Menu Expand
Diagnostic Pathology: Kidney Diseases E-Book

Diagnostic Pathology: Kidney Diseases E-Book

Matthew R Lindberg | Anthony Chang

(2015)

Additional Information

Book Details

Abstract

Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of common and rare renal diseases and their variants. Outstanding images—including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations—make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. Written by leading pathologists, this second edition presents an up-to-date, concise presentation of major pathological, clinical, pathophysiological, and genetic information for over 240 diagnoses.

  • High-quality, carefully annotated images highlight critical information, including difficult issues of grading and staging and diagnostic dilemmas not covered in depth in other texts
  • Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index
  • Thoroughly updated content throughout with a particular emphasis on practical information that directly assists in making and supporting a diagnosis
  • Over 25 new chapters with information on major advances in nephropathology/nephrology that have occurred since the first edition, especially in the classification of MPGN/complement-related diseases, lupus nephritis, transplant pathology, and newly recognized immunologic and genetic diseases such as ciliopathies, tubulointerstitial nephritis, and glomerulopathies

Table of Contents

Section Title Page Action Price
Front Cover Cover
Diagnostic Pathology: Kidney Diseases iii
Copyright Page iv
Table of Contents xvi
Dedications v
Contributing Authors vi
Image Contributors ix
Preface xi
Acknowledgments xiii
Sections xv
SECTION 1:\rIntroduction 3
Chapter 1.\rIntroduction to Renal Pathology 4
VALUE OF RENAL BIOPSY 4
INDICATIONS FOR RENAL BIOPSY 4
BIOPSY TECHNIQUE AND SAFETY 4
PROCESSING OF TISSUE 4
SYSTEMATIC APPROACH 5
ISSUES IN INTERPRETATION 5
REPORTING RECOMMENDATIONS 5
DEFINITIONS FOR GLOMERULI 6
DEFINITIONS FOR TUBULES 7
DEFINITIONS FOR INTERSTITIUM 8
DEFINITIONS FOR VESSELS 8
SELECTED REFERENCES 8
Chapter 2.\rNormal Kidney Structure 24
TERMINOLOGY 24
MACROSCOPIC 24
MICROSCOPIC 25
SELECTED REFERENCES 27
Chapter 3.\rNormal Kidney Development 36
TERMINOLOGY 36
STAGES OF KIDNEY DEVELOPMENT 36
MAJOR COMPONENTS OF DEVELOPING\rMETANEPHROS, ORIGIN, AND DERIVATIVES 36
STEPS IN METANEPHRIC KIDNEY\rDEVELOPMENT 37
FINAL POSITION OF KIDNEYS 37
GENES IMPORTANT IN KIDNEY\rDEVELOPMENT 38
CELLULAR PROCESSES IN KIDNEY\rDEVELOPMENT 38
SELECTED REFERENCES 38
SECTION 2:\rGlomerular Diseases 46
Chapter 4.\rMinimal Change Disease 48
TERMINOLOGY 49
ETIOLOGY/PATHOGENESIS 49
CLINICAL ISSUES 49
MACROSCOPIC 50
MICROSCOPIC 50
ANCILLARY TESTS 50
DIFFERENTIAL DIAGNOSIS 51
DIAGNOSTIC CHECKLIST 51
SELECTED REFERENCES 51
Chapter 5.\rDrug-Induced Minimal Change Disease 56
TERMINOLOGY 57
ETIOLOGY/PATHOGENESIS 57
CLINICAL ISSUES 57
MICROSCOPIC 57
ANCILLARY TESTS 57
DIFFERENTIAL DIAGNOSIS 57
DIAGNOSTIC CHECKLIST 57
SELECTED REFERENCES 57
Chapter 6.\rEtiologic Classification of Focal Segmental Glomerulosclerosis 58
Chapter 7.\rHistologic Classification of Focal Segmental Glomerulosclerosis 60
TERMINOLOGY 60
CLASSIFICATION SYSTEMS 60
EPIDEMIOLOGY 60
ETIOLOGY/PATHOGENESIS 61
CLINICAL IMPLICATIONS 61
MACROSCOPIC 61
MICROSCOPIC 61
ANCILLARY TESTS 62
DIFFERENTIAL DIAGNOSIS 62
DIAGNOSTIC CHECKLIST 62
SELECTED REFERENCES 62
Chapter 8.\rFocal Segmental Glomerulosclerosis, Primary 64
TERMINOLOGY 65
ETIOLOGY/PATHOGENESIS 65
CLINICAL ISSUES 65
MICROSCOPIC 65
ANCILLARY TESTS 66
DIFFERENTIAL DIAGNOSIS 66
DIAGNOSTIC CHECKLIST 66
SELECTED REFERENCES 66
Chapter 9.\rFocal Segmental Glomerulosclerosis, Adaptive (Secondary) 72
TERMINOLOGY 73
ETIOLOGY/PATHOGENESIS 73
CLINICAL ISSUES 73
MICROSCOPIC 74
ANCILLARY TESTS 74
DIFFERENTIAL DIAGNOSIS 74
DIAGNOSTIC CHECKLIST 74
SELECTED REFERENCES 74
Chapter 10.\rCollapsing Glomerulopathy 78
TERMINOLOGY 79
ETIOLOGY/PATHOGENESIS 79
CLINICAL ISSUES 79
MICROSCOPIC 79
ANCILLARY TESTS 80
DIFFERENTIAL DIAGNOSIS 80
SELECTED REFERENCES 80
Chapter 11.\rBisphosphonate-Induced Collapsing Glomerulopathy 88
TERMINOLOGY 89
ETIOLOGY/PATHOGENESIS 89
CLINICAL ISSUES 89
MICROSCOPIC 89
ANCILLARY TESTS 89
DIFFERENTIAL DIAGNOSIS 89
DIAGNOSTIC CHECKLIST 89
SELECTED REFERENCES 89
Chapter 12.\rEtiologic Classification of Membranous Glomerulonephritis 90
Chapter 13.\rMembranous Glomerulonephritis, Primary 92
TERMINOLOGY 93
ETIOLOGY/PATHOGENESIS 93
CLINICAL ISSUES 93
MICROSCOPIC 93
ANCILLARY TESTS 94
DIFFERENTIAL DIAGNOSIS 94
DIAGNOSTIC CHECKLIST 94
SELECTED REFERENCES 94
Chapter 14.\rMembranous Glomerulonephritis, Secondary 98
TERMINOLOGY 99
ETIOLOGY/PATHOGENESIS 99
CLINICAL ISSUES 99
MICROSCOPIC 99
ANCILLARY TESTS 99
DIFFERENTIAL DIAGNOSIS 99
DIAGNOSTIC CHECKLIST 99
SELECTED REFERENCES 99
Chapter 15.\rMembranous Glomerulonephritis With Anti-TBM Antibodies 102
TERMINOLOGY 103
ETIOLOGY/PATHOGENESIS 103
CLINICAL ISSUES 103
MICROSCOPIC 103
ANCILLARY TESTS 103
DIFFERENTIAL DIAGNOSIS 103
DIAGNOSTIC CHECKLIST 103
SELECTED REFERENCES 103
Chapter 16.\rClassification of MPGN and Complement-Related Diseases 104
TERMINOLOGY 104
C3 GLOMERULOPATHIES 105
IDIOPATHIC MPGN WITH IMMUNE COMPLEX\rDEPOSITION 105
SELECTED REFERENCES 105
Chapter 17.\rDense Deposit Disease 108
TERMINOLOGY 109
ETIOLOGY/PATHOGENESIS 109
CLINICAL ISSUES 109
MICROSCOPIC 109
ANCILLARY TESTS 110
DIFFERENTIAL DIAGNOSIS 110
DIAGNOSTIC CHECKLIST 110
SELECTED REFERENCES 110
Chapter 18.\rC3 Glomerulonephritis 114
TERMINOLOGY 115
ETIOLOGY/PATHOGENESIS 115
CLINICAL ISSUES 115
MICROSCOPIC 115
ANCILLARY TESTS 116
DIFFERENTIAL DIAGNOSIS 116
DIAGNOSTIC CHECKLIST 116
SELECTED REFERENCES 116
Chapter 19.\rMembranoproliferative Glomerulonephritis With Immune Complexes 120
TERMINOLOGY 121
ETIOLOGY/PATHOGENESIS 121
CLINICAL ISSUES 121
MACROSCOPIC 121
MICROSCOPIC 122
ANCILLARY TESTS 122
DIFFERENTIAL DIAGNOSIS 122
DIAGNOSTIC CHECKLIST 123
SELECTED REFERENCES 123
Chapter 20.\rIgA Nephropathy 128
TERMINOLOGY 129
ETIOLOGY/PATHOGENESIS 129
CLINICAL ISSUES 129
MICROSCOPIC 130
ANCILLARY TESTS 130
DIFFERENTIAL DIAGNOSIS 130
DIAGNOSTIC CHECKLIST 131
GRADING 131
SELECTED REFERENCES 131
Chapter 21.\rHenoch-Schönlein Purpura 142
TERMINOLOGY 143
ETIOLOGY/PATHOGENESIS 143
CLINICAL ISSUES 143
