BOOK
Novel Approaches to the Management of Sleep-Disordered Breathing, An Issue of Sleep Medicine Clinics, E-Book
(2016)
Additional Information
Book Details
Abstract
This issue of Sleep Medicine Clinics focuses on Novel Therapies for Sleep-Disorderd Breathing. Article topics include: The problems and pitfalls with current approaches to managing sleep disordered breathing; New approaches to diagnosing sleep disordered breathing; Monitoring progress and adherence with PAP therapy for OSA; The future of dental approaches for the treatment of OSA; Pharmacologic approaches for the treatment of OSA; Novel therapies for the treatment of central sleep apnea; Advances and new approaches to managing sleep disordered breathing related to chronic pulmonary disease; The role of big data in the management of sleep disordered breathing; Using genes and biomarkers to assess risk and identify optimal treatments for patients with sleep disordered breathing, and more!
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Novel Approaches tothe Management ofSleep-Disordered Breathing | i | ||
| Copyright\r | ii | ||
| CME Accreditation Page | iii | ||
| PROGRAM OBJECTIVE | iii | ||
| TARGET AUDIENCE | iii | ||
| LEARNING OBJECTIVES | iii | ||
| ACCREDITATION | iii | ||
| DISCLOSURE OF CONFLICTS OF INTEREST | iii | ||
| UNAPPROVED/OFF-LABEL USE DISCLOSURE | iii | ||
| TO ENROLL | iv | ||
| METHOD OF PARTICIPATION | iv | ||
| CME INQUIRIES/SPECIAL NEEDS | iv | ||
| SLEEP MEDICINE CLINICS\r | v | ||
| FORTHCOMING ISSUES | v | ||
| September 2016 | v | ||
| December 2016 | v | ||
| March 2017 | v | ||
| RECENT ISSUES | v | ||
| March 2016 | v | ||
| December 2015 | v | ||
| September 2015 | v | ||
| Contributors | vii | ||
| CONSULTING EDITOR | vii | ||
| EDITOR | vii | ||
| AUTHORS | vii | ||
| Contents | ix | ||
| Preface: Novel Approaches to the Management of Sleep-Disordered Breathing: Reviewing the Past and Looking Into the Future\r | ix | ||
| New Approaches to Diagnosing Sleep-Disordered Breathing\r | ix | ||
| New Approaches to Positive Airway Pressure Treatment in Obstructive Sleep Apnea\r | ix | ||
| Monitoring Progress and Adherence with Positive Airway Pressure Therapy for Obstructive Sleep Apnea: The Roles of Telemedic\r | ix | ||
| Novel Approaches to the Management of Sleep-Disordered Breathing\r | ix | ||
| Novel Surgical Approaches for the Treatment of Obstructive Sleep Apnea\r | x | ||
| Pharmacologic Approaches to the Treatment of Obstructive Sleep Apnea\r | x | ||
| The Challenges of Precision Medicine in Obstructive Sleep Apnea\r | x | ||
| Novel Therapies for the Treatment of Central Sleep Apnea\r | x | ||
| The Role of Big Data in the Management of Sleep-Disordered Breathing\r | xi | ||
| Advances and New Approaches to Managing Sleep-Disordered Breathing Related to Chronic Pulmonary Disease\x0B | xi | ||
| Preface\rNovel Approaches to the Management of Sleep-Disordered Breathing: Reviewing the Past and Looking Into the Future | xiii | ||
| New Approaches to Diagnosing Sleep-Disordered Breathing | 143 | ||
| Key points | 143 | ||
