Additional Information
Book Details
Abstract
Employing a systematic pattern recognition approach, Practical Cytopathology: A Diagnostic Approach equips you to achieve a more accurate diagnosis of aspirated and exfolliative tissue samples from all available body organs and sites. Part of the popular Pattern Recognition Series, this volume is designed to successfully guide you from identification of the dominant cytopathologic pattern, through the appropriate work-up, around the pitfalls, to the best diagnosis.
- A practical, pattern-based organization helps you to efficiently and confidently formulate accurate diagnoses at the microscope.
- A unique Visual Index at the beginning of the book allows you to compare specimens to commonly seen patterns, categorize them accordingly, and turn directly to in-depth diagnostic guidance.
- Lavishly illustrated with more than 1200 high-quality, full-color images that depict the full range of common and rare conditions.
- Ideal for both general surgical pathologists and cytopathologists, no other single source delivers such highly practical, hands-on information needed to solve even the toughest diagnostic challenges in aspiration and exfolliative cytology.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| IFC | ES1 | ||
| Practical Cytopathology: A Diagnostic Approach\rto Fine Needle Aspiration Biopsy | i | ||
| Series page | ii | ||
| Practical Cytopathology: A Diagnostic Approach to Fine Needle Aspiration Biopsy | iii | ||
| Copyright | iv | ||
| Contributors | v | ||
| Series Preface | vii | ||
| Preface | ix | ||
| Contents | xi | ||
| 1 - Introduction to the Practical Algorithmic Pattern Recognition Approach to Fine Needle Aspiration Biopsy | 1 | ||
| FNAB Pattern Recognition | 1 | ||
| Deconstructive Cytology | 2 | ||
| FNAB Interpretation Is Similar to Bird Identification | 2 | ||
| Importance of Optimal FNAB Technique and Smear Preparation | 2 | ||
| Example of the Algorithmic Pattern-Based Approach to FNAB | 2 | ||
| How to Use This Book | 3 | ||
| Review of the Algorithmic Pattern Recognition Approach | 3 | ||
| 2 - Fine Needle Aspiration Biopsy Cytology of Salivary Gland: A Diagnostic Approach Based on Pattern Recognition | 5 | ||
| FNAB Smear Patterns | 5 | ||
| 1. Mixed Inflammatory Pattern (Plate 2-1) | 5 | ||
| 2. Lymphocyte-Only Pattern (Plate 2-2) | 5 | ||
| 3. Epithelial Proliferations and Neoplasms Without Myoepithelial Stromal Component (Plate 2-3) | 18 | ||
| 4. Epithelial Neoplasms With Abundant Myoepithelial Stromal Component (Plate 2-4) | 18 | ||
| 5. Epithelial Neoplasms With Scant Myoepithelial Stromal Component (Plate 2-5) | 18 | ||
| 6. Epithelial Proliferations and Neoplasms Associated With a Lymphoid Background (Plate 2-6)\r | 18 | ||
| I. Non-Neoplastic Entities | 18 | ||
| Normal Salivary Gland | 18 | ||
| Acute Sialadenitis | 18 | ||
| Clinical Features | 18 | ||
| 3 - Fine Needle Aspiration Biopsy Cytology of Lymph Nodes: A Diagnostic Approach Based on Pattern Recognition | 53 | ||
| Smear Patterns: Specific Lesions and Their Cytopathological Criteria | 53 | ||
| 1. Dispersed Hypercellular Pattern (Plates 3-1A-C) | 53 | ||
| 2. Dispersed Hypocellular Pattern (Plates 3-2A-C) | 66 | ||
| 3. Hypercellular Mixed Dispersed and Tissue Fragment Pattern (Plates 3-3A-C) | 66 | ||
| 4. Hypocellular Mixed Dispersed and Tissue Fragment Pattern (Plates 3-4A-C) | 66 | ||
| 5. Predominantly Tissue Fragmented Pattern (Plates 3-5A-C) | 66 | ||
| 6. Spindle Cell Pattern (Plates 3-6A-B) | 66 | ||
| Reactive, Nonspecific Lymphoid Hyperplasia | 66 | ||
| Clinical Features | 66 | ||
| Cytopathology | 66 | ||