MICROSCOPIC 144
ANCILLARY TESTS 144
DIFFERENTIAL DIAGNOSIS 144
DIAGNOSTIC CHECKLIST 144
SELECTED REFERENCES 144
Chapter 22.\rSystemic Lupus Erythematosus 148
TERMINOLOGY 149
ETIOLOGY/PATHOGENESIS 149
CLINICAL ISSUES 149
MICROSCOPIC 150
ANCILLARY TESTS 151
DIFFERENTIAL DIAGNOSIS 151
DIAGNOSTIC CHECKLIST 151
GRADING 152
SELECTED REFERENCES 152
Chapter 23.\rMixed Connective Tissue Disease 166
TERMINOLOGY 167
ETIOLOGY/PATHOGENESIS 167
CLINICAL ISSUES 167
MICROSCOPIC 167
ANCILLARY TESTS 167
DIFFERENTIAL DIAGNOSIS 167
DIAGNOSTIC CHECKLIST 167
SELECTED REFERENCES 167
Chapter 24.\rRheumatoid Arthritis 168
TERMINOLOGY 169
ETIOLOGY/PATHOGENESIS 169
CLINICAL ISSUES 169
MICROSCOPIC 169
ANCILLARY TESTS 170
DIFFERENTIAL DIAGNOSIS 170
SELECTED REFERENCES 170
Chapter 25.\rMixed Cryoglobulinemic Glomerulonephritis 174
TERMINOLOGY 175
ETIOLOGY/PATHOGENESIS 175
CLINICAL ISSUES 175
MICROSCOPIC 175
ANCILLARY TESTS 176
DIFFERENTIAL DIAGNOSIS 176
DIAGNOSTIC CHECKLIST 176
SELECTED REFERENCES 176
Chapter 26.\rAnti-GBM Glomerulonephritis 180
TERMINOLOGY 181
ETIOLOGY/PATHOGENESIS 181
CLINICAL ISSUES 181
MACROSCOPIC 181
MICROSCOPIC 182
ANCILLARY TESTS 182
DIFFERENTIAL DIAGNOSIS 182
DIAGNOSTIC CHECKLIST 182
SELECTED REFERENCES 182
Chapter 27.\rAtypical Anti-GBM Nephritis 188
TERMINOLOGY 189
ETIOLOGY/PATHOGENESIS 189
CLINICAL ISSUES 189
MICROSCOPIC 189
ANCILLARY TESTS 189
DIFFERENTIAL DIAGNOSIS 189
SELECTED REFERENCES 189
Chapter 28.\rIntroduction to Diseases With Monoclonal Immunoglobulin Deposits 192
ETIOLOGY/PATHOGENESIS 192
APPROACH 192
SELECTED REFERENCES 193
Chapter 29.\rMonoclonal Immunoglobulin Deposition Disease 196
TERMINOLOGY 197
ETIOLOGY/PATHOGENESIS 197
CLINICAL ISSUES 197
MICROSCOPIC 197
ANCILLARY TESTS 197
DIFFERENTIAL DIAGNOSIS 198
DIAGNOSTIC CHECKLIST 198
SELECTED REFERENCES 198
Chapter 30.\rProliferative Glomerulonephritis With Monoclonal IgG Deposits 204
TERMINOLOGY 205
ETIOLOGY/PATHOGENESIS 205
CLINICAL ISSUES 205
MICROSCOPIC 205
ANCILLARY TESTS 205
DIFFERENTIAL DIAGNOSIS 205
SELECTED REFERENCES 205
Chapter 31.\rMembranous Glomerulonephritis With Masked IgG Kappa Deposits 208
TERMINOLOGY 209
ETIOLOGY/PATHOGENESIS 209
CLINICAL ISSUES 209
MICROSCOPIC 209
ANCILLARY TESTS 209
DIFFERENTIAL DIAGNOSIS 209
SELECTED REFERENCES 209
Chapter 32.\rType I Cryoglobulinemic Glomerulonephritis 212
TERMINOLOGY 213
ETIOLOGY/PATHOGENESIS 213
CLINICAL ISSUES 213
MICROSCOPIC 213
ANCILLARY TESTS 213
DIFFERENTIAL DIAGNOSIS 213
DIAGNOSTIC CHECKLIST 213
SELECTED REFERENCES 213
Chapter 33.\rWaldenström Macroglobulinemia 216
TERMINOLOGY 217
ETIOLOGY/PATHOGENESIS 217
CLINICAL ISSUES 217
MICROSCOPIC 217
ANCILLARY TESTS 217
DIFFERENTIAL DIAGNOSIS 217
DIAGNOSTIC CHECKLIST 217
SELECTED REFERENCES 217
Chapter 34.\rLight Chain Cast Nephropathy 218
TERMINOLOGY 219
ETIOLOGY/PATHOGENESIS 219
CLINICAL ISSUES 219
MICROSCOPIC 219
ANCILLARY TESTS 219
DIFFERENTIAL DIAGNOSIS 219
DIAGNOSTIC CHECKLIST 219
SELECTED REFERENCES 219
Chapter 35.\rLight Chain Proximal Tubulopathy With Crystals 224
TERMINOLOGY 225
ETIOLOGY/PATHOGENESIS 225
CLINICAL ISSUES 225
MICROSCOPIC 225
ANCILLARY TESTS 225
DIFFERENTIAL DIAGNOSIS 225
SELECTED REFERENCES 225
Chapter 36.\rProximal Tubulopathy Without Crystals 228
TERMINOLOGY 229
ETIOLOGY/PATHOGENESIS 229
CLINICAL ISSUES 229
MICROSCOPIC 229
ANCILLARY TESTS 229
DIFFERENTIAL DIAGNOSIS 229
SELECTED REFERENCES 229
Chapter 37.\rAmyloidosis Classification 232
TERMINOLOGY 232
EPIDEMIOLOGY 232
ETIOLOGY/PATHOGENESIS 232
CLINICAL IMPLICATIONS 232
MACROSCOPIC 233
MICROSCOPIC 233
ANCILLARY TESTS FOR AMYLOID DETECTION 234
SELECTED REFERENCES 234
Chapter 38.\rAL/AH Amyloidosis 238
TERMINOLOGY 239
ETIOLOGY/PATHOGENESIS 239
CLINICAL ISSUES 239
IMAGING 239
MICROSCOPIC 240
ANCILLARY TESTS 240
DIFFERENTIAL DIAGNOSIS 240
DIAGNOSTIC CHECKLIST 240
SELECTED REFERENCES 240
Chapter 39.\rAA Amyloidosis 244
TERMINOLOGY 245
ETIOLOGY/PATHOGENESIS 245
CLINICAL ISSUES 245
MICROSCOPIC 246
ANCILLARY TESTS 246
DIFFERENTIAL DIAGNOSIS 246
SELECTED REFERENCES 246
Chapter 40.\rALECT2 Amyloidosis 248
TERMINOLOGY 249
ETIOLOGY/PATHOGENESIS 249
CLINICAL ISSUES 249
MICROSCOPIC 249
ANCILLARY TESTS 249
DIFFERENTIAL DIAGNOSIS 249
SELECTED REFERENCES 249
Chapter 41.\rAFib Amyloidosis 250
TERMINOLOGY 251
ETIOLOGY/PATHOGENESIS 251
CLINICAL ISSUES 251
MICROSCOPIC 251
ANCILLARY TESTS 251
DIFFERENTIAL DIAGNOSIS 251
SELECTED REFERENCES 251
Chapter 42.\rAApoAI/II Amyloidosis 252
TERMINOLOGY 253
ETIOLOGY/PATHOGENESIS 253
CLINICAL ISSUES 253
MICROSCOPIC 253
ANCILLARY TESTS 253
DIFFERENTIAL DIAGNOSIS 253
SELECTED REFERENCES 253
Chapter 43.\rATTR Amyloidosis 254
TERMINOLOGY 255
ETIOLOGY/PATHOGENESIS 255
CLINICAL ISSUES 255
MICROSCOPIC 256
ANCILLARY TESTS 256
DIFFERENTIAL DIAGNOSIS 256
DIAGNOSTIC CHECKLIST 256
SELECTED REFERENCES 256
Chapter 44.\rDiseases With Organized Deposits 258
INTRODUCTION 258
CHARACTERIZATION OF ORGANIZED\rDEPOSITS 258
SELECTED REFERENCES 259
Chapter 45.\rFibrillary Glomerulopathy 262
TERMINOLOGY 263
ETIOLOGY/PATHOGENESIS 263
CLINICAL ISSUES 263
MICROSCOPIC 263
ANCILLARY TESTS 263
DIFFERENTIAL DIAGNOSIS 263
SELECTED REFERENCES 263
Chapter 46.\rImmunotactoid Glomerulopathy 266
TERMINOLOGY 267
ETIOLOGY/PATHOGENESIS 267
CLINICAL ISSUES 267
MICROSCOPIC 267
ANCILLARY TESTS 267
DIFFERENTIAL DIAGNOSIS 267
DIAGNOSTIC CHECKLIST 267
SELECTED REFERENCES 267
Chapter 47.\rFibronectin Glomerulopathy 270
TERMINOLOGY 271
ETIOLOGY/PATHOGENESIS 271
CLINICAL ISSUES 271
MICROSCOPIC 271
ANCILLARY TESTS 271
DIFFERENTIAL DIAGNOSIS 272
DIAGNOSTIC CHECKLIST 272
SELECTED REFERENCES 272
Chapter 48.\rDiabetic Nephropathy 274
TERMINOLOGY 275
ETIOLOGY/PATHOGENESIS 275
CLINICAL ISSUES 275
MACROSCOPIC 276
MICROSCOPIC 276
ANCILLARY TESTS 277
DIFFERENTIAL DIAGNOSIS 277
DIAGNOSTIC CHECKLIST 278
SELECTED REFERENCES 278
Chapter 49.\rIdiopathic Nodular Glomerulopathy 284
TERMINOLOGY 285
ETIOLOGY/PATHOGENESIS 285
CLINICAL ISSUES 285
MICROSCOPIC 285
ANCILLARY TESTS 285
DIFFERENTIAL DIAGNOSIS 286
DIAGNOSTIC CHECKLIST 286
SELECTED REFERENCES 286
Chapter 50.\rOverview of Infection-Related Glomerular Disease 290
TERMINOLOGY 290
EPIDEMIOLOGY 290
ETIOLOGY/PATHOGENESIS 290
CLINICAL IMPLICATIONS 291
MACROSCOPIC 291
MICROSCOPIC 291
DIAGNOSIS 291
SELECTED REFERENCES 291
Chapter 51.\rAcute Poststreptococcal Glomerulonephritis 294
