Additional Information
Book Details
Abstract
This volume in the highly regarded Diagnostic Pathology series provides a clearer understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer. Diagnostic Pathology: Molecular Oncology is the first reference to apply a practical and clinical approach to examining how molecular mutations affect common medical diseases. Additionally, it identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Easy to use and packed with outstanding illustrations, this is an essential resource for all pathologists or clinicians who need to keep up with the ever-evolving field of molecular medicine.
- Up-to-date information on a variety of topics
- Next-generation sequencing for determining gene mutations
- Diagnostic use of soft tissue mutations
- Use of solid tissue mutations such as EGFR, BRAF, and KRAS for diagnosis and treatment of different carcinomas and melanoma
- Interpreting newly found mutations in hematopathology such as MYD88 mutations
- Understanding bioinformatics
- Guidance on selecting the right test(s) at the right time for the right patient
- Comparisons of molecular testing methods (i.e., FISH testing vs. cytogenetics)
- More than 2,000 images including H&E stains, immunostains, and FISH images
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Diagnostic Pathology: Molecular Oncology | iii | ||
| Copyright Page | iv | ||
| Table of Contents | xiv | ||
| Dedications | v | ||
| Contributing Authors | vi | ||
| Preface | ix | ||
| Acknowledgments | xi | ||
| Sections | xiii | ||
| SECTION 1: Introduction | 1-1 | ||
| CHAPTER 1. STRUCTURE OF CHROMOSOMES AND NUCLEIC ACIDS | 1-2 | ||
| CHROMOSOME ORGANIZATION | 1-2 | ||
| SELECTED REFERENCES | 1-4 | ||
| CHAPTER 2. DNA REPLICATION, TRANSCRIPTION, AND TRANSLATION | 1-6 | ||
| DNA REPLICATION | 1-6 | ||
| TRANSCRIPTION | 1-7 | ||
| TRANSLATION | 1-8 | ||
| SELECTED REFERENCES | 1-8 | ||
| CHAPTER 3. GENE MUTATIONS | 1-10 | ||
| ETIOLOGY/PATHOGENESIS | 1-10 | ||
| TERMINOLOGY, DEFINITIONS, AND CONCEPTS | 1-11 | ||
| NOMENCLATURE | 1-12 | ||
| SELECTED REFERENCES | 1-13 | ||
| SECTION 2: Common Techniques for Analysis of Alterations in Chromosomes and DNA | 2-1 | ||
| CHAPTER 4. CYTOGENETICS AND FISH | 2-2 | ||
| CYTOGENETICS | 2-2 | ||
| FLUORESCENCE IN SITU HYBRIDIZATION | 2-3 | ||
| SELECTED REFERENCES | 2-4 | ||
| CHAPTER 5. CHROMOSOMAL MICROARRAY | 2-6 | ||
| TERMINOLOGY | 2-6 | ||
| METHODS & TECHNIQUES | 2-6 | ||
| CHROMOSOMAL ABERRATIONS | 2-7 | ||
| CLINICAL IMPLICATIONS | 2-7 | ||
| CLINICAL INTERPRETATION | 2-8 | ||
| SELECTED REFERENCES | 2-8 | ||
| CHAPTER 6. AMPLIFICATION METHODS | 2-10 | ||
| TERMINOLOGY | 2-10 | ||
| POLYMERASE CHAIN REACTION | 2-10 | ||
| VARIANTS OF PCR | 2-12 | ||
| SELECTED REFERENCES | 2-13 | ||
| CHAPTER 7. DNA HIGH-RESOLUTION MELTING CURVE ANALYSIS | 2-14 | ||
| TERMINOLOGY | 2-14 | ||
| INTRODUCTION | 2-14 | ||
| PRINCIPLES | 2-14 | ||
| PRE-HRM SPECIMEN PREPARATIONS | 2-15 | ||
| CLINICAL IMPLICATIONS | 2-15 | ||
| INTERPRETATION OF FINDINGS | 2-15 | ||
| SELECTED REFERENCES | 2-15 | ||
| IMAGE GALLERY | 2-15 | ||
| CHAPTER 8. SEQUENCING TECHNOLOGIES | 2-16 | ||
| TERMINOLOGY | 2-16 | ||
| SEQUENCING TECHNIQUES | 2-16 | ||
| SELECTED REFERENCES | 2-17 | ||
| IMAGE GALLERY | 2-17 | ||
| CHAPTER 9. HIGH-THROUGHPUT METHODS IN MOLECULAR PATHOLOGY | 2-18 | ||
| TERMINOLOGY | 2-18 | ||
| NEXT GENERATION SEQUENCING BIOINFORMATICS | 2-18 | ||
| COMPUTATIONAL HARDWARE | 2-18 | ||
| NGS DATA ANALYSIS | 2-18 | ||
| BIOINFORMATICS ANALYSIS | 2-19 | ||
| NGS BIOINFORMATICS | 2-19 | ||
| COMMONLY USED SOFTWARE FOR NGS ANALYSIS | 2-19 | ||
| SELECTED REFERENCES | 2-19 | ||
| CHAPTER 10. DNA METHYLATION ANALYSIS | 2-20 | ||
| TERMINOLOGY | 2-20 | ||
| METHODOLOGY | 2-20 | ||
| CLINICAL IMPLICATIONS | 2-21 | ||
| SELECTED REFERENCES | 2-21 | ||
| SECTION 3. Molecular Genetic Tests in Hematopoietic Tumors | 3-1 | ||
| CHAPTER 11. BCR-ABL1 FUSION GENE | 3-2 | ||
| TERMINOLOGY | 3-2 | ||
| ETIOLOGY/PATHOGENESIS | 3-3 | ||
| CLINICAL IMPLICATIONS | 3-3 | ||
| METHODS OF DETECTION | 3-3 | ||
| DISEASE MONITORING IN Ph(+) CML AND ALL | 3-4 | ||
| BCR-ABL1-RESISTANT MUTATIONS | 3-4 | ||
| SELECTED REFERENCES | 3-4 | ||
| CHAPTER 12. PDGFRA, PDGFRB, AND FGFR1 REARRANGEMENTS DETECTION | 3-6 | ||
| TERMINOLOGY | 3-6 | ||
| ETIOLOGY/PATHOGENESIS | 3-6 | ||
| CLINICAL IMPLICATIONS | 3-6 | ||
| TESTING FOR PDGFRA, PDGFRB, AND FGFR1 REARRANGEMENTS | 3-6 | ||
| DETECTION OF PDGFRA REARRANGEMENT | 3-7 | ||
| DETECTION OF PDGFRB REARRANGEMENT | 3-7 | ||
| DETECTION OF FGFR1 REARRANGEMENT | 3-7 | ||
| SELECTED REFERENCES | 3-7 | ||
| CHAPTER 13. PML-RARA FUSION GENE | 3-8 | ||
| TERMINOLOGY | 3-8 | ||
| ETIOLOGY/PATHOGENESIS | 3-8 | ||
| CLINICAL IMPLICATIONS | 3-9 | ||
| METHODS OF DETECTION | 3-9 | ||
| DISEASE MONITORING IN APL | 3-9 | ||
| SELECTED REFERENCES | 3-9 | ||
| CHAPTER 14. REVERSE TRANSCRIPTION PCR FOR OTHER MYELOID LEUKEMIA TRANSCRIPTS | 3-10 | ||
| RUNX1-RUNX1T1 | 3-10 | ||
| CBFB-MYH11 | 3-10 | ||
| OTHERS | 3-11 | ||
| SELECTED REFERENCES | 3-11 | ||
| CHAPTER 15. FLT3, NPM1, AND CEBPA MUTATIONS | 3-12 | ||
| TERMINOLOGY | 3-12 | ||
| GENE FUNCTION | 3-12 | ||
| GENE MUTATIONS | 3-13 | ||
| CLINICAL IMPLICATIONS | 3-14 | ||
| TESTING FOR FLT3, NPM1, AND CEBPA MUTATIONS | 3-15 | ||
| PREDICTIVE CANCER TESTING SUMMARY | 3-15 | ||
| SELECTED REFERENCES | 3-15 | ||
| CHAPTER 16. JAK2 MUTATIONS AND REARRANGEMENTS | 3-16 | ||
| TERMINOLOGY | 3-16 | ||
| ETIOLOGY/PATHOGENESIS | 3-16 | ||
| CLINICAL IMPLICATIONS | 3-17 | ||
| SELECTED REFERENCES | 3-17 | ||
| CHAPTER 17. MPL MUTATIONS | 3-18 | ||
| TERMINOLOGY | 3-18 | ||
| MOLECULAR CHARACTERISTICS | 3-18 | ||
| CLINICAL IMPLICATIONS | 3-19 | ||
| SELECTED REFERENCES | 3-19 | ||
| CHAPTER 18. CALRETICULIN (CALR) Mutations | 3-20 | ||
| TERMINOLOGY | 3-20 | ||
| CALR GENE FUNCTION | 3-20 | ||
| CALR GENE MUTATIONS | 3-20 | ||
| METHODS OF DETECTION OF CALR GENE MUTATIONS | 3-21 | ||
| CLINICAL IMPLICATIONS OF CALR MUTATIONS | 3-21 | ||
| SELECTED REFERENCES | 3-21 | ||
| IMAGE GALLERY | 3-21 | ||
| CHAPTER 19. CSF3R MUTATIONS | 3-22 | ||
| TERMINOLOGY | 3-22 | ||
| EPIDEMIOLOGY | 3-22 | ||
| ETIOLOGY/PATHOGENESIS | 3-22 | ||
| CLINICAL IMPLICATIONS | 3-23 | ||
| TESTING | 3-23 | ||
| SELECTED REFERENCES | 3-23 | ||
| CHAPTER 20. SETBP1 MUTATIONS | 3-24 | ||
| TERMINOLOGY | 3-24 | ||
| EPIDEMIOLOGY | 3-24 | ||
| ETIOLOGY/PATHOGENESIS | 3-24 | ||
| CLINICAL IMPLICATIONS | 3-25 | ||
| TESTING | 3-25 | ||
| SELECTED REFERENCES | 3-25 | ||
| CHAPTER 21. KIT MUTATIONS | 3-26 | ||
| TERMINOLOGY | 3-26 | ||
| SELECTED REFERENCES | 3-28 | ||
| CHAPTER 22. IDH1 AND IDH2 MUTATIONS | 3-30 | ||
| TERMINOLOGY | 3-30 | ||
| NORMAL GENE FUNCTION | 3-30 | ||
| SOMATIC IDH1 AND IDH2 GENE MUTATIONS | 3-30 | ||
| METHODS OF DETECTION OF IDH1 AND IDH2 GENE MUTATIONS | 3-31 | ||
| CLINICAL IMPLICATIONS OF IDH1 AND IDH2 MUTATIONS | 3-31 | ||
| SELECTED REFERENCES | 3-31 | ||
| CHAPTER 23. OTHER MUTATIONS AND GENE PANEL TESTING IN MYELOID NEOPLASMS | 3-32 | ||
| CLINICAL IMPLICATIONS | 3-32 | ||
| SELECTED REFERENCES | 3-32 | ||
| CHAPTER 24. IMMUNOGLOBULIN HEAVY (IGH) CHAIN GENE REARRANGEMENTS | 3-34 | ||
| TERMINOLOGY | 3-34 | ||
| IMMUNOGLOBULIN STRUCTURE | 3-34 | ||
| OVERVIEW OF B-CELL DEVELOPMENT | 3-34 | ||
| IGH GENE REARRANGEMENTS | 3-35 | ||
| CLONALITY TESTING | 3-36 | ||
| SELECTED REFERENCES | 3-36 | ||
| CHAPTER 25. T-CELL RECEPTOR GAMMA (TRG) AND DELTA (TRD) CHAIN REARRANGEMENTS | 3-38 | ||
| TERMINOLOGY | 3-38 | ||
| T-CELL RECEPTOR (TCR) STRUCTURE | 3-38 | ||
| TRG GENE REARRANGEMENTS | 3-38 | ||
| CLONALITY TESTING | 3-39 | ||
| SELECTED REFERENCES | 3-40 | ||
| CHAPTER 26. T-CELL RECEPTOR BETA (TRB) CHAIN GENE REARRANGEMENTS | 3-42 | ||
| TERMINOLOGY | 3-42 | ||
| T-CELL DEVELOPMENT OVERVIEW | 3-42 | ||
| TRB GENE REARRANGEMENTS | 3-43 | ||
| CLONALITY TESTING | 3-43 | ||
| SELECTED REFERENCES | 3-44 | ||
| CHAPTER 27. SOUTHERN BLOT ANALYSIS OF ANTIGEN RECEPTOR GENES | 3-46 | ||
| TERMINOLOGY | 3-46 | ||
| STEPS IN SOUTHERN BLOT ANALYSIS | 3-46 | ||
| SELECTED REFERENCES | 3-47 | ||
| IMAGE GALLERY | 3-47 | ||
| CHAPTER 28. EBV-ASSOCIATED HUMAN NEOPLASMS | 3-48 | ||
| TERMINOLOGY | 3-48 | ||
| EBV STRUCTURE AND GENOME | 3-48 | ||
| BIOLOGY OF EBV INFECTION | 3-48 | ||
| EBV-ASSOCIATED LYMPHOMAS | 3-49 | ||
| EBV(+) NONLYMPHOID NEOPLASMS | 3-50 | ||
