Menu Expand
Radiology Secrets Plus E-Book

Radiology Secrets Plus E-Book

Drew A. Torigian | Parvati Ramchandani

(2016)

Additional Information

Book Details

Abstract

For 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Radiology Secrets Plus, 4th Edition, by Drs. Drew Torigian and Parvati Ramchandani, features the Secrets’ popular question-and-answer format that also includes lists, tables, and an informal tone – making reference and review quick, easy, and enjoyable.

  • Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams.
  • The proven Secrets® format gives you the most return for your study time – concise, easy to read, engaging, and highly effective.
  • Full-color, expanded layout enhances understanding in this highly visual field.
  • Thorough updates throughout by a new expert author team from the highly regarded program at University of Pennsylvania and world-renowned contributors from top radiology programs.

Table of Contents

Section Title Page Action Price
Front Cover cover
Radiology Secrets Plus i
Copyright Page iv
Dedication v
Contributors vii
Preface xi
Acknowledgment xii
Table Of Contents xiii
Top 100 Radiology Secrets xviii
I Introduction to Imaging Modalities 1
1 Introduction to Radiography, Fluoroscopy, and Tomosynthesis 3
Radiography 3
1. What is radiography? 3
2. When were x-rays discovered? 3
3. How do x-rays differ from other types of electromagnetic radiation? 3
4. How do x-rays interact with matter? 3
5. What is an x-ray tube? 3
6. How are x-rays for diagnostic imaging produced? 3
7. What is a focal spot? 3
8. What is a collimator? 3
9. What happens to most of the energy entering the x-ray tube? 3
10. What key input parameters may be adjusted when generating x-rays? 3
11. What are the effects of increasing kV? 4
12. What are the effects of increasing mAs? 4
13. What is screen film radiography? 4
14. What is computed radiography (CR)? 4
15. What is digital radiography (DR)? 4
16. What is dual energy radiography? 4
17. What is an anti-scatter grid? 4
18. What is the inverse square law? 5
19. What is the difference between a posteroanterior (PA) and an anteroposterior (AP) radiograph? 5
20. What are the five basic densities seen on a radiograph? 5
21. How does mammographic technique differ from that performed in chest and abdominal radiography? 5
Fluoroscopy 5
22. What is fluoroscopy? 5
23. What are some clinical applications of fluoroscopy? 5
24. What general types of contrast agents are used in gastrointestinal fluoroscopic studies? 5
25. What is digital subtraction angiography (DSA)? 5
Tomosynthesis 6
26. What is tomosynthesis, and how does it work? 6
27. What are some clinical applications of tomosynthesis? 6
Bibliography 6
2 Introduction to Ultrasonography, CT, and MRI 8
Ultrasonography (US) 8
1. What is ultrasonography (US), and how does it work? 8
2. When was US first used for clinical diagnostic purposes? 8
3. What are some common clinical applications of US? 8
4. Why is gel used in US? 8
5. What is a transducer, and what types are available for US? 8
6. What is echogenicity? 8
7. What is posterior acoustic enhancement? 8
8. What is posterior acoustic shadowing? 8
9. What is Doppler US? 9
Computed Tomography (CT) 9
10. What is computed tomography (CT), and how does it work? 9
11. When was CT developed? 9
12. What are some common clinical applications of CT? 9
13. What is multislice CT (MSCT)? 9
14. What is dual-source CT (DSCT)? 10
15. What is dual-energy CT (DECT)? 10
16. What is the difference between sequential and helical CT acquisition? 10
17. What is attenuation? 10
Magnetic Resonance Imaging (MRI) 10
18. What is magnetic resonance imaging (MRI), and how does it work? 10
19. When was MRI developed? 11
20. What are some common clinical applications of MRI? 11
21. What are some contraindications to the use of MRI? 11
22. What is the typical field strength of magnets used in clinical MRI? 11
23. What are T1 and T2? 11
24. What is a pulse sequence? 12
25. What is k space? 12
26. What are TR and TE? 12
27. What is a spin echo (SE) pulse sequence? 12
28. What is a fast spin echo (FSE) pulse sequence? 12
29. What is a gradient recalled echo (GRE) pulse sequence? 12
30. What is signal intensity (SI)? 12
31. What are T1-weighted images? 12
32. What are T2-weighted images? 12
33. What typically has high SI on T1-weighted images? 12
34. What typically has high SI on T2-weighted images? 12
35. What typically has low SI on both T1-weighted and T2-weighted images? 13
36. Why is it important to acquire precontrast and postcontrast images with the same imaging parameters? 13
37. What is diffusion-weighted imaging (DWI)? 13
38. What is diffusion-tensor imaging (DTI)? 13
39. What is magnetic resonance spectroscopy (MRS)? 13
Bibliography 13
3 Introduction to Nuclear Medicine and Molecular Imaging 14
1. What is molecular imaging? 14
2. What is nuclear medicine, and how is a nuclear medicine test performed? 14
3. How does molecular imaging differ from structural imaging? 14
4. What is the difference between x-rays used in radiography and CT and gamma rays used in nuclear medicine techniques? 14
5. What is radioactivity, and when was it discovered? 14
6. When was the positron discovered? 14
7. How are radioisotopes and radiotracers created? 14
8. What are some commonly used radioisotopes in diagnostic nuclear medicine? 15
9. What is the physical half-life of a radioisotope? 15
10. What units are used to measure radioactivity? 15
11. What is a dose calibrator? 15
12. How are nuclear medicine imaging tests generally performed? 15
13. What is planar scintigraphy? 16
14. What are some examples of common clinical applications of planar scintigraphy? 16
15. What is SPECT? 16
16. What are some examples of common clinical applications of SPECT/CT? 16
17. What is PET? 16
18. What are some examples of common clinical applications of PET/CT? 17
19. What is a standardized uptake value (SUV)? 18
20. What is total lesional glycolysis (TLG)? 18
21. What is optical imaging, and how does it work? 18
22. What is the difference between fluorescence and bioluminescence? 18
23. What is Cherenkov radiation? 18
Bibliography 18
4 Introduction to Image Processing, Visualization, and Analysis 20
1. What is a digital image? 20
2. What is the difference between a pixel and a voxel? 20
3. What is image reconstruction? 20
4. What is the field of view (FOV) of an image? 20
5. What is the matrix size of an image? 20
6. What is signal-to-noise ratio (SNR)? 20
7. What is contrast-to-noise ratio (CNR)? 20
8. What is spatial resolution? 20
9. What is contrast resolution? 20
10. What is temporal resolution? 20
11. What is a modulation transfer function (MTF)? 20
12. What is quantitative radiology (QR)? 20
13. What is the purpose of computer-aided visualization and analysis (CAVA)? 20
14. What is image preprocessing? 21
15. What is VOI restriction? 21
16. What is filtering? 21
17. What is interpolation? 21
18. What is registration? 21
19. What is segmentation? 21
20. What is thresholding? 21
21. What is the purpose of image visualization? 21
22. What are some ways to visualize tomographic images? 22
23. What is the difference between window level and window width? 23
24. What is the purpose of image manipulation? 23
25. What is the purpose of image analysis? 24
26. What is the purpose of computer-aided diagnosis (CAD)? 24
27. What is a biomarker? 24
28. What is a clinical endpoint? 24
29. What is a surrogate endpoint? 24
30. What is radiomics? 24
31. What is radiogenomics? 24
Bibliography 24
5 Computers in Radiology 26
1. What is PACS? 26
2. How are PACS images stored? 26
3. What is image compression? 26
4. What is the difference between “lossy” and “lossless” compression? 26
5. What is RIS? 26
6. What is HIS? 26
7. What is DICOM? 26
8. What determines image storage size? 26
9. How large are these studies? 27
10. What is teleradiology? 27
11. What is IHE? 27
12. What is HL7? 27
13. How are conventional radiographs integrated into an all-digital PACS? 27
14. What is voice recognition (or speech recognition)? 28
15. What are the advantages and disadvantages of voice or speech recognition relative to conventional dictation/transcription? 28
16. What is structured reporting? 28
17. What is RadLex? 28
18. What is CADe? 28
19. What is BI-RADS? 28
20. What types of injuries can result from working at a PACS workstation, and what are some potential remedies? 28
21. What is image sharing? 29
22. What is XDS? 29
23. What is Imaging 3.0? 29
24. What factors are important to consider when choosing a mobile device for use in radiology departments? 29
25. Can I interpret radiology images on a tablet device? 29
26. What are the display requirements for diagnostic interpretation of radiology images? 30
27. Where can I learn more about imaging informatics? Are there formal training programs and certifications available? 30
Bibliography 31
6 Introduction to Contrast Agents 32
1. What is a radiographic contrast agent? 32
2. What types of contrast agents are available for intravascular use? 32
3. How common are acute adverse reactions to intravascular contrast material? 32
4. What are the categories of acute adverse reaction to contrast agents? 32
5. What are the 5 important immediate assessments that should be made when evaluating a patient for a potential contrast reaction? 33
6. What are some risk factors that predispose patients to acute adverse contrast reactions? 33
7. When do adverse reactions to intravascular iodinated contrast material usually occur? 33
8. What is iodine “mumps”? 33
9. When is premedication indicated prior to contrast administration? 33
10. What is a breakthrough reaction? 34
11. Is there a specific association between presence of a shellfish allergy and an increased allergy to iodinated contrast material? 34
12. Is there a specific association between presence of an allergy to iodinated contrast material and having a future reaction to gadolinium-based contrast material? 34
13. How often does extravasation of intravenous contrast material occur? 34
14. What is the most common severe injury that may occur following extravasation of intravenous contrast material? 34
15. What is contrast-induced nephropathy (CIN)? 34
16. What are the major risk factors for CIN? 34
17. What is the best way to prevent CIN? 34
18. Does metformin increase the risk of CIN? 34
19. Which factors require assessment of patient renal function prior to administration of intravascular contrast material? 35
20. What are the major contraindications to the administration of intravascular contrast material? 35
21. Can intravascular iodinated contrast material be safely administered to anuric patients with end-stage renal disease who are on dialysis? 35
22. What is nephrogenic systemic fibrosis (NSF), and who is at risk for developing this complication? 35
23. Is intravascular iodinated contrast material contraindicated for use in pregnant women? 35
24. Is intravascular gadolinium-based contrast material contraindicated for use in pregnant women? 36
25. Is intravascular contrast material safe for use in women who are breast-feeding? 36
26. What major types of enteric contrast agent are available? 36
27. What are the major complications of barium sulfate enteric contrast material? 36
28. What are the major complications of iodinated contrast material when used as an oral contrast agent? 36
Bibliography 37
7 Radiation Dose and Safety Considerations in Imaging 38
1. What is the terminology for radiation dose? 38
2. In what units is radiation dose expressed? 38
3. What organizations make recommendations or monitor the use of ionizing radiation in medical imaging? 38
4. What are the recommended annual dose limits for radiation exposure? 38
5. What is the ALARA principle? 39
6. What is the inverse square law? 39
7. What are stochastic and nonstochastic effects of radiation exposure? 39
8. What is the BEIR VII report? 39
9. What is the linear no-threshold model? 39
10. What is radiation hormesis? 40
11. What are the biological effects of radiation exposure? 40
12. What are the typical sources and annual levels of background radiation exposure? 40
13. What are the typical levels of radiation exposure caused by various imaging tests? 40
14. What tools are used to measure radiation exposure in diagnostic imaging? 41
15. What is CTDI? 41
16. What is SSDE? 42
17. What is DLP, and how is it calculated? 42
18. What is effective dose, and how is it calculated? 42
19. What approaches are available to reduce exposure to imaging radiation dose? 43
20. What is the American College of Radiology (ACR) Dose Index Registry (DIR)? 43
21. What is Image Wisely? 43
22. What is Image GentlySM? 43
23. What is the Mammography Quality Standards Act (MQSA)? 43
24. What are the risks of radiation to the fetus? 44
25. What types of imaging are permissible in the setting of pregnancy? 45
26. What are the potential safety hazards of US, and how are they avoided? 45
27. How is a radioactive spill managed? 45
28. What are the potential safety hazards of MRI, and how are they avoided? 45
29. What are some contraindications to performing MRI? 45
30. What is specific absorption rate (SAR), and what are the mandated limits? 46
31. What is quenching? 46
Bibliography 46
II Breast Imaging 49
8 Screening Mammography 51
1. What is a screening mammogram? 51
2. When should an average woman start getting mammograms? 51
3. Are there instances when screening should start earlier than 40? 51
4. How many views are obtained for a routine mammogram? 51
5. Which view visualizes the most breast tissue? 51
6. Which portion of the breast is better visualized on the CC view than on the MLO view? 51
7. What if there are comparison studies elsewhere? Do we need to get them? 51
8. What is the incidence of screening-detected breast cancer? 51
9. What is the reported sensitivity of screening mammography? 51
10. What is the difference between a screening mammogram and a diagnostic mammogram? 51
11. Are there other types of breast cancer screening modalities? Which modalities are used in everyday clinical practice? 52
12. Is digital mammography better than film screen mammography in detecting breast cancer? 52
13. Is there an age at which breast cancer screening should stop? 53
14. What are some risk factors for developing breast cancer? 53
15. True or false: Most breast cancers occur in women with a family history of breast cancer. 53
16. True or false: The incidence of breast cancer is currently rising. 53
17. It has been said that one in eight women has a risk of developing breast cancer. Does a 40-year-old woman have the same risk as an 80-year-old woman? 53
18. What are BRCA1 and BRCA2 genes? 53
19. How much radiation does a woman receive from a routine screening mammogram? 53
20. What is the call-back rate? What should the call-back rate be for a radiologist? 53
21. Is the breast a modified skin gland, fatty tissue, muscle, or lymphatic structure? 53
22. How does accessory breast tissue form? Where is it most commonly located? 53
Bibliography 54
9 Diagnostic Mammography 55
1. What are the indications for a diagnostic mammogram? 55
2. What views are performed for diagnostic mammography? How are patients who have undergone diagnostic mammography informed of results? 55
3. What is BI-RADS? 55
4. What types of mammographic changes may be seen after breast conservation? 55
5. Does mammography have high sensitivity in detecting recurrent breast cancer after breast conservation? 55
6. What is the incidence of recurrent breast cancer in a patient after breast conservation? 55
7. True or false: In patients who develop recurrence after breast conservation, survival rates are about the same as for patients who had a mastectomy as the initial treatment. 55
8. What are some contraindications to breast conservation? 55
9. In a patient who is planning to have breast conservation, when is it necessary to obtain a postbiopsy mammogram shortly after a successful excisional biopsy? 56
10. True or false: In a patient with a history of breast cancer, it is beneficial to get a mammogram more frequently than once a year. 56
11. What is a 6-month follow-up? How long is the follow-up performed for BI-RADS category 3 lesions? 56
12. How is the mastectomy bed evaluated? 56
13. What types of surgical reconstruction are available after a mastectomy? 56
14. True or false: After a benign breast biopsy, significant residual changes are usually visible on a mammogram. 56
15. For all breast biopsies, approximately what percentage of the pathology results should be malignant? 56
16. A 47-year-old woman presents with a newly palpable breast mass and has a negative mammogram. What should be done next? 57
17. If US results are negative, what should be done next? What percentage of the time can a cancer be missed on US and mammography? 57
18. What types of nipple discharge are considered suspicious and warrant additional imaging evaluation? What imaging workup is recommended for suspicious nipple discharge? 57
19. What types of nipple discharge are associated with benign etiologies? 57
20. In a patient with a suspicious type of nipple discharge, what is the likelihood that the discharge is due to cancer? 57
21. What is the most common etiology for bloody nipple discharge? 58
22. What are the most common histologic types of breast cancer? 58
23. Is lobular carcinoma in situ (LCIS) a form of cancer? What is the significance of LCIS? 58
24. What is the differential diagnosis for a red swollen breast? 58
25. Is there such a thing as a mammographic emergency? 58
26. How many views are obtained in a patient with breast augmentation? 58
27. Where can the implants be placed in the breast? 58
28. What types of implants are available? 58
29. What is the most sensitive imaging evaluation for implant rupture? 58
30. A man presents with a breast lump. How should the patient be imaged? What is the most common etiology for a breast lump in a man? 59
31. What is the etiology of gynecomastia? 59
32. Do men get breast cancer? What is the frequency? 59
33. True or false: Breast cancer can manifest in the following ways: calcifications, masses, architectural distortion, and density. 59
34. Classify the following terms commonly used to describe breast calcifications as indicative of benign, indeterminate, or malignant patterns. 60
35. Figures 9-4 through 9-9 show images of breast calcifications. Classify them as benign or malignant patterns of calcification. 60
36. What is a triple-negative breast cancer, and what is its significance? 60
37. A patient presents with a palpable breast mass and a stable mammogram. The mass in Figure 9-10 is seen on US. What should be the radiologist’s recommendation? 60
38. What is the difference between multifocal and multicentric breast cancer? 61
39. Are radial scars associated with prior surgery? 61
40. What is a fibroadenoma? 61
41. What is a phylloides tumor? 63
42. What is Mondor’s disease? 63
Bibliography 63
10 Breast Ultrasonography (US) and Breast Procedures 64
1. What are the labeled structures on the ultrasound image in Figure 10-1? 64
2. What type of transducer should be used to perform breast US? 64
3. List the indications for targeted breast US after a mammographic evaluation. 64
4. When would breast US be indicated without obtaining a mammogram first? 64
5. What are some suspicious lesion features for malignancy on US? 65
6. What are some benign lesion features on US? 65
7. What types of biopsy procedures may be performed to evaluate breast lesions? 65
8. What are the relative disadvantages of FNA, core needle biopsy, and needle localization/excision? 65
9. How can one be certain that the lesion of interest was actually what was sampled during core needle biopsy? 66
10. What is the lesion depth, or the z axis, calculated on a stereotactic biopsy? 66
11. In what circumstances would a stereotactic biopsy be difficult to perform? 66
12. In what circumstances would US-guided biopsy be difficult to perform? 66
13. What is a discordant pathology result? 66
14. In what situations or histopathologic diagnoses should an excisional biopsy be recommended after a percutaneous breast biopsy? 66
Bibliography 66
11 Breast MRI 67
1. What are the indications for breast magnetic resonance imaging (MRI)? 67
2. What are the contraindications for breast MRI? 67
3. What are the risks of breast MRI? 67
4. How sensitive is breast MRI at finding breast cancer? 67
5. If a biopsy is performed based on an abnormal MRI finding, how likely will this be cancer? 67
6. What are the typical sequences used in a breast MRI? 67
7. Which is more helpful to characterize a lesion as malignant, morphology on postcontrast images or kinetic analysis features? 67
8. What are the ACR recommended morphologic descriptors for abnormal enhancement on breast MRI? 68
9. What kinds of enhancement kinetics are seen? 68
10. What are the typical morphologic and kinetic features of a benign mass on breast MRI? 68
11. What are some commonly observed benign masses? 68
12. What are the typical features of a malignant mass on breast MRI? 69
13. Are there associated findings that may increase the probability that a breast mass is malignant? 69
14. What are the typical features of malignant nonmass enhancement? 69
15. How should a breast MRI report be organized? 69
16. What are the BI-RADS assessment categories used to indicate management recommendations? 69
17. Does breast MRI have to be performed with contrast material? 72
18. Should breast MRI generally be ordered as a unilateral or bilateral examination? 72
19. What are the next steps after characterizing abnormal enhancement on breast MRI? 73
20. What is MRI-directed US? 73
21. How is breast MRI biopsy performed? 73
22. Is there any recommended follow-up after a benign breast biopsy? 73
23. What are the signs of breast implant rupture? 73
Bibliography 74
III Noninvasive Cardiac and Vascular Imaging 75
12 Cardiac and Pericardiac Imaging 77
1. What forms the borders of the heart on the frontal posteroanterior (PA) or anteroposterior (AP) chest radiograph? 77
2. What forms the borders of the heart on the lateral chest radiograph? 77
3. What are the signs of left atrial enlargement on the chest radiograph? 77
4. What are the signs of right ventricular enlargement on the chest radiograph? 77
5. What is Eisenmenger syndrome? 78
6. What are the advantages of MRI for imaging the heart? 79
7. What are the disadvantages of MRI? 79
8. What are the indications for cardiac MRI? 79
9. What are the contraindications to performing cardiac MRI? 79
10. What are the standard planes for cross-sectional cardiac imaging? 79
11. How is bright blood MRI accomplished, and why is it used? 79
12. How is dark blood MRI accomplished, and why is it used? 80
13. How is cine imaging accomplished, and why is it used? 80
14. How are late gadolinium enhancement (LGE) images obtained, and how are they used? 80
15. What are some diseases that affect valvular function, and how can they be diagnosed with imaging? 80
16. How is phase contrast imaging accomplished, and why is it used? 80
17. Why is Qp/Qs important, and how is it measured on MRI? 82
18. What is the normal imaging appearance of the pericardium? 82
19. What imaging features may be seen with congenital absence of the pericardium? 82
20. What are the imaging findings of a pericardial effusion? 82
21. What are the imaging findings of acute pericarditis? 82
22. What are some imaging findings of chronic (constrictive) pericarditis? 82
23. What portions of the heart are supplied by the right coronary, left anterior descending, and left circumflex arteries? 83
24. What are noninvasive methods of coronary artery imaging? 83
25. What is the most sensitive imaging technique for the detection of myocardial infarction? 83
26. How long after myocardial infarction does a ventricular aneurysm develop? 83
27. How long after myocardial infarction does a ventricular pseudoaneurysm develop? 83
28. What is the differential diagnosis of a regional wall motion abnormality? 84
29. What are some causes of dilated cardiomyopathy and restrictive cardiomyopathy? 84
30. What are the findings of hypertrophic cardiomyopathy on MRI? 85
31. How does a patient with myocarditis present clinically, and what are the findings on MRI? 85
32. In a patient with an abnormal ECG finding and a family history of sudden death, cardiac MRI shows a dilated right ventricle with abnormal wall motion and a normal left ventricle. What is the most likely diagnosis? 85
33. What is myocardial noncompaction, and how does it appear on MRI? 85
34. What happens when a ventricle becomes dilated? 85
35. What are common cardiac or paracardiac masses? 85
36. How can you differentiate tumor from thrombus? 85
37. What is the most common malignancy of the heart and pericardium? 88
38. What does lipomatous hypertrophy of the interatrial septum (LHIS) look like on imaging studies? 88
Bibliography 88
13 Aortic Imaging 90
1. What is the normal imaging appearance of the aorta on computed tomography (CT) and magnetic resonance imaging (MRI)? 90
2. What typical CT and MRI protocols/techniques are used to image the aorta? 90
3. What are aneurysms and pseudoaneurysms, and how do they differ? 91
4. What is a mycotic aneurysm? Which imaging findings help suggest the diagnosis? 91
5. What is an inflammatory abdominal aortic aneurysm (AAA)? 91
6. What are aortoenteric and aortocaval fistulas, and how are they diagnosed? 91
7. What is an aortic dissection, and how is it different from aortic transection? 91
8. In the setting of blunt trauma, where do aortic injuries most commonly occur? 92
9. How are traumatic aortic injuries diagnosed? 92
10. Name the chest radiographic findings that are suggestive of thoracic aortic pathology. 92
11. What are the two classification schemes for aortic dissection? 92
12. How are dissections that involve the ascending aorta managed differently from those that involve the descending aorta only? 93
13. Which lumen is usually larger in aortic dissection—the true or false lumen? 93
14. Describe other acute aortic syndromes that are often called variants of aortic dissection. 93
15. What is the best imaging modality for diagnosing each of these conditions? 93
16. How can these conditions be distinguished on axial CT or MR images? 94
17. What is the utility of precontrast imaging when performing CTA or MRA of the aorta? 94
18. How large must the thoracic and abdominal aortas be to be called aneurysmal? 94
19. When is an AAA usually repaired? 94
20. What is Laplace’s law, and how is it relevant to aortic aneurysms? 94
21. Can the overall size of an aortic aneurysm be determined by catheter angiography? 94
22. How is the size of the aorta most accurately measured on CT or MRI? 94
23. Name two methods of repairing aneurysms, and compare their advantages and disadvantages. 95
24. What criteria are used to determine whether an aortic aneurysm can be treated by endovascular technique? 95
25. Why is follow-up imaging of stent-grafts needed? 95
26. What is the expected CT and MR imaging appearance of the aorta after stent-graft repair? 95
27. What are endoleaks, and what imaging technique is used to find them? 96
28. What other types of aortic procedures can be performed through an endovascular approach? 96
