | 329 | ||
| GENERAL PRINCIPLES | 329 | ||
| INFLUENZA | 329 | ||
| OTHER VIRAL DISEASES OF THE RESPIRATORY TRACT | 334 | ||
| Chapter 23 Viral gastroenteritis | 341 | ||
| GENERAL PRINCIPLES | 341 | ||
| ROTAVIRUS INFECTION | 343 | ||
| NOROVIRUS INFECTIONS | 345 | ||
| SAPOVIRUS INFECTIONS | 346 | ||
| ADENOVIRUS INFECTIONS | 346 | ||
| ASTROVIRUS INFECTIONS | 347 | ||
| OTHER VIRUS INFECTIONS | 347 | ||
| Chapter 24 Viral hepatitis | 348 | ||
| GENERAL PRINCIPLES | 348 | ||
| HEPATITIS A | 350 | ||
| HEPATITIS B | 352 | ||
| HEPATITIS C | 356 | ||
| HEPATITIS D | 358 | ||
| HEPATITIS E | 359 | ||
| Chapter 25 Viral neurological diseases | 360 | ||
| ACUTE VIRAL MENINGITIS AND ENCEPHALITIS | 360 | ||
| ACUTE POLYNEURITIS, ACUTE TRANSVERSE MYELITIS, POLIOMYELITIS | 362 | ||
| CHRONIC VIRAL NEUROLOGICAL DISEASES | 364 | ||
| Chapter 26 Enteroviral diseases | 365 | ||
| GENERAL PRINCIPLES | 365 | ||
| INFECTIONS OF THE CENTRAL NERVOUS SYSTEM (CNS) | 368 | ||
| NON-NEUROLOGICAL DISEASES | 369 | ||
| Chapter 27 Viral exanthemata and other ‘childhood diseases’ | 371 | ||
| CHILDHOOD RASH ILLNESS | 371 | ||
| OTHER ‘CHILDHOOD DISEASES’ | 377 | ||
| Chapter 28 Herpesvirus diseases | 380 | ||
| GENERAL CHARACTERISTICS OF THE HUMAN HERPESVIRUSES | 380 | ||
| VARICELLA-ZOSTER VIRUS INFECTIONS | 386 | ||
| CYTOMEGALOVIRUS INFECTIONS | 389 | ||
| HUMAN HERPESVIRUS 6 INFECTIONS | 391 | ||
| HUMAN HERPESVIRUS 7 INFECTIONS | 391 | ||
| EPSTEIN–BARR VIRUS INFECTIONS | 391 | ||
| KAPOSI’S SARCOMA-ASSOCIATED HERPESVIRUS INFECTIONS | 393 | ||
| Chapter 29 Papilloma- and polyomavirus infections and disease | 395 | ||
| PAPILLOMAVIRUSES AND DISEASE | 395 | ||
| POLYOMAVIRUSES AND DISEASE | 399 | ||
| Chapter 30 Retroviral diseases | 400 | ||
| HIV AND DISEASE | 400 | ||
| HTLV-1 AND DISEASE | 407 | ||
| HTLV-2 AND DISEASE | 409 | ||
| Chapter 31 Non-arthropod-borne viral zoonoses and poxvirus diseases | 410 | ||
| GENERAL PRINCIPLES | 410 | ||
| NON-ARTHROPOD-BORNE VIRAL ZOONOSES – VIRAL HAEMORRHAGIC FEVERS | 411 | ||
| NON-ARTHROPOD-BORNE VIRAL ZOONOSES – NEUROLOGICAL SYNDROMES | 415 | ||
| NON-ARTHROPOD-BORNE VIRAL ZOONOSES – POXVIRUS DISEASES | 420 | ||
| HUMAN POXVIRUSES AND DISEASE | 421 | ||
| Chapter 32 Arthropod-borne viral diseases | 423 | ||
| GENERAL PRINCIPLES | 423 | ||
| ARBOVIRUS HAEMORRHAGIC FEVERS | 425 | ||
| Part 5 Prion diseases | 431 | ||
| Chapter 33 Prion diseases – transmissible spongiform encephalopathies | 433 | ||
| GENERAL PRINCIPLES | 433 | ||
| HUMAN PRION DISEASES | 434 | ||
| PRION DISEASE IN ANIMALS | 437 | ||
| Part 6 Medical mycology | 439 | ||
| Chapter 34 Diseases due to fungi | 441 | ||
| GENERAL PRINCIPLES | 441 | ||
| DISEASES CAUSED BY FUNGI | 444 | ||
