Additional Information
Book Details
Abstract
Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Breast, second edition, is a visually stunning, easy-to-use reference covering all aspects of breast pathology. Outstanding images, including gross and microscopic pathology, a wide range of supportive immunohistochemistry, and detailed medical illustrations with numerous examples of morphologic findings, make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.
- Thoroughly updated content throughout , including coverage of new technologies and molecular approaches that are quickly moving out of the laboratory into clinical diagnosis and therapeutic decision making
- New to this edition: Tips on how to biopsy and send the best block for breast cancer predictive factor testing, updated prognostic assays, updated national guidelines (including HER2 testing) with photos, neoadjuvant treatment, new drugs for HER2-positive cancers, and pattern-based differential diagnosis chapters and guidance on the most helpful IHC antibodies
- For each anatomical site, you will find CAP cancer staging and specimen handling protocols, plus detailed immunohistochemistry panels to accompany the images
- High-quality, carefully annotated color images provide clinically and diagnostically important information
- Fully integrated, searchable, and linked content between differential diagnostic categories is perfectly suited for residents, while new images and outstanding graphics make this text ideal for both residents and practitioners
- Time-saving reference features include bulleted text, a variety of data tables, key facts in each chapter, annotated images, and an extensive index
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Diagnostic Pathology: Breast | iii | ||
| Copyright Page | iv | ||
| Table of Contents | xii | ||
| Dedications | v | ||
| Preface | vi | ||
| Acknowledgments | ix | ||
| Sections | xi | ||
| SECTION 1: Normal Breast | 3 | ||
| Chapter 1. Histology of Normal Breast | 4 | ||
| TERMINOLOGY | 4 | ||
| INTRODUCTION | 4 | ||
| GROSS ANATOMY | 4 | ||
| MICROSCOPIC ANATOMY | 4 | ||
| EPITHELIAL CELLS | 5 | ||
| MAMMARY STROMA | 6 | ||
| SELECTED REFERENCES | 7 | ||
| Chapter 2.\rBreast Life Cycle Changes | 14 | ||
| FEMALE BREAST | 14 | ||
| SELECTED REFERENCES | 16 | ||
| SECTION 2:\rBreast Specimens, Processing | 21 | ||
| Chapter 3.\rGeneral Considerations | 22 | ||
| COMMUNICATION BETWEEN SURGEONS AND PATHOLOGISTS | 22 | ||
| INTRAOPERATIVE CONSULTATIONS | 22 | ||
| SPECIMEN RADIOGRAPHY | 23 | ||
| FIXATION | 24 | ||
| TISSUE FOR SPECIAL STUDIES | 25 | ||
| ERRORS IN SPECIMEN PROCESSING | 25 | ||
| REPORTING | 26 | ||
| SELECTED REFERENCES | 26 | ||
| Chapter 4.\rCore Needle Biopsies | 30 | ||
| FEATURES OF HIGH-QUALITY CORE NEEDLE BIOPSY PROGRAM | 30 | ||
| MODALITIES | 30 | ||
| TYPES OF NEEDLE BIOPSIES | 31 | ||
| SPECIMEN PROCESSING | 31 | ||
| CHALLENGES IN NEEDLE BIOPSY SPECIMENS | 32 | ||
| REPORTING CORE BIOPSY RESULTS | 33 | ||
| CHALLENGES IN EXCISIONS | 33 | ||
| SELECTED REFERENCES | 34 | ||
| Chapter 5.\rExcisions | 42 | ||
| INTRODUCTION | 42 | ||
| SPECIMEN PROCESSING | 43 | ||
| DIFFICULT CASES | 45 | ||
| SELECTED REFERENCES | 45 | ||
| Chapter 6.\rMargins and Reexcisions | 48 | ||
| INTRODUCTION | 48 | ||
| TYPES OF MARGINS | 49 | ||
| RADIOLOGIC EVALUATION OF MARGINS | 50 | ||
| IMMEDIATE GROSS ASSESSMENT OF MARGINS | 50 | ||
| SAMPLING MARGINS | 50 | ||
| ORIENTATION OF MARGINS | 50 | ||
| REPORTING MARGINS | 51 | ||
| SELECTED REFERENCES | 51 | ||
| Chapter 7.\rMastectomies | 54 | ||
| INTRODUCTION | 54 | ||
| SPECIMEN PROCESSING | 55 | ||
| SELECTED REFERENCES | 56 | ||
| Chapter 8.\rReduction Mammoplasties | 60 | ||
| TERMINOLOGY | 60 | ||
| INTRODUCTION | 60 | ||
| MACROSCOPIC | 61 | ||
| SELECTED REFERENCES | 61 | ||
| SECTION 3: Diagnostic Patterns | 65 | ||
| Chapter 9.\rOverview of Papillary Lesions | 66 | ||
| TERMINOLOGY | 66 | ||
| ETIOLOGY/PATHOGENESIS | 66 | ||
| CLINICAL IMPLICATIONS | 66 | ||
| MICROSCOPIC | 67 | ||
| SELECTED REFERENCES | 68 | ||
| Chapter 10.\rOverview of Spindle Cell Lesions | 70 | ||
| SECTION 4:\rDisorders of Development | 77 | ||
| Chapter 11.\rJuvenile Papillomatosis | 78 | ||
