Robbins Basic Pathology E-Book

Vinay Kumar; Abul K. Abbas; Nelson Fausto; Richard Mitchell

BOOK

Robbins Basic Pathology E-Book

Vinay Kumar | Abul K. Abbas | Nelson Fausto | Richard Mitchell

(2011)

Additional Information

Book Details

ISBN: 978-1-4557-2640-0
Edition: 8
Language: English
Pages: 960
Subjects: Pathology
Pharmacology
Medical study & revision guides & reference material

Abstract

Get the pathology knowledge you need, the way you need it, from the name you can trust! Robbins Basic Pathology has helped countless students master the core concepts in pathology. This 8th Edition continues that tradition, providing outstanding, user-friendly coverage of the latest information in the field. Clinicopathologic correlations highlight the relationships between basic science and clinical medicine, while state-of-the-art gross and photomicrographic illustrations help you understand complex principles.

Get a rich understanding of all essential pathology concepts with expert guidance from an all-star editorial team.

Grasp the connections between basic science and clinical medicine with clinicopathologic correlations throughout.

Master complex principles visually with the aid of more than 1,000 high-quality, full-color illustrations, photographs, and photomicrographs.

Understand all the key points with NEW Summary Boxes in every chapter.

Summary boxes highlight key information throughout each chapter.
Illustrations have been improved and simplified throughout providing improved visual clarification of important concepts.
A plethora of extras available on Student Consult including self assessment questions, Pathology case studies and Virtual Microscope functionality for most of the high quality photomicrographs.
Valuable Instructor teaching resources on EVOLVE including all of the images from the book and a test bank with page references to the text.