29. How do aortic coarctation and pseudocoarctation differ? 96
30. What measurements are required for planning of transcatheter aortic valve replacement (TAVR)? 96
31. What is a bovine aortic arch? 98
Bibliography 98
14 Coronary Arterial Imaging 99
1. What are some noninvasive methods of coronary artery imaging? 99
2. What is coronary CTA, and how does it differ from routine chest CT? 99
3. How long does a cardiac CT acquisition take? 99
4. What is gating? 99
5. Can coronary CT imaging be performed at any heart rate? 99
6. What are the indications for CT coronary calcium scoring, and how is it performed? 101
7. What is the diagnostic performance of CT coronary calcium scoring? 101
8. What are the indications, contraindications, typical scanning protocols, advantages, and disadvantages for coronary CTA versus magnetic resonance angiography (MRA)? Which patients can benefit from coronary CTA? 101
9. What is the normal CT and MR imaging appearance of the coronary arteries? 101
10. What is the normal coronary arterial anatomy, and what is the frequency and significance of anatomic variants? 102
11. Can I use nitroglycerin to dilate the coronary arteries and obtain better images? 102
12. How much radiation exposure is there for a patient undergoing coronary CTA? 102
13. What are the advantages and disadvantages of coronary CTA versus catheter angiography? 102
14. Can I use coronary CTA as a single study for a patient with chest pain to exclude cardiac ischemia, aortic dissection, and pulmonary embolus? 102
15. Are there uses for cardiac CT other than coronary artery evaluation? 102
16. How is a coronary CTA examination reviewed? 105
17. How are coronary artery stenoses reported? 105
18. What are the CT and MR imaging (and relevant clinical) features of some common coronary arterial pathologies? 105
19. Which congenital coronary artery anomalies can cause sudden death? 105
20. What is the usefulness of CT in imaging atherosclerosis? 106
21. What is myocardial bridging, and is it important? 106
22. What is a coronary artery aneurysm? 106
23. What are the CT and MR imaging features of coronary arterial stents and bypass grafts (including various types)? 107
24. Have clinical trials shown an advantage to using coronary CTA in place of catheter angiograms or nuclear stress tests? 107
Bibliography 108
15 Pulmonary Vascular Imaging 109
1. What is the normal appearance of the pulmonary vessels on computed tomography (CT) and magnetic resonance imaging (MRI)? 109
2. What are the indications for computed tomography angiography (CTA) versus magnetic resonance angiography (MRA) for pulmonary vascular imaging? 109
3. What are the typical CTA and MRA pulmonary vascular imaging protocols? 109
4. What is the role of chest radiography in the diagnosis of pulmonary embolism (PE)? 109
5. What are advantages of CTA for assessment of PE? 109
6. What are the direct CTA findings of PE? 110
7. What are the indirect CTA findings of PE? 110
8. How can acute PE be distinguished from chronic PE on CTA? 110
9. What are other uses for CT in the setting of PE? 110
10. What is pulmonary hypertension, and what CT and MRI findings are suggestive? 110
11. What is a pulmonary artery aneurysm, and what is the major differential diagnosis? 112
12. What is a pulmonary AVM, and what is the clinical presentation? 112
13. With what hereditary disorder are pulmonary AVMs associated? 112
14. You are asked to start a peripheral intravenous line in a patient with a known pulmonary AVM. What special precautions should you take? 112
15. What are the imaging characteristics of a pulmonary AVM on radiography, CT, and MRI? 112
16. What is partial anomalous pulmonary venous return (PAPVR)? 112
17. What is scimitar syndrome, and what are its associated imaging findings? 112
18. What is the most common primary neoplasm of the pulmonary artery? 114
Bibliography 114
16 CT Angiography and MR Angiography of the Peripheral and Visceral Vasculature 115
1. What are the clinical indications for computed tomography angiography (CTA) and magnetic resonance angiography (MRA) of the peripheral and visceral arteries? 115
2. What is the most important principle for performing contrast-enhanced CTA and MRA? 115
3. How is the image acquisition timed following contrast administration in a CTA? 115
4. When should a test bolus be used? 115
5. Describe a typical computed tomography (CT) protocol for assessing the arteries. 115
6. Is the quality of evaluation of the arteries of the lower extremities better with a wide-detector multidetector row CT (MDCT) scanner? 116
7. How can we mitigate outrunning of the contrast bolus when using a wide-detector MDCT scanner? 116
8. What is the most important consideration when imaging the arteries of the upper extremities? 116
9. How is MRA image acquisition timed? 116
10. Describe a typical MRA protocol. 116
11. What are the options if the patient cannot receive intravenous gadolinium-based or iodinated contrast material? 116
12. What must you tell the MRI technologists when performing a TOF MRA? 116
13. What is the advantage of TOF MRA? 117
14. What are the disadvantages of TOF MRA? 117
15. Is CTA or contrast-enhanced MRA better? 117
16. When performing a contrast-enhanced MRA, what must you communicate to the technologists? 117
17. Is CTA or MRA preferred for assessment of the renal arteries? 117
18. Is CTA or MRA preferred for assessment of the iliac arteries for percutaneous access? 117
19. Is CTA or MRA preferred for assessment of the calf and foot vessels? 117
20. Is CTA or MRA preferred for assessment of arteriovenous malformations? 117
21. Is CTA or MRA preferred for assessment of mesenteric ischemia? 117
22. Is CTA or MRA preferred for assessment of arterial trauma following penetrating trauma? 118
23. Is CTA or MRA preferred for assessment of endoleaks following stent graft repair of an aneurysm? 118
24. Is CTA or MRA preferred for assessment of entrapment syndromes? 118
25. Is CTA or MRA preferred for assessment of venous thrombosis? 118
26. How are CT and MR angiographic images visualized? 118
27. What is a hemodynamically significant artery stenosis? 118
28. How do we measure stenosis? 118
29. What are the major branches of the celiac artery, superior mesenteric artery (SMA), and inferior mesenteric artery (IMA)? 118
30. What is the most common variant of the celiac axis? 118
31. What are the major collateral pathways in the abdomen? 119
32. What is the meandering mesenteric artery? 119
33. What artery is often occluded during open or endovascular repair of an AAA? 119
34. Why are angiographic studies performed on potential renal donors? 119
35. What is the prevalence of accessory renal arteries in the general population? 120
36. What is the most common left renal vein anatomic variant? 120
37. What are the major normal variants of the IVC? 120
38. What segment is missing in azygos continuation of the IVC? 120
39. What anatomic structure is used as a reference for the parts of the subclavian artery? 120
40. At what point does the subclavian artery become the axillary artery? 121
41. What are the major branches of the upper extremity arterial tree? 121
42. What structures separate the superficial femoral artery (SFA) from the popliteal artery and the external iliac artery from the common femoral artery (CFA)? 121
43. On an anterior projection, which thigh vessel takes a more medial course: the SFA or the deep femoral (profunda femoris) artery (DFA)? 121
44. What is meant by “single-vessel,” “two-vessel,” or “three-vessel” runoff? 121
45. What is the distribution of peripheral vascular disease in different age groups? 121
46. What compressive disorders may involve the popliteal artery? 122
47. How does one assess for popliteal entrapment syndrome? 122
48. What are the causes of venous contamination? 122
49. A 40-year-old heavy smoker has pain in the foot at rest. Should one be thinking about atherosclerosis as the underlying etiology? 122
50. How may renal arterial steno-occlusive disease present clinically? 123
51. What are the common causes of renal artery stenosis? 123
52. What are the common causes of renal artery aneurysms/pseudoaneurysms? 124
53. What are the common causes of renal artery dissection? 124
54. How is FMD classified? 124
55. How does FMD present? 124
56. Does a normal CTA or MRA exclude presence of polyarteritis nodosa (PAN)? 125
57. What is the median arcuate ligament, and what is its significance? 125
58. Can ostial celiac artery or SMA occlusion result in mesenteric ischemia? 125
59. What is SMA syndrome? 125
60. What is nutcracker syndrome? 125
61. Which vein is compressed in May-Thurner syndrome? 125
62. Is CT or MRI the preferred imaging modality to assess for acute lower extremity deep vein thrombosis (DVT)? 125
63. What is pelvic congestion syndrome? 126
64. How do patients with thoracic outlet syndrome (TOS) present? 126
65. List some useful tips regarding imaging assessment of patients with suspected TOS. 127
66. Is CTA or MRA better to assess for subclavian steal syndrome? 127
67. List some principles regarding CTA and MRA assessment of the vasculature of a transplanted kidney. 127
68. What is the main clinical indication for pancreatic transplantation? 127
69. What is the vascular anatomy of the pancreatic transplant? 128
Bibliography 128
IV Thoracic Imaging 131
17 Imaging of Lung Nodules and Masses 133
1. What is a solitary pulmonary nodule (SPN)? 133
2. List some causes of pulmonary nodules. 133
3. What is the general approach to the evaluation of SPN? 133
4. What further diagnostic steps may be implemented in the workup of indeterminate pulmonary nodules? 133
5. What are the Fleischner Society guidelines? 133
6. What are some potential blind spots on chest radiography and CT when trying to detect pulmonary nodules? 133
7. List some morphologic imaging features of nodules assessed on CT. 133
8. Describe morphologic imaging findings that are suggestive of a benign SPN. 134
9. Describe morphologic imaging findings that are suggestive of a malignant SPN. 134
10. How does measurement of the doubling time of nodules aid in the determination of a benign SPN? 136
11. How does the degree of enhancement of pulmonary nodules on CT aid in the determination of benignancy? 136
12. How does FDG PET aid in the differentiation of benign and malignant lung nodules? 136
13. Describe some clinical features that suggest whether SPN is more likely to be malignant and whether it is more likely to be due to lung cancer or a pulmonary metastasis. 136
14. What minimally invasive procedures may be used to obtain tissue samples from SPN? 137
15. What are the potential complications of transthoracic needle biopsy? 137
16. How important is lung cancer as a public health issue? 137
17. What are the major histologic types and subtypes of lung cancer? 137
18. Summarize some of the different features of the various histologic types and subtypes of lung cancer. 137
19. What is a superior sulcus tumor? 137
20. Describe the major imaging findings related to lung cancer. 137
21. Summarize the American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) staging system for lung cancer. 139
22. Are there any other staging systems used in patients with SCLC? 139
23. When is NSCLC generally considered unresectable? 139
24. Are there any reliable screening tests for lung cancer? What is the National Lung Screening Trial (NLST)? 140
25. Are there any risks of LDCT screening for lung cancer? 140
26. Name some treatment options for lung cancer. 140
27. Describe the imaging findings of pulmonary metastases. 140
28. What is lymphangitic carcinomatosis? 140
29. What are pulmonary carcinoid tumors? 140
30. What is a pulmonary hamartoma? 141
31. What is congenital bronchial atresia? 141
Bibliography 141
18 Imaging of Airspace Lung Disease 143
1. What is the difference between a pulmonary acinus and a secondary pulmonary lobule? 143
2. When a patient is suspected of having airspace lung disease, what is the first imaging method of evaluation that is utilized? 143
3. When is chest CT used to assess airspace lung disease? 143
4. True or false: Referring to an “opacity” on chest radiography or CT implies airspace disease. 143
5. What is the definition of consolidation? 143
6. What is the “silhouette” sign? 143
7. What is an air bronchogram? 143
8. What is the difference between an acinar opacity and an air alveologram? 143
9. What is the definition of ground glass opacity? 143
10. What is the crazy paving pattern? 145
11. What are centrilobular nodules and tree-in-bud opacities? 145
12. True or false: Consolidation and ground glass opacities indicate pneumonia. 146
13. True or false: Consolidation and ground glass opacity can be seen in acute and chronic conditions. 146
14. What are some causes of acute airspace disease? 146
15. What are some causes of chronic airspace disease? 146
16. What are some causes of diffuse airspace disease? 146
17. What are some causes of multifocal or patchy airspace disease? 146
18. What are some causes of focal airspace disease? 146
19. What are some causes of peripheral airspace disease? 146
20. What is atelectasis? 146
21. What types of atelectasis may occur? 146
22. What are the imaging features of atelectasis? 147
23. What is rounded atelectasis, and what is the “comet tail” sign? 147
24. What is the “Luftsichel” sign? 147
25. What is the “juxtaphrenic peak” sign? 147
26. What is the “S sign of Golden”? 147
27. What is right middle lobe syndrome? 148
28. What are the different types of pulmonary edema, and what are some common causes of each? 148
29. True or false: A normal sized heart on a chest radiograph excludes the presence of pulmonary edema. 149
30. True or false: The radiographic appearance of hydrostatic pulmonary edema correlates well with left atrial pressures. 149
31. What is cephalization? 149
32. What is alveolar edema? 149
33. What is “bat wing” pulmonary edema, and is this the most common radiographic pattern of pulmonary edema? 149
34. True or false: Pleural effusions can be unilateral in congestive heart failure. 149
35. True or false: Pulmonary edema can be unilateral. 149
36. How does pulmonary edema appear on CT? 149
37. What are the definitions of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)? 149
38. What are the pathophysiological phases of ARDS, and how do these manifest on imaging? 150
39. True or false: Causes of ARDS can be intrathoracic or extrathoracic, and this distinction can be inferred on CT imaging. 151
40. What are some chronic CT findings of ARDS? 151
41. What is aspiration, what are some of its common underlying causes, and what is its radiographic appearance? 151
42. What is pneumonia, and what are some of its associated complications? 151
43. What are some clinical questions one may ask the referring physician when evaluating imaging studies in a patient with suspected pneumonia? 151
44. What are the common causes and imaging appearances of: Bacterial pneumonia? Viral pneumonias? Fungal pneumonias? Mycobacterial pneumonias? Pneumocystis pneumonia? 152
45. In the setting of pulmonary consolidation, what are some additional CT findings that are helpful to predict whether the underlying etiology is infectious or noninfectious? 152
46. True or false: Cavitation is a nonspecific imaging feature. 152
47. What are some common infections that cavitate? 153
48. What are the “halo” and “air crescent” signs, and what infection is classically associated with these signs? 153
49. What is a fungus ball, and if it is suspected, what imaging-based maneuver can be performed to confirm the suspicion? 154
50. What is the “Monad” sign? 155
51. What is allergic bronchopulmonary aspergillosis (ABPA)? 155
52. What is a bronchocele, and what is the “finger-in-glove” sign? 155
53. What is the radiographic appearance of primary TB? 155
54. What is a Ghon complex, a Ghon focus, and a Ranke complex, and how do these appear on imaging? 155
55. What are the imaging findings associated with postprimary (reactivation) TB? 156
56. True or false: A miliary appearance on imaging is specific for TB. 156
57. True or false: Typical (TB) and atypical mycobacterial infections are easily distinguished on imaging. 156
58. What is Lady Windermere syndrome? 156
59. What infectious organism(s) should you suspect in the setting of: HIV infection and perihilar ground glass opacities on CT? Heart transplantation and a solitary cavitary mass? Chest wall invasion? 156
60. What are the pulmonary manifestations of drug toxicity on imaging? 156
61. What drug can result in high attenuation pulmonary consolidation on CT? 156
62. What drug used to treat patients with acute myelogenous leukemia can result in pulmonary hemorrhage? 157
63. What is diffuse alveolar hemorrhage (DAH), and what is its imaging appearance? 157
64. What disease condition should you consider to be present in a patient with renal failure, sinonasal disease, and pulmonary alveolar hemorrhage? 157
65. What is the imaging appearance of pulmonary contusions and lacerations? 157
66. What is pulmonary alveolar proteinosis (PAP), and what is the difference between primary and secondary PAP? 157
67. What is the classic CT appearance of PAP? 158
68. What entity can result in fat (or near fat) low attenuation pulmonary opacities on CT? 158
69. What is organizing pneumonia, and what are some common causes? 158
70. What is meant by the term cryptogenic organizing pneumonia (COP), and what are its imaging features? 158
71. What is the “reversed halo” sign or “atoll” sign? 158
72. How can one distinguish between chronic eosinophilic pneumonia and COP on imaging? 158
73. What should one clinically suspect in a patient with persistent pulmonary consolidation and bronchorrhea? 159
Bibliography 159
19 Radiography of Interstitial Lung Disease 160
1. What radiographic features distinguish interstitial diseases from airspace diseases? 160
2. What factors influence the likelihood of one interstitial disease over another interstitial disease? 160
3. What is the most common interstitial abnormality identified on chest radiography? 160
4. Name the most common interstitial abnormalities other than interstitial pulmonary edema. 160
5. What radiographic characteristics help determine the diagnosis of interstitial disorders? 161
6. What is the appearance of a nodular interstitial pattern on chest radiography? 161
7. What disorders cause nodular interstitial diseases? 161
8. Discuss granulomatous lung diseases that cause nodular interstitial disease. 161
9. Discuss pneumoconioses and tumors that lead to nodular interstitial lung disease. 161
10. Discuss the smoking-related lung diseases that cause micronodular lung disease. 162
11. What is the chest radiographic staging system for sarcoidosis, and what is the clinical significance? 162
12. Give some examples of hypersensitivity pneumonitis (extrinsic allergic alveolitis). 162
13. Why do intravenous drug abusers get talcosis? 162
14. What radiographic feature of nodular pneumoconioses is most strongly associated with respiratory deficits? 163
15. What are the radiographic characteristics of the peripheral reticular pattern? 163
16. Which diseases cause the peripheral reticular pattern? 163
17. What demographic features can help distinguish the cause of the peripheral reticular pattern? 163
18. Which connective tissue disorders can result in interstitial disease? 164
19. Are there any imaging features that can help distinguish the cause of the peripheral reticular pattern? 164
20. Describe the imaging characteristics of the linear pattern on chest radiography. 165
21. What disorders cause the linear pattern of interstitial disease? 165
22. Are there any imaging clues that may help to distinguish the cause of the linear interstitial pattern? 166
23. What are the imaging characteristics of the cystic pattern of interstitial lung disease? 167
24. What disorders produce the cystic interstitial pattern? 167
25. What disorders cause diffuse bronchiectasis? 167
26. Are there any radiographic imaging features that help to distinguish the cause of the cystic pattern? 168
27. When is computed tomography (CT) scanning indicated for the evaluation of interstitial lung disease? 168
28. What type of CT scan is indicated for the evaluation of interstitial lung disease? 168
Bibliography 169
20 Imaging of Mediastinal Disease 170
1. Describe the anatomy of the mediastinum. 170
2. What are the three compartments of the mediastinum? 170
3. List the differential diagnosis of major anterior mediastinal lesions. 170
4. List the differential diagnosis of major middle mediastinal lesions. 170
5. List the differential diagnosis of major posterior mediastinal lesions. 172
6. List the differential diagnosis of fat-containing mediastinal lesions. 172
7. List the differential diagnosis of cystic mediastinal lesions. 172
8. Name different collections that may occur within the mediastinum. 172
9. What clinical symptoms and signs can be associated with mediastinal lesions? 172
10. What is a thymoma? 172
11. Describe the clinical presentation of a thymoma. 172
12. Describe the imaging findings of a thymoma. 173
13. What is thymic carcinoma? 173
14. What is thymic carcinoid? 173
15. What is thymolipoma? 174
16. What is a mediastinal germ cell tumor? 174
17. What is a mediastinal teratoma? 174
18. Name a rare but highly specific clinical presentation of mediastinal teratoma. 175
19. What is mediastinal thyroid goiter? 175
20. Define mediastinal lipoma and mediastinal lipomatosis. 175
21. What is Hodgkin lymphoma (HL)? 175
22. What is non-Hodgkin lymphoma (NHL)? 176
23. What are the most common causes of mediastinal lymphadenopathy? 176
24. Which vascular disorders can appear as mediastinal masses? 176
25. Describe the congenital foregut cysts. 176
26. What is a mediastinal pancreatic pseudocyst? 177
27. What is pneumomediastinum? 177
28. What is acute mediastinitis? 178
29. Describe the imaging features of acute mediastinitis. 178
30. What is a mediastinal abscess? 178
31. What is fibrosing mediastinitis? 178
32. What are neurogenic tumors? 178
33. Describe the imaging appearance of neurogenic tumors. 178
34. What is an intrathoracic meningocele? 179
35. How do osseous tumors and infection within the posterior mediastinum differ on imaging? 179
36. What is extramedullary hematopoiesis? 179
Bibliography 179
21 Imaging of Pleural Disease 181
1. Describe the normal pleural anatomy and physiologic features. 181
2. List the major tumors that may affect the pleura. 181
3. What are the major substances that may collect within the pleural space? 181
4. What is the differential diagnosis of major causes of pleural effusion? 181
5. List the major mechanisms of pleural effusion formation. 182
6. What are the two major types of pleural effusions? 182
7. What are the major imaging findings of simple nonloculated pleural effusions on upright chest radiography? 182
8. Describe the major imaging findings related to simple nonloculated pleural effusions on portable supine and semi-upright chest radiography, computed tomography (CT), and magnetic resonance imaging (MRI). 182
9. What are the major imaging findings associated with complex loculated pleural effusions? 183
10. List the differential diagnosis of major causes of hemothorax. 183
11. What is pneumothorax? 183
12. What are the radiographic imaging findings of pneumothorax? 183
13. How much gas in a pneumothorax is required for radiographic visualization? 183
14. What radiographic maneuvers can be performed to show a subtle pneumothorax? 183
15. What is a tension pneumothorax? 184
16. What is the differential diagnosis of major causes of pneumothorax? 184
17. When should treatment of a patient with a pneumothorax be considered? 184
18. How is the diagnosis of an empyema obtained? 184
19. When is empyema usually treated? 185
20. What is empyema necessitatis? 185
21. List causes of pleural calcification. 185
22. What are pleural plaques? 185
23. What is malignant pleural mesothelioma? 185
24. What are risk factors for the development of malignant pleural mesothelioma? 185
25. Describe symptoms and signs of malignant pleural mesothelioma. 185
26. What are the imaging findings of malignant pleural mesothelioma? 186
27. What diagnostic tests may be used in the diagnosis or staging of malignant pleural mesothelioma? 186
28. What is the prognosis for malignant pleural mesothelioma? 187
29. Describe the general treatment approach to malignant pleural mesothelioma. 187
30. What is solitary fibrous tumor of the pleura? 187
31. Name clinical presentations of solitary fibrous tumor of the pleura. 187
32. What are the imaging features of solitary fibrous tumor of the pleura? 187
33. What is the treatment for solitary fibrous tumor of the pleura? 188
Bibliography 188
22 Tubes, Lines, Catheters, and Other Devices 189
1. What is the radiographic appearance of an endotracheal tube (ETT), and where is it optimally placed? 189
2. Describe how an ETT may be malpositioned; list other potential complications of ETT placement. 189
3. What is the optimal positioning of a tracheostomy tube? 189
4. Name potential complications after tracheostomy tube placement. 189
5. What is the radiographic appearance and ideal positioning of a nasogastric tube (NGT) or orogastric tube (OGT)? 189
6. Describe the radiographic appearance and optimal location of an enteral feeding tube. 189
7. Discuss ways in which an NGT, OGT, or feeding tube may be malpositioned, including other potential complications. 190
8. If an NGT, OGT, or feeding tube is misplaced within the tracheobronchial tree, what should one do before removing the tube? 192
9. When is a thoracostomy tube generally used? 192
10. What is the radiographic appearance of a thoracostomy tube, and where should its tip be located? 192
11. Discuss potential complications of thoracostomy tube placement. 192
12. How can I decrease the chance of injury to an intercostal artery or vein during thoracostomy tube placement? 192
13. Describe the basic normal venous anatomy of the chest. 193
14. What is the radiographic appearance and optimal location of a central venous line (CVL) and a peripherally inserted central catheter (PICC)? 193
15. What are potential complications of CVL or PICC placement? 193
16. List locations where a CVL or PICC may be malpositioned when inserted through a vein. 194
17. Name some clues of inadvertent arterial puncture with a CVL, PICC, or Swan-Ganz catheter (SGC). 194
18. What should one consider in the differential diagnosis for rapid development of an ipsilateral pleural effusion or mediastinal widening after CVL, PICC, or SGC placement? 194
19. If air embolism is suspected during catheter placement, what should one do to treat the patient? 195
20. How do I prevent air embolism during catheter placement in the first place? 195
21. Describe the radiographic appearance of an SGC and its optimal location. 195
22. What are potential complications of SGC placement? 195
23. Why can pulmonary infarction occur as a complication of SGC placement? 195
24. How does an intraaortic counterpulsation balloon (IACB) work? 195
25. What are the major indications and contraindications for placement of IACB? 196