| TERMINOLOGY | 79 | ||
| ETIOLOGY/PATHOGENESIS | 79 | ||
| CLINICAL ISSUES | 79 | ||
| IMAGING | 79 | ||
| MACROSCOPIC | 79 | ||
| MICROSCOPIC | 79 | ||
| DIFFERENTIAL DIAGNOSIS | 79 | ||
| SELECTED REFERENCES | 79 | ||
| Chapter 12.\rGynecomastia | 80 | ||
| TERMINOLOGY | 81 | ||
| ETIOLOGY/PATHOGENESIS | 81 | ||
| CLINICAL ISSUES | 81 | ||
| IMAGING | 81 | ||
| MACROSCOPIC | 82 | ||
| MICROSCOPIC | 82 | ||
| ANCILLARY TESTS | 82 | ||
| DIFFERENTIAL DIAGNOSIS | 82 | ||
| SELECTED REFERENCES | 82 | ||
| Chapter 13.\rHamartoma (Fibroadenolipoma) | 84 | ||
| TERMINOLOGY | 85 | ||
| ETIOLOGY/PATHOGENESIS | 85 | ||
| CLINICAL ISSUES | 85 | ||
| IMAGING | 85 | ||
| MACROSCOPIC | 85 | ||
| MICROSCOPIC | 85 | ||
| ANCILLARY TESTS | 86 | ||
| DIFFERENTIAL DIAGNOSIS | 86 | ||
| DIAGNOSTIC CHECKLIST | 86 | ||
| REPORTING | 86 | ||
| SELECTED REFERENCES | 86 | ||
| SECTION 5:\rBenign Epithelial Lesions | 89 | ||
| Chapter 14.\rEpidemiology: Lesions Conferring Increased Risk of Breast Carcinoma | 90 | ||
| TERMINOLOGY | 90 | ||
| INTRODUCTION | 90 | ||
| EPIDEMIOLOGY | 91 | ||
| CLINICAL IMPLICATIONS | 92 | ||
| MICROSCOPIC | 92 | ||
| SELECTED REFERENCES | 93 | ||
| Chapter 15.\rNonproliferative Changes | 96 | ||
| TERMINOLOGY | 97 | ||
| ETIOLOGY/PATHOGENESIS | 97 | ||
| CLINICAL ISSUES | 97 | ||
| IMAGING | 97 | ||
| MACROSCOPIC | 97 | ||
| MICROSCOPIC | 97 | ||
| DIFFERENTIAL DIAGNOSIS | 98 | ||
| SELECTED REFERENCES | 98 | ||
| Chapter 16. Columnar Cell Change, Columnar Cell Hyperplasia, and Flat Epithelial Atypia | 100 | ||
| TERMINOLOGY | 101 | ||
| ETIOLOGY/PATHOGENESIS | 101 | ||
| CLINICAL ISSUES | 101 | ||
| IMAGING | 102 | ||
| MACROSCOPIC | 102 | ||
| MICROSCOPIC | 102 | ||
| ANCILLARY TESTS | 102 | ||
| DIFFERENTIAL DIAGNOSIS | 102 | ||
| DIAGNOSTIC CHECKLIST | 103 | ||
| REPORTING | 103 | ||
| SELECTED REFERENCES | 103 | ||
| Chapter 17.\rMucocele-Like Lesions | 108 | ||
| TERMINOLOGY | 109 | ||
| ETIOLOGY/PATHOGENESIS | 109 | ||
| CLINICAL ISSUES | 109 | ||
| IMAGING | 109 | ||
| MICROSCOPIC | 109 | ||
| ANCILLARY TESTS | 110 | ||
| DIFFERENTIAL DIAGNOSIS | 110 | ||
| DIAGNOSTIC CHECKLIST | 110 | ||
| SELECTED REFERENCES | 110 | ||
| Chapter 18.\rCollagenous Spherulosis | 112 | ||
| TERMINOLOGY | 113 | ||
| CLINICAL ISSUES | 113 | ||
| MICROSCOPIC | 113 | ||
| DIFFERENTIAL DIAGNOSIS | 113 | ||
| DIAGNOSTIC CHECKLIST | 113 | ||
| SELECTED REFERENCES | 113 | ||
| Chapter 19.\rGynecomastoid Hyperplasia | 118 | ||
| TERMINOLOGY | 119 | ||
| ETIOLOGY/PATHOGENESIS | 119 | ||
| CLINICAL ISSUES | 119 | ||
| IMAGING | 119 | ||
| MACROSCOPIC | 119 | ||
| MICROSCOPIC | 119 | ||
| DIFFERENTIAL DIAGNOSIS | 119 | ||
| SELECTED REFERENCES | 119 | ||
| Chapter 20.\rSyringomatous Tumor of the Nipple | 120 | ||
| TERMINOLOGY | 121 | ||
| ETIOLOGY/PATHOGENESIS | 121 | ||
| CLINICAL ISSUES | 121 | ||
| IMAGING | 121 | ||
| MACROSCOPIC | 121 | ||
| MICROSCOPIC | 121 | ||
| ANCILLARY TESTS | 122 | ||
| DIFFERENTIAL DIAGNOSIS | 122 | ||
| DIAGNOSTIC CHECKLIST | 122 | ||
| SELECTED REFERENCES | 122 | ||
| Chapter 21.\rSclerosing Adenosis | 126 | ||
| TERMINOLOGY | 127 | ||
| ETIOLOGY/PATHOGENESIS | 127 | ||
| CLINICAL ISSUES | 127 | ||
| IMAGING | 127 | ||
| MACROSCOPIC | 127 | ||
| MICROSCOPIC | 127 | ||
| ANCILLARY TESTS | 128 | ||
| DIFFERENTIAL DIAGNOSIS | 128 | ||
| DIAGNOSTIC CHECKLIST | 129 | ||
| REPORTING | 129 | ||
| SELECTED REFERENCES | 129 | ||
| Chapter 22.\rEpithelial Hyperplasia | 134 | ||
| TERMINOLOGY | 135 | ||
| ETIOLOGY/PATHOGENESIS | 135 | ||
| CLINICAL ISSUES | 135 | ||
| IMAGING | 135 | ||
| MACROSCOPIC | 135 | ||
| MICROSCOPIC | 135 | ||
| ANCILLARY TESTS | 136 | ||
| DIFFERENTIAL DIAGNOSIS | 136 | ||
| DIAGNOSTIC CHECKLIST | 137 | ||
| REPORTING | 137 | ||
| SELECTED REFERENCES | 137 | ||
| Chapter 23. Radial Sclerosing Lesion/Radial Scar | 140 | ||
| TERMINOLOGY | 141 | ||
| ETIOLOGY/PATHOGENESIS | 141 | ||
| CLINICAL ISSUES | 141 | ||
| IMAGING | 141 | ||
| MACROSCOPIC | 142 | ||
| MICROSCOPIC | 142 | ||
| ANCILLARY TESTS | 142 | ||
| DIFFERENTIAL DIAGNOSIS | 142 | ||
| DIAGNOSTIC CHECKLIST | 143 | ||
| SELECTED REFERENCES | 143 | ||
| Chapter 24.\rPapilloma, Large Duct and Small Duct | 146 | ||
| TERMINOLOGY | 147 | ||
| ETIOLOGY/PATHOGENESIS | 147 | ||