TERMINOLOGY 295
ETIOLOGY/PATHOGENESIS 295
CLINICAL ISSUES 295
MACROSCOPIC 295
MICROSCOPIC 295
ANCILLARY TESTS 296
DIFFERENTIAL DIAGNOSIS 296
DIAGNOSTIC CHECKLIST 296
SELECTED REFERENCES 296
Chapter 52.\rAcute Postinfectious Glomerulonephritis, Nonstreptococcal 302
TERMINOLOGY 303
ETIOLOGY/PATHOGENESIS 303
CLINICAL ISSUES 303
MICROSCOPIC 303
ANCILLARY TESTS 304
DIFFERENTIAL DIAGNOSIS 304
DIAGNOSTIC CHECKLIST 304
SELECTED REFERENCES 304
Chapter 53.\rIgA Acute Glomerulonephritis Associated With Staphylococcus aureus 308
TERMINOLOGY 309
ETIOLOGY/PATHOGENESIS 309
CLINICAL ISSUES 309
MICROSCOPIC 309
ANCILLARY TESTS 309
DIFFERENTIAL DIAGNOSIS 309
DIAGNOSTIC CHECKLIST 309
SELECTED REFERENCES 309
Chapter 54.\rGlomerulonephritis of Chronic Infection Including Shunt Nephritis 312
TERMINOLOGY 313
ETIOLOGY/PATHOGENESIS 313
CLINICAL ISSUES 313
MICROSCOPIC 313
ANCILLARY TESTS 313
DIFFERENTIAL DIAGNOSIS 313
SELECTED REFERENCES 313
Chapter 55.\rEndocarditis 314
TERMINOLOGY 315
ETIOLOGY/PATHOGENESIS 315
CLINICAL ISSUES 315
MACROSCOPIC 315
MICROSCOPIC 315
ANCILLARY TESTS 316
DIFFERENTIAL DIAGNOSIS 316
DIAGNOSTIC CHECKLIST 316
SELECTED REFERENCES 316
Chapter 56.\rSyphilis 318
TERMINOLOGY 319
ETIOLOGY/PATHOGENESIS 319
CLINICAL ISSUES 319
MICROSCOPIC 319
ANCILLARY TESTS 319
DIFFERENTIAL DIAGNOSIS 319
DIAGNOSTIC CHECKLIST 319
SELECTED REFERENCES 319
Chapter 57.\rLyme Disease 320
TERMINOLOGY 321
ETIOLOGY/PATHOGENESIS 321
CLINICAL ISSUES 321
MICROSCOPIC 321
ANCILLARY TESTS 321
DIFFERENTIAL DIAGNOSIS 321
SELECTED REFERENCES 321
Chapter 58.\rHepatitis B Virus 322
TERMINOLOGY 323
ETIOLOGY/PATHOGENESIS 323
CLINICAL ISSUES 323
MICROSCOPIC 323
ANCILLARY TESTS 323
DIFFERENTIAL DIAGNOSIS 324
DIAGNOSTIC CHECKLIST 324
SELECTED REFERENCES 324
Chapter 59.\rHepatitis C Virus 326
TERMINOLOGY 327
ETIOLOGY/PATHOGENESIS 327
CLINICAL ISSUES 327
MICROSCOPIC 327
DIFFERENTIAL DIAGNOSIS 327
DIAGNOSTIC CHECKLIST 327
SELECTED REFERENCES 327
Chapter 60.\rHIV-Associated Nephropathy 330
TERMINOLOGY 331
ETIOLOGY/PATHOGENESIS 331
CLINICAL ISSUES 331
IMAGING 331
MACROSCOPIC 331
MICROSCOPIC 331
ANCILLARY TESTS 332
DIFFERENTIAL DIAGNOSIS 332
SELECTED REFERENCES 332
Chapter 61.\rMiscellaneous HIV-Associated Renal Diseases 336
TERMINOLOGY 336
HIV-ASSOCIATED LUPUS-LIKE\rGLOMERULONEPHRITIS 336
IgA NEPHROPATHY 337
HIV IMMUNE COMPLEX KIDNEY DISEASE 337
THROMBOTIC MICROANGIOPATHY 337
OTHER IMMUNE COMPLEX DISEASES 338
TUBULOINTERSTITIAL DISEASE 338
RENAL NEOPLASMS 339
DIAGNOSTIC CHECKLIST 339
SELECTED REFERENCES 339
Chapter 62.\rSchistosomiasis 342
TERMINOLOGY 343
ETIOLOGY/PATHOGENESIS 343
CLINICAL ISSUES 343
MICROSCOPIC 343
ANCILLARY TESTS 343
DIFFERENTIAL DIAGNOSIS 343
SELECTED REFERENCES 343
Chapter 63.\rFilariasis 344
TERMINOLOGY 345
ETIOLOGY/PATHOGENESIS 345
CLINICAL ISSUES 345
MICROSCOPIC 345
ANCILLARY TESTS 345
DIFFERENTIAL DIAGNOSIS 345
SELECTED REFERENCES 345
Chapter 64.\rLeishmaniasis 346
TERMINOLOGY 347
ETIOLOGY/PATHOGENESIS 347
CLINICAL ISSUES 347
MICROSCOPIC 347
ANCILLARY TESTS 347
DIFFERENTIAL DIAGNOSIS 347
DIAGNOSTIC CHECKLIST 347
SELECTED REFERENCES 347
Chapter 65.\rOverview and Classification of Genetic Diseases of the Glomerulus 348
TERMINOLOGY 348
CLASSIFICATION CATEGORIES 348
ETIOLOGY/PATHOGENESIS 349
CLINICAL IMPLICATIONS 349
MICROSCOPIC 349
SELECTED REFERENCES 349
Chapter 66.\rAlport Syndrome 352
TERMINOLOGY 353
ETIOLOGY/PATHOGENESIS 353
CLINICAL ISSUES 353
MICROSCOPIC 354
ANCILLARY TESTS 354
DIFFERENTIAL DIAGNOSIS 355
DIAGNOSTIC CHECKLIST 355
SELECTED REFERENCES 355
Chapter 67.\rThin Basement Membrane Disease 364
TERMINOLOGY 365
ETIOLOGY/PATHOGENESIS 365
CLINICAL ISSUES 365
MICROSCOPIC 365
ANCILLARY TESTS 365
DIFFERENTIAL DIAGNOSIS 365
SELECTED REFERENCES 365
Chapter 68.\rPierson Syndrome 366
TERMINOLOGY 367
ETIOLOGY/PATHOGENESIS 367
CLINICAL ISSUES 367
IMAGING 367
MICROSCOPIC 367
ANCILLARY TESTS 367
DIFFERENTIAL DIAGNOSIS 367
SELECTED REFERENCES 367
Chapter 69.\rCongenital Nephrotic Syndrome of the Finnish Type 370
TERMINOLOGY 371
ETIOLOGY/PATHOGENESIS 371
CLINICAL ISSUES 371
IMAGING 371
MACROSCOPIC 371
MICROSCOPIC 371
ANCILLARY TESTS 372
DIFFERENTIAL DIAGNOSIS 372
DIAGNOSTIC CHECKLIST 372
SELECTED REFERENCES 372
Chapter 70.\rPodocin Deficiency 376
TERMINOLOGY 377
ETIOLOGY/PATHOGENESIS 377
CLINICAL ISSUES 377
MICROSCOPIC 377
ANCILLARY TESTS 377
DIFFERENTIAL DIAGNOSIS 377
DIAGNOSTIC CHECKLIST 377
SELECTED REFERENCES 377
Chapter 71.\rAlpha-Actinin-4 Deficiency 378
TERMINOLOGY 379
ETIOLOGY/PATHOGENESIS 379
CLINICAL ISSUES 379
MICROSCOPIC 379
ANCILLARY TESTS 379
DIFFERENTIAL DIAGNOSIS 379
SELECTED REFERENCES 379
Chapter 72.\rAutosomal Dominant FSGS Due to INF2 Mutations 380
TERMINOLOGY 381
ETIOLOGY/PATHOGENESIS 381
CLINICAL ISSUES 381
MICROSCOPIC 381
ANCILLARY TESTS 381
DIFFERENTIAL DIAGNOSIS 381
DIAGNOSTIC CHECKLIST 381
SELECTED REFERENCES 381
Chapter 73.\rDiffuse Mesangial Sclerosis 382
TERMINOLOGY 383
ETIOLOGY/PATHOGENESIS 383
CLINICAL ISSUES 383
MICROSCOPIC 383
ANCILLARY TESTS 383
DIFFERENTIAL DIAGNOSIS 383
DIAGNOSTIC CHECKLIST 383
SELECTED REFERENCES 383
Chapter 74.\rDenys-Drash Syndrome 386
TERMINOLOGY 387
ETIOLOGY/PATHOGENESIS 387
CLINICAL ISSUES 387
MICROSCOPIC 387
ANCILLARY TESTS 387
DIFFERENTIAL DIAGNOSIS 387
DIAGNOSTIC CHECKLIST 387
SELECTED REFERENCES 387
Chapter 75.\rFrasier Syndrome 392
TERMINOLOGY 393
ETIOLOGY/PATHOGENESIS 393
CLINICAL ISSUES 393
MICROSCOPIC 393
ANCILLARY TESTS 393
DIFFERENTIAL DIAGNOSIS 393
SELECTED REFERENCES 393
Chapter 76.\rAPOL1-Related Glomerular Disease 396
TERMINOLOGY 397
ETIOLOGY/PATHOGENESIS 397
CLINICAL ISSUES 397
MICROSCOPIC 397
DIFFERENTIAL DIAGNOSIS 397
SELECTED REFERENCES 397
Chapter 77.\rLecithin-Cholesterol Acyltransferase Deficiency 400
TERMINOLOGY 401
ETIOLOGY/PATHOGENESIS 401
CLINICAL ISSUES 401
MICROSCOPIC 401
ANCILLARY TESTS 401
DIFFERENTIAL DIAGNOSIS 401
SELECTED REFERENCES 401
Chapter 78.\rAPOE Lipoprotein Glomerulopathy 404
TERMINOLOGY 405
ETIOLOGY/PATHOGENESIS 405
CLINICAL ISSUES 405
MICROSCOPIC 405
ANCILLARY TESTS 405
DIFFERENTIAL DIAGNOSIS 405
SELECTED REFERENCES 405
Chapter 79.\rType III Collagen Glomerulopathy 406
TERMINOLOGY 407
ETIOLOGY/PATHOGENESIS 407
CLINICAL ISSUES 407
MICROSCOPIC 407
ANCILLARY TESTS 408
DIFFERENTIAL DIAGNOSIS 408
DIAGNOSTIC CHECKLIST 408
