Additional Information
Book Details
Abstract
This updated 3rd edition of Basic Immunology provides a readable and concise introduction to the workings of the human immune system, with emphasis on clinical relevance. The format makes learning easy with short, easy-to-read chapters, color tables, key point summaries, and review questions in every chapter. You’ll get the latest coverage on regulatory T cells, biology of the Th17 subset of CD4+ T cells, and more. The full-color artwork, comprehensive glossary, and clinical cases are just some of the features that reinforce and test your understanding of how the immune system functions.
- Covers the most up-to-date immunology information including regulatory T cells, and biology of the Th17 subset of CD4+ T cells to keep you completely current.
- Relates basic science to clinical disorders through clinical cases for better application in a real-world setting.
- Provides a full Glossary to keep you on the cutting edge of immunologic terminology.
- Includes appendices summarizing the features of CD Molecules, a handy Glossary, and Clinical Cases that test your understanding of how the immune system functions in health and disease.
- Presents beautiful full-color artwork for enhanced visual learning.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front cover | Cover | ||
| Title page | i | ||
| Copyright page | ii | ||
| PREFACE | v | ||
| Table of contents | vii | ||
| Chapter 1: INTRODUCTION TO THE IMMUNE SYSTEM | 1 | ||
| Innate and Adaptive Immunity | 3 | ||
| Types of Adaptive Immunity | 4 | ||
| Properties of Adaptive Immune Responses | 5 | ||
| Cells of the Immune System | 8 | ||
| Tissues of the Immune System | 13 | ||
| Overview of Immune Responses to Microbes | 18 | ||
| SUMMARY | 21 | ||
| Chapter 2: INNATE IMMUNITY | 23 | ||
| Recognition of Microbes by the Innate Immune System | 24 | ||
| Components of Innate Immunity | 28 | ||
| Evasion of Innate Immunity by Microbes | 40 | ||
| Role of Innate Immunity in Stimulating Adaptive Immune Responses | 40 | ||
| SUMMARY | 42 | ||
| Chapter 3: ANTIGEN CAPTURE AND PRESENTATION TO LYMPHOCYTES | 45 | ||
| Antigens Recognized by T Lymphocytes | 46 | ||
| Capture of Protein Antigens by Antigen-Presenting Cells | 47 | ||
| The Structure and Function of Major Histocompatibility Complex Molecules | 51 | ||
| Processing and Presentation of Protein Antigens | 57 | ||
| Antigens Recognized by B Cells and Other Lymphocytes | 64 | ||
| SUMMARY | 64 | ||
| Chapter 4: ANTIGEN RECOGNITION IN THE ADAPTIVE IMMUNE SYSTEM | 67 | ||
| Antigen Receptors of Lymphocytes | 68 | ||
| Development of Immune Repertoires | 76 | ||
| SUMMARY | 86 | ||
| Chapter 5: CELL-MEDIATED IMMUNE RESPONSES | 89 | ||
| Phases of T Cell Responses | 90 | ||
| Antigen Recognition and Costimulation | 92 | ||
| Biochemical Pathways of T Cell Activation | 98 | ||
| Functional Responses of T Lymphocytes to Antigen and Costimulation | 101 | ||
| SUMMARY | 110 | ||
| Chapter 6: EFFECTOR MECHANISMS OF CELL-MEDIATED IMMUNITY | 113 | ||
| Types of Cell-Mediated Immunity | 113 | ||
| Migration of Effector T Lymphocytes to Sites of Infection | 114 | ||
| Effector Functions of CD4+ Helper T Lymphocytes | 119 | ||
| Effector Functions of CD8+ Cytotoxic T Lymphocytes | 124 | ||
| Resistance of Pathogenic Microbes to Cell-Mediated Immunity | 126 | ||
| SUMMARY | 128 | ||
| Chapter 7: HUMORAL IMMUNE RESPONSES | 131 | ||
| Phases and Types of Humoral Immune Responses | 132 | ||
| Stimulation of B Lymphocytes by Antigen | 135 | ||
| The Function of Helper T Lymphocytes in Humoral Immune Responses to Protein Antigens | 138 | ||
| Antibody Responses to T-Independent Antigens | 147 | ||
| Regulation of Humoral Immune Responses: Antibody Feedback | 149 | ||
| SUMMARY | 150 | ||
| Chapter 8: EFFECTOR MECHANISMS OF HUMORAL IMMUNITY | 153 | ||
| Properties of Antibodies That Determine Their Effector Functions | 154 | ||
| Neutralization of Microbes and Microbial Toxins | 156 | ||
| Opsonization and Phagocytosis | 156 | ||
| Antibody-Dependent Cellular Cytotoxicity | 158 | ||
| IgE- and Eosinophil/Mast Cell–Mediated Reactions | 158 | ||
| Activation of the Complement System | 159 | ||
| Functions of Antibodies at Special Anatomic Sites | 166 | ||
| Evasion of Humoral Immunity by Microbes | 168 | ||
| Vaccination | 169 | ||
| SUMMARY | 170 | ||
| Chapter 9: IMMUNOLOGICAL TOLERANCE AND AUTOIMMUNITY | 173 | ||
| Immunological Tolerance: Significance and Mechanisms | 174 | ||
| Central T Lymphocyte Tolerance | 174 | ||
| Peripheral T Lymphocyte Tolerance | 176 | ||
| B Lymphocyte Tolerance | 181 | ||
| Autoimmunity: Principles and Pathogenesis | 182 | ||
| Genetic Factors in Autoimmunity | 184 | ||
| Role of Infections in Autoimmunity | 185 | ||
| SUMMARY | 187 | ||
| Chapter 10: IMMUNE RESPONSES AGAINST TUMORS AND TRANSPLANTS | 189 | ||
| Immune Responses against Tumors | 190 | ||
| Immune Responses against Transplants | 196 | ||
| SUMMARY | 203 | ||
| Chapter 11: HYPERSENSITIVITY | 205 | ||
| Types of Hypersensitivity Reactions | 206 | ||
| Immediate Hypersensitivity | 206 | ||
| Diseases Caused by Antibodies and Antigen-Antibody Complexes | 213 | ||
| Diseases Caused by T Lymphocytes | 217 | ||
| SUMMARY | 220 | ||
| Chapter 12: CONGENITAL AND ACQUIRED IMMUNODEFICIENCIES | 223 | ||
| Congenital (Primary) Immunodeficiencies | 224 | ||
| Acquired (Secondary) Immunodeficiencies | 230 | ||
| Acquired Immunodeficiency Syndrome | 231 | ||
| SUMMARY | 237 | ||
| SUGGESTED READINGS | 239 | ||
| Appendix\rI: GLOSSARY | 245 | ||
| Appendix\rII: PRINCIPAL FEATURES OF CD MOLECULES | 273 | ||
| Appendix\rIII: CLINICAL CASES | 283 | ||
| INDEX | 293 |