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Book Details
Abstract
This new edition examines the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. It is concise, yet covers all of the organ systems in which the procedure is used, with the number of pages devoted to each body site proportional to the clinical relevance of cytology for that site. Inside, you’ll find new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures. Over 700 full-color illustrations provide you with a real-life perspective of a full range of cytologic findings. Each chapter includes a discussion of indications and methods, along with a section on differential diagnosis accompanied by ancillary diagnostic techniques such as immunohistochemistry and molecular biology, where appropriate.
- Offers comprehensive coverage of everyday diagnostic work in a concise format for a practical benchside manual.
- Covers every type of cytology—gynecology, non-gynecology, and FNA.
- Presents an in-depth differential diagnosis discussion for all major entities.
- Examines the role of special techniques such as immunohistochemistry, flow cytometry, and molecular biology in resolving difficulties in interpretation and diagnosis.
- Provides an in-depth analysis of common diagnostic pitfalls to assist with daily signing out and reporting.
- Features coverage of patient management in discussions of pertinent clinical features.
- Uses capsule summaries featuring easy-to-read bulleted text that provide a quick review of key differential diagnoses, diagnostic pitfalls, cytomorphologic features, and tissue acquisition protocols for specific entities.
- Includes over 700 full-color illustrations that provide you with a real-life perspective of a full range of cytologic findings.
- Covers automated cytology and HPV testing in Cervical and Vaginal Cytology chapter, providing an up-to-date reference on the techniques used in today’s labs.
- Offers new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures.
- Discusses the implementation of proficiency testing and changes in laboratory inspection and accreditation.
- Includes recommendations from the 2008 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Cytology Diagnostic Principles and Clinical Correlates | iii | ||
| Copyright Page | iv | ||
| Dedication Page | v | ||
| Preface to Third Edition | vii | ||
| Contributors | ix | ||
| Acknowledgments | xi | ||
| Contents | xiii | ||
| Chapter 1: Cervical and Vaginal Cytology | 1 | ||
| The History of the Pap Test | 2 | ||
| Sampling and Preparation Methods | 3 | ||
| Automated Screening | 6 | ||
| Accuracy and Reproducibility | 8 | ||
| Diagnostic Terminology and Reporting Systems | 8 | ||
| The Bethesda System | 9 | ||
| The Normal Pap | 11 | ||
| Organisms and Infections | 19 | ||
| Benign and Reactive Changes | 24 | ||
| Vaginal Specimens in “DES Daughters” | 29 | ||
| Squamous Abnormalities | 29 | ||
| Glandular Abnormalities | 44 | ||
| Other Malignant Neoplasms | 53 | ||
| Endometrial Cells in Women Older than 40 Years of Age | 55 | ||
| References | 58 | ||
| Chapter 2: Respiratory Tract | 65 | ||
| Normal Anatomy, Histology, and Cytology of the Respiratory Tract | 66 | ||
| Sampling Techniques, Preparation Methods, Reporting Terminology, and Accuracy | 67 | ||
| Benign Cellular Change | 70 | ||
| Noncellular Elements and Specimen Contaminants | 72 | ||
| Infections | 74 | ||
| Non-Neoplastic, Noninfectious Pulmonary Diseases | 79 | ||
| Benign Neoplasms of The Lung | 81 | ||
| Preneoplastic Changes of the Respiratory Epithelium | 82 | ||
| Lung Cancer | 83 | ||
| Uncommon Pulmonary Tumors | 95 | ||
| Metastatic Cancers to the Lung | 97 | ||
| References | 98 | ||
| Chapter 3: Urine and Bladder Washings | 105 | ||
| Specimen Collection | 106 | ||
| Processing | 107 | ||
| Reporting Terminology and Adequacy Criteria | 107 | ||
| Accuracy | 107 | ||
| Normal Elements | 109 | ||
| Benign Lesions | 111 | ||
| Urothelial Neoplasms | 114 | ||
| Other Malignant Lesions | 119 | ||
| Diagnosing Difficult or Borderline Specimens: Common Patterns | 120 | ||
| Ancillary Techniques | 123 | ||
| Summary | 124 | ||
| References | 124 | ||
| Chapter 4: Pleural, Pericardial, and Peritoneal Fluids | 129 | ||
| Specimen Collection, Preparation, and Reporting Terminology | 129 | ||
| Accuracy | 130 | ||
| Benign Elements | 131 | ||
| Non-Neoplastic Conditions | 132 | ||
| Malignant Effusions | 135 | ||
| References | 151 | ||
| Chapter 5: Peritoneal Washings | 155 | ||
| Specimen Collection, Preparation, and Reporting Terminology | 155 | ||
| Accuracy | 156 | ||
| The Normal Peritoneal Washing | 156 | ||
| Benign Conditions | 158 | ||
| Malignant Tumors | 160 | ||
