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Current Controversies in Thoracic Surgery, An Issue of Thoracic Surgery Clinics of North America, E-Book

Current Controversies in Thoracic Surgery, An Issue of Thoracic Surgery Clinics of North America, E-Book

Michael Lanuti

(2016)

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Book Details

Abstract

This issue of Thoracic Surgery Clinics of North America, guest edited by Dr. Michael Lanuti, is devoted to Current Controversies in Thoracic Surgery. Dr. Lanuti has assembled expert authors to review the following topics: Management of Stage IIIA Non-Small Cell Lung Cancer; Management of Oligometastatic Non-Small Cell Lung Cancer; Current Treatment of Mesothelioma (Extrapleural Pneumonectomy or Pleurectomy); Stents as Primary Therapy for Esophageal Perforation; Lymph Node Dissection and Pulmonary Metastectomy; Mediastinal Staging: Endobronchial Ultrasound or Mediastinoscopy; Induction Therapy for Esophageal Cancer; Appropriate Surgical Treatment of Stage I Non-Small Cell Lung Cancer; Stereotactic Body Radiotherapy for Stage I Non-Small Cell Lung Cancer; Benefit of Plication for Paralyzed Diaphragm; Video-assisted Thoracoscopic Surgery (VATS) Sympathectomy for Hyperhidrosis; Induction Therapy for Thymoma, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Current Controversies in\rThoracic Surgery i
Copyright ii
Contributors iii
CONSULTING EDITOR iii
EDITOR iii
AUTHORS iii
Contents v
Preface: Managing Controversial Issues in Thoracic Surgery v
Mediastinal Staging: Endosonographic Ultrasound Lymph Node Biopsy or Mediastinoscopy v
Sublobar Resection: Ongoing Controversy for Treatment for Stage I Non–Small Cell Lung Cancer v
Stereotactic Body Radiation Therapy for Stage I Non–Small Cell Lung Cancer v
Management of Stage IIIA (N2) Non–Small Cell Lung Cancer v
Surgical Management of Oligometastatic Non–Small Cell Lung Cancer vi
The Role of Induction Therapy for Esophageal Cancer vi
The Evolution and Current Utility of Esophageal Stent Placement for the Treatment of Acute Esophageal Perforation vi
Lymph Node Dissection and Pulmonary Metastasectomy vi
Induction Therapy for Thymoma vii
Best Approach and Benefit of Plication for Paralyzed Diaphragm vii
Video-Assisted Thoracic Sympathectomy for Hyperhidrosis vii
Current Treatment of Mesothelioma: Extrapleural Pneumonectomy Versus Pleurectomy/Decortication vii
THORACIC SURGERY CLINICS viii
FORTHCOMING ISSUES viii
November 2016 viii
February 2017 viii
May 2017 viii
RECENT ISSUES viii
May 2016 viii
February 2016 viii
November 2015 viii
Preface:\rManaging Controversial Issues in Thoracic Surgery ix
Mediastinal Staging 243
Key points 243
INTRODUCTION 243
WHY DO WE STAGE IN NON–SMALL CELL LUNG CANCER? 244
IN WHOM DO WE INVASIVELY STAGE THE MEDIASTINUM IN NON–SMALL CELL LUNG CANCER? 244
WHO DOES NOT NEED INVASIVE MEDIASTINAL STAGING IN NON–SMALL CELL LUNG CANCER? 244
WHAT IS AN IDEAL GOLD STANDARD TEST IN STAGING LUNG CANCER? 244
ENDOSONOGRAPHIC ULTRASOUND (COMBINED ENDOBRONCHIAL ULTRASOUND–ENDOSCOPIC ULTRASOUND), LYMPH NODE BIOPSY, OR MEDIASTINOSCOPY? 244
Lymph Node Access, Sensitivity, Accuracy, and Negative Predictive Value 244
Complication Rate 246
Cost 247
Restaging After Neoadjuvant Chemoradiation 247
Aortopulmonary Window Lymph Nodes 247
SUMMARY 247
REFERENCES 247
Sublobar Resection 251
Key points 251
HISTORY 251
PROSPECTIVE RANDOMIZED TRIALS 252
POPULATION-BASED ANALYSIS 252
RETROSPECTIVE ANALYSIS 252
FACTORS EFFECTING OUTCOME 255
Tumor Size 255
Surgical Margin 255
Segmentectomy 255
SPECIAL CONSIDERATIONS 256
The Elderly Patient 256
Ground Glass Nodules 257
SUMMARY 257
REFERENCES 257
Stereotactic Body Radiation Therapy for Stage I Non–Small Cell Lung Cancer 261
Key points 261
INTRODUCTION 261
MEDICALLY INOPERABLE PATIENTS 262
