BOOK
Gynecologic Pathology, An Issue of Surgical Pathology Clinics, E-Book
Blaise Clarke | Glenn McCluggage
(2016)
Additional Information
Book Details
Abstract
This issue of the Surgical Pathology Clinics, edited by Drs. Blaise Clarke and Glenn McCluggage, focuses on Gynecologic Pathology. Topics covered in the issue include, but are not limited to: Gynecologic manifestations of the DICER1 syndrome; Prophylactic gynecologic specimens from hereditary cancer carriers; Lynch syndrome associated endometrial cancer; Peutz-jeghers syndrome associated gynecologic tumors; Gynecologic manifestations of less commonly encountered hereditary syndromes; and Clinical testing for hereditary predisposition.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Gynecologic Pathology | i | ||
| Copyright | ii | ||
| Contributors | iii | ||
| CONSULTING EDITOR | iii | ||
| EDITORS | iii | ||
| AUTHORS | iii | ||
| Contents | v | ||
| Preface: Gynecologic Pathology | v | ||
| Ovarian Cancer in Hereditary Cancer Susceptibility Syndromes | v | ||
| Lynch Syndrome: Female Genital Tract Cancer Diagnosis and Screening | v | ||
| Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary): A Review with Recent Devel ... | v | ||
| Gynecologic Manifestations of the DICER1 Syndrome | v | ||
| Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathol ... | vi | ||
| Gynecologic Manifestations of Less Commonly Encountered Hereditary Syndromes | vi | ||
| Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma | vi | ||
| Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis? | vi | ||
| Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers | vii | ||
| Special Article | vii | ||
| Image Analysis in Surgical Pathology | vii | ||
| SURGICAL PATHOLOGY CLINICS | viii | ||
| FORTHCOMING ISSUES | viii | ||
| September 2016 | viii | ||
| December 2016 | viii | ||
| March 2017 | viii | ||
| RECENT ISSUES | viii | ||
| March 2016 | viii | ||
| December 2015 | viii | ||
| September 2015 | viii | ||
| Preface:\rGynecologic Pathology | ix | ||
| Ovarian Cancer in Hereditary Cancer Susceptibility Syndromes | 189 | ||
| ABSTRACT | 189 | ||
| OVERVIEW | 189 | ||
| OVARIAN CARCINOMA | 190 | ||
| HIGH-GRADE SEROUS CARCINOMA | 190 | ||
| LOW-GRADE SEROUS CARCINOMA | 191 | ||
| CLEAR CELL CARCINOMA | 191 | ||
| ENDOMETRIOID CARCINOMA | 192 | ||
| MUCINOUS CARCINOMA | 192 | ||
| OVARIAN CARCINOMA: HISTOTYPE DIFFERENTIAL DIAGNOSIS | 192 | ||
| HEREDITARY BREAST AND OVARIAN CANCER SYNDROME | 193 | ||
| LYNCH SYNDROME (HEREDITARY NONPOLYPOSIS COLORECTAL CANCER SYNDROME) | 194 | ||
| SUMMARY | 196 | ||
| REFERENCES | 196 | ||
| Lynch Syndrome | 201 | ||
| ABSTRACT | 201 | ||
| OVERVIEW | 201 | ||
| FUNCTION OF DNA MISMATCH REPAIR GENES | 202 | ||
| LYNCH SYNDROME FEMALE GENITAL TRACT TUMORS | 202 | ||
| LYNCH SYNDROME FEMALE GENITAL TRACT CANCER RISK DIFFERS BY MUTATIONAL STATUS | 204 | ||
| SCREENING FOR LYNCH SYNDROME | 204 | ||
| TESTING FOR LYNCH SYNDROME | 205 | ||
| GERMLINE MUTATIONAL ANALYSIS | 205 | ||
| IMMUNOHISTOCHEMISTRY FOR DNA MISMATCH REPAIR PROTEINS | 205 | ||
| MICROSATELLITE INSTABILITY ANALYSIS | 206 | ||
| MLH1 PROMOTER METHYLATION ASSAY | 207 | ||
| DNA MISMATCH REPAIR GENE MUTATION ANALYSIS | 208 | ||
| SOMATIC MUTATIONAL ANALYSIS | 209 | ||
| PROGNOSTIC AND THERAPEUTIC IMPLICATIONS OF MISMATCH REPAIR ABNORMALITIES IN ENDOMETRIAL AND OVARIAN CARCINOMA | 209 | ||
| SURVEILLANCE AND RISK-REDUCING STRATEGIES FOR ENDOMETRIAL AND OVARIAN CARCINOMAS IN LYNCH SYNDROME | 211 | ||
| SUMMARY | 211 | ||
| REFERENCES | 211 | ||
| Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary) | 215 | ||
| ABSTRACT | 215 | ||
| OVERVIEW AND HISTORY OF THE DISEASE | 216 | ||
| CLINICAL PRESENTATION AND OUTCOME | 216 | ||
| PATHOLOGY OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 217 | ||
| GENETICS AND HISTOGENESIS OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 217 | ||
| USING IMMUNOHISTOCHEMISTRY TO DIAGNOSE SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 219 | ||
| MANAGEMENT OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 220 | ||
| CURRENT AND FUTURE RESEARCH | 220 | ||
| DIAGNOSTIC/GENETIC TESTING ALGORITHM FOR SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 221 | ||
| DIFFERENTIAL DIAGNOSIS OF SMALL-CELL CARCINOMA OF THE OVARY OF HYPERCALCEMIC TYPE | 221 | ||
| SEX CORD–STROMAL TUMORS | 222 | ||
| OVARIAN SMALL-CELL CARCINOMA OF PULMONARY TYPE (SMALL-CELL NEUROENDOCRINE CARCINOMA) | 222 | ||
| DESMOPLASTIC SMALL ROUND CELL TUMOR | 223 | ||
| EWING FAMILY OF TUMORS | 223 | ||
| MISCELLANEOUS NEOPLASMS | 224 | ||
| REFERENCES | 224 | ||
| Gynecologic Manifestations of the DICER1 Syndrome | 227 | ||
| ABSTRACT | 227 | ||
| MOLECULAR OVERVIEW OF DICER1 | 227 | ||
| OVARIAN SEX CORD–STROMAL TUMORS | 229 | ||
| BACKGROUND AND CLINICAL FEATURES | 229 | ||
| HISTOLOGIC FEATURES | 230 | ||
| DIFFERENTIAL DIAGNOSIS | 233 | ||
| PROGNOSIS | 236 | ||
| CERVICAL EMBRYONAL RHABDOMYOSARCOMA | 236 | ||
| BACKGROUND AND CLINICAL FEATURES | 236 | ||
| HISTOLOGIC FEATURES | 236 | ||
| DIFFERENTIAL DIAGNOSIS | 237 | ||
| PROGNOSIS | 239 | ||
| OTHER OVARIAN NEOPLASMS POSSIBLY LINKED TO DICER1 SYNDROME | 239 | ||
| ACKNOWLEDGMENTS | 239 | ||
| REFERENCES | 239 | ||
| Peutz-Jeghers Syndrome | 243 | ||
| ABSTRACT | 243 | ||
| OVERVIEW | 243 | ||
| INTRODUCTION | 244 | ||
| HISTORY OF THE DISEASE | 244 | ||
| CLINICAL FEATURES | 244 | ||
| PATHOBIOLOGICAL UNDERPINNINGS | 245 | ||
| GYNECOLOGIC TUMORS IN PEUTZ-JEGHERS SYNDROME | 246 | ||
| SEX CORD TUMOR WITH ANNULAR TUBULES | 246 | ||
| Brief Introduction | 246 | ||
| Gross Features | 246 | ||
| Microscopic Features | 247 | ||
| Differential Diagnosis | 248 | ||
| Diagnosis | 248 | ||
| Prognosis | 250 | ||
| OVARIAN SERTOLI CELL TUMOR | 251 | ||
| Brief Introduction | 251 | ||
| Gross Features | 251 | ||
| Microscopic Features | 251 | ||
| Differential Diagnosis | 251 | ||
| Diagnosis | 254 | ||
| Prognosis | 254 | ||
| GASTRIC-TYPE ENDOCERVICAL ADENOCARCINOMA | 255 | ||
| Brief Introduction | 255 | ||
| Gross Features | 255 | ||
| Microscopic Features | 255 | ||
| Differential Diagnosis | 255 | ||
| Diagnosis | 255 | ||
| Prognosis | 257 | ||
| EXTREMELY WELL-DIFFERENTIATED GASTRIC-TYPE ADENOCARCINOMA AND LOBULAR ENDOCERVICAL GLANDULAR HYPERPLASIA | 258 | ||
| Brief Introduction | 258 | ||
| Gross Features | 258 | ||
| Microscopic Features | 258 | ||
| Differential Diagnosis | 259 | ||
| Diagnosis | 261 | ||
| Prognosis | 261 | ||
| RECOMMENDATIONS FOR SCREENING, MANAGEMENT, AND ADDITIONAL GENETIC TESTING | 263 | ||
| REFERENCES | 265 | ||
| Gynecologic Manifestations of Less Commonly Encountered Hereditary Syndromes | 269 | ||
| ABSTRACT | 269 | ||
| HEREDITARY LEIOMYOMATOSIS RENAL CELL CARCINOMA SYNDROME | 269 | ||
| CLINICAL FEATURES | 269 | ||
| GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS | 269 | ||
| DIFFERENTIAL DIAGNOSIS | 271 | ||
| PROGNOSIS | 271 | ||
| TUBEROUS SCLEROSIS COMPLEX | 271 | ||
| LYMPHANGIOLEIOMYOMATOSIS | 272 | ||
| PERIVASCULAR EPITHELIOID CELL TUMOR | 272 | ||
| DIFFERENTIAL DIAGNOSIS | 274 | ||
| PROGNOSIS | 275 | ||
| COWDEN SYNDROME | 275 | ||