| DETECTING THE PRESENCE OF EVENTS: DIAGNOSTIC AND SCREENING TECHNOLOGY | 143 | ||
| Home Sleep Testing | 144 | ||
| Novel Approaches to Screening and Monitoring Sleep Apnea | 144 | ||
| Snoring and breathing sounds | 145 | ||
| Electrocardiogram | 145 | ||
| Motion detection | 145 | ||
| AUTOMATED AND COMPUTER-ASSISTED SCORING TECHNOLOGY | 146 | ||
| Sleep State and Arousals | 146 | ||
| Respiratory Events | 146 | ||
| APPROACHES TO DIAGNOSING SLEEP APNEA PATHOPHYSIOLOGY FOR GUIDING TREATMENT DECISIONS | 147 | ||
| Upper Airway Collapsibility: Severity | 147 | ||
| Upper Airway Muscle Compensation | 148 | ||
| Upper Airway Collapsibility: Site | 148 | ||
| High Loop Gain | 148 | ||
| Arousal Threshold, Sleep State Instability | 149 | ||
| SUMMARY | 149 | ||
| REFERENCES | 149 | ||
| New Approaches to Positive Airway Pressure Treatment in Obstructive Sleep Apnea | 153 | ||
| Key points | 153 | ||
| INTRODUCTION | 153 | ||
| CONTINUOUS POSITIVE AIRWAY PRESSURE UNITS | 153 | ||
| MODES OF CONTINUOUS POSITIVE AIRWAY PRESSURE DELIVERY | 153 | ||
| AUTOTITRATING POSITIVE AIRWAY PRESSURE | 154 | ||
| AUTOTRIAL MODE AND AUTOMATIC PRESSURE ADJUSTMENT (CONTINUOUS POSITIVE AIRWAY PRESSURE CHECK) | 154 | ||
| EXPIRATORY RELIEF | 154 | ||
| MASK INTERFACES | 155 | ||
| HEATED HUMIDIFICATION | 155 | ||
| HEATED TUBING | 155 | ||
| COMPLIANCE MONITORING | 156 | ||
| COMPLIANCE MONITORING BY THE PATIENT | 156 | ||
| FUTURE DIRECTIONS OF POSITIVE AIRWAY PRESSURE TREATMENT IN OBSTRUCTIVE SLEEP APNEA | 157 | ||
| REFERENCES | 157 | ||
| Monitoring Progress and Adherence with Positive Airway Pressure Therapy for Obstructive Sleep Apnea | 161 | ||
| Key points | 161 | ||
| INTRODUCTION | 161 | ||
| OVERVIEW OF TELEMEDICINE | 162 | ||
| Definitions | 162 | ||
| Asynchronous Telemedicine | 162 | ||
| Overview | 162 | ||
| Electronic messaging | 162 | ||
| Remote monitoring | 163 | ||
| Automated and self-management mechanisms | 163 | ||
| SLEEP MEDICINE AND TELEMEDICINE | 163 | ||
| Overview | 163 | ||
| Telemedicine and Obstructive Sleep Apnea Education | 164 | ||
| Telemedicine and Continuous Positive Airway Pressure Follow-up | 164 | ||
| Overview | 164 | ||
| Wireless transfer of continuous positive airway pressure data | 165 | ||
| Automated mechanisms and self-management continuous positive airway pressure follow-up platforms | 165 | ||
| Current Sleep Telemedicine Solutions | 166 | ||
| HEALTH INFORMATION TECHNOLOGY: THE DEVELOPING ECOSYSTEM | 167 | ||
| Overview | 167 | ||
| Sleep Mobile Device Applications and Wearable Sensors | 167 | ||
| Background | 167 | ||
| Types of devices | 167 | ||
| Activity trackers | 168 | ||
| Practical implications | 168 | ||
| Peer-Based Follow-up | 168 | ||
| Electronic Health Records and Technology Integration | 168 | ||
| General concepts | 168 | ||
| Device integration | 169 | ||
| Data analytics: population health management | 169 | ||
| Work flow integration: clinical care pathways | 169 | ||
| SUMMARY | 170 | ||
| REFERENCES | 170 | ||
| Novel Approaches to the Management of Sleep-Disordered Breathing | 173 | ||
