BOOK
Dermatological Signs of Internal Disease E-Book
Jeffrey P. Callen | Joseph L. Jorizzo | Jean L. Bolognia | Warren Piette | John J. Zone
(2009)
Additional Information
Book Details
Abstract
Practical, comprehensive, and updated throughout, the 4th edition of Dermatological Signs of Internal Diseases helps you identify a full range of common and rare systemic diseases early…so they can be managed as effectively as possible. Coverage of new disorders, including nephrogenic fibrosing dermopathy, new treatment options, expanded histopathology content, new color images, online image library and much more...to help you attain definitive diagnoses of internal diseases that manifest on the skin. Best of all, each chapter features an evidence-based approach to diagnosis and treatment so you know you can depend on the clinical recommendations presented. Expert Consult functionality allows you to access the entire contents of the book online at expertconsult.com from any Internet connection.
- Presents an evidence-based approach so you can depend on the clinical recommendations presented.
- Covers advice on patient evaluation and lab tests, as well as tables of differential diagnoses, to facilitate diagnosis for every condition.
- Uses a consistent, user-friendly format for easy reference.
- Discusses new diseases such as nephrogenic fibrosing dermopathy and new therapies, including biologics, to keep you on the cusp of this rapidly expanding field.
- Provides improved and expanded histopathology content for a better understanding in this difficult area of diagnosis.
- Features over 500 full-color illustrations—100 new to this edition—that provide the best possible representations of diseases as they appear in real life.
- Features a companion website at expertconsult.com with fully searchable text and an image library to enhanced visual guidance.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front cover | cover | ||
| Half title page | i | ||
| Title page | iii | ||
| Copyright page | iv | ||
| Table of contents | v | ||
| Preface | vii | ||
| Acknowledgments | viii | ||
| List of Contributors | ix | ||
| Chapter 1: Lupus Erythematosus | 1 | ||
| CHRONIC CUTANEOUS LUPUS ERYTHEMATOSUS | 1 | ||
| SUBACUTE CUTANEOUS LUPUS ERYTHEMATOSUS | 4 | ||
| NEONATAL LUPUS ERYTHEMATOSUS | 6 | ||
| ACUTE CUTANEOUS LUPUS ERYTHEMATOSUS | 6 | ||
| OTHER CUTANEOUS CHANGES ASSOCIATED WITH LUPUS ERYTHEMATOSUS | 7 | ||
| LABORATORY PHENOMENA IN PATIENTS WITH CUTANEOUS LUPUS ERYTHEMATOSUS | 8 | ||
| TREATMENT OF CUTANEOUS LUPUS ERYTHEMATOSUS | 9 | ||
