BOOK
Soft Tissue Pathology: Diagnostic Challenges, An Issue of Surgical Pathology Clinics, E-Book
(2015)
Additional Information
Book Details
Abstract
This issue of Surgical Pathology Clinics is devoted to Soft Tissue Tumors, the first in this series was presented in 2011. This issue addresses the most difficult diagnostic challenges and focuses on differential diagnosis in soft tissue tumors. Each presentation is accompanied by abundant histologic slides to display the diagnostic differences. Additionally, authors selected two to five diagnoses they find can be particularly difficult, with an emphasis on how to approach such lesions on biopsy samples where relevant and the role of ancillary studies. Topics include coverage of diagnostically challenging: Vascular lesions; Retroperitoneal “Fatty tumors of adults; Smooth muscle neoplasms; Chondro-osseous lesions of soft tissue; Pediatric tumors; Epithelioid tumors; Spindle cell neoplasms of the retroperitoneum; and Peripheral nerve sheath tumors. Also presented are: Non-mesenchymal mimics of benign and malignant soft tissue tumors; Soft tissue tumors with overlapping molecular findings; Recently characterized soft tissue tumors; Benign mimics of sarcoma; Advances in molecular methods in the analysis of soft tissue tumors and therapeutic implications; and Myoepithelial tumors: an update. Leona Doyle and Karen Fritchie lead this issue of experts in soft tissue pathology.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Soft Tissue Pathology:\rDiagnostic Challenges\r | i | ||
| Copyright\r | ii | ||
| Contributors | iii | ||
| CONSULTING EDITOR | iii | ||
| EDITORS | iii | ||
| AUTHORS | iii | ||
| Contents | v | ||
| Preface: Diagnostic Challenges and Recent Developments in Soft Tissue Pathology\r | v | ||
| Diagnostically Challenging Epithelioid Soft Tissue Tumors\r | v | ||
| Diagnostically Challenging Epithelioid Vascular Tumors\r | v | ||
| Diagnostically Challenging Spindle Cell Neoplasms of the Retroperitoneum\r | v | ||
| Diagnostically Challenging “Fatty” Retroperitoneal Tumors\r | v | ||
| Selected Diagnostically Challenging Pediatric Soft Tissue Tumors\r | vi | ||
| Chondro-Osseous Lesions of Soft Tissue\r | vi | ||
| Myoepithelial Tumors: An Update\r | vi | ||
| The New Kids on the Block: Recently Characterized Soft Tissue Tumors\r | vi | ||
| Non-mesenchymal Mimics of Sarcoma\r | vii | ||
| Genetics of Gastrointestinal Stromal Tumors: A Heterogeneous Family of Tumors?\r | vii | ||
| Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications\r | vii | ||
| SURGICAL PATHOLOGY CLINICS\r | viii | ||
| FORTHCOMING ISSUES | viii | ||
| December 2015 | viii | ||
| March 2016 | viii | ||
| June 2016 | viii | ||
| RECENT ISSUES | viii | ||
| June 2015 | viii | ||
| March 2015 | viii | ||
| December 2014 | viii | ||
| Preface\r | ix | ||
| Diagnostically Challenging Epithelioid Soft Tissue Tumors | 309 | ||
| ABSTRACT | 309 | ||
| OVERVIEW | 309 | ||
| EPITHELIOID SARCOMA | 309 | ||
| GROSS FEATURES | 309 | ||
| MICROSCOPIC FEATURES | 310 | ||
| DIAGNOSIS | 311 | ||
| DIFFERENTIAL DIAGNOSIS | 311 | ||