| CLINICAL ISSUES | 147 | ||
| IMAGING | 147 | ||
| MACROSCOPIC | 148 | ||
| MICROSCOPIC | 148 | ||
| ANCILLARY TESTS | 149 | ||
| DIFFERENTIAL DIAGNOSIS | 149 | ||
| DIAGNOSTIC CHECKLIST | 149 | ||
| REPORTING | 150 | ||
| SELECTED REFERENCES | 150 | ||
| Chapter 25.\rNipple Adenoma | 156 | ||
| TERMINOLOGY | 157 | ||
| CLINICAL ISSUES | 157 | ||
| IMAGING | 157 | ||
| MACROSCOPIC | 157 | ||
| MICROSCOPIC | 157 | ||
| DIFFERENTIAL DIAGNOSIS | 158 | ||
| DIAGNOSTIC CHECKLIST | 158 | ||
| SELECTED REFERENCES | 158 | ||
| Chapter 26.\rMicroglandular Adenosis | 162 | ||
| TERMINOLOGY | 163 | ||
| CLASSIFICATION | 163 | ||
| ETIOLOGY/PATHOGENESIS | 163 | ||
| CLINICAL ISSUES | 163 | ||
| IMAGING | 164 | ||
| MACROSCOPIC | 164 | ||
| MICROSCOPIC | 164 | ||
| ANCILLARY TESTS | 164 | ||
| DIFFERENTIAL DIAGNOSIS | 164 | ||
| DIAGNOSTIC CHECKLIST | 165 | ||
| REPORTING | 165 | ||
| SELECTED REFERENCES | 165 | ||
| Chapter 27.\rAtypical Ductal Hyperplasia | 168 | ||
| TERMINOLOGY | 169 | ||
| ETIOLOGY/PATHOGENESIS | 169 | ||
| CLINICAL ISSUES | 169 | ||
| IMAGING | 170 | ||
| MACROSCOPIC | 170 | ||
| MICROSCOPIC | 170 | ||
| ANCILLARY TESTS | 171 | ||
| DIFFERENTIAL DIAGNOSIS | 171 | ||
| DIAGNOSTIC CHECKLIST | 171 | ||
| REPORTING | 172 | ||
| SELECTED REFERENCES | 172 | ||
| Chapter 28.\rAtypical Lobular Hyperplasia | 176 | ||
| TERMINOLOGY | 177 | ||
| ETIOLOGY/PATHOGENESIS | 177 | ||
| CLINICAL ISSUES | 177 | ||
| IMAGING | 178 | ||
| MICROSCOPIC | 178 | ||
| ANCILLARY TESTS | 178 | ||
| DIFFERENTIAL DIAGNOSIS | 179 | ||
| DIAGNOSTIC CHECKLIST | 179 | ||
| REPORTING | 179 | ||
| SELECTED REFERENCES | 179 | ||
| SECTION 6: Carcinomas | 182 | ||
| Chapter 29.\rRisk Factors for Developing Breast Carcinoma | 184 | ||
| BREAST CANCER RISK | 184 | ||
| FACTORS ASSOCIATED WITH BREAST CANCER RISK | 184 | ||
| CLINICAL IMPLICATIONS | 187 | ||
| SELECTED REFERENCES | 187 | ||
| Carcinoma In Situ | 190 | ||
| Chapter 30.\rLobular Carcinoma In Situ | 190 | ||
| TERMINOLOGY | 191 | ||
| ETIOLOGY/PATHOGENESIS | 191 | ||
| CLINICAL ISSUES | 191 | ||
| IMAGING | 192 | ||
| MACROSCOPIC | 192 | ||
| MICROSCOPIC | 192 | ||
| ANCILLARY TESTS | 193 | ||
| DIFFERENTIAL DIAGNOSIS | 193 | ||
| DIAGNOSTIC CHECKLIST | 194 | ||
| REPORTING | 194 | ||
| SELECTED REFERENCES | 194 | ||
| Chapter 31.\rDuctal Carcinoma In Situ | 202 | ||
| TERMINOLOGY | 203 | ||
| ETIOLOGY/PATHOGENESIS | 203 | ||
| CLINICAL ISSUES | 203 | ||
| IMAGING | 204 | ||
| MACROSCOPIC | 204 | ||
| MICROSCOPIC | 204 | ||
| ANCILLARY TESTS | 205 | ||
| DIFFERENTIAL DIAGNOSIS | 205 | ||
| DIAGNOSTIC CHECKLIST | 206 | ||
| REPORTING | 206 | ||
| SELECTED REFERENCES | 206 | ||
| Chapter 32.\rDuctal Carcinoma In Situ, Paget Disease | 216 | ||
| TERMINOLOGY | 217 | ||
| ETIOLOGY/PATHOGENESIS | 217 | ||
| CLINICAL ISSUES | 217 | ||
| IMAGING | 218 | ||
| MACROSCOPIC | 218 | ||
| MICROSCOPIC | 218 | ||
| ANCILLARY TESTS | 219 | ||
| DIFFERENTIAL DIAGNOSIS | 219 | ||
| DIAGNOSTIC CHECKLIST | 220 | ||
| REPORTING | 220 | ||
| SELECTED REFERENCES | 220 | ||
| Chapter 33.\rDuctal Carcinoma In Situ With Microinvasion | 226 | ||
| TERMINOLOGY | 227 | ||
| ETIOLOGY/PATHOGENESIS | 227 | ||
| CLINICAL ISSUES | 227 | ||
| IMAGING | 227 | ||
| MACROSCOPIC | 227 | ||
| MICROSCOPIC | 228 | ||
| ANCILLARY TESTS | 229 | ||
| DIFFERENTIAL DIAGNOSIS | 229 | ||
| DIAGNOSTIC CHECKLIST | 229 | ||
| REPORTING | 229 | ||
| SELECTED REFERENCES | 229 | ||
| Chapter 34.\rEncapsulated Papillary Carcinoma | 232 | ||
| TERMINOLOGY | 233 | ||
| ETIOLOGY/PATHOGENESIS | 233 | ||
| CLINICAL ISSUES | 233 | ||
| IMAGING | 233 | ||
| MACROSCOPIC | 233 | ||
| MOLECULAR | 233 | ||
| MICROSCOPIC | 233 | ||
| ANCILLARY TESTS | 234 | ||
| DIFFERENTIAL DIAGNOSIS | 234 | ||
| DIAGNOSTIC CHECKLIST | 234 | ||
| REPORTING | 235 | ||
| SELECTED REFERENCES | 235 | ||
| Types of Invasive Carcinoma | 238 | ||
| Chapter 35.\rInvasive Ductal Carcinoma (Adenocarcinomas of No Special Type) | 238 | ||
| TERMINOLOGY | 239 | ||
| CLASSIFICATION | 239 | ||
| CLINICAL ISSUES | 239 | ||
| IMAGING | 240 | ||
| MACROSCOPIC | 240 | ||
| MICROSCOPIC | 240 | ||
| ANCILLARY TESTS | 241 | ||
| DIFFERENTIAL DIAGNOSIS | 241 | ||
| SELECTED REFERENCES | 242 | ||