| SUGGESTED READINGS | 10 | ||
| Chapter 2: Dermatomyositis | 11 | ||
| DEFINITION AND CLASSIFICATION | 11 | ||
| PATHOGENESIS | 11 | ||
| MANIFESTATIONS | 12 | ||
| AMYOPATHIC DERMATOMYOSITIS | 15 | ||
| MYOSITIS AND MALIGNANCY | 15 | ||
| EVALUATION OF THE PATIENT WITH MYOSITIS | 16 | ||
| COURSE AND TREATMENT | 17 | ||
| SUGGESTED READINGS | 19 | ||
| Chapter 3: Scleroderma, Raynaud’s Phenomenon, and Related Conditions | 21 | ||
| SCLERODERMA | 21 | ||
| EOSINOPHILIC FASCIITIS | 26 | ||
| RAYNAUD’S PHENOMENON AND DISEASE | 27 | ||
| MIXED CONNECTIVE TISSUE DISEASE (MCTD) | 28 | ||
| NEPHROGENIC SYSTEMIC FIBROSIS (NSF) (see also Chapter 32) | 28 | ||
| SUGGESTED READINGS | 28 | ||
| Chapter 4: Vasculitis | 31 | ||
| CLASSIFICATION | 31 | ||
| PATHOGENESIS | 31 | ||
| ETIOLOGIC ASSOCIATIONS | 32 | ||
| CLINICAL MANIFESTATIONS | 33 | ||
| VASCULITIS VARIANTS | 36 | ||
| DIFFERENTIAL DIAGNOSIS AND EVALUATION | 36 | ||
| TREATMENT | 37 | ||
| SUGGESTED READINGS | 38 | ||
| Chapter 5: Miscellaneous Disorders With Prominent Features Involving the Skin and the Joints | 39 | ||
| RHEUMATOID ARTHRITIS | 39 | ||
| PSORIATIC ARTHRITIS | 42 | ||
| BEHÇET’S DISEASE | 43 | ||
| SWEET’S SYNDROME (ACUTE FEBRILE NEUTROPHILIC DERMATOSIS) | 45 | ||
| PYODERMA GANGRENOSUM | 46 | ||
| BOWEL BYPASS–BOWEL-ASSOCIATED DERMATOSIS–ARTHRITIS SYNDROME | 48 | ||
| REACTIVE arthritis (REITER’S SYNDROME) | 48 | ||
| KAWASAKI’S DISEASE (MUCOCUTANEOUS LYMPH-NODE SYNDROME) | 50 | ||
| GOUT | 51 | ||
| SUGGESTED READINGS | 51 | ||
| Chapter 6: Urticaria | 53 | ||
| PATHOGENESIS | 53 | ||
| CLASSIFICATION | 53 | ||
| DIFFERENTIAL DIAGNOSIS | 55 | ||
| PATIENT EVALUATION | 55 | ||
| TREATMENT | 56 | ||
| SUGGESTED READINGS | 62 | ||
| Chapter 7: Erythema Multiforme, Stevens–Johnson Syndrome, and Toxic Epidermal Necrolysis | 63 | ||
| PATHOGENESIS | 63 | ||
| CLINICAL MANIFESTATIONS | 64 | ||
| SUGGESTED READINGS | 68 | ||
| Chapter 8: Erythema Nodosum and Other Panniculitides | 69 | ||
| ERYTHEMA NODOSUM | 69 | ||
| LOBULAR PANNICULITIDES | 72 | ||
| SUGGESTED READINGS | 73 | ||
| Chapter 9: Pruritus | 75 | ||
| SKIN SIGNS OF CHRONIC PRURITUS | 75 | ||
| COMMON COMPLICATIONS IN PATIENTS WITH GENERALIZED PRURITUS | 75 | ||
| DIAGNOSIS | 75 | ||
| EXAMINATION | 76 | ||
| INVESTIGATIONS | 76 | ||
| PATHOPHYSIOLOGY OF GENERALIZED PRURITUS | 76 | ||
| END-STAGE RENAL FAILURE (ESRF) PRURITUS | 77 | ||
| PRURITUS OF CHOLESTASIS | 77 | ||
| NEUROPATHIC ITCH | 78 | ||
| LYMPHOMAS, LEUKEMIA, AND HEMATOLOGIC DISEASE | 78 | ||
| ENDOCRINE DISEASE | 78 | ||