| PROGNOSIS | 312 | ||
| ALVEOLAR SOFT PART SARCOMA | 313 | ||
| GROSS FEATURES | 313 | ||
| MICROSCOPIC FEATURES | 314 | ||
| DIAGNOSIS | 314 | ||
| DIFFERENTIAL DIAGNOSIS | 314 | ||
| PROGNOSIS | 316 | ||
| CLEAR-CELL SARCOMA | 317 | ||
| GROSS FEATURES | 317 | ||
| MICROSCOPIC FEATURES | 317 | ||
| DIAGNOSIS | 318 | ||
| DIFFERENTIAL DIAGNOSIS | 318 | ||
| PROGNOSIS | 318 | ||
| OSSIFYING FIBROMYXOID TUMOR | 319 | ||
| GROSS FEATURES | 319 | ||
| MICROSCOPIC FEATURES | 320 | ||
| DIAGNOSIS | 321 | ||
| DIFFERENTIAL DIAGNOSIS | 321 | ||
| PROGNOSIS | 322 | ||
| MALIGNANT EXTRARENAL RHABDOID TUMOR | 323 | ||
| GROSS FEATURES | 323 | ||
| MICROSCOPIC FEATURES | 323 | ||
| DIAGNOSIS | 324 | ||
| DIFFERENTIAL DIAGNOSIS | 324 | ||
| PROGNOSIS | 325 | ||
| ACKNOWLEDGMENTS | 325 | ||
| REFERENCES | 325 | ||
| Diagnostically Challenging Epithelioid Vascular Tumors | 331 | ||
| ABSTRACT | 331 | ||
| OVERVIEW | 331 | ||
| EPITHELIOID HEMANGIOMA | 331 | ||
| CUTANEOUS EPITHELIOID ANGIOMATOUS NODULE | 336 | ||
| EPITHELIOID HEMANGIOENDOTHELIOMA | 338 | ||
| EPITHELIOID SARCOMALIKE HEMANGIOENDOTHELIOMA (PSEUDOMYOGENIC HEMANGIOENDOTHELIOMA) | 342 | ||
| EPITHELIOID ANGIOSARCOMA | 346 | ||
| SUMMARY | 349 | ||
| REFERENCES | 349 | ||
| Diagnostically Challenging Spindle Cell Neoplasms of the Retroperitoneum | 353 | ||
| ABSTRACT | 353 | ||
| OVERVIEW | 353 | ||
| DEDIFFERENTIATED LIPOSARCOMA | 353 | ||
| INTRODUCTION | 353 | ||
| GROSS FEATURES | 354 | ||
| MICROSCOPIC FEATURES | 354 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 356 | ||
| PROGNOSIS | 357 | ||
| CELLULAR SCHWANNOMA | 357 | ||
| INTRODUCTION | 357 | ||
| GROSS FEATURES | 358 | ||
| MICROSCOPIC FEATURES | 358 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 358 | ||
| PROGNOSIS | 360 | ||
| MALIGNANT PERIPHERAL NERVE SHEATH TUMOR | 360 | ||
| INTRODUCTION | 360 | ||
| GROSS FEATURES | 361 | ||
| MICROSCOPIC FEATURES | 361 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 362 | ||
| PROGNOSIS | 363 | ||
| DEEP LEIOMYOMA | 364 | ||
| INTRODUCTION | 364 | ||
| GROSS FEATURES | 364 | ||
| MICROSCOPIC FEATURES | 364 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 364 | ||
| PROGNOSIS | 366 | ||
| LEIOMYOSARCOMA | 366 | ||
| INTRODUCTION | 366 | ||
| GROSS FEATURES | 367 | ||
| MICROSCOPIC FEATURES | 367 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 367 | ||
| PROGNOSIS | 369 | ||
| MAMMARY-TYPE MYOFIBROBLASTOMA | 369 | ||
| INTRODUCTION | 369 | ||
| GROSS FEATURES | 370 | ||
| MICROSCOPIC FEATURES | 370 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 370 | ||
| PROGNOSIS | 372 | ||
| SUMMARY | 372 | ||
| REFERENCES | 372 | ||
| Diagnostically Challenging “Fatty” Retroperitoneal Tumors | 375 | ||
| ABSTRACT | 375 | ||
| OVERVIEW | 375 | ||
| PATTERN 1: MATURE ADIPOSE TISSUE AND ATYPICAL HYPERCHROMATIC STROMAL CELLS | 376 | ||
| PATTERN 2: MATURE ADIPOSE TISSUE WITHOUT CYTOLOGIC ATYPIA | 380 | ||
| PATTERN 3: MATURE ADIPOSE TISSUE WITH ATYPICAL HYPERCHROMATIC STROMAL CELLS ADMIXED WITH UNDIFFERENTIATED PLEOMORPHIC SARCOMA | 381 | ||
| PATTERN 4: MATURE ADIPOSE TISSUE WITH LOW-GRADE SPINDLE-CELL PROLIFERATION | 385 | ||
