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Diagnostic Pathology: Head and Neck E-Book

Diagnostic Pathology: Head and Neck E-Book

Lester D. R. Thompson | Bruce M. Wenig

(2016)

Additional Information

Book Details

Abstract

Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of head and neck pathology. Outstanding images—including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations—make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice.

  • Thoroughly updated content throughout including new coverage of oropharyngeal carcinoma; HPV-associated, mammary analogue secretory carcinoma; EWSR1 driven tumors; molecular pathways as targets for salivary duct carcinoma; and much more
  • High-quality, carefully annotated color images (50% new!) provide clinically and diagnostically important information on more than 315 new and evolving entities of the head and neck and endocrine organs
  • State-of-the-art coverage of tumors, tumor development, and tumor genetics as well as normal histology, genetic testing, and new immunohistochemistry studies
  • Fully integrated, searchable, and linked content between differential diagnostic categories is perfectly suited for residents, while updated genetic testing algorithms, new images, and outstanding graphics make this text ideal for both residents and practitioners
  • Supporting studies are placed into clinical context, with tables and molecular flow charts that assist with management decisions and prognostic outcome predictions
  • Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index

Table of Contents

Section Title Page Action Price
Front Cover Cover
Diagnostic Pathology: Head & Neck iii
Copyright Page iv
Table of Contents xiv
Dedications v
Contributing Authors vi
Preface ix
Acknowledgments xi
Sections xiii
SECTION 1:\rNasal Cavity and Paranasal Sinuses 2
Chapter 1.\rNose and Paranasal Sinuses 4
MACROSCOPIC 4
MICROSCOPIC 4
Congenital/Genetic/Hereditary 6
Chapter 2.\rNasal Glial Heterotopia 6
TERMINOLOGY 7
ETIOLOGY/PATHOGENESIS 7
CLINICAL ISSUES 7
IMAGING 7
MACROSCOPIC 7
MICROSCOPIC 7
ANCILLARY TESTS 7
DIFFERENTIAL DIAGNOSIS 7
SELECTED REFERENCES 7
Chapter 3.\rNasal Dermoid Cyst and Sinus 8
TERMINOLOGY 9
ETIOLOGY/PATHOGENESIS 9
CLINICAL ISSUES 9
IMAGING 9
MACROSCOPIC 9
MICROSCOPIC 9
DIFFERENTIAL DIAGNOSIS 9
SELECTED REFERENCES 9
Chapter 4.\rPrimary Ciliary Dyskinesia 10
TERMINOLOGY 11
ETIOLOGY/PATHOGENESIS 11
CLINICAL ISSUES 11
MACROSCOPIC 11
ANCILLARY TESTS 11
SELECTED REFERENCES 11
Infectious 12
Chapter 5.\rAllergic Fungal Sinusitis 12
TERMINOLOGY 13
ETIOLOGY/PATHOGENESIS 13
CLINICAL ISSUES 13
IMAGING 13
MACROSCOPIC 14
MICROSCOPIC 14
ANCILLARY TESTS 14
DIFFERENTIAL DIAGNOSIS 14
DIAGNOSTIC CHECKLIST 14
SELECTED REFERENCES 14
Chapter 6.\rMycetoma 16
Chapter 7.\rRhinoscleroma 17
Chapter 8.\rInvasive Fungal Sinusitis 18
TERMINOLOGY 19
ETIOLOGY/PATHOGENESIS 19
CLINICAL ISSUES 19
MICROSCOPIC 19
ANCILLARY TESTS 19
DIFFERENTIAL DIAGNOSIS 19
SELECTED REFERENCES 19
Chapter 9.\rRhinosporidiosis 20
TERMINOLOGY 21
ETIOLOGY/PATHOGENESIS 21
CLINICAL ISSUES 21
MACROSCOPIC 21
MICROSCOPIC 21
ANCILLARY TESTS 21
DIFFERENTIAL DIAGNOSIS 21
SELECTED REFERENCES 21
Chapter 10.\rMycobacterium leprae Infection 22
TERMINOLOGY 23
ETIOLOGY/PATHOGENESIS 23
CLINICAL ISSUES 23
MICROSCOPIC 23
ANCILLARY TESTS 23
DIFFERENTIAL DIAGNOSIS 23
SELECTED REFERENCES 23
Inflammatory-Immune Dysfunction 24
Chapter 11.\rChronic Rhinosinusitis 24
TERMINOLOGY 25
ETIOLOGY/PATHOGENESIS 25
CLINICAL ISSUES 25
IMAGING 26
MICROSCOPIC 26
DIFFERENTIAL DIAGNOSIS 26
SELECTED REFERENCES 26
Chapter 12.\rGranulomatosis With Polyangiitis 28
TERMINOLOGY 29
ETIOLOGY/PATHOGENESIS 29
CLINICAL ISSUES 29
MACROSCOPIC 30
MICROSCOPIC 30
ANCILLARY TESTS 31
DIFFERENTIAL DIAGNOSIS 31
DIAGNOSTIC CHECKLIST 31
SELECTED REFERENCES 31
Chapter 13. Eosinophilic Angiocentric Fibrosis 34
TERMINOLOGY 35
ETIOLOGY/PATHOGENESIS 35
CLINICAL ISSUES 35
MICROSCOPIC 35
ANCILLARY TESTS 35
DIFFERENTIAL DIAGNOSIS 35
SELECTED REFERENCES 35
Reactive 36
Chapter 14.\rSinonasal Inflammatory Polyp 36
TERMINOLOGY 37
ETIOLOGY/PATHOGENESIS 37
CLINICAL ISSUES 37
IMAGING 37
MACROSCOPIC 37
MICROSCOPIC 37
DIFFERENTIAL DIAGNOSIS 38
SELECTED REFERENCES 38
Chapter 15.\rAntrochoanal Polyp 40
TERMINOLOGY 41
ETIOLOGY/PATHOGENESIS 41
CLINICAL ISSUES 41
MACROSCOPIC 41
MICROSCOPIC 41
ANCILLARY TESTS 41
DIFFERENTIAL DIAGNOSIS 41
SELECTED REFERENCES 41
Chapter 16. Sinonasal Hamartoma 42
TERMINOLOGY 43
ETIOLOGY/PATHOGENESIS 43
CLINICAL ISSUES 43
MACROSCOPIC 43
MICROSCOPIC 44
ANCILLARY TESTS 44
DIFFERENTIAL DIAGNOSIS 45
SELECTED REFERENCES 45
Chapter 17.\rMucocele of Paranasal Sinus 48
TERMINOLOGY 49
ETIOLOGY/PATHOGENESIS 49
CLINICAL ISSUES 49
IMAGING 49
MACROSCOPIC 49
MICROSCOPIC 49
DIFFERENTIAL DIAGNOSIS 49
SELECTED REFERENCES 49
Chapter 18.\rExtranodal Sinus Histiocytosis With Massive Lymphadenopathy 50
TERMINOLOGY 51
ETIOLOGY/PATHOGENESIS 51
CLINICAL ISSUES 51
MACROSCOPIC 51
MICROSCOPIC 51
ANCILLARY TESTS 52
DIFFERENTIAL DIAGNOSIS 52
SELECTED REFERENCES 52
Chapter 19.\rMyospherulosis 54
TERMINOLOGY 55
ETIOLOGY/PATHOGENESIS 55
CLINICAL ISSUES 55
IMAGING 55
MICROSCOPIC 55
ANCILLARY TESTS 55
DIFFERENTIAL DIAGNOSIS 55
SELECTED REFERENCES 55
Benign Neoplasm 56
Chapter 20.\rSinonasal (Schneiderian) Papilloma 56
TERMINOLOGY 57
ETIOLOGY/PATHOGENESIS 57
CLINICAL ISSUES 57
IMAGING 57
MACROSCOPIC 58
MICROSCOPIC 58
ANCILLARY TESTS 58
DIFFERENTIAL DIAGNOSIS 59
SELECTED REFERENCES 59
Chapter 21.\rSiomorphic Adenoma 64
TERMINOLOGY 65
CLINICAL ISSUES 65
IMAGING 65
MACROSCOPIC 65
MICROSCOPIC 65
ANCILLARY TESTS 65
DIFFERENTIAL DIAGNOSIS 65
SELECTED REFERENCES 65
Chapter 22.\rEctopic Pituitary Adenoma 66
TERMINOLOGY 67
ETIOLOGY/PATHOGENESIS 67
CLINICAL ISSUES 67
IMAGING 67
MACROSCOPIC 67
MICROSCOPIC 67
ANCILLARY TESTS 68
DIFFERENTIAL DIAGNOSIS 68
DIAGNOSTIC CHECKLIST 68
SELECTED REFERENCES 68
Chapter 23.\rMeningioma 72
TERMINOLOGY 73
ETIOLOGY/PATHOGENESIS 73
CLINICAL ISSUES 73
IMAGING 73
MACROSCOPIC 73
MICROSCOPIC 73
ANCILLARY TESTS 73
DIFFERENTIAL DIAGNOSIS 73
SELECTED REFERENCES 73
Chapter 24.\rAmeloblastoma 74
TERMINOLOGY 75
CLINICAL ISSUES 75
IMAGING 75
MACROSCOPIC 75
MICROSCOPIC 75
DIFFERENTIAL DIAGNOSIS 75
SELECTED REFERENCES 75
Chapter 25.\rLobular Capillary Hemangioma (Pyogenic Granuloma) 76
TERMINOLOGY 77
ETIOLOGY/PATHOGENESIS 77
CLINICAL ISSUES 77
IMAGING 77
MACROSCOPIC 77
MICROSCOPIC 78
ANCILLARY TESTS 78
DIFFERENTIAL DIAGNOSIS 78
SELECTED REFERENCES 78
Chapter 26.\rSchwannoma/Neurofibroma 80
TERMINOLOGY 81
ETIOLOGY/PATHOGENESIS 81
CLINICAL ISSUES 81
IMAGING 81
MACROSCOPIC 81
MICROSCOPIC 81
ANCILLARY TESTS 81
DIFFERENTIAL DIAGNOSIS 81
SELECTED REFERENCES 81
Chapter 27.\rLeiomyoma and Smooth Muscle Tumors of Uncertain Malignant Potential 84
TERMINOLOGY 85
ETIOLOGY/PATHOGENESIS 85
CLINICAL ISSUES 85
MACROSCOPIC 85
MICROSCOPIC 85
ANCILLARY TESTS 85
DIFFERENTIAL DIAGNOSIS 85
SELECTED REFERENCES 85
Chapter 28.\rFibromatosis/Desmoid-Type Fibromatosis 88
TERMINOLOGY 89
ETIOLOGY/PATHOGENESIS 89
CLINICAL ISSUES 89
MACROSCOPIC 89
MICROSCOPIC 89
