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BMJ Clinical Review: Neurology and Pain

BMJ Clinical Review: Neurology and Pain

Doctor Babita Jyoti | Doctor Michael Karvelis

(2016)

Additional Information

Book Details

Abstract

A guide to imaging for common neurological problems Tourette's syndrome Restless legs syndrome Diagnosis and management of transient ischaemic attack and ischaemic stroke in the acute phase The management of spasticity in adults Post-acute care and secondary prevention after ischaemic stroke Posterior circulation ischaemic stroke First seizures in adults Drug treatment of epilepsy in adults Management of chronic epilepsy Frontotemporal dementia Chronic migraine Pharmacological prevention of migraine Cluster headache Thunderclap headache Trigeminal neuralgia Polymyalgia rheumatica Neuropathic pain: mechanisms and their clinical implications Painful diabetic neuropathy Fibromyalgia Management of chronic pain in older adults Cancer induced bone pain

Table of Contents

Section Title Page Action Price
Book Cover C
Title i
Copyright ii
About the publisher iii
About The BMJ iii
Contents iv
About the editors vi
Introduction to Neurology and Pain vii
Diagnosis and management of transient ischaemic attack and ischaemic stroke in the acute phase 1
What is an acute cerebrovascular event? 1
Is it an acute cerebrovascular event? 2
Clinical diagnosis 2
Imaging 2
Other investigations 2
How should I approach suspected TIA? 2
How will specialist services manage the patient with suspected stroke or TIA? 3
Patients with TIA 3
Patients with acute ischaemic stroke 4
Aspirin 4
Thrombolysis 4
Surgical intervention 5
Physiological monitoring and other treatments 5
Post-acute care and secondary prevention after ischaemic stroke 7
How should I assess a patient who has survived a stroke? 7
What kind of care should be delivered in hospital? 8
Evidence of benefit of stroke units 8
What makes a stroke unit? 8
Prevention of venous thrombosis 8
Feeding patients 8
Mobilisation: how soon? 9
Facilitating discharge 9
Antithrombotic following ischaemic stroke 9
How are common complications treated after stroke? 10
What measures help to prevent another stroke? 11
Management of carotid disease 11
How to manage hypertension 11
Treating high cholesterol, diabetes and lifestyle risks 12
Posterior circulation ischaemic stroke 14
What is posterior circulation ischaemic stroke? 14
What causes posterior circulation stroke? 14
What are the clinical symptoms and signs of posterior circulation ischaemia? 15
Which other disorders can mimic posterior circulation ischaemic stroke? 16
Stroke chameleons 16
Which clinical syndromes are caused by posterior circulation stroke? 16
How is posterior circulation ischaemic stroke diagnosed? 17
How is posterior circulation stroke managed? 18
Thrombolysis 18
Acute endovascular therapy 18
Neurosurgery 19
Which investigations are needed after treatment of posterior circulation stroke? 19
What treatment is recommended after posterior circulation stroke? 19
Which patients are at highest risk of deterioration or recurrence after posterior circulation minor stroke or TIA? 20
What is on the horizon for posterior circulation stroke? 21
The management of spasticity in adults 23
What is spasticity? 23
What are the clinical features of spasticity? 23
What is the differential diagnosis of spasticity? 23
How is spasticity assessed? 23
Approach to adults presenting with new onset spasticity 24
Approach to adults presenting with worsening of spasticity 24
When should a patient with spasticity be referred? 24
What is the impact of spasticity? 25
What is the aim of the management of spasticity? 25
What are the non-drug interventions for spasticity? 25
Stretching and splinting 25
Postural management and standing 26
Exercises 26
Other physical modalities 26
What are the drug interventions for spasticity? 26
Oral antispasticity drugs 26
Cannabinoids 27
Botulinum toxin 27
Intrathecal baclofen 28
Chemical neurolysis 28
First seizures in adults 30
How common are first seizures? 30
Diagnosing a first seizure: how do people present? 30
Seizures without loss of consciousness 30
Myoclonus 30
Aura (simple partial subjective seizure) 31
Simple partial motor seizure 31
Seizures with loss of consciousness 31
Absences 31
Complex partial seizure 31
Tonic-clonic seizure (convulsion) 31
Differential diagnosis of transient loss of consciousness 31
Syncope 31
Non-epileptic attack disorder 32