| PRURITUS OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION | 78 | ||
| PREGNANCY | 78 | ||
| TREATMENT OF PRURITUS | 78 | ||
| SUGGESTED READINGS | 79 | ||
| Chapter 10: Erythroderma | 81 | ||
| CAUSE AND PATHOGENESIS | 81 | ||
| CLINICAL MANIFESTATIONS | 82 | ||
| HISTOPATHOLOGIC FINDINGS | 82 | ||
| EVALUATION | 82 | ||
| COURSE AND TREATMENT | 83 | ||
| SUGGESTED READINGS | 84 | ||
| Chapter 11: Purpura | 85 | ||
| PATHOGENESIS | 85 | ||
| CLINICAL MANIFESTATIONS | 90 | ||
| HISTORY AND PHYSICAL FINDINGS | 91 | ||
| HISTOPATHOLOGIC FINDINGS | 91 | ||
| DIFFERENTIAL DIAGNOSIS | 91 | ||
| EVALUATION | 91 | ||
| TREATMENT | 92 | ||
| SUGGESTED READINGS | 92 | ||
| Chapter 12: Bullous Diseases | 93 | ||
| PEMPHIGUS | 93 | ||
| BULLOUS PEMPHIGOID | 98 | ||
| EPIDERMOLYSIS BULLOSA ACQUISITA | 101 | ||
| DERMATITIS HERPETIFORMIS | 103 | ||
| LINEAR IgA BULLOUS DERMATOSIS | 104 | ||
| SUGGESTED READINGS | 106 | ||
| Chapter 13: Skin Signs of Internal Malignancy | 107 | ||
| PROLIFERATIVE AND INFLAMMATORY DERMATOSES | 107 | ||
| HORMONE-SECRETING SYNDROMES | 113 | ||
| INHERITED SYNDROMES ASSOCIATED WITH INTERNAL CANCER | 113 | ||
| CONCLUSIONS | 116 | ||
| SUGGESTED READINGS | 116 | ||
| Chapter 14: Metastatic Disease | 117 | ||
| EPIDEMIOLOGY | 117 | ||
| PATHOGENESIS | 117 | ||
| CLINICAL MANIFESTATIONS | 118 | ||
| DIFFERENTIAL DIAGNOSIS | 121 | ||
| HISTOPATHOLOGIC FINDINGS | 121 | ||
| EVALUATION AND PROGNOSIS | 121 | ||
| THERAPY | 122 | ||
| SUGGESTED READINGS | 122 | ||
| Chapter 15: Cutaneous Manifestations of Leukemias, Myelodysplastic and Myeloproliferative Syndromes, and Systemic Lymphomas | 125 | ||
| PATHOGENESIS | 125 | ||
| CLINICAL MANIFESTATIONS | 125 | ||
| DIFFERENTIAL DIAGNOSIS | 130 | ||
| HISTOPATHOLOGIC FINDINGS | 132 | ||
| EVALUATION | 132 | ||
| TREATMENT | 132 | ||
| SUGGESTED READINGS | 133 | ||
| Chapter 16: Dysproteinemias, Plasma Cell Disorders, and Amyloidosis | 135 | ||
| DISORDERS DIRECTLY RELATED TO MONOCLONAL PROTEINS | 135 | ||
| DISORDERS ASSOCIATED WITH MONOCLONAL PROTEIN PRODUCTION | 138 | ||
| AMYLOIDOSIS | 142 | ||
| SUGGESTED READINGS | 146 | ||
| Chapter 17: Cutaneous Manifestations of Macrophage/Dendritic Cell Proliferative Disorders (Histiocytoses) | 149 | ||
| PATHOGENESIS | 149 | ||
| CLASS I: LANGERHANS’ CELL GRANULOMATOSES | 149 | ||
| CLASS II AND III HISTIOCYTOSES: NON-LANGERHANS’ CELL DISEASES | 152 | ||
| SUGGESTED READINGS | 159 | ||
| Chapter 18: Vascular Neoplasms | 161 | ||
| TELANGIECTASIAS | 161 | ||
| HEMANGIOMAS AND VASCULAR MALFORMATIONS | 163 | ||
| KAPOSI’S SARCOMA | 169 | ||
| ANGIOSARCOMA | 172 | ||