| DETECTION OF EBV BY MOLECULAR TECHNIQUES | 3-51 | ||
| SELECTED REFERENCES | 3-51 | ||
| CHAPTER 29. MYD88 MUTATION | 3-56 | ||
| TERMINOLOGY | 3-56 | ||
| MOLECULAR FEATURES | 3-56 | ||
| CLINICAL IMPLICATIONS | 3-56 | ||
| TESTING FOR MYD88 L265P MUTATION | 3-57 | ||
| DIAGNOSTIC CHECKLIST | 3-57 | ||
| SELECTED REFERENCES | 3-57 | ||
| CHAPTER 30. NOTCH1 MUTATION | 3-58 | ||
| TERMINOLOGY | 3-58 | ||
| NOTCH1 GENE FUNCTIONS | 3-58 | ||
| NOTCH1 GENE MUTATIONS | 3-58 | ||
| CLINICAL IMPLICATIONS | 3-59 | ||
| TESTING | 3-59 | ||
| SELECTED REFERENCES | 3-59 | ||
| CHAPTER 31. EZH2 MUTATION | 3-60 | ||
| TERMINOLOGY | 3-60 | ||
| NORMAL EZH2 GENE FUNCTION | 3-60 | ||
| SOMATIC EZH2 GENE MUTATIONS | 3-60 | ||
| EPIDEMIOLOGY | 3-61 | ||
| METHOD OF DETECTION | 3-61 | ||
| CLINICAL IMPLICATIONS | 3-61 | ||
| SELECTED REFERENCES | 3-63 | ||
| SECTION 4: Molecular Genetic Tests in Solid Tumors, Bone and Soft Tissue Tumors, and CNS Tumors | 4-1 | ||
| CHAPTER 32. ALK GENE REARRANGEMENTS AND MUTATIONS | 4-2 | ||
| TERMINOLOGY | 4-2 | ||
| MOLECULAR FEATURES | 4-2 | ||
| CLINICAL IMPLICATIONS | 4-2 | ||
| TESTING FOR ALK GENE ALTERATIONS | 4-3 | ||
| SELECTED REFERENCES | 4-3 | ||
| CHAPTER 33. FISH FOR ROS1 REARRANGEMENTS | 4-4 | ||
| TERMINOLOGY | 4-4 | ||
| ETIOLOGY/PATHOGENESIS | 4-4 | ||
| CLINICAL IMPLICATIONS | 4-4 | ||
| SELECTED REFERENCES | 4-5 | ||
| CHAPTER 34. RET REARRANGEMENTS | 4-6 | ||
| TERMINOLOGY | 4-6 | ||
| ETIOLOGY/PATHOGENESIS | 4-6 | ||
| CLINICAL IMPLICATIONS | 4-6 | ||
| SELECTED REFERENCES | 4-7 | ||
| CHAPTER 35. FISH FOR MET AMPLIFICATIONS | 4-8 | ||
| TERMINOLOGY | 4-8 | ||
| ETIOLOGY/PATHOGENESIS | 4-8 | ||
| CLINICAL IMPLICATIONS | 4-9 | ||
| TESTING FOR MET AMPLIFICATION | 4-10 | ||
| PREDICTIVE CANCER TESTING SUMMARY | 4-10 | ||
| SELECTED REFERENCES | 4-10 | ||
| CHAPTER 36. FISH FOR ERBB2 (HER2) GENE AMPLIFICATIONS | 4-12 | ||
| TERMINOLOGY | 4-12 | ||
| EPIDEMIOLOGY | 4-12 | ||
| ETIOLOGY/PATHOGENESIS | 4-12 | ||
| CLINICAL IMPLICATIONS | 4-12 | ||
| PREDICTIVE CANCER TESTING SUMMARY | 4-12 | ||
| FISH METHOD FOR ERBB2 AMPLIFICATION | 4-13 | ||
| QUANTITATIVE REAL-TIME PCR FOR EVALUATION OF ERBB2 GENE STATUS | 4-13 | ||
| SELECTED REFERENCES | 4-13 | ||
| CHAPTER 37. KRAS MUTATIONS | 4-14 | ||
| TERMINOLOGY | 4-14 | ||
| MOLECULAR FEATURES | 4-14 | ||
| CLINICAL IMPLICATIONS | 4-15 | ||
| DETECTION OF KRAS GENE MUTATIONS | 4-15 | ||
| SELECTED REFERENCES | 4-15 | ||
| CHAPTER 38. BRAF MUTATIONS | 4-16 | ||
| TERMINOLOGY | 4-16 | ||
| STRUCTURE AND FUNCTIONS OF BRAF PROTEIN | 4-16 | ||
| BRAF GENE ALTERATIONS | 4-16 | ||
| CLINICAL IMPLICATIONS | 4-16 | ||
| DETECTION TECHNIQUES | 4-17 | ||
| SELECTED REFERENCES | 4-17 | ||
| CHAPTER 39. EGFR MUTATIONS | 4-18 | ||
| TERMINOLOGY | 4-18 | ||
| FUNCTION AND STRUCTURE OF EGFR | 4-18 | ||
| EGFR GENE ALTERATIONS | 4-18 | ||
| DETECTION OF EGFR GENE ALTERATIONS | 4-19 | ||
| SELECTED REFERENCES | 4-19 | ||
| CHAPTER 40. TARGETED HOTSPOT GENE PANEL USING MASSIVELY PARALLEL SEQUENCING (NEXT GENERATION SEQUENCING) | 4-20 | ||
| TERMINOLOGY | 4-20 | ||
| BASIC ASPECTS OF HOTSPOT PANELS | 4-20 | ||
| HOTSPOT GENES | 4-20 | ||
| TECHNICAL AND INTERPRETIVE CHALLENGES | 4-21 | ||
| LIMITS OF HOTSPOT APPROACH | 4-21 | ||
| SELECTED REFERENCES | 4-21 | ||
| CHAPTER 41. MGMT PROMOTER GENE METHYLATION ASSAY | 4-26 | ||
| TERMINOLOGY | 4-26 | ||
| ETIOLOGY/PATHOGENESIS | 4-26 | ||
| CLINICAL IMPLICATIONS | 4-26 | ||
| TESTING METHODS | 4-27 | ||
| SELECTED REFERENCES | 4-27 | ||
| SECTION 5: Molecular Pathology of Myeloid Neoplasms | 5-1 | ||
| CHAPTER 42. MOLECULAR WORK-UP OF MYELOID NEOPLASMS | 5-2 | ||
| MOLECULAR/GENETIC TECHNIQUES COMMONLY USED | 5-2 | ||
| PURPOSES OF MOLECULAR ANALYSIS IN MYELOID NEOPLASMS | 5-2 | ||
| LIMITATIONS OF TECHNIQUES | 5-2 | ||
| CHAPTER 43. CHRONIC MYELOGENOUS LEUKEMIA, BCR-ABL1 POSITIVE | 5-4 | ||
| TERMINOLOGY | 5-4 | ||
| ETIOLOGY/PATHOGENESIS | 5-4 | ||
| CLINICAL ISSUES | 5-5 | ||
| MICROSCOPIC PATHOLOGY | 5-5 | ||
| ANCILLARY TESTS | 5-6 | ||
| DIFFERENTIAL DIAGNOSIS | 5-7 | ||
| SELECTED REFERENCES | 5-7 | ||
| CHAPTER 44. CHRONIC NEUTROPHILIC LEUKEMIA | 5-12 | ||
| TERMINOLOGY | 5-12 | ||
| ETIOLOGY/PATHOGENESIS | 5-12 | ||
| CLINICAL ISSUES | 5-12 | ||
| MOLECULAR PATHOLOGY | 5-13 | ||
| MICROSCOPIC PATHOLOGY | 5-13 | ||
| DIFFERENTIAL DIAGNOSIS | 5-14 | ||
| DIAGNOSTIC CHECKLIST | 5-14 | ||
| SELECTED REFERENCES | 5-14 | ||
| CHAPTER 45. POLYCYTHEMIA VERA | 5-16 | ||
| TERMINOLOGY | 5-16 | ||
| ETIOLOGY/PATHOGENESIS | 5-16 | ||
| CLINICAL ISSUES | 5-16 | ||
| MOLECULAR PATHOLOGY | 5-17 | ||
| MICROSCOPIC PATHOLOGY | 5-17 | ||
| ANCILLARY TESTS | 5-18 | ||
| DIFFERENTIAL DIAGNOSIS | 5-18 | ||
| SELECTED REFERENCES | 5-18 | ||
| CHAPTER 46. PRIMARY MYELOFIBROSIS | 5-20 | ||
| TERMINOLOGY | 5-20 | ||
| CLINICAL ISSUES | 5-20 | ||
| MOLECULAR PATHOLOGY | 5-20 | ||
| MICROSCOPIC PATHOLOGY | 5-22 | ||
| ANCILLARY TESTS | 5-22 | ||
| DIFFERENTIAL DIAGNOSIS | 5-22 | ||
| SELECTED REFERENCES | 5-22 | ||
| CHAPTER 47. ESSENTIAL THROMBOCYTHEMIA | 5-24 | ||
| TERMINOLOGY | 5-24 | ||
| ETIOLOGY/PATHOGENESIS | 5-24 | ||
| CLINICAL ISSUES | 5-24 | ||
| MOLECULAR PATHOLOGY | 5-25 | ||
| MICROSCOPIC PATHOLOGY | 5-26 | ||
| DIFFERENTIAL DIAGNOSIS | 5-26 | ||
| SELECTED REFERENCES | 5-26 | ||
| CHAPTER 48. CHRONIC EOSINOPHILIC LEUKEMIA, NOS | 5-28 | ||
| TERMINOLOGY | 5-28 | ||
| CLINICAL ISSUES | 5-28 | ||
| MICROSCOPIC PATHOLOGY | 5-28 | ||
| ANCILLARY TESTS | 5-28 | ||
| DIFFERENTIAL DIAGNOSIS | 5-29 | ||
| SELECTED REFERENCES | 5-29 | ||
| IMAGE GALLERY | 5-29 | ||
| CHAPTER 49. MASTOCYTOSIS | 5-30 | ||
| TERMINOLOGY | 5-30 | ||
| ETIOLOGY/PATHOGENESIS | 5-30 | ||
| CLINICAL ISSUES | 5-30 | ||
| MOLECULAR PATHOLOGY | 5-32 | ||
| MICROSCOPIC PATHOLOGY | 5-32 | ||
| ANCILLARY TESTS | 5-33 | ||
| DIAGNOSTIC CHECKLIST | 5-33 | ||
| SELECTED REFERENCES | 5-33 | ||
| CHAPTER 50. MYELOPROLIFERATIVE NEOPLASMS, UNCLASSIFIABLE | 5-38 | ||
| TERMINOLOGY | 5-38 | ||
| ETIOLOGY/PATHOGENESIS | 5-38 | ||
| CLINICAL ISSUES | 5-38 | ||
| MOLECULAR PATHOLOGY | 5-38 | ||
| MICROSCOPIC PATHOLOGY | 5-39 | ||
| ANCILLARY TESTS | 5-40 | ||
| DIFFERENTIAL DIAGNOSIS | 5-40 | ||
| DIAGNOSTIC CHECKLIST | 5-40 | ||
| REPORTING CRITERIA | 5-40 | ||
| SELECTED REFERENCES | 5-40 | ||
| CHAPTER 51. OVERVIEW AND CLASSIFICATION OF MDS | 5-42 | ||
| TERMINOLOGY | 5-42 | ||
| EPIDEMIOLOGY | 5-42 | ||
| ETIOLOGY/PATHOGENESIS | 5-42 | ||
| CLINICAL IMPLICATIONS | 5-43 | ||
| SELECTED REFERENCES | 5-43 | ||
| CHAPTER 52. REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLASIA | 5-46 | ||
| TERMINOLOGY | 5-46 | ||
| ETIOLOGY/PATHOGENESIS | 5-46 | ||
| CLINICAL ISSUES | 5-46 | ||
| MOLECULAR PATHOLOGY | 5-46 | ||
| MICROSCOPIC PATHOLOGY | 5-47 | ||
| DIFFERENTIAL DIAGNOSIS | 5-47 | ||
| DIAGNOSTIC CHECKLIST | 5-47 | ||
| SELECTED REFERENCES | 5-47 | ||
| CHAPTER 53. REFRACTORY ANEMIA WITH RING SIDEROBLASTS | 5-50 | ||
| TERMINOLOGY | 5-50 | ||
| ETIOLOGY/PATHOGENESIS | 5-50 | ||
| CLINICAL ISSUES | 5-50 | ||
| MOLECULAR PATHOLOGY | 5-51 | ||
| MICROSCOPIC PATHOLOGY | 5-51 | ||
| DIFFERENTIAL DIAGNOSIS | 5-52 | ||
| DIAGNOSTIC CHECKLIST | 5-52 | ||
| SELECTED REFERENCES | 5-52 | ||
| CHAPTER 54. REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA | 5-54 | ||
| TERMINOLOGY | 5-54 | ||
| ETIOLOGY/PATHOGENESIS | 5-54 | ||
| CLINICAL ISSUES | 5-54 | ||
| MOLECULAR PATHOLOGY | 5-55 | ||
| MICROSCOPIC PATHOLOGY | 5-55 | ||
| ANCILLARY TESTS | 5-56 | ||
| DIFFERENTIAL DIAGNOSIS | 5-56 | ||
| DIAGNOSTIC CHECKLIST | 5-56 | ||
| SELECTED REFERENCES | 5-56 | ||
| CHAPTER 55. MYELODYSPLASTIC SYNDROME WITH ISOLATED del(5q) | 5-58 | ||
| TERMINOLOGY | 5-58 | ||
| ETIOLOGY/PATHOGENESIS | 5-58 | ||
| CLINICAL ISSUES | 5-59 | ||
| MOLECULAR PATHOLOGY | 5-59 | ||
| MICROSCOPIC PATHOLOGY | 5-59 | ||
| DIFFERENTIAL DIAGNOSIS | 5-59 | ||
| SELECTED REFERENCES | 5-59 | ||
| CHAPTER 56. MYELODYSPLASTIC SYNDROME, UNCLASSIFIABLE | 5-62 | ||
| TERMINOLOGY | 5-62 | ||
| CLINICAL ISSUES | 5-62 | ||
| MOLECULAR PATHOLOGY | 5-63 | ||
| MICROSCOPIC PATHOLOGY | 5-63 | ||
| ANCILLARY TESTS | 5-64 | ||
| DIFFERENTIAL DIAGNOSIS | 5-64 | ||
| DIAGNOSTIC CHECKLIST | 5-64 | ||
| SELECTED REFERENCES | 5-64 | ||
| CHAPTER 57. CHILDHOOD MYELODYSPLASTIC SYNDROME | 5-66 | ||
| TERMINOLOGY | 5-66 | ||
| CLINICAL ISSUES | 5-66 | ||
| MOLECULAR PATHOLOGY | 5-67 | ||
| MICROSCOPIC PATHOLOGY | 5-68 | ||