| PATTERN 5: MYXOID SARCOMA WITH A FATTY COMPONENT | 389 | ||
| SUMMARY | 396 | ||
| REFERENCES | 396 | ||
| Selected Diagnostically Challenging Pediatric Soft Tissue Tumors | 399 | ||
| ABSTRACT | 399 | ||
| SUPERFICIAL EWING SARCOMA: OVERVIEW | 399 | ||
| GROSS FEATURES | 399 | ||
| MICROSCOPIC FEATURES | 399 | ||
| DIFFERENTIAL DIAGNOSIS | 400 | ||
| DIAGNOSIS | 404 | ||
| PROGNOSIS | 405 | ||
| POORLY DIFFERENTIATED CHORDOMA | 406 | ||
| OVERVIEW | 406 | ||
| GROSS FEATURES | 406 | ||
| MICROSCOPIC FEATURES | 406 | ||
| DIFFERENTIAL DIAGNOSIS | 406 | ||
| DIAGNOSIS | 409 | ||
| PROGNOSIS | 410 | ||
| NASAL CHONDROMESENCHYMAL HAMARTOMA | 411 | ||
| OVERVIEW | 411 | ||
| GROSS FEATURES | 413 | ||
| MICROSCOPIC FEATURES | 413 | ||
| DIFFERENTIAL DIAGNOSIS | 415 | ||
| DIAGNOSIS | 416 | ||
| PROGNOSIS | 416 | ||
| REFERENCES | 416 | ||
| Chondro-Osseous Lesions of Soft Tissue | 419 | ||
| ABSTRACT | 419 | ||
| OVERVIEW | 419 | ||
| MYOSITIS OSSIFICANS AND RELATED TUMORS | 420 | ||
| RADIOGRAPHIC FEATURES | 421 | ||
| GROSS FEATURES | 421 | ||
| MICROSCOPIC FEATURES | 421 | ||
| PROGNOSIS | 423 | ||
| GENETIC FEATURES | 423 | ||
| OSSIFYING FIBROMYXOID TUMOR | 423 | ||
| RADIOGRAPHIC FEATURES | 424 | ||
| GROSS FEATURES | 425 | ||
| MICROSCOPIC FEATURES | 426 | ||
| PROGNOSIS | 427 | ||
| GENETIC FEATURES | 427 | ||
| EXTRASKELETAL OSTEOSARCOMA | 427 | ||
| INTRODUCTION | 427 | ||
| RADIOGRAPHIC FEATURES | 428 | ||
| GROSS FEATURES | 428 | ||
| MICROSCOPIC FEATURES | 428 | ||
| PROGNOSTIC FEATURES | 429 | ||
| GENETIC FEATURES | 429 | ||
| SOFT TISSUE CHONDROMA | 431 | ||
| RADIOGRAPHIC FEATURES | 431 | ||
| GROSS FEATURES | 431 | ||
| MICROSCOPIC FEATURES | 431 | ||
| PROGNOSTIC FEATURES | 434 | ||
| GENETIC FEATURES | 434 | ||
| SYNOVIAL CHONDROMATOSIS | 435 | ||
| RADIOGRAPHIC FEATURES | 435 | ||
| GROSS FEATURES | 435 | ||
| MICROSCOPIC FEATURES | 435 | ||
| PROGNOSTIC FEATURES | 436 | ||
| GENETIC FEATURES | 436 | ||
| MESENCHYMAL CHONDROSARCOMA | 436 | ||
| RADIOGRAPHIC FEATURES | 436 | ||
| GROSS FEATURES | 438 | ||
| MICROSCOPIC FEATURES | 438 | ||
| PROGNOSTIC FEATURES | 439 | ||
| GENETIC FEATURES | 439 | ||
| EXTRASKELETAL MYXOID CHONDROSARCOMA | 439 | ||
| RADIOGRAPHIC FEATURES | 439 | ||
| GROSS FEATURES | 439 | ||
| MICROSCOPIC FEATURES | 440 | ||
| PROGNOSTIC FEATURES | 441 | ||
| GENETIC FEATURES | 441 | ||
| REFERENCES | 442 | ||
| Myoepithelial Tumors | 445 | ||
| ABSTRACT | 445 | ||
| The New Kids on the Block | 467 | ||
| ABSTRACT | 467 | ||
| OVERVIEW | 467 | ||
| SUPERFICIAL CD34-POSITIVE FIBROBLASTIC TUMOR | 467 | ||
| PATHOLOGIC FEATURES | 468 | ||
| DIFFERENTIAL DIAGNOSIS | 469 | ||
| FIBROSARCOMA-LIKE LIPOMATOUS NEOPLASM | 470 | ||
| PATHOLOGIC FEATURES | 470 | ||
| DIFFERENTIAL DIAGNOSIS | 470 | ||
| ANGIOFIBROMA OF SOFT TISSUE | 473 | ||
| PATHOLOGIC FEATURES | 473 | ||
| DIFFERENTIAL DIAGNOSIS | 475 | ||
| LOW-GRADE SINONASAL SARCOMA WITH NEURAL AND MYOGENIC FEATURES | 476 | ||
| PATHOLOGIC FEATURES | 476 | ||
| DIFFERENTIAL DIAGNOSIS | 479 | ||
| MALIGNANT GASTROINTESTINAL NEUROECTODERMAL TUMOR | 479 | ||