| Chapter 36.\rInvasive Lobular Carcinoma | 248 | ||
| TERMINOLOGY | 249 | ||
| CLASSIFICATION | 249 | ||
| ETIOLOGY/PATHOGENESIS | 249 | ||
| CLINICAL ISSUES | 250 | ||
| IMAGING | 250 | ||
| MACROSCOPIC | 250 | ||
| MICROSCOPIC | 250 | ||
| ANCILLARY TESTS | 251 | ||
| DIFFERENTIAL DIAGNOSIS | 252 | ||
| DIAGNOSTIC CHECKLIST | 252 | ||
| GRADING | 252 | ||
| REPORTING | 252 | ||
| SELECTED REFERENCES | 252 | ||
| Chapter 37.\rInvasive Lobular Carcinoma Variants | 258 | ||
| TERMINOLOGY | 259 | ||
| CLASSIFICATION | 259 | ||
| ETIOLOGY/PATHOGENESIS | 259 | ||
| CLINICAL ISSUES | 259 | ||
| IMAGING | 260 | ||
| MICROSCOPIC | 260 | ||
| ANCILLARY TESTS | 260 | ||
| DIFFERENTIAL DIAGNOSIS | 260 | ||
| DIAGNOSTIC CHECKLIST | 261 | ||
| REPORTING | 261 | ||
| SELECTED REFERENCES | 261 | ||
| Chapter 38.\rTubular/Cribriform Carcinoma | 264 | ||
| TERMINOLOGY | 265 | ||
| ETIOLOGY/PATHOGENESIS | 265 | ||
| CLINICAL ISSUES | 265 | ||
| IMAGING | 265 | ||
| MACROSCOPIC | 265 | ||
| MICROSCOPIC | 266 | ||
| ANCILLARY TESTS | 266 | ||
| DIFFERENTIAL DIAGNOSIS | 266 | ||
| DIAGNOSTIC CHECKLIST | 267 | ||
| GRADING | 267 | ||
| REPORTING | 267 | ||
| SELECTED REFERENCES | 267 | ||
| Chapter 39.\rTubulolobular Carcinoma | 272 | ||
| TERMINOLOGY | 273 | ||
| ETIOLOGY/PATHOGENESIS | 273 | ||
| CLINICAL ISSUES | 273 | ||
| IMAGING | 273 | ||
| MACROSCOPIC | 273 | ||
| MICROSCOPIC | 273 | ||
| ANCILLARY TESTS | 274 | ||
| DIFFERENTIAL DIAGNOSIS | 274 | ||
| DIAGNOSTIC CHECKLIST | 274 | ||
| REPORTING | 274 | ||
| SELECTED REFERENCES | 274 | ||
| Chapter 40.\rCarcinoma With Medullary Features | 276 | ||
| TERMINOLOGY | 277 | ||
| CLASSIFICATION | 277 | ||
| ETIOLOGY/PATHOGENESIS | 277 | ||
| CLINICAL ISSUES | 277 | ||
| IMAGING | 278 | ||
| MACROSCOPIC | 278 | ||
| MICROSCOPIC | 278 | ||
| ANCILLARY TESTS | 279 | ||
| DIFFERENTIAL DIAGNOSIS | 279 | ||
| DIAGNOSTIC CHECKLIST | 279 | ||
| REPORTING | 279 | ||
| SELECTED REFERENCES | 279 | ||
| Chapter 41.\rMucinous (Colloid) Carcinoma | 282 | ||
| TERMINOLOGY | 283 | ||
| ETIOLOGY/PATHOGENESIS | 283 | ||
| CLINICAL ISSUES | 283 | ||
| IMAGING | 283 | ||
| MACROSCOPIC | 284 | ||
| MICROSCOPIC | 284 | ||
| ANCILLARY TESTS | 285 | ||
| DIFFERENTIAL DIAGNOSIS | 285 | ||
| DIAGNOSTIC CHECKLIST | 286 | ||
| SELECTED REFERENCES | 286 | ||
| Chapter 42.\rInvasive Papillary Carcinoma | 292 | ||
| TERMINOLOGY | 293 | ||
| ETIOLOGY/PATHOGENESIS | 293 | ||
| CLINICAL ISSUES | 293 | ||
| IMAGING | 293 | ||
| MACROSCOPIC | 293 | ||
| MICROSCOPIC | 293 | ||
| ANCILLARY TESTS | 294 | ||
| DIFFERENTIAL DIAGNOSIS | 294 | ||
| DIAGNOSTIC CHECKLIST | 294 | ||
| REPORTING | 294 | ||
| SELECTED REFERENCES | 294 | ||
| Chapter 43.\rInvasive Micropapillary Carcinoma | 298 | ||
| TERMINOLOGY | 299 | ||
| ETIOLOGY/PATHOGENESIS | 299 | ||
| CLINICAL ISSUES | 299 | ||
| IMAGING | 299 | ||
| MACROSCOPIC | 299 | ||
| MOLECULAR | 299 | ||
| MICROSCOPIC | 300 | ||
| ANCILLARY TESTS | 300 | ||
| DIFFERENTIAL DIAGNOSIS | 301 | ||
| DIAGNOSTIC CHECKLIST | 301 | ||
| REPORTING | 301 | ||
| SELECTED REFERENCES | 301 | ||
| Chapter 44.\rMetaplastic Carcinoma | 306 | ||
| TERMINOLOGY | 307 | ||
| ETIOLOGY/PATHOGENESIS | 307 | ||
| CLINICAL ISSUES | 307 | ||
| IMAGING | 308 | ||
| MACROSCOPIC | 308 | ||
| MICROSCOPIC | 308 | ||
| ANCILLARY TESTS | 309 | ||
| DIFFERENTIAL DIAGNOSIS | 309 | ||
| DIAGNOSTIC CHECKLIST | 310 | ||
| REPORTING | 310 | ||
| SELECTED REFERENCES | 310 | ||
| Chapter 45.\rLow-Grade Adenosquamous Carcinoma | 316 | ||
| TERMINOLOGY | 317 | ||
| ETIOLOGY/PATHOGENESIS | 317 | ||
| CLINICAL ISSUES | 317 | ||
| IMAGING | 317 | ||
| MACROSCOPIC | 317 | ||
| MICROSCOPIC | 317 | ||
| ANCILLARY TESTS | 318 | ||
| DIFFERENTIAL DIAGNOSIS | 318 | ||
| SELECTED REFERENCES | 318 | ||
| Chapter 46.\rBasal-Like Carcinoma | 324 | ||
| TERMINOLOGY | 325 | ||
| ETIOLOGY/PATHOGENESIS | 325 | ||
| CLINICAL ISSUES | 326 | ||
| IMAGING | 326 | ||
| MACROSCOPIC | 326 | ||
| MICROSCOPIC | 326 | ||
| ANCILLARY TESTS | 327 | ||
| DIFFERENTIAL DIAGNOSIS | 327 | ||
| DIAGNOSTIC CHECKLIST | 328 | ||
| REPORTING | 328 | ||
| SELECTED REFERENCES | 328 | ||
| Chapter 47.\rAdenoid Cystic Carcinoma | 332 | ||
| TERMINOLOGY | 333 | ||
| ETIOLOGY/PATHOGENESIS | 333 | ||