| ANCILLARY TESTS | 5-68 | ||
| DIFFERENTIAL DIAGNOSIS | 5-69 | ||
| DIAGNOSTIC CHECKLIST | 5-70 | ||
| SELECTED REFERENCES | 5-70 | ||
| CHAPTER 58. OVERVIEW OF MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS | 5-72 | ||
| TERMINOLOGY | 5-72 | ||
| ETIOLOGY/PATHOGENESIS | 5-72 | ||
| MICROSCOPIC FINDINGS | 5-73 | ||
| DIAGNOSTIC CHECKLIST | 5-73 | ||
| SELECTED REFERENCES | 5-73 | ||
| IMAGE GALLERY | 5-73 | ||
| CHAPTER 59. CHRONIC MYELOMONOCYTIC LEUKEMIA | 5-74 | ||
| TERMINOLOGY | 5-74 | ||
| ETIOLOGY/PATHOGENESIS | 5-74 | ||
| CLINICAL ISSUES | 5-74 | ||
| MOLECULAR PATHOLOGY | 5-75 | ||
| MICROSCOPIC PATHOLOGY | 5-75 | ||
| ANCILLARY TESTS | 5-76 | ||
| DIFFERENTIAL DIAGNOSIS | 5-76 | ||
| DIAGNOSTIC CHECKLIST | 5-76 | ||
| SELECTED REFERENCES | 5-76 | ||
| CHAPTER 60. ATYPICAL CHRONIC MYELOID LEUKEMIA, BCR-ABL1 NEGATIVE | 5-78 | ||
| TERMINOLOGY | 5-78 | ||
| CLINICAL ISSUES | 5-78 | ||
| MOLECULAR PATHOLOGY | 5-78 | ||
| MICROSCOPIC PATHOLOGY | 5-80 | ||
| ANCILLARY TESTS | 5-80 | ||
| DIFFERENTIAL DIAGNOSIS | 5-80 | ||
| SELECTED REFERENCES | 5-80 | ||
| CHAPTER 61. JUVENILE MYELOMONOCYTIC LEUKEMIA | 5-82 | ||
| TERMINOLOGY | 5-82 | ||
| ETIOLOGY/PATHOGENESIS | 5-82 | ||
| CLINICAL ISSUES | 5-82 | ||
| MOLECULAR PATHOLOGY | 5-82 | ||
| MICROSCOPIC PATHOLOGY | 5-83 | ||
| DIFFERENTIAL DIAGNOSIS | 5-83 | ||
| SELECTED REFERENCES | 5-83 | ||
| IMAGE GALLERY | 5-83 | ||
| CHAPTER 62. MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM, UNCLASSIFIABLE | 5-84 | ||
| TERMINOLOGY | 5-84 | ||
| CLINICAL ISSUES | 5-84 | ||
| MOLECULAR PATHOLOGY | 5-84 | ||
| MICROSCOPIC PATHOLOGY | 5-85 | ||
| ANCILLARY TESTS | 5-86 | ||
| DIFFERENTIAL DIAGNOSIS | 5-86 | ||
| DIAGNOSTIC CHECKLIST | 5-86 | ||
| SELECTED REFERENCES | 5-86 | ||
| CHAPTER 63. OVERVIEW OF ACUTE MYELOID LEUKEMIA | 5-88 | ||
| TERMINOLOGY | 5-88 | ||
| EPIDEMIOLOGY | 5-88 | ||
| ETIOLOGY/PATHOGENESIS | 5-89 | ||
| CLINICAL IMPLICATIONS | 5-89 | ||
| WORK-UP OF AML | 5-89 | ||
| MOLECULAR PATHOLOGY | 5-90 | ||
| MICROSCOPIC FINDINGS | 5-91 | ||
| DIAGNOSTIC CHECKLIST | 5-91 | ||
| SELECTED REFERENCES | 5-92 | ||
| CHAPTER 64. ACUTE MYELOID LEUKEMIAS WITH t(8;21); RUNX1-RUNX1T1 | 5-96 | ||
| TERMINOLOGY | 5-96 | ||
| ETIOLOGY/PATHOGENESIS | 5-96 | ||
| CLINICAL ISSUES | 5-97 | ||
| MICROSCOPIC PATHOLOGY | 5-98 | ||
| ANCILLARY TESTS | 5-98 | ||
| DIFFERENTIAL DIAGNOSIS | 5-98 | ||
| SELECTED REFERENCES | 5-98 | ||
| CHAPTER 65. ACUTE MYELOID LEUKEMIA WITH inv(16) OR t(16;16); CBFB-MYH11 | 5-102 | ||
| TERMINOLOGY | 5-102 | ||
| ETIOLOGY/PATHOGENESIS | 5-102 | ||
| CLINICAL ISSUES | 5-103 | ||
| MACROSCOPIC FEATURES | 5-104 | ||
| MICROSCOPIC PATHOLOGY | 5-104 | ||
| ANCILLARY TESTS | 5-104 | ||
| DIFFERENTIAL DIAGNOSIS | 5-104 | ||
| DIAGNOSTIC CHECKLIST | 5-104 | ||
| SELECTED REFERENCES | 5-104 | ||
| CHAPTER 66. ACUTE PROMYELOCYTIC LEUKEMIA WITH t(15;17); PML-RARA | 5-108 | ||
| TERMINOLOGY | 5-108 | ||
| ETIOLOGY/PATHOGENESIS | 5-108 | ||
| CLINICAL ISSUES | 5-108 | ||
| MOLECULAR PATHOLOGY | 5-109 | ||
| MICROSCOPIC PATHOLOGY | 5-110 | ||
| ANCILLARY TESTS | 5-110 | ||
| DIFFERENTIAL DIAGNOSIS | 5-111 | ||
| DIAGNOSTIC CHECKLIST | 5-111 | ||
| SELECTED REFERENCES | 5-111 | ||
| CHAPTER 67. ACUTE MYELOID LEUKEMIA WITH t(9;11); MLLT3-KMT2A | 5-114 | ||
| TERMINOLOGY | 5-114 | ||
| ETIOLOGY/PATHOGENESIS | 5-114 | ||
| CLINICAL ISSUES | 5-115 | ||
| MICROSCOPIC PATHOLOGY | 5-115 | ||
| ANCILLARY TESTS | 5-116 | ||
| DIFFERENTIAL DIAGNOSIS | 5-116 | ||
| SELECTED REFERENCES | 5-116 | ||
| CHAPTER 68. ACUTE MYELOID LEUKEMIA WITH t(6:9); DEK-NUP214 | 5-120 | ||
| TERMINOLOGY | 5-120 | ||
| CLINICAL ISSUES | 5-120 | ||
| MOLECULAR PATHOLOGY | 5-120 | ||
| MICROSCOPIC PATHOLOGY | 5-121 | ||
| ANCILLARY TESTS | 5-121 | ||
| DIFFERENTIAL DIAGNOSIS | 5-121 | ||
| SELECTED REFERENCES | 5-121 | ||
| IMAGE GALLERY | 5-121 | ||
| CHAPTER 69. ACUTE MYELOID LEUKEMIA WITH inv(3) OR t(3;3); RPN1-MECOM | 5-122 | ||
| TERMINOLOGY | 5-122 | ||
| ETIOLOGY/PATHOGENESIS | 5-122 | ||
| CLINICAL ISSUES | 5-122 | ||
| MOLECULAR PATHOLOGY | 5-122 | ||
| MICROSCOPIC PATHOLOGY | 5-123 | ||
| ANCILLARY TESTS | 5-123 | ||
| DIFFERENTIAL DIAGNOSIS | 5-123 | ||
| SELECTED REFERENCES | 5-123 | ||
| IMAGE GALLERY | 5-123 | ||
| CHAPTER 70. ACUTE MYELOID LEUKEMIA WITH t(1;22); RBM15-MKL1 | 5-124 | ||
| TERMINOLOGY | 5-124 | ||
| ETIOLOGY/PATHOGENESIS | 5-124 | ||
| CLINICAL ISSUES | 5-124 | ||
| MICROSCOPIC PATHOLOGY | 5-125 | ||
| ANCILLARY TESTS | 5-125 | ||
| DIFFERENTIAL DIAGNOSIS | 5-125 | ||
| SELECTED REFERENCES | 5-125 | ||
| IMAGE GALLERY | 5-125 | ||
| CHAPTER 71. ACUTE MYELOID LEUKEMIA WITH MYELODYSPLASIA-RELATED CHANGES | 5-126 | ||
| TERMINOLOGY | 5-126 | ||
| ETIOLOGY/PATHOGENESIS | 5-126 | ||
| CLINICAL ISSUES | 5-126 | ||
| ANCILLARY TESTS | 5-126 | ||
| DIFFERENTIAL DIAGNOSIS | 5-127 | ||
| SELECTED REFERENCES | 5-127 | ||
| IMAGE GALLERY | 5-127 | ||
| CHAPTER 72. ACUTE MYELOID LEUKEMIA, NOS | 5-128 | ||
| TERMINOLOGY | 5-128 | ||
| CLINICAL ISSUES | 5-128 | ||
| MICROSCOPIC PATHOLOGY | 5-128 | ||
| ANCILLARY TESTS | 5-130 | ||
| DIFFERENTIAL DIAGNOSIS | 5-131 | ||
| SELECTED REFERENCES | 5-131 | ||
| CHAPTER 73. THERAPY-RELATED MYELOID NEOPLASMS | 5-134 | ||
| TERMINOLOGY | 5-134 | ||
| ETIOLOGY/PATHOGENESIS | 5-134 | ||
| CLINICAL ISSUES | 5-135 | ||
| MOLECULAR PATHOLOGY | 5-135 | ||
| MICROSCOPIC PATHOLOGY | 5-136 | ||
| ANCILLARY TESTS | 5-136 | ||
| DIFFERENTIAL DIAGNOSIS | 5-136 | ||
| DIAGNOSTIC CHECKLIST | 5-136 | ||
| SELECTED REFERENCES | 5-136 | ||
| CHAPTER 74. MYELOID SARCOMA | 5-138 | ||
| TERMINOLOGY | 5-138 | ||
| ETIOLOGY/PATHOGENESIS | 5-138 | ||
| CLINICAL ISSUES | 5-138 | ||
| MOLECULAR PATHOLOGY | 5-139 | ||
| MICROSCOPIC PATHOLOGY | 5-140 | ||
| ANCILLARY TESTS | 5-140 | ||
| DIFFERENTIAL DIAGNOSIS | 5-140 | ||
| DIAGNOSTIC CHECKLIST | 5-140 | ||
| SELECTED REFERENCES | 5-140 | ||
| CHAPTER 75. DOWN SYNDROME-RELATED MYELOID PROLIFERATIONS | 5-142 | ||
| TERMINOLOGY | 5-142 | ||
| ETIOLOGY/PATHOGENESIS | 5-142 | ||
| CLINICAL ISSUES | 5-143 | ||
| MOLECULAR PATHOLOGY | 5-143 | ||
| MICROSCOPIC PATHOLOGY | 5-144 | ||
| ANCILLARY TESTS | 5-144 | ||
| DIFFERENTIAL DIAGNOSIS | 5-144 | ||
| DIAGNOSTIC CHECKLIST | 5-144 | ||
| SELECTED REFERENCES | 5-144 | ||
| CHAPTER 76. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM | 5-146 | ||
| TERMINOLOGY | 5-146 | ||
| ETIOLOGY/PATHOGENESIS | 5-146 | ||
| CLINICAL ISSUES | 5-146 | ||
| MOLECULAR PATHOLOGY | 5-147 | ||
| MICROSCOPIC PATHOLOGY | 5-147 | ||
| ANCILLARY TESTS | 5-147 | ||
| DIFFERENTIAL DIAGNOSIS | 5-148 | ||
| SELECTED REFERENCES | 5-148 | ||
| SECTION 6: Molecular Pathology of Lymphoid Neoplasms | 6-1 | ||
| CHAPTER 77. OVERVIEW OF LYMPHOID NEOPLASMS | 6-2 | ||
| TERMINOLOGY | 6-2 | ||
| EPIDEMIOLOGY | 6-2 | ||
| ETIOLOGY/PATHOGENESIS | 6-2 | ||
| CLINICAL IMPLICATIONS | 6-3 | ||
| MOLECULAR PATHOLOGY | 6-3 | ||
| ANCILLARY TESTS | 6-4 | ||
| SELECTED REFERENCES | 6-4 | ||
| CHAPTER 78. MOLECULAR WORK-UP OF LYMPHOID NEOPLASMS | 6-6 | ||
| MOLECULAR/GENETIC TECHNIQUES COMMONLY USED | 6-6 | ||
| PURPOSES OF MOLECULARAN ALYSIS | 6-7 | ||
| LIMITATIONS OF TECHNIQUES | 6-7 | ||
| UTILITY OF TESTING METHODS FOR KEY LYMPHOID NEOPLASMS | 6-7 | ||
| CHAPTER 79. B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH RECURRENT GENETIC ABNORMALITIES | 6-8 | ||
| TERMINOLOGY | 6-8 | ||
| ETIOLOGY/PATHOGENESIS | 6-8 | ||
| CLINICAL ISSUES | 6-8 | ||
| MICROSCOPIC PATHOLOGY | 6-9 | ||
| ANCILLARY TESTS | 6-9 | ||
| DIFFERENTIAL DIAGNOSIS | 6-10 | ||
| DIAGNOSTIC CHECKLIST | 6-10 | ||
| SELECTED REFERENCES | 6-10 | ||
| CHAPTER 80. T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA | 6-12 | ||
| TERMINOLOGY | 6-12 | ||
| CLINICAL ISSUES | 6-12 | ||
| MOLECULAR PATHOLOGY | 6-13 | ||
| MICROSCOPIC PATHOLOGY | 6-14 | ||
| ANCILLARY TESTS | 6-15 | ||
| DIFFERENTIAL DIAGNOSIS | 6-15 | ||
| SELECTED REFERENCES | 6-15 | ||
| CHAPTER 81. SMALL LYMPHOCYTIC LYMPHOMA/CHRONIC LYMPHOCYTIC LEUKEMIA | 6-18 | ||
| TERMINOLOGY | 6-18 | ||
| ETIOLOGY/PATHOGENESIS | 6-18 | ||
| CLINICAL ISSUES | 6-19 | ||
| MOLECULAR PATHOLOGY | 6-20 | ||
| MICROSCOPIC PATHOLOGY | 6-22 | ||
| ANCILLARY TESTS | 6-22 | ||
| DIFFERENTIAL DIAGNOSIS | 6-22 | ||
| SELECTED REFERENCES | 6-22 | ||
| CHAPTER 82. B-CELL PROLYMPHOCYTIC LEUKEMIA | 6-24 | ||
| TERMINOLOGY | 6-24 | ||
| ETIOLOGY/PATHOGENESIS | 6-24 | ||