| PATHOLOGIC FEATURES | 480 | ||
| DIFFERENTIAL DIAGNOSIS | 480 | ||
| HEMOSIDEROTIC FIBROLIPOMATOUS TUMOR | 483 | ||
| PATHOLOGIC FEATURES | 483 | ||
| DIFFERENTIAL DIAGNOSIS | 483 | ||
| EPITHELIOID INFLAMMATORY MYOFIBROBLASTIC SARCOMA | 484 | ||
| PATHOLOGIC FEATURES | 486 | ||
| DIFFERENTIAL DIAGNOSIS | 488 | ||
| RECENT MOLECULAR FINDINGS IN SOFT TISSUE TUMORS | 489 | ||
| REFERENCES | 489 | ||
| Non-mesenchymal Mimics of Sarcoma | 493 | ||
| ABSTRACT | 493 | ||
| OVERVIEW | 493 | ||
| MALIGNANT MELANOMA | 493 | ||
| MELANOMA AND MALIGNANT PERIPHERAL NERVE SHEATH TUMOR | 495 | ||
| MELANOMA AND CLEAR CELL SARCOMA | 496 | ||
| METASTATIC MELANOMA WITH NO KNOWN PRIMARY | 496 | ||
| CARCINOMA TYPES THAT MAY MIMIC SARCOMA (AND VICE VERSA) | 497 | ||
| SARCOMATOID CARCINOMA OF BREAST | 497 | ||
| SARCOMATOID SQUAMOUS CELL CARCINOMA OF SKIN | 499 | ||
| RENAL CELL CARCINOMA, ADRENOCORTICAL CARCINOMA, AND MESENCHYMAL MIMICS | 502 | ||
| HEMATOLYMPHOID NEOPLASMS | 503 | ||
| ACUTE LYMPHOBLASTIC LYMPHOMA VERSUS ROUND CELL SARCOMA | 504 | ||
| HISTIOCYTIC SARCOMA | 506 | ||
| LYMPHOMA WITH SPINDLE CELL FEATURES | 506 | ||
| MALIGNANT MESOTHELIOMA | 511 | ||
| SUMMARY | 511 | ||
| REFERENCES | 511 | ||
| Genetics of Gastrointestinal Stromal Tumors | 515 | ||
| ABSTRACT | 515 | ||
| OVERVIEW | 515 | ||
| GENOTYPES OF GASTROINTESTINAL STROMAL TUMOR | 515 | ||
| KIT MUTATIONS | 515 | ||
| PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA MUTATIONS | 516 | ||
| FAMILIAL GASTROINTESTINAL STROMAL TUMOR SYNDROME | 518 | ||
| SO-CALLED KIT/PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA–WILD-TYPE GASTROINTESTINAL STROMAL TUMORS | 518 | ||
| SUCCINATE DEHYDROGENASE B–DEFICIENT GASTROINTESTINAL STROMAL TUMORS | 518 | ||
| CARNEY-STRATAKIS SYNDROME–RELATED GASTROINTESTINAL STROMAL TUMORS | 519 | ||
| CARNEY TRIAD–RELATED GASTROINTESTINAL STROMAL TUMORS | 519 | ||
| SPORADIC SUCCINATE DEHYDROGENASE–DEFICIENT GASTROINTESTINAL STROMAL TUMORS | 520 | ||
| BRAF-MUTATED GASTROINTESTINAL STROMAL TUMORS | 521 | ||
| NEUROFIBROMATOSIS TYPE 1-ASSOCIATED GASTROINTESTINAL STROMAL TUMORS | 522 | ||
| “QUADRUPLE WILD-TYPE” GASTROINTESTINAL STROMAL TUMORS | 522 | ||
| SUMMARY | 522 | ||
| REFERENCES | 522 | ||
| Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications | 525 | ||
| ABSTRACT | 525 | ||
| OVERVIEW | 525 | ||
| APPLICATIONS OF MASSIVELY PARALLEL SEQUENCING TECHNOLOGIES | 527 | ||
| MASSIVELY PARALLEL SEQUENCING (SO-CALLED NEXT-GENERATION SEQUENCING OR NGS) | 527 | ||
| CANCER GENOME SEQUENCING | 528 | ||
| TARGETED SEQUENCING (CANCER GENE PANELS AND EXOME SEQUENCING) | 529 | ||
| WHOLE GENOME SEQUENCING (WGS) | 530 | ||
| TRANSCRIPTOME SEQUENCING (RNA-SEQ) | 531 | ||
| NON–SEQUENCING-BASED HIGH-THROUGHPUT MOLECULAR TECHNIQUES | 532 | ||
| ARRAY-BASED TECHNOLOGIES | 532 | ||
| LOW-THROUGHPUT TECHNOLOGIES | 532 | ||
| SINGLE GENE SEQUENCING ASSAYS | 532 | ||
| FLUORESCENCE IN SITU HYBRIDIZATION | 532 | ||
| IMMUNOHISTOCHEMISTRY AS A SURROGATE FOR MOLECULAR ALTERATIONS | 533 | ||
| DRUG TARGET IDENTIFICATION | 533 | ||
| CONCLUDING REMARKS | 534 | ||
| REFERENCES | 534 |