| CLINICAL ISSUES | 333 | ||
| IMAGING | 334 | ||
| MACROSCOPIC | 334 | ||
| MOLECULAR | 334 | ||
| MICROSCOPIC | 334 | ||
| ANCILLARY TESTS | 334 | ||
| DIFFERENTIAL DIAGNOSIS | 335 | ||
| DIAGNOSTIC CHECKLIST | 336 | ||
| REPORTING | 336 | ||
| SELECTED REFERENCES | 336 | ||
| Chapter 48.\rSecretory Carcinoma | 342 | ||
| TERMINOLOGY | 343 | ||
| ETIOLOGY/PATHOGENESIS | 343 | ||
| CLINICAL ISSUES | 343 | ||
| IMAGING | 344 | ||
| MACROSCOPIC | 344 | ||
| MICROSCOPIC | 344 | ||
| ANCILLARY TESTS | 344 | ||
| DIFFERENTIAL DIAGNOSIS | 344 | ||
| DIAGNOSTIC CHECKLIST | 345 | ||
| REPORTING | 345 | ||
| SELECTED REFERENCES | 345 | ||
| Chapter 49.\rHER2-Positive Carcinoma | 350 | ||
| TERMINOLOGY | 351 | ||
| ETIOLOGY/PATHOGENESIS | 351 | ||
| CLINICAL ISSUES | 351 | ||
| MICROSCOPIC | 352 | ||
| ANCILLARY TESTS | 353 | ||
| DIFFERENTIAL DIAGNOSIS | 354 | ||
| DIAGNOSTIC CHECKLIST | 354 | ||
| REPORTING | 354 | ||
| SELECTED REFERENCES | 354 | ||
| Chapter 50.\rInflammatory Carcinoma | 360 | ||
| TERMINOLOGY | 361 | ||
| ETIOLOGY/PATHOGENESIS | 361 | ||
| CLINICAL ISSUES | 361 | ||
| IMAGING | 362 | ||
| MACROSCOPIC | 362 | ||
| MICROSCOPIC | 362 | ||
| ANCILLARY TESTS | 363 | ||
| DIFFERENTIAL DIAGNOSIS | 363 | ||
| STAGING | 363 | ||
| REPORTING | 363 | ||
| SELECTED REFERENCES | 363 | ||
| Chapter 51.\rInvasive Apocrine Carcinoma | 366 | ||
| TERMINOLOGY | 367 | ||
| ETIOLOGY/PATHOGENESIS | 367 | ||
| CLINICAL ISSUES | 367 | ||
| IMAGING | 368 | ||
| MICROSCOPIC | 368 | ||
| ANCILLARY TESTS | 368 | ||
| DIFFERENTIAL DIAGNOSIS | 368 | ||
| DIAGNOSTIC CHECKLIST | 369 | ||
| REPORTING | 369 | ||
| SELECTED REFERENCES | 369 | ||
| Chapter 52.\rCarcinoma With Neuroendocrine Features | 372 | ||
| TERMINOLOGY | 373 | ||
| ETIOLOGY/PATHOGENESIS | 373 | ||
| CLINICAL ISSUES | 373 | ||
| MICROSCOPIC | 374 | ||
| ANCILLARY TESTS | 374 | ||
| DIFFERENTIAL DIAGNOSIS | 375 | ||
| DIAGNOSTIC CHECKLIST | 375 | ||
| SELECTED REFERENCES | 375 | ||
| Chapter 53.\rInvasive Carcinoma With Osteoclast-Like Giant Cells | 380 | ||
| TERMINOLOGY | 381 | ||
| ETIOLOGY/PATHOGENESIS | 381 | ||
| CLINICAL ISSUES | 381 | ||
| IMAGING | 381 | ||
| MACROSCOPIC | 381 | ||
| MICROSCOPIC | 381 | ||
| DIFFERENTIAL DIAGNOSIS | 381 | ||
| SELECTED REFERENCES | 381 | ||
| Chapter 54. Carcinoma With Extensive Intraductal Component | 382 | ||
| TERMINOLOGY | 382 | ||
| EPIDEMIOLOGY | 382 | ||
| CLINICAL IMPLICATIONS | 382 | ||
| IMAGING CORRELATIONS | 383 | ||
| ANATOMIC DISTRIBUTION OF DCIS | 384 | ||
| BIOLOGIC CORRELATIONS FOR EIC | 384 | ||
| SELECTED REFERENCES | 384 | ||
| Prognostic and Predictive Factors | 386 | ||
| Chapter 55. Introduction: Prognostic and Predictive Factors | 386 | ||
| TERMINOLOGY | 386 | ||
| GENERAL CONSIDERATIONS | 386 | ||
| MAJOR PROGNOSTIC FACTORS | 386 | ||
| ADDITIONAL PROGNOSTIC FACTORS | 388 | ||
| COMBINING PROGNOSTIC FACTORS | 389 | ||
| SELECTED REFERENCES | 390 | ||
| Chapter 56. Size and Multiple Foci | 394 | ||
| INTRODUCTION | 394 | ||
| METHODS OF EVALUATION | 395 | ||
| DIFFICULT SPECIMENS | 396 | ||
| REPORTING CRITERIA | 396 | ||
| SELECTED REFERENCES | 396 | ||
| Chapter 57. AJCC T4 Carcinomas (Chest Wall or Skin Involvement) | 398 | ||
| TERMINOLOGY | 398 | ||
| ETIOLOGY/PATHOGENESIS | 398 | ||
| EPIDEMIOLOGY | 399 | ||
| CLINICAL IMPLICATIONS | 399 | ||
| MACROSCOPIC | 399 | ||
| MICROSCOPIC | 400 | ||
| DIFFERENTIAL DIAGNOSIS | 400 | ||
| SELECTED REFERENCES | 400 | ||
| Chapter 58. Lymph Node Metastases | 404 | ||
| CLINICAL IMPLICATIONS | 404 | ||
| MACROSCOPIC | 405 | ||
| MICROSCOPIC | 406 | ||
| REPORTING CRITERIA | 406 | ||
| ANCILLARY STUDIES | 406 | ||
| DIFFERENTIAL DIAGNOSIS | 407 | ||
| SELECTED REFERENCES | 408 | ||
| Chapter 59. Histologic Grade | 416 | ||
| TERMINOLOGY | 416 | ||
| GENERAL CONSIDERATIONS | 416 | ||
| SPECIAL HISTOLOGIC TYPES AND GRADE | 417 | ||
| CLINICAL/PATHOLOGIC CORRELATES AND GRADE | 418 | ||
| GRADE AND GENOMIC CHANGES | 419 | ||
| SELECTED REFERENCES | 419 | ||
| Chapter 60. Lymph-Vascular Invasion | 422 | ||
| TERMINOLOGY | 422 | ||
| EPIDEMIOLOGY | 422 | ||
| CLINICAL IMPLICATIONS | 422 | ||
| MICROSCOPIC | 423 | ||
| DIFFERENTIAL DIAGNOSIS | 424 | ||
| SELECTED REFERENCES | 424 | ||