ANCILLARY TESTS 89
DIFFERENTIAL DIAGNOSIS 89
SELECTED REFERENCES 89
Chapter 29.\rSolitary Fibrous Tumor 90
TERMINOLOGY 91
CLINICAL ISSUES 91
IMAGING 91
MACROSCOPIC 91
MICROSCOPIC 91
ANCILLARY TESTS 91
DIFFERENTIAL DIAGNOSIS 92
SELECTED REFERENCES 92
Chapter 30.\rMyxoma/Fibromyxoma 94
TERMINOLOGY 95
ETIOLOGY/PATHOGENESIS 95
CLINICAL ISSUES 95
MACROSCOPIC 95
MICROSCOPIC 95
ANCILLARY TESTS 95
DIFFERENTIAL DIAGNOSIS 95
SELECTED REFERENCES 95
Borderline Neoplasm 96
Chapter 31.\rGlomangiopericytoma 96
TERMINOLOGY 97
ETIOLOGY/PATHOGENESIS 97
CLINICAL ISSUES 97
IMAGING 97
MACROSCOPIC 97
MICROSCOPIC 97
ANCILLARY TESTS 98
DIFFERENTIAL DIAGNOSIS 98
SELECTED REFERENCES 98
Malignant Neoplasm 100
Chapter 32.\rSquamous Cell Carcinoma 100
TERMINOLOGY 101
ETIOLOGY/PATHOGENESIS 101
CLINICAL ISSUES 101
IMAGING 102
MACROSCOPIC 102
MICROSCOPIC 102
ANCILLARY TESTS 102
DIFFERENTIAL DIAGNOSIS 103
SELECTED REFERENCES 103
Chapter 33.\rSinonasal Undifferentiated Carcinoma 106
TERMINOLOGY 107
ETIOLOGY/PATHOGENESIS 107
CLINICAL ISSUES 107
IMAGING 108
MACROSCOPIC 108
MICROSCOPIC 108
ANCILLARY TESTS 108
DIFFERENTIAL DIAGNOSIS 108
SELECTED REFERENCES 109
Chapter 34.\rLymphoepithelial Carcinoma 112
TERMINOLOGY 113
ETIOLOGY/PATHOGENESIS 113
CLINICAL ISSUES 113
MICROSCOPIC 113
ANCILLARY TESTS 113
DIFFERENTIAL DIAGNOSIS 113
SELECTED REFERENCES 113
Chapter 35.\rSinonasal Adenocarcinoma, Intestinal Type 114
TERMINOLOGY 115
ETIOLOGY/PATHOGENESIS 115
CLINICAL ISSUES 115
IMAGING 115
MICROSCOPIC 115
ANCILLARY TESTS 116
DIFFERENTIAL DIAGNOSIS 116
SELECTED REFERENCES 117
Chapter 36. Sinonasal Nonintestinal-Nonsalivary Adenocarcinoma 120
TERMINOLOGY 121
ETIOLOGY/PATHOGENESIS 121
CLINICAL ISSUES 121
MICROSCOPIC 121
ANCILLARY TESTS 122
DIFFERENTIAL DIAGNOSIS 122
SELECTED REFERENCES 122
Chapter 37.\rOlfactory Neuroblastoma 124
TERMINOLOGY 125
ETIOLOGY/PATHOGENESIS 125
CLINICAL ISSUES 125
IMAGING 126
MACROSCOPIC 126
MICROSCOPIC 126
ANCILLARY TESTS 126
DIFFERENTIAL DIAGNOSIS 127
SELECTED REFERENCES 127
Chapter 38.\rMalignant Mucosal Melanoma 134
TERMINOLOGY 135
ETIOLOGY/PATHOGENESIS 135
CLINICAL ISSUES 135
IMAGING 135
MACROSCOPIC 135
MICROSCOPIC 135
ANCILLARY TESTS 136
DIFFERENTIAL DIAGNOSIS 136
SELECTED REFERENCES 136
Chapter 39.\rEwing Sarcoma, Including Sinonasal Adamantinoma-Like 140
TERMINOLOGY 141
ETIOLOGY/PATHOGENESIS 141
CLINICAL ISSUES 141
IMAGING 141
MACROSCOPIC 141
MICROSCOPIC 142
ANCILLARY TESTS 142
DIFFERENTIAL DIAGNOSIS 142
STAGING 143
SELECTED REFERENCES 143
Chapter 40.\rTeratocarcinosarcoma 146
TERMINOLOGY 147
ETIOLOGY/PATHOGENESIS 147
CLINICAL ISSUES 147
IMAGING 147
MACROSCOPIC 147
MICROSCOPIC 147
ANCILLARY TESTS 148
DIFFERENTIAL DIAGNOSIS 148
DIAGNOSTIC CHECKLIST 148
SELECTED REFERENCES 148
Chapter 41.\rFibrosarcoma 150
TERMINOLOGY 151
ETIOLOGY/PATHOGENESIS 151
CLINICAL ISSUES 151
IMAGING 151
MACROSCOPIC 151
MICROSCOPIC 151
ANCILLARY TESTS 152
DIFFERENTIAL DIAGNOSIS 152
SELECTED REFERENCES 152
Chapter 42.\rLeiomyosarcoma 154
TERMINOLOGY 155
ETIOLOGY/PATHOGENESIS 155
CLINICAL ISSUES 155
IMAGING 155
MACROSCOPIC 155
MICROSCOPIC 155
ANCILLARY TESTS 156
DIFFERENTIAL DIAGNOSIS 156
SELECTED REFERENCES 156
Chapter 43.\rMalignant Peripheral Nerve Sheath Tumor 158
TERMINOLOGY 159
ETIOLOGY/PATHOGENESIS 159
CLINICAL ISSUES 159
MACROSCOPIC 159
MICROSCOPIC 159
ANCILLARY TESTS 160
DIFFERENTIAL DIAGNOSIS 160
SELECTED REFERENCES 160
Chapter 44.\rUndifferentiated Pleomorphic Sarcoma 162
TERMINOLOGY 163
ETIOLOGY/PATHOGENESIS 163
CLINICAL ISSUES 163
MACROSCOPIC 163
MICROSCOPIC 163
ANCILLARY TESTS 164
DIFFERENTIAL DIAGNOSIS 164
DIAGNOSTIC CHECKLIST 164
SELECTED REFERENCES 164
Chapter 45.\rMesenchymal Chondrosarcoma 166
TERMINOLOGY 167
CLINICAL ISSUES 167
IMAGING 167
MACROSCOPIC 167
MICROSCOPIC 167
ANCILLARY TESTS 167
DIFFERENTIAL DIAGNOSIS 167
SELECTED REFERENCES 167
Chapter 46.\rAngiosarcoma 168
TERMINOLOGY 169
ETIOLOGY/PATHOGENESIS 169
CLINICAL ISSUES 169
IMAGING 169
MACROSCOPIC 169
MICROSCOPIC 169
ANCILLARY TESTS 169
DIFFERENTIAL DIAGNOSIS 169
SELECTED REFERENCES 170
Chapter 47.\rExtranodal NK-/T-Cell Lymphoma, Nasal Type 172
TERMINOLOGY 173
ETIOLOGY/PATHOGENESIS 173
CLINICAL ISSUES 173
IMAGING 174
MICROSCOPIC 174
ANCILLARY TESTS 174
DIFFERENTIAL DIAGNOSIS 175
DIAGNOSTIC CHECKLIST 175
SELECTED REFERENCES 175
Chapter 48.\rBiphenotypic Sinonasal Sarcoma 178
TERMINOLOGY 179
CLINICAL ISSUES 179
MICROSCOPIC 179
ANCILLARY TESTS 179
DIFFERENTIAL DIAGNOSIS 179
SELECTED REFERENCES 179
Chapter 49.\rNUT Midline Carcinoma 180
TERMINOLOGY 181
ETIOLOGY/PATHOGENESIS 181
CLINICAL ISSUES 181
MICROSCOPIC 181
ANCILLARY TESTS 181
DIFFERENTIAL DIAGNOSIS 181
DIAGNOSTIC CHECKLIST 181
SELECTED REFERENCES 181
Chapter 50.\rHPV-Related Carcinoma With Adenoid Cystic-Like Features 182
TERMINOLOGY 183
CLINICAL ISSUES 183
MACROSCOPIC 183
MICROSCOPIC 183
ANCILLARY TESTS 183
DIFFERENTIAL DIAGNOSIS 183
SELECTED REFERENCES 183
Chapter 51.\rSinonasal Renal Cell-Like Adenocarcinoma 184
TERMINOLOGY 185
CLINICAL ISSUES 185
MACROSCOPIC 185
MICROSCOPIC 185
ANCILLARY TESTS 185
DIFFERENTIAL DIAGNOSIS 185
DIAGNOSTIC CHECKLIST 185
SELECTED REFERENCES 185
Chapter 52.\rMetastatic/Secondary Tumors 186
TERMINOLOGY 187
CLINICAL ISSUES 187
MACROSCOPIC 187
MICROSCOPIC 187
ANCILLARY TESTS 187
DIFFERENTIAL DIAGNOSIS 187
SELECTED REFERENCES 187
Specimen Examination, Nasal Cavity & Paranasal Sinuses 188
Chapter 53.\rSpecimen Examination and Staging Tools, Nasal Cavity and Paranasal Sinus 188
PRIMARY TUMOR 188
REGIONAL LYMPH NODES 188
PROGNOSTIC GROUPS 188
SECTION 2:\rPharynx (Nasal, Oro-, Hypo-) 191
Chapter 54.\rPharynx 192
MACROSCOPIC ANATOMY 192
MICROSCOPIC ANATOMY 192
PITFALLS 192
Congenital/Genetic/Hereditary 194
Chapter 55.\rDermoid Cyst 194
TERMINOLOGY 195
CLINICAL ISSUES 195
MACROSCOPIC 195
MICROSCOPIC 195
DIFFERENTIAL DIAGNOSIS 195
SELECTED REFERENCES 195
Chapter 56.\rRathke Cleft Cyst 196
SECTION 3:\rLarynx and Trachea 236
Chapter 70.\rLarynx 238
MACROSCOPIC ANATOMY 238
MICROSCOPIC ANATOMY 238
VARIATIONS 238
Congenital/Genetic/Hereditary 240
Chapter 71.\rLaryngocele and Laryngeal Cysts 240
TERMINOLOGY 241
ETIOLOGY/PATHOGENESIS 241
CLINICAL ISSUES 241
IMAGING 241
MACROSCOPIC 241
MICROSCOPIC 241
DIFFERENTIAL DIAGNOSIS 241
SELECTED REFERENCES 241
Chapter 72.\rTracheopathia Osteoplastica 242
TERMINOLOGY 243
ETIOLOGY/PATHOGENESIS 243
CLINICAL ISSUES 243
IMAGING 243
MACROSCOPIC 243
MICROSCOPIC 243
DIFFERENTIAL DIAGNOSIS 243
SELECTED REFERENCES 243
Infectious 244
Chapter 72.\rLaryngitis: Viral, Bacterial, Fungal 244
TERMINOLOGY 245
ETIOLOGY/PATHOGENESIS 245
CLINICAL ISSUES 245
MICROSCOPIC 245
ANCILLARY TESTS 245
DIFFERENTIAL DIAGNOSIS 245
SELECTED REFERENCES 245
Reactive 248
Chapter 73.\rVocal Cord Nodules and Polyps 248
TERMINOLOGY 249
ETIOLOGY/PATHOGENESIS 249
CLINICAL ISSUES 249
MACROSCOPIC 249
MICROSCOPIC 250
DIFFERENTIAL DIAGNOSIS 250
SELECTED REFERENCES 250
Chapter 74.\rReactive Epithelial Changes 252
TERMINOLOGY 253
ETIOLOGY/PATHOGENESIS 253
CLINICAL ISSUES 253
MACROSCOPIC 253
MICROSCOPIC 253
DIFFERENTIAL DIAGNOSIS 253
SELECTED REFERENCES 253
Chapter 75.\rContact Ulcer 256
TERMINOLOGY 257