| CLINICAL ISSUES | 6-24 | ||
| MACROSCOPIC FEATURES | 6-25 | ||
| MOLECULAR PATHOLOGY | 6-25 | ||
| MICROSCOPIC PATHOLOGY | 6-25 | ||
| ANCILLARY TESTS | 6-26 | ||
| DIFFERENTIAL DIAGNOSIS | 6-26 | ||
| DIAGNOSTIC CHECKLIST | 6-26 | ||
| SELECTED REFERENCES | 6-26 | ||
| CHAPTER 83. MANTLE CELL LYMPHOMA | 6-28 | ||
| TERMINOLOGY | 6-28 | ||
| ETIOLOGY/PATHOGENESIS | 6-28 | ||
| CLINICAL ISSUES | 6-28 | ||
| IMAGE FINDINGS | 6-29 | ||
| MOLECULAR PATHOLOGY | 6-29 | ||
| MICROSCOPIC PATHOLOGY | 6-30 | ||
| ANCILLARY TESTS | 6-31 | ||
| DIFFERENTIAL DIAGNOSIS | 6-31 | ||
| DIAGNOSTIC CHECKLIST | 6-31 | ||
| SELECTED REFERENCES | 6-31 | ||
| CHAPTER 84. FOLLICULAR LYMPHOMA | 6-34 | ||
| TERMINOLOGY | 6-34 | ||
| ETIOLOGY/PATHOGENESIS | 6-34 | ||
| CLINICAL ISSUES | 6-34 | ||
| MOLECULAR PATHOLOGY | 6-35 | ||
| MICROSCOPIC PATHOLOGY | 6-36 | ||
| ANCILLARY TESTS | 6-37 | ||
| DIFFERENTIAL DIAGNOSIS | 6-37 | ||
| SELECTED REFERENCES | 6-38 | ||
| CHAPTER 85. LYMPHOPLASMACYTIC LYMPHOMA | 6-40 | ||
| TERMINOLOGY | 6-40 | ||
| ETIOLOGY/PATHOGENESIS | 6-40 | ||
| CLINICAL ISSUES | 6-40 | ||
| MOLECULAR PATHOLOGY | 6-41 | ||
| MICROSCOPIC PATHOLOGY | 6-42 | ||
| ANCILLARY TESTS | 6-43 | ||
| DIFFERENTIAL DIAGNOSIS | 6-43 | ||
| SELECTED REFERENCES | 6-44 | ||
| CHAPTER 86. SPLENIC MARGINAL ZONE LYMPHOMA | 6-46 | ||
| TERMINOLOGY | 6-46 | ||
| MACROSCOPIC FEATURES | 6-47 | ||
| MOLECULAR PATHOLOGY | 6-47 | ||
| MICROSCOPIC PATHOLOGY | 6-48 | ||
| ANCILLARY TESTS | 6-48 | ||
| DIFFERENTIAL DIAGNOSIS | 6-48 | ||
| DIAGNOSTIC CHECKLIST | 6-49 | ||
| SELECTED REFERENCES | 6-49 | ||
| CHAPTER 87. SPLENIC DIFFUSE RED PULP SMALL B-CELL LYMPHOMA | 6-52 | ||
| TERMINOLOGY | 6-52 | ||
| CLINICAL ISSUES | 6-52 | ||
| MACROSCOPIC FEATURES | 6-52 | ||
| MOLECULAR PATHOLOGY | 6-52 | ||
| MICROSCOPIC PATHOLOGY | 6-53 | ||
| ANCILLARY TESTS | 6-53 | ||
| DIFFERENTIAL DIAGNOSIS | 6-53 | ||
| SELECTED REFERENCES | 6-54 | ||
| CHAPTER 88. HAIRY CELL LEUKEMIA | 6-56 | ||
| TERMINOLOGY | 6-56 | ||
| ETIOLOGY/PATHOGENESIS | 6-56 | ||
| CLINICAL ISSUES | 6-56 | ||
| MICROSCOPIC PATHOLOGY | 6-57 | ||
| ANCILLARY TESTS | 6-58 | ||
| DIFFERENTIAL DIAGNOSIS | 6-58 | ||
| SELECTED REFERENCES | 6-58 | ||
| CHAPTER 89. HAIRY CELL LEUKEMIA VARIANT | 6-60 | ||
| TERMINOLOGY | 6-60 | ||
| ETIOLOGY/PATHOGENESIS | 6-60 | ||
| CLINICAL ISSUES | 6-60 | ||
| MOLECULAR PATHOLOGY | 6-60 | ||
| MICROSCOPIC PATHOLOGY | 6-60 | ||
| ANCILLARY TESTS | 6-61 | ||
| DIFFERENTIAL DIAGNOSIS | 6-61 | ||
| SELECTED REFERENCES | 6-61 | ||
| CHAPTER 90. DIFFUSE LARGE B-CELL LYMPHOMA | 6-66 | ||
| TERMINOLOGY | 6-66 | ||
| ETIOLOGY/PATHOGENESIS | 6-66 | ||
| CLINICAL ISSUES | 6-66 | ||
| MACROSCOPIC FEATURES | 6-67 | ||
| MOLECULAR PATHOLOGY | 6-67 | ||
| MICROSCOPIC PATHOLOGY | 6-68 | ||
| ANCILLARY TESTS | 6-68 | ||
| DIFFERENTIAL DIAGNOSIS | 6-68 | ||
| DIAGNOSTIC CHECKLIST | 6-69 | ||
| SELECTED REFERENCES | 6-69 | ||
| CHAPTER 91. BURKITT LYMPHOMA | 6-76 | ||
| TERMINOLOGY | 6-76 | ||
| ETIOLOGY/PATHOGENESIS | 6-76 | ||
| CLINICAL ISSUES | 6-77 | ||
| IMAGE FINDINGS | 6-77 | ||
| MACROSCOPIC FEATURES | 6-78 | ||
| MOLECULAR PATHOLOGY | 6-78 | ||
| MICROSCOPIC PATHOLOGY | 6-79 | ||
| ANCILLARY TESTS | 6-79 | ||
| DIFFERENTIAL DIAGNOSIS | 6-80 | ||
| DIAGNOSTIC CHECKLIST | 6-80 | ||
| SELECTED REFERENCES | 6-80 | ||
| CHAPTER 92. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE | 6-84 | ||
| TERMINOLOGY | 6-84 | ||
| ETIOLOGY/PATHOGENESIS | 6-84 | ||
| CLINICAL ISSUES | 6-84 | ||
| IMAGE FINDINGS | 6-85 | ||
| MOLECULAR PATHOLOGY | 6-85 | ||
| MICROSCOPIC PATHOLOGY | 6-86 | ||
| ANCILLARY TESTS | 6-86 | ||
| DIFFERENTIAL DIAGNOSIS | 6-86 | ||
| DIAGNOSTIC CHECKLIST | 6-86 | ||
| SELECTED REFERENCES | 6-86 | ||
| CHAPTER 93. PLASMA CELL MYELOMA | 6-88 | ||
| TERMINOLOGY | 6-88 | ||
| ETIOLOGY/PATHOGENESIS | 6-88 | ||
| CLINICAL ISSUES | 6-89 | ||
| IMAGE FINDINGS | 6-90 | ||
| MOLECULAR PATHOLOGY | 6-90 | ||
| MICROSCOPIC PATHOLOGY | 6-91 | ||
| ANCILLARY TESTS | 6-91 | ||
| DIFFERENTIAL DIAGNOSIS | 6-91 | ||
| SELECTED REFERENCES | 6-91 | ||
| CHAPTER 94. T-CELL PROLYMPHOCYTIC LEUKEMIA | 6-96 | ||
| TERMINOLOGY | 6-96 | ||
| CLINICAL ISSUES | 6-96 | ||
| MOLECULAR PATHOLOGY | 6-96 | ||
| MICROSCOPIC PATHOLOGY | 6-97 | ||
| ANCILLARY TESTS | 6-97 | ||
| DIFFERENTIAL DIAGNOSIS | 6-97 | ||
| CHAPTER 95. CHRONIC LYMPHOPROLIFERATIVE DISORDER OF NK CELLS | 6-100 | ||
| TERMINOLOGY | 6-100 | ||
| ETIOLOGY/PATHOGENESIS | 6-100 | ||
| CLINICAL ISSUES | 6-100 | ||
| MOLECULAR PATHOLOGY | 6-100 | ||
| MICROSCOPIC PATHOLOGY | 6-101 | ||
| ANCILLARY TESTS | 6-101 | ||
| DIFFERENTIAL DIAGNOSIS | 6-101 | ||
| SELECTED REFERENCES | 6-101 | ||
| CHAPTER 96. AGGRESSIVE NK-CELL LEUKEMIA | 6-104 | ||
| TERMINOLOGY | 6-104 | ||
| ETIOLOGY/PATHOGENESIS | 6-104 | ||
| CLINICAL ISSUES | 6-104 | ||
| MOLECULAR PATHOLOGY | 6-104 | ||
| MICROSCOPIC PATHOLOGY | 6-104 | ||
| ANCILLARY TESTS | 6-105 | ||
| DIFFERENTIAL DIAGNOSIS | 6-105 | ||
| SELECTED REFERENCES | 6-105 | ||
| CHAPTER 97. EXTRANODAL NK-/T-CELL LYMPHOMA, NASAL TYPE | 6-108 | ||
| TERMINOLOGY | 6-108 | ||
| ETIOLOGY/PATHOGENESIS | 6-108 | ||
| CLINICAL ISSUES | 6-108 | ||
| IMAGE FINDINGS | 6-109 | ||
| MOLECULAR PATHOLOGY | 6-109 | ||
| MICROSCOPIC PATHOLOGY | 6-109 | ||
| ANCILLARY TESTS | 6-110 | ||
| DIFFERENTIAL DIAGNOSIS | 6-110 | ||
| SELECTED REFERENCES | 6-110 | ||
| CHAPTER 98. ADULT T-CELL LEUKEMIA/LYMPHOMA | 6-112 | ||
| TERMINOLOGY | 6-112 | ||
| ETIOLOGY/PATHOGENESIS | 6-112 | ||
| CLINICAL ISSUES | 6-112 | ||
| MACROSCOPIC FEATURES | 6-113 | ||
| MOLECULAR PATHOLOGY | 6-113 | ||
| MICROSCOPIC PATHOLOGY | 6-113 | ||
| ANCILLARY TESTS | 6-114 | ||
| DIFFERENTIAL DIAGNOSIS | 6-114 | ||
| DIAGNOSTIC CHECKLIST | 6-114 | ||
| SELECTED REFERENCES | 6-114 | ||
| CHAPTER 99. ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA | 6-118 | ||
| TERMINOLOGY | 6-118 | ||
| ETIOLOGY/PATHOGENESIS | 6-118 | ||
| CLINICAL ISSUES | 6-118 | ||
| MACROSCOPIC FEATURES | 6-119 | ||
| MOLECULAR PATHOLOGY | 6-119 | ||
| MICROSCOPIC PATHOLOGY | 6-120 | ||
| ANCILLARY TESTS | 6-120 | ||
| DIFFERENTIAL DIAGNOSIS | 6-120 | ||
| DIAGNOSTIC CHECKLIST | 6-121 | ||
| SELECTED REFERENCES | 6-121 | ||
| CHAPTER 100. HEPATOSPLENIC T-CELL LYMPHOMA | 6-124 | ||
| TERMINOLOGY | 6-124 | ||
| ETIOLOGY/PATHOGENESIS | 6-124 | ||
| CLINICAL ISSUES | 6-124 | ||
| MACROSCOPIC FEATURES | 6-124 | ||
| MOLECULAR PATHOLOGY | 6-124 | ||
| MICROSCOPIC PATHOLOGY | 6-125 | ||
| ANCILLARY TESTS | 6-126 | ||
| DIFFERENTIAL DIAGNOSIS | 6-126 | ||
| SELECTED REFERENCES | 6-126 | ||
| CHAPTER 101. SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA | 6-128 | ||
| TERMINOLOGY | 6-128 | ||
| ETIOLOGY/PATHOGENESIS | 6-128 | ||
| CLINICAL ISSUES | 6-128 | ||
| MOLECULAR PATHOLOGY | 6-129 | ||
| MICROSCOPIC PATHOLOGY | 6-129 | ||
| ANCILLARY TESTS | 6-130 | ||
| DIFFERENTIAL DIAGNOSIS | 6-130 | ||
| SELECTED REFERENCES | 6-130 | ||
| CHAPTER 102. MYCOSIS FUNGOIDES/SEZARY SYNDROME | 6-132 | ||
| TERMINOLOGY | 6-132 | ||
| ETIOLOGY/PATHOGENESIS | 6-132 | ||
| CLINICAL ISSUES | 6-132 | ||
| MACROSCOPIC FEATURES | 6-133 | ||
| MOLECULAR PATHOLOGY | 6-133 | ||
| MICROSCOPIC PATHOLOGY | 6-134 | ||
| ANCILLARY TESTS | 6-134 | ||
| DIFFERENTIAL DIAGNOSIS | 6-134 | ||
| SELECTED REFERENCES | 6-134 | ||
| CHAPTER 103. PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA | 6-136 | ||
| TERMINOLOGY | 6-136 | ||
| ETIOLOGY/PATHOGENESIS | 6-136 | ||
| CLINICAL ISSUES | 6-136 | ||
| MOLECULAR PATHOLOGY | 6-137 | ||
| MICROSCOPIC PATHOLOGY | 6-137 | ||
| ANCILLARY TESTS | 6-138 | ||
| DIFFERENTIAL DIAGNOSIS | 6-138 | ||
| SELECTED REFERENCES | 6-138 | ||
| CHAPTER 104. PERIPHERAL T-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED | 6-140 | ||
| TERMINOLOGY | 6-140 | ||
| ETIOLOGY/PATHOGENESIS | 6-140 | ||
| CLINICAL ISSUES | 6-140 | ||
| IMAGE FINDINGS | 6-141 | ||
| MOLECULAR PATHOLOGY | 6-141 | ||
| MICROSCOPIC PATHOLOGY | 6-142 | ||
| ANCILLARY TESTS | 6-143 | ||
| DIFFERENTIAL DIAGNOSIS | 6-143 | ||
| SELECTED REFERENCES | 6-144 | ||
| CHAPTER 105. ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA | 6-146 | ||
| TERMINOLOGY | 6-146 | ||
| ETIOLOGY/PATHOGENESIS | 6-146 | ||
| CLINICAL ISSUES | 6-146 | ||
| IMAGE FINDINGS | 6-148 | ||
| MOLECULAR PATHOLOGY | 6-148 | ||
| MICROSCOPIC PATHOLOGY | 6-148 | ||
| ANCILLARY TESTS | 6-148 | ||
| DIFFERENTIAL DIAGNOSIS | 6-149 | ||