| CLINICAL FEATURES | 276 | ||
| PTEN AND ENDOMETRIAL CANCER | 276 | ||
| PROGNOSIS | 276 | ||
| NEVOID BASAL CELL CARCINOMA SYNDROME | 277 | ||
| CLINICAL FEATURES | 278 | ||
| GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS | 278 | ||
| DIFFERENTIAL DIAGNOSIS | 278 | ||
| PROGNOSIS | 280 | ||
| VON HIPPEL-LINDAU SYNDROME | 280 | ||
| CLINICAL FEATURES | 280 | ||
| GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS | 280 | ||
| DIFFERENTIAL DIAGNOSIS | 280 | ||
| PROGNOSIS | 281 | ||
| MAFFUCCI SYNDROME AND OLLIER DISEASE | 281 | ||
| CLINICAL FEATURES | 282 | ||
| GROSS/MICROSCOPIC FEATURES AND DIAGNOSIS | 282 | ||
| DIFFERENTIAL DIAGNOSIS | 282 | ||
| PROGNOSIS | 283 | ||
| CARNEY COMPLEX | 283 | ||
| OVARIAN LESIONS IN CARNEY COMPLEX | 283 | ||
| DIFFERENTIAL DIAGNOSIS | 283 | ||
| PROGNOSIS | 284 | ||
| REFERENCES | 284 | ||
| Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma | 289 | ||
| ABSTRACT | 289 | ||
| LYNCH SYNDROME | 289 | ||
| TUMOR TESTING AND PITFALLS IN TEST INTERPRETATION | 290 | ||
| Immunohistochemistry | 290 | ||
| Microsatellite Instability and MLH1 Methylation Analyses | 291 | ||
| DISCREPANCIES BETWEEN TISSUE TESTING AND GENETIC TESTING | 292 | ||
| Known Mismatch Repair Gene Mutations and Ambiguous or Normal Tissue Testing Results | 292 | ||
| Abnormal Tissue Testing Results and No Detectable Mismatch Repair Gene Mutations | 293 | ||
| STRATEGIES AND CHALLENGES OF SCREENING FOR LYNCH SYNDROME IN ENDOMETRIAL CARCINOMA | 295 | ||
| PATHOLOGIC FEATURES OF LYNCH SYNDROME–ASSOCIATED ENDOMETRIAL CANCER | 296 | ||
| REFERENCES | 297 | ||
| Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis? | 301 | ||
| ABSTRACT | 301 | ||
| OVERVIEW | 301 | ||
| GENETIC TESTING | 302 | ||
| HISTORIC METHODS | 302 | ||
| CURRENT TESTING METHODS | 302 | ||
| WHEN IS A GENE READY FOR ROUTINE CANCER PREDISPOSITION TESTING? | 303 | ||
| SINGLE-GENE VERSUS GENE PANEL VERSUS WHOLE-EXOME VERSUS WHOLE-GENOME APPROACHES TO CLINICAL GENETIC TESTING | 303 | ||
| SOMATIC GENETIC TESTING OR GERMLINE GENETIC TESTING? | 304 | ||
| OPTIMIZING ACCESS TO GENETIC TESTING FOR HEREDITARY PREDISPOSITION TO GYNECOLOGIC CANCERS | 305 | ||
| REFERENCES | 305 | ||
| Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers | 307 | ||
| ABSTRACT | 307 | ||
| OVERVIEW | 307 | ||
| MUTATIONS OF BRCA1 AND BRCA2 AND PREVENTION OF HIGH-GRADE SEROUS CARCINOMA | 309 | ||
| PROCESSING OF RISK-REDUCING SALPINGO-OOPHORECTOMY SPECIMENS | 309 | ||
| GROSS FEATURES | 310 | ||
| OCCULT HIGH-GRADE SEROUS CARCINOMA | 310 | ||
| MICROSCOPIC | 311 | ||
| SEROUS TUBAL INTRAEPITHELIAL CARCINOMA | 312 | ||
| MICROSCOPIC | 313 | ||
| SEROUS TUBAL INTRAEPITHELIAL LESION | 318 | ||
| Image Analysis in Surgical Pathology | 329 | ||
| ABSTRACT | 329 | ||
| OVERVIEW | 329 | ||
| PROCESSES | 330 | ||
| IMAGE SEGMENTATION | 330 | ||
| Splitting | 331 | ||
| Thresholding, Watershedding, and/or Histogram-Based Techniques | 332 | ||
| Clustering | 332 | ||
| Edge Detection | 332 | ||
| Partial-Differential Equations | 332 | ||
| Graph Partitioning | 332 | ||
| Trainable Techniques | 332 | ||
| STATISTICAL CLASSIFICATION | 332 | ||
| Markov Chains and Markov Meshes | 333 | ||
| Naive Bayes Classifiers | 333 | ||
| Support Vector Machines | 333 | ||
| Regression | 333 | ||
| Random Forest Classifiers | 334 | ||
| FEATURE EXTRACTION, RESULT GENERATION, INTERPRETATION, AND REPORTING | 334 | ||
| IMAGE ANALYSIS FOR BASIC AND TRANSLATIONAL RESEARCH USE | 334 | ||
| IMAGE ANALYSIS FOR CLINICAL USE | 335 | ||
| SUMMARY | 335 | ||
| REFERENCES | 335 |