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The Pediatric Cerebellum, An Issue of Neuroimaging Clinics of North America, E-Book

The Pediatric Cerebellum, An Issue of Neuroimaging Clinics of North America, E-Book

Thierry A. G. M. Huisman | Andrea Poretti

(2016)

Additional Information

Abstract

This issue of Neuroimaging Clinics of North America focuses on The Pediatric Cerebellum, and is edited by Drs. Huisman and Andrea Poretti. Articles will include: The role of the pediatric cerebellum in motor functions, neurocognition and behavior: a clinical perspective; Normal development of the cerebellum: from the fetus to the adolescent; Cerebellar malformations; Cerebellar disruptions; Metabolic disorders with cerebellar involvement; Neurocutaenous syndromes with cerebellar involvement; Vascular disorders of the cerebellum; Tumors of the cerebellum; Infectious and inflammatory diseases of the cerebellum; Cerebro-cerebellar network, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
The Pediatric\rCerebellum i
Copyright ii
CME Accreditation Page iii
PROGRAM OBJECTIVE iii
TARGET AUDIENCE iii
LEARNING OBJECTIVES iii
ACCREDITATION iii
DISCLOSURE OF CONFLICTS OF INTEREST iii
UNAPPROVED/OFF-LABEL USE DISCLOSURE iii
TO ENROLL iii
METHOD OF PARTICIPATION iii
CME INQUIRIES/SPECIAL NEEDS iii
NEUROIMAGING CLINICS OF NORTH AMERICA iv
FORTHCOMING ISSUES iv
November 2016 iv
February 2017 iv
May 2017 iv
RECENT ISSUES iv
May 2016 iv
February 2016 iv
November 2015 iv
Contributors v
CONSULTING EDITOR v
EDITORS v
AUTHORS v
Contents vii
Foreword: The Pediatric Cerebellum vii
Preface: The Pediatric Cerebellum vii
The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior: A Clinical Perspective vii
Normal Cerebellar Development by Qualitative and Quantitative MR Imaging: From the Fetus to the Adolescent vii
Cerebellar and Brainstem Malformations vii
Prenatal Cerebellar Disruptions: Neuroimaging Spectrum of Findings in Correlation with Likely Mechanisms and Etiologies of ... vii
The Pediatric Cerebellum in Inherited Neurodegenerative Disorders: A Pattern-recognition Approach viii
Pediatric Neurocutaneous Syndromes with Cerebellar Involvement viii
Vascular Disorders of the Cerebellum in Children viii
Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features viii
Neuroimaging of Infectious and Inflammatory Diseases of the Pediatric Cerebellum and Brainstem ix
Foreword:\rThe Pediatric Cerebellum xi
Preface:\rThe Pediatric Cerebellum xiii
REFERENCES xiv
The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior 317
Key points 317
INTRODUCTION 317
LIMBS MOTOR CONTROL 318
OCULAR MOTOR CONTROL 318
SPEECH CONTROL 319
A ROLE BEYOND MOTOR SYSTEMS 321
LANGUAGE 321
COGNITION 322
BEHAVIOR 322
Attention Deficit Hyperactivity Disorder 322
Schizophrenia 323
Autism Spectrum Disorders 323
Other Disorders 324
SUMMARY 324
REFERENCES 324
Normal Cerebellar Development by Qualitative and Quantitative MR Imaging 331
Key points 331
INTRODUCTION 331