| Chapter 61. Hormone Receptors (ER/PR) | 430 | ||
| TERMINOLOGY | 430 | ||
| BREAST HORMONE RECEPTORS | 430 | ||
| HORMONE RECEPTORS AND BREASTCANCER | 431 | ||
| CLINICAL IMPLICATIONS | 431 | ||
| IMPLICATIONS FOR TESTING | 432 | ||
| QUALITY ASSESSMENT AND QUALITY CONTROL | 433 | ||
| HORMONE RECEPTOR TESTING BY MRNA | 434 | ||
| SELECTED REFERENCES | 434 | ||
| Chapter 62. HER2 | 440 | ||
| TERMINOLOGY | 440 | ||
| ETIOLOGY/PATHOGENESIS | 440 | ||
| CLINICAL IMPLICATIONS | 440 | ||
| CORE NEEDLE BIOPSIES | 444 | ||
| SELECTED REFERENCES | 444 | ||
| Chapter 63. Locally Recurrent Carcinoma | 452 | ||
| TERMINOLOGY | 453 | ||
| ETIOLOGY/PATHOGENESIS | 453 | ||
| CLINICAL ISSUES | 453 | ||
| ANCILLARY TESTS | 454 | ||
| DIFFERENTIAL DIAGNOSIS | 455 | ||
| DIAGNOSTIC CHECKLIST | 455 | ||
| REPORTING | 455 | ||
| SELECTED REFERENCES | 455 | ||
| Chapter 64. Neoadjuvant Therapy | 458 | ||
| TERMINOLOGY | 458 | ||
| CLINICAL IMPLICATIONS | 458 | ||
| MACROSCOPIC | 459 | ||
| MICROSCOPIC | 460 | ||
| REPORTING AFTER NEOADJUVANT THERAPY | 461 | ||
| SELECTED REFERENCES | 462 | ||
| Chapter 65. Circulating Tumor Cells | 468 | ||
| TERMINOLOGY | 468 | ||
| CLINICAL ISSUES | 468 | ||
| SELECTED REFERENCES | 469 | ||
| New Approaches to Breast Cancer\rEvaluation Using Multigene Assays | 470 | ||
| Chapter 66. DNA Analysis | 470 | ||
| TERMINOLOGY | 470 | ||
| DNA ALTERATIONS IN BREAST CANCER | 470 | ||
| ETIOLOGY/PATHOGENESIS | 470 | ||
| CLINICAL IMPLICATIONS | 471 | ||
| SELECTED REFERENCES | 471 | ||
| Chapter 67. Expression Profiling, mRNA | 474 | ||
| TERMINOLOGY | 474 | ||
| GENE EXPRESSION PROFILING | 474 | ||
| CLINICAL IMPLICATIONS | 474 | ||
| EXPRESSION PROFILING ASSAYS | 475 | ||
| SELECTED REFERENCES | 476 | ||
| Chapter 68. Expression Profiling, Oncotype DX Assay | 478 | ||
| INTRODUCTION | 478 | ||
| ONCOTYPE DX FOR INVASIVE CARCINOMA | 478 | ||
| PREDICTION OF ONCOTYPE DX RS | 479 | ||
| ONCOTYPE DX SINGLE GENE SCORES | 480 | ||
| ONCOTYPE DX FOR DCIS | 480 | ||
| SELECTED REFERENCES | 481 | ||
| Chapter 69. Expression Profiling, MammaPrint Assay | 482 | ||
| TERMINOLOGY | 482 | ||
| INTRODUCTION | 482 | ||
| MAMMAPRINT | 482 | ||
| SELECTED REFERENCES | 483 | ||
| Chapter 70. Expression Profiling, Prosigna (NanoString)/PAM50 | 484 | ||
| INTRODUCTION | 484 | ||
| PAM50 ASSAY | 484 | ||
| SELECTED REFERENCES | 485 | ||
| Chapter 71. Expression Profiling, Protein | 486 | ||
| TERMINOLOGY | 486 | ||
| INTRODUCTION | 486 | ||
| PROTEIN EXPRESSION PROFILING | 487 | ||
| PROTEIN EXPRESSION PROFILING: SINGLE ANTIBODIES | 487 | ||
| PROTEIN EXPRESSION PROFILING: MULTIPLE ANTIBODY PANELS | 487 | ||
| SPECIAL TECHNIQUES FOR PROTEIN EVALUATION | 489 | ||
| SELECTED REFERENCES | 489 | ||
| SECTION 7: Stromal Lesions | 495 | ||
| Chapter 72.\rFibroadenoma | 496 | ||
| TERMINOLOGY | 497 | ||
| ETIOLOGY/PATHOGENESIS | 497 | ||
| CLINICAL ISSUES | 497 | ||
| IMAGING | 497 | ||
| MACROSCOPIC | 498 | ||
| MICROSCOPIC | 498 | ||
| ANCILLARY TESTS | 499 | ||
| DIFFERENTIAL DIAGNOSIS | 499 | ||
| SELECTED REFERENCES | 499 | ||
| Chapter 73. Phyllodes Tumor | 504 | ||
| TERMINOLOGY | 505 | ||
| ETIOLOGY/PATHOGENESIS | 505 | ||
| CLINICAL ISSUES | 505 | ||
| IMAGING | 506 | ||
| MACROSCOPIC | 506 | ||
| MICROSCOPIC | 506 | ||
| ANCILLARY TESTS | 507 | ||
| DIFFERENTIAL DIAGNOSIS | 507 | ||
| DIAGNOSTIC CHECKLIST | 508 | ||
| REPORTING | 508 | ||
| SELECTED REFERENCES | 508 | ||
| Chapter 74. Pseudoangiomatous Stromal Hyperplasia | 514 | ||
| TERMINOLOGY | 515 | ||
| ETIOLOGY/PATHOGENESIS | 515 | ||
| CLINICAL ISSUES | 515 | ||
| IMAGING | 515 | ||
| MACROSCOPIC | 515 | ||
| MICROSCOPIC | 515 | ||
| ANCILLARY TESTS | 515 | ||
| DIFFERENTIAL DIAGNOSIS | 515 | ||
| SELECTED REFERENCES | 515 | ||
| Chapter 75. Myofibroblastoma | 518 | ||
| TERMINOLOGY | 519 | ||
| ETIOLOGY/PATHOGENESIS | 519 | ||
| CLINICAL ISSUES | 519 | ||
| IMAGING | 519 | ||
| MACROSCOPIC | 520 | ||
| MICROSCOPIC | 520 | ||
| ANCILLARY TESTS | 520 | ||
| DIFFERENTIAL DIAGNOSIS | 521 | ||
| DIAGNOSTIC CHECKLIST | 522 | ||
| REPORTING | 522 | ||
| SELECTED REFERENCES | 522 | ||
| Chapter 76.\rLipoma and Angiolipoma | 526 | ||
| TERMINOLOGY | 527 | ||
| CLINICAL ISSUES | 527 | ||
| IMAGING | 527 | ||