ETIOLOGY/PATHOGENESIS 257
CLINICAL ISSUES 257
MACROSCOPIC 257
MICROSCOPIC 257
DIFFERENTIAL DIAGNOSIS 257
DIAGNOSTIC CHECKLIST 257
SELECTED REFERENCES 257
Benign Neoplasm 258
Chapter 76.\rSquamous Papilloma 258
TERMINOLOGY 259
ETIOLOGY/PATHOGENESIS 259
CLINICAL ISSUES 259
MACROSCOPIC 260
MICROSCOPIC 260
ANCILLARY TESTS 260
DIFFERENTIAL DIAGNOSIS 260
REPORTING 260
SELECTED REFERENCES 260
Chapter 77.\rGranular Cell Tumor 262
TERMINOLOGY 263
CLINICAL ISSUES 263
MACROSCOPIC 263
MICROSCOPIC 263
ANCILLARY TESTS 263
DIFFERENTIAL DIAGNOSIS 263
SELECTED REFERENCES 263
Chapter 78.\rAmyloid (Amyloidoma) 264
TERMINOLOGY 265
ETIOLOGY/PATHOGENESIS 265
CLINICAL ISSUES 265
MACROSCOPIC 265
MICROSCOPIC 265
ANCILLARY TESTS 265
DIFFERENTIAL DIAGNOSIS 265
SELECTED REFERENCES 265
Chapter 79.\rRhabdomyoma 266
TERMINOLOGY 267
ETIOLOGY/PATHOGENESIS 267
CLINICAL ISSUES 267
MACROSCOPIC 267
MICROSCOPIC 267
ANCILLARY TESTS 268
DIFFERENTIAL DIAGNOSIS 268
SELECTED REFERENCES 268
Chapter 80.\rChondroma 270
TERMINOLOGY 271
ETIOLOGY/PATHOGENESIS 271
CLINICAL ISSUES 271
IMAGING 271
MACROSCOPIC 271
MICROSCOPIC 271
DIFFERENTIAL DIAGNOSIS 271
SELECTED REFERENCES 271
Chapter 81.\rInflammatory Myofibroblastic Tumor 272
TERMINOLOGY 273
ETIOLOGY/PATHOGENESIS 273
CLINICAL ISSUES 273
MACROSCOPIC 273
MICROSCOPIC 273
ANCILLARY TESTS 274
DIFFERENTIAL DIAGNOSIS 274
SELECTED REFERENCES 274
Chapter 82.\rParaganglioma 276
TERMINOLOGY 277
CLINICAL ISSUES 277
MACROSCOPIC 277
MICROSCOPIC 277
DIFFERENTIAL DIAGNOSIS 277
SELECTED REFERENCES 277
Malignant Neoplasm 278
Chapter 83.\rKeratinizing Dysplasia and Carcinoma In Situ 278
TERMINOLOGY 279
ETIOLOGY/PATHOGENESIS 279
CLINICAL ISSUES 279
MACROSCOPIC 280
MICROSCOPIC 280
ANCILLARY TESTS 281
DIFFERENTIAL DIAGNOSIS 281
SELECTED REFERENCES 282
Chapter 84.\rConventional Squamous Cell Carcinoma 286
TERMINOLOGY 287
ETIOLOGY/PATHOGENESIS 287
CLINICAL ISSUES 287
MACROSCOPIC 289
MICROSCOPIC 289
DIFFERENTIAL DIAGNOSIS 290
SELECTED REFERENCES 290
Chapter 85.\rVerrucous Carcinoma 294
TERMINOLOGY 295
ETIOLOGY/PATHOGENESIS 295
CLINICAL ISSUES 295
MACROSCOPIC 295
MICROSCOPIC 295
ANCILLARY TESTS 296
DIFFERENTIAL DIAGNOSIS 296
SELECTED REFERENCES 296
Chapter 86.\rSpindle Cell \"Sarcomatoid\" Squamous Cell Carcinoma 298
TERMINOLOGY 299
ETIOLOGY/PATHOGENESIS 299
CLINICAL ISSUES 299
MACROSCOPIC 299
MICROSCOPIC 299
ANCILLARY TESTS 299
DIFFERENTIAL DIAGNOSIS 299
DIAGNOSTIC CHECKLIST 300
STAGING 300
SELECTED REFERENCES 300
Chapter 87.\rBasaloid Squamous Cell Carcinoma 304
TERMINOLOGY 305
ETIOLOGY/PATHOGENESIS 305
CLINICAL ISSUES 305
MACROSCOPIC 305
MICROSCOPIC 305
ANCILLARY TESTS 305
DIFFERENTIAL DIAGNOSIS 305
SELECTED REFERENCES 305
Chapter 88.\rExophytic and Papillary Squamous Cell Carcinoma 306
TERMINOLOGY 307
ETIOLOGY/PATHOGENESIS 307
CLINICAL ISSUES 307
MACROSCOPIC 307
MICROSCOPIC 307
DIFFERENTIAL DIAGNOSIS 307
SELECTED REFERENCES 307
Chapter 89.\rAdenosquamous Carcinoma 310
TERMINOLOGY 311
ETIOLOGY/PATHOGENESIS 311
CLINICAL ISSUES 311
MACROSCOPIC 311
MICROSCOPIC 311
ANCILLARY TESTS 312
DIFFERENTIAL DIAGNOSIS 312
SELECTED REFERENCES 312
Chapter 90.\rNeuroendocrine Carcinoma 314
TERMINOLOGY 315
ETIOLOGY/PATHOGENESIS 315
CLINICAL ISSUES 315
MACROSCOPIC 316
MICROSCOPIC 316
ANCILLARY TESTS 316
DIFFERENTIAL DIAGNOSIS 316
SELECTED REFERENCES 317
Chapter 91.\rChondrosarcoma 322
TERMINOLOGY 323
ETIOLOGY/PATHOGENESIS 323
CLINICAL ISSUES 323
IMAGING 323
MACROSCOPIC 323
MICROSCOPIC 323
DIFFERENTIAL DIAGNOSIS 323
GRADING 323
SELECTED REFERENCES 323
Chapter 92.\rMetastatic/Secondary Tumors 326
TERMINOLOGY 327
CLINICAL ISSUES 327
MACROSCOPIC 327
MICROSCOPIC 327
DIFFERENTIAL DIAGNOSIS 327
SELECTED REFERENCES 327
SECTION 4: Oral Cavity 330
Chapter 94.\rOral Mucosae 332
MACROSCOPIC ANATOMY 332
MICROSCOPIC ANATOMY 332
VARIATIONS 332
SELECTED REFERENCES 332
Chapter 95.\rTongue 334
MACROSCOPIC ANATOMY 334
MICROSCOPIC ANATOMY 334
PITFALLS/ARTIFACTS 334
Congenital/Genetic/Hereditary 336
Chapter 96.\rEctopic (Lingual) Thyroid 336
TERMINOLOGY 337
ETIOLOGY/PATHOGENESIS 337
CLINICAL ISSUES 337
MICROSCOPIC 337
ANCILLARY TESTS 337
DIFFERENTIAL DIAGNOSIS 337
DIAGNOSTIC CHECKLIST 337
SELECTED REFERENCES 337
Chapter 97.\rWhite Sponge Nevus 338
Infectious 339
Chapter 98.\rFocal Epithelial Hyperplasia (Heck Disease) 339
Chapter 99.\rHairy Leukoplakia 340
TERMINOLOGY 341
ETIOLOGY/PATHOGENESIS 341
CLINICAL ISSUES 341
MICROSCOPIC 341
ANCILLARY TESTS 341
DIFFERENTIAL DIAGNOSIS 341
DIAGNOSTIC CHECKLIST 341
SELECTED REFERENCES 341
Chapter 100.\rOral Infections 342
TERMINOLOGY 343
ETIOLOGY/PATHOGENESIS 343
CLINICAL ISSUES 343
MICROSCOPIC 344
DIFFERENTIAL DIAGNOSIS 344
SELECTED REFERENCES 344
Inflammatory-Immune Dysfunction 346
Chapter 101.\rAphthous Stomatitis 346
TERMINOLOGY 347
ETIOLOGY/PATHOGENESIS 347
CLINICAL ISSUES 347
MICROSCOPIC 347
DIFFERENTIAL DIAGNOSIS 347
DIAGNOSTIC CHECKLIST 348
SELECTED REFERENCES 348
Chapter 102.\rPemphigus Vulgaris 350
TERMINOLOGY 351
ETIOLOGY/PATHOGENESIS 351
CLINICAL ISSUES 351
MICROSCOPIC 351
ANCILLARY TESTS 351
DIFFERENTIAL DIAGNOSIS 351
DIAGNOSTIC CHECKLIST 351
SELECTED REFERENCES 351
Chapter 103.\rMucous Membrane Pemphigoid 352
TERMINOLOGY 353
ETIOLOGY/PATHOGENESIS 353
CLINICAL ISSUES 353
MICROSCOPIC 353
DIFFERENTIAL DIAGNOSIS 353
DIAGNOSTIC CHECKLIST 353
SELECTED REFERENCES 353
Chapter 104.\rOral Lichen Planus 354
TERMINOLOGY 355
ETIOLOGY/PATHOGENESIS 355
CLINICAL ISSUES 355
MICROSCOPIC 355
DIFFERENTIAL DIAGNOSIS 355
DIAGNOSTIC CHECKLIST 356
SELECTED REFERENCES 356
Chapter 105.\rErythema Multiforme 358
TERMINOLOGY 359
ETIOLOGY/PATHOGENESIS 359
CLINICAL ISSUES 359
MICROSCOPIC 359
ANCILLARY TESTS 359
DIFFERENTIAL DIAGNOSIS 359
DIAGNOSTIC CHECKLIST 359
SELECTED REFERENCES 359
Chapter 106.\rLupus Erythematosus 360
TERMINOLOGY 361
ETIOLOGY/PATHOGENESIS 361
CLINICAL ISSUES 361
MICROSCOPIC 362
ANCILLARY TESTS 362
DIFFERENTIAL DIAGNOSIS 362
DIAGNOSTIC CHECKLIST 362
SELECTED REFERENCES 362
Reactive 364
Chapter 107.\rTraumatic Ulcerative Granuloma 364
TERMINOLOGY 365
ETIOLOGY/PATHOGENESIS 365
CLINICAL ISSUES 365
MICROSCOPIC 365
DIFFERENTIAL DIAGNOSIS 365
SELECTED REFERENCES 365
Chapter 108.\rFrictional Hyperkeratosis 366
Chapter 109.\rPseudoepitheliomatous Hyperplasia 367
Chapter 110.\rNecrotizing Sialometaplasia 368
TERMINOLOGY 369
ETIOLOGY/PATHOGENESIS 369
CLINICAL ISSUES 369
MACROSCOPIC 369
MICROSCOPIC 369
DIFFERENTIAL DIAGNOSIS 369
SELECTED REFERENCES 369
Chapter 111.\rLymphangiomatous Polyp 370
TERMINOLOGY 371
ETIOLOGY/PATHOGENESIS 371
CLINICAL ISSUES 371
MACROSCOPIC 371
MICROSCOPIC 371
ANCILLARY TESTS 371
DIFFERENTIAL DIAGNOSIS 371
SELECTED REFERENCES 371
Chapter 112. Tobacco Changes 372
TERMINOLOGY 373
ETIOLOGY/PATHOGENESIS 373
CLINICAL ISSUES 373
MICROSCOPIC 373
DIFFERENTIAL DIAGNOSIS 373
DIAGNOSTIC CHECKLIST 373
SELECTED REFERENCES 373
Chapter 1113.\rAmalgam Tattoo 374
Nonneoplastic Lesions 375
Chapter 114.\rFordyce Granules 375
Chapter 115.\rHairy Tongue 376
Chapter 116.\rJuxtaoral Organ of Chievitz 377
Chapter 117.\rVerruciform Xanthoma 378
Chapter 118.\rHeterotopic Salivary Glands 379
Chapter 119.\rGeographic Tongue 380
