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Book Details
Abstract
This is an integrated textbook on the nervous system, covering the anatomy, physiology and biochemistry of the system, all presented in a clinically relevant context appropriate for the first two years of the medical student course.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| COVER | Cover | ||
| THE NERVOUS SYSTEM: BASIC SCIENCE AND CLINICAL CONDITIONS | iii | ||
| COPYRIGHT PAGE | iv | ||
| CONTENTS | vii | ||
| CHAPTER 1 ORGANIZATION OF THE NERVOUS SYSTEM | 1 | ||
| Introduction | 2 | ||
| Overview of brain anatomy | 2 | ||
| Internal anatomy of the brain | 5 | ||
| Ventricular system | 10 | ||
| Forebrain | 11 | ||
| Hemisphere specialization | 12 | ||
| Limbic system | 14 | ||
| Orbitofrontal cortex | 17 | ||
| Basal ganglia | 17 | ||
| Diencephalon | 17 | ||
| Thalamus | 18 | ||
| Hypothalamus | 19 | ||
| Peripheral nervous system | 21 | ||
| Putting it all together: from anatomy to behaviour | 29 | ||
| CHAPTER 2 ELEMENTS OF CELLULAR AND MOLECULAR NEUROSCIENCE | 31 | ||
| Introduction | 32 | ||
| Neurones | 32 | ||
| Glial cells | 34 | ||
| Neurone excitability | 35 | ||
| Neurotransmitters | 41 | ||
| Postsynaptic events and postsynaptic receptors | 42 | ||
| CHAPTER 3 CLINICAL EXAMINATION | 47 | ||
| Introduction | 48 | ||
| Parts of the clinical examination | 48 | ||
| Other investigations | 55 | ||
| General comments | 57 | ||
| CHAPTER 4 THE SPINAL CORD | 59 | ||
| Introduction | 60 | ||
| Gross anatomy of the spinal cord and vertebral column | 60 | ||
| Functional organization of the spinal cord | 61 | ||
| Spinal cord cell types | 63 | ||
| Receptive fields | 64 | ||
| Somatosensory pathways | 65 | ||
| Blood supply to the spinal cord | 71 | ||
| Damage to the spinal cord | 72 | ||
| Comments on the case history | 78 | ||
| CHAPTER 5 PAIN AND ANALGESIA | 79 | ||
| Introduction | 80 | ||
| Nociceptors | 81 | ||
| Pain pathways | 82 | ||
| How does the central nervous system interpret a stimulus as painful? | 84 | ||
| Physiology of pain modulation | 86 | ||
| Pain mechanisms after tissue damage: peripheral and central sensitization | 90 | ||
| Neuropathic pain mechanisms | 92 | ||
| Pharmacology of pain | 93 | ||
| Other approaches to pain management | 99 | ||
| General comments on pain management | 104 | ||
| CHAPTER 6 CRANIAL NERVES AND THE BRAINSTEM | 105 | ||
| Introduction | 106 | ||
| Anatomical organization of cranial nerves in the brain | 106 | ||
| Internal organization of the brainstem | 107 | ||
| Reticular formation | 109 | ||
| Blood supply to the brainstem | 112 | ||
| Brainstem reflexes | 112 | ||
| Brainstem lesions | 116 | ||
| Comments on the case history | 118 | ||
| CHAPTER 7 THE VISUAL SYSTEM | 121 | ||
| Introduction | 122 | ||
| Structure of the eye | 122 | ||
| Visual pathways | 125 | ||
| Visual field defects | 127 | ||
| Pupillary light reflexes | 127 | ||
| Focusing of light on the retina | 127 | ||
| Control of eye movements | 130 | ||
| Structure and function of the retina | 131 | ||
| Processing of visual information | 137 | ||
| Summary | 140 | ||
| CHAPTER 8 HEARING AND BALANCE: THE AUDITORY AND VESTIBULAR SYSTEMS | 141 | ||
| Introduction | 142 | ||
| The auditory system | 142 | ||
| The vestibular system | 152 | ||
| Comments on the case history | 158 | ||
| CHAPTER 9 MOTOR SYSTEMS I: DESCENDING PATHWAYS AND CEREBELLUM | 159 | ||
| Introduction | 160 | ||
| Skeletal muscle contraction | 161 | ||
| Reflexes | 164 | ||
| Descending pathways | 167 | ||
| Clinical importance of reflexes | 172 | ||
| The cerebellum | 175 | ||
| CHAPTER 10 MOTOR SYSTEMS II: THE BASAL GANGLIA | 181 | ||
| Introduction | 182 | ||
| The basal ganglia: structure and organization | 182 | ||