SELECTED REFERENCES 408
Chapter 80.\rGalloway-Mowat Syndrome 410
TERMINOLOGY 411
ETIOLOGY/PATHOGENESIS 411
CLINICAL ISSUES 411
MACROSCOPIC 411
MICROSCOPIC 411
DIFFERENTIAL DIAGNOSIS 411
DIAGNOSTIC CHECKLIST 411
SELECTED REFERENCES 411
Chapter 81.\rFabry Disease 416
TERMINOLOGY 417
ETIOLOGY/PATHOGENESIS 417
CLINICAL ISSUES 417
MACROSCOPIC 418
MICROSCOPIC 418
ANCILLARY TESTS 418
DIFFERENTIAL DIAGNOSIS 419
DIAGNOSTIC CHECKLIST 419
SELECTED REFERENCES 419
Chapter 82.\rGaucher Glomerulopathy 424
TERMINOLOGY 425
ETIOLOGY/PATHOGENESIS 425
CLINICAL ISSUES 425
MICROSCOPIC 425
ANCILLARY TESTS 425
DIFFERENTIAL DIAGNOSIS 425
SELECTED REFERENCES 425
Chapter 83.\rI-Cell Disease (Mucolipidosis II) 426
TERMINOLOGY 427
ETIOLOGY/PATHOGENESIS 427
CLINICAL ISSUES 427
IMAGING 427
MICROSCOPIC 427
ANCILLARY TESTS 427
DIFFERENTIAL DIAGNOSIS 427
DIAGNOSTIC CHECKLIST 427
SELECTED REFERENCES 427
Chapter 84.\rAlagille Syndrome 430
TERMINOLOGY 431
ETIOLOGY/PATHOGENESIS 431
CLINICAL ISSUES 431
MACROSCOPIC 431
MICROSCOPIC 431
ANCILLARY TESTS 431
DIFFERENTIAL DIAGNOSIS 431
SELECTED REFERENCES 431
Chapter 85.\rGlomerulopathy of Hereditary Multiple Exostoses 432
TERMINOLOGY 433
ETIOLOGY/PATHOGENESIS 433
CLINICAL ISSUES 433
MICROSCOPIC 433
ANCILLARY TESTS 433
DIFFERENTIAL DIAGNOSIS 433
SELECTED REFERENCES 433
Chapter 86.\rType III Hyperlipoproteinemia 434
TERMINOLOGY 435
ETIOLOGY/PATHOGENESIS 435
CLINICAL ISSUES 435
MICROSCOPIC 435
ANCILLARY TESTS 435
DIFFERENTIAL DIAGNOSIS 435
DIAGNOSTIC CHECKLIST 435
SELECTED REFERENCES 435
Chapter 87.\rNail-Patella Syndrome 436
TERMINOLOGY 437
ETIOLOGY/PATHOGENESIS 437
CLINICAL ISSUES 437
MICROSCOPIC 437
ANCILLARY TESTS 437
DIFFERENTIAL DIAGNOSIS 437
DIAGNOSTIC CHECKLIST 437
SELECTED REFERENCES 437
Chapter 88.\rC1q Nephropathy 438
TERMINOLOGY 439
ETIOLOGY/PATHOGENESIS 439
CLINICAL ISSUES 439
MICROSCOPIC 439
ANCILLARY TESTS 440
DIFFERENTIAL DIAGNOSIS 440
DIAGNOSTIC CHECKLIST 440
SELECTED REFERENCES 440
Chapter 89.\rIgM Nephropathy 444
TERMINOLOGY 445
ETIOLOGY/PATHOGENESIS 445
CLINICAL ISSUES 445
MICROSCOPIC 445
ANCILLARY TESTS 445
DIFFERENTIAL DIAGNOSIS 445
DIAGNOSTIC CHECKLIST 445
SELECTED REFERENCES 445
Chapter 90.\rHepatic Glomerulosclerosis and IgA Deposition 446
TERMINOLOGY 447
ETIOLOGY/PATHOGENESIS 447
CLINICAL ISSUES 447
MICROSCOPIC 447
ANCILLARY TESTS 447
DIFFERENTIAL DIAGNOSIS 447
SELECTED REFERENCES 447
Chapter 91.\rChloroquine Toxicity 448
TERMINOLOGY 449
ETIOLOGY/PATHOGENESIS 449
CLINICAL ISSUES 449
MICROSCOPIC 449
ANCILLARY TESTS 449
DIFFERENTIAL DIAGNOSIS 449
DIAGNOSTIC CHECKLIST 449
SELECTED REFERENCES 449
Chapter 92.\rIntravascular Large B-Cell Lymphoma 450
TERMINOLOGY 451
CLINICAL ISSUES 451
MACROSCOPIC 451
MICROSCOPIC 451
ANCILLARY TESTS 451
DIFFERENTIAL DIAGNOSIS 451
SELECTED REFERENCES 451
SECTION 3:\rVascular Diseases 452
Chapter 93.\rOverview and Classification of Systemic Vasculitides 454
TERMINOLOGY 454
CHAPEL HILL CONSENSUS CONFERENCE NOMENCLATURE OF SYSTEMIC\rVASCULITIDES (1994 AND REVISED 2012) 455
OTHER CLASSIFICATION SYSTEMS 456
EPIDEMIOLOGY 456
ETIOLOGY/PATHOGENESIS 456
CLINICAL IMPLICATIONS 456
MACROSCOPIC 457
MICROSCOPIC 457
CONDITIONS THAT MIMIC VASCULITIS 457
SELECTED REFERENCES 457
Chapter 94.\rANCA-Related Glomerulonephritis 464
TERMINOLOGY 465
ETIOLOGY/PATHOGENESIS 465
CLINICAL ISSUES 465
MACROSCOPIC 466
MICROSCOPIC 466
ANCILLARY TESTS 466
DIFFERENTIAL DIAGNOSIS 466
DIAGNOSTIC CHECKLIST 467
SELECTED REFERENCES 467
Chapter 95.\rMicroscopic Polyangiitis 470
TERMINOLOGY 471
ETIOLOGY/PATHOGENESIS 471
CLINICAL ISSUES 471
MACROSCOPIC 472
MICROSCOPIC 472
ANCILLARY TESTS 472
DIFFERENTIAL DIAGNOSIS 472
SELECTED REFERENCES 472
Chapter 96.\rGranulomatosis With Polyangiitis (Wegener) 478
TERMINOLOGY 479
ETIOLOGY/PATHOGENESIS 479
CLINICAL ISSUES 479
IMAGING 480
MACROSCOPIC 480
MICROSCOPIC 480
ANCILLARY TESTS 481
DIFFERENTIAL DIAGNOSIS 481
DIAGNOSTIC CHECKLIST 481
SELECTED REFERENCES 481
Chapter 97.\rEosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) 488
TERMINOLOGY 489
ETIOLOGY/PATHOGENESIS 489
CLINICAL ISSUES 489
MICROSCOPIC 490
ANCILLARY TESTS 490
DIFFERENTIAL DIAGNOSIS 490
DIAGNOSTIC CHECKLIST 491
SELECTED REFERENCES 491
Chapter 98.\rDrug-Induced ANCA Vasculitis 494
TERMINOLOGY 495
ETIOLOGY/PATHOGENESIS 495
CLINICAL ISSUES 495
MICROSCOPIC 495
ANCILLARY TESTS 496
DIFFERENTIAL DIAGNOSIS 496
DIAGNOSTIC CHECKLIST 496
SELECTED REFERENCES 496
Chapter 99.\rPolyarteritis Nodosa 498
TERMINOLOGY 499
ETIOLOGY/PATHOGENESIS 499
CLINICAL ISSUES 499
IMAGING 500
MICROSCOPIC 500
DIFFERENTIAL DIAGNOSIS 500
DIAGNOSTIC CHECKLIST 500
SELECTED REFERENCES 500
Chapter 100.\rKawasaki Disease 504
TERMINOLOGY 505
ETIOLOGY/PATHOGENESIS 505
CLINICAL ISSUES 505
IMAGING 506
MICROSCOPIC 506
DIFFERENTIAL DIAGNOSIS 506
SELECTED REFERENCES 506
Chapter 101.\rGiant Cell Arteritis 508
TERMINOLOGY 509
ETIOLOGY/PATHOGENESIS 509
CLINICAL ISSUES 509
IMAGING 509
MICROSCOPIC 510
DIFFERENTIAL DIAGNOSIS 510
DIAGNOSTIC CHECKLIST 510
SELECTED REFERENCES 510
Chapter 102.\rTakayasu Arteritis 512
TERMINOLOGY 513
ETIOLOGY/PATHOGENESIS 513
CLINICAL ISSUES 513
IMAGING 513
MACROSCOPIC 514
MICROSCOPIC 514
DIFFERENTIAL DIAGNOSIS 514
SELECTED REFERENCES 514
Chapter 103.\rHypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis) 516
TERMINOLOGY 517
ETIOLOGY/PATHOGENESIS 517
CLINICAL ISSUES 517
MICROSCOPIC 517
ANCILLARY TESTS 517
DIFFERENTIAL DIAGNOSIS 517
SELECTED REFERENCES 517
Chapter 104.\rIntroduction to Thrombotic Microangiopathies 518
TERMINOLOGY 518
ETIOLOGY/PATHOGENESIS 518
CLINICAL IMPLICATIONS 518
LABORATORY INVESTIGATIONS 519
MACROSCOPIC 519
MICROSCOPIC 519
DIAGNOSTIC CHECKLIST 520
SELECTED REFERENCES 520
Chapter 105.\rHemolytic Uremic Syndrome, Infection Related 524
TERMINOLOGY 525
ETIOLOGY/PATHOGENESIS 525
CLINICAL ISSUES 525
MICROSCOPIC 526
ANCILLARY TESTS 526
DIFFERENTIAL DIAGNOSIS 526
DIAGNOSTIC CHECKLIST 526
SELECTED REFERENCES 526
Chapter 106.\rThrombotic Microangiopathy, Genetic 528
TERMINOLOGY 529
ETIOLOGY/PATHOGENESIS 529
CLINICAL ISSUES 530
MICROSCOPIC 530
ANCILLARY TESTS 530
DIFFERENTIAL DIAGNOSIS 530
DIAGNOSTIC CHECKLIST 530
SELECTED REFERENCES 530
Chapter 107.\rThrombotic Microangiopathy, Autoimmune 532
TERMINOLOGY 533
ETIOLOGY/PATHOGENESIS 533
CLINICAL ISSUES 534
MICROSCOPIC 534
ANCILLARY TESTS 534