Development of Stereotactic Body Radiation Therapy Technique 262
Prospective Collaborative Trials 262
MEDICALLY OPERABLE PATIENTS 263
Retrospective Experience 263
Prospective Phase II Trials 264
Randomized Phase III Trials 264
Large Database Analyses 264
TOXICITY CONSIDERATIONS WITH STEREOTACTIC BODY RADIATION THERAPY 265
Skin and Chest Wall/Rib 265
Central Location 265
Pulmonary Toxicity 266
OPTIMAL STEREOTACTIC BODY RADIATION THERAPY DOSE 266
SUMMARY 268
REFERENCES 268
Management of Stage IIIA (N2) Non–Small Cell Lung Cancer 271
Key points 271
BACKGROUND 271
STAGING CONSIDERATIONS 271
Accurate Determination of IIIA (N2) Non–Small Cell Lung Cancer 271
Initial Staging 272
How Do Endobronchial Ultrasound and Mediastinoscopy Compare? 272
Occult N2 Disease 272
Is Restaging Necessary After Neoadjuvant Therapy? 272
Who Can Tolerate a Multimodality Treatment Regimen? 273
THE EVOLUTION OF MULTIMODALITY TREATMENT FOR LOCALLY ADVANCED LUNG CANCER 273
Radiation Dosage in the Neoadjuvant Setting 274
Phase II Trials of Neoadjuvant Concurrent Chemoradiation 274
Intergroup 0139–Definitive or Just Old News? 274
EVOLUTION OF TREATMENT IN THE MODERN ERA: INTERGROUP 0139 AFTERMATH 275
The Role of Surgery 275
Who Should be Considered for Surgery: Not All N2 Is Created Equally 275
Is Surgery Safe After Neoadjuvant Chemoradiation to 60 Gy? 275
Outcomes of Surgery for Stage IIIA (N2) 276
Specific Surgical Considerations 276
Persistent N2 disease 276
Incidentally discovered N2 277
Is a pneumonectomy really too dangerous to be considered after radiation therapy? 277
Unresolved Issues in Treating IIIA (N2) Disease: Chemotherapy 277
Adjuvant versus neoadjuvant prescription 277
Major studies evaluating adjuvant chemotherapy 278
Adjuvant chemotherapy for patients who have received neoadjuvant therapy 278
Targeted therapy in IIIA (N2) regimens 279
UNRESOLVED ISSUES: RADIATION 279
Neoadjuvant Radiation Dose 279
More Is Not Always Better 279
Is Neoadjuvant Radiation the Right Paradigm to Follow? 279
Revisiting Postoperative Radiation Therapy 280
Evolving Radiation Therapy 281
THE FUTURE---MORE COMPLICATED, NOT LESS 281
Proton Beam Therapy 281
Immunotherapy 281
Targeted Therapy 281
SUMMARY 281
Evidence-based Treatment Regimens for Potentially Resectable IIIA (N2) Disease 281
What Can Be Said Definitively from the Literature? 282
Ongoing Challenges in Studying Stage IIIA (N2) Disease 282
Final Statement 282
REFERENCES 282
Surgical Management of Oligometastatic Non–Small Cell Lung Cancer 287
Key points 287
INTRODUCTION 287
DEFINITION OF OLIGOMETASTATIC DISEASE 288
PRINCIPLES OF SURGICAL TREATMENT 288
ORGAN-SPECIFIC CONSIDERATIONS 289
Solitary Brain Metastasis 289
Solitary Adrenal Metastases 290
Other Organs 291
OUTCOMES 291
SUMMARY 292
REFERENCES 293
The Role of Induction Therapy for Esophageal Cancer 295
Key points 295
INTRODUCTION 295
ROLE OF INDUCTION THERAPY 296
Induction Chemotherapy 298
Induction Chemoradiation 299
Induction Chemotherapy Versus Induction Chemoradiation 300
SELECTING THERAPY 301
SUMMARY 301
REFERENCES 301
The Evolution and Current Utility of Esophageal Stent Placement for the Treatment of Acute Esophageal Perforation 305
Key points 305
INTRODUCTION 305
HISTORY 305
EARLY IMPLEMENTATION 306
CURRENT STATE 308
Exclusion Criteria 308
Stent Placement Technique 308
Outcomes 312
REFERENCES 313
Lymph Node Dissection and Pulmonary Metastasectomy 315
Key points 315
INTRODUCTION 315
INTRATHORACIC LYMPH NODE INVOLVEMENT AND ISOLATED PULMONARY METASTASIS BY PRIMARY TUMOR HISTOLOGY 316
Colorectal Carcinoma 316
Renal Cell Carcinoma 317
Sarcoma 318
Germ Cell Tumors 318
Melanoma 319
Head and Neck Squamous Cell Carcinoma 319
Breast Carcinoma 319
Incidence and Prognostic Value of Nodal Status by Histology 320
DOES N1 VERSUS N2 LYMPH NODE DISEASE MATTER? 320