Section Title	Page	Action	Price
Front cover	Cover
Title page	iii
Copyright page	iv
DEDICATION	v
Contributors	vii
Preface	ix
Acknowledgments	xi
Table of contents	xiii
Chapter 1: Cell Injury, Cell Death, and Adaptations	1
INTRODUCTION TO PATHOLOGY	1
OVERVIEW OF CELLULAR RESPONSES TO STRESS AND NOXIOUS STIMULI	1
CELLULAR ADAPTATIONS TO STRESS	3
SUMMARY	6
OVERVIEW OF CELL INJURY AND CELL DEATH	6
CAUSES OF CELL INJURY	7
THE MORPHOLOGY OF CELL AND TISSUE INJURY	7
SUMMARY	10
SUMMARY	13
MECHANISMS OF CELL INJURY	13
SUMMARY	18
EXAMPLES OF CELL INJURY AND NECROSIS	18
APOPTOSIS	19
SUMMARY	22
INTRACELLULAR ACCUMULATIONS	23
PATHOLOGIC CALCIFICATION	26
SUMMARY	27
CELLULAR AGING	28
SUMMARY	29
Chapter 2: Acute and Chronic Inflammation	31
OVERVIEW OF INFLAMMATION	31
SUMMARY	32
ACUTE INFLAMMATION	33
SUMMARY	35
SUMMARY	37
SUMMARY	41
SUMMARY	42
MORPHOLOGIC PATTERNS OF ACUTE INFLAMMATION	43
CHEMICAL MEDIATORS OF INFLAMMATION	44
SUMMARY	50
SUMMARY	53
CHRONIC INFLAMMATION	53
SUMMARY	57
SYSTEMIC EFFECTS OF INFLAMMATION	57
SUMMARY	58
Chapter 3: Tissue Repair: Regeneration, Healing, and Fibrosis	59
THE CONTROL OF CELL PROLIFERATION	59
SUMMARY	63
THE NATURE AND MECHANISMS OF ACTION OF GROWTH FACTORS	63
SUMMARY	65
EXTRACELLULAR MATRIX (ECM) AND CELL-MATRIX INTERACTIONS	65
SUMMARY	68
CELL AND TISSUE REGENERATION	68
REPAIR BY CONNECTIVE TISSUE	70
SUMMARY	74
CUTANEOUS WOUND HEALING	74
PATHOLOGIC ASPECTS OF REPAIR	77
SUMMARY	78
OVERVIEW OF REPAIR PROCESSES	78
Chapter 4: Hemodynamic Disorders, Thrombosis, and Shock	81
EDEMA	81
SUMMARY	84
HYPEREMIA AND CONGESTION	84
HEMORRHAGE	85
HEMOSTASIS AND THROMBOSIS	86
SUMMARY	89
SUMMARY	90
SUMMARY	93
SUMMARY	98
EMBOLISM	98
SUMMARY	100
INFARCTION	100
SUMMARY	102
SHOCK	102
SUMMARY	105
Chapter 5: Diseases of the Immune System	107
INNATE AND ADAPTIVE IMMUNITY	108
CELLS AND TISSUES OF THE IMMUNE SYSTEM	109
SUMMARY	114
OVERVIEW OF NORMAL IMMUNE RESPONSES	114
SUMMARY	119
HYPERSENSITIVITY DISEASES: MECHANISMS OF IMMUNEMEDIATED INJURY	119
SUMMARY	124
SUMMARY	125
SUMMARY	131
REJECTION OF TRANSPLANTS	131
SUMMARY	134
Chapter 6: Neoplasia	173
NOMENCLATURE	174
CHARACTERISTICS OF BENIGN AND MALIGNANT NEOPLASMS	176
SUMMARY	181
EPIDEMIOLOGY	181
SUMMARY	185
CARCINOGENESIS: THE MOLECULAR BASIS OF CANCER	185
SUMMARY	186
SUMMARY	191
SUMMARY	192
SUMMARY	194
SUMMARY	196
SUMMARY	198
SUMMARY	199
SUMMARY	200
SUMMARY	201
SUMMARY	204
SUMMARY	205
SUMMARY	208
ETIOLOGY OF CANCER: CARCINOGENIC AGENTS	208
Chapter 7: Genetic and Pediatric Diseases	225
GENETIC DISEASES	226
MUTATIONS	227
MENDELIAN DISORDERS (DISEASES CAUSED BY SINGLE-GENE DEFECTS)	228
SUMMARY	230
SUMMARY	232
SUMMARY	233
SUMMARY	235
SUMMARY	239
SUMMARY	240
DISORDERS WITH MULTIFACTORIAL INHERITANCE	240
CYTOGENETIC DISORDERS	241
SUMMARY	246
SUMMARY	248
SINGLE-GENE DISORDERS WITH ATYPICAL PATTERNS OF INHERITANCE	248
SUMMARY	250
SUMMARY	252
PEDIATRIC DISEASES	252
CONGENITAL ANOMALIES	253
SUMMARY	256