DIFFERENTIAL DIAGNOSIS 534
SELECTED REFERENCES 534
Chapter 108.\rThrombotic Microangiopathy, Drug Induced 536
TERMINOLOGY 537
ETIOLOGY/PATHOGENESIS 537
CLINICAL ISSUES 537
MICROSCOPIC 538
ANCILLARY TESTS 538
DIFFERENTIAL DIAGNOSIS 538
DIAGNOSTIC CHECKLIST 538
SELECTED REFERENCES 538
Chapter 109.\rPostpartum Hemolytic Uremic Syndrome 540
TERMINOLOGY 541
ETIOLOGY/PATHOGENESIS 541
CLINICAL ISSUES 541
MICROSCOPIC 542
ANCILLARY TESTS 542
DIFFERENTIAL DIAGNOSIS 542
SELECTED REFERENCES 542
Chapter 110.\rScleroderma Renal Disease 544
TERMINOLOGY 545
ETIOLOGY/PATHOGENESIS 545
CLINICAL ISSUES 545
MICROSCOPIC 546
ANCILLARY TESTS 546
DIFFERENTIAL DIAGNOSIS 546
DIAGNOSTIC CHECKLIST 546
SELECTED REFERENCES 546
Chapter 111.\rPreeclampsia, Eclampsia, HELLP Syndrome 550
TERMINOLOGY 551
ETIOLOGY/PATHOGENESIS 551
CLINICAL ISSUES 551
MICROSCOPIC 551
ANCILLARY TESTS 551
DIFFERENTIAL DIAGNOSIS 551
DIAGNOSTIC CHECKLIST 551
SELECTED REFERENCES 551
Chapter 112.\rRadiation Nephropathy 552
TERMINOLOGY 553
ETIOLOGY/PATHOGENESIS 553
CLINICAL ISSUES 553
MICROSCOPIC 553
ANCILLARY TESTS 553
DIFFERENTIAL DIAGNOSIS 553
DIAGNOSTIC CHECKLIST 553
SELECTED REFERENCES 553
Chapter 113.\rHereditary Endotheliopathy, Retinopathy, Nephropathy, and Stroke 554
TERMINOLOGY 555
ETIOLOGY/PATHOGENESIS 555
CLINICAL ISSUES 555
IMAGING 555
MICROSCOPIC 555
ANCILLARY TESTS 555
DIFFERENTIAL DIAGNOSIS 555
SELECTED REFERENCES 555
Chapter 114.\rSickle Cell Nephropathy 556
TERMINOLOGY 557
ETIOLOGY/PATHOGENESIS 557
CLINICAL ISSUES 557
MACROSCOPIC 557
MICROSCOPIC 557
ANCILLARY TESTS 557
DIFFERENTIAL DIAGNOSIS 557
SELECTED REFERENCES 557
Chapter 115.\rHypertensive Renovascular Disease 560
TERMINOLOGY 561
ETIOLOGY/PATHOGENESIS 561
CLINICAL ISSUES 561
MACROSCOPIC 561
MICROSCOPIC 562
ANCILLARY TESTS 562
DIFFERENTIAL DIAGNOSIS 562
SELECTED REFERENCES 563
Chapter 116.\rRenal Artery Stenosis 568
TERMINOLOGY 569
ETIOLOGY/PATHOGENESIS 569
CLINICAL ISSUES 569
IMAGING 569
MACROSCOPIC 569
MICROSCOPIC 570
ANCILLARY TESTS 570
DIFFERENTIAL DIAGNOSIS 570
DIAGNOSTIC CHECKLIST 571
SELECTED REFERENCES 571
Chapter 117.\rFibromuscular Dysplasia 574
TERMINOLOGY 575
ETIOLOGY/PATHOGENESIS 575
CLINICAL ISSUES 575
IMAGING 575
MACROSCOPIC 575
MICROSCOPIC 575
DIFFERENTIAL DIAGNOSIS 576
DIAGNOSTIC CHECKLIST 576
SELECTED REFERENCES 576
Chapter 118.\rNeurofibromatosis 580
TERMINOLOGY 581
ETIOLOGY/PATHOGENESIS 581
CLINICAL ISSUES 581
IMAGING 581
MACROSCOPIC 581
MICROSCOPIC 581
DIFFERENTIAL DIAGNOSIS 581
DIAGNOSTIC CHECKLIST 581
SELECTED REFERENCES 581
Chapter 119.\rRenal Vein Thrombosis 584
TERMINOLOGY 585
ETIOLOGY/PATHOGENESIS 585
CLINICAL ISSUES 585
MICROSCOPIC 585
ANCILLARY TESTS 585
DIFFERENTIAL DIAGNOSIS 585
DIAGNOSTIC CHECKLIST 585
SELECTED REFERENCES 585
Chapter 120.\rRenal Artery Thrombosis 586
TERMINOLOGY 587
ETIOLOGY/PATHOGENESIS 587
CLINICAL ISSUES 587
IMAGING 587
MACROSCOPIC 587
MICROSCOPIC 587
DIFFERENTIAL DIAGNOSIS 587
SELECTED REFERENCES 587
Chapter 121.\rAtheromatous Emboli 588
TERMINOLOGY 589
ETIOLOGY/PATHOGENESIS 589
CLINICAL ISSUES 589
MACROSCOPIC 589
MICROSCOPIC 589
ANCILLARY TESTS 589
DIFFERENTIAL DIAGNOSIS 589
SELECTED REFERENCES 589
SECTION 4:\rTubulointerstitial Diseases 590
Chapter 122.\rOverview and Classification of Tubulointerstitial Diseases 592
TERMINOLOGY 592
APPROACH TO DIAGNOSIS OF\rTUBULOINTERSTITIAL DISEASES 592
SELECTED REFERENCES 592
Chapter 123.\rDifferential Diagnosis of Acute Interstitial Nephritis 594
ETIOLOGY/PATHOGENESIS 595
CLINICAL ISSUES 595
MICROSCOPIC 595
DIFFERENTIAL DIAGNOSIS 595
SELECTED REFERENCES 595
Chapter 124.\rAcute Tubular Injury 600
TERMINOLOGY 601
ETIOLOGY/PATHOGENESIS 601
CLINICAL ISSUES 601
MACROSCOPIC 601
MICROSCOPIC 601
ANCILLARY TESTS 602
DIFFERENTIAL DIAGNOSIS 602
DIAGNOSTIC CHECKLIST 602
SELECTED REFERENCES 602
Chapter 125.\rRenal Cortical Necrosis 606
TERMINOLOGY 607
ETIOLOGY/PATHOGENESIS 607
CLINICAL ISSUES 607
IMAGING 607
MACROSCOPIC 607
MICROSCOPIC 607
DIFFERENTIAL DIAGNOSIS 607
DIAGNOSTIC CHECKLIST 607
SELECTED REFERENCES 607
Chapter 126.\rBile Cast Nephropathy 608
TERMINOLOGY 609
ETIOLOGY/PATHOGENESIS 609
CLINICAL ISSUES 609
MACROSCOPIC 609
MICROSCOPIC 609
DIFFERENTIAL DIAGNOSIS 609
DIAGNOSTIC CHECKLIST 609
SELECTED REFERENCES 609
Chapter 127.\rDrug-Induced Acute Interstitial Nephritis 612
TERMINOLOGY 613
ETIOLOGY/PATHOGENESIS 613
CLINICAL ISSUES 613
IMAGING 614
MACROSCOPIC 614
MICROSCOPIC 614
ANCILLARY TESTS 614
DIFFERENTIAL DIAGNOSIS 614
DIAGNOSTIC CHECKLIST 615
SELECTED REFERENCES 615
Chapter 128.\rPapillary Necrosis 618
TERMINOLOGY 619
ETIOLOGY/PATHOGENESIS 619
CLINICAL ISSUES 619
IMAGING 619
MACROSCOPIC 619
MICROSCOPIC 619
ANCILLARY TESTS 620
DIFFERENTIAL DIAGNOSIS 620
DIAGNOSTIC CHECKLIST 620
SELECTED REFERENCES 620
Chapter 129.\rMyoglobinuria/Rhabdomyolysis/Hemoglobinuria 622
TERMINOLOGY 623
ETIOLOGY/PATHOGENESIS 623
CLINICAL ISSUES 623
MICROSCOPIC 623
ANCILLARY TESTS 623
DIFFERENTIAL DIAGNOSIS 623
SELECTED REFERENCES 623
Chapter 130.\rCisplatin Nephrotoxicity 624
TERMINOLOGY 625
ETIOLOGY/PATHOGENESIS 625
CLINICAL ISSUES 625
MACROSCOPIC 625
MICROSCOPIC 625
ANCILLARY TESTS 625
DIFFERENTIAL DIAGNOSIS 625
DIAGNOSTIC CHECKLIST 625
SELECTED REFERENCES 625
Chapter 131.\rOsmotic Tubulopathy 626
TERMINOLOGY 627
ETIOLOGY/PATHOGENESIS 627
CLINICAL ISSUES 627
MACROSCOPIC 627
MICROSCOPIC 627
ANCILLARY TESTS 627
DIFFERENTIAL DIAGNOSIS 628
DIAGNOSTIC CHECKLIST 628
SELECTED REFERENCES 628
Chapter 132.\rAntiviral Drug Nephrotoxicity 630
TERMINOLOGY 631
ETIOLOGY/PATHOGENESIS 631
CLINICAL ISSUES 631
MICROSCOPIC 631
ANCILLARY TESTS 632
DIFFERENTIAL DIAGNOSIS 632
DIAGNOSTIC CHECKLIST 632
SELECTED REFERENCES 632
Chapter 133.\rAcute Phosphate Nephropathy 636
TERMINOLOGY 637
ETIOLOGY/PATHOGENESIS 637
CLINICAL ISSUES 637
MICROSCOPIC 637
ANCILLARY TESTS 637
DIFFERENTIAL DIAGNOSIS 637
SELECTED REFERENCES 637
Chapter 134.\rLithium-Induced Renal Disease 638
TERMINOLOGY 639
ETIOLOGY/PATHOGENESIS 639
CLINICAL ISSUES 639
MACROSCOPIC 639
MICROSCOPIC 639
ANCILLARY TESTS 639
DIFFERENTIAL DIAGNOSIS 639
DIAGNOSTIC CHECKLIST 639
SELECTED REFERENCES 639
Chapter 135.\rCalcineurin Inhibitor Toxicity 642
TERMINOLOGY 643
ETIOLOGY/PATHOGENESIS 643
CLINICAL ISSUES 643
MICROSCOPIC 643
DIFFERENTIAL DIAGNOSIS 644
DIAGNOSTIC CHECKLIST 644
SELECTED REFERENCES 644