| DIAGNOSTIC CHECKLIST | 6-149 | ||
| SELECTED REFERENCES | 6-149 | ||
| CHAPTER 106. ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA | 6-152 | ||
| TERMINOLOGY | 6-152 | ||
| ETIOLOGY/PATHOGENESIS | 6-152 | ||
| CLINICAL ISSUES | 6-152 | ||
| MOLECULAR PATHOLOGY | 6-153 | ||
| MICROSCOPIC PATHOLOGY | 6-153 | ||
| ANCILLARY TESTS | 6-154 | ||
| DIFFERENTIAL DIAGNOSIS | 6-154 | ||
| SELECTED REFERENCES | 6-154 | ||
| CHAPTER 107. ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA | 6-158 | ||
| TERMINOLOGY | 6-158 | ||
| ETIOLOGY/PATHOGENESIS | 6-158 | ||
| CLINICAL ISSUES | 6-158 | ||
| MOLECULAR PATHOLOGY | 6-159 | ||
| MICROSCOPIC PATHOLOGY | 6-159 | ||
| ANCILLARY TESTS | 6-160 | ||
| DIFFERENTIAL DIAGNOSIS | 6-160 | ||
| SELECTED REFERENCES | 6-160 | ||
| CHAPTER 108. LYMPHOMA-ASSOCIATED CHROMOSOMAL TRANSLOCATIONS | 6-164 | ||
| TERMINOLOGY | 6-164 | ||
| T(11;14)(Q23;Q32); CCND1-IGH | 6-164 | ||
| T(14;18)(Q32;Q21); IGH-BCL2 | 6-164 | ||
| BCL6 REARRANGEMENTS | 6-165 | ||
| MYC REARRANGEMENTS | 6-165 | ||
| T(11;18)(Q22;Q21); BIRC3-MALT1 | 6-165 | ||
| T(9;14)(P13;Q32); PAX5-IGH | 6-165 | ||
| T(2;5)(P23;Q35); ALK-NPM1 | 6-166 | ||
| DUSP22 REARRANGEMENTS | 6-166 | ||
| TP63 REARRANGEMENTS | 6-166 | ||
| TRA REARRANGEMENTS | 6-166 | ||
| SELECTED REFERENCES | 6-166 | ||
| SECTION 7: Molecular Pathology of Dendritic Cell and Histiocytic Neoplasms | 7-1 | ||
| CHAPTER 109. HISTIOCYTIC SARCOMA | 7-2 | ||
| TERMINOLOGY | 7-2 | ||
| ETIOLOGY/PATHOGENESIS | 7-2 | ||
| CLINICAL ISSUES | 7-2 | ||
| MACROSCOPIC FEATURES | 7-3 | ||
| MOLECULAR PATHOLOGY | 7-3 | ||
| MICROSCOPIC PATHOLOGY | 7-3 | ||
| ANCILLARY TESTS | 7-3 | ||
| DIFFERENTIAL DIAGNOSIS | 7-3 | ||
| SELECTED REFERENCES | 7-4 | ||
| CHAPTER 110. LANGERHANS CELL HISTIOCYTOSIS | 7-10 | ||
| TERMINOLOGY | 7-10 | ||
| ETIOLOGY/PATHOGENESIS | 7-10 | ||
| CLINICAL ISSUES | 7-10 | ||
| IMAGE FINDINGS | 7-11 | ||
| MOLECULAR PATHOLOGY | 7-11 | ||
| MICROSCOPIC PATHOLOGY | 7-12 | ||
| ANCILLARY TESTS | 7-12 | ||
| DIFFERENTIAL DIAGNOSIS | 7-12 | ||
| DIAGNOSTIC CHECKLIST | 7-13 | ||
| SELECTED REFERENCES | 7-13 | ||
| CHAPTER 111. INTERDIGITATING DENDRITIC CELL SARCOMA | 7-16 | ||
| TERMINOLOGY | 7-16 | ||
| ETIOLOGY/PATHOGENESIS | 7-16 | ||
| CLINICAL ISSUES | 7-16 | ||
| IMAGE FINDINGS | 7-17 | ||
| MACROSCOPIC FEATURES | 7-17 | ||
| MOLECULAR PATHOLOGY | 7-17 | ||
| MICROSCOPIC PATHOLOGY | 7-18 | ||
| ANCILLARY TESTS | 7-18 | ||
| DIFFERENTIAL DIAGNOSIS | 7-18 | ||
| SELECTED REFERENCES | 7-18 | ||
| CHAPTER 112. FOLLICULAR DENDRITIC CELL NEOPLASM | 7-20 | ||
| TERMINOLOGY | 7-20 | ||
| ETIOLOGY/PATHOGENESIS | 7-20 | ||
| CLINICAL ISSUES | 7-20 | ||
| MACROSCOPIC FEATURES | 7-21 | ||
| MOLECULAR PATHOLOGY | 7-21 | ||
| MICROSCOPIC PATHOLOGY | 7-21 | ||
| ANCILLARY TESTS | 7-22 | ||
| DIFFERENTIAL DIAGNOSIS | 7-22 | ||
| SELECTED REFERENCES | 7-22 | ||
| SECTION 8: Molecular Pathology of Solid Tumors | 8-1 | ||
| CHAPTER 113. HPV-RELATED SQUAMOUS CELL CARCINOMA | 8-2 | ||
| TERMINOLOGY | 8-2 | ||
| ETIOLOGY/PATHOGENESIS | 8-2 | ||
| CLINICAL ISSUES | 8-2 | ||
| MACROSCOPIC FEATURES | 8-3 | ||
| MOLECULAR PATHOLOGY | 8-3 | ||
| MICROSCOPIC PATHOLOGY | 8-4 | ||
| ANCILLARY TESTS | 8-4 | ||
| DIFFERENTIAL DIAGNOSIS | 8-4 | ||
| DIAGNOSTIC CHECKLIST | 8-4 | ||
| SELECTED REFERENCES | 8-4 | ||
| CHAPTER 114. HEAD AND NECK MUCOSAL SQUAMOUS CELL CARCINOMA, NON-HPV-RELATED | 8-6 | ||
| TERMINOLOGY | 8-6 | ||
| ETIOLOGY/PATHOGENESIS | 8-6 | ||
| CLINICAL ISSUES | 8-7 | ||
| MOLECULAR PATHOLOGY | 8-8 | ||
| MICROSCOPIC PATHOLOGY | 8-8 | ||
| DIFFERENTIAL DIAGNOSIS | 8-9 | ||
| DIAGNOSTIC CHECKLIST | 8-9 | ||
| SELECTED REFERENCES | 8-9 | ||
| CHAPTER 115. IMPORTANT ALTERATIONS IN NON-HPV-RELATED HEAD & NECK SCC | 8-12 | ||
| CHAPTER 116. TRANSLOCATION-SPECIFIC SALIVARY GLAND TUMORS | 8-14 | ||
| TERMINOLOGY | 8-14 | ||
| ETIOLOGY/PATHOGENESIS | 8-14 | ||
| CLINICAL ISSUES | 8-14 | ||
| MOLECULAR PATHOLOGY | 8-16 | ||
| MICROSCOPIC PATHOLOGY | 8-17 | ||
| ANCILLARY TESTS | 8-17 | ||
| DIFFERENTIAL DIAGNOSIS | 8-18 | ||
| DIAGNOSTIC CHECKLIST | 8-18 | ||
| SELECTED REFERENCES | 8-18 | ||
| CHAPTER 117. NASOPHARYNGEAL EBV-RELATED SQUAMOUS CARCINOMA | 8-22 | ||
| TERMINOLOGY | 8-22 | ||
| ETIOLOGY/PATHOGENESIS | 8-22 | ||
| CLINICAL ISSUES | 8-22 | ||
| MOLECULAR PATHOLOGY | 8-22 | ||
| MICROSCOPIC PATHOLOGY | 8-24 | ||
| ANCILLARY TESTS | 8-24 | ||
| DIFFERENTIAL DIAGNOSIS | 8-24 | ||
| SELECTED REFERENCES | 8-24 | ||
| CHAPTER 118. OTHER HEAD AND NECK TUMORS | 8-26 | ||
| TERMINOLOGY | 8-26 | ||
| ETIOLOGY/PATHOGENESIS | 8-26 | ||
| CLINICAL ISSUES | 8-26 | ||
| MOLECULAR PATHOLOGY | 8-27 | ||
| MICROSCOPIC PATHOLOGY | 8-28 | ||
| ANCILLARY TESTS | 8-28 | ||
| DIFFERENTIAL DIAGNOSIS | 8-29 | ||
| DIAGNOSTIC CHECKLIST | 8-29 | ||
| SELECTED REFERENCES | 8-29 | ||
| CHAPTER 119. PAPILLARY THYROID CARCINOMA | 8-32 | ||
| TERMINOLOGY | 8-32 | ||
| ETIOLOGY/PATHOGENESIS | 8-32 | ||
| CLINICAL ISSUES | 8-32 | ||
| MACROSCOPIC FEATURES | 8-32 | ||
| MOLECULAR PATHOLOGY | 8-33 | ||
| MICROSCOPIC PATHOLOGY | 8-34 | ||
| ANCILLARY TESTS | 8-34 | ||
| DIFFERENTIAL DIAGNOSIS | 8-34 | ||
| SELECTED REFERENCES | 8-34 | ||
| CHAPTER 120. FOLLICULAR THYROID CARCINOMA | 8-36 | ||
| TERMINOLOGY | 8-36 | ||
| ETIOLOGY/PATHOGENESIS | 8-36 | ||
| CLINICAL ISSUES | 8-36 | ||
| IMAGE FINDINGS | 8-37 | ||
| MACROSCOPIC FEATURES | 8-37 | ||
| MOLECULAR PATHOLOGY | 8-37 | ||
| MICROSCOPIC PATHOLOGY | 8-38 | ||
| ANCILLARY TESTS | 8-38 | ||
| DIFFERENTIAL DIAGNOSIS | 8-38 | ||
| DIAGNOSTIC CHECKLIST | 8-38 | ||
| SELECTED REFERENCES | 8-38 | ||
| CHAPTER 121. POORLY DIFFERENTIATED THYROID CARCINOMA | 8-40 | ||
| TERMINOLOGY | 8-40 | ||
| ETIOLOGY/PATHOGENESIS | 8-40 | ||
| CLINICAL ISSUES | 8-40 | ||
| MACROSCOPIC FEATURES | 8-40 | ||
| MOLECULAR PATHOLOGY | 8-40 | ||
| MICROSCOPIC PATHOLOGY | 8-41 | ||
| ANCILLARY TESTS | 8-42 | ||
| DIFFERENTIAL DIAGNOSIS | 8-42 | ||
| SELECTED REFERENCES | 8-42 | ||
| CHAPTER 122. UNDIFFERENTIATED THYROID CARCINOMA | 8-44 | ||
| TERMINOLOGY | 8-44 | ||
| ETIOLOGY/PATHOGENESIS | 8-44 | ||
| CLINICAL ISSUES | 8-44 | ||
| MOLECULAR PATHOLOGY | 8-44 | ||
| MICROSCOPIC PATHOLOGY | 8-46 | ||
| ANCILLARY TESTS | 8-46 | ||
| DIFFERENTIAL DIAGNOSIS | 8-46 | ||
| SELECTED REFERENCES | 8-46 | ||
| CHAPTER 123. MEDULLARY THYROID CARCINOMA | 8-48 | ||
| TERMINOLOGY | 8-48 | ||
| ETIOLOGY/PATHOGENESIS | 8-48 | ||
| CLINICAL ISSUES | 8-48 | ||
| MACROSCOPIC FEATURES | 8-49 | ||
| MOLECULAR PATHOLOGY | 8-49 | ||
| MICROSCOPIC PATHOLOGY | 8-50 | ||
| ANCILLARY TESTS | 8-50 | ||
| DIFFERENTIAL DIAGNOSIS | 8-50 | ||
| SELECTED REFERENCES | 8-51 | ||
| CHAPTER 124. ADENOCARCINOMA, LUNG | 8-54 | ||
| TERMINOLOGY | 8-54 | ||
| ETIOLOGY/PATHOGENESIS | 8-54 | ||
| CLINICAL ISSUES | 8-54 | ||
| MACROSCOPIC FEATURES | 8-55 | ||
| MOLECULAR PATHOLOGY | 8-55 | ||
| MICROSCOPIC PATHOLOGY | 8-57 | ||
| ANCILLARY TESTS | 8-57 | ||
| DIFFERENTIAL DIAGNOSIS | 8-58 | ||
| DIAGNOSTIC CHECKLIST | 8-58 | ||
| GRADING | 8-58 | ||
| SELECTED REFERENCES | 8-58 | ||
| CHAPTER 125. SQUAMOUS CELL CARCINOMA, LUNG | 8-62 | ||
| TERMINOLOGY | 8-62 | ||
| ETIOLOGY/PATHOGENESIS | 8-62 | ||
| CLINICAL ISSUES | 8-62 | ||
| MACROSCOPIC FEATURES | 8-63 | ||
| MOLECULAR PATHOLOGY | 8-63 | ||
| MICROSCOPIC PATHOLOGY | 8-64 | ||
| DIFFERENTIAL DIAGNOSIS | 8-64 | ||
| DIAGNOSTIC CHECKLIST | 8-64 | ||
| GRADING | 8-64 | ||
| SELECTED REFERENCES | 8-64 | ||
| CHAPTER 126. SMALL CELL NEUROENDOCRINE CARCINOMA | 8-66 | ||
| TERMINOLOGY | 8-66 | ||
| ETIOLOGY/PATHOGENESIS | 8-66 | ||
| CLINICAL ISSUES | 8-66 | ||
| IMAGE FINDINGS | 8-67 | ||
| MACROSCOPIC FEATURES | 8-67 | ||
| MOLECULAR PATHOLOGY | 8-67 | ||
| MICROSCOPIC PATHOLOGY | 8-68 | ||
| ANCILLARY TESTS | 8-68 | ||
| DIFFERENTIAL DIAGNOSIS | 8-68 | ||
| SELECTED REFERENCES | 8-68 | ||
| CHAPTER 127. MESOTHELIOMA | 8-70 | ||
| TERMINOLOGY | 8-70 | ||
| ETIOLOGY/PATHOGENESIS | 8-70 | ||
| CLINICAL ISSUES | 8-70 | ||
| IMAGE FINDINGS | 8-71 | ||
| MOLECULAR PATHOLOGY | 8-71 | ||
| MICROSCOPIC PATHOLOGY | 8-71 | ||
| ANCILLARY TESTS | 8-71 | ||
| DIFFERENTIAL DIAGNOSIS | 8-71 | ||
| SELECTED REFERENCES | 8-71 | ||
| IMAGE GALLERY | 8-71 | ||
| CHAPTER 128. GASTRIC ADENOCARCINOMA | 8-72 | ||
| TERMINOLOGY | 8-72 | ||
| ETIOLOGY/PATHOGENESIS | 8-72 | ||
| CLINICAL ISSUES | 8-72 | ||
| MACROSCOPIC FEATURES | 8-73 | ||
| MOLECULAR PATHOLOGY | 8-73 | ||