PERINATAL INFECTIONS	256
PREMATURITY AND FETAL GROWTH RESTRICTION	256
RESPIRATORY DISTRESS SYNDROME OF THE NEWBORN	257
SUMMARY	259
NECROTIZING ENTEROCOLITIS	259
SUDDEN INFANT DEATH SYNDROME	259
SUMMARY	261
FETAL HYDROPS	261
SUMMARY	264
CYSTIC FIBROSIS	264
SUMMARY	267
TUMORS AND TUMOR-LIKE LESIONS OF INFANCY AND CHILDHOOD	267
SUMMARY	270
SUMMARY	273
DIAGNOSIS OF GENETIC DISEASES	273
Chapter 8: Environmental and Nutritional Diseases	279
GENERAL MECHANISMS OF TOXICITY	280
ENVIRONMENTAL POLLUTION	281
SUMMARY	283
SUMMARY	286
EFFECTS OF TOBACCO	287
SUMMARY	290
EFFECTS OF ALCOHOL	290
SUMMARY	292
INJURY BY THERAPEUTIC DRUGS AND DRUGS OF ABUSE	292
SUMMARY	297
INJURY BY PHYSICAL AGENTS	297
SUMMARY	303
NUTRITIONAL DISEASES	303
SUMMARY	313
SUMMARY	317
Chapter 9: General Pathology of Infectious Diseases*	319
HISTORY	320
NEW AND EMERGING INFECTIOUS DISEASES	320
AGENTS OF BIOTERRORISM	321
CATEGORIES OF INFECTIOUS AGENTS	321
TRANSMISSION OF MICROBES	326
SUMMARY	329
IMMUNE EVASION BY MICROBES	330
SUMMARY	331
HOW MICROORGANISMS CAUSE DISEASE	331
SUMMARY	336
TECHNIQUES FOR DIAGNOSING INFECTIOUS AGENTS	337
Chapter 10: The Blood Vessels	339
NORMAL VESSELS	340
CONGENITAL ANOMALIES	341
VASCULAR WALL CELLS AND THEIR RESPONSE TO INJURY	341
SUMMARY	342
ARTERIOSCLEROSIS	343
ATHEROSCLEROSIS	343
SUMMARY	353
HYPERTENSIVE VASCULAR DISEASE	353
SUMMARY	357
ANEURYSMS AND DISSECTIONS	357
VASCULITIS	362
SUMMARY	369
RAYNAUD PHENOMENON	369
VEINS AND LYMPHATICS	370
TUMORS	371
SUMMARY	377
PATHOLOGY OF VASCULAR INTERVENTION	377
Chapter 11: The Heart	379
HEART FAILURE	380
SUMMARY	382
CONGENITAL HEART DISEASE	382
SUMMARY	388
ISCHEMIC HEART DISEASE (IHD)	388
SUMMARY	398
HYPERTENSIVE HEART DISEASE	398
SUMMARY	400
VALVULAR HEART DISEASE	400
SUMMARY	409
CARDIOMYOPATHIES	409
SUMMARY	415
PERICARDIAL DISEASE	416
CARDIAC TUMORS	417
CARDIAC TRANSPLANTATION	418
Chapter 12: The Hematopoietic and Lymphoid Systems	421
RED CELL DISORDERS	422
SUMMARY	423
ANEMIA OF BLOOD LOSS: HEMORRHAGE	423
THE HEMOLYTIC ANEMIAS	424
SUMMARY	434
ANEMIAS OF DIMINISHED ERYTHROPOIESIS	435
SUMMARY	440
POLYCYTHEMIA	440
WHITE CELL DISORDERS	441
NON-NEOPLASTIC DISORDERS OF WHITE CELLS	441
NEOPLASTIC PROLIFERATIONS OF WHITE CELLS	444
SUMMARY	460
SUMMARY	467
BLEEDING DISORDERS	468
DISSEMINATED INTRAVASCULAR COAGULATION	469
THROMBOCYTOPENIA	471
COAGULATION DISORDERS	473
SUMMARY	475
DISORDERS THAT AFFECT THE SPLEEN AND THYMUS	475
SPLENOMEGALY	475
DISORDERS OF THE THYMUS	476
Chapter 13: The Lung	479
ATELECTASIS (COLLAPSE)	480
ACUTE LUNG INJURY	481
SUMMARY	483
OBSTRUCTIVE VERSUS RESTRICTIVE PULMONARY DISEASES	483
OBSTRUCTIVE PULMONARY DISEASE	484
SUMMARY	487
SUMMARY	489
SUMMARY	492
DIFFUSE INTERSTITIAL (RESTRICTIVE, INFILTRATIVE) LUNG DISEASES	494
SUMMARY	496
SUMMARY	500
SUMMARY	502
DISEASES OF VASCULAR ORIGIN	504
SUMMARY	506
PULMONARY INFECTIONS	508
SUMMARY	514
SUMMARY	522
LUNG TUMORS	528
SUMMARY	534
PLEURAL LESIONS	534