| MACROSCOPIC | 527 | ||
| MICROSCOPIC | 527 | ||
| DIFFERENTIAL DIAGNOSIS | 527 | ||
| SELECTED REFERENCES | 527 | ||
| Chapter 77.\rDiabetic Mastopathy/Lymphocytic Mastopathy | 530 | ||
| TERMINOLOGY | 531 | ||
| ETIOLOGY/PATHOGENESIS | 531 | ||
| CLINICAL ISSUES | 531 | ||
| IMAGING | 531 | ||
| MACROSCOPIC | 531 | ||
| MICROSCOPIC | 531 | ||
| DIFFERENTIAL DIAGNOSIS | 531 | ||
| SELECTED REFERENCES | 531 | ||
| Chapter 78.\rGranular Cell Tumor | 534 | ||
| TERMINOLOGY | 535 | ||
| ETIOLOGY/PATHOGENESIS | 535 | ||
| CLINICAL ISSUES | 535 | ||
| IMAGING | 535 | ||
| MACROSCOPIC | 535 | ||
| MICROSCOPIC | 535 | ||
| ANCILLARY TESTS | 536 | ||
| DIFFERENTIAL DIAGNOSIS | 536 | ||
| DIAGNOSTIC CHECKLIST | 536 | ||
| SELECTED REFERENCES | 536 | ||
| Chapter 79.\rNodular Fasciitis | 540 | ||
| TERMINOLOGY | 541 | ||
| ETIOLOGY/PATHOGENESIS | 541 | ||
| CLINICAL ISSUES | 541 | ||
| IMAGING | 541 | ||
| MACROSCOPIC | 541 | ||
| MICROSCOPIC | 541 | ||
| ANCILLARY TESTS | 542 | ||
| DIFFERENTIAL DIAGNOSIS | 542 | ||
| DIAGNOSTIC CHECKLIST | 542 | ||
| SELECTED REFERENCES | 542 | ||
| Chapter 80.\rFibromatosis | 546 | ||
| TERMINOLOGY | 547 | ||
| ETIOLOGY/PATHOGENESIS | 547 | ||
| CLINICAL ISSUES | 547 | ||
| IMAGING | 547 | ||
| MACROSCOPIC | 547 | ||
| MICROSCOPIC | 547 | ||
| ANCILLARY TESTS | 548 | ||
| DIFFERENTIAL DIAGNOSIS | 548 | ||
| SELECTED REFERENCES | 548 | ||
| Chapter 81. Hemangiomas | 552 | ||
| TERMINOLOGY | 553 | ||
| ETIOLOGY/PATHOGENESIS | 553 | ||
| CLINICAL ISSUES | 553 | ||
| IMAGING | 553 | ||
| MACROSCOPIC | 553 | ||
| MICROSCOPIC | 553 | ||
| ANCILLARY TESTS | 554 | ||
| DIFFERENTIAL DIAGNOSIS | 554 | ||
| SELECTED REFERENCES | 554 | ||
| Chapter 82.\rPapillary Endothelial Hyperplasia | 558 | ||
| TERMINOLOGY | 559 | ||
| ETIOLOGY/PATHOGENESIS | 559 | ||
| CLINICAL ISSUES | 559 | ||
| IMAGING | 559 | ||
| MACROSCOPIC | 559 | ||
| MICROSCOPIC | 559 | ||
| DIFFERENTIAL DIAGNOSIS | 559 | ||
| SELECTED REFERENCES | 559 | ||
| Chapter 83.\rAtypical Vascular Lesions of Skin | 560 | ||
| TERMINOLOGY | 561 | ||
| ETIOLOGY/PATHOGENESIS | 561 | ||
| CLINICAL ISSUES | 561 | ||
| MACROSCOPIC | 561 | ||
| MICROSCOPIC | 561 | ||
| ANCILLARY TESTS | 561 | ||
| DIFFERENTIAL DIAGNOSIS | 562 | ||
| DIAGNOSTIC CHECKLIST | 562 | ||
| SELECTED REFERENCES | 562 | ||
| Chapter 84.\rAngiosarcoma | 564 | ||
| TERMINOLOGY | 565 | ||
| ETIOLOGY/PATHOGENESIS | 565 | ||
| CLINICAL ISSUES | 565 | ||
| IMAGING | 565 | ||
| MACROSCOPIC | 565 | ||
| MICROSCOPIC | 566 | ||
| ANCILLARY TESTS | 566 | ||
| DIFFERENTIAL DIAGNOSIS | 566 | ||
| DIAGNOSTIC CHECKLIST | 567 | ||
| SELECTED REFERENCES | 567 | ||
| Chapter 85.\rSarcomas | 572 | ||
| TERMINOLOGY | 573 | ||
| ETIOLOGY/PATHOGENESIS | 573 | ||
| CLINICAL ISSUES | 573 | ||
| IMAGING | 573 | ||
| MACROSCOPIC | 573 | ||
| MICROSCOPIC | 573 | ||
| ANCILLARY TESTS | 574 | ||
| DIFFERENTIAL DIAGNOSIS | 574 | ||
| DIAGNOSTIC CHECKLIST | 575 | ||
| SELECTED REFERENCES | 575 | ||
| SECTION 8: Inflammatory Lesions | 579 | ||
| Chapter 86.\rLactational Abscess | 580 | ||
| TERMINOLOGY | 581 | ||
| ETIOLOGY/PATHOGENESIS | 581 | ||
| CLINICAL ISSUES | 581 | ||
| MICROSCOPIC | 581 | ||
| DIFFERENTIAL DIAGNOSIS | 581 | ||
| SELECTED REFERENCES | 581 | ||
| Chapter 87. Fat Necrosis | 584 | ||
| TERMINOLOGY | 585 | ||
| ETIOLOGY/PATHOGENESIS | 585 | ||
| CLINICAL ISSUES | 585 | ||
| IMAGING | 585 | ||
| MACROSCOPIC | 586 | ||
| MICROSCOPIC | 586 | ||
| DIFFERENTIAL DIAGNOSIS | 586 | ||
| SELECTED REFERENCES | 586 | ||
| Chapter 88. Duct Ectasia | 588 | ||
| TERMINOLOGY | 589 | ||
| ETIOLOGY/PATHOGENESIS | 589 | ||
| CLINICAL ISSUES | 589 | ||
| IMAGING | 589 | ||
| MACROSCOPIC | 589 | ||
| MICROSCOPIC | 589 | ||
| DIFFERENTIAL DIAGNOSIS | 589 | ||
| SELECTED REFERENCES | 589 | ||
| Chapter 89. Squamous Metaplasia of Lactiferous Ducts | 590 | ||
| TERMINOLOGY | 591 | ||
| ETIOLOGY/PATHOGENESIS | 591 | ||
| CLINICAL ISSUES | 591 | ||
| IMAGING | 591 | ||
| MACROSCOPIC | 591 | ||
| MICROSCOPIC | 592 | ||
| ANCILLARY TESTS | 592 | ||
| DIFFERENTIAL DIAGNOSIS | 592 | ||
| REPORTING | 592 | ||
| SELECTED REFERENCES | 592 | ||
| Chapter 90. Granulomatous Lobular Mastitis | 596 | ||
| TERMINOLOGY | 597 | ||
| ETIOLOGY/PATHOGENESIS | 597 | ||