| YEAST INFECTIONS – CANDIDA | 446 | ||
| YEAST INFECTIONS – CRYPTOCOCCUS | 448 | ||
| YEAST INFECTIONS – MALASSEZIA | 449 | ||
| OTHER YEAST INFECTIONS | 450 | ||
| FILAMENTOUS FUNGAL INFECTIONS – DERMATOPHYTES | 450 | ||
| FILAMENTOUS FUNGAL INFECTIONS – ASPERGILLUS | 453 | ||
| FILAMENTOUS FUNGAL INFECTIONS – ZYGOMYCETES | 455 | ||
| INFECTIONS WITH EMERGING MOULD PATHOGENS | 455 | ||
| PNEUMOCYSTIS INFECTION | 456 | ||
| INFECTIONS WITH DIMORPHIC FUNGI | 456 | ||
| MYCETOMA | 458 | ||
| Part 7 Medical parasitology | 461 | ||
| Chapter 35 Diseases due to parasites | 463 | ||
| GENERAL PRINCIPLES | 463 | ||
| PARASITIC DISEASES ENCOUNTERED IN THE UK – BLOOD AND TISSUE INFECTIONS | 464 | ||
| PARASITIC DISEASES ENCOUNTERED IN THE UK – INTESTINAL AND UROGENITAL INFECTIONS | 474 | ||
| PARASITIC INTESTINAL DISEASE IN AIDS PATIENTS – DIARRHOEA | 476 | ||
| PARASITIC DISEASES NOT INDIGENOUS TO THE UK – MALARIA | 478 | ||
| PARASITIC DISEASES NOT INDIGENOUS TO THE UK – OTHER PROTOZOAL INFECTIONS | 481 | ||
| PARASITIC DISEASES NOT INDIGENOUS TO THE UK – HELMINTH INFECTIONS | 484 | ||
| Part 8 Prevention of microbial disease | 487 | ||
| Chapter 36 Sterilization and disinfection | 489 | ||
| GENERAL PRINCIPLES | 489 | ||
| STERILIZATION | 490 | ||
| Chapter 37 Healthcare-associated infection | 494 | ||
| CHAIN OF INFECTION | 495 | ||
| INFECTION CONTROL | 497 | ||
| Chapter 38 Immunization | 501 | ||
| GENERAL PRINCIPLES | 501 | ||
| ACTIVE IMMUNIZATION | 502 | ||
| TRAVEL ABROAD | 515 | ||
| PASSIVE IMMUNIZATION | 516 | ||
| Part 9 Infections in specialized settings | 519 | ||
| Chapter 39 Infections of the eye | 521 | ||
| CONJUNCTIVITIS | 521 | ||
| KERATITIS | 525 | ||
| ENDOPHTHALMITIS | 526 | ||
| CHOROIDITIS AND CHORIORETINITIS | 526 | ||
| PERIOCULAR INFECTIONS | 527 | ||
| Chapter 40 Pyrexia of unknown origin | 529 | ||
| CLASSICAL PUO | 529 | ||
| HEALTHCARE-ASSOCIATED POU | 533 | ||
| HIV-RELATED PUO | 533 | ||
| IMMUNOCOMPROMISE-RELATED PUO | 533 | ||
| Chapter 41 Infection in the immunocompromised | 534 | ||
| GENERAL PRINCIPLES | 534 | ||
| IMMUNE DEFECTS DUE TO DISEASE | 534 | ||
| IMMUNE DEFECTS DUE TO THERAPY | 535 | ||
| IMMUNE DEFECTS DUE TO AGE | 536 | ||
| CONGENITAL DEFICIENCIES OF THE IMMUNE SYSTEM | 536 | ||
| INFECTION IN THE IMMUNOCOMPROMISED | 537 | ||
| Chapter 42 Infection and pregnancy | 540 | ||
| GENERAL PRINCIPLES | 540 | ||
| MATERNAL VIRAL INFECTIONS | 541 | ||
| CONGENITAL VIRAL INFECTIONS | 541 | ||
| NEONATAL VIRUS INFECTIONS | 546 | ||
| MATERNAL BACTERIAL INFECTIONS | 550 | ||
| CONGENITAL BACTERIAL INFECTIONS | 550 | ||
| NEONATAL BACTERIAL INFECTIONS | 552 | ||
| CONGENITAL PARASITIC INFECTIONS | 555 | ||
| Recommended reading | 558 | ||
| Index | 559 |