EMBRYOLOGIC DEVELOPMENT OF THE CEREBELLUM 332
IN VIVO STRUCTURAL DEVELOPMENT OF THE CEREBELLUM BY CONVENTIONAL MR IMAGING 332
IN VIVO CEREBELLAR VOLUMETRIC AND SHAPE DEVELOPMENT OBSERVED BY QUANTITATIVE MR IMAGING 333
CEREBELLAR MICROSTRUCTURE ORGANIZATION OBSERVED BY DIFFUSION TENSOR IMAGING 334
CEREBELLAR MYELINATION DESCRIBED BY CONVENTIONAL AND QUANTITATIVE MR IMAGING 335
CEREBELLAR FUNCTIONAL NETWORK ORGANIZATION AND DEVELOPMENT OBSERVED BY FUNCTIONAL MR IMAGING 336
CEREBELLAR METABOLITE PROFILES DESCRIBED BY PROTON SPECTROSCOPY 337
SUMMARY 338
ACKNOWLEDGMENTS 338
REFERENCES 338
Cerebellar and Brainstem Malformations 341
Key points 341
INTRODUCTION 341
NORMAL ANATOMY OF THE POSTERIOR FOSSA 342
PREDOMINANTLY CEREBELLAR MALFORMATIONS 343
Dandy-Walker Malformation 343
Rhombencephalosynapsis 345
Cerebellar Dysplasia and Cerebellar Cysts 345
CEREBELLAR AND BRAINSTEM MALFORMATIONS 347
Pontocerebellar Hypoplasia 347
Congenital Muscular Dystrophies Caused by Defective Alpha-dystroglycan Glycosylation 350
Tubulinopathies 350
Joubert Syndrome 351
PREDOMINANT BRAINSTEM MALFORMATIONS 352
Pontine Tegmental Cap Dysplasia 352
Horizontal Gaze Palsy with Progressive Scoliosis 353
Brainstem disconnection 355
Diencephalic-mesencephalic junction dysplasia 355
SUMMARY 355
REFERENCES 355
Prenatal Cerebellar Disruptions 359
Key points 359
INTRODUCTION 359
CEREBELLAR AGENESIS 361
GLOBAL CEREBELLAR HYPOPLASIA 363
UNILATERAL CEREBELLAR HYPOPLASIA 364
CEREBELLAR CLEFT 368
VANISHING CEREBELLUM IN CHIARI II MALFORMATION 369
SUMMARY 369
REFERENCES 370
The Pediatric Cerebellum in Inherited Neurodegenerative Disorders 373
Key points 373
INTRODUCTION 373
NEUROIMAGING PATTERN COMPONENTS IN THE CEREBELLUM 374
BIOMETRY 374
DIFFERENTIATING INHERITED AND ACQUIRED DISORDERS WITH CEREBELLAR INVOLVEMENT 375
CEREBELLOVERMIAN VOLUME LOSS: HYPOPLASIA VERSUS ATROPHY 375
CEREBELLAR ATROPHY, GENERAL 378
ISOLATED CEREBELLAR ATROPHY 379
GRADIENTS OF VOLUME LOSS ADD FURTHER SPECIFICITY 380
AUTOSOMAL RECESSIVE SPASTIC ATAXIA OF CHARLEVOIX-SAGUENAY; A DISORDER WITH SIGNIFICANT ANTERIOR VERMIAN ATROPHY 382
ABNORMALITIES OF CEREBELLAR PEDUNCLE AND BRAINSTEM VOLUME 383
FOCAL ABNORMALITIES OF BRAINSTEM BIOMETRY 384
CONGENITAL DISORDER OF GLYCOSYLATION CDG1A (PMM2): THE PROTOTYPE FOR DISORDERS WITH PONTINE (AND CEREBELLAR) ATROPHY 385
ATROPHY OF THE SPINAL CORD, GENERAL 387
FRIEDREICH ATAXIA IS THE PROTOTYPE FOR NEURODEGENERATIVE DISORDERS WITH PREDOMINANT SPINAL CORD ATROPHY 387
ADDITIONAL IMAGING FEATURES: FOCI OF MAGNETIC SUSCEPTIBILITY IN ATAXIA TELANGIECTASIA (AND OTHERS) 389
ADDITIONAL IMAGING FINDINGS: CYSTS 390
ADDITIONAL IMAGING FINDINGS: CEREBELLAR ATROPHY WITH INCREASED CEREBELLAR CORTEX SIGNAL ON FLUID-ATTENUATED INVERSION RECOVERY 391
DENTATE NUCLEI 395
DENTATE NUCLEI AND CEREBELLAR WHITE MATTER 396
CEREBELLAR WHITE MATTER, INCLUDING THE BRIGHT MIDDLE CEREBELLAR PEDUNCLE SIGN 398
CEREBELLAR WHITE MATTER IN SELECTED MITOCHONDRIAL DISORDERS 401
ADDITIONAL IMAGING FEATURES: DIFFUSION RESTRICTION 403