| Differential Diagnosis | 67 | ||
| Ancillary Diagnostic Studies | 67 | ||
| Castleman Disease | 68 | ||
| Clinical Features | 68 | ||
| Cytopathology | 68 | ||
| Differential Diagnosis | 69 | ||
| Ancillary Diagnostic Studies | 69 | ||
| Toxoplasmic Lymphadenitis | 69 | ||
| Clinical Features | 69 | ||
| Cytopathology | 69 | ||
| 4 - Fine Needle Aspiration Biopsy Cytology of Thyroid: A Diagnostic Approach Based on Pattern Recognition | 91 | ||
| Thyroid FNAB Accuracy | 91 | ||
| Thyroid FNAB Technique | 91 | ||
| Thyroid FNAB: Criteria for Adequate Smear | 92 | ||
| Thyroid FNAB Request Form | 92 | ||
| Thyroid FNAB Diagnostic Terminologies | 93 | ||
| Ancillary Studies of Thyroid FNAB | 93 | ||
| I. Protein-Based Analysis (Immunohistochemistry) | 94 | ||
| II. Mutation Analysis | 94 | ||
| III. Gene Expression Analysis | 94 | ||
| IV. miRNA Analysis | 94 | ||
| V. Targeted next-generation sequencing panel (ThyroSeq) | 94 | ||
| Smear Patterns: Specific Lesions and Their Cytopathological Criteria | 95 | ||
| Thyroid Fine Needle Biopsy: Normal Components | 112 | ||
| Cytopathology | 112 | ||
| Suppurative Thyroiditis | 112 | ||
| 5 - Fine Needle Aspiration Biopsy Cytology of Breast: A Diagnostic Approach Based on Pattern Recognition | 147 | ||
| Roles of FNAB and Core Biopsies | 147 | ||
| Role of FNAB in Young Women | 148 | ||
| Role of FNAB of Axillary Lymph Nodes in Women With Breast Lesions | 148 | ||
| Breast FNAB Report | 148 | ||
| Adequacy in FNAB of Breast | 149 | ||
| Techniques and Stains | 149 | ||
| An Approach to Reporting FNAB Breast Slides | 149 | ||
| Step 1: Low-Power Assessment: Cellularity and Smear Pattern (x2 to x20) | 150 | ||
| 1. Cellularity | 150 | ||
| 2. Smear Patterns | 150 | ||
| Pattern 1. Predominantly Small Cohesive Epithelial Tissue Fragments with Myoepithelial Cells and Bare Bipolar Nuclei (Plate 5-1;... | 151 | ||
| Pattern 2. Proteinaceous Background (Plate 5-2; Figs. 5-11 to 5-13) | 151 | ||
| Pattern 4. Predominantly Large Epithelial Tissue Fragments, a Variable Number of Discohesive Smaller Epithelial Tissue Fragments... | 176 | ||
| Pattern 5. Predominantly Small Discohesive Epithelial Tissue Fragments With Plentiful Dispersed Cells (Plate 5-5; Figs. 5-18 to ... | 176 | ||
| Pattern 6. Dispersed Cells (Plate 5-6; Figs. 5-21 to 5-23) | 176 | ||
| Pattern 7. Prominent Necrosis (Plate 5-7; Fig. 5-24) | 176 | ||
| Pattern 8. Mucinous Background (Plate 5-8; Figs. 5-25 to 5-26) | 176 | ||
| Step 2: High-Power Assessment (×40) | 176 | ||
| Specific Lesions and Their Cytopathological Criteria | 180 | ||
| Cysts and Related Lesions | 180 | ||
| Clinical Features | 180 | ||
| Cytopathology | 180 | ||
| Granular Cell Tumor | 184 | ||
| Clinical Features | 184 | ||
| Cytopathology | 185 | ||
| Ancillary Diagnostic Tests | 186 | ||
| Fibrocystic Change | 186 | ||
| Clinical Features | 186 | ||
| Cytopathology | 186 | ||
| Differential Diagnosis | 186 | ||
| Epithelial Hyperplasia | 187 | ||
| Clinical Features | 187 | ||
| Cytopathology | 187 | ||
| Differential Diagnosis | 188 | ||
| Radial Scars/Complex Sclerosing Lesions | 191 | ||
| Clinical Features | 191 | ||
| Cytopathology | 191 | ||
| Differential Diagnosis | 191 | ||
| Fibroadenoma | 192 | ||
| Clinical Features | 192 | ||
| Cytopathology | 192 | ||
| Differential Diagnosis | 194 | ||
| Adenomyoepithelioma | 195 | ||
| Clinical Features | 195 | ||
| Cytopathology | 195 | ||
| 6 - Fine Needle Aspiration Biopsy Cytology of Liver: A Diagnostic Approach Based on Pattern Recognition | 233 | ||
| FNAB of Liver: Radiologist’s Perspective | 233 | ||
| Approach to FNAB Diagnosis | 234 | ||