| MICROSCOPIC PATHOLOGY | 8-73 | ||
| ANCILLARY TESTS | 8-74 | ||
| DIFFERENTIAL DIAGNOSIS | 8-74 | ||
| DIAGNOSTIC CHECKLIST | 8-74 | ||
| SELECTED REFERENCES | 8-74 | ||
| CHAPTER 129. COLORECTAL ADENOCARCINOMA AND PRECANCEROUS LESIONS | 8-76 | ||
| TERMINOLOGY | 8-76 | ||
| ETIOLOGY/PATHOGENESIS | 8-76 | ||
| CLINICAL ISSUES | 8-77 | ||
| MACROSCOPIC FEATURES | 8-77 | ||
| MOLECULAR PATHOLOGY | 8-78 | ||
| MICROSCOPIC PATHOLOGY | 8-78 | ||
| ANCILLARY TESTS | 8-79 | ||
| DIFFERENTIAL DIAGNOSIS | 8-79 | ||
| DIAGNOSTIC CHECKLIST | 8-79 | ||
| SELECTED REFERENCES | 8-79 | ||
| CHAPTER 130. GASTROINTESTINAL STROMAL TUMOR | 8-82 | ||
| TERMINOLOGY | 8-82 | ||
| CLINICAL ISSUES | 8-82 | ||
| MACROSCOPIC FEATURES | 8-83 | ||
| MOLECULAR PATHOLOGY | 8-83 | ||
| MICROSCOPIC PATHOLOGY | 8-84 | ||
| ANCILLARY TESTS | 8-85 | ||
| DIFFERENTIAL DIAGNOSIS | 8-85 | ||
| DIAGNOSTIC CHECKLIST | 8-86 | ||
| SELECTED REFERENCES | 8-86 | ||
| CHAPTER 131. HNF1α-INACTIVATED HEPATOCELLULAR ADENOMA | 8-90 | ||
| TERMINOLOGY | 8-90 | ||
| ETIOLOGY/PATHOGENESIS | 8-90 | ||
| CLINICAL ISSUES | 8-90 | ||
| IMAGE FINDINGS | 8-90 | ||
| MACROSCOPIC FEATURES | 8-91 | ||
| MOLECULAR PATHOLOGY | 8-91 | ||
| MICROSCOPIC PATHOLOGY | 8-91 | ||
| ANCILLARY TESTS | 8-91 | ||
| DIFFERENTIAL DIAGNOSIS | 8-92 | ||
| SELECTED REFERENCES | 8-92 | ||
| CHAPTER 132. Î’-CATENIN-ACTIVATED HEPATOCELLULAR ADENOMA | 8-94 | ||
| TERMINOLOGY | 8-94 | ||
| ETIOLOGY/PATHOGENESIS | 8-94 | ||
| CLINICAL ISSUES | 8-94 | ||
| IMAGE FINDINGS | 8-94 | ||
| MACROSCOPIC FEATURES | 8-95 | ||
| MOLECULAR PATHOLOGY | 8-95 | ||
| MICROSCOPIC PATHOLOGY | 8-95 | ||
| ANCILLARY TESTS | 8-95 | ||
| DIFFERENTIAL DIAGNOSIS | 8-96 | ||
| DIAGNOSTIC CHECKLIST | 8-96 | ||
| SELECTED REFERENCES | 8-96 | ||
| CHAPTER 133. INFLAMMATORY HEPATOCELLULAR ADENOMA | 8-98 | ||
| TERMINOLOGY | 8-98 | ||
| ETIOLOGY/PATHOGENESIS | 8-98 | ||
| CLINICAL ISSUES | 8-98 | ||
| IMAGE FINDINGS | 8-98 | ||
| MACROSCOPIC FEATURES | 8-99 | ||
| MOLECULAR PATHOLOGY | 8-99 | ||
| MICROSCOPIC PATHOLOGY | 8-99 | ||
| ANCILLARY TESTS | 8-99 | ||
| DIFFERENTIAL DIAGNOSIS | 8-100 | ||
| DIAGNOSTIC CHECKLIST | 8-100 | ||
| SELECTED REFERENCES | 8-100 | ||
| CHAPTER 134. HEPATOCELLULAR CARCINOMA | 8-104 | ||
| TERMINOLOGY | 8-104 | ||
| ETIOLOGY/PATHOGENESIS | 8-104 | ||
| CLINICAL ISSUES | 8-104 | ||
| MACROSCOPIC FEATURES | 8-105 | ||
| MOLECULAR PATHOLOGY | 8-105 | ||
| MICROSCOPIC PATHOLOGY | 8-106 | ||
| ANCILLARY TESTS | 8-106 | ||
| DIFFERENTIAL DIAGNOSIS | 8-106 | ||
| SELECTED REFERENCES | 8-106 | ||
| CHAPTER 135. PANCREATIC DUCTAL ADENOCARCINOMA | 8-108 | ||
| TERMINOLOGY | 8-108 | ||
| ETIOLOGY/PATHOGENESIS | 8-108 | ||
| CLINICAL ISSUES | 8-108 | ||
| MACROSCOPIC FEATURES | 8-109 | ||
| MOLECULAR PATHOLOGY | 8-109 | ||
| MICROSCOPIC PATHOLOGY | 8-110 | ||
| ANCILLARY TESTS | 8-110 | ||
| DIFFERENTIAL DIAGNOSIS | 8-110 | ||
| SELECTED REFERENCES | 8-110 | ||
| CHAPTER 136. PANCREATIC MUCINOUS CYSTIC NEOPLASM | 8-112 | ||
| TERMINOLOGY | 8-112 | ||
| CLINICAL ISSUES | 8-112 | ||
| MACROSCOPIC FEATURES | 8-112 | ||
| MOLECULAR PATHOLOGY | 8-112 | ||
| MICROSCOPIC PATHOLOGY | 8-113 | ||
| ANCILLARY TESTS | 8-113 | ||
| DIFFERENTIAL DIAGNOSIS | 8-113 | ||
| SELECTED REFERENCES | 8-113 | ||
| MICROSCOPIC FEATURES | 8-113 | ||
| CHAPTER 137. PANCREATIC INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM | 8-114 | ||
| TERMINOLOGY | 8-114 | ||
| CLINICAL ISSUES | 8-114 | ||
| MACROSCOPIC FEATURES | 8-114 | ||
| MOLECULAR PATHOLOGY | 8-114 | ||
| MICROSCOPIC PATHOLOGY | 8-115 | ||
| DIFFERENTIAL DIAGNOSIS | 8-115 | ||
| SELECTED REFERENCES | 8-115 | ||
| MICROSCOPIC FEATURES | 8-115 | ||
| CHAPTER 138. CHOLANGIOCARCINOMA | 8-116 | ||
| TERMINOLOGY | 8-116 | ||
| ETIOLOGY/PATHOGENESIS | 8-116 | ||
| CLINICAL ISSUES | 8-116 | ||
| MACROSCOPIC FEATURES | 8-116 | ||
| MOLECULAR PATHOLOGY | 8-117 | ||
| MICROSCOPIC PATHOLOGY | 8-117 | ||
| ANCILLARY TESTS | 8-117 | ||
| DIFFERENTIAL DIAGNOSIS | 8-117 | ||
| SELECTED REFERENCES | 8-117 | ||
| MICROSCOPIC FEATURES | 8-117 | ||
| CHAPTER 139. TESTICULAR GERM CELL TUMORS | 8-118 | ||
| TERMINOLOGY | 8-118 | ||
| ETIOLOGY/PATHOGENESIS | 8-118 | ||
| TESTICULAR GERM CELL TUMORS IN PREPUBERTAL BOYS | 8-118 | ||
| TESTICULAR GERM CELL TUMORS IN POSTPUBERTAL MALES | 8-119 | ||
| CLINICAL ISSUES | 8-119 | ||
| MOLECULAR PATHOLOGY | 8-120 | ||
| MICROSCOPIC PATHOLOGY | 8-120 | ||
| ANCILLARY TESTS | 8-121 | ||
| SELECTED REFERENCES | 8-121 | ||
| CHAPTER 140. CLEAR CELL RENAL CELL CARCINOMA | 8-124 | ||
| TERMINOLOGY | 8-124 | ||
| ETIOLOGY/PATHOGENESIS | 8-124 | ||
| CLINICAL ISSUES | 8-124 | ||
| MOLECULAR PATHOLOGY | 8-125 | ||
| MICROSCOPIC PATHOLOGY | 8-126 | ||
| ANCILLARY TESTS | 8-126 | ||
| DIFFERENTIAL DIAGNOSIS | 8-126 | ||
| SELECTED REFERENCES | 8-126 | ||
| CHAPTER 141. CHROMOPHOBE RENAL CELL CARCINOMA | 8-128 | ||
| TERMINOLOGY | 8-128 | ||
| ETIOLOGY/PATHOGENESIS | 8-128 | ||
| CLINICAL ISSUES | 8-128 | ||
| MACROSCOPIC FEATURES | 8-128 | ||
| MOLECULAR PATHOLOGY | 8-128 | ||
| MICROSCOPIC PATHOLOGY | 8-129 | ||
| ANCILLARY TESTS | 8-129 | ||
| DIFFERENTIAL DIAGNOSIS | 8-129 | ||
| SELECTED REFERENCES | 8-129 | ||
| IMAGE GALLERY | 8-129 | ||
| CHAPTER 142. PAPILLARY RENAL CELL CARCINOMA | 8-130 | ||
| TERMINOLOGY | 8-130 | ||
| CLINICAL ISSUES | 8-130 | ||
| MOLECULAR PATHOLOGY | 8-130 | ||
| MICROSCOPIC PATHOLOGY | 8-131 | ||
| ANCILLARY TESTS | 8-131 | ||
| DIFFERENTIAL DIAGNOSIS | 8-131 | ||
| SELECTED REFERENCES | 8-131 | ||
| IMAGE GALLERY | 8-131 | ||
| CHAPTER 143. TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA | 8-132 | ||
| TERMINOLOGY | 8-132 | ||
| TRANSLOCATION-ASSOCIATED RCC VARIANTS | 8-132 | ||
| ETIOLOGY/PATHOGENESIS | 8-132 | ||
| CLINICAL ISSUES | 8-133 | ||
| MOLECULAR PATHOLOGY | 8-133 | ||
| MACROSCOPIC PATHOLOGY | 8-134 | ||
| MICROSCOPIC PATHOLOGY | 8-134 | ||
| ANCILLARY TESTS | 8-134 | ||
| SELECTED REFERENCES | 8-134 | ||
| CHAPTER 144. WILMS TUMOR | 8-136 | ||
| TERMINOLOGY | 8-136 | ||
| ETIOLOGY/PATHOGENESIS | 8-136 | ||
| CLINICAL ISSUES | 8-137 | ||
| MACROSCOPIC FEATURES | 8-137 | ||
| MOLECULAR PATHOLOGY | 8-138 | ||
| MICROSCOPIC PATHOLOGY | 8-139 | ||
| ANCILLARY TESTS | 8-139 | ||
| DIFFERENTIAL DIAGNOSIS | 8-139 | ||
| SELECTED REFERENCES | 8-139 | ||
| CHAPTER 145. CLEAR CELL SARCOMA OF KIDNEY | 8-142 | ||
| TERMINOLOGY | 8-142 | ||
| ETIOLOGY/PATHOGENESIS | 8-142 | ||
| CLINICAL ISSUES | 8-142 | ||
| MACROSCOPIC FEATURES | 8-142 | ||
| MOLECULAR PATHOLOGY | 8-142 | ||
| MICROSCOPIC PATHOLOGY | 8-143 | ||
| ANCILLARY TESTS | 8-143 | ||
| DIFFERENTIAL DIAGNOSIS | 8-143 | ||
| SELECTED REFERENCES | 8-143 | ||
| IMAGE GALLERY | 8-143 | ||
| CHAPTER 146. ONCOCYTOMA | 8-144 | ||
| TERMINOLOGY | 8-144 | ||
| ETIOLOGY/PATHOGENESIS | 8-144 | ||
| CLINICAL ISSUES | 8-144 | ||
| MACROSCOPIC FEATURES | 8-144 | ||
| MOLECULAR PATHOLOGY | 8-144 | ||
| MICROSCOPIC PATHOLOGY | 8-144 | ||
| ANCILLARY TESTS | 8-145 | ||
| DIFFERENTIAL DIAGNOSIS | 8-145 | ||
| DIAGNOSTIC CHECKLIST | 8-145 | ||
| SELECTED REFERENCES | 8-145 | ||
| IMAGE GALLERY | 8-145 | ||
| CHAPTER 147. RHABDOID TUMOR OF KIDNEY | 8-146 | ||
| TERMINOLOGY | 8-146 | ||
| ETIOLOGY/PATHOGENESIS | 8-146 | ||
| CLINICAL ISSUES | 8-146 | ||
| MOLECULAR PATHOLOGY | 8-146 | ||
| MICROSCOPIC PATHOLOGY | 8-147 | ||
| ANCILLARY TESTS | 8-147 | ||
| DIFFERENTIAL DIAGNOSIS | 8-147 | ||
| DIAGNOSTIC CHECKLIST | 8-147 | ||
| SELECTED REFERENCES | 8-147 | ||
| IMAGE GALLERY | 8-147 | ||
| CHAPTER 148. UROTHELIAL CARCINOMA | 8-148 | ||
| TERMINOLOGY | 8-148 | ||
| ETIOLOGY/PATHOGENESIS | 8-148 | ||
| CLINICAL ISSUES | 8-148 | ||
| MOLECULAR PATHOLOGY | 8-149 | ||
| MICROSCOPIC PATHOLOGY | 8-151 | ||
| ANCILLARY TESTS | 8-151 | ||
| DIFFERENTIAL DIAGNOSIS | 8-151 | ||
| SELECTED REFERENCES | 8-151 | ||
| CHAPTER 149. PHEOCHROMOCYTOMA/PARAGANGLIOMA | 8-154 | ||
| TERMINOLOGY | 8-154 | ||
| ETIOLOGY/PATHOGENESIS | 8-154 | ||
| CLINICAL ISSUES | 8-155 | ||
| MACROSCOPIC FEATURES | 8-155 | ||
| MOLECULAR PATHOLOGY | 8-156 | ||
| MICROSCOPIC PATHOLOGY | 8-156 | ||
| ANCILLARY TESTS | 8-156 | ||
| DIFFERENTIAL DIAGNOSIS | 8-157 | ||
| SELECTED REFERENCES | 8-157 | ||
| CHAPTER 150. ADRENAL CORTICAL CARCINOMA | 8-160 | ||
| TERMINOLOGY | 8-160 | ||
| ETIOLOGY/PATHOGENESIS | 8-160 | ||
| CLINICAL ISSUES | 8-160 | ||
| IMAGE FINDINGS | 8-161 | ||
| MACROSCOPIC FEATURES | 8-161 | ||