| SUGGESTED READINGS | 173 | ||
| Chapter 19: Primary Cutaneous T-cell and B-cell Lymphomas | 175 | ||
| CLASSIFICATIONS OF CUTANEOUS LYMPHOMAS | 175 | ||
| PRIMARY CUTANEOUS T-CELL LYMPHOMAS | 176 | ||
| PRIMARY CUTANEOUS B-CELL LYMPHOMAS | 186 | ||
| SUGGESTED READINGS | 187 | ||
| Chapter 20: Diabetes Mellitus | 189 | ||
| DIABETIC FOOT | 189 | ||
| DIABETIC DERMOPATHY (SHIN SPOTS) | 189 | ||
| NECROBIOSIS LIPOIDICA (FORMERLY NECROBIOSIS LIPOIDICA DIABETICORUM) | 190 | ||
| Description | 190 | ||
| Frequency | 190 | ||
| Pathogenesis | 191 | ||
| Significance | 191 | ||
| Treatment | 191 | ||
| ACQUIRED ICHTHYOSIFORM CHANGES OF THE SHINS | 191 | ||
| ACANTHOSIS NIGRICANS | 191 | ||
| SKIN TAGS | 192 | ||
| SCLERODERMA-LIKE SKIN CHANGES | 192 | ||
| SCLEREDEMA (SCLEREDEMA ADULTORUM, SCLEREDEMA DIABETICORUM OF BUSCHKE) | 193 | ||
| DIABETIC BLISTERS (BULLOSIS DIABETICORUM) | 193 | ||
| ACQUIRED PERFORATING DERMATOSES | 194 | ||
| RUBEOSIS | 194 | ||
| YELLOW SKIN OF DIABETICS (CAROTENODERMA) | 194 | ||
| KERATOSIS PILARIS | 195 | ||
| ERUPTIVE XANTHOMAS | 195 | ||
| INFECTIONS | 195 | ||
| CUTANEOUS COMPLICATIONS OF ANTIDIABETIC THERAPY | 196 | ||
| DERMATOLOGIC DISEASES ASSOCIATED WITH DIABETES MELLITUS | 197 | ||
| MISCELLANEOUS CONDITIONS | 197 | ||
| SUGGESTED READINGS | 198 | ||
| Chapter 21: Thyroid and the Skin | 199 | ||
| SPECIFIC LESIONS | 200 | ||
| HYPERTHYROIDISM | 200 | ||
| HYPOTHYROIDISM | 202 | ||
| MISCELLANEOUS CUTANEOUS DISORDERS AND THE THYROID | 204 | ||
| SUGGESTED READINGS | 204 | ||
| Chapter 22: Lipids | 205 | ||
| DISORDERS OF LIPID METABOLISM | 205 | ||
| Clinical Manifestations | 207 | ||
| TREATMENT | 209 | ||
| SUGGESTED READINGS | 209 | ||
| Chapter 23: Adrenal, Androgen-related, and Pituitary Disorders | 211 | ||
| ADRENAL DISORDERS | 211 | ||
| ANDROGEN-RELATED DISORDERS | 213 | ||
| DISORDERS OF STEROID HORMONE RECEPTORS | 215 | ||
| PITUITARY DISORDERS WITH CUTANEOUS MANIFESTATIONS | 215 | ||
| SUGGESTED READINGS | 216 | ||
| Chapter 24: Porphyrias | 217 | ||
| PORPHYRIA CUTANEA TARDA | 217 | ||
| ERYTHROPOIETIC PROTOPORPHYRIA | 223 | ||
| CONGENITAL ERYTHROPOIETIC PORPHYRIA | 223 | ||
| VARIEGATE PORPHYRIA AND HEREDITARY COPROPORPHYRIA | 224 | ||
| SUGGESTED READINGS | 224 | ||
| Chapter 25: Cutaneous Diseases Associated with Gastrointestinal Abnormalities | 225 | ||
| GASTROINTESTINAL HEMORRHAGE | 225 | ||
| POLYPOSIS SYNDROMES | 229 | ||
| MALABSORPTION | 231 | ||
| INFLAMMATORY BOWEL DISEASE | 234 | ||
| SUGGESTED READINGS | 235 | ||
| Chapter 26: Cutaneous Hepatology | 237 | ||