LESIONS OF THE UPPER RESPIRATORY TRACT	536
Chapter 14: The Kidney and Its Collecting System	541
CLINICAL MANIFESTATIONS OF RENAL DISEASES	542
GLOMERULAR DISEASES	542
SUMMARY	549
SUMMARY	554
SUMMARY	557
SUMMARY	559
DISEASES AFFECTING TUBULES AND INTERSTITIUM	559
SUMMARY	564
SUMMARY	566
DISEASES INVOLVING BLOOD VESSELS	566
SUMMARY	568
CYSTIC DISEASES OF THE KIDNEY	569
SUMMARY	571
URINARY OUTFLOW OBSTRUCTION	571
TUMORS	573
SUMMARY	575
Chapter 15: The Oral Cavity and the Gastrointestinal Tract*	579
ORAL CAVITY	580
ULCERATIVE AND INFLAMMATORY LESIONS	580
LEUKOPLAKIA AND ERYTHROPLAKIA	581
CANCERS OF THE ORAL CAVITY AND TONGUE	582
SUMMARY	583
SALIVARY GLAND DISEASES	583
SUMMARY	585
ESOPHAGUS	585
ANATOMIC AND MOTOR DISORDERS	585
VARICES	587
ESOPHAGITIS	588
BARRETT ESOPHAGUS	588
ESOPHAGEAL CARCINOMA	589
SUMMARY	591
STOMACH	591
GASTRITIS	591
GASTRIC ULCERATION	593
SUMMARY	597
GASTRIC TUMORS	597
SUMMARY	600
SMALL AND LARGE INTESTINES	600
DEVELOPMENTAL ANOMALIES	600
VASCULAR DISORDERS	601
COLONIC DIVERTICULOSIS	603
BOWEL OBSTRUCTION	604
ENTEROCOLITIS (DIARRHEAL DISEASES)	605
SUMMARY	609
INFLAMMATORY BOWEL DISEASE	611
SUMMARY	616
TUMORS OF THE SMALL AND LARGE INTESTINES	617
SUMMARY	624
APPENDIX	628
ACUTE APPENDICITIS	628
TUMORS OF THE APPENDIX	628
Chapter 16: The Liver, Gallbladder, and Biliary Tract	631
THE LIVER	632
PATTERNS OF HEPATIC INJURY	632
CLINICAL SYNDROMES	633
SUMMARY	636
SUMMARY	639
INFECTIOUS AND INFLAMMATORY DISORDERS	639
SUMMARY	648
ALCOHOL- AND DRUG-INDUCED LIVER DISEASE	648
SUMMARY	654
METABOLIC AND INHERITED LIVER DISEASE	654
SUMMARY	658
DISEASES OF THE INTRAHEPATIC BILIARY TRACT	658
CIRCULATORY DISORDERS	660
SUMMARY	663
TUMORS AND HEPATIC NODULES	663
Summary	666
DISORDERS OF THE GALLBLADDER AND THE EXTRAHEPATIC BILIARY TRACT	667
GALLBLADDER DISEASES	667
DISORDERS OF EXTRAHEPATIC BILE DUCTS	670
SUMMARY	670
TUMORS	671
Chapter 17: The Pancreas*	675
CONGENITAL ANOMALIES	676
PANCREATITIS	676
SUMMARY	681
PANCREATIC NEOPLASMS	681
SUMMARY	685
Chapter 18: The Male Genital System*	687
PENIS	687
SUMMARY	689
SCROTUM, TESTIS, AND EPIDIDYMIS	689
SUMMARY	690
SUMMARY	695
PROSTATE	695
SUMMARY	696
SUMMARY	697
SUMMARY	700
SEXUALLY TRANSMITTED DISEASES (STDs)	700
SUMMARY	705
SUMMARY	706
SUMMARY	707
SUMMARY	708
SUMMARY	709
Chapter 19: The Female Genital System and Breast	711
VULVA	712
VULVITIS	712
NON-NEOPLASTIC EPITHELIAL DISORDERS	712
SUMMARY	713
TUMORS	713
SUMMARY	715
VAGINA	715
VAGINITIS	715
VAGINAL INTRAEPITHELIAL NEOPLASIA AND SQUAMOUS CELL CARCINOMA	716
SARCOMA BOTRYOIDES	716
CERVIX	716
CERVICITIS	716
TUMORS OF THE CERVIX	717
SUMMARY	720
BODY OF UTERUS	721
ENDOMETRITIS	721
ADENOMYOSIS	721
ENDOMETRIOSIS	722
DYSFUNCTIONAL UTERINE BLEEDING AND ENDOMETRIAL HYPERPLASIA	722
SUMMARY	723
TUMORS OF THE ENDOMETRIUM AND MYOMETRIUM	724
SUMMARY	725
SUMMARY	727
FALLOPIAN TUBES	727
SUMMARY	728
OVARIES	728
FOLLICLE AND LUTEAL CYSTS	728
POLYCYSTIC OVARIES	728
TUMORS OF THE OVARY	728