26. Describe the radiographic appearance of an IACB and its optimal position. 196
27. What are the potential complications of IACB? 196
28. What is the radiographic appearance of a transvenous pacemaker or automatic implantable cardioverter defibrillator (AICD)? 197
29. Where should the leads of a transvenous pacemaker or AICD be located? 197
30. What are potential complications of transvenous pacemaker/AICD placement? 197
31. What is twiddler’s syndrome? 197
32. Name two retained foreign bodies that may be encountered in the postoperative setting. 197
33. What are some procedure types and risk factors that may increase the risk of retention of a surgical foreign body? 198
34. What are the potential complications of retained foreign bodies? 199
Bibliography 200
V Gastrointestinal Imaging 201
23 Abdominal Radiography 203
1. What is a “flat plate” of the abdomen? 203
2. What structures are visible on a plain abdominal radiograph? 203
3. What is an anteroposterior radiograph? 204
4. What is a lateral decubitus radiograph? 204
5. What is the purpose of an image obtained with the patient in a lateral decubitus or erect position? 204
6. List indications for obtaining a plain radiograph of the abdomen. 205
7. What are the advantages and disadvantages of a plain abdominal radiograph versus a computed tomography (CT) scan? 205
8. In the era of fast CT scanners, what is the role of a plain radiograph? 205
9. Why is the term free air a misnomer? 205
10.\tWhat are the best patient positions to detect free intraperitoneal gas on a plain radiograph? 205
11. What percentage of supine radiographs shows free intraperitoneal gas? 205
12. What is the “Rigler” sign? 205
13. In what abdominal quadrant is free intraperitoneal gas best detected? 206
14. A coned-down image of the abdominal right upper quadrant is presented in Figure 23-7. What structure is outlined by gas, and where is the gas located? 206
15. What is the most common non-iatrogenic cause of pneumobilia? 206
16. What is the Rigler triad? 207
17. What does the linear form of pneumatosis imply? 207
18. In what portions of the GI tract is normal gas located when the patient is radiographed in supine and prone positions? 209
19. What does the term ileus mean? 209
20. Which study is superior in diagnosing small bowel obstruction: plain radiograph or CT? 209
21. What are the pitfalls of plain radiographic diagnosis of small bowel obstruction? 209
22. What imaging modality is able to diagnose a bowel obstruction complicated by ischemia? 210
23. Can CT show adhesions? 210
24. In what situations are barium studies most helpful for the diagnosis of small bowel obstruction? 210
25. What is the most common form of colonic volvulus? 210
26. What patient groups have a greater incidence of sigmoid volvulus? 210
27. What is wrong with the term cecal volvulus? 210
28. What percentage of gallstones is calcified? 212
29. A plain radiograph of the abdomen is obtained in a patient who has a palpable abdominal mass (Figure 23-18). What is the diagnosis? 212
30. A coned-down view of the upper abdomen (Figure 23-20) is obtained in a man with chronic abdominal pain. What is the diagnosis? 214
31. A patient has a palpable abdominal mass (Figure 23-22). What organ is enlarged? 214
32. A 45-year-old man has recently received a liver transplant. Identify the type and location of the two tubular structures below the diaphragm in Figure 23-23, A. What has the radiologist done in Figures 23-23, B and C? 215
33. A 38-year-old man complains of nausea and vomiting (Figure 23-24). What type of tube has been placed in Figure 23-24, A? 216
Bibliography 216
24 Fluoroscopy of the Upper Gastrointestinal Tract 217
1. What organs are studied during an upper gastrointestinal (GI) series? 217
2. What organs are studied during a pharyngoesophagogram? 217
3. What organ is shown in Figure 24-1? 217
4. What organs are shown in Figure 24-2? Identify the numbered parts of the organs as labeled, along with the curvatures labeled by arrows. 217
5. Why does the gastric fundus appear white in Figure 24-2, whereas the gastric antrum appears gray? 217
6. Two images of the esophagus are presented in Figure 24-3. What is your diagnosis? 217
7. What does “single contrast” mean? 219
8. What does “double contrast” mean? 219
9. What are clinical indications for performing an upper GI study? 219
10. What are clinical indications for performing a video/DVD pharyngoesophagogram? 219
11. A 23-year-old woman complains of a lump in her throat at all times of the day (a globus sensation). An image of the lower pharynx and upper cervical esophagus is obtained (Figure 24-6). What is your diagnosis? 220
12. A 74-year-old man complains of a lump in his throat and regurgitation of food into his mouth. Images of the lower pharynx and upper cervical esophagus are obtained (Figure 24-7). What is your diagnosis? 221
13. Describe the preparation for an upper GI study or pharyngoesophagogram. 221
14. What are contraindications to a barium study of the upper GI tract? 222
15. What type of contrast agent should be requested first in patients with suspected upper GI perforation? 222
16. When is a single-contrast upper GI series performed? 222
17. What portion of the GI tract is shown in Figure 24-8? 222
18. What portion of the GI tract is shown in Figure 24-9? 222
19. What are the indications for a small bowel follow-through? 223
20. Figure 24-10 is an overhead image obtained from what type of study? What organ is being imaged? 223
21. What layers of the bowel wall comprise the valvulae conniventes? 223
22. What are the indications for enteroclysis (small bowel enema)? 223
23. What is the preparation for enteroclysis? 224
24. Figure 24-11 is a spot radiograph of the terminal ileum in a young man with chronic diarrhea. What disease does this patient have? 224
25. Figure 24-12 is from a double-contrast esophagogram performed in an immunocompromised patient with acute odynophagia. What is your diagnosis? 224
26. Figure 24-13 is an image performed during an esophagogram while the patient lies prone and rapidly drinks thin barium. This patient had long-standing dysphagia for solids and chronic heartburn. What is your diagnosis? 224
27. Figure 24-14 is an image performed during an esophagram in another patient with long-standing dysphagia. What is your diagnosis? 225
28. Figure 24-15 shows two images of the lesser curvature of the stomach from a double-contrast upper GI series performed in a young patient with 1 week of abdominal pain. What is your diagnosis? 225
29. Figure 24-16 is an image of the gastric antrum from a double-contrast upper GI series performed in a 52-year-old woman with anemia. What is your diagnosis? 227
30. Figure 24-17 is a close-up of the distal greater curvature of the stomach obtained during a double-contrast upper GI series performed in a patient with abdominal pain and rheumatoid arthritis. What is your diagnosis? 227
31. A coned-down image of the gastric fundus obtained during a double-contrast upper GI series is shown in Figure 24-18. What is your diagnosis? 227
32. A coned-down image of the gastric fundus obtained during a double-contrast upper GI series is shown in Figure 24-19. What is your diagnosis? 227
33. Figure 24-20 is an image of the gastric antrum from a double-contrast upper GI series performed in a 43-year-old man with anemia. What is your diagnosis? 227
34. An elderly man complains of early satiety. A spot radiograph of the stomach from a double-contrast upper GI series is provided (Figure 24-21). What is your diagnosis? 229
35. Figure 24-22 is a spot radiograph of the lower stomach obtained from a double-contrast upper GI series in a man who has had 4 months of abdominal discomfort. What is your differential diagnosis? 229
36. A young man complains of acute right upper quadrant pain. Figure 24-23 is a spot radiograph from a double-contrast upper GI series. What is your diagnosis? 230
37. Figure 24-24, A, is a coned-down image of the mid–small bowel obtained in a man with unexplained heme-positive stool. Figure 24-24, B, is an axial image from a CT scan that was performed several days later. What is your differential diagnosis? 230
38. What is the best radiologic test to show small bowel tumors? 230
39. A young man complains of increasing abdominal distention and subacute right lower quadrant pain. Two images from a computed tomography (CT) scan are presented (Figure 24-26). Although a specific diagnosis is not possible, describe what is happening. 231
40. A young man complains of diarrhea for 4 weeks. Figure 24-27 is a spot image of the terminal ileum from a small bowel follow-through. What is your diagnosis? 231
41. A patient with known Crohn’s disease comes to the emergency department with abdominal pain (Figure 24-28). What radiologic test should be performed first? 233
42. A middle-aged woman has peripheral lymphadenopathy and heme-positive stool. Figure 24-29 is an image of the terminal ileum and ileocecal valve from the single-contrast phase of a small bowel enema. What are the diagnostic possibilities? 233
43. A middle-aged woman has foul-smelling yellow stools. Figure 24-30 is a spot image of the proximal jejunum obtained during enteroclysis. The double arrows represent 1 inch. What is your diagnosis? 233
44. A 35-year-old woman has right lower quadrant pain and diarrhea. The results of the CT scan were normal. Figure 24-31 is a spot radiograph of the distal ileum from a small bowel follow-through. What is your diagnosis? 233
45. A 44-year-old man had surgery for a persistent duodenal ulcer (Figure 24-32). What operation was performed? 233
46. What are the physiologic sequelae of gastric operations? 234
47. A 62-year-old man complains of abdominal pain 20 years after an antrectomy with gastroduodenostomy was performed for intractable duodenal ulcer disease (Figure 24-33). What is your differential diagnosis? 235
48. A 45-year-old woman complains of vomiting. She had surgery for morbid obesity 2 years previously (Figure 24-34). What operation did this patient have? Why is she vomiting? 235
49. A 42-year-old woman has undergone surgery for morbid obesity (Figure 24-35). What operation was performed? 236
50. A 41-year-old woman had undergone surgery for morbid obesity (Figure 24-36). What operation was performed? 237
51. A 27-year-old woman underwent surgery for morbid obesity and now presents with left upper quadrant pain and regurgitation. Figure 24-37, A, is a spot radiograph from a study performed 14 months before the image shown in Figure 24-37, B. What has happened? 237
52. A 29-year-old woman had a sleeve gastrectomy 6 weeks ago and now complains of vomiting after small meals. Figure 24-38 is from an upper GI series. What is your diagnosis? 237
Bibliography 239
25 CT and MRI of the Upper Gastrointestinal Tract 240
1. What are the general indications for routine computed tomography (CT) and magnetic resonance imaging (MRI) of the upper gastrointestinal (GI) tract? 240
2. How are computed tomographic enterography (CTE) and magnetic resonance enterography (MRE) different from routine CT or MRI scans of the abdomen and pelvis? 240
3. What are the major clinical indications for CTE and MRE? 240
4. What is the normal CT and MRI appearance of the upper GI tract? 240
5. What is the hallmark of GI tract pathology on cross-sectional imaging? 240
6. What is the “target” sign? 241
7. What is the “fat halo” sign? 242
8. What is the “comb” sign? 242
9. What is the “small bowel feces” sign? 242
10. What does active GI bleeding look like on CTE or MRE images? 242
11. What are some cross-sectional imaging features that suggest presence of bowel malrotation? 242
12. What are some causes of esophagitis? 242
13. What are the typical imaging features of esophagitis on CT and MRI? 242
14. What is achalasia? 243
15. How can one distinguish between primary achalasia and secondary achalasia based on clinical and cross-sectional imaging features? 244
16. What are esophageal varices, and what is their appearance on CT and MRI? 244
17. What is the difference between uphill and downhill varices of the esophagus? 245
18. What types of esophageal diverticula are there? 245
19. Can diverticula occur in the remainder of the upper GI tract? 245
20. What is the most common benign tumor of the esophagus? 245
21. What is an esophageal fibrovascular polyp? 245
22. What are the two major types of esophageal cancers? 245
23. What are the cross-sectional imaging features of esophageal malignancy? 245
24. What is a hiatal hernia, and what types are there? 246
25. What are some causes of gastric wall thickening? 246
26. What are the typical imaging features of gastritis on CT and MRI? 246
27. What is the major differential diagnosis for gas seen in the wall of the stomach? 246
28. What are the major types of GI tract malignancies? 247
29. What is linitis plastica? 247
30. What are the cross-sectional imaging features of GI tract adenocarcinoma? 247
31. What are the cross-sectional imaging features of GI tract lymphoma? 248
32. What are the cross-sectional imaging features of gastrointestinal stromal tumor (GIST)? 249
33.\tWhat are the cross-sectional imaging features of GI tract carcinoid tumor? 249
34. What is carcinoid syndrome, and how often does it occur in patients with carcinoid tumor? 250
35. What types of malignancies most often metastasize hematogenously to the GI tract? 250
36. What are the main causes of small bowel wall thickening based on the spatial extent of bowel involvement? 250
37. What is Crohn’s disease? 251
38. What are the cross-sectional imaging features of Crohn’s disease in the GI tract? 251
39. What are the cross-sectional imaging features of Crohn’s disease outside of the GI tract? 251
40. What is an enteric duplication cyst? 251
41. What is the difference between an external hernia and an internal hernia? 251
42. What is the role of CT and MRI in the evaluation of patients with a hernia? 252
43. What is the most common type of external hernia? 252
44. What are the boundaries of Hesselbach’s triangle? 252
45. How can one distinguish direct inguinal hernias from indirect inguinal hernias on cross-sectional imaging? 252
46. What is a femoral hernia? 252
47. What is a Richter hernia? 252
48. What are the boundaries of the superior lumbar triangle? 252
49. What are the boundaries of the inferior lumbar triangle? 252
50. What is a lumbar hernia? 253
51. What are the major potential complications of a hernia? 253
Bibliography 253
26 Fluoroscopy of the Lower Gastrointestinal Tract 255
1. Identify the parts of the colon (numbers 1 through 8) labeled in Figure 26-1. 255
2. What are haustra? 255
3. Figure 26-4 is from what type of examination? 256
4. In what position is the patient lying on the tabletop of the fluoroscope in Figure 26-1? 256
5. What type of patient is capable of undergoing a double-contrast barium enema examination? 256
6. Figure 26-5 is an image from what type of examination? 257
7. What are the indications for a double-contrast barium enema examination? 257
8. What are the indications for a single-contrast barium enema examination? 257
9. What is your hospital’s preparation for a barium enema? 257
10. Which types of patients may require more than the standard barium enema preparation? 258
11. List the contraindications for a barium enema examination. 258
12. What are the contraindications for the use of intravenous glucagon? 258
13. Which types of patients should be scheduled early in the day? 258
14. What are the complications of a barium enema examination? 258
15. Is antibiotic prophylaxis needed before administration of a barium enema? 258
16. What is the most important radiographic predictor of malignancy arising in a polyp? 258
17. What does fine lobulation of the surface of a polyp mean? 259
18. What percentage of colonic cancers is out of reach of the flexible sigmoidoscope? 259
19. Which of the following morphologic shapes is the most common form of symptomatic colonic carcinoma: polypoid, carpet, plaquelike, or annular? 259
20. What is the most common cause of colonic intussusception in adults? 259
21. Hyperplastic polyps are found most commonly in what part of the colon? 259
22. What is the most common tumor arising in the submucosa of the colon? 260
23. What tumors commonly spread to the intraperitoneal space? 260
24. What are the differences in distribution between ulcerative colitis and Crohn’s disease? 260
25. Aphthoid ulcers are characteristic of which chronic inflammatory bowel disease? 261
26. What is the first radiographic study that is performed in symptomatic patients with previously diagnosed Crohn’s disease? 262
27. What is the most common form of colitis in an outpatient older than 50 years? 264
28. A woman with a history of cervical cancer now has rectal bleeding (Figure 26-15). What is the most likely diagnosis? 264
29. What are colonic diverticula? 264
30. Describe the distribution of colonic diverticula. 264
31. What is the primary muscle abnormality in diverticular disease? 265
32. An elderly patient presents with acute left lower abdominal pain. The clinical concern is acute diverticulitis. What examination is performed first? 265
33. Figure 26-18 is an image from a CT scan in a patient with acute left lower quadrant abdominal pain. What is your diagnosis? 265
34. A young woman complains of left lower quadrant pain (Figure 26-20). What is your diagnosis? 266
35. What is defecography? 267
36. What types of symptoms are indications for defecography? 267
37. What happens to a patient during defecography? 267
38. What abnormalities are detected during defecography that are not identified during endoscopy or barium enema? 268
39. What are the indications for a water-soluble contrast enema? 268
40. A water-soluble contrast enema is performed in a patient with a hand-sewn end-to-end colorectal anastomosis, after resection of a colonic adenocarcinoma. What is the diagnosis in Figure 26-23? 269
Bibliography 269
27 CT and MRI of the Lower Gastrointestinal Tract 270
1. What is shown in Figure 27-1? 270
2. What is the adenoma-carcinoma sequence? 270
3. What is the risk of malignancy in a colonic adenomatous polyp measuring <1 cm? 270
4. What is the risk of malignancy in a colonic adenomatous polyp measuring 1 cm? 270
5. What is the diagnostic performance of CTC compared to traditional or optical colonoscopy (OC) for adenomatous polyps? 270
6. What is the protocol for CTC? 271
7. Can CTC be performed without a cathartic bowel preparation? 271
8. What are the three factors that should be optimized on CTC? 271
9. What are the differences between a primary “2D” and a primary “3D” read on CTC? 271
10. What is the “polyp” window? 271
11. What is the differential diagnosis for a focal mass projecting into the colon lumen on 3D images (prior to correlation with the 2D images)? 271
12. What is the major differential diagnosis for a focal polypoid soft tissue attenuation colonic lesion on CTC? 272
13. How is a colonic diverticulum diagnosed on CTC? 272
14. How do diverticula of the gastrointestinal tract form? 272
15. What are the three methods utilized to distinguish stool from polyps on CTC? 272
16. What is the definition of a “clinically significant polyp” on CTC? 272
17. How frequently should CTC be performed? 273
18. What are the most commonly observed indications for CTC? 273
19. When is CTC not recommended? 274
20. What is the role of routine computed tomography (CT) and magnetic resonance imaging (MRI) in colon cancer screening? 274
21. What are the complications of CTC? 274
22. What is the radiation dose for CTC? 274
23. Why do patients prefer CTC to OC? 274
24. What is the normal cross-sectional imaging appearance of the colon? 274
25. What are the major nonneoplastic causes of colonic wall thickening? 274
26. What is the “target” sign, and what is its significance? 274
27. What are the CT and MR imaging features of infectious colitis? 275
28. What is the etiology of pseudomembranous colitis? 275
29. How is pseudomembranous colitis diagnosed? 275
30. What are the cross-sectional imaging features that are helpful to distinguish pseudomembranous colitis from other forms of colitis? 275
31. What is the treatment for pseudomembranous colitis? 275
32. What is the role of CT in the management of pseudomembranous colitis? 275
33. What is typhlitis? 275
34. How is typhlitis diagnosed? 275
35. What is the treatment of typhlitis? 276
36. What are the causes of ischemic colitis? 276
37. What is the most common cause of ischemic colitis? 276
38. What is the most common finding of ischemic colitis on CT? 276
39. What causes colonic wall thickening in ischemic colitis? 278
40. What generally causes more severe bowel wall thickening, arterial or venous occlusion? 278
41. Does the degree of bowel wall thickening correlate with the severity of ischemia? 278
42. What are other ancillary findings of ischemic bowel? 278
43. What is the preferred imaging modality for evaluation of bowel ischemia? 279
44. What are the “watershed” regions of the colon? 279
45. What is the role of CT and MRI in the detection of early inflammatory bowel disease? 279
46. How are Crohn’s disease and ulcerative colitis distinguished on cross-sectional imaging? 279
47. What percent of patients with Crohn’s disease present with isolated colonic involvement? 279
48. What is the most common finding of inflammatory bowel disease on CT and MRI? 279
49. What is the “comb” sign? 279
50. What are the MRI findings of active Crohn’s disease? 279
51. What is the significance of the degree of bowel wall enhancement in inflammatory bowel disease? 280
52. What is the significance of the “fat halo” sign? 281
53. What is the best technique for the evaluation of colovesical fistula? 281
54. Is colorectal cancer common? 282
55. What proportion of patients with colorectal cancer have synchronous colonic cancers? 282
56. What is the frequency of metastatic disease on initial presentation of colorectal cancer? 282
57. What are the most common locations of metastases in colorectal cancer? 282
58. What are the CT and MRI findings of colorectal cancer? 282
59. What is the most sensitive imaging study to detect colorectal cancer in the setting of a negative routine CT study and rising carcinoembryonic antigen (CEA) levels? 283
60. What is the frequency of primary colonic lymphoma? 283
61. What are the most common locations of colonic lymphoma? 283
62. What are the cross-sectional imaging features that help to distinguish colorectal lymphoma from adenocarcinoma? 283
63. What is the most common site of extrapulmonary tuberculosis? 283
64. What percentage of patients with gastrointestinal tuberculosis demonstrate no evidence of pulmonary tuberculosis? 283
65. What is the most common site of abdominal tuberculosis? 283
66. What are the findings of abdominal tuberculosis on CT and MRI? 283
67. What is familial adenomatous polyposis (FAP)? 284
68. What is the most common location of the polyps in patients with FAP? 284
69. What are the major variants of FAP? 284
70. What is the risk of colorectal cancer among patients with untreated FAP? 284
71. What is the treatment for FAP? 284
72. What is an appendiceal mucocele? 284
73. What do appendiceal mucoceles correspond to on pathology? 284
74. What are the cross-sectional imaging findings of an appendiceal mucocele? 284
75. What is pseudomyxoma peritonei? 284
76. What is the treatment for an appendiceal mucocele? 284
Bibliography 285
28 CT and MRI of the Liver, Gallbladder, and Biliary Tract 286
1. What are the common indications for computed tomography (CT) and magnetic resonance imaging (MRI) of the liver, gallbladder, and biliary tree? 286
2. What are the typical MRI sequences that are acquired for hepatobiliary imaging? 286
3. What is magnetic resonance cholangiopancreatography (MRCP)? 286
4. What are hepatobiliary MRI contrast agents? 286
5. What is the normal appearance of the liver on CT and MRI? 286
6. What is the normal segmental anatomy of the liver, and how are hepatic lobes and segments identified on cross-sectional imaging? 288
7. What is the normal appearance of the biliary tree and gallbladder on cross-sectional imaging? 288
8. What are the common MR imaging features to determine if a focal hepatic lesion is hepatocellular or extrahepatocellular in origin? 289
9. What is the role of CT and MRI in hepatic transplantation? 291
10. What is FNH, and what are its CT and MR imaging features? 291
11. What is hepatic adenoma, and what are its CT and MR imaging features? 291
12. How does one differentiate FNH from hepatic adenoma on cross-sectional imaging? 291
13. How does one differentiate FNH from fibrolamellar hepatocellular carcinoma (HCC) on cross-sectional imaging? 291
14. What are the two most commonly encountered benign hepatic lesions? 292
15. What are the CT and MR imaging features of a hepatic cyst? 292
16. What are the CT and MR imaging features of a hepatic hemangioma? 292
17. What is nonalcoholic fatty liver disease (NAFLD), and what is nonalcoholic steatohepatitis (NASH)? 294
18. What are the CT and MR imaging features of hepatic steatosis? 295
19. What does hepatic iron deposition look like on CT and MRI, and what are its major causes? 296
20. What are the hepatic and extrahepatic imaging features of cirrhosis? 297
21. What is HCC, and what are its CT and MR imaging features? 298
22. What are the Milan criteria? 298
23. What are the CT and MR imaging features of hepatic metastatic disease? 298
24. List the types of malignant tumors that most commonly lead to hyperenhancing hepatic lesions on arterial phase postcontrast CT or MR images. 300
25. What are the CT and MR imaging features of a hepatic pyogenic abscess? 300
26. What CT imaging findings may be encountered in hepatic trauma? 300
27. What is cholelithiasis, and what is choledocholithiasis? 301
28. What are the CT and MR imaging features of gallbladder and biliary tree calculi? 301
29. What is primary sclerosing cholangitis (PSC), and what are its CT and MR imaging features? 302
30. Describe the classification and cross-sectional imaging features of choledochal cysts. 302
31. What is the cross-sectional imaging appearance and clinical significance of a gallbladder polyp? 303
32. What is gallbladder carcinoma, and what are its CT and MR imaging features? 303
33. What is cholangiocarcinoma, and what are its CT and MR imaging features? 304
Bibliography 305
29 CT and MRI of the Spleen 306
1. What is the normal CT and MRI appearance of the spleen? 306
2. What is the normal enhancement pattern of the spleen? 306
3. What is the difference between white pulp and red pulp? 306
4. What is an accessory spleen? 306
5. What is an upside-down spleen? 306
6. What is splenosis? 306
7. What is the major differential diagnosis of splenomegaly? 306
8. What is the most common cause of a small spleen? 306
9. What are some causes of splenic calcification? 306
10. What does splenic iron deposition look like on MRI, and what are some major causes of iron deposition in the spleen? 306
11. What are the CT and MRI findings of splenic infarction? 307
12. What abdominal organ is most commonly injured due to blunt abdominal trauma? 308