TERMINOLOGY 381
ETIOLOGY/PATHOGENESIS 381
CLINICAL ISSUES 381
MACROSCOPIC 381
MICROSCOPIC 381
DIFFERENTIAL DIAGNOSIS 381
SELECTED REFERENCES 381
Chapter 120.\rMucocele and Ranula 382
TERMINOLOGY 383
ETIOLOGY/PATHOGENESIS 383
CLINICAL ISSUES 383
MACROSCOPIC 383
MICROSCOPIC 383
DIFFERENTIAL DIAGNOSIS 383
SELECTED REFERENCES 383
Benign Neoplasm 384
Chapter 121.\rSquamous Papilloma (Including Verruca and Condyloma) 384
TERMINOLOGY 385
ETIOLOGY/PATHOGENESIS 385
CLINICAL ISSUES 385
MACROSCOPIC 385
MICROSCOPIC 386
ANCILLARY TESTS 386
DIFFERENTIAL DIAGNOSIS 386
DIAGNOSTIC CHECKLIST 386
SELECTED REFERENCES 386
Chapter 122.\rGranular Cell Tumor 388
TERMINOLOGY 389
ETIOLOGY/PATHOGENESIS 389
CLINICAL ISSUES 389
MACROSCOPIC 389
MICROSCOPIC 389
ANCILLARY TESTS 389
DIFFERENTIAL DIAGNOSIS 389
SELECTED REFERENCES 390
Chapter 123.\rCongenital Granular Cell Epulis 392
TERMINOLOGY 393
ETIOLOGY/PATHOGENESIS 393
CLINICAL ISSUES 393
IMAGING 393
MACROSCOPIC 393
MICROSCOPIC 393
ANCILLARY TESTS 393
DIFFERENTIAL DIAGNOSIS 393
DIAGNOSTIC CHECKLIST 393
SELECTED REFERENCES 393
Chapter 124.\rPyogenic Granuloma 394
TERMINOLOGY 395
ETIOLOGY/PATHOGENESIS 395
CLINICAL ISSUES 395
MACROSCOPIC 395
MICROSCOPIC 395
DIFFERENTIAL DIAGNOSIS 395
SELECTED REFERENCES 395
Chapter 125.\rPeripheral Giant Cell Granuloma 396
TERMINOLOGY 397
ETIOLOGY/PATHOGENESIS 397
CLINICAL ISSUES 397
IMAGING 397
MACROSCOPIC 397
MICROSCOPIC 397
DIFFERENTIAL DIAGNOSIS 397
SELECTED REFERENCES 397
Chapter 126.\rFibroma 398
TERMINOLOGY 399
ETIOLOGY/PATHOGENESIS 399
CLINICAL ISSUES 399
MACROSCOPIC 399
MICROSCOPIC 399
DIFFERENTIAL DIAGNOSIS 399
SELECTED REFERENCES 399
Chapter 127.\rPeripheral Ossifying Fibroma 400
TERMINOLOGY 401
ETIOLOGY/PATHOGENESIS 401
CLINICAL ISSUES 401
MACROSCOPIC 401
MICROSCOPIC 401
DIFFERENTIAL DIAGNOSIS 401
SELECTED REFERENCES 401
Chapter 128.\rMucosal Neuroma 402
TERMINOLOGY 403
ETIOLOGY/PATHOGENESIS 403
CLINICAL ISSUES 403
MACROSCOPIC 403
MICROSCOPIC 403
ANCILLARY TESTS 403
DIFFERENTIAL DIAGNOSIS 403
DIAGNOSTIC CHECKLIST 403
SELECTED REFERENCES 403
Chapter 129.\rAcquired Melanocytic Nevus 404
TERMINOLOGY 405
ETIOLOGY/PATHOGENESIS 405
CLINICAL ISSUES 405
MICROSCOPIC 405
DIFFERENTIAL DIAGNOSIS 405
SELECTED REFERENCES 405
Chapter 130.\rTeratoma 408
TERMINOLOGY 409
ETIOLOGY/PATHOGENESIS 409
CLINICAL ISSUES 409
IMAGING 409
MACROSCOPIC 409
MICROSCOPIC 409
DIFFERENTIAL DIAGNOSIS 409
SELECTED REFERENCES 409
Chapter 131.\rEctomesenchymal Chondromyxoid Tumor 410
TERMINOLOGY 411
CLINICAL ISSUES 411
MACROSCOPIC 411
MICROSCOPIC 411
DIFFERENTIAL DIAGNOSIS 411
SELECTED REFERENCES 411
Malignant Neoplasm 412
Chapter 132.\rDysplasia and Carcinoma In Situ 412
TERMINOLOGY 413
ETIOLOGY/PATHOGENESIS 413
CLINICAL ISSUES 413
MACROSCOPIC 413
MICROSCOPIC 414
DIFFERENTIAL DIAGNOSIS 414
SELECTED REFERENCES 414
Chapter 133.\rProliferative Verrucous Leukoplakia 418
TERMINOLOGY 419
ETIOLOGY/PATHOGENESIS 419
CLINICAL ISSUES 419
MICROSCOPIC 419
DIFFERENTIAL DIAGNOSIS 419
DIAGNOSTIC CHECKLIST 419
SELECTED REFERENCES 419
Chapter 134.\rSquamous Cell Carcinoma 420
TERMINOLOGY 421
ETIOLOGY/PATHOGENESIS 421
CLINICAL ISSUES 421
IMAGING 422
MACROSCOPIC 422
MICROSCOPIC 422
ANCILLARY TESTS 423
DIFFERENTIAL DIAGNOSIS 423
DIAGNOSTIC CHECKLIST 423
SELECTED REFERENCES 423
Chapter 135.\rOropharyngeal Carcinoma 426
TERMINOLOGY 427
ETIOLOGY/PATHOGENESIS 427
CLINICAL ISSUES 427
IMAGING 427
MACROSCOPIC 427
MICROSCOPIC 427
ANCILLARY TESTS 428
DIFFERENTIAL DIAGNOSIS 428
DIAGNOSTIC CHECKLIST 428
SELECTED REFERENCES 428
Chapter 136.\rMelanoma 430
TERMINOLOGY 431
ETIOLOGY/PATHOGENESIS 431
CLINICAL ISSUES 431
IMAGING 431
MACROSCOPIC 431
MICROSCOPIC 431
ANCILLARY TESTS 432
DIFFERENTIAL DIAGNOSIS 432
SELECTED REFERENCES 432
Chapter 137.\rAngiosarcoma 434
TERMINOLOGY 435
ETIOLOGY/PATHOGENESIS 435
CLINICAL ISSUES 435
MACROSCOPIC 435
MICROSCOPIC 435
DIFFERENTIAL DIAGNOSIS 435
SELECTED REFERENCES 435
Chapter 138.\rKaposi Sarcoma 436
TERMINOLOGY 437
ETIOLOGY/PATHOGENESIS 437
CLINICAL ISSUES 437
MICROSCOPIC 437
ANCILLARY TESTS 437
DIFFERENTIAL DIAGNOSIS 437
SELECTED REFERENCES 437
Chapter 139.\rMetastatic/Secondary Tumors 438
TERMINOLOGY 439
ETIOLOGY/PATHOGENESIS 439
CLINICAL ISSUES 439
MICROSCOPIC 439
ANCILLARY TESTS 439
DIFFERENTIAL DIAGNOSIS 439
SELECTED REFERENCES 439
Specimen Examination, Lip and Oral Cavity 440
Chapter 140.\rSpecimen Examination and Staging Tools, Lip and Oral Cavity 440
PRIMARY TUMOR 440
REGIONAL LYMPH NODES 440
PROGNOSTIC GROUPS 440
SECTION 5:\rSalivary Glands 442
Chapter 141.\rMajor Salivary Glands 444
MACROSCOPIC ANATOMY 444
MICROSCOPIC ANATOMY 444
VARIATIONS 444
Congenital/Genetic/Hereditary 446
Chapter 142.\rPolycystic Disease of Parotid Gland 446
TERMINOLOGY 447
ETIOLOGY/PATHOGENESIS 447
CLINICAL ISSUES 447
IMAGING 447
MACROSCOPIC 447
MICROSCOPIC 447
ANCILLARY TESTS 447
DIFFERENTIAL DIAGNOSIS 447
SELECTED REFERENCES 447
Infectious 448
Chapter 143.\rHIV Salivary Gland Disease 448
TERMINOLOGY 449
ETIOLOGY/PATHOGENESIS 449
CLINICAL ISSUES 449
IMAGING 449
MICROSCOPIC 449
ANCILLARY TESTS 449
DIFFERENTIAL DIAGNOSIS 449
SELECTED REFERENCES 449
Inflammatory-Immune Dysfunction 450
Chapter 144.\rIgG4-Related Salivary Gland Disease 450
TERMINOLOGY 451
ETIOLOGY/PATHOGENESIS 451
CLINICAL ISSUES 451
MICROSCOPIC 451
ANCILLARY TESTS 451
DIFFERENTIAL DIAGNOSIS 452
SELECTED REFERENCES 452
Chapter 145.\rBenign Lymphoepithelial Cyst 454
TERMINOLOGY 455
ETIOLOGY/PATHOGENESIS 455
CLINICAL ISSUES 455
MACROSCOPIC 455
MICROSCOPIC 455
ANCILLARY TESTS 455
DIFFERENTIAL DIAGNOSIS 455
SELECTED REFERENCES 455
Chapter 146.\rBenign Lymphoepithelial Lesion 456
TERMINOLOGY 457
ETIOLOGY/PATHOGENESIS 457
CLINICAL ISSUES 457
MACROSCOPIC 457
MICROSCOPIC 457
ANCILLARY TESTS 457
DIFFERENTIAL DIAGNOSIS 457
SELECTED REFERENCES 457
Chapter 147.\rSjögren Syndrome 458
TERMINOLOGY 459
ETIOLOGY/PATHOGENESIS 459
CLINICAL ISSUES 459
IMAGING 459
MACROSCOPIC 459
MICROSCOPIC 459
ANCILLARY TESTS 460
DIFFERENTIAL DIAGNOSIS 460
SELECTED REFERENCES 460
Reactive 462
Chapter 148.\rOncocytosis (Oncocytic Hyperplasia) 462
Chapter 149.\rSialolithiasis 463
Chapter 150.\rSclerosing Polycystic Adenosis 464
TERMINOLOGY 465
CLINICAL ISSUES 465
MACROSCOPIC 465
MICROSCOPIC 465
ANCILLARY TESTS 465
DIFFERENTIAL DIAGNOSIS 465
SELECTED REFERENCES 465
Benign Neoplasm 466
Chapter 151.\rPleomorphic Adenoma 466
TERMINOLOGY 467
CLINICAL ISSUES 467
IMAGING 467
MACROSCOPIC 468
MICROSCOPIC 468
ANCILLARY TESTS 468
DIFFERENTIAL DIAGNOSIS 468
SELECTED REFERENCES 469
Chapter 152.\rMyoepithelioma 474
TERMINOLOGY 475
CLINICAL ISSUES 475
MACROSCOPIC 475
MICROSCOPIC 475
ANCILLARY TESTS 475
DIFFERENTIAL DIAGNOSIS 475
SELECTED REFERENCES 475
Chapter 153.\rBasal Cell Adenoma 476
TERMINOLOGY 477
CLINICAL ISSUES 477
MACROSCOPIC 477
MICROSCOPIC 477
ANCILLARY TESTS 477
DIFFERENTIAL DIAGNOSIS 477
SELECTED REFERENCES 477
Chapter 154.\rWarthin Tumor (Papillary Cystadenoma Lymphomatosum) 478
TERMINOLOGY 479
ETIOLOGY/PATHOGENESIS 479
CLINICAL ISSUES 479
IMAGING 479
MACROSCOPIC 479
MICROSCOPIC 479
ANCILLARY TESTS 480
DIFFERENTIAL DIAGNOSIS 480