| CLINICAL ISSUES | 597 | ||
| IMAGING | 597 | ||
| MACROSCOPIC | 597 | ||
| MICROSCOPIC | 598 | ||
| DIFFERENTIAL DIAGNOSIS | 598 | ||
| SELECTED REFERENCES | 598 | ||
| Chapter 91. Cystic Neutrophilic Granulomatous Mastitis | 602 | ||
| TERMINOLOGY | 603 | ||
| ETIOLOGY/PATHOGENESIS | 603 | ||
| CLINICAL ISSUES | 603 | ||
| IMAGING | 603 | ||
| MICROSCOPIC | 603 | ||
| ANCILLARY TESTS | 603 | ||
| DIFFERENTIAL DIAGNOSIS | 604 | ||
| DIAGNOSTIC CHECKLIST | 604 | ||
| REPORTING | 604 | ||
| SELECTED REFERENCES | 604 | ||
| Chapter 92. Implant Pathology | 606 | ||
| TERMINOLOGY | 607 | ||
| ETIOLOGY/PATHOGENESIS | 607 | ||
| CLINICAL ISSUES | 607 | ||
| IMAGING | 608 | ||
| MACROSCOPIC | 608 | ||
| MICROSCOPIC | 608 | ||
| SELECTED REFERENCES | 609 | ||
| Chapter 93. Sarcoidosis | 614 | ||
| TERMINOLOGY | 615 | ||
| ETIOLOGY/PATHOGENESIS | 615 | ||
| CLINICAL ISSUES | 615 | ||
| IMAGING | 615 | ||
| MICROSCOPIC | 615 | ||
| DIFFERENTIAL DIAGNOSIS | 615 | ||
| SELECTED REFERENCES | 615 | ||
| Chapter 94. Amyloid of the Breast | 616 | ||
| TERMINOLOGY | 617 | ||
| ETIOLOGY/PATHOGENESIS | 617 | ||
| CLINICAL ISSUES | 617 | ||
| MICROSCOPIC | 617 | ||
| ANCILLARY TESTS | 617 | ||
| DIFFERENTIAL DIAGNOSIS | 617 | ||
| SELECTED REFERENCES | 617 | ||
| Chapter 95. Lupus Mastitis | 618 | ||
| TERMINOLOGY | 619 | ||
| ETIOLOGY/PATHOGENESIS | 619 | ||
| CLINICAL ISSUES | 619 | ||
| IMAGING | 619 | ||
| MACROSCOPIC | 619 | ||
| MICROSCOPIC | 619 | ||
| DIFFERENTIAL DIAGNOSIS | 619 | ||
| SELECTED REFERENCES | 619 | ||
| Chapter 96. IgG4-Related Sclerosing Mastitis | 620 | ||
| ETIOLOGY/PATHOGENESIS | 621 | ||
| CLINICAL ISSUES | 621 | ||
| MICROSCOPIC | 621 | ||
| ANCILLARY TESTS | 621 | ||
| DIFFERENTIAL DIAGNOSIS | 621 | ||
| SELECTED REFERENCES | 621 | ||
| SECTION 9: Other Types of Malignancies | 623 | ||
| Chapter 97. Metastases to Breast | 624 | ||
| TERMINOLOGY | 625 | ||
| CLINICAL ISSUES | 625 | ||
| IMAGING | 625 | ||
| MACROSCOPIC | 625 | ||
| MICROSCOPIC | 625 | ||
| DIFFERENTIAL DIAGNOSIS | 627 | ||
| DIAGNOSTIC CHECKLIST | 627 | ||
| SELECTED REFERENCES | 627 | ||
| Chapter 98. Lymphoma | 630 | ||
| TERMINOLOGY | 631 | ||
| ETIOLOGY/PATHOGENESIS | 631 | ||
| CLINICAL ISSUES | 631 | ||
| IMAGING | 631 | ||
| MACROSCOPIC | 631 | ||
| MICROSCOPIC | 631 | ||
| DIFFERENTIAL DIAGNOSIS | 632 | ||
| SELECTED REFERENCES | 633 | ||
| SECTION 10: Hereditary Breast Disease | 639 | ||
| Chapter 99. Hereditary Cancer | 640 | ||
| HEREDITARY BREAST CANCER | 640 | ||
| MICROSCOPIC | 642 | ||
| GENETIC TESTING FOR BRCA1 AND BRCA2 | 642 | ||
| CLINICAL MANAGEMENT | 643 | ||
| SELECTED REFERENCES | 643 | ||
| Chapter 100.\rHereditary Breast/Ovarian Cancer Syndrome: BRCA1 | 646 | ||
| TERMINOLOGY | 646 | ||
| EPIDEMIOLOGY | 646 | ||
| GENETICS | 646 | ||
| CLINICAL IMPLICATIONS | 647 | ||
| ASSOCIATED NEOPLASMS | 647 | ||
| CANCER RISK MANAGEMENT | 648 | ||
| SELECTED REFERENCES | 648 | ||
| Chapter 101.\rHereditary Breast/Ovarian Cancer Syndrome: BRCA2 | 650 | ||
| TERMINOLOGY | 650 | ||
| EPIDEMIOLOGY | 650 | ||
| GENETICS | 650 | ||
| CLINICAL IMPLICATIONS | 651 | ||
| ASSOCIATED NEOPLASMS | 651 | ||
| CANCER RISK MANAGEMENT | 652 | ||
| SELECTED REFERENCES | 652 | ||
| Chapter 102.\rLi-Fraumeni Syndrome/Li-Fraumeni-Like Syndrome | 654 | ||
| TERMINOLOGY | 654 | ||
| EPIDEMIOLOGY | 654 | ||
| GENETICS | 654 | ||
| CLINICAL IMPLICATIONS AND ANCILLARY TESTS | 655 | ||
| ASSOCIATED NEOPLASMS: TP53 | 656 | ||
| CANCER RISK MANAGEMENT | 656 | ||
| SELECTED REFERENCES | 656 | ||
| SECTION 11:\rUnusual Presentations of Breast Lesions | 659 | ||
| Chapter 103.\rBreast Carcinoma, Male | 660 | ||
| TERMINOLOGY | 661 | ||
| ETIOLOGY/PATHOGENESIS | 661 | ||
| CLINICAL ISSUES | 661 | ||
| IMAGING | 661 | ||
| MACROSCOPIC | 661 | ||
| MICROSCOPIC | 662 | ||
| ANCILLARY TESTS | 662 | ||
| DIFFERENTIAL DIAGNOSIS | 662 | ||
| DIAGNOSTIC CHECKLIST | 662 | ||
| REPORTING | 662 | ||
| SELECTED REFERENCES | 662 | ||
| Chapter 104.\rIatrogenic Changes | 664 | ||
| TERMINOLOGY | 665 | ||
| ETIOLOGY/PATHOGENESIS | 665 | ||
| IMAGING | 665 | ||
| MACROSCOPIC | 665 | ||
| MICROSCOPIC | 666 | ||
| DIFFERENTIAL DIAGNOSIS | 667 | ||
| SELECTED REFERENCES | 667 | ||
| INDEX | I-i |