| MOLECULAR PATHOLOGY | 8-161 | ||
| MICROSCOPIC PATHOLOGY | 8-162 | ||
| ANCILLARY TESTS | 8-163 | ||
| DIFFERENTIAL DIAGNOSIS | 8-163 | ||
| STAGING | 8-163 | ||
| SELECTED REFERENCES | 8-163 | ||
| CHAPTER 151. NEUROBLASTOMA | 8-166 | ||
| TERMINOLOGY | 8-166 | ||
| ETIOLOGY/PATHOGENESIS | 8-166 | ||
| CLINICAL ISSUES | 8-166 | ||
| IMAGE FINDINGS | 8-167 | ||
| MACROSCOPIC FEATURES | 8-167 | ||
| MOLECULAR PATHOLOGY | 8-167 | ||
| MICROSCOPIC PATHOLOGY | 8-168 | ||
| ANCILLARY TESTS | 8-169 | ||
| DIFFERENTIAL DIAGNOSIS | 8-169 | ||
| SELECTED REFERENCES | 8-170 | ||
| CHAPTER 152. ADRENAL CORTICAL ADENOMA | 8-174 | ||
| TERMINOLOGY | 8-174 | ||
| ETIOLOGY/PATHOGENESIS | 8-174 | ||
| CLINICAL ISSUES | 8-174 | ||
| IMAGE FINDINGS | 8-175 | ||
| MACROSCOPIC FEATURES | 8-175 | ||
| MOLECULAR PATHOLOGY | 8-175 | ||
| MICROSCOPIC PATHOLOGY | 8-176 | ||
| ANCILLARY TESTS | 8-176 | ||
| DIFFERENTIAL DIAGNOSIS | 8-176 | ||
| SELECTED REFERENCES | 8-176 | ||
| CHAPTER 153. PROSTATIC ADENOCARCINOMA, ACINAR TYPE AND HIGH-GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA | 8-178 | ||
| TERMINOLOGY | 8-178 | ||
| ETIOLOGY/PATHOGENESIS | 8-178 | ||
| CLINICAL ISSUES | 8-178 | ||
| MOLECULAR PATHOLOGY | 8-179 | ||
| MICROSCOPIC PATHOLOGY | 8-180 | ||
| ANCILLARY TESTS | 8-180 | ||
| DIFFERENTIAL DIAGNOSIS | 8-180 | ||
| SELECTED REFERENCES | 8-180 | ||
| CHAPTER 154. ADH AND DCIS (DYSPLASTIC, PREMALIGNANT) | 8-182 | ||
| TERMINOLOGY | 8-182 | ||
| ETIOLOGY/PATHOGENESIS | 8-182 | ||
| CLINICAL ISSUES | 8-182 | ||
| MOLECULAR PATHOLOGY | 8-183 | ||
| MICROSCOPIC PATHOLOGY | 8-184 | ||
| SELECTED REFERENCES | 8-184 | ||
| CHAPTER 155. DUCTAL CARCINOMAS | 8-186 | ||
| TERMINOLOGY | 8-186 | ||
| ETIOLOGY/PATHOGENESIS | 8-186 | ||
| MOLECULAR PATHOLOGY | 8-186 | ||
| MICROSCOPIC PATHOLOGY | 8-188 | ||
| ANCILLARY TESTS | 8-189 | ||
| SELECTED REFERENCES | 8-189 | ||
| CHAPTER 156. LOBULAR CARCINOMA | 8-192 | ||
| TERMINOLOGY | 8-192 | ||
| ETIOLOGY/PATHOGENESIS | 8-192 | ||
| CLINICAL ISSUES | 8-192 | ||
| MOLECULAR PATHOLOGY | 8-193 | ||
| MICROSCOPIC PATHOLOGY | 8-194 | ||
| SELECTED REFERENCES | 8-194 | ||
| CHAPTER 157. MEDULLARY CARCINOMA, BREAST | 8-196 | ||
| TERMINOLOGY | 8-196 | ||
| CLINICAL ISSUES | 8-196 | ||
| MACROSCOPIC FEATURES | 8-196 | ||
| MICROSCOPIC PATHOLOGY | 8-197 | ||
| ANCILLARY TESTS | 8-197 | ||
| DIFFERENTIAL DIAGNOSIS | 8-198 | ||
| SELECTED REFERENCES | 8-198 | ||
| CHAPTER 158. METAPLASTIC BREAST CARCINOMA | 8-200 | ||
| TERMINOLOGY | 8-200 | ||
| CLINICAL ISSUES | 8-200 | ||
| IMAGE FINDINGS | 8-200 | ||
| MACROSCOPIC FEATURES | 8-200 | ||
| MOLECULAR PATHOLOGY | 8-201 | ||
| MICROSCOPIC PATHOLOGY | 8-201 | ||
| ANCILLARY TESTS | 8-202 | ||
| DIFFERENTIAL DIAGNOSIS | 8-202 | ||
| SELECTED REFERENCES | 8-202 | ||
| CHAPTER 159. PHYLLODES TUMORS | 8-204 | ||
| TERMINOLOGY | 8-204 | ||
| ETIOLOGY/PATHOGENESIS | 8-204 | ||
| CLINICAL ISSUES | 8-204 | ||
| IMAGE FINDINGS | 8-205 | ||
| MACROSCOPIC FEATURES | 8-205 | ||
| MOLECULAR PATHOLOGY | 8-205 | ||
| MICROSCOPIC PATHOLOGY | 8-206 | ||
| ANCILLARY TESTS | 8-206 | ||
| DIFFERENTIAL DIAGNOSIS | 8-206 | ||
| SELECTED REFERENCES | 8-206 | ||
| CHAPTER 160. PRENEOPLASTIC CONDITIONS, CERVIX/VULVA/VAGINA | 8-208 | ||
| TERMINOLOGY | 8-208 | ||
| ETIOLOGY/PATHOGENESIS | 8-208 | ||
| CLINICAL ISSUES | 8-208 | ||
| MOLECULAR PATHOLOGY | 8-209 | ||
| MICROSCOPIC PATHOLOGY | 8-210 | ||
| ANCILLARY TESTS | 8-210 | ||
| DIFFERENTIAL DIAGNOSIS | 8-210 | ||
| SELECTED REFERENCES | 8-210 | ||
| CHAPTER 161. SQUAMOUS CELL CARCINOMA, CERVIX/VULVA/VAGINA | 8-212 | ||
| TERMINOLOGY | 8-212 | ||
| ETIOLOGY/PATHOGENESIS | 8-212 | ||
| CLINICAL ISSUES | 8-213 | ||
| MOLECULAR PATHOLOGY | 8-213 | ||
| MICROSCOPIC PATHOLOGY | 8-214 | ||
| ANCILLARY TESTS | 8-214 | ||
| DIFFERENTIAL DIAGNOSIS | 8-214 | ||
| SELECTED REFERENCES | 8-214 | ||
| CHAPTER 162. ADENOCARCINOMA, CERVIX/VULVA/VAGINA | 8-216 | ||
| TERMINOLOGY | 8-216 | ||
| ETIOLOGY/PATHOGENESIS | 8-216 | ||
| CLINICAL ISSUES | 8-217 | ||
| MOLECULAR PATHOLOGY | 8-218 | ||
| MICROSCOPIC PATHOLOGY | 8-218 | ||
| ANCILLARY TESTS | 8-218 | ||
| DIFFERENTIAL DIAGNOSIS | 8-218 | ||
| SELECTED REFERENCES | 8-218 | ||
| CHAPTER 163. ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA | 8-220 | ||
| TERMINOLOGY | 8-220 | ||
| ETIOLOGY/PATHOGENESIS | 8-220 | ||
| CLINICAL ISSUES | 8-220 | ||
| MACROSCOPIC FEATURES | 8-220 | ||
| MOLECULAR PATHOLOGY | 8-220 | ||
| MICROSCOPIC PATHOLOGY | 8-220 | ||
| DIFFERENTIAL DIAGNOSIS | 8-221 | ||
| SELECTED REFERENCES | 8-221 | ||
| IMAGE GALLERY | 8-221 | ||
| CHAPTER 164. UTERINE ENDOMETRIOID CARCINOMA | 8-222 | ||
| TERMINOLOGY | 8-222 | ||
| ETIOLOGY/PATHOGENESIS | 8-222 | ||
| CLINICAL ISSUES | 8-222 | ||
| MACROSCOPIC FEATURES | 8-223 | ||
| MOLECULAR PATHOLOGY | 8-223 | ||
| MICROSCOPIC PATHOLOGY | 8-224 | ||
| ANCILLARY TESTS | 8-224 | ||
| DIFFERENTIAL DIAGNOSIS | 8-224 | ||
| SELECTED REFERENCES | 8-224 | ||
| CHAPTER 165. UTERINE SEROUS CARCINOMA | 8-226 | ||
| TERMINOLOGY | 8-226 | ||
| ETIOLOGY/PATHOGENESIS | 8-226 | ||
| CLINICAL ISSUES | 8-226 | ||
| MOLECULAR PATHOLOGY | 8-226 | ||
| MICROSCOPIC PATHOLOGY | 8-227 | ||
| ANCILLARY TESTS | 8-227 | ||
| DIFFERENTIAL DIAGNOSIS | 8-227 | ||
| SELECTED REFERENCES | 8-227 | ||
| MICROSCPIC FEATURES | 8-227 | ||
| CHAPTER 166. CLEAR CELL CARCINOMA, UTERUS | 8-228 | ||
| TERMINOLOGY | 8-228 | ||
| ETIOLOGY/PATHOGENESIS | 8-228 | ||
| CLINICAL ISSUES | 8-228 | ||
| MACROSCOPIC FEATURES | 8-228 | ||
| MICROSCOPIC PATHOLOGY | 8-228 | ||
| ANCILLARY TESTS | 8-229 | ||
| DIFFERENTIAL DIAGNOSIS | 8-230 | ||
| SELECTED REFERENCES | 8-230 | ||
| CHAPTER 167. UTERINE SARCOMAS | 8-232 | ||
| TERMINOLOGY | 8-232 | ||
| EPIDEMIOLOGY | 8-232 | ||
| MICROSCOPIC FINDINGS | 8-233 | ||
| DIFFERENTIAL DIAGNOSIS | 8-234 | ||
| SELECTED REFERENCES | 8-234 | ||
| CHAPTER 168. SEROUS TUMORS OF OVARY AND FALLOPIAN TUBE | 8-240 | ||
| TERMINOLOGY | 8-240 | ||
| ETIOLOGY/PATHOGENESIS | 8-240 | ||
| CLINICAL ISSUES | 8-240 | ||
| IMAGE FINDINGS | 8-241 | ||
| MACROSCOPIC FEATURES | 8-241 | ||
| MOLECULAR PATHOLOGY | 8-242 | ||
| MICROSCOPIC PATHOLOGY | 8-242 | ||
| ANCILLARY TESTS | 8-243 | ||
| DIFFERENTIAL DIAGNOSIS | 8-243 | ||
| SELECTED REFERENCES | 8-243 | ||
| CHAPTER 169. OTHER SURFACE EPITHELIAL TUMORS OF THE OVARY | 8-246 | ||
| TERMINOLOGY | 8-246 | ||
| ETIOLOGY/PATHOGENESIS | 8-246 | ||
| CLINICAL ISSUES | 8-246 | ||
| MACROSCOPIC FEATURES | 8-248 | ||
| MOLECULAR PATHOLOGY | 8-248 | ||
| MICROSCOPIC PATHOLOGY | 8-249 | ||
| ANCILLARY TESTS | 8-250 | ||
| DIFFERENTIAL DIAGNOSIS | 8-250 | ||
| SELECTED REFERENCES | 8-250 | ||
| CHAPTER 170. SEX CORD-STROMAL TUMORS OF THE OVARY | 8-252 | ||
| TERMINOLOGY | 8-252 | ||
| ETIOLOGY/PATHOGENESIS | 8-252 | ||
| CLINICAL ISSUES | 8-252 | ||
| MACROSCOPIC FEATURES | 8-254 | ||
| MOLECULAR PATHOLOGY | 8-254 | ||
| MICROSCOPIC PATHOLOGY | 8-255 | ||
| ANCILLARY TESTS | 8-256 | ||
| DIFFERENTIAL DIAGNOSIS | 8-256 | ||
| SELECTED REFERENCES | 8-256 | ||
| CHAPTER 171. GERM CELL TUMOR, OVARY | 8-258 | ||
| TERMINOLOGY | 8-258 | ||
| ETIOLOGY/PATHOGENESIS | 8-258 | ||
| CLINICAL ISSUES | 8-258 | ||
| MACROSCOPIC FEATURES | 8-258 | ||
| MOLECULAR PATHOLOGY | 8-258 | ||
| MICROSCOPIC PATHOLOGY | 8-259 | ||
| ANCILLARY TESTS | 8-260 | ||
| DIFFERENTIAL DIAGNOSIS | 8-260 | ||
| SELECTED REFERENCES | 8-260 | ||
| CHAPTER 172. PRENEOPLASTIC CONDITIONS, SKIN | 8-262 | ||
| TERMINOLOGY | 8-262 | ||
| ETIOLOGY/PATHOGENESIS | 8-262 | ||
| CLINICAL ISSUES | 8-262 | ||
| MOLECULAR PATHOLOGY | 8-262 | ||
| MICROSCOPIC PATHOLOGY | 8-263 | ||
| ANCILLARY TESTS | 8-263 | ||
| DIFFERENTIAL DIAGNOSIS | 8-264 | ||
| SELECTED REFERENCES | 8-264 | ||
| CHAPTER 173. MELANOMA | 8-266 | ||
| TERMINOLOGY | 8-266 | ||
| CLINICAL ISSUES | 8-266 | ||
| MOLECULAR PATHOLOGY | 8-266 | ||
| MICROSCOPIC PATHOLOGY | 8-268 | ||
| DIFFERENTIAL DIAGNOSIS | 8-268 | ||
| DIAGNOSTIC CHECKLIST | 8-268 | ||
| SELECTED REFERENCES | 8-268 | ||
| CHAPTER 174. SQUAMOUS CELL CARCINOMA, SKIN | 8-270 | ||
| TERMINOLOGY | 8-270 | ||
| ETIOLOGY/PATHOGENESIS | 8-270 | ||
| CLINICAL ISSUES | 8-270 | ||
| MACROSCOPIC FEATURES | 8-270 | ||
| MOLECULAR PATHOLOGY | 8-270 | ||
| MICROSCOPIC PATHOLOGY | 8-271 | ||
| ANCILLARY TESTS | 8-271 | ||
| DIFFERENTIAL DIAGNOSIS | 8-272 | ||
| DIAGNOSTIC CHECKLIST | 8-272 | ||
| SELECTED REFERENCES | 8-272 | ||