13. What are some benign cystic lesions that may involve the spleen? 309
14. What are some benign solid lesions that may involve the spleen? 309
15. What are some malignant lesions that may involve the spleen? 310
16. How are incidentally detected splenic lesions generally managed? 311
17. What is polysplenia? 311
18. What is asplenia? 311
Bibliography 311
30 CT and MRI of the Pancreas 313
1. What are the general indications for computed tomography (CT) and magnetic resonance imaging (MRI) of the pancreas? 313
2. What is magnetic resonance cholangiopancreatography (MRCP), and how does it compare with endoscopic retrograde cholangiopancreatography (ERCP)? 313
3. What is the normal CT and MRI appearance of the pancreas? 314
4. What blood vessels are found near the pancreas? 315
5. What structures may be seen in the portacaval space? 315
6. What is pancreas divisum? 315
7. What is an annular pancreas? 315
8. What is an intrapancreatic splenule? 315
9. What are some causes of pancreatic fatty replacement? 316
10. What does pancreatic iron deposition look like on MRI, and what is the major cause? 316
11. What is the role of CT and MRI in the assessment of patients with acute pancreatitis? 317
12. What are the most common causes of acute pancreatitis? 317
13. What are the two major types of acute pancreatitis, and how do they appear on cross-sectional imaging? 317
14. Describe the four types of pancreatic and peripancreatic collections that may occur in the setting of acute pancreatitis. 318
15. What are some other local complications of acute pancreatitis? 319
16. What are the CT and MR imaging features of chronic pancreatitis? 319
17. What is groove pancreatitis? 319
18. Are there any CT or MR imaging features that may indicate the presence of autoimmune pancreatitis? 319
19. What cross-sectional imaging findings may be encountered in pancreatic trauma? 319
20. What cross-sectional imaging findings suggest presence of a pancreatic ductal injury? 321
21. What is the major differential diagnosis for focal pancreatic lesions? 321
22. What lesion can mimic a pancreatic cystic lesion on cross-sectional imaging? 321
23. How are incidentally detected pancreatic cystic lesions generally managed? 321
24. What conditions are associated with pancreatic epithelial cyst formation? 321
25. What pancreatic lesions are associated with vHL syndrome? 321
26. What is a pancreatic serous cystadenoma? 321
27. What are the different types of pancreatic mucinous cystic neoplasms? 321
28. What is pancreatic adenocarcinoma, and what are its CT and MR imaging features? 322
29. What CT and MR imaging findings indicate unresectability of pancreatic adenocarcinoma? 323
30. What is the “double duct” sign? 324
31. What are pancreatic neuroendocrine tumors? 324
32. What are the two most common types of pancreatic neuroendocrine tumor? 324
33. What characteristic clinical presentations are associated with specific types of functional pancreatic neuroendocrine tumors? 324
34. What genetic syndromes may be associated with pancreatic neuroendocrine tumors? 324
35. What is a pancreatic solid pseudopapillary neoplasm (SPN)? 324
36. What are the most common primary tumors that metastasize hematogenously to the pancreas? 325
Bibliography 325
31 CT and MRI of the Peritoneum, Omentum, and Mesentery 327
1. What is the peritoneum? 327
2. What are peritoneal ligaments, small bowel mesentery, mesocolon, and omentum? 327
3. What is the anatomy of the abdominal peritoneal cavity? 327
4. What is the anatomy of the pelvic peritoneal cavity? 327
5. What is the differential diagnosis for nonparenchymal cystic lesions in the abdomen and pelvis? 328
6. List some potential complications that may occur with nonparenchymal cystic lesions. 328
7. Are there any distinctive CT and MR imaging features of specific types of nonparenchymal cystic lesions? 328
8. What are the major causes of transudative ascites? 328
9. What are the major causes of exudative ascites? 328
10. Are there CT and MR imaging features that can distinguish between transudative and exudative ascites? 328
11. What specific types of fluid collection may occur? 329
12. What are the major causes of pneumoperitoneum? 329
13. What is pseudomyxoma peritonei, and what are its CT and MR imaging features? 329
14. What is peritoneal carcinomatosis, and what are its CT and MR imaging features? 329
15. What is malignant peritoneal mesothelioma, and what are its CT and MR imaging features? 329
16. What is primary peritoneal carcinoma (PPC), and how can one distinguish this from peritoneal spread of ovarian cancer on CT and MR imaging? 330
17. What is intraabdominal desmoplastic small round cell tumor (DSRCT), and what are its CT and MR imaging features? 330
18. What is sclerosing mesenteritis? 330
19. What are the CT and MR imaging features of sclerosing mesenteritis? 330
20. What is pelvic lipomatosis? 330
21. What are the CT and MR imaging features of pelvic lipomatosis? 330
22. What is a desmoid tumor? 332
23. What are the CT and MR imaging features of desmoid tumors? 332
24. What are the major types of peritonitis? 332
25. What are some differences between primary and secondary bacterial peritonitis? 333
26. What are the CT and MR imaging features of peritonitis? 333
27. What is sclerosing encapsulating peritonitis, and what are its CT and MR imaging features? 333
Bibliography 334
32 CT and MRI of the Acute Abdomen and Pelvis 335
1. Why is computed tomography (CT) commonly used initially for diagnostic purposes in patients with an acute abdomen or pelvis? 335
2. When is magnetic resonance imaging (MRI) used for diagnostic purposes in patients with an acute abdomen or pelvis? 335
3. When are oral and intravenous contrast materials for CT and MRI administered to patients with an acute abdomen or pelvis? 335
4. What is the major differential diagnosis for acute abdominopelvic conditions that can be diagnosed on CT and MRI? 335
5. What is an abscess, and what are its CT and MR imaging features? 336
6. What is acute appendicitis? 336
7. Describe the CT and MR imaging features of acute appendicitis. 336
8. What is tip appendicitis? 337
9. What is acute large bowel diverticulitis, and what are its CT and MR imaging features? 337
10. Describe acute mesenteric lymphadenitis and its associated CT and MR imaging features. 337
11. Describe primary epiploic appendagitis (PEA) and segmental omental infarction and their associated CT and MR imaging features. 337
12. What is acute cholecystitis? 338
13. List the CT and MR imaging findings of acute cholecystitis. 338
14. What is gangrenous cholecystitis, and what are its CT and MR imaging features? 339
15. Describe emphysematous cholecystitis and its CT and MR imaging features. 339
16. What is the major complication of acute, gangrenous, and emphysematous cholecystitis? 339
17. What is ascending cholangitis, and what are its CT and MR imaging features? 339
18. What is acute pancreatitis? 339
19. Describe the CT and MR imaging features of acute pancreatitis. 339
20. What is acute pyelonephritis, and what are its CT and MR imaging features? 340
21. What is emphysematous pyelonephritis, and what are its CT and MR imaging features? 340
22. Describe the CT and MR imaging features of urolithiasis along with its associated complications. 340
23. What is pyonephrosis, and what are its CT and MR imaging features? 341
24. What is pelvic inflammatory disease (PID), and what are its CT and MR imaging features? 341
25. List the major causes of bowel obstruction. 341
26. Describe the CT and MR imaging features of bowel obstruction. 342
27. What is a closed loop bowel obstruction, and what are its CT and MR imaging features? 342
28. Describe the CT and MR imaging features of bowel ischemia/infarction. 343
29. List some causes of bowel ischemia/infarction. 343
30. What is toxic megacolon, and what are its CT and MR imaging features? 343
31. List the major causes of bowel perforation. 344
32. What are the CT and MR imaging features of bowel perforation? 344
33. Describe the CT imaging features of acute hemorrhage and active arterial hemorrhage. 344
34. Describe the CT imaging features of AAA rupture and impending rupture. 345
35. What are the CT and MR imaging features associated with shock, and what should one do upon seeing these findings? 345
36. List the major CT imaging features associated with solid organ traumatic injury. 345
37. Describe the major CT imaging features related to hollow organ traumatic injury. 345
38. What are the major CT and MR imaging features associated with vascular traumatic injury? 345
39. What is Fournier gangrene, and what are its CT and MR imaging features? 345
40. What is abdominal compartment syndrome (ACS), and what are its CT and MR imaging features? 346
41. What is ectopic pregnancy, and what are its CT and MR imaging features? 346
42. What is adnexal torsion, and what are its CT and MR imaging features? 346
Bibliography 347
VI Genitourinary Imaging 349
33 Urography 351
1. What is a urogram? 351
2. What are the different ways a urogram can be performed? 351
3. What is IVU? 351
4. What is CTU? 351
5. What is MRU? 351
6. What are the pros and cons of the three different imaging techniques available for urography? 351
7. What preprocedure preparation is required for the different urographic techniques? 351
8. When is CTU or IVU contraindicated? 352
9. When is MRU contraindicated? 354
10. What is the sequence of images for an IVU? 354
11. How should a patient with hematuria be evaluated? 354
12. What should be done if IVU suggests the presence of a renal mass? 354
13. My patient presented with diffuse lung metastases and gross hematuria. What study would be best to look for a renal malignancy? 354
14. Why is urography necessary in patients with urothelial cancer of the urinary bladder? 354
15. What does upper tract UC look like on urography? 355
16. What is bladder cancer? 355
17. What are the IVU, CT, and MR imaging features of bladder cancer? 356
18. What is the appearance of urinary tract stones on imaging studies? 356
19. Is a filling defect in the collecting system diagnostic of UC? 357
20. How do I distinguish between these different pathologic conditions? 357
21. What is the appearance of urinary tract obstruction on an IVU, CTU, and MRU? 358
22. What is the role of urography in a patient with suspected urinary tract obstruction? 358
23. What is a stone-protocol CT? 358
24. My patient has severe flank pain. What study should I order to exclude renal colic as a cause of the flank pain? 358
25. As a stone-protocol CT detects all renal stones, when is urography necessary in patients with urinary tract stones? 358
26. What are calyceal diverticula? 358
27. What is medullary sponge kidney? 358
28. What is ureteropelvic junction (UPJ) obstruction? 359
29. What is an ectopic ureter? 360
30. What is meant by duplication of the collecting system, and what is its appearance on radiographic studies? 360
31. What is a ureterocele? 361
32. What is papillary necrosis? 361
33. What is the imaging appearance of infections in the urinary tract? 361
34. My patient is status post surgery for an abdominal tumor several days ago, and the surgical drains are putting out a lot of yellow fluid. What should I do? 362
Bibliography 362
34 Genitourinary Tract Fluoroscopy 363
1. What are genitourinary fluoroscopic examinations? 363
2. What is a retrograde pyelogram, and how does it differ from a urogram? 363
3. When is a retrograde pyelogram necessary? 363
4. What is the difference between a cystogram and a voiding cystourethrogram? 363
5. What are the indications for cystography and VCUG? 363
6. What is a retrograde urethrogram? 363
7. What are the indications for a retrograde urethrogram? 364
8. How is the female urethra evaluated? 364
9. What is a loopogram? 364
10. What is a pouchogram? 365
11. What is a hysterosalpingogram? 366
12. What is the normal appearance of the upper urinary tract on a retrograde pyelogram? 367
13. What are some abnormalities that may be seen on a retrograde pyelogram? 367
14. What are the causes of ureteral trauma, and how is it best evaluated? 368
15. Why is vesicoureteral reflux (VUR) important, and how is it demonstrated? 369
16. What is the normal appearance of the bladder on fluoroscopic studies? 369
17. What is a cystocele? 369
18. What are some causes of incontinence? 369
19. Is a cystogram sensitive in excluding a leak from the bladder? 369
20. A patient is brought to the emergency department with blunt abdominal trauma and pelvic fractures. Does this patient need both an abdominopelvic CT scan and a fluoroscopic cystogram? 369
21. What kinds of injuries occur in the bladder? 369
22. What are the imaging findings of cystitis? 370
23. What are the causes of bladder fistulae? 370
24. What is a bladder diverticulum? 370
25. What are some causes of urethral stricture? 370
26. What is a urethral diverticulum? 370
27. What kinds of traumatic injuries occur in the urethra? 370
28. What is the normal appearance of the female genital tract on a hysterosalpingogram? 370
29. Does pelvic magnetic resonance imaging (MRI) or ultrasonography (US) provide the same information as HSG? 371
30. What are some abnormalities seen on a hysterosalpingogram? 371
31. If a female patient has a pelvic mass, what study would be helpful for further evaluation? 371
32. Is a hysterosalpingogram useful for evaluation of the endometrium in a postmenopausal patient with vaginal bleeding? 371
Bibliography 372
35 CT and MRI of the Kidney 373
1. What are the common indications for computed tomography (CT) and magnetic resonance imaging (MRI) of the kidneys? 373
2. What is the normal appearance of the kidneys on CT and MRI? 373
3. What is the role of CT and MRI in renal transplantation? 373
4. What is a horseshoe kidney? 375
5. What is the most common benign renal lesion? 375
6. What is a cystic nephroma, and what are its CT and MR imaging features? 375
7. What is the Bosniak classification system for cystic renal lesions? 376
8. What is the major differential diagnosis for polycystic kidney disease? 376
9. What is the major differential diagnosis for focal renal lesions? 379
10. What is a renal AML, and what are its CT and MR imaging features? 379
11. What is a renal oncocytoma, and what are its CT and MR imaging features? 379
12. What is acute pyelonephritis, and what are its CT and MR imaging features? 379
13. What are the CT and MR imaging features of a renal pyogenic abscess? 380
14. What is xanthogranulomatous pyelonephritis (XGP), and what are its CT and MR imaging features? 381
15. What is the difference between nephrolithiasis and nephrocalcinosis? 381
16. What are the major causes of cortical nephrocalcinosis? 381
17. What are the major causes of medullary nephrocalcinosis? 382
18. What does renal iron deposition look like on MRI, and what are its major causes? 382
19. What CT imaging findings may be encountered in renal trauma? 382
20. What do renal infarcts look like on CT and MRI, and what are some causes of renal infarction? 383
21. What are some risk factors for renal hemorrhage/hematoma? 383
22. What is RCC, and what are its histologic subtypes? 384
23. What are the CT and MR imaging features of RCC? 384
24. What are some hereditary conditions and other risk factors associated with RCC? 384
25. Summarize the American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) staging system for renal cell carcinoma. 385
26. What are the major indications for partial nephrectomy in patients with RCC? 387
27. What are the CT and MR imaging features of renal lymphoma? 387
28. What are the CT and MR imaging features of metastatic disease to the kidneys? 387
29. What are the CT and MR imaging features of urothelial cancers of the upper urinary tract? 387
Bibliography 388
36 CT and MRI of the Adrenal Glands 389
1. What are common indications for computed tomography (CT) and magnetic resonance imaging (MRI) of the adrenal glands? 389
2. What is the normal appearance of the adrenal glands on CT and MRI? 389
3. What is a pancake adrenal gland? 389
4. What is the significance of hyperenhancement of the adrenal glands? 389
5. What are the major causes of adrenal gland calcification? 389
6. How often are incidental adrenal lesions detected on cross-sectional imaging? 389
7. What is the major differential diagnosis for a focal adrenal gland lesion? 391
8. What are the CT and MR imaging findings of adrenal hemorrhage/hematoma? 391
9. What are some risk factors for adrenal hemorrhage/hematoma? 391
10. What are the CT and MR imaging findings of adrenal cysts? 392
11. What is adrenal hyperplasia, and what are its CT and MR imaging features? 392
12. What is an adrenal adenoma, and what are its CT and MR imaging features? 393
13. Are CT and MRI able to distinguish between hyperfunctional and nonhyperfunctional adrenal adenomas? 393
14. What is an adrenal myelolipoma, and what are its CT and MR imaging features? 393
15. What other types of adrenal gland nodules may contain microscopic lipid or macroscopic fat? 393
16. If the CT or MR imaging features of an incidentally detected adrenal gland nodule are nondiagnostic, what are the next steps to determine its etiology? 394
17. What are the causes of Conn’s syndrome? 394
18. What are the causes of Cushing’s syndrome? 395
19. What is an adrenal pheochromocytoma, and what are its CT and MR imaging features? 396
20. What are some hereditary conditions associated with adrenal pheochromocytoma? 396
21. What is adrenal cortical carcinoma (ACC), and what are its CT and MR imaging features? 396
22. What are the cross-sectional imaging features of metastatic disease to the adrenal glands? 396
Bibliography 398
37 CT and MRI of the Retroperitoneum 399
1. What are the boundaries of the retroperitoneum? 399
2. What are the compartments of the retroperitoneum and their contents? 399
3. What are the extraperitoneal spaces of the pelvis? 399
4. Are the psoas muscles located within the retroperitoneum? 399
5. Which tumors most commonly occur in the retroperitoneum? 399
6. What are the major types of retroperitoneal sarcoma? 399
7. How are computed tomography (CT) and magnetic resonance imaging (MRI) useful in patients with retroperitoneal sarcoma? 399
8. What are the CT and MR imaging features of a retroperitoneal sarcoma? 399
9. What CT and MR imaging features favor a liposarcoma over a lipoma? 401
10. What clinical and imaging features favor presence of a retroperitoneal leiomyosarcoma? 401
11. What are some clinical, CT, and MR imaging features of schwannoma? 401
12. What are some clinical, CT, and MR imaging features of neurofibroma? 401
13. How often do patients with NF-1 develop neurofibromas? 402
14. When should one suspect malignant transformation of a neurofibroma into an MPNST? 402
15. What are some clinical, CT, and MR imaging features of paraganglioma? 402
16. What are the CT and MR imaging features of retroperitoneal lymphoma? 402
17. What CT and MR imaging findings can help distinguish benign from malignant lymph nodes? 402
18. What is the differential diagnosis for abdominopelvic lymphadenopathy? 403
19. What are the major causes of necrotic lymph nodes? 403
20. What are the major causes of calcified lymph nodes? 403
21. What are the major causes of fatty lymph nodes? 403
22. What are some imaging manifestations of retroperitoneal metastasis? 403
23. Which malignant tumors most often spread to the retroperitoneum? 403
24. What is RPF? 403
25. What are the CT and MR imaging features of RPF? 403
26. What are the major risk factors for retroperitoneal hemorrhage? 404
27. What are the CT and MR imaging features of hemorrhage? 404
28. What is a urinoma, and what are its major risk factors? 404
29. What are the CT and MR imaging features of a urinoma? 404
30. What are the major causes of pneumoretroperitoneum? 404
Bibliography 405
38 Imaging of the Female Pelvis 406
1. What is the first-line imaging modality of the female pelvis and why? 406
2. How are US, CT, and MRI of the female pelvis performed? 406
3. Which imaging modality best demonstrates the anatomy of the uterus? 406
4. What are the more common congenital uterine anomalies and their clinical significance? 407
5. What is the normal thickness of the endometrium in a premenopausal patient? 407
6. What is the normal thickness of the endometrium in postmenopausal patients, and what is the significance of thickened endometrium in these patients? 407
7. What are the most common causes of vaginal bleeding in a postmenopausal woman? 407
8. In a postmenopausal patient with vaginal bleeding, what is the role of imaging? 408
9. What is adenomyosis, and what are its imaging characteristics? 409
10. What is the most common neoplasm of the female genitourinary tract? 410
11. What is Asherman’s syndrome, and what are its imaging characteristics? 410
12. What is the normal size of the ovaries in premenopausal versus postmenopausal women? 410
13. What are the most common benign lesions of the ovaries and their imaging characteristics? 410
14. What is the recommended management of an incidentally discovered asymptomatic simple ovarian cyst seen on US in premenopausal versus postmenopausal women? 410
15. What are the imaging findings of endometriosis on US and MRI? 411
16. What are the major causes of hydrosalpinx and hematosalpinx, and what are their imaging features on US and MRI? 411
17. What are the imaging features of a mature teratoma of the ovary? 412
18. In a female patient with acute pelvic pain and suspected adnexal torsion, what is the study of choice, and what are the imaging findings of adnexal torsion? 413
19. How is polycystic ovarian syndrome (PCOS) diagnosed, and what is the role for imaging? 413
20. What are the most common malignancies of the female reproductive system? 414
21. How is endometrial cancer diagnosed, and what imaging features are considered in staging? 415
22. How is cervical cancer diagnosed, and what tumor features are considered in staging and pretreatment planning? 415
23. What are the major imaging features that suggest presence of an ovarian neoplasm? 415
24. What are the most common perineal cystic lesions seen in the female patient? 416
25. In a patient with cervical motion tenderness and suspected pelvic inflammatory disease (PID), what is the role of imaging? 416
26. In a multiparous patient with stress urinary incontinence, vaginal bulging, incomplete defecation, and suspected pelvic organ prolapse, what is the role of imaging? 416
27. In a female patient with postvoid dribbling, dysuria, dyspareunia, and recurrent urinary tract infections, what is the differential diagnosis? 417
28. What are the imaging features of intrauterine devices (IUDs)? 418
29. What is the recommended imaging study in a pregnant patient with right lower quadrant pain? 419
Bibliography 420
39 Imaging of the Male Pelvis 421
Prostate Gland and Seminal Tract 421
1. What is the normal anatomy and imaging appearance of the prostate gland and seminal tract on ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI)? 421
2. What are the clinical indications for cross-sectional imaging of the prostate gland and seminal tract? 421
3. What is the normal size of the prostate gland? 421
4. What is hematospermia, and what are its major causes? 423
5. What does hemorrhage in the prostate gland and seminal tract typically look like on MRI? 423
6. What is the significance of calcification of the vas deferens? 423
7. What kinds of cysts occur in the prostate gland and seminal tract? 423
8. What is prostatitis, and what are its cross-sectional imaging features? 424
9. Which patients are at risk for developing a prostatic abscess, and what are its cross-sectional imaging features? 424
10. What is benign prostatic hyperplasia (BPH), and what are its cross-sectional imaging features? 424
11. What is the major differential diagnosis for a focal prostatic lesion? 424
12. What is prostate cancer? 425
13. What is the Gleason score? 425
14. What is the role of cross-sectional imaging in the evaluation of patients with prostate adenocarcinoma? 425
15. What are the cross-sectional imaging features of prostate adenocarcinoma? 425
16. What are the cross-sectional imaging features that suggest extracapsular spread of prostate adenocarcinoma? 426
17. Summarize the American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) staging system for prostate adenocarcinoma. 426
Testicles, Epididymides, and Scrotum 426
18. What is the normal anatomy and imaging appearance of the testicles on US, CT, and MRI? 426
19. What is cryptorchidism, and what are its cross-sectional imaging features? 428
20. What are the potential complications of cryptorchidism? 428
21. What is the most important question to clarify when imaging a palpable scrotal abnormality? 428
22. What is the most common cause of a scrotal mass? 428
23. What is the major differential diagnosis for a focal testicular lesion? 429
24. What is the major differential diagnosis for multiple intratesticular masses? 429
25. What is a testicular adrenal rest, and what are its cross-sectional imaging features? 430
26. What is splenogonadal fusion, and what are its US imaging features? 430
27. What is Leydig cell hyperplasia, and what are its cross-sectional imaging features? 430
28. What is a testicular epidermoid inclusion cyst, and what are its cross-sectional imaging features? 430
29. What is testicular microlithiasis, and what is its significance? 430
30. What is the most common cancer of young men? 431
31. What types of testicular malignancy may occur? 431
32. Which type of testicular tumor is hormonally active? 431
33. What are some risk factors for testicular cancer? 431
34. What is the role of cross-sectional imaging in patients with testicular cancer? 431
35. What are the cross-sectional imaging features of testicular cancer? 431
36. Describe the routes of lymphatic spread of testicular cancer. 432
37. Which germ cell tumor has a tendency for early hematogenous metastatic spread? 433
38. List the stages of testicular cancer. 433
39. Are there findings that are more suggestive of testicular lymphoma rather than testicular germ cell tumor? 433
40. How often do extratesticular malignancies metastasize to the testicle? 433
41. What is the most common extratesticular scrotal tumor? 433
42. What is an adenomatoid tumor, and what are its cross-sectional imaging features? 433
43. What is a varicocele, and what are its cross-sectional imaging features? 433
44. What are the complications of a varicocele? 433
45. What is the significance of asymmetric prominence and enhancement of the spermatic cord vessels? 433
46. In a patient who presents with an acutely painful scrotum, what is the initial diagnostic imaging test of choice, and what is the major differential diagnosis? 434
47. What is acute epididymo-orchitis, and what are its cross-sectional imaging features? 434
48. What is the most common cause of isolated orchitis? 434
49. What is a pyocele, and what are its cross-sectional imaging features? 434
50. What is a hydrocele, and what are its cross-sectional imaging features? 435
51. List some causes of a hydrocele. 435
52. What is torsion of a testicular appendage, and what are its US imaging features? 435