| CIRRHOSIS | 237 | ||
| PRIMARY BILIARY CIRRHOSIS | 239 | ||
| HEMOCHROMATOSIS | 239 | ||
| WILSON’S DISEASE | 240 | ||
| CUTANEOUS DISEASE ASSOCIATED WITH VIRAL HEPATITIS | 240 | ||
| SUGGESTED READINGS | 242 | ||
| Chapter 27: Pancreatic Disease | 243 | ||
| CUTANEOUS LESIONS ASSOCIATED WITH PANCREATITIS | 243 | ||
| CUTANEOUS CHANGES RELATED TO PANCREATIC ENDOCRINE TUMORS | 245 | ||
| CUTANEOUS CHANGES RELATED TO NONHORMONE-SECRETING PANCREATIC CARCINOMA | 246 | ||
| SUGGESTED READINGS | 246 | ||
| Chapter 28: Cutaneous Manifestations of Systemic Viral, Bacterial, and Fungal Infections and Protozoan Disease | 247 | ||
| VIRUSES | 247 | ||
| BACTERIA | 253 | ||
| MYCOBACTERIA | 259 | ||
| FUNGI | 262 | ||
| PROTOZOAN DISEASE | 267 | ||
| SUGGESTED READINGS | 268 | ||
| Chapter 29: Acquired Immunodeficiency Syndrome and Sexually Transmitted Infections | 271 | ||
| ACQUIRED IMMUNODEFICIENCY SYNDROME | 271 | ||
| sexually transmitted infections | 279 | ||
| SUGGESTED READINGS | 285 | ||
| Chapter 30: Sarcoidosis | 287 | ||
| CAUSE AND PATHOGENESIS | 287 | ||
| CLINICAL MANIFESTATIONS | 287 | ||
| HISTOPATHOLOGIC FINDINGS | 293 | ||
| DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS | 293 | ||
| EVALUATION | 294 | ||
| PROGNOSIS | 294 | ||
| TREATMENT | 294 | ||
| SUGGESTED READINGS | 295 | ||
| Chapter 31: Cardiovascular Diseases and the Skin | 297 | ||
| ANTIPHOSPHOLIPID ANTIBODY SYNDROME | 297 | ||
| CARCINOID SYNDROME | 297 | ||
| DEGOS DISEASE (MALIGNANT ATROPHIC PAPULOSIS) | 297 | ||
| EARLOBE CREASES | 300 | ||
| MALE PATTERN BALDNESS | 300 | ||
| HEMOCHROMATOSIS | 300 | ||
| RELAPSING POLYCHONDRITIS | 300 | ||
| EMBOLIC PHENOMENA | 301 | ||
| EHLERS–DANLOS SYNDROME | 301 | ||
| LOEYS–DIETZ SYNDROME | 301 | ||
| LEOPARD AND NOONAN SYNDROMES | 301 | ||
| CARNEY COMPLEX | 301 | ||
| WERNER’S SYNDROME | 302 | ||
| PSEUDOXANTHOMA ELASTICUM | 302 | ||
| PSORIASIS AND HEART DISEASE | 302 | ||
| MYOSITIS | 302 | ||
| SUGGESTED READING | 302 | ||
| Chapter 32: Renal Disease and the Skin | 305 | ||
| INTRODUCTION | 305 | ||
| HERITABLE DISORDERS WITH RENAL AND CUTANEOUS FEATURES | 305 | ||
| skin disorders associated with acute and chronic renal failure | 305 | ||
| SUGGESTED READINGS | 309 | ||
| Chapter 33: Manifestations in Transplant Recipients | 311 | ||
| INFECTIONS | 311 | ||
| NEOPLASMS | 319 | ||
| GRAFT-VERSUS-HOST DISEASE | 321 | ||
| DRUG EFFECTS | 323 | ||
| SUGGESTED READINGS | 323 | ||
| Chapter 34: Neurocutaneous Disease | 325 | ||
| CLASSIFICATION | 325 | ||
| NEUROFIBROMATOSIS (VON RECKLINGHAUSEN’S DISEASE) | 325 | ||
