Abstract

Pharmaceutical and fine chemical products are typically synthesised batchwise which is an anomaly since batch processes have a series of practical and economical disadvantages. On the contrary, flow continuous processes present a series of advantages leading to new ways to synthesise chemical products. Flow processes - * enable control reaction parameters more precisely (temperature, residence time, amount of reagents and solvent etc.), leading to better reproducibility, safer and more reliable processes * can be performed more advantageously using immobilized reagents or catalysts * improve the selectivity and productivity of the process and possibly even the stability of the catalyst * offer opportunities for heat exchange and energy conservation as well as an easy separation and recycling of the reactants and products by adequate process design * achieve multistep syntheses by assembling a line of reactors with minimum or no purification in between two reaction steps * can be assured by facile automation * scale-up can be easily conducted by number-up With all the new research activity in manufacturing chemical products, this comprehensive book is very timely, as it summarises the latest trends in organic synthesis. It gives an insight into flow continuous processes, outlining the basic concepts and explaining the terminology of, and systems approach to, process design dealing with both homogeneous and heterogeneous catalysis and mini- or micro-reactors. The book contains case studies, extensive bibliographies and reference lists in each chapter to enable the reader to grasp the contents and to go on to more detailed texts on specific subjects if desired. The book is written by both organic chemists and engineers giving a multidisciplinary vision of the new tools and methodologies in this field. It is essential reading for organic chemists (in industry or academia) working alongside chemical engineers or who want to undertake chemical engineering projects. It will also be of interest for chemical engineers to see how basic engineering concepts are applied in modern organic chemistry.
Santiago V Luis is Professor of organic chemistry at the University Jaume I, Castellon, Spain. Eduardo Garcia-Verdugo is a Research Associate in the Inorganic and Organic Chemistry Department at the University Jaume I, Castellon, Spain. He obtained his Ph.D. degree in organic chemistry and materials science from the University Jaume I, Castellon, Spain. In 2000, Dr Garcia-Verdugo received a post-doctoral Marie Curie Fellowship from the EU commission whilst working at the Clean Technology Group at Nottingham University. In 2004, he was elected for the prestigious Ram¾n y Cajal research program from the Spanish Ministry of Education and Science (MEC). He is also co-author of 41 publications in peer-reviewed, high impact, international chemistry journals and has given 20 communications and 7 lectures in international conferences and Symposia.