53. What is spermatic cord torsion, and what are its US imaging features? 435
54. What cross-sectional imaging findings may be encountered in testicular trauma? 435
55. What are the US and MR imaging findings of testicular hematomas? 436
56. What are the US and MR imaging findings of segmental testicular infarction? 436
Penis 436
57. What is the normal anatomy and imaging appearance of the penis on US, CT, and MRI? 436
58. What congenital abnormality of the penis is associated with bladder exstrophy? 437
59. When the penile meatus is located more ventrally and proximally than expected, what is this congenital abnormality called, and what is an associated finding? 437
60. What is Peyronie’s disease, and what are its cross-sectional imaging features? 438
61. What is a Cowper duct syringocele, and what are its cross-sectional imaging features? 438
62. What cross-sectional imaging findings may be encountered in penile trauma? 438
63. If a patient presents with erectile dysfunction, what can one assess on Doppler US to evaluate for potential causes? 438
64. What is the most common malignancy of the penis, and what are some of its risk factors? 438
65. What is the role of cross-sectional imaging in patients with penile cancer? 438
66. What are the cross-sectional imaging features of penile cancer? 438
67. If a patient with known cancer presents with priapism, what diagnosis must be considered? 439
Bibliography 439
VII Neuroradiology 441
40 Brain Imaging 443
1. Identify the normal parts of the brain labeled 1 through 6 in Figure 40-1. 443
2. What imaging modalities can be used to evaluate the brain? 443
3. What are the clinical indications for obtaining CT and MRI of the brain? 443
4. What are contraindications for performing MRI of the brain? 444
5. Define the terms “intra-axial” and “extra-axial”, which are commonly used to localize intracranial pathologic conditions. 444
6. What is the Glasgow Coma Scale (GCS), and how is it used? 444
7. What is the imaging modality of choice in the setting of acute head trauma? 444
8. What is the role of imaging after concussion or other minor head trauma? 445
9. What are the advantages and drawbacks of MRI in assessing a trauma patient? 445
10. How does one differentiate a subdural hematoma from an epidural hematoma? 445
11. What is the CT appearance of subarachnoid hemorrhage (SAH)? 446
12. What are the five patterns of brain herniation and herniation syndromes? 446
13. What are Duret hemorrhages? 446
14. What are the imaging manifestations of a brain contusion? 447
15. What are the imaging manifestations of diffuse axonal injury (DAI)? 447
16. What is the most common primary intra-axial brain tumor in adults? What cell line does it arise from? 447
17. What is the most common extra-axial tumor in adults? 447
18. What are the most common neoplasms arising in the corpus callosum? 447
19. What are the most common neoplasms that metastasize to the brain? 447
20. What are the most common primary brain tumors that calcify? 447
21. What is the imaging appearance of leptomeningeal carcinomatosis or subarachnoid seeding? 447
22. What are the most common tumors that produce subarachnoid seeding in adults? 448
23. Why would a mass appear hyperattenuating on an unenhanced CT scan of the head? 448
24. What is the most common tumor in the cerebellopontine angle cistern? 448
25. What is the most common clinical presentation of a vestibular schwannoma? 449
26. What is the most common posterior fossa/infratentorial mass in adults? 449
27. What is pituitary apoplexy? 450
28. What is a pituitary microadenoma? What is a pituitary macroadenoma? 450
29. What visual symptoms can pituitary adenomas cause? What is the most common type of pituitary adenoma? 450
30. Name advanced imaging techniques that help differentiate brain tumors from other pathologies. 450
31. Pineal region masses are associated with what visual disturbance? 450
Bibliography 451
41 Brain Imaging 453
1. How is multiple sclerosis (MS) diagnosed? 453
2. What is the differential diagnosis of MS based on imaging findings? 453
3. What are the clinical and imaging features of acute disseminated encephalomyelitis (ADEM)? 453
4. What are the causes of intracranial abscesses? 454
5. What is the imaging differential diagnosis of a ring-enhancing lesion in the brain? 454
6. What advanced MRI techniques may be useful in distinguishing brain abscess from neoplasm? 454
7. What anatomic location in the brain is preferentially involved by herpes simplex encephalitis? 454
8. What is the differential diagnosis of an intracranial mass in a patient with human immunodeficiency virus (HIV) infection? 454
9. What is a stroke? 456
10. What are the common causes of stroke that one must consider in children and young adults? 456
11. What are the imaging manifestations of ischemic stroke in the acute stage? 456
12. How can one differentiate acute from chronic stroke on imaging? 457
13. What are watershed infarctions? 457
14. What are lacunar infarctions? 457
15. What are the risk factors for venous sinus thrombosis and venous infarction? 457
16. What is the most common cause of nontraumatic subarachnoid hemorrhage (SAH)? 457
17. What is the workup of a patient presenting with SAH? 458
18. If multiple aneurysms are seen on catheter angiography in a patient with SAH, which one most likely bled? 459
19. What are common locations for hypertensive intraparenchymal hemorrhages? 459
20. What is amyloid angiopathy? 459
21. Review the MRI signal intensity characteristics of intracranial hemorrhage. 459
22. What are the imaging features of cerebral hypoxia/anoxia? 459
Bibliography 461
42 Advanced Neurospinal Imaging 462
1. Identify parts of the spine labeled in Figure 42-1. 462
2. What imaging modalities are most often used in the evaluation of spine pathology? 462
3. Describe the strengths, weaknesses, and most appropriate uses of CT in spinal imaging. 462
4. Describe the strengths and drawbacks of MRI. 462
5. In patients with contraindications to MRI, what imaging study can be used to assess the contents within the spinal canal? 463
6. What is discography, and what are its indications? 463
7. What is the primary role of catheter angiography of the spine? 463
8. What is spinal dysraphia? 464
9. Differentiate between open and occult forms of spinal dysraphia. 464
10. What are the clinical findings and imaging features of a tethered spinal cord? 464
11. List and describe caudal spinal anomalies. 464
12. What are the split notochord syndromes? 465
13. What are Tarlov cysts? 465
14. What is arachnoiditis? 465
15. What are the CT and MR imaging and clinical features of hydrosyringomyelia? 466
16. Review the epidemiologic factors of spinal trauma. 467
17. What are the appropriate indications for obtaining imaging of the spine in the setting of blunt trauma? 467
18. What are the roles of CT and MRI in spinal trauma? 467
19. Describe types of spinal cord injuries. 468
20. What additional structures may be injured in association with cervical spinal trauma that may not be detected on radiographs or CT scans? 468
21. Name the most common sites of infection in the spine. 468
22. What patient populations are particularly prone to the development of infectious spondylodiscitis? 470
23. What is the most common infectious agent responsible for spondylodiscitis? 470
24. What is the typical clinical presentation of discitis? 470
25. What are the typical imaging findings of spondylodiscitis? 470
26. Describe the imaging appearance of spondylodiscitis caused by atypical organisms such as tuberculosis. 470
27. List noninfectious disorders that can have imaging findings similar to infectious spondylodiscitis. 470
28. What is the most common inflammatory disorder that affects the spinal cord? 471
29. What are the classic imaging findings of multiple sclerosis affecting the spinal cord? 471
30. What is the typical MRI appearance of spinal sarcoidosis? How can its appearance, combined with the clinical history, distinguish it from other inflammatory disorders? 471
31. What is the typical time course for the development of radiation myelitis after irradiation for treatment of tumor? 472
32. Which disorders commonly affect the dorsal spinal cord? 472
33. Name the two most common vascular disorders of the spinal cord. 472
34. What is the arterial vascular supply to the spinal cord? 472
35. What are the typical clinical characteristics and imaging findings of spinal cord infarcts? 472
36. List types of spinal vascular malformations, and describe their clinical and imaging characteristics. 473
37. How are spinal lesions classified anatomically? 475
38. Describe the clinical and imaging features of neural compression. 475
39. What is the most common epidural spinal tumor in adults? 475
40. What is the most common benign osseous lesion involving the spine? 476
41. What is the differential diagnosis for an intradural-extramedullary neoplasm? 476
42. What neoplasms are associated with leptomeningeal seeding of tumor? 476
43. List the most common intramedullary spinal tumors. 477
44. Describe the distinguishing clinical and imaging features of intramedullary spinal tumors. 477
Bibliography 479
43 Head and Neck Imaging, Part 1 480
1. The hyoid bone divides the neck into what two distinct regions? 480
2. Which imaging modalities are used to evaluate lesions in the suprahyoid and infrahyoid neck? 480
3. What are the three anatomic subdivisions of the pharynx? 480
4. Name the parts of the nasopharynx. 481
5. Name the parts of the oropharynx. 481
6. What is Waldeyer’s ring? 481
7. The piriform sinuses are in what part of the aerodigestive tract? 481
8. What structures are parts of the oral cavity? 481
9. What are the three anatomic subsites of the larynx? 481
10. What are the boundaries of the supraglottic larynx? 481
11. What structures comprise the glottis? 482
12. Where is the subglottis located? 482
13. Name and identify the extramucosal spaces of the head and neck in Figure 43-5. 482
14. Describe how displacement of the fat in the PPS helps to localize lesions or masses to their correct anatomic subsite in the extramucosal compartment. 483
15. Displacement of the prevertebral muscle complex helps differentiate masses in what two extramucosal spaces? 483
16. Displacement of the cervical internal carotid artery helps differentiate masses in what two extramucosal spaces? 483
17. What are the imaging criteria for diagnosis of a pathologic cervical lymph node? 483
18. What is the best cross-sectional imaging study to identify pathologic nodes? 483
19. What is the most common cause of a calcified cervical lymph node? 483
20. What is the most common cause of a cystic mass in the lateral neck of an adult? 485
21. What are the most common causes of cervical lymph node metastases in an adult? 485
22. In patients with head and neck cancer, how does the presence of metastatic lymphadenopathy affect prognosis? 485
23. What risk factors are associated with the development of head and neck cancer? 485
24. What major epidemiologic factor accounts for the increasing rate of head and neck cancer in adults younger than 40 years old? 485
25. What is the role of the radiologist in the evaluation and staging of head and neck cancer? 485
26. What treatment modalities are used for head and neck cancer? 485
27. What are the most common neck masses in a child? 485
Bibliography 486
44 Head and Neck Imaging, Part 2 487
1. What is the drainage pathway for the maxillary, frontal, and anterior ethmoid air cells? 487
2. In which paranasal sinus does malignancy most commonly arise? 487
3. On an unenhanced CT scan, what are common causes of hyperattenuating material within the paranasal sinuses? 488
4. What classic imaging finding supports the diagnosis of acute sinusitis in the appropriate clinical setting (facial pain, nasal drainage, fever)? 488
5. What are the three major salivary glands and the ducts that drain them? 488
6. Which salivary gland has the highest incidence of calculi/stones, and why? 488
7. Which salivary gland contains lymphoid tissue? What is the significance of this tissue? 488
8. What is the most common benign tumor of the salivary glands? 489
9. What are the most common malignancies of the salivary glands? 489
10. How is the size of the salivary gland related to the likelihood of a mass in the gland being malignant? 489
11. What imaging features distinguish a benign thyroid mass from a malignant thyroid mass? 489
12. What is the most common cause of proptosis in an adult? 489
13. Which metastatic lesion to the orbit is classically associated with enophthalmos? 489
14. What is the most common primary ocular malignancy in a child and in an adult? 489
15. What key clinical and imaging features distinguish an optic nerve glioma from an optic nerve meningioma? How do they differ in appearance from optic neuritis? 490
16. Hearing loss is classified into what two major subtypes? 491
17. What are the types of tinnitus, and how are they subcategorized? 491
18. Cholesteatoma is a “pearly white” mass seen in the middle ear on otoscopic examination. What is a cholesteatoma? 491
19. What neoplasms occur in the jugular foramen? 492
20. Unilateral middle ear fluid in an adult should trigger the search for what lesion? 492
Bibliography 493
VIII Musculoskeletal Imaging 495
45 Imaging of Extremity Trauma 497
1. What is the role of radiography, computed tomography (CT), and magnetic resonance imaging (MRI) in the evaluation of extremity trauma? 497
2. How are fractures evaluated with radiography? 497
3. What are imaging features that help distinguish between acute and chronic fractures on radiography, CT, and MRI? 497
4. Define the following terms: closed fracture, open fracture, avulsion fracture, comminuted fracture, intraarticular fracture, occult fracture, pathologic fracture, fracture displacement, and fracture angulation. 497
5. What is a stress fracture? What two types may occur? 498
6. What is the difference between dislocation and subluxation of a joint? 498
7. What are some of the complications of fractures? 498
8. What is an os acromiale? 498
9. Describe type I, II, and III acromioclavicular (AC) separation. 498
10. What are the radiographic features of anterior shoulder joint dislocation on an anteroposterior view? 498
11. What are Hill-Sachs fracture and Bankart fracture? 498
12. What radiographic signs are associated with posterior shoulder dislocation? 499
13. What is pseudosubluxation of the humerus? 499
14. What are the “posterior fat pad” sign and the “sail” sign in the elbow? 500
15. Describe a Monteggia fracture and its associated finding. 500
16. Describe a Galeazzi fracture and its associated finding. 500
17. Which carpal bone gets fractured the most often? 500
18. What is the “Terry Thomas” sign? 500
19. Define dorsal intercalated segmental instability (DISI) and volar intercalated segmental instability (VISI). 500
20. What are the four stages of perilunate instability? 500
21. What is a Stener lesion? 501
22. Match the following fractures with the radiographic images in Figure 45-5. 501
23. Which is more common, anterior or posterior dislocation of the hip joint? 501
24. What is a Segond fracture? 501
25. What is a bipartite patella? 501
26. What is a tibial plafond fracture? 501
27. What is Böhler’s angle? 501
28. Match the following fractures with the radiographic images in Figure 45-6. 501
Bibliography 503
46 Imaging of Spinal Trauma 504
1. What are the roles of radiography, computed tomography (CT), and magnetic resonance imaging (MRI) in the evaluation of spinal trauma? 504
2. Describe how to interpret a lateral cervical spine radiograph. 504
3. What is a swimmer’s view? 504
4. What is the three column concept of the spine? 504
5. What is the difference between compression and burst fractures? 504
6. Name some hyperflexion and hyperextension spinal injuries. 504
7. Describe a Jefferson fracture and its mechanism of injury. 504
8. Describe three different types of odontoid process (also known as dens) fractures. 504
9. What is an os odontoideum? 505
10. What is a hangman’s fracture? 505
11. What is a flexion teardrop fracture? What is its prognostic significance? 505
12. What is an extension teardrop fracture, and how does it differ from the flexion teardrop fracture? 505
13. What is a clay shoveler’s fracture? 507
14. What is the difference between unilateral and bilateral interfacetal dislocations? 507
15. What types of spinal fractures are considered to be unstable? 507
16. What is the “reverse hamburger bun” sign? 507
17. What is a Chance fracture? 507
18. What is a “Scotty dog”? 508
19. What is spondylolysis? 508
20. Describe spondylolisthesis and its grading method. 508
Bibliography 509
47 Imaging of Nontraumatic Spinal Disorders 510
1. What are the indications, advantages, and disadvantages of radiography, computed tomography (CT), and magnetic resonance imaging (MRI) in the evaluation of the spine? 510
2. Define scoliosis, lordosis, and kyphosis. 510
3. What is the most common cause of scoliosis? 510
4. What is the Cobb angle? 510
5. What is a limbus vertebra? 510
6. What is a butterfly vertebra, a hemivertebra, and a block vertebra? 510
7. What is a transitional vertebra? 510
8. List the imaging features of spinal degenerative disease. 513
9. What is a Schmorl’s node? 514
10. What are Modic changes of the vertebral endplates? 514
11. What terms are used to describe the different types of disc extension beyond the vertebral body margin? 514
12. Other than degenerative disc pathology, what other factors commonly contribute to neural foraminal narrowing and spinal canal stenosis? 516
13. What nerve roots exit the C3-4, C7-T1, T3-4, and L5-S1 neural foramina? 517
14. What nerve root may be impinged by a right paracentral disc herniation at L5-S1? 517
15. What nerve root may be impinged by a left foraminal or extraforaminal disc herniation at L3-4? 517
16. What is failed back syndrome? What is the best way to evaluate affected patients? 517
17. What is spondylolisthesis and spondylolysis? Name the two major causes and the key imaging findings. 518
18. What is the “inverted Napoleon hat” sign? 518
19. What is OPLL? 518
20. What is DISH? 518
21. What are three radiographic criteria for the diagnosis of DISH? 518
22. What is the difference between an osteophyte, a syndesmophyte, and an enthesophyte? 520
23. What is Scheuermann’s disease? 520
24. What is Baastrup’s disease? 520
25. What is myelofibrosis? 520
26. What types of nondegenerative arthritides may affect the spine? 520
27. What is Kummel disease? 522
28. What is Paget’s disease of bone? 522
Bibliography 523
48 Imaging of Metabolic Bone Disease 524
1. What is osteoporosis? How does it differ from osteopenia, osteomalacia, and osteosclerosis? 524
2. What is a DXA scan? How is bone mineral density (BMD) calculated? 524
3. What sites of the skeleton are routinely assessed on a DXA scan? 524
4. What are the World Health Organization (WHO) diagnostic thresholds for normal bone mineral density, osteopenia, and osteoporosis? 524
5. What is disuse osteoporosis? When can it be seen? What disease state can it potentially mimic? 524
6. What are the radiographic findings of hyperparathyroidism? 524
7. What is renal osteodystrophy? What is a Looser zone fracture? 524
8. What is a brown tumor? 525
9. What are the skeletal manifestations of acromegaly? 525
10. What is the difference between metastatic calcification and dystrophic calcification? 525
11. What is tumoral calcinosis? 527
Bibliography 527
49 Imaging of Arthritis 528
1. What kinds of joints exist? 528
2. What are the advantages and disadvantages of the common imaging modalities used to evaluate arthritis? 528
3. What are the radiographic features that are assessed in the evaluation of arthritis? 528
4. What are the characteristic imaging findings of osteoarthritis (OA)? 528
5. What are some differences between OA and rheumatoid arthritis (RA)? 528
6. What are some common imaging features of RA? 528
7. Which joints in the hand and wrist are usually affected by RA? 529
8. What are subchondral cysts? 530
9. Does RA affect larger joints? 530
10. What is erosive (inflammatory) OA? 530
11. How do the seronegative spondyloarthropathies differ from RA? 530
12. What are the main crystal deposition disorders? 530
13. What are the imaging findings in gout? 531
14. What is chondrocalcinosis? 531
15. Is chondrocalcinosis synonymous with CPPD? 531
16. What is pseudogout? 531
Bibliography 533
50 Imaging of Musculoskeletal Infection 534
1. What is the role of imaging in the diagnosis of musculoskeletal infection? 534
2. What imaging modalities are used in diagnosing musculoskeletal infections? 534
3. What is the role of US in the diagnosis of musculoskeletal infection? 534
4. What is the role of nuclear medicine techniques in the diagnosis of musculoskeletal infection? 534
5. In general, what is the first-line imaging modality used to diagnose musculoskeletal infection? 534
6. Define osteomyelitis, cellulitis, fasciitis, myositis, pyomyositis, phlegmon, and abscess. 534
7. What is the clinical significance of an abscess? 534
8. Define Brodie abscess, sequestrum, involucrum, cloaca, and sinus tract. 534
9. What is the first-line modality in the diagnosis of acute osteomyelitis? 535
10. What are the primary findings of acute osteomyelitis on radiographs? 535
11. What is the most specific finding of acute osteomyelitis on radiographs? 535
12. What differential diagnoses may simulate the appearance of acute osteomyelitis on radiographs? 535
13. Is radiography sensitive for the detection of acute osteomyelitis in the early clinical setting? 535
14. If radiographs are positive for acute osteomyelitis, is there a role for MRI? 535
15. If radiographs are negative for acute osteomyelitis, is there a role for MRI? 535
16. What are the MRI findings of osteomyelitis? 535
17. Is bone marrow edema specific for the diagnosis of acute osteomyelitis? 536
18. What can help establish the diagnosis of acute osteomyelitis on MRI? 536
19. What are the routes of spread of infection that involve bone? 536
20. How does the MRI appearance of acute osteomyelitis differ if the source of infection is hematogenous? 536
21. How does the diagnosis of osteomyelitis differ in patients with Charcot arthropathy (neuropathic joint)? 537
22. Is intravenous contrast material necessary for the diagnosis of acute osteomyelitis by MRI? 537
23. What is the role of intravenous contrast material in the diagnosis of soft tissue infection? 537
24. What imaging study is ordered in a patient with suspected septic arthritis? 537
25. Are there any imaging findings that are suggestive of septic arthritis? 538
26. What is necrotizing fasciitis? 538
27. What is the radiographic and MRI appearance of infectious spondylitis? 538
28. What is Pott’s disease? 538
29. What is the significance of unilateral sacroiliitis? 539
Bibliography 539
51 Imaging of Musculoskeletal Tumors 540
1. What radiographic features are considered when evaluating a suspected bone tumor? 540
2. How do cartilage tumor matrix and neoplastic bone matrix differ? 540
3. Which imaging study should be ordered first for the evaluation of a suspected musculoskeletal tumor? 540
4. What is the role of magnetic resonance imaging (MRI) in the evaluation of musculoskeletal tumors? 540
5. What is the role of intravenous contrast material in MRI of musculoskeletal tumors? 540
6. What are some musculoskeletal tumor features evaluated with MRI? Can MRI be used to distinguish between benign and malignant tumors? 540
7. What is the role of computed tomography (CT), ultrasonography (US), bone scintigraphy, and positron emission tomography/computed tomography (PET/CT) in the evaluation of musculoskeletal tumors? 540
8. Which classification system is used for soft tissue and bone tumors? 542
9. What is the staging system adopted by the Musculoskeletal Tumor Society, and what three features form the basis of this staging system? 542
10. What is the most common malignant tumor involving the skeleton? 542
11. What are the most common primary neoplasms that metastasize to osseous structures? 542
12. Which tumors can give rise to lytic, expansile, or “blown-out” osseous metastases? 542
13. What is the most common primary malignant bone tumor in adults? 542
14. If the diagnosis of multiple myeloma is suspected, what radiographic evaluation should be performed? 542
15. What is the second most common primary bone tumor after multiple myeloma? 542
16. Which primary bone tumors tend to involve the epiphysis most commonly? 542
17. Which primary bone tumors tend to involve the diaphysis most commonly? 544
18. Which type of tumor can manifest with bone pain, swelling, fever, and increased erythrocyte sedimentation rate (ESR), mimicking an infection? 544
19. Which of the following has an increased incidence of skeletal malignancy: high-dose radiation therapy, bone infarction, Paget’s disease of bone, or chronic osteomyelitis? 544
20. Where do sarcomas most commonly metastasize? 544
21. What is the most common benign skeletal neoplasm? 544
22. Which clinical and radiographic features suggest malignant degeneration of an osteochondroma? 544
23. What is the most common benign bone tumor of the hand? Where else may these lesions occur, and what are the features of malignant transformation? 544
24. Which primary bone tumor has the characteristic history of pain at night that is relieved by aspirin? 545
25. What is fibrous dysplasia? 545
26. What is a bone island? 545
27. What is the most common location for a skeletal hemangioma? 545
Bibliography 546
52 MRI of the Shoulder 547
1. Describe the imaging planes used for evaluating the shoulder on a magnetic resonance imaging (MRI) examination. How should the patient be positioned in the scanner? 547
2. Name the four muscles of the rotator cuff and their sites of attachment. What is the normal MRI appearance of the tendons? 547
3. What are the symptoms of rotator cuff pathology? Which rotator cuff tendon is most commonly torn? 547
4. Define shoulder impingement syndrome. 547
5. Describe the MRI findings of rotator cuff pathology. 547
6. What is an os acromiale? 547
7. What is the glenoid labrum, and what are the symptoms of a labral tear? 547
8. When should shoulder MR arthrography be performed? 547
9. What are the MRI findings of a labral tear? 547
10. What is a paralabral cyst, and what is its clinical significance? 548
11. Define glenohumeral instability. 548
12. Describe the MRI findings seen with anterior shoulder instability. 548
13. What is a SLAP lesion? 549
14. Describe the nerve entrapment syndromes that can occur around the shoulder. 550
15. What is Parsonage-Turner syndrome? 550
16. Describe the clinical and MRI findings of adhesive capsulitis. 550
Bibliography 550
53 MRI of the Elbow 551
3. What is the common flexor tendon, and where does it originate? 551
4. What is the common extensor tendon, and where does it originate? 551
5. What is the function of the ulnar collateral ligament (UCL), and what are its components? 551
6. Which component of the UCL is the primary restraint to valgus stress? 551
7. What are the three components of the lateral ligament complex of the elbow? 552
