Menu Expand
Essentials of Internal Medicine 3e

Essentials of Internal Medicine 3e

Nicholas J Talley | Brad Frankum | David Currow

(2015)

Additional Information

Book Details

Abstract

Building on established diagnostic techniques, Essentials of Internal Medicine 3e presents a modern approach to internal medicine, equipping the reader with the skills to become an effective internist.

This text presents practical approaches to diagnosis and up to date strategies for implementing evidence-based treatments for prevalent conditions.

Learn how to:

  • Identify what is clinically important
  • Understand and investigate disease
  • Create an effective strategy for treatment
  • Utilize technological diagnostic tools now available
  • Color illustrations to enhance recognition and learning
  • Clinical pearls
  • Memory jog lists and tables
  • Multiple choice questions with answers and explanations

Content has been organized around themes of:

  • Holistic approach to patient treatment
  • The importance of diagnosis
  • The physician’s role in public health
  • The physician as scholar

Table of Contents

Section Title Page Action Price
Front Cover Cover
Essentials of Internal Medicine iii
Copyright Page iv
Table of Contents vii
FOREWORD BY KENNETH DEVAULT v
FOREWORD BY NICHOLAS SAUNDERS vi
PREFACE xxi
CONTRIBUTORS xxii
REVIEWERS xxiv
CHAPTER 1. INTERNAL MEDICINE IN THE 21st CENTURY—BEST PRACTICE, BEST OUTCOMES 1
GENERAL VERSUS SUB-SPECIALTY MEDICINE 1
THE IMPORTANCE OF DIAGNOSIS 2
THE PHYSICIAN’S ROLE IN PUBLIC HEALTH 2
THE PHYSICIAN AS SCHOLAR 2
CHAPTER 2. EVIDENCE-BASED MEDICINE AND CRITICAL APPRAISAL OF THE LITERATURE 5
INTRODUCTION 5
ASSESSING THE EVIDENCE 5
CRITICAL APPRAISAL OF THE LITERATURE 8
INTERPRETING A STUDY’S FINDINGS 9
INTERPRETING STATISTICAL ANALYSIS 10
INTERPRETING TEST RESULTS 11
SCREENING 13
CONCLUSION 13
ACKNOWLEDGMENTS 13
SELF-ASSESSMENT QUESTIONS 14
CHAPTER 3. ETHICS 17
ETHICS IN INTERNAL MEDICINE 17
ETHICAL THEORIES 18
ETHICS AND THE LAW 18
ETHICS, EVIDENCE AND DECISION-MAKING 18
CLINICAL ETHICS: THEORY AND FRAMEWORKS FOR DECISION-MAKING 19
TEACHING ABOUT ETHICS 19
PHYSICIAN–PATIENT RELATIONSHIPS AND PROFESSIONALISM 19
TRUTH-TELLING 19
CONFIDENTIALITY 20
CONSENT 21
MENTAL COMPETENCE 21
END-OF-LIFE AND FUTILITY 22
DIGNITY AND THE CARE OF THE ELDERLY 22
CONFLICT OF INTEREST AND THE PHARMACEUTICAL INDUSTRY 23
References 23
SELF-ASSESSMENT QUESTIONS 24
CHAPTER 4. CLINICAL PHARMACOLOGY AND TOXICOLOGY 27
1. PRINCIPLES OF CLINICAL PHARMACOLOGY 28
INTRODUCTION 28
PHARMACOKINETICS 29
PHARMACODYNAMICS 34
THE INNOCENT BYSTANDER 36
2. QUALITY USE OF MEDICINES 36
GETTING IT RIGHT 37
PRESCRIBING 37
DEPRESCRIBING 38
ADVERSE DRUG REACTIONS 38