| Key points | 173 | ||
| INTRODUCTION | 173 | ||
| Surgical Treatment Options for Obstructive Sleep Apnea | 174 | ||
| Bariatric surgery | 174 | ||
| Uvulopalatopharyngoplasty | 174 | ||
| Oral Appliances | 174 | ||
| Tongue-retaining device | 175 | ||
| Mandibular repositioning devices | 176 | ||
| Design selection of mandibular repositioning devices | 177 | ||
| Oral Appliance Calibration Technology | 178 | ||
| Multiple sleep testing titration | 178 | ||
| Predictive jaw positioning: real-time sleep testing | 178 | ||
| Predicting starting jaw position: measurement-based | 178 | ||
| Oral Appliance Adherence Monitoring Technology | 180 | ||
| Noncustom Oral Appliances | 180 | ||
| Positional Therapy | 180 | ||
| Expiratory Positive Airway Pressure | 181 | ||
| Pharmacologic Treatment of Obstructive Sleep Apnea | 182 | ||
| Predictive Models for Selecting Alternative Therapies | 182 | ||
| Phenotyping models: oral appliance therapy | 183 | ||
| The role of pharyngeal muscle response | 183 | ||
| Oral Myofunctional Therapy | 183 | ||
| Orthodontics | 184 | ||
| Combination Therapy | 184 | ||
| SUMMARY | 185 | ||
| SUPPLEMENTARY DATA | 186 | ||
| REFERENCES | 186 | ||
| Novel Surgical Approaches for the Treatment of Obstructive Sleep Apnea | 189 | ||
| Key points | 189 | ||
| INTRODUCTION: THE ROLE OF SURGICAL THERAPY | 189 | ||
| Novel Diagnostic Evaluation Approach | 190 | ||
| Drug-induced sedation endoscopy | 190 | ||
| Background | 190 | ||
| Technique | 190 | ||
| Phenotyping the upper airway | 191 | ||
| Indications | 192 | ||
| Future | 192 | ||
| Novel Airway Surgery Approach | 193 | ||
| Expansion sphincter pharyngoplasty | 193 | ||
| Background | 193 | ||
| Need for procedure modifications | 193 | ||
| Improving effectiveness | 193 | ||
| Reducing morbidity | 193 | ||
| Indications | 194 | ||
| Surgical technique | 194 | ||
| Outcomes data | 194 | ||
| Future | 194 | ||
| Novel Therapeutic Approach | 194 | ||
| Hypoglossal nerve stimulation therapy | 194 | ||
| Background | 194 | ||
| Electrical stimulation of the upper airway | 195 | ||
| Human pilot and feasibility studies | 196 | ||
| Anatomic effect on the upper airway | 196 | ||
| Surgical technique | 197 | ||
| Follow-up | 198 | ||
| Indications | 198 | ||
| Data from the stimulation therapy for apnea reduction trial | 199 | ||
| Discussion | 199 | ||
| Comparison of upper airway stimulation to other obstructive sleep apnea treatments | 199 | ||
| Future directions | 200 | ||
| SUMMARY | 200 | ||
| REFERENCES | 200 | ||
| Pharmacologic Approaches to the Treatment of Obstructive Sleep Apnea | 203 | ||
| Key points | 203 | ||
| INTRODUCTION | 203 | ||
| Upper Airway Anatomy or Collapsibility | 203 | ||
| The Challenges of Precision Medicine in Obstructive Sleep Apnea | 213 | ||
| Key points | 213 | ||
| SLEEP-DISORDERED BREATHING AND OBSTRUCTIVE SLEEP APNEA | 213 | ||
| PEDIATRIC OBSTRUCTIVE SLEEP APNEA | 214 | ||
| ADULT OBSTRUCTIVE SLEEP APNEA | 214 | ||
| TREATMENT OF OBSTRUCTIVE SLEEP APNEA | 214 | ||