8. What is the importance of the LUCL? 552
9. What structure passes through the cubital tunnel? 552
10. What are the borders of the cubital tunnel? 552
11. What are common indications for MRI of the elbow? 552
12. What are common indications for MR arthrography of the elbow? 552
13. What other imaging modalities are utilized for evaluation of the elbow? 553
14. What is the MRI appearance of tendinopathy? 553
15. What is the MRI appearance of a tendon tear? 553
16. What is “tennis elbow,” and what are its causes? 553
17. What is “golfer’s elbow,” and what are its causes? 553
18. What is the most frequent cause of a distal biceps tendon tear? 553
19. What is a ganglion cyst? Where do they occur at in the elbow? 554
20. What are the causes and MRI appearance of olecranon bursitis? 554
21. What is cubital tunnel syndrome, and what are its causes? 554
22. What ligament is the most commonly injured by the throwing athlete? 554
Bibliography 555
54 MRI of the Hand and Wrist 556
1. What are some common indications for performing magnetic resonance imaging (MRI) of the hand and wrist? 556
2. What is the anatomy of the hand and wrist? 556
3. What is meant by the term “intercalated segment”? 556
4. What is ulnar variance? 556
5. What is the normal MRI appearance of the wrist? 556
6. What are the boundaries and contents of the carpal tunnel? 557
7. What are the boundaries and contents of the ulnar tunnel (Guyon’s canal)? 557
8. What is carpal tunnel syndrome (CTS)? 557
9. What is the MRI appearance of CTS? 558
10. What is ulnar tunnel syndrome (UTS)? 558
11. What is the MRI appearance of traumatic injuries to the TFCC? 558
12. What is the MRI appearance of degenerative injuries to the TFCC? 558
13. What is the MRI appearance of tendon degeneration, tendon tear, and tenosynovitis? 558
14. What is de Quervain’s disease? 559
15. What is intersection syndrome? 559
16. What is wrist instability? 559
17. What is the MRI appearance of tears of the scapholunate and lunotriquetral ligaments? 559
18. What is the role of MR arthrography for evaluation of wrist ligamentous injuries? 559
19. What are the MRI findings of fractures? 560
20. What is the role of MRI in the evaluation of scaphoid fractures? 560
21. What is Kienböck’s disease? 560
22. What is a ganglion cyst? 560
23. What is a fibrolipomatous hamartoma (FLH)? 561
24. What is “gamekeeper’s thumb”? 561
25. What is a Stener lesion? 561
Bibliography 562
55 MRI of the Hip 563
1. What is the basic normal anatomy of the hip? 563
2. What are the indications for magnetic resonance imaging (MRI) of the hip? 563
3. What is the proper MRI technique used for the evaluation of hip pain? 563
4. When should intravenous contrast material be administered for hip MRI? 563
5. What is the significance of the bone marrow edema pattern in the proximal femur? 563
6. What is AVN of the hip? 563
7. What is the role of MRI in the diagnosis of the femoral head AVN? 563
8. What is the MRI appearance of hip osteonecrosis? 564
9. What is ITOH? 564
10. What are the imaging features of ITOH? 564
11. What are the most common types of radiographically occult hip fractures? 564
12. Why is MRI important in the early diagnosis of occult proximal femoral fractures? 564
13. How are stress and insufficiency fractures diagnosed on MRI? 565
14. What is the differential diagnosis of cystic lesions around the hip joint? 566
15. What causes a paralabral cyst, and how can MRI help determine if a juxtaarticular cyst is paralabral? 567
16. What is femoroacetabular impingement (FAI), and why is it important to recognize? 567
17. How does MRI help in evaluation of patients with FAI? 567
18. What are the causes of greater trochanteric pain syndrome? 567
Bibliography 568
56 MRI of the Knee 570
1. What sequences are typically included in a routine magnetic resonance imaging (MRI) examination of the knee? 570
2. Describe the clinical presentation of meniscal injury. What part of the meniscus is most commonly torn? 570
3. What is the appearance of the normal menisci on MRI? 570
4. What are the criteria for diagnosing a meniscal tear on MRI? 570
5. Describe the common types of meniscal tears. 570
6. What is a parameniscal cyst, and what is its significance? 570
7. What is a discoid meniscus, and what is its significance? 573
8. Describe the anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) attachment sites. 573
9. Describe the MRI appearance of ACL rupture (i.e., tear). 573
10. What are some secondary MRI findings of ACL rupture? 573
11. What comprises the medial collateral ligament (MCL)? 573
12. What comprises the lateral collateral ligament (LCL) complex? 573
13. How is ligamentous injury graded on MRI? 573
14. What structures are present at the posterolateral corner of the knee, and why are they important? 573
15. What is O’Donoghue’s “unhappy triad”? 573
16. Describe findings of transient lateral patellar dislocation. 573
17. Describe the MRI findings of patellar tendinitis. 574
18. What is osteochondritis dissecans (OCD)? 574
19. What are the MRI features of an unstable OCD fragment? 574
20. What is subchondral insufficiency fracture of the knee? Describe its MRI appearance. 574
21. What is pes anserinus? 574
22. Where is a popliteal (Baker) cyst located, and what is its significance? 574
Bibliography 576
57 MRI of the Foot and Ankle 577
1. What are the compartments of the ankle joint, and what structures do they contain? 577
2. Which bones form the hindfoot, midfoot, and forefoot? 577
3. What is the MRI appearance of tendon abnormalities? 577
4. What is the MRI appearance of Achilles tendon rupture? 578
5. Which ligaments are injured during ankle inversion? 578
6. Which ligaments are injured during ankle eversion? 578
7. How does an osteochondral lesion occur? 578
8. What are the most common sites of avascular necrosis in the ankle? 579
9. What is tarsal coalition, and where does it occur? 579
10. Describe the MRI appearance of plantar fasciitis. 579
11. What is plantar fibromatosis? 579
12. What is a Morton’s neuroma, and where does it occur? 580
13. What is the tarsal tunnel, and what does it contain? 580
14. What is tarsal tunnel syndrome? 580
15. What is the MRI appearance of stress fractures in the foot? 580
16. What is sinus tarsi syndrome? 580
Bibliography 581
IX Ultrasonography 583
58 Obstetric Ultrasonography in the First Trimester 585
1. What are the indications for ultrasonography (US) in the first trimester? 585
2. What is typically evaluated during obstetric US in the first trimester? 585
3. Describe the US features of a normal gestational sac. 585
4. Describe the US features and significance of an abnormal gestational sac. 585
5. When should a yolk sac and an embryo be visible by US? 585
6. What are the US findings of an abnormal yolk sac? 585
7. At what point should embryonic cardiac activity be detected on US? 586
8. What is the first trimester nuchal translucency (NT) measurement? 586
9. Describe the first trimester US features of twin gestations. 587
10. List seven causes of vaginal bleeding in the first trimester. 587
11. Name three possible causes of a positive serum β-HCG level and an empty uterus on US. 587
12. Name six types of early pregnancy complications, and describe their US appearances. 587
13. What is an ectopic pregnancy? 587
14. Who is at increased risk for an ectopic pregnancy? 589
15. What is the classic clinical presentation of an ectopic pregnancy? 589
16. List four possible US findings associated with an ectopic pregnancy. 589
17. What is a pseudogestational sac? 589
18. What is a heterotopic pregnancy? 589
19. What is a molar pregnancy? 589
20. What is the US appearance of a molar pregnancy? 589
Bibliography 591
59 Obstetric Ultrasonography in the Second Trimester 592
1. What are the indications for obstetric ultrasonography (US) in the second (and third) trimester? 592
2. List the basic components of a standard (level 1) second trimester US examination. 592
3. How is gestational age determined in the second trimester? 592
4. How is the amniotic fluid volume measured? 592
5. What is oligohydramnios? 592
6. What is polyhydramnios? 592
7. How is cervical incompetence evaluated sonographically? 593
8. Describe the various types of placenta previa. 593
9. Differentiate the various types of placenta accreta. 594
10. Does US have a role in assessing second (and third) trimester maternal pain and bleeding? 594
11. How many vessels are in the umbilical cord? 595
12. Why is the diameter of the fetal lateral ventricle measured during routine second trimester US? 595
13. What is the importance of the fetal cisterna magna measurement during routine second trimester US? 595
14. Describe the US features of anencephaly. 595
15. What is the purpose of evaluating the fetal lips on US? 595
16. Can US differentiate spina bifida in utero? 595
17. Are there secondary intracranial signs of open spina bifida on US? 596
18. How many anomalies can be detected on the second trimester US four-chamber heart view? 596
19. How is fetal pulmonary hypoplasia assessed on US? 596
20. What is the most common intrathoracic/extracardiac fetal anomaly? 596
21. Describe the US features of an omphalocele versus gastroschisis. 596
22. When should the urinary bladder be visible on US? 598
23. What is the significance of finding dilated bilateral renal pelves on routine second trimester US? 598
24. How is IUGR diagnosed sonographically? 599
25. The estimated fetal weight (EFW) for a fetus at 34 weeks gestation on US is greater than the ninetieth percentile. What are the potential complications at delivery? 599
26. When should the umbilical artery systolic to diastolic (S/D) ratio be measured? 599
27. Describe the ultrasound features of fetal hydrops. 599
28. List the complications that can be associated with a twin gestation. 599
29. What are the ultrasound features of a monochorionic diamniotic twin-to-twin transfusion syndrome (TTTS)? 599
30. Name seven “soft” ultrasound markers of potential fetal aneuploidy. 601
Bibliography 601
60 Advanced Fetal Ultrasonography and Therapy 602
1. What is a “level II” obstetric ultrasound examination, and what elements of fetal anatomy are included? 602
2. What is a “detailed extended” obstetric ultrasound examination? 602
3. What are the common nonemergent indications to perform a detailed extended obstetric ultrasound study? 603
4. What is the significance of an elevated maternal serum AFP level? 604
5. What is the significance of size-date discrepancies? 604
6. A detailed extended obstetric ultrasound examination can take considerably longer than a level II study. What are the safety elements of obstetric US? 604
7. Why does the TI have a letter after it? 605
8. What values of TI and MI are recommended for fetal US studies? 605
9. What constitutes fetal therapy? 605
10. What are the major fetal anomalies for which diagnostic and therapeutic techniques are available? 605
11. How are fetuses with open spina bifida and myelomeningocele (MMC) evaluated? 606
12. What is the therapeutic approach to treatment of fetuses with spina bifida and MMC? 608
13. What are the imaging requirements for thoracic and lung abnormalities? 609
14. What specific imaging is performed for fetal pleural effusions? 609
15. What are the therapeutic strategies for fetal pleural effusions? 609
16. How are fetal lung masses evaluated sonographically? 610
17. What are the therapeutic strategies for treatment of lung masses? 612
18. What is CHAOS, and how is it diagnosed and treated? 612
19. How is the diagnosis of a congenital diaphragmatic hernia (CDH) made sonographically, and what features and measurements are important? 613
20. How is CDH treated? 614
21. How are fetuses with neck masses diagnosed and treated? 614
22. What is involved in the evaluation of sacrococcygeal teratoma (SCT), and how is it treated? 615
23. What is lower urinary tract obstruction (LUTO) in a fetus, and how is it diagnosed and treated? 616
24. What are the important ultrasound findings in evaluation of abnormalities in twins, and what are the treatment methods? 616
25. What is the role of US for conjoined twins? 621
Acknowledgment 622
Bibliography 622
61 Neck Ultrasonography 624
1. What is the basic normal anatomy and sonographic imaging appearance of the thyroid gland? 624
2. What is the basic normal anatomy and sonographic imaging appearance of the parathyroid glands? 624
3. What is the basic normal anatomy and US imaging appearance of cervical lymph nodes? 624
4. What are the indications for US of the thyroid gland, parathyroid glands, and neck lymph nodes? 625
5. What is a thyroid goiter? 626
6. What is chronic lymphocytic (Hashimoto’s) thyroiditis? 626
7. What is Graves’ disease? 627
8. How good is US for detecting thyroid abnormalities? 627
9. What proportion of focal thyroid nodules are neoplastic? 628
10. What types of thyroid cancer are there? 628
11. How is US useful to determine which thyroid nodules warrant FNA? 628
12. What is the most common congenital anomaly of the neck? 631
13. What are some parathyroid gland pathologies that may occur? 632
14. What are some causes of cervical lymphadenopathy? 634
15. What imaging features may be useful to distinguish benign from malignant lymph nodes? 634
Bibliography 637
62 Abdominal Ultrasonography 638
1. List some of the most common indications for abdominal ultrasonography (US). 638
2. What is the sonographic appearance of the liver? 638
3. How are the hepatic veins and portal veins differentiated on US? 638
4. What is the most common cause of increased hepatic echogenicity? 638
5. Describe the US appearance of acute hepatitis. 638
6. Name and describe the US appearance of common benign and malignant focal hepatic lesions. 638
7. Describe the US appearance of a target lesion in the liver and its significance. 638
8. What are the sonographic features of cirrhosis? 638
9. What is the appearance of gallstones on US? 638
10. What is the “wall-echo-shadow” sign? 641
11. Can tumefactive sludge and gallbladder polyps be differentiated from gallstones sonographically? 641
12. Name possible causes of gallbladder wall thickening. 641
13. Describe the US appearance of adenomyomatosis. 641
14. What is the significance of gallbladder wall calcification? 641
15. How does acute cholecystitis manifest on US? 641
16. Name four complications of cholecystitis and their appearance on US. 642
17. Can US differentiate between benign and malignant gallbladder polypoid lesions (polyps)? 642
18. Describe the US appearances of gallbladder carcinoma. 643
19. What is the normal caliber of the extrahepatic bile duct? 643
20. List four possible causes of biliary obstruction. 643
21. What is the normal sonographic appearance of the pancreas? 643
22. Does US have a role in evaluating acute pancreatitis? 643
23. What are the sonographic features of pancreatic adenocarcinoma? 643
24. Can the two main cystic neoplasms of the pancreas be differentiated sonographically? 643
25. What is the normal sonographic appearance of the kidney? 644
26. Does US have a role in evaluating pyelonephritis? 644
27. What are the US findings of urinary obstruction? 644
28. What is the US appearance of renal calculi? 644
29. Describe the various appearances and management of renal cysts detected sonographically. 644
30. Name four diseases associated with renal cysts and their extrarenal manifestations. 645
31. Renal US detects a 3-cm hypoechoic solid mass in the right kidney of a 57-year-old man with hematuria. What is the most likely diagnosis? 645
32. Is it possible to differentiate AMLs and RCCs sonographically? 645
33. What is the significance of increased renal echogenicity on US? 645
Bibliography 646
63 Musculoskeletal Ultrasonography 647
1. What are some benefits of ultrasonography (US) for musculoskeletal applications? 647
2. What are the common indications for musculoskeletal US? 647
3. When is musculoskeletal US not utilized? 647
4. How are images oriented in musculoskeletal US? 647
5. What are the commonly used transducers in musculoskeletal US? 647
6. What is anisotropy, and how can this be used to differentiate among soft tissue structures? 647
7. What is the normal sonographic appearance of various soft tissues (skin, subcutaneous fat, fascia, cortical bone, hyaline cartilage, fibrocartilage, and muscle)? 648
8. What is the normal echotexture of tendons and ligaments? 649
9. What is the normal echotexture of peripheral nerves? 649
10. Which soft tissue masses can be diagnosed on US? 650
11. How can US differentiate between a ganglion cyst and a bursa? 650
12. How can a ganglion cyst be differentiated from a parameniscal cyst on US? 651
13. What is the sonographic appearance of a lipoma? 651
14. What is an angiolipoma? 651
15. What is fat necrosis? 651
16. What are the sonographic characteristics of a PNST? 652
17. What is the sonographic appearance of a GCTTS? 652
18. When should a soft tissue mass detected on US be referred for MRI? 652
19. What is the appearance of a hematoma on US? How should hematomas be followed up? 652
20. Describe the sonographic appearance of rotator cuff tendon pathology on US. 652
21. What is the accuracy of US in the diagnosis of rotator cuff tears? 653
22. How is dynamic imaging useful in US? 653
23. What is the sonographic appearance of calcific tendinosis? 654
24. What is the sonographic appearance of ligament pathology? 655
25. What is the sonographic appearance of musculoskeletal infection? 655
26. What are some common artifacts seen in musculoskeletal US? 656
27. How is carpal tunnel syndrome diagnosed on US? 657
Bibliography 657
64 Vascular Ultrasonography 658
1. List some of the most common indications for vascular ultrasonography (US). 658
2. How is vascular flow assessed with US? 658
3. What information can be obtained from the spectral Doppler waveform of a vessel? 658
4. How does spectral Doppler US detect vascular stenosis? 658
5. Describe the normal spectral Doppler waveform in a low-resistance artery. 658
6. Describe the normal spectral Doppler waveform in a high-resistance artery. 658
7. Describe the normal spectral Doppler waveform in a vein. 659
8. How is extremity deep vein thrombosis diagnosed sonographically? 659
9. Can US differentiate between acute and chronic deep vein thrombosis? 659
10. How is venous insufficiency evaluated sonographically? 660
11. Name the common indications for carotid artery US. 660
12. How are the extracranial carotid arteries evaluated sonographically? 661
13. What are the sonographic criteria for diagnosing extracranial carotid artery stenosis? 661
14. Define the carotid artery “string” sign. 662
15. Can US detect subclavian steal syndrome? 662
16. Is there a role for US in evaluating abdominal aortic aneurysms (AAAs)? 662
17. What is the role of US in diagnosing renovascular hypertension? 662
18. What is the role of vascular US in evaluating renal transplants? 662
19. Describe the normal hepatic spectral Doppler waveforms. 662
20. What various vascular complications can be detected with color spectral Doppler imaging of the liver? 662
21. When and how should US be used to evaluate a transjugular intrahepatic portosystemic shunt (TIPS)? 663
22. What are the ultrasound features of an arteriovenous fistula (AVF)? 664
23. How is a pseudoaneurysm diagnosed sonographically? 665
24. Can US be used to treat pseudoaneurysms? 666
Bibliography 667
X Interventional Radiology 669
65 Patient Sedation and Pain Management 671
1. What is the purpose of sedation and pain management during an interventional radiology procedure? 671
2. What is the difference between analgesia and anesthesia? 671
3. What is the difference between anxiolysis and amnesia? 671
4. What capabilities should the patient maintain during conscious sedation? 671
5. Describe the levels of patient sedation. 671
6. List the details that should be included in the presedation evaluation of a patient. 671
7. How long should a patient typically fast before undergoing conscious sedation? 671
8. The physical status of a patient is often measured on a 6-point scale, known as the American Society of Anesthesiologists (ASA) Physical Status (PS) classification. Describe this scale. 671
9. Commonly, conscious sedation is administered by the provider (e.g., interventional radiologist) with patient monitoring provided by a qualified nurse. What patient factors should influence a provider to consider consulting an anesthesiologist to administer conscious sedation? 671
10. What patient factors must be monitored during conscious sedation? 672
11. What equipment must be present when administering conscious sedation to a patient? 672
12. What pharmacologic agents are commonly used for patients undergoing conscious sedation? What is their reversal agent? 672
13. What are the usual effects of benzodiazepines? 672
14. What pharmacologic agents are commonly used for pain control? What is their reversal agent? 672
15. What are the typical effects of opiates? 672
16. What pharmacologic agent used for pain control is contraindicated in patients taking a monoamine oxidase (MAO) inhibitor? 672
17. What are the strategies to manage a patient who has a known hypersensitivity to iodinated contrast material? 672
18. List possible options for the management of an acute vasovagal reaction. 672
19. What is the basic life support sequence of steps for patient resuscitation? 672
20. Describe the management of acute hypotension. 672
21. List possible options for the management of an acute hypertensive crisis. 673
22. How is acute pulmonary edema managed? 673
23. Describe the immediate options for management of an anaphylactic reaction. 673
24. Describe the immediate options for management of acute laryngeal edema. 673
25. Describe the immediate options for management of bronchospasm. 673
26. What are possible options for the management of generalized urticaria? 673
Bibliography 673
66 Equipment, Terms, and Techniques in Interventional Radiology 674
1. What are the characteristics of a diagnostic catheter? 674
2. What is the difference between Cobra 1, Cobra 2, and Cobra 3 catheters? 675
3. What is a French? What is a gauge? 675
4. What are the two general categories of stents? How do they differ? 675
5. How is a balloon-expandable stent deployed? 675
6. What two materials are used to make self-expandable stents? 675
7. How do woven Elgiloy and nitinol self-expandable stents differ? 675
8. What is nitinol? 676
9. What do the terms hoop strength, chronic outward force, and radial resistive force mean? 676
10. What is a sheath? 676
11. What is a guiding catheter? 676
12. What is an up-and-over sheath? 676
13. Explain the Trojan horse technique. 676
14. What are the defining characteristics of guidewires? 676
15. What is an exchange-length wire? How long does it have to be? 677
16. What is a Cope loop? 677
17. What is the origin of the term “stent”? 677
18. What does it mean to “Dotter” a lesion? 678
19. What is a micropuncture set? 678
20. What is the difference between the single-wall and the double-wall technique? 678
21. What are the advantages and disadvantages of a single-wall puncture? 678
22. What is a snare? 678
23. What is a reverse curve catheter? 678
24. What are the different ways to form a Simmons catheter? 679
25. What is a Waltman loop? 679
26. What is “road mapping”? 679
27. How do you select the proper injection rate for an arteriogram? 679
28. What is meant by an injection of “20 for 40”? 679
29. What is a rate rise? 679
30. What is a Hickman catheter? 679
31. What is a PermaCath? 679
32. What is a Medcomp? 679
Bibliography 679
67 Inferior Vena Cava Filters 680
1. What is an inferior vena cava (IVC) filter? 680
2. What are some common indications for IVC filter placement? 680
3. List relative indications for IVC filter placement. 680
4. What is a prophylactic IVC filter? 680
5. What is Virchow’s triad? 680
6. What are absolute contraindications to IVC filter placement? 680
7. What are relative contraindications to IVC filter placement? 680
8. How many PE originate from the lower extremities? 680
9. When would a superior vena cava (SVC) filter be placed? 680
10. Why is a vena cavogram performed before IVC filter placement? 680
11. How is a vena cavogram performed before IVC filter placement? 681
12. What do the renal veins look like on a cavogram? 681
13. Can a cavogram be performed if the patient is allergic to iodinated contrast material or has an elevated creatinine level? 681
14. What common venous anomalies are seen on a cavogram? 681
15. How common is IVC duplication? What does it look like on a cavogram? 681
16. What should be done in a patient with duplicated IVC who needs an IVC filter? 681
17. What are the characteristics of a left-sided IVC? 681
18. What are the characteristics of a circumaortic left renal vein? How common is this anatomic variant? 681
19. Where should a filter be placed in a patient with a circumaortic left renal vein? 681
20. What is a retrievable IVC filter? 681
21. What patients could benefit from a retrievable IVC filter? 681
22. Can patients with an IVC filter still get PE? 682
23. Where in the IVC should the filter be placed, and why? 682
24. What complications are related to IVC filter placement? 682
25. How often does IVC occlusion occur after IVC filter placement? 682
Bibliography 682
68 Image-Guided Percutaneous Needle Biopsy 684
1. What are the major indications for image-guided percutaneous needle biopsy? 684
2. What are the available imaging modalities for IPNB? 684
3. What are the contraindications for percutaneous biopsy? 684
4. What criteria are used to determine whether or not a lesion is amenable to IPNB? 684
5. How effective is percutaneous needle biopsy? 686
6. What patient preparation is necessary prior to percutaneous biopsy? 686
7. What type of anesthesia is used for IPNB? 687
8. What is the difference between fine-needle aspiration (FNA) and core biopsy? 687
9. What is the difference between the single-needle technique and the coaxial needle technique of percutaneous biopsy? 687
10. How does one decide whether to use a percutaneous approach or a bronchoscopic approach to biopsy a lung nodule? 687
11. What are the indications for liver biopsy, and what is the best way to biopsy the liver? 687
12. What are the indications for renal biopsy, and what is the best way to biopsy the kidney? 687
13. What are the complications of percutaneous biopsy? 687
14. What are some factors that increase the risk of pneumothorax following percutaneous biopsy? 689
15. How does one manage an air embolus encountered after percutaneous biopsy? 689
16. How are patients managed after percutaneous biopsy? 690
17. How are biopsy specimens handled? 690
Bibliography 691
69 Advanced Procedures in Interventional Radiology 692
Endovascular Aneurysm Repair (EVAR) 692
1. What is the basic composition of a stent graft? 692
2. Who is at risk for abdominal aortic aneurysm (AAA), and what are the major complications of AAA? 692
3. What is the natural history of AAA, and when is intervention indicated? 692
4. How are most AAAs detected, and what is the role of screening? 692
5. In general, when is endovascular aneurysm repair (EVAR) favored over open surgical repair? 692