DRUG INTERACTIONS 39
THERAPEUTIC DRUG MONITORING (TDM) 40
DRUG REGULATION 40
DRUG RESEARCH 41
3. TOXICOLOGY 42
EPIDEMIOLOGY OF POISONING 42
SOURCES OF POISONS INFORMATION AND ADVICE 42
CLINICAL ASSESSMENT OF POISONED PATIENTS 42
PRINCIPLES OF MANAGEMENT OF POISONED PATIENTS 43
COMMON POISONS AND THEIR MANAGEMENT 44
DRUGS OF ABUSE OR MISUSE 47
CHEMICALS 49
SPIDER BITES 49
SNAKE BITES 50
MARINE ENVENOMATION 50
TERRORISM, AND USE OF MEDICAL COUNTERMEASURES 51
SELF-ASSESSMENT QUESTIONS 53
CHAPTER 5. GENETICS 57
OVERVIEW 57
THE FLOW OF GENETICINFORMATION 58
GENETIC VARIATION 61
MENDELIAN DISEASES 62
CALCULATING THE RISKSOF DISEASE 63
GENETIC TESTING INMEDICINE 64
COMMON CHROMOSOMAL GENETIC CONDITIONS 65
ACKNOWLEDGMENTS 66
SELF-ASSESSMENT QUESTIONS 67
CHAPTER 6. MEDICAL IMAGING FOR INTERNISTS 71
1. CHEST RADIOGRAPHY 72
PRINCIPLES OFINTERPRETATION IN CHEST X-RAYS 72
2. THORACIC COMPUTEDTOMOGRAPHY 80
TECHNIQUES OF EXAMINATION 80
PRINCIPLES OF INTERPRETATION IN CHEST CT 80
3. ABDOMINAL COMPUTED TOMOGRAPHY 85
TECHNIQUES OF EXAMINA 85
PRINCIPLES OF INTERPRETATION IN ABDOMINAL CT 86
4. ABDOMINAL ULTRASOUND 90
BACKGROUND—ULTRASOUND PRINCIPLES 90
PRINCIPLES OF ULTRASOUND INTERPRETATION 91
LOWER LIMB DUPLEX ULTRASOUND 93
5. HEAD COMPUTED TOMOGRAPHY 94
CT BRAIN PROTOCOLS 94
PRINCIPLES OF INTERPRETATION IN BRAIN CT 95
6. HEAD MAGNETIC RESONANCE 101
MRI PROTOCOLS 102
PRINCIPLES OF INTERPRETATION IN BRAIN MR 107
7. POSITRON EMISSION TOMOGRAPHY (PET) 111
CHAPTER 7. PULMONOLOGY 113
1. PULMONARY MEDICINE 114
CLINICAL PRESENTATIONS OF RESPIRATORY DISEASE 114
IMPORTANT CLINICAL CLUES 114
OVERVIEW OF THE RESPIRATORY SYSTEM AND PATHOPHYSIOLOGY 118
ACID–BASE DISTURBANCES FROM A PULMONARY PERSPECTIVE 120
MEASUREMENT OF LUNG FUNCTION 120
CONTROL OF BREATHING 122
RESPIRATORY TRACT DEFENSES 122
GENETICS OF LUNG DISEASE 124
PULMONARY DISORDERS 124
DISEASES OF THE AIRWAYS 124
EOSINOPHILIC PULMONARY DISORDERS 133
PULMONARY HEMORRHAGE 133
PULMONARY INFECTIONS 134
PLEURAL DISEASE 136
PNEUMOTHORAX 138
PULMONARY VASCULAR DISEASE 138
LUNG TRANSPLANTATION 140
PHARMACOLOGY 141
RESPIRATORY SLEEP MEDICINE 142
2. CRITICAL CARE MEDICINE 144
RESUSCITATION 144
DIAGNOSIS AND DISEASE MANAGEMENT 144
MECHANICAL VENTILATION OF THE LUNGS 147
SELF-ASSESSMENT QUESTIONS 150
CHAPTER 8. CARDIOLOGY 153
CLINICAL EVALUATION OF THE PATIENT 154
INVESTIGATION OF CARDIAC DISEASE 160
DYSLIPIDEMIA 168
CORONARY ARTERY DISEASE (CAD) 172
STABLE CORONARY ARTERY DISEASE 172
ACUTE CORONARY SYNDROMES 177
VALVULAR HEART DISEASE 181
MITRAL VALVE DISEASE 182
AORTIC VALVE DISEASE 185
TRICUSPID VALVE DISEASE 188
PULMONARY VALVE DISEASE 189
CARDIOMYOPATHIES 190
CARDIAC ARRHYTHMIAS 194
CONDUCTION DEFECTS 201
CARDIAC FAILURE 203
INFECTIVE ENDOCARDITIS 208