| CHAPTER 175. BASAL CELL CARCINOMA, SKIN | 8-274 | ||
| TERMINOLOGY | 8-274 | ||
| ETIOLOGY/PATHOGENESIS | 8-274 | ||
| CLINICAL ISSUES | 8-274 | ||
| MACROSCOPIC FEATURES | 8-274 | ||
| MOLECULAR PATHOLOGY | 8-275 | ||
| MICROSCOPIC PATHOLOGY | 8-275 | ||
| ANCILLARY TESTS | 8-275 | ||
| DIFFERENTIAL DIAGNOSIS | 8-276 | ||
| DIAGNOSTIC CHECKLIST | 8-276 | ||
| SELECTED REFERENCES | 8-276 | ||
| CHAPTER 176. OTHER SKIN CONDITIONS | 8-278 | ||
| TERMINOLOGY | 8-278 | ||
| ETIOLOGY/PATHOGENESIS | 8-278 | ||
| CLINICAL ISSUES | 8-278 | ||
| MOLECULAR PATHOLOGY | 8-278 | ||
| MICROSCOPIC PATHOLOGY | 8-279 | ||
| SELECTED REFERENCES | 8-279 | ||
| CHAPTER 177. OSTEOSARCOMAS | 8-282 | ||
| TERMINOLOGY | 8-282 | ||
| EPIDEMIOLOGY | 8-282 | ||
| ETIOLOGY/PATHOGENESIS | 8-282 | ||
| CLINICAL IMPLICATIONS | 8-283 | ||
| MOLECULAR PATHOLOGY | 8-284 | ||
| MICROSCOPIC FINDINGS | 8-285 | ||
| ANCILLARY STUDIES | 8-286 | ||
| DIFFERENTIAL DIAGNOSIS | 8-286 | ||
| SELECTED REFERENCES | 8-286 | ||
| CHAPTER 178. OVERVIEW OF MOLECULAR PATHOLOGY OF BONE AND SOFT TISSUE TUMORS | 8-290 | ||
| TERMINOLOGY | 8-290 | ||
| EPIDEMIOLOGY | 8-291 | ||
| ETIOLOGY/PATHOGENESIS | 8-291 | ||
| CLINICAL IMPLICATIONS | 8-291 | ||
| MACROSCOPIC FINDINGS | 8-292 | ||
| DIAGNOSTIC STEPS | 8-292 | ||
| MOLECULAR GENETICS | 8-293 | ||
| SELECTED REFERENCES | 8-293 | ||
| CHAPTER 179. EWING SARCOMA | 8-296 | ||
| TERMINOLOGY | 8-296 | ||
| ETIOLOGY/PATHOGENESIS | 8-296 | ||
| CLINICAL ISSUES | 8-296 | ||
| MOLECULAR PATHOLOGY | 8-297 | ||
| MICROSCOPIC PATHOLOGY | 8-298 | ||
| ANCILLARY TESTS | 8-298 | ||
| DIFFERENTIAL DIAGNOSIS | 8-299 | ||
| SELECTED REFERENCES | 8-299 | ||
| CHAPTER 180. OTHER SMALL ROUND BLUE CELL SARCOMAS | 8-302 | ||
| TERMINOLOGY | 8-302 | ||
| EPIDEMIOLOGY | 8-302 | ||
| ETIOLOGY/PATHOGENESIS | 8-302 | ||
| CLINICAL IMPLICATIONS | 8-303 | ||
| MICROSCOPIC FINDINGS | 8-303 | ||
| MOLECULAR GENETICS | 8-303 | ||
| ANCILLARY STUDIES | 8-304 | ||
| DIFFERENTIAL DIAGNOSIS | 8-304 | ||
| SELECTED REFERENCES | 8-304 | ||
| CHAPTER 181. GIANT CELL TUMOR OF BONE | 8-308 | ||
| TERMINOLOGY | 8-308 | ||
| ETIOLOGY/PATHOGENESIS | 8-308 | ||
| CLINICAL ISSUES | 8-308 | ||
| MOLECULAR PATHOLOGY | 8-309 | ||
| MICROSCOPIC PATHOLOGY | 8-310 | ||
| ANCILLARY TESTS | 8-311 | ||
| DIFFERENTIAL DIAGNOSIS | 8-311 | ||
| SELECTED REFERENCES | 8-311 | ||
| CHAPTER 182. INTERMEDIATE AND MALIGNANT CARTILAGINOUS TUMORS OF BONE | 8-314 | ||
| TERMINOLOGY | 8-314 | ||
| EPIDEMIOLOGY | 8-314 | ||
| ETIOLOGY/PATHOGENESIS | 8-315 | ||
| CLINICAL IMPLICATIONS | 8-315 | ||
| MICROSCOPIC FINDINGS | 8-316 | ||
| MOLECULAR PATHOLOGY | 8-317 | ||
| DIFFERENTIAL DIAGNOSIS | 8-318 | ||
| SELECTED REFERENCES | 8-318 | ||
| CHAPTER 183. INTERMEDIATE AND MALIGNANT MYOFIBROBLASTIC/FIBROBLASTIC TUMORS | 8-324 | ||
| TERMINOLOGY | 8-324 | ||
| CLINICAL IMPLICATIONS | 8-324 | ||
| MICROSCOPIC FINDINGS | 8-325 | ||
| DIFFERENTIAL DIAGNOSIS | 8-327 | ||
| SELECTED REFERENCES | 8-327 | ||
| CHAPTER 184. LIPOSARCOMAS | 8-334 | ||
| TERMINOLOGY | 8-334 | ||
| EPIDEMIOLOGY | 8-334 | ||
| ETIOLOGY/PATHOGENESIS | 8-335 | ||
| CLINICAL IMPLICATIONS | 8-335 | ||
| GENETIC FINDINGS | 8-335 | ||
| MICROSCOPIC FINDINGS | 8-337 | ||
| DIFFERENTIAL DIAGNOSIS | 8-338 | ||
| PATHOLOGIC INTERPRETATION PEARLS | 8-338 | ||
| SELECTED REFERENCES | 8-338 | ||
| CHAPTER 185. MUSCLE SARCOMAS | 8-344 | ||
| TERMINOLOGY | 8-344 | ||
| ETIOLOGY/PATHOGENESIS | 8-344 | ||
| CLINICAL IMPLICATIONS | 8-344 | ||
| MICROSCOPIC FINDINGS | 8-345 | ||
| GENETIC FINDINGS | 8-347 | ||
| DIFFERENTIAL DIAGNOSIS | 8-348 | ||
| SELECTED REFERENCES | 8-348 | ||
| CHAPTER 186. INTERMEDIATE AND MALIGNANT VASCULAR TUMORS | 8-354 | ||
| TERMINOLOGY | 8-354 | ||
| ETIOLOGY/PATHOGENESIS | 8-354 | ||
| CLINICAL IMPLICATIONS | 8-354 | ||
| MICROSCOPIC FINDINGS | 8-355 | ||
| GENETIC FINDINGS | 8-356 | ||
| DIFFERENTIAL DIAGNOSIS | 8-357 | ||
| SELECTED REFERENCES | 8-357 | ||
| CHAPTER 187. MALIGNANT PERIPHERAL NERVE SHEATH TUMOR | 8-362 | ||
| TERMINOLOGY | 8-362 | ||
| ETIOLOGY/PATHOGENESIS | 8-362 | ||
| CLINICAL ISSUES | 8-362 | ||
| MOLECULAR PATHOLOGY | 8-362 | ||
| MICROSCOPIC PATHOLOGY | 8-363 | ||
| ANCILLARY TESTS | 8-364 | ||
| DIFFERENTIAL DIAGNOSIS | 8-364 | ||
| SELECTED REFERENCES | 8-364 | ||
| CHAPTER 188. REPRESENTATIVE GENETIC FINDINGS IN BONE AND SOFT TISSUE TUMORS | 8-368 | ||
| CHAPTER 189. RARE SARCOMAS OF UNCERTAIN DIFFERENTIATION WITH SPECIFIC MOLECULAR ALTERATIONS | 8-372 | ||
| TERMINOLOGY | 8-372 | ||
| EPIDEMIOLOGY | 8-372 | ||
| MICROSCOPIC FINDINGS | 8-373 | ||
| SELECTED REFERENCES | 8-375 | ||
| CHAPTER 190. HIGH-GRADE ASTROCYTOMA | 8-382 | ||
| TERMINOLOGY | 8-382 | ||
| CLINICAL ISSUES | 8-382 | ||
| IMAGE FINDINGS | 8-382 | ||
| MACROSCOPIC FEATURES | 8-383 | ||
| MOLECULAR PATHOLOGY | 8-383 | ||
| MICROSCOPIC PATHOLOGY | 8-384 | ||
| ANCILLARY TESTS | 8-384 | ||
| DIFFERENTIAL DIAGNOSIS | 8-384 | ||
| SELECTED REFERENCES | 8-384 | ||
| CHAPTER 191. LOW-GRADE ASTROCYTOMA | 8-386 | ||
| TERMINOLOGY | 8-386 | ||
| CLINICAL ISSUES | 8-386 | ||
| IMAGE FINDINGS | 8-386 | ||
| MOLECULAR PATHOLOGY | 8-386 | ||
| MICROSCOPIC PATHOLOGY | 8-388 | ||
| ANCILLARY TESTS | 8-388 | ||
| DIFFERENTIAL DIAGNOSIS | 8-388 | ||
| DIAGNOSTIC CHECKLIST | 8-388 | ||
| SELECTED REFERENCES | 8-388 | ||
| CHAPTER 192. PILOCYTIC ASTROCYTOMA | 8-390 | ||
| TERMINOLOGY | 8-390 | ||
| ETIOLOGY/PATHOGENESIS | 8-390 | ||
| CLINICAL ISSUES | 8-390 | ||
| IMAGE FINDINGS | 8-391 | ||
| MACROSCOPIC FEATURES | 8-391 | ||
| MOLECULAR PATHOLOGY | 8-391 | ||
| MICROSCOPIC PATHOLOGY | 8-392 | ||
| ANCILLARY TESTS | 8-392 | ||
| DIFFERENTIAL DIAGNOSIS | 8-392 | ||
| DIAGNOSTIC CHECKLIST | 8-392 | ||
| SELECTED REFERENCES | 8-392 | ||
| CHAPTER 193. OLIGODENDROGLIOMA | 8-394 | ||
| TERMINOLOGY | 8-394 | ||
| CLINICAL ISSUES | 8-394 | ||
| IMAGE FINDINGS | 8-394 | ||
| MACROSCOPIC FEATURES | 8-394 | ||
| MOLECULAR PATHOLOGY | 8-394 | ||
| MICROSCOPIC PATHOLOGY | 8-395 | ||
| ANCILLARY TESTS | 8-395 | ||
| DIFFERENTIAL DIAGNOSIS | 8-395 | ||
| SELECTED REFERENCES | 8-395 | ||
| CHAPTER 194. EPENDYMOMA | 8-398 | ||
| TERMINOLOGY | 8-398 | ||
| CLINICAL ISSUES | 8-398 | ||
| IMAGE FINDINGS | 8-398 | ||
| MICROSCOPIC PATHOLOGY | 8-398 | ||
| ANCILLARY TESTS | 8-399 | ||
| DIFFERENTIAL DIAGNOSIS | 8-399 | ||
| GRADING | 8-399 | ||
| SELECTED REFERENCES | 8-399 | ||
| CHAPTER 195. MEDULLOBLASTOMA | 8-402 | ||
| TERMINOLOGY | 8-402 | ||
| ETIOLOGY/PATHOGENESIS | 8-402 | ||
| CLINICAL ISSUES | 8-402 | ||
| IMAGE FINDINGS | 8-403 | ||
| MICROSCOPIC PATHOLOGY | 8-403 | ||
| ANCILLARY TESTS | 8-403 | ||
| DIFFERENTIAL DIAGNOSIS | 8-404 | ||
| SELECTED REFERENCES | 8-404 | ||
| CHAPTER 196. CHOROID PLEXUS TUMORS | 8-408 | ||
| TERMINOLOGY | 8-408 | ||
| ETIOLOGY/PATHOGENESIS | 8-408 | ||
| CLINICAL ISSUES | 8-408 | ||
| MICROSCOPIC PATHOLOGY | 8-408 | ||
| ANCILLARY TESTS | 8-409 | ||
| DIFFERENTIAL DIAGNOSIS | 8-409 | ||
| GRADING | 8-409 | ||
| SELECTED REFERENCES | 8-409 | ||
| CHAPTER 197. MENINGIOMA | 8-412 | ||
| TERMINOLOGY | 8-412 | ||
| ETIOLOGY/PATHOGENESIS | 8-412 | ||
| CLINICAL ISSUES | 8-412 | ||
| IMAGE FINDINGS | 8-412 | ||
| MOLECULAR PATHOLOGY | 8-413 | ||
| MICROSCOPIC PATHOLOGY | 8-414 | ||
| ANCILLARY TESTS | 8-414 | ||
| DIFFERENTIAL DIAGNOSIS | 8-414 | ||
| DIAGNOSTIC CHECKLIST | 8-414 | ||
| GRADING | 8-414 | ||
| SELECTED REFERENCES | 8-414 | ||
| CHAPTER 198. RETINOBLASTOMA | 8-416 | ||
| TERMINOLOGY | 8-416 | ||
| ETIOLOGY/PATHOGENESIS | 8-416 | ||
| CLINICAL ISSUES | 8-416 | ||
| IMAGE FINDINGS | 8-416 | ||
| MACROSCOPIC FEATURES | 8-417 | ||
| MOLECULAR PATHOLOGY | 8-417 | ||
| MICROSCOPIC PATHOLOGY | 8-417 | ||
| DIFFERENTIAL DIAGNOSIS | 8-417 | ||
| SELECTED REFERENCES | 8-417 | ||
| SECTION 9: Quality Assurance and Regulatory Issues | 9-1 | ||
| CHAPTER 199. FEDERAL AGENCIES AND REGULATION OF LABORATORIES | 9-2 | ||
| TERMINOLOGY | 9-2 | ||
| CMS | 9-2 | ||
| FDA | 9-2 | ||
| SELECTED REFERENCES | 9-3 | ||
| CHAPTER 200. FDA REGULATIONS | 9-4 | ||
| TERMINOLOGY | 9-4 | ||
| FDA REGULATION OF IVDS | 9-4 | ||
| REGULATIONS OF LTDS | 9-8 | ||
| SELECTED REFERENCES | 9-9 | ||
| CHAPTER 201. PROFICIENCY TESTING AND ACCREDITATION | 9-10 | ||
| TERMINOLOGY | 9-10 | ||
| ACCREDITATION | 9-10 | ||
| CAP ACCREDITATION | 9-10 | ||
| PROFICIENCY TESTING | 9-12 | ||
| SELECTED REFERENCES | 9-13 | ||
| INDEX | i |