6. Describe briefly the traditional open surgical repair of AAA. 692
7. Name some findings on preprocedure imaging of AAA that may preclude a patient from undergoing EVAR. 693
8. What is an endoleak? What are the different types of endoleaks, and how are they treated? 693
9. What follow-up imaging tests do patients treated with EVAR undergo? 693
10. What are some of the complications related to EVAR? 693
11. What are the major studies that have looked at the outcomes of EVAR? 693
12. What are the results of the major EVAR studies? 693
13. What devices are currently commercially available in the United States for EVAR, and how do they differ? 694
14. What advantages will future generations of stent grafts have over ones that are currently available? 694
15. What are advantages of EVAR over traditional open surgical repair? 694
Transarterial Chemoembolization (TACE) 694
16. What is meant by transarterial chemoembolization (TACE)? 694
17. What types of hepatic malignancies can be treated with TACE? 694
18. What is a typical mixture used to perform TACE? 694
19. What is the purpose of ethiodized oil (Ethiodol) in the TACE mixture? 694
20. What types of patients should be considered candidates for TACE? 694
21. How are patients followed after TACE, and when is retreatment indicated? 694
22. What is the typical imaging and clinical workup prior to TACE? 694
23. What is postembolization syndrome? 695
24. What medications are patients typically treated with after TACE? 695
25. What is the major risk factor for hepatic abscess formation secondary to TACE? 695
26. What tumor markers are used to follow HCC? What about metastatic colon cancer? 695
27. What laboratory values are checked when determining candidacy for TACE? 695
28. How can the liver tolerate embolization of the hepatic artery without undergoing infarction? 695
29. What does one look for on follow-up imaging to evaluate the success of a TACE procedure? 695
Radiofrequency Ablation (RFA) 695
30. What is radiofrequency ablation (RFA), and how does it work? 695
31. What characteristics of hepatic lesions are considered treatable by RFA? What are the characteristics of renal lesions treatable by RFA? 695
32. What is the major CT and MR imaging characteristic of a lesion successfully treated with RFA? 695
33. How are patients followed after RFA procedures? 695
34. What subset of patients with renal lesions is best treated with RFA? 695
35. What are complications of RFA? 696
Uterine Fibroid Embolization (UFE) 696
36. What are typical symptoms of uterine fibroids? 696
37. What clinical workup is required before undergoing uterine fibroid embolization (UFE)? 696
38. What imaging is required before UFE? 696
39. How is a patient followed after undergoing UFE? 696
40. What are the risks associated with UFE? 696
41. What are the alternatives to UFE? 696
42. How do symptoms typically respond to UFE? 696
43. Are there any other indications for UFE other than fibroids? 696
44. What type of embolic agent is typically used? 696
45. Is there a correlation between postprocedure pain and clinical outcomes? 696
46. What is a typical analgesia protocol for patients undergoing UFE? 696
47. What are the indications for discharge from the hospital after UFE? 696
48. Describe the vascular anatomy relevant to UFE. 697
49. What is the risk of premature menopause related to UFE? 697
50. Is pregnancy possible after UFE? 697
Bibliography 697
70 Peripheral Arterial Disease Diagnosis and Intervention 699
1. What is the appropriate landmark for a femoral artery puncture? 699
2. If the femoral artery cannot be accessed, what are other options to obtain access for an arteriogram? 699
3. If a brachial approach must be used, is the right or left arm used? 700
4. What are some complications unique to brachial access? 700
5. What is claudication? 700
6. What are the risk factors for PAD and claudication? 700
7. Does the location of leg pain suggest the location of arterial stenosis? 700
8. Why is it important to identify patients with claudication? 700
9. What is the Fontaine classification? 700
10. What is the Rutherford-Becker classification system? 700
11. What are the clinical categories of acute limb ischemia? 700
12. What is the ankle-brachial index (ABI)? 700
13. How is the ABI interpreted? 700
14. What can cause a falsely elevated ABI? 700
15. What is meant by the terms inflow and outflow? 701
16. What are the basic steps in performing an angioplasty procedure? 702
17. What constitutes a technically successful angioplasty? 702
18. What are the complications of angioplasty? 702
19. What are the indications for stenting? 702
20. What constitutes a hemodynamically significant arterial stenosis? 702
21. What is the kissing balloon technique? 702
22. If a wire cannot be passed through the lumen of a vessel because of chronic total occlusion, what techniques may be used to allow for endovascular treatment? 703
23. What is an atherectomy device, and what types of lesions might it be useful for? 703
24. What are the basic principles in performing a thrombolysis procedure? 703
25. In general, how is a thrombolysis procedure performed? 704
26. What is the guidewire traversal test? 704
27. List the contraindications to thrombolysis. 704
28. What is a PVR examination? 704
29. What is Leriche syndrome? 704
30. What is an ACT measurement? 704
31. How are groin pseudoaneurysms managed? 704
32. What are the major pathways of collateral circulation to supply the lower extremities in a patient with known aortic occlusion? 704
Bibliography 705
71 Embolization Techniques and Applications 706
1. Describe embolotherapy and some of its indications. 706
2. What materials are most commonly used for embolization? 706
3. What is Gelfoam, and how is it prepared and delivered? 706
4. How does Gelfoam work, and when is it used? 706
5. What are metallic coils? 706
6. When are coils preferred? 706
7. What happens when coils are the wrong size? 706
8. When are PVA particles used? 706
9. When performing an embolization procedure, why is it always recommended to place a vascular sheath at the access site? 707
10. What is postembolization syndrome? 707
11. How can nontarget embolization be minimized? 707
12. When performing an embolization procedure for an upper GI bleed, what information from the endoscopy report is essential? 707
13. Can a lower GI bleed be treated with empiric embolization? 707
14. In the setting of pelvic trauma or peripartum hemorrhage in a patient with an unstable condition, is superselective embolization always indicated? 707
15. Name some clinical indications for arteriography in patients with pelvic trauma. 707
16. Is empiric embolization indicated in pelvic trauma? 707
17. In bronchial artery embolization for hemoptysis, vigilance for which vessels is imperative? 707
18. Why should coils not be used in the bronchial arteries? 708
19. Why is it necessary to embolize both sides of a pseudoaneurysm, aneurysm, or AVF? 708
20. What should always be placed when absolute ethanol is being used for renal artery sclerosis? 708
21. How is chemoembolization theorized to work? 708
22. What happens when the cystic artery is embolized during hepatic lesion embolization/chemoembolization? 708
23. What happens if the left or right gastric artery is embolized during hepatic chemoembolization? 708
24. What is the significance of gas in the target organ post embolization? 708
25. What findings suggest that postembolization gas is due to infection? 708
26. When is uterine artery embolization (UAE) used in a nonemergent setting? 709
Bibliography 709
72 Biliary and Portal Venous Interventions 710
1. What are the indications for percutaneous transhepatic biliary drainage? 710
2. List the causes of benign and malignant biliary obstruction. 710
3. What is the most commonly encountered biliary ductal anatomy? 710
4. What are some important normal biliary ductal anatomic variants? 710
5. Describe the basic steps required to perform diagnostic percutaneous transhepatic cholangiography. 711
6. Describe the basic steps required to perform percutaneous transhepatic biliary drainage. 712
7. What is the difference between an external biliary drainage catheter and an internal/external biliary drainage catheter? 712
8. When should an internal/external drain be capped? When should this drain be uncapped? 712
9. A patient begins to leak bile around an indwelling biliary drain. Why does this happen, and what can be done to remedy this? 713
10. What are the potential complications associated with percutaneous transhepatic biliary drainage? 713
11. After an initial drainage procedure, what additional management measures may be performed to treat benign biliary obstruction? 713
12. What can be done to manage the treatment of malignant biliary obstruction after initial drainage? 713
13. What does the term isolated ducts mean? What is its significance? 713
14. How does stricture morphology help to differentiate between benign and malignant disease? 713
15. If a histologic diagnosis is required, what methods may be used to obtain a biopsy specimen of the bile ducts? 714
16. When is percutaneous cholecystostomy indicated? 714
17. Name the basic steps involved in performing percutaneous cholecystostomy. 714
18. What are the potential complications associated with percutaneous cholecystostomy? 714
19. How long must a percutaneous cholecystostomy catheter remain within the gallbladder before it can be removed? 714
20. Should a cholecystostomy catheter be placed to external drainage indefinitely? 714
21. When is transjugular liver biopsy indicated and preferred over percutaneous liver biopsy? 714
22. How is transjugular liver biopsy performed? 714
23. What are some clinical signs and symptoms associated with portal hypertension? 714
24. How can one indirectly estimate portal venous pressure to confirm the diagnosis of portal hypertension? 715
25. What are the indications for creating a transjugular intrahepatic portosystemic shunt (TIPS)? 715
26. What are the contraindications to TIPS creation? 715
27. Describe the steps of the TIPS procedure. 715
28. What are the potential complications of TIPS creation? 716
29. What are the short-term and long-term goals of TIPS creation? 716
Bibliography 716
73 Genitourinary and Gastrointestinal Interventional Radiology 717
1. List the indications for percutaneous nephrostomy (PCN) (Figure 73-1). 717
2. What is the indication for emergent PCN? 717
3. What are the important technical factors to consider when performing PCN? 717
4. What is the most common method of visualizing the collecting system for PCN? 717
5. What are the alternative means other than fluoroscopy for visualizing the collection system for PCN? 718
6. Should access for PCN be obtained through the renal parenchyma or directly into the renal pelvis? 718
7. From what approach should PCN be performed? 718
8. Aside from decreasing the chance of bleeding, what are the other benefits of performing PCN through Brödel’s line? 719
9. What imaging modalities can be used to perform a percutaneous drainage of renal or perinephric abscesses? 719
10. What are the possible complications resulting from percutaneous drainage of renal or perinephric abscesses? 719
11. When is percutaneous management of urinary tract calculi preferred over extracorporeal shock wave lithotripsy (ESWL)? 719
12. What is the role of PCN in percutaneous treatment of urinary tract calculi? 719
13. How are calculi removed during percutaneous treatment of the urinary tract? 719
14. What are the indications for ureteral stenting? 719
15. Describe the difference between a double-J ureteral stent and a nephroureteral stent. 719
16. How does a ureteral stent work? 719
17. What are the indications for esophageal stenting? 719
18. What technical complications are associated with esophageal stenting? 719
19. What factors should be considered when selecting the puncture site for percutaneous gastrostomy? 721
20. What is the difference between a G tube, G-J tube, and J tube? 721
21. When are feeding G tubes not the tubes of choice? 722
22. When are small bowel feeding tubes indicated? 722
Bibliography 722
74 Neurointerventional Radiology 724
1. What is the basic normal vascular anatomy of the brain? 724
2. What is the basic normal arterial anatomy of the spinal cord? 724
3. What are the indications and contraindications for cerebral and spinal catheter angiography? 725
4. What types of vascular neurointerventional procedures are available? 726
5. What types of nonvascular neurointerventional procedures are available? 732
6. What are the potential complications of neurointerventional procedures? 732
Bibliography 735
75 Musculoskeletal Interventional Radiology 736
1. What are some common image-guided musculoskeletal interventional procedures? 736
2. What is MR arthrography, and what are its indications? 736
3. What concentration of gadolinium-based contrast material is used when performing MR arthrography? What are the components of the MR arthrogram injectate? 736
4. What will occur if the concentration of gadolinium in the injectate is too high? 737
5. What are the indications for a CT arthrography? What contrast material is used? 737
6. What are the commonly used approaches for injecting the glenohumeral joint? What are the pros and cons of each? 737
7. What imaging modalities can be used to guide joint injections, aspirations, or arthrography? 738
8. What are some benefits of using US to guide musculoskeletal procedures? 738
9. What are some commonly used corticosteroids in musculoskeletal interventions? 738
10. What are some important contraindications to corticosteroid joint injections? 738
11. What are the complications of corticosteroid use in musculoskeletal procedures? 738
12. How is septic arthritis contracted? 738
13. What are the indications for joint aspiration? 738
14. What laboratory tests are ordered when sending aspirated joint fluid for analysis? 738
15. What can you do if you are unable to aspirate any joint fluid? 738
16. What are the most common pathogens in septic arthritis? 739
17. What are some uncommon pathogens seen in septic arthritis? 739
18. What are the indications for a tendon sheath injection, and what are the potential complications? 739
19. What are the indications for an SASD bursal injection? 739
20. What are the potential complications of Baker cyst aspiration? 739
21. Describe the “in plane” and “out of plane” needle approaches in US-guided interventions. 740
22. What techniques can help to increase the conspicuity of a needle during a US-guided procedure? 740
23. What is tendon fenestration, and how is it performed? 741
24. What is platelet-rich plasma (PRP) injection, and why is it used? 741
25. What is calcific tendinosis lavage? 741
26. What is the difference between vertebroplasty and kyphoplasty? 742
27. What are some complications of vertebroplasty or kyphoplasty? 742
28. What is a CT-guided bone biopsy? 742
29. How should a CT-guided bone biopsy be planned? 742
30. What is the most important principle of US-guided soft tissue biopsy? 743
31. When should conscious sedation be used or considered when planning a musculoskeletal intervention? 743
Bibliography 744
XI Nuclear Radiology 745
76 Pet of Oncological Disorders 747
1. What is 18F-fluoro-2-deoxy-2-D-glucose (FDG)? 747
2. What instructions do patients need to prepare for FDG PET imaging? 747
3. What is dual time point (DTP) PET, and what is its potential utility? 747
4. What is the normal pattern of FDG uptake in the body? 747
5. What is the significance of increased FDG uptake in the thyroid gland? 747
6. What is the significance of increased FDG uptake in the bowel? 747
7. What is the significance of increased FDG uptake in the endometrium or adnexa? 748
8. How does hybrid PET combined with structural imaging such as CT or MRI improve diagnostic performance in cancer patients? 748
9. What are the main applications of FDG PET/CT in the oncological setting? 748
10. What is the potential role of FDG PET/MRI in the oncological setting? 748
11. What is the utility of FDG PET to characterize indeterminate lung nodules? 749
12. What are the major causes for false-negative FDG PET findings in cancer patients? 749
13. What are the major causes for false-positive FDG PET findings in cancer patients? 749
14. Is there a specific standardized uptake value (SUV) threshold on FDG PET that can reliably distinguish malignant from benign disease processes? 749
15. What is the utility of FDG PET for disease staging and pretreatment planning of cancer patients? 749
16. Is the lung cancer patient in Figure 76-4 a good surgical candidate? 750
17. What is the role of FDG PET in radiotherapy pretreatment planning? 750
18. How useful is FDG PET for the evaluation of primary and metastatic brain tumors? 750
19. How useful is FDG PET for evaluation of peritoneal spread of tumor? 750
20. What is the utility of FDG PET for response assessment in cancer patients? 750
21. What is the utility of FDG PET for disease restaging of cancer patients? 751
22. What other non-FDG PET radiotracers are available for use in the oncological setting? 751
Bibliography 752
77 Pet of Nononcological Disorders 753
1. What are some applications of 18F-fluoro-2-deoxy-2-D-glucose positron emission tomography/computed tomography (FDG PET/CT) in the nononcological setting? 753
2. What is the role of FDG PET/magnetic resonance imaging (MRI) in the nononcological setting? 753
3. What is the utility of FDG PET in patients with suspected infection? 753
4. What is the utility of FDG PET in patients with nonneoplastic vascular disease? 754
5. What is the utility of FDG PET in patients with nonneoplastic thoracic disorders? 755
6. What is the utility of FDG PET in patients with inflammatory bowel disease (IBD)? 755
7. What is the utility of FDG PET in patients with psoriasis? 755
8. What is the utility of FDG PET in patients with joint disease? 756
9. Is FDG PET useful to evaluate muscle metabolism? 756
10. Is FDG PET useful to evaluate brown fat? 756
Bibliography 756
78 Bone Scintigraphy 758
1. What should patients know about a bone scan? 758
2. What should patients know about an 18F-sodium fluoride (NaF) positron emission tomography (PET) scan? 758
3. What are the normal structures observed on a bone scan? Describe some typical nonmalignant findings in asymptomatic patients. 758
4. Why is a “superscan” associated with a negative prognosis in the patient with prostate cancer shown in Figure 78-2? 758
5. Is there a way to successfully treat a patient with bone pain associated with multiple osteoblastic metastases? 758
6. Figure 78-3 shows a bone scan of a patient complaining of swelling and pain in the distal arm after a recent traumatic event. What is the diagnosis? 759
7. What causes a bone scan that does not show the bones clearly? 759
8. Is a bone scan an appropriate study for a 65-year-old patient with multiple myeloma? 760
9. Does a bone scan that shows a worsened appearance after chemotherapy portend a bad prognosis? 760
10. What are the most common findings on a bone scan that suggest metastatic disease? 761
11. What are the causes of “cold,” or photopenic, defects on bone scans? 762
12. Are three-phase bone scans alone useful for the diagnosis of osteomyelitis? 762
13. What other scans can be used to improve diagnostic accuracy for detecting osteomyelitis? 762
14. Is radiotracer uptake in the lungs normal on a bone scan? 763
15. Can Paget’s disease be distinguished from cancer in the bones on nuclear medicine studies? 763
16. What is the “Mickey Mouse” sign? What is the “Honda” sign? 763
17. Intense radiotracer uptake on a bone scan in multiple joints can be the result of which disorders? 764
18. Can shin splints be differentiated from stress fractures on a bone scan? 764
19. What is the significance of a single rib lesion in a patient undergoing evaluation for metastatic disease from a known primary cancer? 764
20. Which benign bone tumors have increased radiotracer uptake on a bone scan? 764
21. Do bone scans have a role in the evaluation of child abuse? 764
22. Is increased radiotracer uptake in the kidneys a clinically relevant finding on a bone scan? 764
23. What are the causes of liver radiotracer uptake on a bone scan? 764
24. What can cause radiotracer uptake in the muscles as seen on the bone scan in Figure 78-8? 764
25. How does 18F-NaF PET as shown in Figure 78-9 compare to FDG PET and conventional bone scintigraphy for the detection of osseous metastases? 764
Bibliography 765
79 Pulmonary Scintigraphy 767
1. How would you describe and prepare a patient for a ventilation-perfusion (V/Q) scan? 767
2. In what order are imaging studies obtained in the workup of patients with suspected acute pulmonary embolism? 767
3. How do aerosols compare to xenon-133 (133Xe) for use in a ventilation scan? 767
4. What are the normal findings on a V/Q scan? 767
5. What findings are necessary to classify the results of the V/Q scan in Figure 79-2 as “PE present”? 767
6. What are the possible causes of gas trapping on the V/Q scan in Figure 79-3? 769
7. How does a quantitative V/Q scan assist in preparing patients for lung surgery? 769
8. What is the significance of a “triple match” on a V/Q scan and chest radiograph? 769
9. What can cause radiotracer uptake in the liver on the 133Xe ventilation scan in Figure 79-4? 769
10. What are the causes of mismatched perfusion defects on a V/Q scan? 770
11. How can V/Q scans be utilized in the evaluation of chronic PE? 770
12. Why is alpha-1 antitrypsin deficiency the most likely cause of the perfusion scan findings in Figure 79-5? 770
13. Can idiopathic pulmonary fibrosis (IPF) be distinguished from PE on the V/Q scan shown in Figure 79-6? 770
14. Can V/Q scans be performed in pregnant women? 770
15. What does activity in the brain or kidneys imply on a perfusion scan? 770
16. How quickly do perfusion defects associated with pulmonary emboli resolve? 771
17. How are V/Q scans utilized in patients who have had lung transplantation? 772
18. What is a “stripe” sign, and what does it signify on a V/Q scan? 772
19. What are the causes of matched ventilation and perfusion defects on a V/Q scan? 772
20. What are possible causes of unilateral decreases in lung perfusion with relatively preserved lung ventilation on a V/Q scan? 772
Bibliography 773
80 Thyroid, Parathyroid, and Salivary Gland Scintigraphy 774
1. What patient preparation is required before thyroid scintigraphy? 774
2. Which radioisotopes can be used for nuclear medicine imaging of the thyroid gland, and how do they compare physiologically? 774
3. What are normal thyroid scan and iodine uptake results? 774
4. Can a patient with normal thyroid gland 123I uptake still have Graves’ disease? 774
5. What are possible outcomes after 131I therapy for Graves’ disease? 774
6. How is a patient with a hot nodule on thyroid scintigraphy as seen in Figure 80-2 treated for hyperthyroidism? 775
7. Why is a patient with a hot nodule in the thyroid gland more likely to end up euthyroid? 775
8. What are the typical radiation safety precautions that patients must follow after 131I therapy? 776
9. Should the patient with the thyroid scan in Figure 80-3 be treated with 131I? 776
10. What factors affect the likelihood that the thyroid nodule in Figure 80-4 represents thyroid cancer? 776
11. Why can 131I be used to treat thyroid cancer if it appears as a cold nodule on thyroid scintigraphy? 776
12. What foods should be avoided as part of a low-iodine diet? 777
13. What is the general management plan for patients diagnosed with thyroid cancer? 777
14. What does “stunning” mean with regard to 131I scintigraphy? 777
15. What range of doses of 131I is typically recommended for treatment of thyroid cancer in patients with the whole body scans seen in Figures 80-6 and 80-7? 777
16. How do a recombinant human thyrotropin (Thyrogen) scan and treatment work? 778
17. What are some possible causes of a thyroid scan in which there is no uptake or minimal uptake of radiotracer by the thyroid gland? 778
18. Is 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) useful in the management of patients with thyroid cancer? 778
19. What is parathyroid gland scintigraphy used for, and how is it performed? 780
20. What is salivary gland scintigraphy used for, and how is it performed? 780
21. What is the primary finding in the salivary gland study shown in Figure 80-12? 780
Bibliography 782
81 Gastrointestinal and Genitourinary Scintigraphy 783
1. What should patients know about renal scintigraphy, and what preparation should they be given? 783
2. What are the normal findings in renal scintigraphy? 783
3. What are causes of focal areas of decreased flow within a kidney? 783
4. An increase in size of one or both kidneys may be associated with what processes? 783
5. List some causes of a unilaterally small kidney seen on renal scintigraphy. 783
6. Describe potential causes of nonvisualization of a kidney on renal scintigraphy. 783
7. How do processes that decrease the radiotracer activity in both kidneys differ from processes that affect a single kidney? 785
8. How is captopril renal scintigraphy used to evaluate for renal artery stenosis? 785
9. Why are renal scans obtained 1 day after renal transplantation? 785
10. How is ATN differentiated from rejection in renal transplant patients? 785
11. What type of renal scan is used to evaluate for cortical scarring related to pyelonephritis or vesicoureteral reflux? How does it work? 786
12. What are the current uses of liver/spleen scintigraphy? 786
13. What conditions result in a hot quadrate lobe and a hot caudate lobe on a liver/spleen scintigraphy? 786
14. What is the diagnostic pattern of radiotracer activity on a 99mTc red blood cell (RBC) scan in a patient with a hemangioma in the liver? 786
15. What is the best scintigraphic test for the detection of splenic tissue? 787
16. What functions of the hepatobiliary system can be evaluated using iminodiacetic acid (IDA) radiotracers? 787
17. When should cholecystokinin (CCK) or morphine sulfate be used in relation to a hepatobiliary scan? 789
18. What can a gallbladder ejection fraction study show? 789
19. What are the causes of nonvisualization of the gallbladder on a hepatobiliary scan? 789
20. Discuss some causes of false-negative hepatobiliary scan results in the setting of acute cholecystitis. 789
21. What is the “rim” sign, and what does it imply? 790
22. When a biliary leak occurs, where are the possible sites to observe the leak? 790
23. How is biliary atresia differentiated from neonatal hepatitis on hepatobiliary scintigraphy? 791
24. What are the typical findings of a positive gastrointestinal (GI) bleeding scan? 791
25. Contrast the differences between the sulfur colloid scan and the tagged RBC scan for detecting GI bleeding. 791
26. How does a gastric emptying study work? 791
27. What are the normal rates for gastric emptying? 791
28. What physiologic factors normally affect gastric emptying? 792
29. What is a pentetreotide scan and what is it used for? 792
30. What are some available nuclear medicine scans that can be used to detect a pheochromocytoma? 792
Bibliography 794
82 Cardiac Scintigraphy 795