PERICARDIAL DISEASES 211
SELF-ASSESSMENT QUESTIONS 214
CHAPTER 9. HYPERTENSION 217
MECHANISMS OF HYPERTENSION 217
EPIDEMIOLOGICAL EVIDENCE FOR HYPERTENSION AND ITS EFFECTS 218
DEFINITIONS OF HYPERTENSION 220
CLINICAL PRESENTATIONS AND INVESTIGATIONS 221
TARGET-ORGAN EFFECTS OF HYPERTENSION 222
TREATMENT AND TARGETS FOR HYPERTENSION CONTROL 224
TREATMENT FOR CHRONIC PRIMARY HYPERTENSION 225
TREATMENT IN AN ACUTE SETTING 226
SELF-ASSESSMENT QUESTIONS 228
CHAPTER 10. NEPHROLOGY 231
INHERITED CYSTIC KIDNEY DISEASE 232
ACQUIRED KIDNEY CYSTIC DISEASE 234
KIDNEY AND URINARY TRACT INFECTION 238
INHERITED RENAL BASEMENT MEMBRANE DISEASE 238
GLOMERULONEPHRITIS (GN) 239
SCLEROSING GLOMERULAR DISEASE 248
VASCULAR RENAL DISEASE 251
THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)/HEMOLYTIC UREMIC SYNDROME (HUS) 251
MALIGNANT HYPERTENSION 252
SCLERODERMA KIDNEY 252
REFLUX NEPHROPATHY 253
CHRONIC KIDNEY DISEASE (CKD) 253
ACUTE RENAL FAILURE—ACUTE KIDNEY INJURY (AKI) 257
TUBULO-INTERSTITIAL DISEASES 257
ELECTROLYTE DISORDERS 258
INHERITED ‘CHANNELOPATHIES’ ASSOCIATED WITH HYPERTENSION OR HYPERKALEMIA 261
THE KIDNEYS IN PREGNANCY AND PREGNANCY-RELATED DISEASES 262
SELF-ASSESSMENT QUESTIONS 264
CHAPTER 11. ENDOCRINOLOGY 267
SYSTEM OVERVIEW 268
DISORDERS OF THE PITUITARY AND HYPOTHALAMUS 270
THYROID DISORDERS 275
DISORDERS OF BONE AND MINERAL METABOLISM 281
ADRENAL DISORDERS 287
GROWTH AND PUBERTY 294
MALE REPRODUCTIVE ENDOCRINOLOGY 295
FEMALE REPRODUCTIVE ENDOCRINOLOGY 298
NEUROENDOCRINE TUMORS (NETs) 300
DISORDERS OF MULTIPLE ENDOCRINE SYSTEMS 302
DIABETES AND METABOLISM 303
SELF-ASSESSMENT QUESTIONS 315
CHAPTER 12. GASTROENTEROLOGY 319
ESOPHAGUS 320
STOMACH 323
SMALL BOWEL 327
NUTRITIONAL DEFICIENCY 338
LARGE BOWEL 342
BOWEL CANCER SCREENING 353
GASTROINTESTINAL BLEEDING 355
PANCREAS 358
SELF-ASSESSMENT QUESTIONS 364
CHAPTER 13. HEPATOLOGY 371
LIVER FUNCTION TESTS AND THEIR ABNORMALITIES 372
APPROACH TO THE PATIENT WITH LIVER DISEASE 372
BILIRUBIN METABOLISM AND JAUNDICE 374
VIRAL HEPATITIS 377
CIRRHOSIS 383
ASCITES 385
HEPATORENAL SYNDROME (HRS) 387
HYPONATREMIA 387
SPONTANEOUS BACTERIAL PERITONITIS (SBP) 388
PORTAL HYPERTENSIVE BLEEDING 388
PORTOSYSTEMIC ENCEPHALOPATHY (PSE) 389
PORTOPULMONARY HYPERTENSION (POPH) 391
HEPATOPULMONARY SYNDROME (HPS) 391
CIRRHOTIC CARDIOMYOPATHY 392
ACUTE LIVER FAILURE (ALF) 392
LIVER TRANSPLANTATION 393
DRUGS AND THE LIVER 394
ALCOHOL AND THE LIVER 394
SPECIFIC LIVER DISEASES 396
AUTOIMMUNE LIVER DISEASES 398
SYSTEMIC DISEASE AND THE LIVER 400
PREGNANCY AND LIVER DISEASE 400
GALLBLADDER AND BILIARY TREE 400
PORPHYRIAS 401
SELF-ASSESSMENT QUESTIONS 402
CHAPTER 14. HEMATOLOGY 407
HEMOSTASIS 408
VENOUS THROMBOSIS 410