SELECTED REFERENCES 480
Chapter 155.\rOncocytoma 482
TERMINOLOGY 483
ETIOLOGY/PATHOGENESIS 483
CLINICAL ISSUES 483
IMAGING 483
MACROSCOPIC 483
MICROSCOPIC 483
ANCILLARY TESTS 484
DIFFERENTIAL DIAGNOSIS 484
SELECTED REFERENCES 484
Chapter 156.\rCanalicular Adenoma 488
TERMINOLOGY 489
CLINICAL ISSUES 489
MACROSCOPIC 489
MICROSCOPIC 489
ANCILLARY TESTS 489
DIFFERENTIAL DIAGNOSIS 489
SELECTED REFERENCES 489
Chapter 157.\rLymphadenoma and Sebaceous Lymphadenoma 490
TERMINOLOGY 491
CLINICAL ISSUES 491
MACROSCOPIC 491
MICROSCOPIC 491
ANCILLARY TESTS 491
DIFFERENTIAL DIAGNOSIS 491
SELECTED REFERENCES 491
Chapter 158.\rSebaceous Adenoma 492
TERMINOLOGY 493
CLINICAL ISSUES 493
MACROSCOPIC 493
MICROSCOPIC 493
ANCILLARY TESTS 493
DIFFERENTIAL DIAGNOSIS 493
SELECTED REFERENCES 493
Chapter 159.\rDuctal Papillomas 494
TERMINOLOGY 495
CLINICAL ISSUES 495
MACROSCOPIC 495
MICROSCOPIC 495
ANCILLARY TESTS 496
DIFFERENTIAL DIAGNOSIS 496
SELECTED REFERENCES 496
Chapter 160.\rCystadenoma 498
TERMINOLOGY 499
CLINICAL ISSUES 499
MACROSCOPIC 499
MICROSCOPIC 499
DIFFERENTIAL DIAGNOSIS 499
SELECTED REFERENCES 499
Chapter 161.\rHemangioma 500
TERMINOLOGY 501
CLINICAL ISSUES 501
IMAGING 501
MACROSCOPIC 502
MICROSCOPIC 502
ANCILLARY TESTS 502
DIFFERENTIAL DIAGNOSIS 502
SELECTED REFERENCES 502
Borderline Neoplasm 504
Chapter 162.\rSialoblastoma 504
TERMINOLOGY 505
ETIOLOGY/PATHOGENESIS 505
CLINICAL ISSUES 505
IMAGING 505
MACROSCOPIC 505
MICROSCOPIC 505
ANCILLARY TESTS 505
DIFFERENTIAL DIAGNOSIS 506
SELECTED REFERENCES 506
Malignant Neoplasm 508
Chapter 163.\rMucoepidermoid Carcinoma 508
TERMINOLOGY 509
ETIOLOGY/PATHOGENESIS 509
CLINICAL ISSUES 509
IMAGING 510
MACROSCOPIC 510
MICROSCOPIC 510
ANCILLARY TESTS 510
DIFFERENTIAL DIAGNOSIS 510
SELECTED REFERENCES 511
Chapter 164.\rAdenoid Cystic Carcinoma 518
TERMINOLOGY 519
CLINICAL ISSUES 519
IMAGING 519
MACROSCOPIC 519
MICROSCOPIC 519
ANCILLARY TESTS 520
DIFFERENTIAL DIAGNOSIS 520
SELECTED REFERENCES 521
Chapter 165.\rAcinic Cell Carcinoma 526
TERMINOLOGY 527
ETIOLOGY/PATHOGENESIS 527
CLINICAL ISSUES 527
MACROSCOPIC 527
MICROSCOPIC 527
ANCILLARY TESTS 528
DIFFERENTIAL DIAGNOSIS 528
SELECTED REFERENCES 529
Chapter 166.\rMammary Analogue Secretory Carcinoma 534
TERMINOLOGY 535
ETIOLOGY/PATHOGENESIS 535
CLINICAL ISSUES 535
MACROSCOPIC 535
MICROSCOPIC 535
ANCILLARY TESTS 535
DIFFERENTIAL DIAGNOSIS 536
SELECTED REFERENCES 536
Chapter 167.\rPolymorphous Low-Grade Adenocarcinoma 538
TERMINOLOGY 539
ETIOLOGY/PATHOGENESIS 539
CLINICAL ISSUES 539
IMAGING 539
MACROSCOPIC 539
MICROSCOPIC 539
ANCILLARY TESTS 540
DIFFERENTIAL DIAGNOSIS 540
SELECTED REFERENCES 540
Chapter 168.\rCribriform Adenocarcinoma of Minor Salivary Glands 544
TERMINOLOGY 545
CLINICAL ISSUES 545
MACROSCOPIC 545
MICROSCOPIC 545
ANCILLARY TESTS 545
DIFFERENTIAL DIAGNOSIS 545
SELECTED REFERENCES 545
Chapter 169.\rCarcinoma Ex-Pleomorphic Adenoma 546
TERMINOLOGY 547
ETIOLOGY/PATHOGENESIS 547
CLINICAL ISSUES 547
IMAGING 548
MACROSCOPIC 548
MICROSCOPIC 548
ANCILLARY TESTS 549
DIFFERENTIAL DIAGNOSIS 549
REPORTING 550
SELECTED REFERENCES 550
Chapter 170.\rLow-Grade Intraductal Carcinoma 556
TERMINOLOGY 557
CLINICAL ISSUES 557
MACROSCOPIC 557
MICROSCOPIC 557
ANCILLARY TESTS 557
DIFFERENTIAL DIAGNOSIS 557
SELECTED REFERENCES 557
Chapter 171.\rSalivary Duct Carcinoma 558
TERMINOLOGY 559
ETIOLOGY/PATHOGENESIS 559
CLINICAL ISSUES 559
IMAGING 559
MACROSCOPIC 559
MICROSCOPIC 559
ANCILLARY TESTS 560
DIFFERENTIAL DIAGNOSIS 560
SELECTED REFERENCES 561
Chapter 172.\rEpithelial-Myoepithelial Carcinoma 566
TERMINOLOGY 567
CLINICAL ISSUES 567
MACROSCOPIC 567
MICROSCOPIC 567
ANCILLARY TESTS 567
DIFFERENTIAL DIAGNOSIS 568
SELECTED REFERENCES 568
Chapter 173.\rAdenocarcinoma, Not Otherwise Specified 572
TERMINOLOGY 573
CLINICAL ISSUES 573
MACROSCOPIC 573
MICROSCOPIC 573
DIFFERENTIAL DIAGNOSIS 573
GRADING 573
SELECTED REFERENCES 573
Chapter 174.\rClear Cell Carcinoma 574
TERMINOLOGY 575
ETIOLOGY/PATHOGENESIS 575
CLINICAL ISSUES 575
IMAGING 575
MACROSCOPIC 575
MICROSCOPIC 575
ANCILLARY TESTS 576
DIFFERENTIAL DIAGNOSIS 576
DIAGNOSTIC CHECKLIST 576
SELECTED REFERENCES 576
Chapter 175.\rCystadenocarcinoma 578
TERMINOLOGY 579
CLINICAL ISSUES 579
MACROSCOPIC 579
MICROSCOPIC 579
ANCILLARY TESTS 579
DIFFERENTIAL DIAGNOSIS 579
SELECTED REFERENCES 579
Chapter 176.\rMyoepithelial Carcinoma 582
TERMINOLOGY 583
ETIOLOGY/PATHOGENESIS 583
CLINICAL ISSUES 583
IMAGING 583
MACROSCOPIC 583
MICROSCOPIC 583
ANCILLARY TESTS 584
DIFFERENTIAL DIAGNOSIS 584
DIAGNOSTIC CHECKLIST 584
SELECTED REFERENCES 584
Chapter 177.\rSmall Cell Undifferentiated Carcinoma 586
TERMINOLOGY 587
ETIOLOGY/PATHOGENESIS 587
CLINICAL ISSUES 587
MACROSCOPIC 587
MICROSCOPIC 587
ANCILLARY TESTS 587
DIFFERENTIAL DIAGNOSIS 588
SELECTED REFERENCES 588
Chapter 178.\rLymphoepithelial Carcinoma 590
TERMINOLOGY 591
ETIOLOGY/PATHOGENESIS 591
CLINICAL ISSUES 591
MACROSCOPIC 591
MICROSCOPIC 591
ANCILLARY TESTS 592
DIFFERENTIAL DIAGNOSIS 592
SELECTED REFERENCES 592
Chapter 179.\rBasal Cell Adenocarcinoma 594
TERMINOLOGY 595
ETIOLOGY/PATHOGENESIS 595
CLINICAL ISSUES 595
MACROSCOPIC 595
MICROSCOPIC 595
ANCILLARY TESTS 596
DIFFERENTIAL DIAGNOSIS 596
SELECTED REFERENCES 596
Chapter 180.\rOncocytic Carcinoma 598
TERMINOLOGY 599
CLINICAL ISSUES 599
MACROSCOPIC 599
MICROSCOPIC 599
ANCILLARY TESTS 599
DIFFERENTIAL DIAGNOSIS 600
SELECTED REFERENCES 600
Chapter 181.\rSebaceous Carcinoma and Sebaceous Lymphadenocarcinoma 602
TERMINOLOGY 603
ETIOLOGY/PATHOGENESIS 603
CLINICAL ISSUES 603
MACROSCOPIC 603
MICROSCOPIC 603
ANCILLARY TESTS 603
DIFFERENTIAL DIAGNOSIS 603
SELECTED REFERENCES 603
Chapter 182.\rLymphoma 606
Chapter 183.\rMetastatic/Secondary Tumors 607
Specimen Examination, Salivary Glands 608
Chapter 184.\rSpecimen Examination and Staging Tools, Salivary Glands 608
PRIMARY TUMOR 608
REGIONAL LYMPH NODES 608
PROGNOSTIC GROUPS 608
SELECTED REFERENCES 608
SECTION 6: Jaw 610
Chapter 185.\rTeeth 612
MACROSCOPIC ANATOMY 612
MICROSCOPIC ANATOMY 612
PITFALLS/ARTIFACTS 612
AGE VARIATION 612
SELECTED REFERENCES 612
Congenital/Genetic/Hereditary 614
Chapter 186.\rCherubism 614
Reactive 615
Chapter 187.\rTori 615
Chapter 188.\rOsteomyelitis 616
TERMINOLOGY 617
ETIOLOGY/PATHOGENESIS 617
CLINICAL ISSUES 617
IMAGING 618
MACROSCOPIC 618
MICROSCOPIC 618
ANCILLARY TESTS 618
DIFFERENTIAL DIAGNOSIS 618
SELECTED REFERENCES 618
Chapter 189.\rFibrous Dysplasia 620
TERMINOLOGY 621
ETIOLOGY/PATHOGENESIS 621
CLINICAL ISSUES 621
IMAGING 621
MACROSCOPIC 622
MOLECULAR 622
MICROSCOPIC 622
ANCILLARY TESTS 622
DIFFERENTIAL DIAGNOSIS 622
SELECTED REFERENCES 622
Chapter 190.\rCemento-Osseous Dysplasia 624
TERMINOLOGY 625
ETIOLOGY/PATHOGENESIS 625
CLINICAL ISSUES 625
IMAGING 625
MACROSCOPIC 625
MICROSCOPIC 625
DIFFERENTIAL DIAGNOSIS 625
DIAGNOSTIC CHECKLIST 625
SELECTED REFERENCES 625
Chapter 191.\rOsteonecrosis 626
TERMINOLOGY 627
ETIOLOGY/PATHOGENESIS 627
CLINICAL ISSUES 627
IMAGING 628
MICROSCOPIC 628
DIFFERENTIAL DIAGNOSIS 628
SELECTED REFERENCES 628
Chapter 192.\rPaget Disease of Bone 630
TERMINOLOGY 631
ETIOLOGY/PATHOGENESIS 631