SURFACE EPITHELIAL-STROMAL TUMORS	729
OTHER OVARIAN TUMORS	732
SUMMARY	734
DISEASES OF PREGNANCY	734
PLACENTAL INFLAMMATIONS AND INFECTIONS	734
ECTOPIC PREGNANCY	734
SUMMARY	735
GESTATIONAL TROPHOBLASTIC DISEASE	735
SUMMARY	737
PREECLAMPSIA/ECLAMPSIA (TOXEMIA OF PREGNANCY)	737
SUMMARY	738
BREAST	739
FIBROCYSTIC CHANGES	739
SUMMARY	741
INFLAMMATIONS	742
TUMORS OF THE BREAST	742
SUMMARY	749
MALE BREAST	750
Chapter 20: The Endocrine System	751
PITUITARY	752
HYPERPITUITARISM AND PITUITARY ADENOMAS	753
SUMMARY	755
SUMMARY	756
HYPOPITUITARISM	756
POSTERIOR PITUITARY SYNDROMES	757
THYROID	758
HYPERTHYROIDISM	758
HYPOTHYROIDISM	759
THYROIDITIS	760
SUMMARY	762
GRAVES DISEASE	763
SUMMARY	764
DIFFUSE AND MULTINODULAR GOITER	764
NEOPLASMS OF THE THYROID	765
SUMMARY	771
PARATHYROID GLANDS	771
HYPERPARATHYROIDISM	772
SUMMARY	774
HYPOPARATHYROIDISM	775
ENDOCRINE PANCREAS	775
DIABETES MELLITUS	775
SUMMARY	781
PANCREATIC ENDOCRINE NEOPLASMS	787
ADRENAL CORTEX	789
ADRENOCORTICAL HYPERFUNCTION (HYPERADRENALISM)	789
SUMMARY	791
SUMMARY	793
ADRENAL INSUFFICIENCY	793
SUMMARY	795
ADRENOCORTICAL NEOPLASMS	795
ADRENAL MEDULLA	796
PHEOCHROMOCYTOMA	797
NEUROBLASTOMA AND OTHER NEURONAL NEOPLASMS	798
MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES	798
MULTIPLE ENDOCRINE NEOPLASIA TYPE 1	798
MULTIPLE ENDOCRINE NEOPLASIA TYPE 2	798
Chapter 21: The Musculoskeletal System*	801
BONES	802
CONGENITAL DISEASES OF BONE	802
SUMMARY	803
ACQUIRED DISEASES OF BONE DEVELOPMENT	803
SUMMARY	808
FRACTURES	809
OSTEONECROSIS (AVASCULAR NECROSIS)	809
OSTEOMYELITIS	810
BONE TUMORS	811
SUMMARY	818
JOINTS	818
ARTHRITIS	818
SUMMARY	824
JOINT TUMORS AND TUMOR-LIKE LESIONS	824
SKELETAL MUSCLE	826
MUSCLE ATROPHY	826
MUSCULAR DYSTROPHY	827
SUMMARY	829
MYOPATHY	829
DISEASES OF THE NEUROMUSCULAR JUNCTION	830
SKELETAL MUSCLE TUMORS	831
SOFT TISSUE TUMORS	831
FATTY TUMORS	832
FIBROUS TUMORS AND TUMOR-LIKE LESIONS	833
FIBROHISTIOCYTIC TUMORS	834
SMOOTH MUSCLE TUMORS	835
SYNOVIAL SARCOMA	835
Chapter 22: The Skin	837
ACUTE INFLAMMATORY DERMATOSES	838
CHRONIC INFLAMMATORY DERMATOSES	840
SUMMARY	842
INFECTIOUS DERMATOSES	843
BLISTERING (BULLOUS) DISORDERS	844
SUMMARY	847
TUMORS	848
SUMMARY	850
SUMMARY	852
SUMMARY	857
Chapter 23: The Nervous System*	859
PATTERNS OF INJURY IN THE NERVOUS SYSTEM	860
EDEMA, HERNIATION, AND HYDROCEPHALUS	861
SUMMARY	863
CEREBROVASCULAR DISEASES	863
SUMMARY	868
CENTRAL NERVOUS SYSTEM TRAUMA	869
SUMMARY	871
CONGENITAL MALFORMATIONS AND PERINATAL BRAIN INJURY	871
SUMMARY	873
INFECTIONS OF THE NERVOUS SYSTEM	873
SUMMARY	881
TUMORS	882
SUMMARY	887
PRIMARY DISEASES OF MYELIN	887
SUMMARY	890
ACQUIRED METABOLIC AND TOXIC DISTURBANCES	890
DEGENERATIVE DISEASES AND DEMENTIAS	891
SUMMARY	897
DISEASES OF THE PERIPHERAL NERVOUS SYSTEM	897
FAMILIAL TUMOR SYNDROMES	900
SUMMARY	901
Index	903

Robbins Basic Pathology E-Book

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