| Parkinson's disease | 184 | ||
| Huntington 's disease | 194 | ||
| CHAPTER 11 STROKE AND HEAD INJURY | 199 | ||
| Introduction | 200 | ||
| Physiological control of cerebral blood flow | 200 | ||
| Blood supply to the brain | 201 | ||
| Venous system | 204 | ||
| Functional anatomy of the cerebral vasculature | 205 | ||
| Angiography | 206 | ||
| Stroke | 206 | ||
| Head injury | 219 | ||
| Comments on the case history | 225 | ||
| CHAPTER 12 INFECTION IN THE CENTRAL NERVOUS SYSTEM | 227 | ||
| Introduction | 228 | ||
| Types of infection of the central nervous system | 228 | ||
| The meninges | 229 | ||
| Cerebrospinal fluid production and circulation | 230 | ||
| The blood–brain barrier | 232 | ||
| Meningitis | 232 | ||
| Diagnosis and treatment of meningitis | 234 | ||
| Treatment of meningitis | 235 | ||
| Encephalitis | 235 | ||
| Cerebral abscesses | 235 | ||
| Brain infections in the immunocompromised patient | 236 | ||
| CHAPTER 13 EPILEPSY | 237 | ||
| Introduction | 238 | ||
| General description of epilepsy | 238 | ||
| Epidemiology of epilepsy | 238 | ||
| Types of epileptic syndrome | 239 | ||
| Diagnostic investigations of epilepsy | 239 | ||
| Different types of seizure | 242 | ||
| Neurobiology of epilepsy | 243 | ||
| Pharmacological treatment of epilepsy | 246 | ||
| Other treatments for epilepsy | 248 | ||
| Treatment of status epilepticus | 249 | ||
| Social consequences of epilepsy | 249 | ||
| CHAPTER 14 DEMENTIA | 251 | ||
| Introduction | 252 | ||
| Causes and diagnosis of dementia | 252 | ||
| Neurobiology of learning and memory | 253 | ||
| Alzheimer's disease | 256 | ||
| Treatment of Alzheimer's disease | 261 | ||
| Other types of dementia | 263 | ||
| General considerations in the management of Alzheimer's disease and other types of dementia | 265 | ||
| CHAPTER 15 SCHIZOPHRENIA | 267 | ||
| Introduction | 268 | ||
| Schizophrenia: the clinical diagnosis | 268 | ||
| Aetiology of schizophrenia | 271 | ||
| Neurobiology of schizophrenia | 272 | ||
| Treatment of schizophrenia | 275 | ||
| Comments on the management of schizophrenia and the long-term prognosis | 278 | ||
| Other psychoses and schizophrenia-like syndromes | 279 | ||
| CHAPTER 16 DEPRESSION AND ANXIETY | 281 | ||
| Introduction | 282 | ||
| Classification of mood disorders | 282 | ||
| Clinical features of mood disorders | 282 | ||
| Epidemiology of depression and natural evolution of the disease | 283 | ||
| Genetics of mood disorders | 283 | ||
| Neurobiology of depression | 286 | ||
| Treatment of depression | 287 | ||
| Bipolar disorder and its treatment | 292 | ||
| General comments on mood disorders | 293 | ||
| Need for new therapeutic targets | 294 | ||
| Comments on the case history | 294 | ||
| Anxiety disorders | 294 | ||
| Treatment of anxiety disorders | 295 | ||
| Insomnia | 297 | ||
| CHAPTER 17 ADDICTION | 301 | ||
| Introduction | 302 | ||
| Addiction and drug misuse: general comments | 302 | ||
| Opiates | 302 | ||
| Cocaine and crack | 304 | ||
| Cannabis | 305 | ||
| Nicotine | 307 | ||
| Alcohol | 308 | ||
| Phencyclidine | 309 | ||
| Amphetamines | 310 | ||
| Ecstasy—or the beginning of agony? | 310 | ||
| Hallucinogens | 311 | ||
| Solvents | 311 | ||
| Neurobiology of addiction | 312 | ||
| Addiction and rehabilitation: general issues | 313 | ||
| INDEX | 315 | ||
| A | 315 | ||
| B | 317 | ||
| C | 318 | ||
| D | 320 | ||
| E | 321 | ||
| F | 322 | ||
| G | 322 | ||
| H | 322 | ||
| I | 323 | ||
| J | 324 | ||
| K | 324 | ||
| L | 324 | ||
| M | 325 | ||
| N | 326 | ||
| O | 327 | ||
| P | 327 | ||
| Q | 329 | ||
| R | 329 | ||
| S | 329 | ||
| T | 332 | ||
| U | 332 | ||
| V | 332 | ||
| W | 333 | ||
| X | 333 | ||
| Z | 333 |