CLINICAL ISSUES 631
IMAGING 632
MACROSCOPIC 632
MICROSCOPIC 632
ANCILLARY TESTS 632
DIFFERENTIAL DIAGNOSIS 632
DIAGNOSTIC CHECKLIST 632
SELECTED REFERENCES 632
Cysts 634
Chapter 193.\rCentral Giant Cell Lesion 634
TERMINOLOGY 635
ETIOLOGY/PATHOGENESIS 635
CLINICAL ISSUES 635
IMAGING 635
MACROSCOPIC 635
MICROSCOPIC 635
ANCILLARY TESTS 635
DIFFERENTIAL DIAGNOSIS 635
SELECTED REFERENCES 635
Chapter 194.\rSimple Bone Cyst 636
TERMINOLOGY 637
ETIOLOGY/PATHOGENESIS 637
CLINICAL ISSUES 637
IMAGING 637
MACROSCOPIC 637
MICROSCOPIC 637
DIFFERENTIAL DIAGNOSIS 637
DIAGNOSTIC CHECKLIST 637
SELECTED REFERENCES 637
Chapter 195.\rDentigerous Cyst 638
TERMINOLOGY 639
ETIOLOGY/PATHOGENESIS 639
CLINICAL ISSUES 639
IMAGING 639
MACROSCOPIC 639
MICROSCOPIC 639
ANCILLARY TESTS 639
DIFFERENTIAL DIAGNOSIS 639
SELECTED REFERENCES 639
Chapter 196.\rGlandular Odontogenic Cyst 640
TERMINOLOGY 641
CLINICAL ISSUES 641
IMAGING 641
MICROSCOPIC 641
DIFFERENTIAL DIAGNOSIS 641
DIAGNOSTIC CHECKLIST 641
SELECTED REFERENCES 641
Chapter 197.\rCalcifying Odontogenic Cyst 642
TERMINOLOGY 643
CLINICAL ISSUES 643
IMAGING 643
MICROSCOPIC 643
DIFFERENTIAL DIAGNOSIS 643
SELECTED REFERENCES 643
Chapter 198.\rLateral Periodontal Cyst 644
TERMINOLOGY 645
ETIOLOGY/PATHOGENESIS 645
CLINICAL ISSUES 645
IMAGING 645
MACROSCOPIC 645
MICROSCOPIC 645
DIFFERENTIAL DIAGNOSIS 645
SELECTED REFERENCES 645
Chapter 199.\rPeriapical Cyst/Granuloma 646
TERMINOLOGY 647
CLINICAL ISSUES 647
IMAGING 647
MACROSCOPIC 647
MICROSCOPIC 647
DIFFERENTIAL DIAGNOSIS 647
SELECTED REFERENCES 647
Chapter 200.\rOdontogenic Keratocyst 648
TERMINOLOGY 649
ETIOLOGY/PATHOGENESIS 649
CLINICAL ISSUES 649
IMAGING 649
MICROSCOPIC 649
ANCILLARY TESTS 649
DIFFERENTIAL DIAGNOSIS 649
SELECTED REFERENCES 649
Benign Neoplasm 652
Chapter 201.\rAmeloblastoma 652
TERMINOLOGY 653
CLINICAL ISSUES 653
IMAGING 653
MACROSCOPIC 653
MICROSCOPIC 653
ANCILLARY TESTS 654
DIFFERENTIAL DIAGNOSIS 654
SELECTED REFERENCES 654
Chapter 202.\rSquamous Odontogenic Tumor 658
TERMINOLOGY 659
ETIOLOGY/PATHOGENESIS 659
CLINICAL ISSUES 659
IMAGING 659
MACROSCOPIC 659
MICROSCOPIC 659
DIFFERENTIAL DIAGNOSIS 659
SELECTED REFERENCES 659
Chapter 203.\rCalcifying Epithelial Odontogenic Tumor 660
TERMINOLOGY 661
CLINICAL ISSUES 661
IMAGING 661
MACROSCOPIC 661
MICROSCOPIC 661
ANCILLARY TESTS 661
DIFFERENTIAL DIAGNOSIS 661
SELECTED REFERENCES 661
Chapter 204.\rAdenomatoid Odontogenic Tumor 662
TERMINOLOGY 663
ETIOLOGY/PATHOGENESIS 663
CLINICAL ISSUES 663
IMAGING 663
MACROSCOPIC 663
MICROSCOPIC 663
DIFFERENTIAL DIAGNOSIS 663
DIAGNOSTIC CHECKLIST 663
SELECTED REFERENCES 663
Chapter 205.\rAmeloblastic Fibroma/Fibro-Odontoma 664
TERMINOLOGY 665
ETIOLOGY/PATHOGENESIS 665
CLINICAL ISSUES 665
IMAGING 665
MACROSCOPIC 665
MICROSCOPIC 665
ANCILLARY TESTS 665
DIFFERENTIAL DIAGNOSIS 665
DIAGNOSTIC CHECKLIST 665
SELECTED REFERENCES 665
Chapter 206.\rOdontoma (Complex and Compound) 666
TERMINOLOGY 667
ETIOLOGY/PATHOGENESIS 667
CLINICAL ISSUES 667
IMAGING 667
MACROSCOPIC 667
MICROSCOPIC 667
DIFFERENTIAL DIAGNOSIS 667
DIAGNOSTIC CHECKLIST 667
SELECTED REFERENCES 667
Chapter 207.\rOdontogenic Fibroma 668
TERMINOLOGY 669
ETIOLOGY/PATHOGENESIS 669
CLINICAL ISSUES 669
IMAGING 669
MACROSCOPIC 669
MICROSCOPIC 669
DIFFERENTIAL DIAGNOSIS 669
SELECTED REFERENCES 669
Chapter 208.\rCementoblastoma 670
TERMINOLOGY 671
CLINICAL ISSUES 671
IMAGING 671
MACROSCOPIC 671
MICROSCOPIC 671
DIFFERENTIAL DIAGNOSIS 671
DIAGNOSTIC CHECKLIST 671
SELECTED REFERENCES 671
Chapter 209.\rOssifying Fibroma 672
TERMINOLOGY 673
CLINICAL ISSUES 673
IMAGING 673
MACROSCOPIC 673
MICROSCOPIC 673
ANCILLARY TESTS 673
DIFFERENTIAL DIAGNOSIS 673
SELECTED REFERENCES 673
Chapter 210.\rJuvenile Active Ossifying Fibroma 674
TERMINOLOGY 675
CLINICAL ISSUES 675
IMAGING 675
MACROSCOPIC 675
MICROSCOPIC 675
ANCILLARY TESTS 675
DIFFERENTIAL DIAGNOSIS 675
SELECTED REFERENCES 675
Chapter 211.\rOsteoma 678
TERMINOLOGY 679
ETIOLOGY/PATHOGENESIS 679
CLINICAL ISSUES 679
IMAGING 679
MACROSCOPIC 679
MICROSCOPIC 679
DIFFERENTIAL DIAGNOSIS 679
SELECTED REFERENCES 679
Chapter 212.\rOsteoblastoma 680
TERMINOLOGY 681
CLINICAL ISSUES 681
IMAGING 681
MACROSCOPIC 681
MICROSCOPIC 681
ANCILLARY TESTS 681
DIFFERENTIAL DIAGNOSIS 681
SELECTED REFERENCES 681
Chapter 213.\rMelanotic Neuroectodermal Tumor of Infancy 682
TERMINOLOGY 683
ETIOLOGY/PATHOGENESIS 683
CLINICAL ISSUES 683
IMAGING 683
MACROSCOPIC 683
MICROSCOPIC 683
ANCILLARY TESTS 683
DIFFERENTIAL DIAGNOSIS 683
SELECTED REFERENCES 683
Malignant Neoplasm 684
Chapter 214.\rAmeloblastic Carcinoma 684
TERMINOLOGY 685
ETIOLOGY/PATHOGENESIS 685
CLINICAL ISSUES 685
IMAGING 685
MICROSCOPIC 685
ANCILLARY TESTS 685
DIFFERENTIAL DIAGNOSIS 685
SELECTED REFERENCES 685
Chapter 215.\rClear Cell Odontogenic Carcinoma 686
TERMINOLOGY 687
CLINICAL ISSUES 687
IMAGING 687
MACROSCOPIC 687
MICROSCOPIC 687
ANCILLARY TESTS 687
DIFFERENTIAL DIAGNOSIS 687
SELECTED REFERENCES 687
Chapter 216.\rAmeloblastic Fibrosarcoma 688
TERMINOLOGY 689
ETIOLOGY/PATHOGENESIS 689
CLINICAL ISSUES 689
IMAGING 689
MACROSCOPIC 689
MICROSCOPIC 689
ANCILLARY TESTS 689
DIFFERENTIAL DIAGNOSIS 689
SELECTED REFERENCES 689
Chapter 217.\rOsteosarcoma 690
TERMINOLOGY 691
ETIOLOGY/PATHOGENESIS 691
CLINICAL ISSUES 691
IMAGING 691
MACROSCOPIC 692
MICROSCOPIC 692
ANCILLARY TESTS 692
DIFFERENTIAL DIAGNOSIS 692
SELECTED REFERENCES 693
Chapter 218.\rChondrosarcoma 698
TERMINOLOGY 699
ETIOLOGY/PATHOGENESIS 699
CLINICAL ISSUES 699
IMAGING 699
MACROSCOPIC 699
MICROSCOPIC 699
ANCILLARY TESTS 700
DIFFERENTIAL DIAGNOSIS 700
GRADING 700
SELECTED REFERENCES 700
Chapter 219.\rFibrosarcoma 704
TERMINOLOGY 705
ETIOLOGY/PATHOGENESIS 705
CLINICAL ISSUES 705
IMAGING 705
MACROSCOPIC 705
MICROSCOPIC 705
ANCILLARY TESTS 705
DIFFERENTIAL DIAGNOSIS 705
GRADING 705
SELECTED REFERENCES 705
Chapter 220.\rPlasma Cell Myeloma 706
TERMINOLOGY 707
CLINICAL ISSUES 707
IMAGING 707
MICROSCOPIC 707
ANCILLARY TESTS 707
DIFFERENTIAL DIAGNOSIS 707
SELECTED REFERENCES 707
SECTION 7:\rEar and Temporal Bone 708
Chapter 221.\rEar 710
MACROSCOPIC ANATOMY 710
MICROSCOPIC ANATOMY 710
PITFALLS/ARTIFACTS 710
Congenital/Genetic/Hereditary 712
Chapter 222.\rAccessory Tragus 712
TERMINOLOGY 713
ETIOLOGY/PATHOGENESIS 713
CLINICAL ISSUES 713
MACROSCOPIC 713
MICROSCOPIC 713
DIFFERENTIAL DIAGNOSIS 713
DIAGNOSTIC CHECKLIST 713
SELECTED REFERENCES 713
Chapter 223.\rEncephalocele 714
TERMINOLOGY 715
ETIOLOGY/PATHOGENESIS 715
CLINICAL ISSUES 715
IMAGING 715
MICROSCOPIC 715
ANCILLARY TESTS 715
DIFFERENTIAL DIAGNOSIS 715
SELECTED REFERENCES 715
Chapter 224.\rFirst Branchial Cleft Anomaly 716
TERMINOLOGY 717
ETIOLOGY/PATHOGENESIS 717
CLINICAL ISSUES 717
IMAGING 717
MACROSCOPIC 717
MICROSCOPIC 718
ANCILLARY TESTS 718
DIFFERENTIAL DIAGNOSIS 718
STAGING 718
SELECTED REFERENCES 718
Infectious 720
Chapter 225.\rOtitis Media 720
TERMINOLOGY 721
ETIOLOGY/PATHOGENESIS 721
CLINICAL ISSUES 721
MICROSCOPIC 721
DIFFERENTIAL DIAGNOSIS 721
SELECTED REFERENCES 721
Chapter 226.\rNecrotizing Otitis Externa 722
TERMINOLOGY 723
ETIOLOGY/PATHOGENESIS 723
CLINICAL ISSUES 723
IMAGING 723