1. How do you prepare a patient for stress myocardial perfusion imaging (SMPI)? 795
2. What are the different types of radiotracers available for stress testing? 795
3. What are the three types of stress tests? 795
4. What are contraindications for an exercise stress test? 795
5. What are the contraindications for pharmacologic vasodilatory and adrenergic agonist stress tests? 796
6. Should patients taking medications that can affect the heart be given stress tests? 796
7. List the conditions under which an exercise stress test should be stopped. 796
8. Which territories are supplied by which coronary arteries? 796
9. What is the implication of a nonreversible (or fixed) defect on SMPI? 796
10. What methods are available to correct for attenuation artifact? 796
11. How do SMPI studies compare with routine stress ECG studies in the evaluation of patients with coronary artery disease (CAD)? 797
12. What is the implication of a reversible (or transient) defect on SMPI? 797
13. Why is transient left ventricular cavity dilation on SMPI a poor prognostic sign? 797
14. How might a left bundle branch block (LBBB) on ECG affect SMPI findings? 798
15. How is a 201Tl resting-redistribution scan performed, and how are the results of a resting-redistribution scan used clinically? 798
16. What is the difference between hibernating and stunned myocardium? 798
17. How is a multiple-gated acquisition (MUGA) scan performed? 799
18. How is a MUGA scan used clinically? 799
19. How does an FDG PET scan of the heart help to evaluate for myocardial viability? 800
20. How does FDG PET scan help with the diagnosis of myocardial sarcoidosis? 800
Bibliography 802
83 Brain Scintigraphy 803
1. What radiotracers are available for functional brain scintigraphy? 803
2. How would you prepare a patient for a brain scan to assess general brain function? 803
3. What are the normal patterns of radiotracer uptake for CBF-SPECT and FDG PET scans? 803
4. What does the FDG PET brain scan pattern in Figure 83-2 represent? 803
5. What does the FDG PET brain scan pattern in Figure 83-3 represent? 803
6. How does an acetazolamide SPECT scan work to determine cerebrovascular disease? 805
7. What is the finding in the FDG PET brain scan shown in Figure 83-4 of a patient with a history of seizures? 805
8. What are the findings in these interictal and ictal CBF-SPECT scans shown in Figure 83-5 of a patient with a history of seizures and prior surgery for a benign brain tumor in the right parieto-occipital region? 805
9. How can one differentiate tumor recurrence from radiation necrosis in the brain using an FDG PET scan? 805
10. What does this brain perfusion scan in Figure 83-7 demonstrate in this patient who was involved in a motor vehicle accident with significant head trauma? 807
11. How is a cerebrospinal fluid (CSF) scintigraphy study performed, and what is it used for? 808
12. What does the CSF scintigraphy study shown in Figure 83-8 demonstrate? 808
13. What does the CSF scintigraphy study shown in Figure 83-9 reveal? 808
14. How is an 123I ioflupane (DaTscan) performed, and what is it used for? 808
15. What is amyloid imaging used for? 808
Bibliography 810
84 Radiopharmaceutical Therapeutic Intervention 811
1. What is the purpose of radiopharmaceutical therapy? 811
2. What is the therapeutic ratio? 811
3. What are the different therapeutic radionuclide emissions? 811
4. Why is radiopharmaceutical therapy useful in thyroid disease? 811
5. What are the potential adverse effects of radiopharmaceutical therapy? 812
6. What are radiation safety precautions? 812
7. How are radiopharmaceutical doses determined? 814
8. What are some commonly used radiopharmaceutical therapies? 814
Bibliography 814
XII Pediatric Radiology 815
85 Pediatric Thoracic Radiology 817
1. What is the embryologic relationship between the lungs and the gastrointestinal tract? 817
2. Describe the histologic stages of lung development. 817
3. Describe the pertinent findings on a normal neonatal chest radiograph. 817
4. What is the correct location of umbilical arterial and venous catheters on radiographs? 817
5. What is surfactant, and why is it important? 817
6. What is the difference between RDS and a surfactant dysfunction? 817
7. How does RDS appear radiographically? 817
8. How is RDS treated, and what are the potential complications? 817
9. In addition to RDS, what are some other neonatal diffuse lung diseases? 818
10. How might other neonatal diffuse lung diseases be differentiated clinically? 818
11. What is the mechanism behind meconium aspiration, and how does it appear radiographically? 818
12. What is the mechanism behind TTN, and how does it appear radiographically? 818
13. What is neuroendocrine cell hyperplasia of infancy (NEHI), and how does it present clinically and radiographically? 818
14. What are alveolar growth disorders, and what is their CT appearance? 818
15. What are the major (prenatally diagnosed) surgical diseases of the neonatal chest? 818
16. What is the most common cause of a neonatal pleural effusion? 819
17. Describe how chlamydial pneumonia manifests clinically and radiographically. 819
18. What are the pulmonary and extrapulmonary manifestations of cystic fibrosis? 819
19. What are the findings of primary tuberculosis of the lungs in a pediatric patient? 819
20. What is acute chest syndrome? 819
21. What is lymphocytic interstitial pneumonia (LIP)? 819
22. How is a suspected aspirated foreign body evaluated? 820
23. What is Swyer-James syndrome? 820
24. What are the most common causes of metastasis to the lung in the pediatric patient? 820
25. What are some mediastinal masses one might see in the pediatric patient? 820
26. What are important structures to identify on a lateral radiograph of the pediatric neck? 820
27. What is congenital high airway obstruction syndrome (CHAOS), and why is it important to diagnose prenatally? 820
Bibliography 821
86 Pediatric Cardiovascular Radiology 822
1. What are some of the most common types of congenital heart disease (CHD) in order of frequency (most common to least common)? 822
2. How does assessment of pulmonary blood flow aid in the diagnosis of cyanotic disease? 822
3. Which types of CHD appear with cyanosis and increased pulmonary blood flow? 822
4. How is HLHS corrected surgically? 822
5. What is congenitally corrected transposition of the great vessels, and why is it a problem? 822
6. What are the most common acyanotic types of CHD? 822
7. What is the role of the radiologist in assessing suspected CHD? 822
8. What are some classic patterns of CHD seen on radiographs? 822
9. Name the major causes of CHF in a newborn. 823
10. Define the concept of situs. 823
11. What is segmental classification of CHD? 823
12. What are the most common benign pediatric cardiac/pericardial tumors? 823
13. What are the most common malignant pediatric cardiac/pericardial tumors? 823
14. What is a vascular ring? 823
15. What is the importance of a right-sided aortic arch? 823
16. What is a pulmonary artery sling? 823
17. What are MAPCAs? 824
18. What is the difference between TAPVR and scimitar syndrome? 824
19. What is meant by a malignant course of an anomalous coronary artery? 824
20. What are the two main types of coarctation of the aorta? 824
21. What is a bicuspid aortic valve (BAV)? 826
22. What are some of the major causes of pediatric pulmonary hypertension, and what are the major associated CT features? 826
23. What is Eisenmenger syndrome? 826
Bibliography 827
87 Pediatric Gastrointestinal Radiology 828
1. What are the most common causes of small bowel obstruction in a child? 828
2. What is intussusception? 828
3. What causes intussusception? 828
4. Describe the clinical signs of intussusception. 828
5. How is intussusception diagnosed with imaging? 828
6. How is an intussusception treated? 828
7. How can one tell that an intussusception has been successfully reduced? 828
8. Describe the “double bubble” sign, and name the conditions in which it is found. 829
9. What is malrotation of the intestines? 829
10. What are Ladd’s bands? 830
11. How does a midgut volvulus occur, and why is this a surgical emergency? 830
12. Does a patient with bowel malrotation always present with clinical symptoms? 830
13. What is the clinical presentation of bowel malrotation? 830
14. Which imaging study is the standard for diagnosing bowel malrotation? 830
15. List other anomalies that are associated with bowel malrotation. 831
16. Describe the clinical presentation of hypertrophic pyloric stenosis (HPS). 831
17. If the “olive” cannot be palpated, how can HPS be diagnosed with imaging studies? 831
18. What is a Meckel’s diverticulum? 831
19. How is Meckel’s diverticulum diagnosed? 832
20. What are the most common causes of GI bleeding in children? 832
21. What causes necrotizing enterocolitis (NEC)? 832
22. Who develops NEC? 832
23. What findings of NEC can be seen on radiographs, and what is the role of the radiologist? 832
24. What are other causes of pneumoperitoneum in infants and children? 832
25. What is Hirschsprung’s disease? 832
26. What are the radiographic findings of Hirschsprung’s disease? 832
27. Is Hirschsprung’s disease diagnosed definitively by imaging? 834
28. Name the types of tracheoesophageal fistulas (TEF). How common is each type? 834
29. What are the radiographic findings of TEF? 834
30. How can a radiograph help to differentiate an ingested coin in the esophagus from an aspirated coin in the trachea? 834
Bibliography 835
88 Pediatric Genitourinary Radiology 836
1. What is the role of the radiologist in pediatric urinary tract infection (UTI)? 836
2. What conditions can be detected radiologically that impair normal urinary flow? 836
3. Which imaging tests are used to diagnose these conditions? 836
4. In a child with history of UTI, what are the indications for renal and bladder US? 836
5. When is renal and bladder US performed? 836
6. How is VCUG performed? 836
7. How is VCUG modified in infants? 837
8. When should VCUG be performed? 837
9. What is voiding urosonography? 837
10. What are the pros and cons of a radionuclide cystography or voiding urosonography compared with fluoroscopic VCUG? 837
11. What is primary VUR? 837
12. What is secondary VUR? 837
13. How is primary VUR graded? 837
14. What is dysfunctional voiding? 837
15. What diagnostic tests are useful for the detection of acute and chronic pyelonephritis in children? 838
16. What are the findings on a renal cortical scintigraphic study in acute and chronic infection? 838
17. What are the CT findings associated with pyelonephritis? 838
18. What is the “top-down approach” in the evaluation of the child with a history of UTI? 838
19. How useful is renal US in the workup of suspected pyelonephritis? 838
20. What is the role of magnetic resonance imaging (MRI) in a child with UTI? 838
21. List the most common forms of congenital hydronephrosis. 838
22. When should a postnatal renal and bladder US examination be obtained in a patient with congenital hydronephrosis? 839
23. What are the roles of renal scintigraphy, VCUG, intravenous urography (IVU), and magnetic resonance urography (MRU) in congenital hydronephrosis? 839
24. What are posterior urethral valves? 839
25. How are posterior urethral valves detected? 839
26. What is primary megaureter? 839
27. What are common forms of a duplex kidney? 840
28. What is the Weigert-Meyer rule? 840
29. Are the collecting systems and ureters dilated in a duplicated system? 840
30. What is the most common cause of a scrotal mass? 840
31. What are the main differential diagnostic considerations of a painful scrotum? 840
32. If epididymitis is present in an infant, what should be suspected as the etiologic factor? 841
33. What is the most common testicular tumor in children? 842
34. What are the most common testicular tumors in adolescents? 842
35. What urinary problems occur in children with spina bifida? 842
36. Name the specific problems in spina bifida that are related to neurogenic bladder. 842
37. Discuss the goals of therapy for urinary tract dysfunction in a patient with spina bifida. 842
38. What is the triad of prune-belly syndrome? 843
39. What urinary tract abnormalities are associated with prune-belly syndrome? 843
40. What is a basic classification for cystic renal diseases affecting infants, children, and adolescents? 843
41. What is the most common US appearance of MCDK? 843
42. List the other forms of nongenetic cystic renal disease. 843
43. Name the genetic forms of cystic renal disease. 843
44. Does “adult-type” ADPCKD occur in infants and young children? 844
45. What imaging findings may help distinguish ADPCKD from ARPCKD in an infant or young child? 844
46. Name five hereditary syndromes associated with renal cysts. 844
47. What is the normal sonographic appearance of the neonatal kidney? 844
48. What conditions cause echogenic renal pyramids in infants? 844
49. List the common causes of urolithiasis in children. 845
50. What is the “twinkling” artifact? 845
51. What is the most common solid renal mass in infants? 845
52. What is the role of imaging in infants with ambiguous genitalia? 845
53. What is nephroblastomatosis? 846
54. What are the two major types of nephroblastomatosis? 846
55. How can nephroblastomatosis be distinguished from Wilms tumor? 846
56. What is Mayer-Rokitansky-Küster-Hauser syndrome? 847
57. How is pelvic US used in the evaluation of a child with precocious puberty? 847
58. What is the sonographic appearance of adrenal hemorrhage in the neonate, and how can adrenal hemorrhage be differentiated from adrenal neuroblastoma? 847
Bibliography 848
89 Pediatric Neuroradiology 849
1. How does myelinated brain differ from nonmyelinated brain on an infant magnetic resonance imaging (MRI) examination? Where does one expect to see myelinization occur first? 849
2. What are migrational anomalies of the central nervous system (CNS)? 849
3. Name the four kinds of holoprosencephalies. 850
4. What is the differential diagnosis for what appears to be massively dilated ventricles on a prenatal ultrasonography (US) or MRI examination? 850
5. Describe the classification of germinal matrix hemorrhage. 850
6. How does the premature brain respond to ischemic injury? 850
7. Describe the three main types of Chiari malformations. 850
8. How does the corpus callosum develop, and why is this important? 851
9. What entity does not follow the normal rule of corpus callosum development? 851
10. What are TORCH infections? 851
11. How do TORCH infections appear radiographically? 851
12. Discuss the CNS manifestations of neurofibromatosis type 1 (NF-1). 851
13. How is neurofibromatosis type 2 (NF-2) different from NF-1? 851
14. What is tuberous sclerosis (TS)? 851
15. Describe the manifestations of Sturge-Weber syndrome. 851
16. What are the most common brain tumors in infants? 851
17. Name the major posterior fossa tumors in children. 852
18. Describe the typical tumors that occur in the suprasellar region of a child. 852
19. Why is thickening of the pituitary stalk an important finding? 852
20. What is the differential diagnosis for a pediatric cystic neck mass? 852
21. What is the differential diagnosis for causes of leukocoria? 852
22. What is meant by trilateral retinoblastoma? 853
23. What is fibromatosis colli? Describe its imaging characteristics. 853
24. Where do cholesteatomas typically arise, and what is the role of the radiologist in their evaluation? 853
25. What is the role of the radiologist in the evaluation of sacrococcygeal teratoma? 853
Bibliography 854
90 Pediatric Musculoskeletal Radiology 855
1. How does growing bone respond to trauma, and how is this different from mature bone? 855
2. What is the significance of fractures of the physis? 855
3. How are fractures of the physis classified? 855
4. What are secondary ossification centers? 855
5. Why are secondary ossification centers particularly important to understand in the setting of elbow trauma? 855
6. What are the most common fractures of the wrist/forearm in children? 856
7. What is gymnast wrist? 856
8. What is the equivalent of gymnast wrist in the shoulder? 856
9. How may subtle supracondylar fractures of the elbow be diagnosed? 856
10. Describe nursemaid’s elbow. 856
11. List risk factors for developmental dysplasia of the hip (DDH). 856
12. When is DDH suspected clinically? 856
13. Name the potential complications of untreated DDH. 856
14. How is DDH diagnosed radiographically? 856
15. How is DDH diagnosed on ultrasonography (US)? 856
16. What is Legg-Calvé-Perthes disease? 856
17. Describe slipped capital femoral epiphysis (SCFE). 856
18. How is SCFE treated? 857
19. What are coxa vara and coxa valga? 857
20. Describe Blount disease. 857
21. What is Osgood-Schlatter disease? 857
22. What are two other common processes involving the extensor mechanism of the knee only in the pediatric patient? 857
23. What is the difference between a triplane fracture and a juvenile Tillaux fracture of the ankle? 857
24. What is Freiberg infraction? 858
25. What is a craniosynostosis? 858
26. Give the differential diagnosis for vertebra plana. 858
27. When and where do pediatric primary tumors of bone occur? 858
28. What are the most common pediatric primary tumors that metastasize to the osseous structures? 858
29. What are the benign pediatric primary bone tumors? 858
30. How should a suspected osteoid osteoma be evaluated? 858
31. If a pediatric patient presents with a palpable soft tissue mass, what are some possible underlying etiologies? 859
32. What is rickets? 859
33. How does rickets appear radiographically? 859
34. Describe the bony changes of sickle cell anemia. 859
35. What is the most common type of dwarfism, and what are its manifestations? 859
36. What is the differential diagnosis for dense metaphyseal bands, and how does one know when they are abnormally dense? 860
Bibliography 860
91 Imaging of Child Abuse 862
1. What are key history and physical examination findings that may raise suspicion of the possibility of nonaccidental trauma (NAT)? 862
2. What diagnostic algorithm might the clinician and radiologist apply if skeletal injury from child abuse is suspected? 862
3. Describe shaken infant syndrome. 862
4. What are metaphyseal corner fractures? 863
5. Name other pediatric fractures with high specificity for child abuse. 863
6. Which common fractures have low specificity for child abuse? 863
7. What features of skull fractures increase the likelihood of NAT? 863
8. What features of a fracture are useful in estimating its age? 863
9. Summarize common findings of head trauma in shaken infant syndrome. 864
10. What is the most common cause of death in a patient who has sustained NAT? 865
11. How should imaging of the brain be applied in the setting of suspected abuse? 865
12. How is the age of intracranial blood determined on MRI examinations? 865
13. Describe possible bowel findings in cases of abuse. 865
14. What is the most common cause of pediatric pancreatitis? 865
15. Describe the CT imaging features of pediatric acute pancreatitis and pancreatic lacerations. 865
16. Are multiple bruises and skeletal injuries always diagnostic of child abuse? 865
17. How does congenital syphilis mimic child abuse? 865
18. What is the differential diagnosis of periosteal reaction in a newborn? 865
19. When does physiologic periosteal new bone formation occur? 865
20. Can a metaphyseal corner fracture look like a metaphyseal lucent band? 865
21. What is the legal responsibility of any U.S. physician who suspects child abuse? 866
Bibliography 866
XIII Diagnostic Radiology as a Profession 867
92 Training Pathways in Diagnostic Imaging 869
1. Why choose radiology? 869
2. What are some common myths about radiology? 869
3. What is the usual training pathway to become a radiologist in the United States? 869
4. Do I have to match for a separate preliminary year? 869
5. Is it difficult to get a residency position in diagnostic radiology? 869
6. What can I do to help my chances of matching in radiology? 869
7. What information should my personal statement contain? 870
8. Who should write my letters of recommendation? 870
9. Are radiology positions offered outside of the National Resident Matching Program match? 870
10. To how many residency programs should I apply? 870
11. To what kind of residency programs should I apply? 870
12. What is a research track residency position? 870
13. I am an international medical graduate. What must I do to apply for a diagnostic radiology residency position in the United States? 870
14. Do I have to complete a fellowship after residency? 870
15. In what subspecialties is fellowship training offered? 870
16. What is the training pathway for nuclear medicine? 871
17. What is the training pathway for interventional radiology? 871
18. How do I become board-certified in diagnostic radiology? 871
Bibliography 871
93 Medicolegal Issues in Diagnostic Imaging 872
1. Define medical negligence. 872
2. What must be proven for a physician to be found liable for malpractice? 872
3. Outline the history of malpractice law. 872
4. List factors responsible for high medical litigation in the United States. 872
5. There can be no malpractice without established practice. Who sets the established practice, and who determines whether the established practice has been breached? 872
6. Would a general radiologist who misses a lesion on a brain magnetic resonance imaging (MRI) study be held to the standard of a neuroradiologist? 872
7. The average plaintiff award in the United States is $3.5 million. What is the aim of the award, and what are the types of damage awarded by the jury? 872
8. Can an exculpatory waiver signed by a patient shield the physician of a certain degree of liability? 873
9. A radiologist in an outpatient facility reads radiographs without ever meeting the patients. Does he or she still form a physician-patient relationship? 873
10. It is estimated that in any given year a lawsuit may be brought against 1 in 10 radiologists. What are the most common reasons radiologists get sued? 873
11. What are the groundbreaking findings of the Institute of Medicine’s report To Err is Human: Building a Safer Health System? 873
12. Radiology has unique errors. How common are perceptual errors? 873
13. What is hindsight bias, and why is it important medicolegally? 873
14. How can perceptual errors be reduced? 873
15. In 1997, the Wisconsin Court of Appeals issued a decision that has had a positive effect for radiologists sued for perceptual errors. Outline the decision. 873
16. What is the “Aunt Minnie” approach to image interpretation, and how may this approach lead to errors in judgment? 874
17. How may errors in judgment be minimized? 874
18. Explain the following terms: proximate cause, law of intervening cause, and joint and several liabilities. 874
19. Explain the following terms in the medicolegal context: vicarious liability and respondeat superior. 874
20. Who is responsible for the negligent action of a technologist? 874
21. What is meant by the term res ipsa loquitur? Give some examples. 874
22. A radiologist renders a report on an intensive care unit portable chest x-ray that reads, “Endotracheal tube in the right main bronchus should be withdrawn by 2 inches to lie within distal trachea; left lower lobe atelectasis; otherwise normal.” What additional step should the radiologist take? 874
23. A radiologist renders a report on a posteroanterior chest x-ray of a 60-year-old man with dyspnea that reads, “Opacity in the right lower lobe, likely pneumonia, clinical correlation is advised.” Is this report adequate? 875
24. A radiologist renders a report on a barium enema that reads, “Filling defect in the splenic flexure with abrupt shelf-like margins, cannot rule out malignancy; colonoscopy may be of help if clinically indicated.” What is wrong with this report? 875
25. A patient develops anaphylactic shock from iodinated contrast material for intravenous urography performed to exclude presence of renal calculi. This examination (rather than the current standard (a noncontrast abdominal computed tomography [CT] scan) was performed at the insistence of the referring urologist. Who is to blame, the radiologist or the urologist? 875
26. A radiologist reports that a lateral cervical spine radiograph is “normal except for straightening, which could be positional” in a patient who sustained acute trauma. Subsequently, the patient developed weakness in the legs, and a follow-up CT scan shows a “fracture-dislocation” at C7-T1, which is an area not covered by the original radiograph. How was the original reading substandard? 875
27. A radiologist reports an upper gastrointestinal study as follows: “Findings are highly suggestive of a scirrhous carcinoma of the stomach; endoscopy with biopsy is advised.” Biopsy results are negative. What should the radiologist do next? 875
28. Failure to diagnose breast cancer is the number one cause for litigation in radiology. Summarize how to practice safe mammography. 875
29. Only 2% of medical negligence injuries result in claims, and only 17% of claims apparently involve negligent injuries. About 60 cents of every malpractice dollar is taken by administrative and legal costs. The current tort system is inefficient. What are some reforms that have been suggested? 875
30. A 45-year-old man with uncontrollable hypertension is referred for “magnetic resonance angiography with contrast” to exclude renal artery stenosis by his cardiologist. His glomerular filtration rate is 25 mL/min/1.73 m2. He is not on dialysis. What should be your course of action? 876
31. A report states “History—suspected pulmonary embolus. … Technique—CT scan of the chest was performed.…” If all reports in this radiology practice were of similar disposition, why would this practice expect to hemorrhage money? 876
32. How does the Breast Density Law affect reporting of mammograms? 876
33. What is involved in the California Dose Reporting Regulation? 876
34. In approving screening low-dose CT scans to detect early lung cancers in smokers, the Centers for Medicaid and Medicare (CMS) oblige specific communication with the patient. What does this communication entail? 876
35. Briefly explain root cause analysis. 877
Bibliography 877
94 Radiology and Other Imaging-Related Organizations 878
1. What is the Radiological Society of North America (RSNA)? 878
2. What is the American Roentgen Ray Society (ARRS)? 878
3. What is the Association of University Radiologists (AUR)? 878
4. What is the Society of Nuclear Medicine and Molecular Imaging (SNMMI)? 878
5. What is the American Board of Radiology (ABR)? 878
6. What is the American College of Radiology (ACR)? 878
7. What is the Accreditation Council for Graduate Medical Education (ACGME)? 878
8. What are the major organizations and societies in radiology? 878
9. What are the leading academic journals in radiology? 880
10. What is the National Institute of Biomedical Imaging and Bioengineering (NIBIB)? 880
Index 881
A 881
B 883
C 885
D 888
E 889
F 890
G 891
H 892
I 894
J 895
K 895
L 895
M 896
N 899
O 899
P 900
Q 903
R 903
S 905
T 907
U 909
V 910
W 910
X 911
Y 911
Z 911
IBC-Clinical Key Ad IBC1
IFC- Expert consult pin page IFC2