Chapter 136.\rmTOR Inhibitor Toxicity 648
TERMINOLOGY 649
ETIOLOGY/PATHOGENESIS 649
CLINICAL ISSUES 649
MICROSCOPIC 649
DIFFERENTIAL DIAGNOSIS 649
SELECTED REFERENCES 649
Chapter 137.\rWarfarin Nephropathy 650
TERMINOLOGY 651
ETIOLOGY/PATHOGENESIS 651
CLINICAL ISSUES 651
MICROSCOPIC 651
DIFFERENTIAL DIAGNOSIS 651
SELECTED REFERENCES 651
Chapter 138.\rSepticemia/Shock 652
TERMINOLOGY 653
ETIOLOGY/PATHOGENESIS 653
CLINICAL ISSUES 653
MICROSCOPIC 653
ANCILLARY TESTS 653
DIFFERENTIAL DIAGNOSIS 653
DIAGNOSTIC CHECKLIST 653
SELECTED REFERENCES 653
Chapter 139.\rLead and Other Heavy Metal Toxins 656
TERMINOLOGY 657
ETIOLOGY/PATHOGENESIS 657
CLINICAL ISSUES 657
MACROSCOPIC 657
MICROSCOPIC 657
ANCILLARY TESTS 658
DIFFERENTIAL DIAGNOSIS 658
DIAGNOSTIC CHECKLIST 658
SELECTED REFERENCES 658
Chapter 140.\rAristolochic Acid Nephropathy 660
TERMINOLOGY 661
ETIOLOGY/PATHOGENESIS 661
CLINICAL ISSUES 661
MACROSCOPIC 661
MICROSCOPIC 661
ANCILLARY TESTS 661
DIFFERENTIAL DIAGNOSIS 661
DIAGNOSTIC CHECKLIST 661
SELECTED REFERENCES 661
Chapter 141.\rBalkan Endemic Nephropathy 662
TERMINOLOGY 663
ETIOLOGY/PATHOGENESIS 663
CLINICAL ISSUES 663
MACROSCOPIC 663
MICROSCOPIC 663
DIFFERENTIAL DIAGNOSIS 663
DIAGNOSTIC CHECKLIST 663
SELECTED REFERENCES 663
Chapter 142.\rEthylene Glycol Toxicity 664
TERMINOLOGY 665
ETIOLOGY/PATHOGENESIS 665
CLINICAL ISSUES 665
MACROSCOPIC 665
MICROSCOPIC 665
ANCILLARY TESTS 665
DIFFERENTIAL DIAGNOSIS 665
DIAGNOSTIC CHECKLIST 665
SELECTED REFERENCES 665
Chapter 143.\rArgyria 666
TERMINOLOGY 667
ETIOLOGY/PATHOGENESIS 667
CLINICAL ISSUES 667
MACROSCOPIC 667
MICROSCOPIC 667
ANCILLARY TESTS 667
DIFFERENTIAL DIAGNOSIS 667
DIAGNOSTIC CHECKLIST 667
SELECTED REFERENCES 667
Chapter 144.\rTubulointerstitial Nephritis With Uveitis 668
TERMINOLOGY 669
ETIOLOGY/PATHOGENESIS 669
CLINICAL ISSUES 669
MICROSCOPIC 669
ANCILLARY TESTS 669
DIFFERENTIAL DIAGNOSIS 669
DIAGNOSTIC CHECKLIST 669
SELECTED REFERENCES 669
Chapter 145.\rSjögren Syndrome 672
TERMINOLOGY 673
ETIOLOGY/PATHOGENESIS 673
CLINICAL ISSUES 673
MICROSCOPIC 673
ANCILLARY TESTS 673
DIFFERENTIAL DIAGNOSIS 673
DIAGNOSTIC CHECKLIST 673
SELECTED REFERENCES 673
Chapter 146.\rIgG4-Related Disease 676
TERMINOLOGY 677
ETIOLOGY/PATHOGENESIS 677
CLINICAL ISSUES 677
IMAGING 677
MICROSCOPIC 678
ANCILLARY TESTS 678
DIFFERENTIAL DIAGNOSIS 678
DIAGNOSTIC CHECKLIST 679
SELECTED REFERENCES 679
Chapter 147.\rIdiopathic Hypocomplementemic Tubulointerstitial Nephritis 686
TERMINOLOGY 687
ETIOLOGY/PATHOGENESIS 687
CLINICAL ISSUES 687
IMAGING 687
MICROSCOPIC 687
ANCILLARY TESTS 687
DIFFERENTIAL DIAGNOSIS 687
SELECTED REFERENCES 687
Chapter 148.\rAnti-Tubular Basement Membrane Disease 688
TERMINOLOGY 689
ETIOLOGY/PATHOGENESIS 689
CLINICAL ISSUES 689
MICROSCOPIC 689
ANCILLARY TESTS 689
DIFFERENTIAL DIAGNOSIS 689
DIAGNOSTIC CHECKLIST 689
SELECTED REFERENCES 689
Chapter 149.\rAnti-Brush Border Autoantibody Tubulointerstitial Nephritis 690
TERMINOLOGY 691
ETIOLOGY/PATHOGENESIS 691
CLINICAL ISSUES 691
MICROSCOPIC 691
ANCILLARY TESTS 691
DIFFERENTIAL DIAGNOSIS 691
SELECTED REFERENCES 691
Chapter 150.\rSarcoidosis 692
TERMINOLOGY 693
ETIOLOGY/PATHOGENESIS 693
CLINICAL ISSUES 693
IMAGING 693
MICROSCOPIC 693
ANCILLARY TESTS 693
DIFFERENTIAL DIAGNOSIS 693
DIAGNOSTIC CHECKLIST 693
SELECTED REFERENCES 693
Chapter 151.\rGiant Cell Tubulitis With TBM Deposits 696
TERMINOLOGY 697
ETIOLOGY/PATHOGENESIS 697
CLINICAL ISSUES 697
MICROSCOPIC 697
ANCILLARY TESTS 697
DIFFERENTIAL DIAGNOSIS 697
SELECTED REFERENCES 697
Chapter 152.\rMucin-1-Related Kidney Disease 698
TERMINOLOGY 699
ETIOLOGY/PATHOGENESIS 699
CLINICAL ISSUES 699
IMAGING 699
MICROSCOPIC 699
ANCILLARY TESTS 699
DIFFERENTIAL DIAGNOSIS 699
DIAGNOSTIC CHECKLIST 699
SELECTED REFERENCES 699
Chapter 153.\rUromodulin-Related Kidney Disease 700
TERMINOLOGY 701
ETIOLOGY/PATHOGENESIS 701
CLINICAL ISSUES 701
MACROSCOPIC 701
MICROSCOPIC 701
DIFFERENTIAL DIAGNOSIS 701
DIAGNOSTIC CHECKLIST 701
SELECTED REFERENCES 701
Chapter 154.\rRenin Mutation With Tubulointerstitial Nephritis 702
TERMINOLOGY 703
ETIOLOGY/PATHOGENESIS 703
CLINICAL ISSUES 703
MICROSCOPIC 703
ANCILLARY TESTS 703
DIFFERENTIAL DIAGNOSIS 703
SELECTED REFERENCES 703
Chapter 155.\rKidney Disease Due to Mutations in HNF1B 704
TERMINOLOGY 705
ETIOLOGY/PATHOGENESIS 705
CLINICAL ISSUES 705
MACROSCOPIC 705
MICROSCOPIC 705
DIFFERENTIAL DIAGNOSIS 705
DIAGNOSTIC CHECKLIST 705
SELECTED REFERENCES 705
Chapter 156.\rPrimary Hyperoxaluria 706
TERMINOLOGY 707
ETIOLOGY/PATHOGENESIS 707
CLINICAL ISSUES 707
MACROSCOPIC 707
MICROSCOPIC 707
DIFFERENTIAL DIAGNOSIS 707
DIAGNOSTIC CHECKLIST 707
SELECTED REFERENCES 707
Chapter 157.\r2,8-Dihydroxyadeninuria 708
TERMINOLOGY 709
ETIOLOGY/PATHOGENESIS 709
CLINICAL ISSUES 709
MICROSCOPIC 710
DIFFERENTIAL DIAGNOSIS 710
DIAGNOSTIC CHECKLIST 710
SELECTED REFERENCES 710
Chapter 158.\rCystinosis 712
TERMINOLOGY 713
ETIOLOGY/PATHOGENESIS 713
CLINICAL ISSUES 713
MICROSCOPIC 713
DIFFERENTIAL DIAGNOSIS 713
DIAGNOSTIC CHECKLIST 713
SELECTED REFERENCES 713
Chapter 159.\rUric Acid Nephropathy/Gout 714
TERMINOLOGY 715
ETIOLOGY/PATHOGENESIS 715
CLINICAL ISSUES 715
MACROSCOPIC 716
MICROSCOPIC 716
DIFFERENTIAL DIAGNOSIS 716
DIAGNOSTIC CHECKLIST 716
SELECTED REFERENCES 716
Chapter 160.\rBartter Syndrome 718
TERMINOLOGY 719
ETIOLOGY/PATHOGENESIS 719
CLINICAL ISSUES 719
MICROSCOPIC 719
DIFFERENTIAL DIAGNOSIS 719
DIAGNOSTIC CHECKLIST 719
SELECTED REFERENCES 719
Chapter 161.\rDent Disease 720
TERMINOLOGY 721
ETIOLOGY/PATHOGENESIS 721
CLINICAL ISSUES 721
MICROSCOPIC 721
ANCILLARY TESTS 721
DIFFERENTIAL DIAGNOSIS 721
DIAGNOSTIC CHECKLIST 721
SELECTED REFERENCES 721
Chapter 162.\rOculocerebrorenal Syndrome of Lowe 722
TERMINOLOGY 723
ETIOLOGY/PATHOGENESIS 723
CLINICAL ISSUES 723
IMAGING 723
MICROSCOPIC 723
ANCILLARY TESTS 723
DIFFERENTIAL DIAGNOSIS 723
SELECTED REFERENCES 723
Chapter 163.\rMethylmalonic Acidemia 726
TERMINOLOGY 727
ETIOLOGY/PATHOGENESIS 727
CLINICAL ISSUES 727
MICROSCOPIC 727
DIFFERENTIAL DIAGNOSIS 727
SELECTED REFERENCES 727
Chapter 164.\rSystemic Karyomegaly 728
TERMINOLOGY 729
ETIOLOGY/PATHOGENESIS 729
CLINICAL ISSUES 729
MICROSCOPIC 729
ANCILLARY TESTS 729
DIFFERENTIAL DIAGNOSIS 729
DIAGNOSTIC CHECKLIST 729
SELECTED REFERENCES 729
Chapter 165.\rMitochondriopathies 730