Should first status epilepticus and seizure clusters be considered first seizure or epilepsy? 32
Who is most at risk? 32
How should first seizure be managed? 32
Why is investigation after first seizure important? 32
What investigations are needed after first seizure in acute setting? 33
What investigations will be done at early specialist follow-up? 33
Is brain imaging needed in all first seizure patients? 33
Is this a first seizure and will it recur? 33
To treat or not to treat? 34
Does early treatment improve long term prognosis and prevent death? 34
Should we treat if provocation is ongoing? 34
What follow-up is recommended after first seizure? 34
What should we advise with regards to driving? 34
What advice should be given about safety at home and at leisure? 35
What advice should be given regarding sex following first seizure? 35
Should we warn all patients about sudden unexpected death in epilepsy? 35
Drug treatment of epilepsy in adults 37
Introduction 37
Epidemiology 37
When to start treatment 37
Selecting the first antiepileptic drug 38
Effectiveness in new onset epilepsy 38
Tolerability and safety of drugs in new onset epilepsy 41
Optimizing drug regimens 44
Drug resistant epilepsy 44
Failure of the first drug to induce sustained seizure remission and drug resistant epilepsy 45
Treatment of special patient groups 46
Women 46
Pregnant women and neonates 46
Older people 46
Patients with comorbidities 47
Patients with status epilepticus and prolonged acute convulsive seizures 48
Stopping antiepileptic drugs 48
Emerging treatments 49
Barriers to the development of new drugs for drug resistant epilepsy 49
Conclusions 49
Management of chronic epilepsy 53
Who gets epilepsy? 53
What is the goal of epilepsy treatment? 53
How is epilepsy managed? 53
What affects seizure control and prognosis in chronic epilepsy? 54
What are the factors to consider if seizure control is suboptimal? 55
Is the diagnosis correct? 55
Is the drug treatment appropriate? 55
What other medications and illnesses need to be considered? 55
Is adherence to treatment adequate? 55
Has the patient had a good trial with a maximally tolerated dose of all major antiepileptic drugs? 55
Which drug should the patient try next? 56
How can the total drug load be minimised? 56
What about epilepsy surgery? 56
How often should people with epilepsy be reviewed? 56
What should an epilepsy review include? 56
Pharmacological aspects 56
Non-pharmacological aspects 56
Chronic migraine 58
Introduction 58
Epidemiology 58
Transformation and reversion factors 59
Individual and societal effects 59
Pathophysiology 60
Diagnosis 60
History and examination 60
Differentiating chronic migraine from other primary headaches 61
Comorbid conditions 61
Treatment 61
Risk factor modification and trigger avoidance 62
Prophylaxis 62
Drug with high quality evidence (>2 randomized placebo controlled trials) 62
Drugs with lower quality evidence (1 randomized trial) 62
Drugs used for both episodic migraine and chronic migraine 63
Non-drug treatments 63
Refractory chronic migraine 63
Topics to discuss with patients 63
Active participation in treatment 63
Avoid drug overuse 63
Be patient with prophylactic treatments 63
The goal is control 63
Looking ahead 64
Research 64
Future drug treatments 64
Future non-drug treatments 64
Chronic migraine guidelines 64
Chronic migraine diagnostic criteria 64
Defining refractory chronic migraine 65
Management 65
Clinical trial design for studies of chronic migraine 65
Conclusions 65
Pharmacological prevention of migraine 68
When to consider prevention for migraine 68
What are the goals of preventive treatment? 68
What do the treatments prevent? 68
What drugs are available for the prevention of migraine? 68
β blockers 68
Calcium channel blockers 69
Other antihypertensive drugs 69
Antidepressants 69
Antiepileptic drugs 69
Supplements and herbs 70
Other drugs 70
Botulinum toxin A 70
Combination treatment 70
When should preventive treatment be discontinued? 70
Cluster headache 72
What is cluster headache? 72
Who gets it? 72
How is cluster headache diagnosed? 72
Where is the pain and what is it like? 73
How long does an attack last? 73
How often do individual attacks occur? 74
Which other symptoms occur with the attack? 74
Does anything trigger the attacks? 74
How often do bouts of attacks occur? 74
Which conditions resemble cluster headache? 75
How should patients with cluster headache be managed? 75