ADDITIONAL IMAGING FEATURES: ENHANCEMENT FOLLOWING CONTRAST ADMINISTRATION 405
MAGNETIC RESONANCE SPECTROSCOPY 407
REFERENCES 411
Pediatric Neurocutaneous Syndromes with Cerebellar Involvement 417
Key points 417
INTRODUCTION 417
NEUROFIBROMATOSIS TYPE 1 417
TUBEROUS SCLEROSIS COMPLEX 419
STURGE-WEBER SYNDROME 420
PHACE SYNDROME 421
VON HIPPEL-LINDAU DISEASE 421
NEUROCUTANEOUS MELANOSIS 424
GÓMEZ-LÓPEZ-HERNÁNDEZ SYNDROME 424
ENCEPHALOCRANIOCUTANEOUS LIPOMATOSIS 424
OCULOCEREBROCUTANEOUS SYNDROME 427
EPIDERMAL NEVUS SYNDROME 427
PTEN HAMARTOMA TUMOR SYNDROME 427
BASAL CELL NEVUS SYNDROME 428
COCKAYNE SYNDROME 429
TRICHOTHIODYSTROPHY 431
COSTELLO SYNDROME 431
SUMMARY 432
REFERENCES 432
Vascular Disorders of the Cerebellum in Children 435
Key points 435
INTRODUCTION 435
DEVELOPMENT OF THE CEREBELLAR AND BRAINSTEM ARTERIAL SUPPLY 436
Anatomic Variations 437
Persistent Caroticovertebral Connections 437
VENOUS DEVELOPMENT AND DRAINAGE OF THE CEREBELLUM AND BRAINSTEM 437
Superficial Veins of the Cerebellum 437
Deep Veins of the Cerebellum 442
Veins of the Brainstem 442
Bridging Veins 442
VASCULAR LESIONS OF THE CEREBELLUM AND BRAINSTEM 442
Cavernous Malformations 442
Imaging findings 444
Computed tomography 444
MR imaging 444
Developmental Venous Anomalies 445
Imaging findings 447
Computed tomography 448
MR Imaging 448
Catheter angiography 448
Posterior Fossa Capillary Telangiectasias 448
Imaging findings 449
Computed tomography 449
MR Imaging 449
Posterior Fossa Arteriovenous Malformations and Arteriovenous Fistulae 451
Imaging features 451
Computed tomography, MR imaging, and catheter angiography 451
Considerations and associations 454
Multifocal niduses 454
Posterior Fossa Aneurysms in Children 454
Aneurysm location 455
Imaging characteristics 456
Computed tomography, MR imaging, magnetic resonance angiography, and catheter angiography 456
SUMMARY 457
REFERENCES 457
Pediatric Cerebellar Tumors 459
Key points 459
INTRODUCTION 459
TUMOR TYPES 459
PILOCYTIC ASTROCYTOMA 460
MEDULLOBLASTOMA 461
EPENDYMOMA 462
ATYPICAL TERATOID RHABDOID TUMOR 464
OTHER ENTITIES 464
Ganglioglioma 464
Infiltrating Glioma 464
Radiation-Induced Glioma 464
Metastatic Disease 465
Syndromic-Associated Tumors 465
Tumor Mimicking Conditions 465
Imaging Considerations 465
Intraoperative MR Imaging 466
TREATMENT AND MANAGEMENT CONSIDERATIONS 466
Radiation 466
Posterior Fossa Syndrome 467
SUMMARY 467
REFERENCES 467
Neuroimaging of Infectious and Inflammatory Diseases of the Pediatric Cerebellum and Brainstem 471
Key points 471
INTRODUCTION 471
NEUROIMAGING: GENERAL PRINCIPLES 472
ACUTE CEREBELLITIS 473
ACUTE POSTINFECTIOUS CEREBELLAR ATAXIA 475
ACUTE DISSEMINATED ENCEPHALOMYELITIS 475
MULTIPLE SCLEROSIS 475
ACUTE NECROTIZING ENCEPHALOPATHY 476
OPSOCLONUS-MYOCLONUS SYNDROME 478
PYOGENIC ABSCESS 479
TUBERCULOSIS 479
FUNGAL INFECTIONS 479
CYSTICERCOSIS 482
CONGENITAL INFECTIONS 483
RHOMBENCEPHALITIS (BRAINSTEM ENCEPHALITIS) 483
SUMMARY 486
REFERENCES 486
Index 489