TERMINOLOGY 731
ETIOLOGY/PATHOGENESIS 731
CLINICAL ISSUES 731
MICROSCOPIC 731
ANCILLARY TESTS 731
DIFFERENTIAL DIAGNOSIS 731
SELECTED REFERENCES 731
Chapter 166.\rNephrocalcinosis 734
TERMINOLOGY 735
ETIOLOGY/PATHOGENESIS 735
CLINICAL ISSUES 735
IMAGING 735
MICROSCOPIC 735
ANCILLARY TESTS 735
DIFFERENTIAL DIAGNOSIS 735
DIAGNOSTIC CHECKLIST 735
SELECTED REFERENCES 735
Chapter 167.\rSecondary Oxalosis 736
TERMINOLOGY 737
ETIOLOGY/PATHOGENESIS 737
CLINICAL ISSUES 737
MICROSCOPIC 737
DIFFERENTIAL DIAGNOSIS 737
SELECTED REFERENCES 737
Chapter 168.\rMesoamerican Nephropathy 738
TERMINOLOGY 739
ETIOLOGY/PATHOGENESIS 739
CLINICAL ISSUES 739
MICROSCOPIC 739
ANCILLARY TESTS 739
DIFFERENTIAL DIAGNOSIS 739
SELECTED REFERENCES 739
Chapter 169.\rExtramedullary Hematopoiesis 740
TERMINOLOGY 741
ETIOLOGY/PATHOGENESIS 741
CLINICAL ISSUES 741
MICROSCOPIC 741
ANCILLARY TESTS 741
DIFFERENTIAL DIAGNOSIS 741
SELECTED REFERENCES 741
SECTION 5:\rInfections of the Kidney 745
Chapter 170.\rAcute Pyelonephritis 746
TERMINOLOGY 747
ETIOLOGY/PATHOGENESIS 747
CLINICAL ISSUES 747
IMAGING 748
MACROSCOPIC 748
MICROSCOPIC 748
ANCILLARY TESTS 748
DIFFERENTIAL DIAGNOSIS 748
DIAGNOSTIC CHECKLIST 749
SELECTED REFERENCES 749
Chapter 171.\rChronic Pyelonephritis 754
TERMINOLOGY 755
ETIOLOGY/PATHOGENESIS 755
CLINICAL ISSUES 755
IMAGING 755
MACROSCOPIC 755
MICROSCOPIC 755
ANCILLARY TESTS 755
DIFFERENTIAL DIAGNOSIS 755
DIAGNOSTIC CHECKLIST 755
SELECTED REFERENCES 755
Chapter 172.\rXanthogranulomatous Pyelonephritis 758
TERMINOLOGY 759
ETIOLOGY/PATHOGENESIS 759
CLINICAL ISSUES 759
IMAGING 759
MACROSCOPIC 759
MICROSCOPIC 759
DIFFERENTIAL DIAGNOSIS 759
DIAGNOSTIC CHECKLIST 759
SELECTED REFERENCES 759
Chapter 173.\rMalakoplakia 762
TERMINOLOGY 763
ETIOLOGY/PATHOGENESIS 763
CLINICAL ISSUES 763
MACROSCOPIC 763
MICROSCOPIC 763
ANCILLARY TESTS 763
DIFFERENTIAL DIAGNOSIS 763
DIAGNOSTIC CHECKLIST 763
SELECTED REFERENCES 763
Chapter 174.\rMegalocytic Interstitial Nephritis 766
TERMINOLOGY 767
ETIOLOGY/PATHOGENESIS 767
CLINICAL ISSUES 767
IMAGING 767
MACROSCOPIC 767
MICROSCOPIC 767
ANCILLARY TESTS 767
DIFFERENTIAL DIAGNOSIS 767
SELECTED REFERENCES 767
Chapter 175.\rTuberculosis 768
TERMINOLOGY 769
ETIOLOGY/PATHOGENESIS 769
CLINICAL ISSUES 769
IMAGING 769
MACROSCOPIC 769
MICROSCOPIC 769
ANCILLARY TESTS 769
DIFFERENTIAL DIAGNOSIS 769
SELECTED REFERENCES 769
Chapter 176.\rBCG Granulomatous Interstitial Nephritis 770
TERMINOLOGY 771
ETIOLOGY/PATHOGENESIS 771
CLINICAL ISSUES 771
MACROSCOPIC 771
MICROSCOPIC 771
ANCILLARY TESTS 771
DIFFERENTIAL DIAGNOSIS 771
SELECTED REFERENCES 771
Chapter 177.\rLeprosy 772
TERMINOLOGY 773
ETIOLOGY/PATHOGENESIS 773
CLINICAL ISSUES 773
MICROSCOPIC 773
ANCILLARY TESTS 773
DIFFERENTIAL DIAGNOSIS 773
SELECTED REFERENCES 773
Chapter 178.\rNocardiosis 774
TERMINOLOGY 775
ETIOLOGY/PATHOGENESIS 775
CLINICAL ISSUES 775
IMAGING 775
MICROSCOPIC 775
ANCILLARY TESTS 775
DIFFERENTIAL DIAGNOSIS 775
SELECTED REFERENCES 775
Chapter 179.\rLeptospirosis 776
TERMINOLOGY 777
ETIOLOGY/PATHOGENESIS 777
CLINICAL ISSUES 777
MACROSCOPIC 777
MICROSCOPIC 777
ANCILLARY TESTS 777
DIFFERENTIAL DIAGNOSIS 777
DIAGNOSTIC CHECKLIST 777
SELECTED REFERENCES 777
Chapter 180.\rMucormycosis 778
TERMINOLOGY 779
ETIOLOGY/PATHOGENESIS 779
CLINICAL ISSUES 779
MACROSCOPIC 779
MICROSCOPIC 779
DIFFERENTIAL DIAGNOSIS 779
DIAGNOSTIC CHECKLIST 779
SELECTED REFERENCES 779
Chapter 181.\rCandidiasis 780
TERMINOLOGY 781
ETIOLOGY/PATHOGENESIS 781
CLINICAL ISSUES 781
IMAGING 781
MACROSCOPIC 781
MICROSCOPIC 781
DIFFERENTIAL DIAGNOSIS 781
DIAGNOSTIC CHECKLIST 781
SELECTED REFERENCES 781
Chapter 182.\rHistoplasmosis 782
ETIOLOGY/PATHOGENESIS 783
CLINICAL ISSUES 783
MACROSCOPIC 783
MICROSCOPIC 783
DIFFERENTIAL DIAGNOSIS 783
DIAGNOSTIC CHECKLIST 783
SELECTED REFERENCES 783
Chapter 183.\rCoccidioidomycosis 784
TERMINOLOGY 785
ETIOLOGY/PATHOGENESIS 785
CLINICAL ISSUES 785
IMAGING 785
MACROSCOPIC 785
MICROSCOPIC 785
DIFFERENTIAL DIAGNOSIS 785
DIAGNOSTIC CHECKLIST 785
SELECTED REFERENCES 785
Chapter 184.\rBlastomycosis 786
ETIOLOGY/PATHOGENESIS 787
CLINICAL ISSUES 787
MACROSCOPIC 787
MICROSCOPIC 787
DIFFERENTIAL DIAGNOSIS 787
DIAGNOSTIC CHECKLIST 787
SELECTED REFERENCES 787
Chapter 185.\rParacoccidioidomycosis 788
TERMINOLOGY 789
ETIOLOGY/PATHOGENESIS 789
CLINICAL ISSUES 789
MICROSCOPIC 789
DIFFERENTIAL DIAGNOSIS 789
DIAGNOSTIC CHECKLIST 789
SELECTED REFERENCES 789
Chapter 186.\rAspergillosis 790
TERMINOLOGY 791
ETIOLOGY/PATHOGENESIS 791
CLINICAL ISSUES 791
IMAGING 791
MACROSCOPIC 791
MICROSCOPIC 791
DIFFERENTIAL DIAGNOSIS 791
DIAGNOSTIC CHECKLIST 791
SELECTED REFERENCES 791
Chapter 187.\rCryptococcosis 792
TERMINOLOGY 793
ETIOLOGY/PATHOGENESIS 793
CLINICAL ISSUES 793
MACROSCOPIC 793
MICROSCOPIC 793
DIFFERENTIAL DIAGNOSIS 793
SELECTED REFERENCES 793
Chapter 188.\rMicrosporidiosis 794
TERMINOLOGY 795
ETIOLOGY/PATHOGENESIS 795
CLINICAL ISSUES 795
MICROSCOPIC 795
ANCILLARY TESTS 795
DIFFERENTIAL DIAGNOSIS 795
SELECTED REFERENCES 795
Chapter 189.\rRickettsial Infections 796
TERMINOLOGY 797
ETIOLOGY/PATHOGENESIS 797
CLINICAL ISSUES 797
MACROSCOPIC 797
MICROSCOPIC 797
ANCILLARY TESTS 797
DIFFERENTIAL DIAGNOSIS 797
DIAGNOSTIC CHECKLIST 797
SELECTED REFERENCES 797
Chapter 190.\rToxoplasmosis 798
TERMINOLOGY 799
ETIOLOGY/PATHOGENESIS 799
CLINICAL ISSUES 799
MICROSCOPIC 799
ANCILLARY TESTS 799
DIFFERENTIAL DIAGNOSIS 799
SELECTED REFERENCES 799
Chapter 191.\rHydatidosis 800
TERMINOLOGY 801
ETIOLOGY/PATHOGENESIS 801
CLINICAL ISSUES 801
IMAGING 801
MACROSCOPIC 801
MICROSCOPIC 801
ANCILLARY TESTS 801
DIFFERENTIAL DIAGNOSIS 801
DIAGNOSTIC CHECKLIST 801
SELECTED REFERENCES 801
Chapter 192.\rPolyomavirus Nephritis 804
TERMINOLOGY 805
ETIOLOGY/PATHOGENESIS 805
CLINICAL ISSUES 805
MICROSCOPIC 805
ANCILLARY TESTS 806
DIFFERENTIAL DIAGNOSIS 806
DIAGNOSTIC CHECKLIST 806
SELECTED REFERENCES 806
Chapter 193.\rAdenovirus Infection 812
ETIOLOGY/PATHOGENESIS 813
CLINICAL ISSUES 813
MACROSCOPIC 813
MICROSCOPIC 813
ANCILLARY TESTS 813
DIFFERENTIAL DIAGNOSIS 813
DIAGNOSTIC CHECKLIST 813
SELECTED REFERENCES 813
Chapter 194.\rCytomegalovirus Infection 816
TERMINOLOGY 817
ETIOLOGY/PATHOGENESIS 817
CLINICAL ISSUES 817
MICROSCOPIC 818
ANCILLARY TESTS 818
DIFFERENTIAL DIAGNOSIS 818
DIAGNOSTIC CHECKLIST 818