Treatment of individual attacks 75
Oxygen 75
Triptans 75
Preventive treatment 75
Nerve blocks and infusions 76
Neuromodulation 76
Thunderclap headache 78
What is a thunderclap headache? 78
How should a patient with thunderclap headache be assessed? 78
What are the most common causes? 78
Subarachnoid haemorrhage 78
Reversible cerebral vasoconstriction syndrome 79
What are the less common causes of thunderclap headache? 80
Causes detected by plain CT or lumbar puncture 80
Causes that can be missed by plain CT and lumbar puncture 81
Which investigations are needed? 81
When is four vessel cerebral angiography still necessary? 82
What about primary headache disorders as a cause of thunderclap headache? 82
Restless legs syndrome 83
What is it? 83
Who gets it? 83
What causes restless legs syndrome? 84
What else could it be? 84
What impact does restless legs syndrome have on health? 84
How is restless legs syndrome managed? 85
What problems are associated with dopamine agonists? 85
How do I choose between different dopamine agonists? 85
What other drugs are available? 86
Whom should I refer to a specialist? 86
Neuropathic pain: mechanisms and their clinical implications 88
Introduction 88
Rationale for mechanism based treatment 88
Search methods 88
Physiology and classification 89
Emotional versus physiological aspects 90
Peripheral mechanisms 92
Peripheral sensitization 92
Expression of ion channels 92
Phenotypic switch 92
Sensory denervation and sprouting of collateral nerve fibers 92
Sympathetically maintained pain 93
Spinal mechanisms 94
Spinal glutamatergic regulation 94
Glial activation and proinflammatory cytokines 94
Supraspinal mechanisms 95
Disinhibition 96
Spinal cord level 96
Supraspinal level 96
Neuropathic versus nociceptive pain: different entities or part of the same continuum? 96
Emerging treatments 97
Conclusions 97
Management of lumbar spinal stenosis 100
Introduction 100
Incidence and prevalence 100
Sources and selection criteria 100
Definition 100
Causes 101
Symptoms and signs 101
Natural course of LSS 102
Pathophysiology 102
Diagnosis 102
Electrodiagnostics 103
Imaging 103
Clinical prediction rules 103
Management 104
Non-surgical options 104
Drugs 104
Physiotherapy 104
Injections 105
Other non-surgical options 105
Surgical options 105
Decompression 105
Role of postoperative rehabilitation 106
Role of fusion 106
Interspinous spacers 107
The MILD procedure 107
Associated conditions affecting treatment 107
Degenerative spondylolisthesis 107
Degenerative scoliosis 108
Conclusion 108
Opioids for low back pain 112
Introduction 112
Sources and selection criteria 112
Incidence and prevalence of low back pain 112
Prevalence of symptoms 112
Prevalence of pathophysiologic changes 113
Trends in opioid prescribing 113
Efficacy and effectiveness of opioids for low back pain 113
Acute low back pain 113
Chronic low back pain 114
Opioids versus placebo 114
Opioids versus other drugs 114
Observational studies for chronic back pain 115
Reasons for potential loss of efficacy 115
Responses to opioid tapering 115
Adverse effects of opioid treatment for low back pain 116
Opioid dependency, misuse, and addiction 116
Dependency 116
Problem use of prescription opioids 116
Prevalence of problem use 117
Overdose and mortality risks 117
Other adverse effects 118
Sedation and dizziness 118
Depression 118
Endocrine effects 118
Interference with other treatments 118
Reducing risks of opioid therapy 118
Screening 118
Newer safety strategies 119
Prescription drug monitoring programs 119
Reformulation 120
Emerging treatments 120
Guidelines 120
Conclusion 120
Trigeminal neuralgia 124
How common is trigeminal neuralgia? 124
Who are most at risk of having trigeminal neuralgia? 124
What is the underlying pathophysiology of trigeminal neuralgia? 124
How is trigeminal neuralgia diagnosed? 124
What investigations should be done? 125
Imaging 125
Biochemical investigations 126
What are the medical options for treatment? 126
What are the surgical options? 127
What to do in a crisis? 128
What other support is available for patients with trigeminal neuralgia? 129
Painful diabetic neuropathy 131
Introduction 131
Epidemiology 131
Classification 131
Diagnostic studies 132
Important patient outcomes 133
Treatment 134
Prevention 134
Symptoms 134
Antiepileptic drugs 134
Antidepressants with effects on norepinephrine reuptake 134
Opioid based drugs 134
α lipoic acid 135
Topical treatments 135