| Monitoring Response to Treatment (“Second-Look Procedures”) | 168 | ||
| References | 169 | ||
| Chapter 6: Cerebrospinal Fluid | 171 | ||
| Anatomy and Physiology | 171 | ||
| Obtaining and Preparing the Specimen | 171 | ||
| Reporting Terminology | 172 | ||
| Accuracy | 173 | ||
| Normal Elements | 173 | ||
| Abnormal Inflammatory Cells | 175 | ||
| Non-Neoplastic Disorders | 176 | ||
| Neoplasms | 180 | ||
| References | 193 | ||
| Chapter 7: Gastrointestinal Tract | 197 | ||
| Clinical Indications | 197 | ||
| Sample Collection and Processing | 198 | ||
| Accuracy | 199 | ||
| Review of Morphologic Findings | 200 | ||
| Esophagus | 200 | ||
| Stomach | 207 | ||
| Duodenum | 214 | ||
| Colon | 215 | ||
| The Anal Pap Test | 216 | ||
| References | 216 | ||
| Chapter 8: Breast | 221 | ||
| Specimen Types | 221 | ||
| Reporting Terminology | 225 | ||
| Evaluation of the Specimen | 226 | ||
| The Normal Breast | 227 | ||
| Benign Conditions | 227 | ||
| Papillary Neoplasms | 235 | ||
| Phyllodes Tumor | 236 | ||
| Breast Cancer | 237 | ||
| Uncommon Breast Tumors | 244 | ||
| Metastatic Tumors | 247 | ||
| References | 248 | ||
| Chapter 9: Thyroid | 255 | ||
| Aspiration Technique and Slide Preparation | 256 | ||
| Terminology for Reporting Results | 257 | ||
| Accuracy | 258 | ||
| Evaluation of the Specimen | 258 | ||
| Benign Conditions | 259 | ||
| Atypical Cells of Undetermined Significance | 268 | ||
| Suspicious for a Follicular Neoplasm | 268 | ||
| Suspicious for a Huumlrthle Cell Neoplasm | 269 | ||
| Malignant Conditions | 271 | ||
| Parathyroid Tumors | 281 | ||
| References | 282 | ||
| Chapter 10: Salivary Gland | 285 | ||
| Rationale, Indications, and Technical Considerations | 285 | ||
| Diagnostic Overview | 286 | ||
| The Normal Aspirate | 288 | ||
| Non-Neoplastic Conditions | 289 | ||
| Benign Neoplasms | 295 | ||
| Carcinomas of Salivary Gland Origin | 303 | ||
| Rare Malignant Neoplasms | 310 | ||
| Other Malignancies | 312 | ||
| Miscellaneous | 314 | ||
| References | 314 | ||
| Chapter 11: Lymph Nodes | 319 | ||
| Technical Aspects | 320 | ||
| Reporting Terminology and Accuracy | 320 | ||
| Ancillary Studies | 321 | ||
| Non-Neoplastic Lesions | 324 | ||
| Neoplasms | 332 | ||
| References | 354 | ||
| Chapter 12: Liver | 359 | ||
| Normal Liver | 359 | ||
| Infections | 361 | ||
| Benign Lesions | 362 | ||
| Malignant Tumors | 366 | ||
| References | 380 | ||
| Chapter 13: Pancreas and Biliary Tree | 385 | ||
| Indications | 385 | ||
| Sampling Techniques | 385 | ||
| Accuracy and Complications | 386 | ||
| Sample Preparation and Reporting Technology | 386 | ||
| Cyst Fluid Analysis | 387 | ||
| Normal Pancreas and \nBile Duct | 388 | ||
| Pancreatitis and Reactive Changes | 389 | ||
| Pseudocyst and Other \nNon-Neoplastic Cysts | 390 | ||
| Ductal Adenocarcinoma | 390 | ||
| Variants of Ductal Adenocarcinoma | 392 | ||
| Acinar Cell Carcinoma | 393 | ||
| Solid-Pseudopapillary Neoplasm | 394 | ||
| Pancreatic Endocrine Neoplasms | 394 | ||
| Serous Cystadenoma | 397 | ||
| Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm | 398 | ||
| Secondary Pancreatic Neoplasms | 399 | ||
| References | 400 | ||
| Chapter 14: Kidney and Adrenal Gland | 403 | ||
| The Kidney | 403 | ||
| The Adrenal Gland | 422 | ||
| References | 427 | ||
| Chapter 15: Ovary | 433 | ||
| Obtaining the Specimen | 434 | ||
| Preparing the Specimen and Reporting Results | 434 | ||
| Accuracy | 434 | ||
| Benign Tumor-Like Lesions of the Ovary | 435 | ||
| Benign Surface Epithelial-Stromal Tumors | 439 | ||
| Malignant Surface Epithelial-Stromal Tumors | 440 | ||
| Germ Cell Tumors | 443 | ||
| Sex Cord-Stromal Tumors | 446 | ||
| Uncommon Primary Ovarian Tumors | 448 | ||
| Metastatic Tumors | 448 | ||
| References | 449 | ||
| Chapter 16: Soft Tissue | 451 | ||
| Specimen Collection and Preparation | 452 | ||
| Ancillary Studies | 452 | ||
| Reporting Terminology | 454 | ||
| Adipocytic or Lipogenic Neoplasms | 454 | ||
| Myxoid Neoplasms | 459 | ||
| Spindle Cell Neoplasms | 466 | ||
| Fibrohistiocytic Neoplasms | 475 | ||
| Round Cell Neoplasms | 477 | ||
| Epithelioid Neoplasms | 481 | ||
| Pleomorphic Neoplasms | 485 | ||
| Non-Neoplastic Soft Tissue Lesions | 487 | ||
| References | 489 | ||
| Chapter 17: Laboratory Management | 495 | ||
| Agencies and Organizations | 495 | ||
| Regulations | 497 | ||
| Laboratory Personnel | 497 | ||
| Policy and Procedure Manuals | 499 | ||
| Workflow | 499 | ||
| Billing | 500 | ||
| Quality Control and Quality Assurance | 510 | ||
| Proficiency Testing | 513 | ||
| Performance Evaluation | 514 | ||
| Safety | 518 | ||
| References | 521 | ||
| Index | 523 |