| Pattern Recognition: Specific Lesions and Their Cytopathological Criteria | 234 | ||
| Pattern 1: Background Predominant (Plates 6-1A and B; Figs. 6-1 to 6-4) | 235 | ||
| Pattern 2: Mildly Cellular With Small Tissue Fragments (Plates 6-2A and B; Figs. 6-5 and 6-6) | 235 | ||
| Pattern 3: Moderately to Markedly Cellular With Tissue Fragments Ranging From Small to Large Without Dispersal (Plates 6-3A and ... | 235 | ||
| Pattern 4: Moderately to Markedly Cellular With Tissue Fragments Ranging From Small to Large and Dispersed Cells (Plates 6-4A an... | 235 | ||
| Pattern 5: Moderately to Markedly Cellular With Dispersed Cells (Plates 6-5A and B; Figs. 6-15 and 6-16) | 235 | ||
| Normal Liver | 235 | ||
| 7 - Fine Needle Aspiration Biopsy Cytology of Pancreas: A Diagnostic Approach Based on Pattern Recognition | 277 | ||
| Integrative Approach to Pancreatic FNAB | 277 | ||
| Indications for Pancreatic FNAB | 277 | ||
| Specimen Preparation | 277 | ||
| Cytologic Approach to Assessing Pancreatic FNAB | 278 | ||
| Low- to Intermediate-Power Assessment | 278 | ||
| High-Power Assessment | 279 | ||
| Patterns in Pancreatic FNAB Smears | 281 | ||
| 1. Inflammatory Cells Predominating With or Without Epithelial Tissue Fragments (Plate 7-1) | 281 | ||
| 2. Mucinous Background (Plate 7-2) | 281 | ||
| 3. Dirty or Necrotic Background Predominating (Plate 7-3) | 281 | ||
| 4. Predominantly Cohesive Epithelial or Ductal-Type Tissue Fragments (Plate 7-4) | 281 | ||
| 5. Loosely Cohesive Tissue Fragments With Predominantly Dispersed Single Cells (Plate 7-5) | 281 | ||
| 6. Epithelial Proliferations With Fibrovascular Stroma or Cores Within Epithelial Tissue Fragments (Plate 7-6) | 281 | ||
| 7. Squamous Cells Predominating (Plate 7-7) | 281 | ||
| 8. Stromal Fragments With or Without Epithelial Tissue Fragments (Plate 7-8) | 281 | ||
| Normal Pancreas | 281 | ||
| Contaminants From Percutaneous FNAB | 298 | ||
| Mesothelial Cells | 298 | ||
| Hepatocytes | 298 | ||
| Abscess | 299 | ||
| Clinical Features | 299 | ||
| 8 - Fine Needle Aspiration Biopsy Cytology of Lung and Mediastinum: A Diagnostic Approach Based on Pattern Recognition | 329 | ||
| Endobronchoscopic FNAB of Lung and Mediastinum | 329 | ||
| Rapid On-Site Evaluation | 330 | ||
| Adequacy and Reporting | 330 | ||
| Ancillary Techniques | 330 | ||
| Molecular Pathology of Lung Carcinomas | 331 | ||
| Diagnostic Patterns in FNAB of Lung and Mediastinum | 332 | ||
| Pattern 8-1: Inflammatory Cells Predominate | 332 | ||
| Pattern 8-2: Dispersed Lymphoid Cells | 332 | ||
| Pattern 8-3: Epithelial Tissue Fragments With or Without Glandular Differentiation and With a Variable Number of Dispersed Cells... | 332 | ||
| Pattern 8-4: Epithelial Tissue Fragments and Plentiful Dispersed Cells Showing Varying Degrees of Squamous Differentiation With ... | 332 | ||
| Pattern 8-5: Predominantly Dispersed Cells With Discohesive Epithelial Tissue Fragments With or Without Chromatin Smearing and K... | 332 | ||
| Pattern 8-6: Small Loosely Cohesive Epithelial Tissue Fragments and Dispersed Cells and Scattered Thin Capillary Networks | 332 | ||
| Pattern 8-7: Stromal and Epithelial Components | 332 | ||
| Pattern 8-8 Stromal Components Without Epithelium | 332 | ||
| Acute Pneumonia | 332 | ||
| Clinical | 332 | ||
| Cytopathology | 333 | ||
| Ancillary Diagnostic Studies | 351 | ||
| Organizing Pneumonia | 351 | ||
| Clinical | 351 | ||
| Cytopathology | 351 | ||
| Ancillary Diagnostic Studies | 353 | ||
| Granulomatous Lesions | 353 | ||
| Clinical | 353 | ||
| Cytopathology | 353 | ||
| Ancillary Diagnostic Studies | 358 | ||