ANTIPHOSPHOLIPID SYNDROME (APS) 412
THROMBOSIS AT UNUSUALSITES 413
CANCER AND THROMBOSIS 413
BLEEDING DISORDERS 414
PLATELET DISORDERS 417
DISSEMINATED INTRAVASCULAR COAGULATION (DIC) 419
COAGULOPATHY IN INTENSIVE CARE PATIENTS 421
MYELOPROLIFERATIVE DISORDERS 421
LEUKEMIA 426
NON- HODGKIN LYMPHOMAS 434
HODGKIN LYMPHOMA (HL) 436
PLASMA CELL DISORDERS 438
ANEMIA 440
SELF- ASSESSMENT QUESTIONS 451
CHAPTER 15. ONCOLOGY 455
WHAT IS CANCER? 457
PREVENTION 457
DIAGNOSIS 458
PROGNOSIS 459
TREATMENT PRINCIPLES 459
PRINCIPLES OF CHEMOTHERAPY 460
PRINCIPLES OF RADIOTHERAPY 461
TREATMENT RESPONSIVENESS 462
PERSONALIZED MEDICINE 462
MOLECULAR TARGETED THERAPY 462
FAMILIAL CANCERS AND CANCER GENETICS 463
ONCOLOGICAL EMERGENCIES 463
TUMOR MARKERS IN SERUM 465
PARANEOPLASTIC SYNDROME 466
CANCER WITH UNKNOWN PRIMARY (CUP) 466
LUNG CANCER 467
RENAL CANCER 469
TUMORS OF THE PELVIS, URETER AND BLADDER 469
PROSTATE CANCER 470
TESTIS CANCER 471
HEAD AND NECK CANCER 473
ESOPHAGEAL CANCER 473
GASTRIC CANCER 474
COLORECTAL CANCER 475
PANCREATIC CANCER 477
HEPATOCELLULAR CARCINOMA (HCC) 478
BRAIN TUMORS 479
LYMPHOMA 480
MELANOMA 480
SARCOMA 481
BREAST CANCER 482
OVARIAN CANCER 484
ENDOMETRIAL CANCER 486
SELF- ASSESSMENT QUESTIONS 487
CHAPTER 16. PALLIATIVE MEDICINE 489
PAIN 490
MUCOSITIS 492
FATIGUE 493
NAUSEA AND VOMITING 493
CACHEXIA AND ANOREXIA 496
DYSPNEA 497
CONSTIPATION 498
DELIRIUM 498
INSOMNIA 499
SELF-ASSESSMENT QUESTIONS 501
CHAPTER 17. IMMUNOLOGY 503
KEY CONCEPTS IN IMMUNOBIOLOGY 504
ALLERGIC DISEASE 509
EOSINOPHILIA 521
MAST CELL DISORDERS 522
SYSTEMIC AUTOIMMUNE DISEASE 522
PRIMARY VASCULITIS 534
AUTOINFLAMMATORY DISORDERS 540
IMMUNODEFICIENCY 541
HIV/AIDS 544
SELF-ASSESSMENT QUESTIONS 551
CHAPTER 18. MUSCULOSKELETAL MEDICINE 557
AN APPROACH TO A PATIENT WITH PAINFUL JOINTS 558
RHEUMATOID ARTHRITIS (RA) 560
SPONDYLOARTHROPATHIES 565
RELAPSING POLYCHONDRITIS (RP) 574
OSTEOARTHRITIS (OA) 574
GENETIC CONNECTIVE TISSUE DISORDERS 578
PAINFUL SHOULDERS 578
TENNIS ELBOW AND GOLFER’S ELBOW 581
PLANTAR FASCIITIS 581
FIBROMYALGIA 582
SEPTIC ARTHRITIS 584
ACUTE LOW BACK PAIN 585
CHRONIC LOW BACK PAIN 587
SELF- ASSESSMENT QUESTIONS 589
CHAPTER 19. NEUROLOGY 593
DISORDERS OF CONSCIOUSNESS 594
HEADACHE 596
STROKE 602
INTRACEREBRAL HEMORRHAGE 606
SUBARACHNOID HEMORRHAGE (SAH) 606
TRANSIENT ISCHEMIC ATTACK (TIA) 606
DEMENTIA 607
SEIZURES AND THE EPILEPSIES 611
BALANCE, DIZZINESS AND VERTIGO 618
MOVEMENT DISORDERS 623
MULTIPLE SCLEROSIS AND CNS INFLAMMATION 630
NEUROLOGICAL MANIFESTATIONS OF SARCOIDOSIS AND BEHÇET’S DISEASE 635
NEUROMUSCULAR DISEASE 635
NEUROMUSCULAR DISORDERS 639
SELF-ASSESSMENT QUESTIONS 646
CHAPTER 20. PSYCHIATRY FOR THE INTERNIST 651
DEPRESSION 651
ANXIETY DISORDERS 652