Non-pharmacologic treatments 135
Summary of evidence on treatment 135
Guidelines and recommendations 135
What to discuss with patients 136
Challenging assumptions in diabetic neuropathy 136
Unresolved questions and emerging treatments 136
Conclusions 137
Fibromyalgia 140
What is fibromyalgia and how common is it? 140
Who gets fibromyalgia? 140
What causes fibromyalgia? 141
Why and how should fibromyalgia be diagnosed? 141
Treatment of fibromyalgia 142
What is the role of non-drug treatments? 142
Physical therapies (active) 143
Physical therapies (passive) 143
Acupuncture 143
Psychological therapies 143
How effective are drugs in the treatment of fibromyalgia? 144
Analgesics 144
Opioids 144
Antidepressant drugs 144
Anticonvulsant drugs 145
Other drugs 146
How strong is the evidence from clinical trials in fibromyalgia? 146
Complex regional pain syndrome 148
Introduction 148
Incidence 148
Incidence in the general population 148
Incidence after injury 149
Sources and selection criteria 149
Pathophysiology 149
Factors related to the initiating injury 149
Central and peripheral nociceptive sensitization 150
Altered sympathetic nervous system function and sympatho-afferent coupling 151
Inflammatory and immune related factors 151
Brain changes 151
Genetic factors 152
Psychological factors 152
Natural course of CRPS 152
Acute CRPS 152
Chronic CRPS 153
Delayed healing versus emerging CRPS 153
Warm and cold CRPS 153
Traditional CPRS stages 153
CPRS spread 153
Diagnosis 154
Treatment 154
Drug treatment 155
Ganglion blocks 155
Spinal cord stimulation 156
Psychological interventions 156
Can CRPS be prevented? 156
Vitamin C 156
Ischemic reperfusion injury 156
CRPS in children 156
Emerging treatments 156
Guidelines 156
Conclusion 157
Polymyalgia rheumatica 161
What is polymyalgia rheumatica? 161
What are the objective abnormalities in polymyalgia rheumatica? 161
Can polymyalgia rheumatica “overlap” with other rheumatological disorders? 161
Association with giant cell arteritis 161
Overlap with rheumatoid arthritis 162
Genetic heterogeneity 162
How is polymyalgia rheumatica diagnosed? 162
How can the classic clinical features of polymyalgia rheumatica be identified? 162
What further investigations are recommended before starting glucocorticoids? 163
When should glucocorticoids be started? 163
When and how should the glucocorticoid dose be tapered? 164
What if patients cannot tolerate glucocorticoid withdrawal even years later? 164
What are the risks of long term glucocorticoids and how can they be reduced? 165
What is the prognosis in polymyalgia rheumatica? 165
Temporomandibular disorders 168
What are TMDs? 168
How common are TMDs and who gets them? 168
What causes TMDs? 168
What are the clinical features? 169
How are TMDs diagnosed? 169
Axis 1 169
Axis 2 170
What are the red flags? 170
What makes TMDs more likely to become a chronic musculoskeletal pain? 170
What is the management? 170
Reversible and conservative treatments 170
Irreversible approaches 172
Why is psychological management of TMDs important? 172
Management of chronic pain in older adults 176
What is chronic pain and how is it caused? 176
Who gets it? 176
How are older patients with chronic pain assessed? 176
History 177
Examination 177
Imaging 177
Assessing pain in older patients with major cognitive impairment 177
What is the approach to management? 178
Social aspects of management 179
Home visits 179
What drug interventions are available? 180
Paracetamol 180
Non-steroidal anti-inflammatory drugs 180
Opioids 180
What psychological interventions are available? 181
Cognitive behavioral therapy 181
Self management programs 181
What rehabilitative and exercise approaches are available? 181
When should patients be referred to a pain specialist? 182
What is the role of mobile health technology? 182
What limitations exist in the evidence base about treatment? 182
Cancer induced bone pain 184
What is cancer induced bone pain? 184
Who gets cancer induced bone pain? 184
What are the clinical features of cancer induced bone pain? 184
How is cancer induced bone pain initially managed? 185
Non-drug interventions 185
World Health Organization pain ladder 185
Strong opioids 186
Other drug interventions 186
What further treatment options are available? 187
Radiotherapy 187
Radioisotopes 187
Bisphosphonates 187
Denosumab 187
Interventional procedures 187
Surgery 187
Complementary therapies 188
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