| Lymphomas and Leukemias | 358 | ||
| Clinical | 358 | ||
| Cytopathology | 358 | ||
| Differential Diagnosis | 360 | ||
| Carcinoma of the Lung | 360 | ||
| Adenocarcinoma of Lung | 360 | ||
| Clinical | 360 | ||
| Cytopathology | 361 | ||
| Differential Diagnosis | 361 | ||
| Diagnostic Ancillary Studies | 366 | ||
| Squamous Cell Carcinoma | 367 | ||
| Clinical | 367 | ||
| Cytopathology | 367 | ||
| Differential Diagnosis | 369 | ||
| Ancillary Diagnostic Studies | 370 | ||
| Large Cell “Undifferentiated” Carcinoma | 370 | ||
| Clinical | 370 | ||
| Cytopathology | 370 | ||
| Differential Diagnosis | 370 | ||
| Ancillary Diagnostic Studies | 371 | ||
| Small Cell Neuroendocrine Carcinoma | 372 | ||
| Clinical | 372 | ||
| Cytopathology | 372 | ||
| Differential Diagnosis | 372 | ||
| Diagnostic Ancillary Studies | 373 | ||
| Carcinoid Tumors | 374 | ||
| Clinical | 374 | ||
| Cytopathology | 374 | ||
| Differential Diagnosis | 376 | ||
| Diagnostic Ancillary Studies | 377 | ||
| Pulmonary Hamartomas | 377 | ||
| Clinical | 377 | ||
| Cytopathology | 377 | ||
| Differential Diagnosis | 378 | ||
| 9 - Fine Needle Aspiration Biopsy Cytology of Kidney: A Diagnostic Approach Based on Pattern Recognition | 389 | ||
| Indications | 389 | ||
| Adequacy | 390 | ||
| Role of Immunohistochemistry | 391 | ||
| Patterns in FNAB of Kidney: Specific Lesions and Their Cytopathological Criteria | 392 | ||
| Pattern 1: Mixed Small Tissue Fragments in Clean Background With or Without Glomeruli | 392 | ||
| Pattern 2: Cystic Proteinaceous Background With Variable Number of Macrophages | 392 | ||
| Pattern 3: Predominantly Dispersed Inflammatory Cells | 392 | ||
| Pattern 5: Loosely Cohesive Papillary Tissue Fragments and Dispersed Cells With or Without a Hemorrhagic and/or Necrotic Backgro... | 392 | ||
| Pattern 6: Loosely Cohesive Tissue Fragments With Dispersed Atypical Cells, With or Without Necrosis and Hemorrhage | 392 | ||
| Pattern 7: Dispersed Atypical Small Round Cells With Variable Mix of Discohesive Tissue Fragments of Epithelial or Spindle Cells... | 392 | ||
| Pattern 8: Mixed Cohesive Tissue Fragments of Spindle Cells and Vessels, With Fatty Globules and Spindle Cells in Bloody Backgro... | 392 | ||
| Kidney: Normal Components | 392 | ||
| Cytopathology | 392 | ||
| Metanephric (Embryonal) Adenoma | 410 | ||
| 10 - Fine Needle Aspiration Biopsy Cytology of Soft Tissue: A Diagnostic Approach Based on Pattern Recognition | 441 | ||
| Smear Patterns | 441 | ||
| 1. Well-Differentiated Fat Tissue Fragments With or WIthout Spindle Cell Component | 454 | ||
| Lipoma | 454 | ||
| 11 - Intraoperative Cytology of Central Nervous System Lesions: A Diagnostic Approach Based on Pattern Recognition | 483 | ||
| Definition of “Practical Pattern Recognition−Based Approach” to Intraoperative Central Nervous System Cytology | 483 | ||
| Method of Central Nervous System Squash Preparation | 484 | ||
| Advantages and Limitations of Cytologic Smear Preparation | 484 | ||
| Cytologic Smears: Advantages | 484 | ||
| Cytologic Smears: Limitations | 484 | ||
| Normal Central Nervous System Constituents and Associated Pathologic Reactions | 484 | ||
| Neurons | 484 | ||
| Pathologic Reactions | 484 | ||
| Astrocytes | 484 | ||
| Index | 535 | ||
| A | 535 | ||
| B | 536 | ||
| C | 536 | ||
| D | 538 | ||
| E | 538 | ||
| F | 539 | ||
| G | 540 | ||
| H | 540 | ||
| I | 541 | ||
| J | 541 | ||
| K | 541 | ||
| L | 541 | ||
| M | 542 | ||
| N | 543 | ||
| O | 544 | ||
| P | 544 | ||
| R | 545 | ||
| S | 546 | ||
| T | 547 | ||
| U | 547 | ||
| V | 547 | ||
| W | 547 | ||
| X | 548 | ||
| Z | 548 | ||
| IBC | ES2 |