| TUBEROUS SCLEROSIS (BOURNEVILLE’S DISEASE) | 329 | ||
| STURGE–WEBER DISEASE | 333 | ||
| COBB’S SYNDROME | 335 | ||
| ATAXIA–TELANGIECTASIA (LOUIS–BAR SYNDROME) | 335 | ||
| OTHER NEUROCUTANEOUS DISEASES | 336 | ||
| SUGGESTED READINGS | 338 | ||
| Chapter 35: Pregnancy | 339 | ||
| PHYSIOLOGIC SKIN CHANGES | 339 | ||
| PRURITUS IN PREGNANCY | 341 | ||
| CUTANEOUS TUMORS AFFECTED BY PREGNANCY | 342 | ||
| PRE-EXISTING SKIN DISEASES AND INTERNAL DISEASES WITH SKIN MANIFESTATIONS AFFECTED BY PREGNANCY | 343 | ||
| SPECIFIC DERMATOSES OF PREGNANCY | 345 | ||
| SUGGESTED READINGS | 348 | ||
| Chapter 36: Mast Cell Disease | 349 | ||
| PATHOGENESIS | 349 | ||
| CLASSIFICATION OF MAST CELL DISEASE | 349 | ||
| CLINICAL MANIFESTATIONS | 350 | ||
| DIAGNOSIS | 352 | ||
| PROGNOSIS | 353 | ||
| TREATMENT | 353 | ||
| SUGGESTED READING | 354 | ||
| Chapter 37: Hair Disorders in Systemic Disease | 355 | ||
| FOLLICULAR BIOLOGY | 355 | ||
| HAIR DISORDERS AND SYSTEMIC DISEASE | 356 | ||
| ALOPECIA | 356 | ||
| EXCESSIVE HAIR | 362 | ||
| SUGGESTED READING | 364 | ||
| Chapter 38: Nail Signs of Systemic Disease | 365 | ||
| ANATOMIC CHANGES OF THE NAIL APPARATUS (Table 38–1) | 365 | ||
| CHANGES IN SPECIFIC DISORDERS | 370 | ||
| SUGGESTED READINGS | 373 | ||
| Chapter 39: Oral Mucous Membranes and Systemic Disease | 375 | ||
| NEVOID BASAL CELL CARCINOMA SYNDROME(OMIM | 375 | ||
| CHEILITIS GRANULOMATOSA (MELKERSSON–ROSENTHAL SYNDROME) | 375 | ||
| ACUTE NECROTIZING ULCERATIVE GINGIVITIS | 375 | ||
| ORAL PIGMENTATION | 378 | ||
| XEROSTOMIA | 378 | ||
| GINGIVAL HYPERPLASIA | 378 | ||
| SUGGESTED READINGS | 378 | ||
| Chapter 40: Leg Ulcerations | 381 | ||
| PREVALENCE AND ECONOMIC COST | 381 | ||
| PATHOPHYSIOLOGY | 382 | ||
| PATIENT HISTORY AND PHYSICAL EXAMINATION FINDINGS | 387 | ||
| COMMON CAUSES OF ULCERATION | 388 | ||
| DIAGNOSTIC TESTS | 392 | ||
| GENERAL PRINCIPLES OF WOUND CARE | 393 | ||
| LEG ELEVATION. AND COMPRESSION | 398 | ||
| MANAGEMENT OF CHRONIC ULCERATIONS | 399 | ||
| SUGGESTED READINGS | 400 | ||
| Chapter 41: Cutaneous Drug Eruptions | 401 | ||
| DEFINING THE PROBLEM | 401 | ||
| MECHANISMS OF CUTANEOUS DRUG ERUPTION | 401 | ||
| CLINICAL MANIFESTATIONS | 402 | ||
| MAJOR DRUG REACTION PATTERNS | 403 | ||
| DIAGNOSIS | 407 | ||
| LITERATURE RESOURCES | 408 | ||
| MANAGEMENT ISSUES | 409 | ||
| SUGGESTED READINGS | 409 | ||
| Chapter 42: Systemic Therapy for Cutaneous Disease | 411 | ||
| PRINCIPLES OF DRUG SELECTION | 411 | ||
| MONITORING PRINCIPLES | 412 | ||
| SUGGESTED READING | 414 | ||
| Index | 415 |