POST-TRAUMATIC STRESS DISORDER (PTSD) 652
SOMATIZATION 653
EATING DISORDERS 653
SUICIDE AND DELIBERATE SELF-HARM 654
PSYCHOTROPIC AGENTS 655
SELF-ASSESSMENT QUESTIONS 658
CHAPTER 21. CLINICAL INFECTIOUS DISEASES 659
CLINICAL APPROACH TO INFECTIOUS DISEASES 660
DIAGNOSTICS IN INFECTIOUS DISEASES 661
SELECTED COMMON CLINICALLY IMPORTANT ORGANISMS 662
ANTI-INFECTIVE TREATMENT 668
ANTI-INFECTIVE AGENTS 671
SPECIFIC SYNDROMES 681
INFECTIONS IN SPECIAL HOSTS AND POPULATIONS 685
SYSTEMIC VIRAL INFECTIONS 692
INFECTION PREVENTIONAND CONTROL 696
SELF-ASSESSMENT QUESTIONS 698
CHAPTER 22. IMMUNIZATION 701
GENERAL PRINCIPLES 701
IMMUNIZING AGENTS 702
FACTORS AFFECTING IMMUNOGENICITY 703
BOOSTER DOSES 704
IMMUNIZATION IN SPECIFIC POPULATIONS 704
POST-EXPOSURE PROPHYLAXIS (PEP) 707
ROUTINE IMMUNIZATION OF ADULTS 707
SELF-ASSESSMENT QUESTIONS 711
CHAPTER 23. DERMATOLOGY FOR THE PHYSICIAN 715
ACNE 715
AUTOIMMUNE DISEASES OF THE SKIN 715
SKIN PROBLEMS ASSOCIATED WITH UNDERLYING SYSTEMIC DISEASE 719
GENETIC OR CONGENITAL SKIN DISEASES 722
SKIN DISEASE ASSOCIATED WITH MALIGNANCY 723
SELF-ASSESSMENT QUESTIONS 725
CHAPTER 24. MEDICAL OPHTHALMOLOGY 727
INTRODUCTIONE 727
OCULAR HISTORY 728
OCULAR EXAMINATION 728
PATHOLOGICAL CONDITIONS 732
UVEITIS 735
RETINITIS 736
SCLERITIS AND SCLEROUVEITIS 736
THYROID-RELATED ORBITOPATHY 736
DRY EYE 737
NEOPLASIA AND THE EYE 737
NEURO-OPHTHALMOLOGY 738
PHAKOMATOSES 739
OCULAR EFFECTS OF SYSTEMIC MEDICATION 739
SELF-ASSESSMENT QUESTIONS 741
CHAPTER 25. WOMEN’S HEALTH FOR THE PHYSICIAN 743
INFERTILITY 743
CONTRACEPTION 745
MENOPAUSAL SYMPTOMS 748
PREMENSTRUAL SYNDROME 749
ABNORMAL UTERINE BLEEDING 749
DYSMENORRHEA 750
VULVAR CONDITIONS 750
SEXUALLY TRANSMITTED INFECTIONS (STIs) 753
PELVIC INFLAMMATORY DISEASE (PID) 754
SEXUAL PROBLEMS 755
SELF-ASSESSMENT QUES 757
CHAPTER 26. OBSTETRIC MEDICINE 759
GENERAL PRINCIPLES OF MEDICAL OBSTETRIC CARE 760
DIABETES IN PREGNANCY 760
HYPERTENSION IN PREGNANCY 763
RESPIRATORY DISEASE IN PREGNANCY 764
VENOUS THROMBOEMBOLISM (VTE) IN PREGNANCY 766
THYROID DISORDERS IN PREGNANCY 766
COMMON GASTROENTEROLOGICAL AND LIVER DISORDERS IN PREGNANCY 767
VIRAL INFECTION IN PREGNANCY 769
IMMUNOLOGICAL AND HEMATOLOGICAL DISEASE IN PREGNANCY 770
CARDIAC DISEASE IN PREGNANCY 771
OBESITY IN PREGNANCY 773
NEUROLOGICAL CONDITIONS IN PREGNANCY 773
SELF-ASSESSMENT QUESTIONS 774
CHAPTER 27. GERIATRIC MEDICINE 777
INTRODUCTION 777
EPIDEMIOLOGY OF AGING 778
AGING AND DISEASE 778
PHYSIOLOGY OF AGING 779
PATHOLOGY: DISEASE IN OLDER PEOPLE 780
THE GIANTS OF GERIATRICS 780
ELDER ABUSE 786
OSTEOPOROSIS 786
COMPREHENSIVE GERIATRIC ASSESSMENT 786
HEALTHY AGING 787
FACING THE INEVITABLE WITH DIGNITY 788
SELF-ASSESSMENT QUESTIONS 789
INDEX 791