MICROSCOPIC 723
ANCILLARY TESTS 723
DIFFERENTIAL DIAGNOSIS 723
SELECTED REFERENCES 723
Inflammatory-Immune Dysfunction 724
Chapter 227.\rChondrodermatitis Nodularis Helicis 724
TERMINOLOGY 725
ETIOLOGY/PATHOGENESIS 725
CLINICAL ISSUES 725
MICROSCOPIC 725
DIFFERENTIAL DIAGNOSIS 725
SELECTED REFERENCES 725
Chapter 228.\rOtic Polyp 726
TERMINOLOGY 727
ETIOLOGY/PATHOGENESIS 727
CLINICAL ISSUES 727
IMAGING 727
MACROSCOPIC 727
MICROSCOPIC 727
ANCILLARY TESTS 727
DIFFERENTIAL DIAGNOSIS 727
SELECTED REFERENCES 727
Chapter 229.\rRelapsing Polychondritis 728
TERMINOLOGY 729
ETIOLOGY/PATHOGENESIS 729
CLINICAL ISSUES 729
MICROSCOPIC 729
ANCILLARY TESTS 729
DIFFERENTIAL DIAGNOSIS 729
SELECTED REFERENCES 729
Degenerative 730
Chapter 230.\rCystic Chondromalacia (Auricular Pseudocyst) 730
TERMINOLOGY 731
ETIOLOGY/PATHOGENESIS 731
CLINICAL ISSUES 731
MACROSCOPIC 731
MICROSCOPIC 731
DIFFERENTIAL DIAGNOSIS 731
SELECTED REFERENCES 731
Chapter 231.\rOtosclerosis 732
TERMINOLOGY 733
ETIOLOGY/PATHOGENESIS 733
CLINICAL ISSUES 733
IMAGING 733
MICROSCOPIC 733
ANCILLARY TESTS 733
DIFFERENTIAL DIAGNOSIS 733
SELECTED REFERENCES 733
Metabolic 734
Chapter 232.\rGout 734
TERMINOLOGY 735
ETIOLOGY/PATHOGENESIS 735
CLINICAL ISSUES 735
MACROSCOPIC 735
MICROSCOPIC 735
DIFFERENTIAL DIAGNOSIS 735
SELECTED REFERENCES 735
Reactive 736
Chapter 233.\rExostosis 736
TERMINOLOGY 737
ETIOLOGY/PATHOGENESIS 737
CLINICAL ISSUES 737
IMAGING 737
MACROSCOPIC 737
MICROSCOPIC 737
DIFFERENTIAL DIAGNOSIS 737
SELECTED REFERENCES 737
Chapter 234.\rKeloid 738
TERMINOLOGY 739
ETIOLOGY/PATHOGENESIS 739
CLINICAL ISSUES 739
MACROSCOPIC 739
MICROSCOPIC 739
DIFFERENTIAL DIAGNOSIS 739
DIAGNOSTIC CHECKLIST 739
SELECTED REFERENCES 739
Chapter 235.\rAngiolymphoid Hyperplasia With Eosinophilia 740
TERMINOLOGY 741
ETIOLOGY/PATHOGENESIS 741
CLINICAL ISSUES 741
MACROSCOPIC 741
MICROSCOPIC 741
ANCILLARY TESTS 741
DIFFERENTIAL DIAGNOSIS 741
SELECTED REFERENCES 741
Chapter 236.\rMalakoplakia 742
Chapter 237.\rSynovial Chondromatosis (Temporomandibular Joint) 743
Benign Neoplasm 744
Chapter 238.\rCeruminous Adenoma 744
TERMINOLOGY 745
CLINICAL ISSUES 745
MACROSCOPIC 745
MICROSCOPIC 745
ANCILLARY TESTS 745
DIFFERENTIAL DIAGNOSIS 745
SELECTED REFERENCES 745
Chapter 239.\rCholesteatoma 748
TERMINOLOGY 749
ETIOLOGY/PATHOGENESIS 749
CLINICAL ISSUES 749
IMAGING 749
MACROSCOPIC 750
MICROSCOPIC 750
ANCILLARY TESTS 750
DIFFERENTIAL DIAGNOSIS 750
SELECTED REFERENCES 750
Chapter 240.\rNeuroendocrine Adenoma of Middle Ear 752
TERMINOLOGY 753
CLINICAL ISSUES 753
IMAGING 753
MACROSCOPIC 753
MICROSCOPIC 753
ANCILLARY TESTS 753
DIFFERENTIAL DIAGNOSIS 754
DIAGNOSTIC CHECKLIST 754
SELECTED REFERENCES 754
Chapter 241.\rJugulotympanic Paraganglioma 758
TERMINOLOGY 759
ETIOLOGY/PATHOGENESIS 759
CLINICAL ISSUES 759
IMAGING 759
MACROSCOPIC 759
MICROSCOPIC 759
ANCILLARY TESTS 760
DIFFERENTIAL DIAGNOSIS 760
STAGING 760
SELECTED REFERENCES 760
Chapter 242.\rSchwannoma (Acoustic Neuroma) 764
TERMINOLOGY 765
ETIOLOGY/PATHOGENESIS 765
CLINICAL ISSUES 765
IMAGING 765
MACROSCOPIC 765
MICROSCOPIC 766
ANCILLARY TESTS 766
DIFFERENTIAL DIAGNOSIS 766
SELECTED REFERENCES 766
Chapter 243.\rMeningioma 768
TERMINOLOGY 769
CLINICAL ISSUES 769
IMAGING 769
MACROSCOPIC 769
MICROSCOPIC 769
ANCILLARY TESTS 769
DIFFERENTIAL DIAGNOSIS 769
SELECTED REFERENCES 769
Chapter 244.\rLangerhans Cell Histiocytosis 770
TERMINOLOGY 771
CLINICAL ISSUES 771
IMAGING 771
MICROSCOPIC 771
ANCILLARY TESTS 771
DIFFERENTIAL DIAGNOSIS 771
SELECTED REFERENCES 771
Malignant Neoplasm 772
Chapter 245. Atypical Fibroxanthoma 772
TERMINOLOGY 773
ETIOLOGY/PATHOGENESIS 773
CLINICAL ISSUES 773
MACROSCOPIC 773
MICROSCOPIC 773
ANCILLARY TESTS 773
DIFFERENTIAL DIAGNOSIS 773
SELECTED REFERENCES 773
Chapter 246.\rSquamous Cell Carcinoma 774
TERMINOLOGY 775
ETIOLOGY/PATHOGENESIS 775
CLINICAL ISSUES 775
MACROSCOPIC 775
MICROSCOPIC 775
ANCILLARY TESTS 776
DIFFERENTIAL DIAGNOSIS 776
DIAGNOSTIC CHECKLIST 776
SELECTED REFERENCES 776
Chapter 247.\rBasal Cell Carcinoma 778
TERMINOLOGY 779
ETIOLOGY/PATHOGENESIS 779
CLINICAL ISSUES 779
MACROSCOPIC 779
MICROSCOPIC 779
ANCILLARY TESTS 779
DIFFERENTIAL DIAGNOSIS 779
SELECTED REFERENCES 779
Chapter 248.\rMerkel Cell Carcinoma 780
TERMINOLOGY 781
ETIOLOGY/PATHOGENESIS 781
CLINICAL ISSUES 781
MACROSCOPIC 781
MICROSCOPIC 781
ANCILLARY TESTS 782
DIFFERENTIAL DIAGNOSIS 782
SELECTED REFERENCES 782
Chapter 249.\rDermatofibrosarcoma Protuberans 784
TERMINOLOGY 785
ETIOLOGY/PATHOGENESIS 785
CLINICAL ISSUES 785
IMAGING 785
MACROSCOPIC 785
MICROSCOPIC 785
ANCILLARY TESTS 785
DIFFERENTIAL DIAGNOSIS 786
SELECTED REFERENCES 786
Chapter 250.\rCeruminous Adenocarcinoma 788
TERMINOLOGY 789
CLINICAL ISSUES 789
IMAGING 789
MACROSCOPIC 789
MICROSCOPIC 789
ANCILLARY TESTS 789
DIFFERENTIAL DIAGNOSIS 789
SELECTED REFERENCES 789
Chapter 251.\rRhabdomyosarcoma 792
TERMINOLOGY 793
ETIOLOGY/PATHOGENESIS 793
CLINICAL ISSUES 793
IMAGING 793
MACROSCOPIC 793
MICROSCOPIC 793
ANCILLARY TESTS 794
DIFFERENTIAL DIAGNOSIS 794
SELECTED REFERENCES 794
Chapter 252. \rMetastatic/Secondary Tumors 798
TERMINOLOGY 799
CLINICAL ISSUES 799
MACROSCOPIC 799
MICROSCOPIC 799
ANCILLARY TESTS 799
DIFFERENTIAL DIAGNOSIS 799
SELECTED REFERENCES 799
Chapter 253.\rEndolymphatic Sac Tumor 800
TERMINOLOGY 801
ETIOLOGY/PATHOGENESIS 801
CLINICAL ISSUES 801
IMAGING 801
MACROSCOPIC 801
MICROSCOPIC 801
ANCILLARY TESTS 802
DIFFERENTIAL DIAGNOSIS 802
SELECTED REFERENCES 802
SECTION 8: Neck (Soft Tissue and Lymph Nodes) 805
Chapter 254.\rLymph Nodes 806
MACROSCOPIC ANATOMY 806
MICROSCOPIC ANATOMY 806
Congenital/Genetic/Hereditary 808
Chapter 255.\rBranchial Cleft Cyst 808
TERMINOLOGY 809
ETIOLOGY/PATHOGENESIS 809
CLINICAL ISSUES 809
IMAGING 810
MACROSCOPIC 810
MICROSCOPIC 810
ANCILLARY TESTS 810
DIFFERENTIAL DIAGNOSIS 810
SELECTED REFERENCES 811
Chapter 256.\rCervical Thymic Cyst 814
TERMINOLOGY 815
ETIOLOGY/PATHOGENESIS 815
CLINICAL ISSUES 815
IMAGING 815
MACROSCOPIC 815
MICROSCOPIC 815
DIFFERENTIAL DIAGNOSIS 815
SELECTED REFERENCES 815
Chapter 257. Bronchogenic Cyst 816
TERMINOLOGY 817
ETIOLOGY/PATHOGENESIS 817
CLINICAL ISSUES 817
IMAGING 817
MACROSCOPIC 817
MICROSCOPIC 817
ANCILLARY TESTS 817
DIFFERENTIAL DIAGNOSIS 817
SELECTED REFERENCES 817
Infectious 818
Chapter 258.\rCat Scratch Disease 818
TERMINOLOGY 819
ETIOLOGY/PATHOGENESIS 819
CLINICAL ISSUES 819
IMAGING 819
MACROSCOPIC 819
MICROSCOPIC 820
ANCILLARY TESTS 820
DIFFERENTIAL DIAGNOSIS 820
SELECTED REFERENCES 820
Chapter 259.\rBacillary Angiomatosis 822
TERMINOLOGY 823
ETIOLOGY/PATHOGENESIS 823
CLINICAL ISSUES 823
MICROSCOPIC 823
ANCILLARY TESTS 823
DIFFERENTIAL DIAGNOSIS 823
SELECTED REFERENCES 823
Chapter 260.\rMycobacterial Spindle Cell Pseudotumor 824
TERMINOLOGY 825
ETIOLOGY/PATHOGENESIS 825
CLINICAL ISSUES 825
MICROSCOPIC 825
ANCILLARY TESTS 825
DIFFERENTIAL DIAGNOSIS 825
SELECTED REFERENCES 825
Inflammatory-Immune Dysfunction 826
Chapter 261.\rSarcoidosis 826
TERMINOLOGY 827
ETIOLOGY/PATHOGENESIS 827
CLINICAL ISSUES 827
MICROSCOPIC 827
ANCILLARY TESTS 827
DIFFERENTIAL DIAGNOSIS 827
SELECTED REFERENCES 827
Reactive 828