| THE LONG AND COMPLEX ROAD TO BIOMARKER DISCOVERY AND IMPLEMENTATION | 215 | ||
| TRANSCRIPTOMICS | 216 | ||
| CIRCULATING MICRORNA | 218 | ||
| SINGLE-NUCLEOTIDE POLYMORPHISMS | 219 | ||
| EPIGENOMICS | 220 | ||
| PROTEOMICS | 221 | ||
| SUMMARY AND FUTURE DIRECTIONS | 221 | ||
| REFERENCES | 221 | ||
| Novel Therapies for the Treatment of Central Sleep Apnea | 227 | ||
| Key points | 227 | ||
| INTRODUCTION | 227 | ||
| CENTRAL SLEEP APNEA AND PERIODIC BREATHING IN HEART FAILURE | 227 | ||
| PREVALENCE OF CENTRAL SLEEP APNEA IN HEART FAILURE | 228 | ||
| TREATMENT OF CENTRAL SLEEP APNEA IN HEART FAILURE | 229 | ||
| POSITIVE AIRWAY PRESSURE IN THE TREATMENT OF CENTRAL SLEEP APNEA IN HEART FAILURE | 229 | ||
| TRANSVENOUS PHRENIC NERVE STIMULATION FOR TREATMENT OF CENTRAL SLEEP APNEA IN HEART FAILURE | 231 | ||
| OPIOIDS-INDUCED CENTRAL SLEEP APNEA | 233 | ||
| TREATMENT OPTIONS FOR OPIOID-INDUCED CENTRAL SLEEP APNEA | 234 | ||
| Positive Airway Pressure Devices | 234 | ||
| AMPAKINE THERAPY FOR COUNTERING CENTRAL RESPIRATORY DEPRESSION | 234 | ||
| Respiratory Neural Control and the Importance of Amino-3-hydroxy-5-methyl-4-isoxazolepropionate Receptor Activation | 235 | ||
| Preclinical Rodent Data Demonstrating the Efficacy of Ampakines for Countering Opioid-Induced Respiratory Depression | 235 | ||
| In Vitro Rodent Studies | 235 | ||
| In Vivo Rodent Studies | 236 | ||
| Translational Human Data Demonstrating the Efficacy of Ampakines for Countering Opioid-Induced Respiratory Depression | 236 | ||
| Additional Applications of Ampakines for Alleviating Respiratory Depression | 236 | ||
| SUMMARY | 236 | ||
| REFERENCES | 237 | ||
| The Role of Big Data in the Management of Sleep-Disordered Breathing | 241 | ||
| Key points | 241 | ||
| INTRODUCTION | 241 | ||
| CAUSE AND GENETIC PREDISPOSITION | 243 | ||
| DIAGNOSIS | 244 | ||
| MANAGEMENT | 245 | ||
| COMPLICATIONS OF OBSTRUCTIVE SLEEP APNEA | 247 | ||
| ASSOCIATIONS WITH OTHER DISORDERS | 247 | ||
| DEVELOPING BIG DATA RESOURCES | 248 | ||
| ELECTRONIC HEALTH RECORD DATA | 249 | ||
| SLEEP MEDICINE BIG DATA RESOURCES | 250 | ||
| LIMITATIONS AND CHALLENGES | 252 | ||
| SUMMARY | 253 | ||
| REFERENCES | 253 | ||
| Advances and New Approaches to Managing Sleep-Disordered Breathing Related to Chronic Pulmonary Disease | 257 | ||
| Key points | 257 | ||
| INTRODUCTION | 257 | ||
| SLEEP PHYSIOLOGY, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, AND SLEEP-DISORDERED BREATHING | 258 | ||
| REVIEW OF RECENT DATA REGARDING NOCTURNAL NONINVASIVE VENTILATION ON PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 258 | ||
| VOLUME TARGET NONINVASIVE VENTILATION FOR HYPERCAPNIA IN CHRONIC RESPIRATORY FAILURE | 260 | ||
| NONINVASIVE VENTILATION REIMBURSEMENT ISSUES | 260 | ||
| RECOMMENDATION FOR REVISION OF CURRENT GUIDELINE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE TREATMENT WITH NONINVASIVE VENTIL ... | 262 | ||
| HIGH-FLOW HUMIDIFIED OXYGEN DELIVERY DEVICES | 262 | ||
| RESPIRATORY STIMULANTS DRUGS FOR CHRONIC RESPIRATORY FAILURE | 262 | ||
| SUMMARY | 263 | ||
| REFERENCES | 263 |