DOES MEDIASTINAL LYMPHADENECTOMY IMPROVE SURVIVAL? 320
WHICH PATIENTS SHOULD UNDERGO MEDIASTINAL LYMPH NODE DISSECTION? 321
REFERENCES 321
Induction Therapy for Thymoma 325
Key points 325
INTRODUCTION 325
GENERAL APPROACH TO THE TREATMENT OF LOCALLY ADVANCED THYMIC TUMORS 325
INDUCTION CHEMOTHERAPY IN THYMOMA 326
INDUCTION CHEMORADIATION IN THYMOMA 328
INDUCTION RADIATION IN THYMOMA 330
SPECIAL CONSIDERATIONS WITH STAGE IVA DISEASE 330
ROLE OF TARGETED THERAPIES 330
WHAT IS THE ACTUAL BENEFIT OF INDUCTION THERAPY? 331
REFERENCES 331
Best Approach and Benefit of Plication for Paralyzed Diaphragm 333
Key points 333
INTRODUCTION 333
Diaphragmatic Eventration and Diaphragmatic Paralysis 333
PATHOPHYSIOLOGY AND CLINICAL PRESENTATION 334
DIAGNOSIS AND PREOPERATIVE EVALUATION 334
Symptom Evaluation 334
Objective Respiratory and Quality of Life Evaluation 334
Physical Examination 334
Pulmonary Function Tests 334
Imaging Studies 335
Chest radiograph 335
Fluoroscopic sniff test 335
Ultrasound 335
Computerized tomography 335
Other Diagnostic Tests 335
SURGICAL TREATMENT 335
Diaphragmatic Plication 335
Indications 336
Contraindications 336
Surgical Approaches 336
Open transthoracic plication 336
Thoracoscopic video-assisted thoracoscopic surgery and robotic-assisted plication 337
Open transabdominal plication 337
Laparoscopic plication 338
Laparoscopic Diaphragm Plication Surgical Technique 338
Anesthesia 338
Position 338
Ports 340
Suture material 340
Procedure steps 340
Exposure 340
Controlled pneumothorax 340
Posterior plication 340
Anterior plication 340
Tube thoracostomy 342
Lung reexpansion 342
Postoperative care 342
Complications of diaphragm plication 342
REHABILITATION AND RECOVERY 344
Comparison of Surgical Approaches for Diaphragm Plication 344
SUMMARY 344
REFERENCES 344
Video-Assisted Thoracic Sympathectomy for Hyperhidrosis 347
Key points 347
INTRODUCTION 347
PRIMARY OR IDIOPATHIC HYPERHIDROSIS 348
Palmar Hyperhidrosis 348
Plantar Hyperhidrosis 348
Axillary Hyperhidrosis 349
Cranial-Facial Hyperhidrosis 349
THORACIC SYMPATHECTOMY 349
General Anesthesia 350
Positioning 350
Instruments 350
Technique 350
TARGET GANGLIA 351
Palmar Hyperhidrosis 351
Axillary Hyperhidrosis 352
Cranial-facial Hyperhidrosis and/or Flushing 352
Plantar Hyperhidrosis 352
ALTERNATIVES TO SYMPATHECTOMY 352
CLINICAL TREATMENT WITH OXIBUTININ 353
QUALITY OF LIFE VERSUS PRIMARY HYPERHIDROSIS 353
RESULTS OF VIDEO-ASSISTED THORACIC SYMPATHECTOMY 354
DIFFICULTIES AND TECHNICAL COMPLICATIONS 355
Pleural Adherences 355
The Azygous Lobe 355
Significant Hemorrhage 355
Chylothorax 355
Pneumothorax 355
Subcutaneous Emphysema 355
Pulmonary Atelectasis 355
Transitory Brachycardia 356
Postoperative Pain 356
Paresis and Paresthesia 356
Horner Syndrome 356
Contraindications 356
REASONS FOR VIDEO-ASSISTED THORACIC SYMPATHECTOMY FAILURE 356
Incomplete Surgery 356
Regeneration 357
Functional Reorganization 357
REFERENCES 357
Current Treatment of Mesothelioma 359
Key points 359
INTRODUCTION 359
THE CASE FOR SURGERY IN TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA 360
OPTIONS FOR SURGERY 360
Extrapleural Pneumonectomy 360
Preoperative evaluation for extrapleural pneumonectomy 360
Extrapleural pneumonectomy perioperative management 361
Extrapleural pneumonectomy surgical technique 361
Extrapleural pneumonectomy postoperative care 362
Extrapleural pneumonectomy results 362
Pleurectomy Decortication 363
Pleurectomy decortication preoperative evaluation 363
Pleurectomy decortication perioperative management 364
Pleurectomy decortication surgical technique 364
Pleurectomy decortication postoperative care 364
Pleurectomy decortication results 365
DATA COMPARING EXTRAPLEURAL PNEUMONECTOMY WITH PLEURECTOMY DECORTICATION 365
SUMMARY 372
REFERENCES 372
Index 377