Chapter 262.\rNodular Fasciitis 828
TERMINOLOGY 829
ETIOLOGY/PATHOGENESIS 829
CLINICAL ISSUES 829
MACROSCOPIC 829
MICROSCOPIC 829
ANCILLARY TESTS 829
DIFFERENTIAL DIAGNOSIS 829
SELECTED REFERENCES 829
Benign Neoplasm 830
Chapter 263.\rCarotid Body Paraganglioma 830
TERMINOLOGY 831
ETIOLOGY/PATHOGENESIS 831
CLINICAL ISSUES 831
IMAGING 832
MACROSCOPIC 832
MICROSCOPIC 832
ANCILLARY TESTS 832
DIFFERENTIAL DIAGNOSIS 832
SELECTED REFERENCES 832
Chapter 264.\rElastofibroma 836
TERMINOLOGY 837
ETIOLOGY/PATHOGENESIS 837
CLINICAL ISSUES 837
IMAGING 837
MACROSCOPIC 837
MICROSCOPIC 837
DIFFERENTIAL DIAGNOSIS 837
SELECTED REFERENCES 837
Chapter 265.\rPerineurioma 838
TERMINOLOGY 839
ETIOLOGY/PATHOGENESIS 839
CLINICAL ISSUES 839
MACROSCOPIC 839
MICROSCOPIC 839
ANCILLARY TESTS 839
DIFFERENTIAL DIAGNOSIS 840
SELECTED REFERENCES 840
Chapter 266.\rLipoma 842
TERMINOLOGY 843
CLINICAL ISSUES 843
IMAGING 843
MACROSCOPIC 843
MICROSCOPIC 843
ANCILLARY TESTS 843
DIFFERENTIAL DIAGNOSIS 843
SELECTED REFERENCES 843
Chapter 267.\rSpindle Cell Lipoma 844
TERMINOLOGY 845
CLINICAL ISSUES 845
MACROSCOPIC 845
MICROSCOPIC 845
ANCILLARY TESTS 845
DIFFERENTIAL DIAGNOSIS 845
SELECTED REFERENCES 845
Chapter 268.\rLipoblastoma 846
TERMINOLOGY 847
CLINICAL ISSUES 847
IMAGING 847
MACROSCOPIC 847
MICROSCOPIC 847
ANCILLARY TESTS 847
DIFFERENTIAL DIAGNOSIS 847
SELECTED REFERENCES 847
Chapter 269.\rNuchal-Type Fibroma 848
TERMINOLOGY 849
ETIOLOGY/PATHOGENESIS 849
CLINICAL ISSUES 849
MACROSCOPIC 849
MICROSCOPIC 849
ANCILLARY TESTS 849
DIFFERENTIAL DIAGNOSIS 849
DIAGNOSTIC CHECKLIST 849
SELECTED REFERENCES 849
Chapter 270.\rHibernoma 850
TERMINOLOGY 851
CLINICAL ISSUES 851
IMAGING 851
MACROSCOPIC 851
MICROSCOPIC 851
ANCILLARY TESTS 851
DIFFERENTIAL DIAGNOSIS 851
SELECTED REFERENCES 851
Chapter 271.\rLymphangioma 852
TERMINOLOGY 853
ETIOLOGY/PATHOGENESIS 853
CLINICAL ISSUES 853
IMAGING 853
MACROSCOPIC 853
MICROSCOPIC 853
ANCILLARY TESTS 853
DIFFERENTIAL DIAGNOSIS 853
SELECTED REFERENCES 853
Malignant Neoplasm 854
Chapter 272. Metastatic Cystic Squamous Cell Carcinoma 854
TERMINOLOGY 855
ETIOLOGY/PATHOGENESIS 855
CLINICAL ISSUES 855
IMAGING 856
MACROSCOPIC 856
MICROSCOPIC 856
ANCILLARY TESTS 857
DIFFERENTIAL DIAGNOSIS 857
SELECTED REFERENCES 857
Chapter 273.\rSynovial Sarcoma 860
TERMINOLOGY 861
CLINICAL ISSUES 861
IMAGING 861
MACROSCOPIC 861
MICROSCOPIC 861
ANCILLARY TESTS 861
DIFFERENTIAL DIAGNOSIS 862
SELECTED REFERENCES 862
Chapter 274.\rChordoma 866
TERMINOLOGY 867
ETIOLOGY/PATHOGENESIS 867
CLINICAL ISSUES 867
IMAGING 868
MACROSCOPIC 868
MICROSCOPIC 868
ANCILLARY TESTS 868
DIFFERENTIAL DIAGNOSIS 869
SELECTED REFERENCES 869
Chapter 275.\rLiposarcoma 872
TERMINOLOGY 873
ETIOLOGY/PATHOGENESIS 873
CLINICAL ISSUES 873
MACROSCOPIC 873
MICROSCOPIC 873
ANCILLARY TESTS 875
DIFFERENTIAL DIAGNOSIS 876
SELECTED REFERENCES 876
SECTION 9:\rThyroid Gland 880
Chapter 276.\rThyroid 882
MACROSCOPIC 882
MICROSCOPIC 882
Congenital/Genetic/Hereditary 884
Chapter 277.\rThyroglossal Duct Cyst 884
TERMINOLOGY 885
ETIOLOGY/PATHOGENESIS 885
CLINICAL ISSUES 885
IMAGING 885
MACROSCOPIC 885
MICROSCOPIC 885
ANCILLARY TESTS 886
DIFFERENTIAL DIAGNOSIS 886
SELECTED REFERENCES 886
Chapter 278.\rEctopic Thyroid 888
TERMINOLOGY 889
ETIOLOGY/PATHOGENESIS 889
CLINICAL ISSUES 889
MICROSCOPIC 889
ANCILLARY TESTS 890
DIFFERENTIAL DIAGNOSIS 890
SELECTED REFERENCES 890
Chapter 279.\rSolid Cell Nests 892
TERMINOLOGY 893
ETIOLOGY/PATHOGENESIS 893
CLINICAL ISSUES 893
MACROSCOPIC 893
MICROSCOPIC 893
ANCILLARY TESTS 893
DIFFERENTIAL DIAGNOSIS 893
SELECTED REFERENCES 893
Chapter 280.\rDyshormonogenetic Goiter 894
TERMINOLOGY 895
ETIOLOGY/PATHOGENESIS 895
CLINICAL ISSUES 895
MACROSCOPIC 895
MICROSCOPIC 895
ANCILLARY TESTS 896
DIFFERENTIAL DIAGNOSIS 896
DIAGNOSTIC CHECKLIST 896
SELECTED REFERENCES 896
Infectious 898
Chapter 281.\rInfectious Thyroiditis 898
TERMINOLOGY 899
ETIOLOGY/PATHOGENESIS 899
CLINICAL ISSUES 899
MACROSCOPIC 899
MICROSCOPIC 900
ANCILLARY TESTS 900
DIFFERENTIAL DIAGNOSIS 900
SELECTED REFERENCES 900
Inflammatory-Immune Dysfunction 902
Chapter 282.\rPalpation Thyroiditis 902
TERMINOLOGY 903
ETIOLOGY/PATHOGENESIS 903
CLINICAL ISSUES 903
MACROSCOPIC 903
MICROSCOPIC 903
DIFFERENTIAL DIAGNOSIS 903
SELECTED REFERENCES 903
Chapter 283.\rSubacute Granulomatous Thyroiditis (de Quervain) 904
TERMINOLOGY 905
ETIOLOGY/PATHOGENESIS 905
CLINICAL ISSUES 905
IMAGING 906
MACROSCOPIC 906
MICROSCOPIC 906
ANCILLARY TESTS 906
DIFFERENTIAL DIAGNOSIS 906
SELECTED REFERENCES 906
Chapter 284.\rChronic Lymphocytic (Hashimoto) Thyroiditis 908
TERMINOLOGY 909
ETIOLOGY/PATHOGENESIS 909
CLINICAL ISSUES 909
IMAGING 910
MACROSCOPIC 910
MICROSCOPIC 910
ANCILLARY TESTS 911
DIFFERENTIAL DIAGNOSIS 911
SELECTED REFERENCES 911
Chapter 285.\rGraves Disease (Diffuse Hyperplasia) 914
TERMINOLOGY 915
ETIOLOGY/PATHOGENESIS 915
CLINICAL ISSUES 915
IMAGING 916
MACROSCOPIC 916
MICROSCOPIC 916
ANCILLARY TESTS 917
DIFFERENTIAL DIAGNOSIS 917
SELECTED REFERENCES 917
Chapter 286.\rRiedel Thyroiditis 920
TERMINOLOGY 921
ETIOLOGY/PATHOGENESIS 921
CLINICAL ISSUES 921
MACROSCOPIC 921
MICROSCOPIC 921
ANCILLARY TESTS 922
DIFFERENTIAL DIAGNOSIS 922
SELECTED REFERENCES 922
Reactive 924
Chapter 287.\rAdenomatoid Nodule 924
TERMINOLOGY 925
ETIOLOGY/PATHOGENESIS 925
CLINICAL ISSUES 925
IMAGING 926
MACROSCOPIC 926
MICROSCOPIC 926
ANCILLARY TESTS 927
DIFFERENTIAL DIAGNOSIS 927
SELECTED REFERENCES 927
Chapter 288.\rAmyloid Goiter 932
TERMINOLOGY 933
ETIOLOGY/PATHOGENESIS 933
CLINICAL ISSUES 933
MACROSCOPIC 933
MICROSCOPIC 934
ANCILLARY TESTS 934
DIFFERENTIAL DIAGNOSIS 934
SELECTED REFERENCES 934
Chapter 289.\rPigments and Crystals in Thyroid Gland 936
TERMINOLOGY 937
ETIOLOGY/PATHOGENESIS 937
CLINICAL ISSUES 937
MICROSCOPIC 937
ANCILLARY TESTS 938
DIFFERENTIAL DIAGNOSIS 938
SELECTED REFERENCES 938
Chapter 290.\rPost Fine-Needle Aspiration Changes 940
SECTION 10:\rParathyroid Glands 1097
Chapter 320.\rParathyroid 1098
MACROSCOPIC 1098
MICROSCOPIC 1098
PITFALLS/ARTIFACTS 1098
Nonneoplastic 1100
Chapter 321.\rParathyroid Hyperplasia 1100
TERMINOLOGY 1101
ETIOLOGY/PATHOGENESIS 1101
CLINICAL ISSUES 1101
IMAGING 1102
MACROSCOPIC 1102
MICROSCOPIC 1103
ANCILLARY TESTS 1103
DIFFERENTIAL DIAGNOSIS 1104
SELECTED REFERENCES 1104
Chapter 322.\rChronic Parathyroiditis 1106
Chapter 323.\rTertiary Hyperparathyroidism 1107
Benign Neoplasm 1108
Chapter 324.\rParathyroid Adenoma 1108
TERMINOLOGY 1109
ETIOLOGY/PATHOGENESIS 1109
CLINICAL ISSUES 1109
IMAGING 1110
MACROSCOPIC 1110
MICROSCOPIC 1110
ANCILLARY TESTS 1111
DIFFERENTIAL DIAGNOSIS 1111
SELECTED REFERENCES 1111
Malignant Neoplasm 1114
Chapter 325.\rParathyroid Carcinoma 1114
TERMINOLOGY 1115
ETIOLOGY/PATHOGENESIS 1115
CLINICAL ISSUES 1115
IMAGING 1115
MACROSCOPIC 1116
MICROSCOPIC 1116
ANCILLARY TESTS 1116
DIFFERENTIAL DIAGNOSIS 1116
SELECTED REFERENCES 1117
Chapter 326.\rMetastatic/Secondary Tumors 1120
TERMINOLOGY 1121
ETIOLOGY/PATHOGENESIS 1121
CLINICAL ISSUES 1121
MACROSCOPIC 1121
MICROSCOPIC 1121
ANCILLARY TESTS 1121
DIFFERENTIAL DIAGNOSIS 1121
SELECTED REFERENCES 1121
INDEX I-i