SELECTED REFERENCES 818
Chapter 195.\rHerpes Simplex Acute Nephritis 820
TERMINOLOGY 821
ETIOLOGY/PATHOGENESIS 821
CLINICAL ISSUES 821
MICROSCOPIC 821
ANCILLARY TESTS 821
DIFFERENTIAL DIAGNOSIS 821
DIAGNOSTIC CHECKLIST 821
SELECTED REFERENCES 821
Chapter 196.\rEpstein-Barr Virus Nephritis 822
TERMINOLOGY 823
ETIOLOGY/PATHOGENESIS 823
CLINICAL ISSUES 823
MICROSCOPIC 823
ANCILLARY TESTS 823
DIFFERENTIAL DIAGNOSIS 823
DIAGNOSTIC CHECKLIST 823
SELECTED REFERENCES 823
Chapter 197.\rHantavirus Nephropathy 824
TERMINOLOGY 825
ETIOLOGY/PATHOGENESIS 825
CLINICAL ISSUES 825
MICROSCOPIC 825
ANCILLARY TESTS 825
DIFFERENTIAL DIAGNOSIS 825
SELECTED REFERENCES 825
SECTION 6:\rDevelopmental Diseases 827
Chapter 198.\rOverview of Congenital Anomalies of the Kidney and Urinary Tract 828
TERMINOLOGY 828
ETIOLOGY/PATHOGENESIS 828
EPIDEMIOLOGY 829
CLINICAL IMPLICATIONS 829
MACROSCOPIC 829
MICROSCOPIC 829
SELECTED REFERENCES 829
Chapter 199.\rDysplasia/Hypoplasia/Agenesis 832
TERMINOLOGY 833
ETIOLOGY/PATHOGENESIS 833
CLINICAL ISSUES 833
MACROSCOPIC 834
MICROSCOPIC 834
ANCILLARY TESTS 834
DIFFERENTIAL DIAGNOSIS 834
DIAGNOSTIC CHECKLIST 835
SELECTED REFERENCES 835
Chapter 200.\rOligomeganephronia 838
TERMINOLOGY 839
ETIOLOGY/PATHOGENESIS 839
CLINICAL ISSUES 839
IMAGING 839
MACROSCOPIC 839
MICROSCOPIC 839
DIFFERENTIAL DIAGNOSIS 839
DIAGNOSTIC CHECKLIST 839
SELECTED REFERENCES 839
Chapter 201.\rEctopia, Malrotation, Duplication, Fusion, Supernumerary Kidney 840
ETIOLOGY/PATHOGENESIS 841
CLINICAL ISSUES 841
MACROSCOPIC 841
MICROSCOPIC 842
DIFFERENTIAL DIAGNOSIS 842
DIAGNOSTIC CHECKLIST 842
SELECTED REFERENCES 842
Chapter 202.\rAsk-Upmark Kidney 844
TERMINOLOGY 845
ETIOLOGY/PATHOGENESIS 845
CLINICAL ISSUES 845
IMAGING 845
MACROSCOPIC 845
MICROSCOPIC 845
DIFFERENTIAL DIAGNOSIS 845
SELECTED REFERENCES 845
Chapter 203.\rRenal Tubular Dysgenesis 846
TERMINOLOGY 847
ETIOLOGY/PATHOGENESIS 847
CLINICAL ISSUES 847
MACROSCOPIC 847
MICROSCOPIC 847
ANCILLARY TESTS 847
DIFFERENTIAL DIAGNOSIS 847
DIAGNOSTIC CHECKLIST 847
SELECTED REFERENCES 847
SECTION 7:\rCystic Diseases 851
Chapter 204.\rOverview of Cystic Diseases 852
PATHOGENETIC CLASSIFICATION 852
EPIDEMIOLOGY 852
ETIOLOGY/PATHOGENESIS 852
MACROSCOPIC 852
MICROSCOPIC 853
HEREDITARY CYSTIC DISEASES 853
NONHEREDITARY CYSTIC DISEASES 853
NONNEPHRON CYSTIC DISEASE 854
MIMICS OF CYSTIC DISEASES 854
SELECTED REFERENCES 854
Chapter 205.\rAutosomal Dominant Polycystic Kidney Disease 858
TERMINOLOGY 859
ETIOLOGY/PATHOGENESIS 859
CLINICAL ISSUES 859
MACROSCOPIC 859
MICROSCOPIC 859
DIFFERENTIAL DIAGNOSIS 859
DIAGNOSTIC CHECKLIST 859
SELECTED REFERENCES 859
Chapter 206.\rAutosomal Recessive Polycystic Kidney Disease 862
TERMINOLOGY 863
ETIOLOGY/PATHOGENESIS 863
CLINICAL ISSUES 863
IMAGING 863
MACROSCOPIC 863
MICROSCOPIC 863
ANCILLARY TESTS 863
DIFFERENTIAL DIAGNOSIS 863
SELECTED REFERENCES 863
Chapter 207.\rNephronophthisis and Related Ciliopathies 868
TERMINOLOGY 869
ETIOLOGY/PATHOGENESIS 869
CLINICAL ISSUES 869
MACROSCOPIC 869
MICROSCOPIC 869
ANCILLARY TESTS 869
DIFFERENTIAL DIAGNOSIS 869
DIAGNOSTIC CHECKLIST 870
SELECTED REFERENCES 870
Chapter 208.\rvon Hippel-Lindau Disease 874
TERMINOLOGY 875
ETIOLOGY/PATHOGENESIS 875
CLINICAL ISSUES 875
MACROSCOPIC 875
MICROSCOPIC 875
DIFFERENTIAL DIAGNOSIS 875
DIAGNOSTIC CHECKLIST 875
SELECTED REFERENCES 875
Chapter 209.\rTuberous Sclerosis Complex 880
TERMINOLOGY 881
ETIOLOGY/PATHOGENESIS 881
CLINICAL ISSUES 881
IMAGING 881
MACROSCOPIC 881
MICROSCOPIC 882
ANCILLARY TESTS 882
DIFFERENTIAL DIAGNOSIS 882
DIAGNOSTIC CHECKLIST 882
SELECTED REFERENCES 882
Chapter 210. Zellweger Syndrome 886
TERMINOLOGY 887
ETIOLOGY/PATHOGENESIS 887
CLINICAL ISSUES 887
IMAGING 887
MACROSCOPIC 887
MICROSCOPIC 887
ANCILLARY TESTS 887
DIFFERENTIAL DIAGNOSIS 887
SELECTED REFERENCES 887
Chapter 211.\rMedullary Sponge Kidney 890
TERMINOLOGY 891
ETIOLOGY/PATHOGENESIS 891
CLINICAL ISSUES 891
IMAGING 891
MACROSCOPIC 891
MICROSCOPIC 891
DIFFERENTIAL DIAGNOSIS 891
SELECTED REFERENCES 891
Chapter 212.\rCystic Nephroma 892
TERMINOLOGY 893
ETIOLOGY/PATHOGENESIS 893
CLINICAL ISSUES 893
IMAGING 893
MACROSCOPIC 893
MICROSCOPIC 893
ANCILLARY TESTS 893
DIFFERENTIAL DIAGNOSIS 893
SELECTED REFERENCES 893
Chapter 213.\rAcquired Cystic Disease 896
TERMINOLOGY 897
ETIOLOGY/PATHOGENESIS 897
CLINICAL ISSUES 897
MACROSCOPIC 897
MICROSCOPIC 897
ANCILLARY TESTS 897
DIFFERENTIAL DIAGNOSIS 897
DIAGNOSTIC CHECKLIST 897
SELECTED REFERENCES 897
Chapter 214.\rSimple and Miscellaneous Cysts 900
ETIOLOGY/PATHOGENESIS 901
CLINICAL ISSUES 901
MACROSCOPIC 901
MICROSCOPIC 901
DIFFERENTIAL DIAGNOSIS 901
SELECTED REFERENCES 901
Chapter 215.\rRenal Lymphangioma/Lymphangiectasia 902
TERMINOLOGY 903
ETIOLOGY/PATHOGENESIS 903
CLINICAL ISSUES 903
MACROSCOPIC 903
MICROSCOPIC 903
DIFFERENTIAL DIAGNOSIS 903
SELECTED REFERENCES 903
SECTION 8:\rDiseases of the Collecting System 907
Chapter 216.\rIntroduction to Impediments to Urine Flow 908
TERMINOLOGY 908
CLASSIFICATION 908
ETIOLOGY/PATHOGENESIS 909
CLINICAL IMPLICATIONS 909
MACROSCOPIC 909
MICROSCOPIC 910
SELECTED REFERENCES 910
Chapter 217.\rReflux Nephropathy 912
TERMINOLOGY 913
ETIOLOGY/PATHOGENESIS 913
CLINICAL ISSUES 913
IMAGING 913
MACROSCOPIC 913
MICROSCOPIC 913
ANCILLARY TESTS 914
DIFFERENTIAL DIAGNOSIS 914
DIAGNOSTIC CHECKLIST 914
SELECTED REFERENCES 914
Chapter 218.\rObstructive Nephropathy 918
TERMINOLOGY 919
ETIOLOGY/PATHOGENESIS 919
CLINICAL ISSUES 919
IMAGING 919
MACROSCOPIC 919
MICROSCOPIC 919
DIFFERENTIAL DIAGNOSIS 919
SELECTED REFERENCES 919
Chapter 219.\rNephrolithiasis 924
TERMINOLOGY 925
ETIOLOGY/PATHOGENESIS 925
CLINICAL ISSUES 925
MACROSCOPIC 925
MICROSCOPIC 926
ANCILLARY TESTS 926
DIFFERENTIAL DIAGNOSIS 926
DIAGNOSTIC CHECKLIST 926
SELECTED REFERENCES 926
Chapter 220.\rLoin Pain Hematuria Syndrome 932
TERMINOLOGY 933
ETIOLOGY/PATHOGENESIS 933
CLINICAL ISSUES 933
IMAGING 933
MICROSCOPIC 933
ANCILLARY TESTS 933
DIFFERENTIAL DIAGNOSIS 933
DIAGNOSTIC CHECKLIST 933
SELECTED REFERENCES 933
SECTION 9:\rDiseases of the Renal Allograft 937
Chapter 221.\rPathological Classification of Renal Allograft Diseases 938
TERMINOLOGY 938
DEFINITIONS 938
CATEGORY 1: ALLOIMMUNE RESPONSES 938
CATEGORY 2: DRUG TOXICITY AND\rHYPERSENSITIVITY 938
CATEGORY 3: INFECTION 939
CATEGORY 4: ANATOMIC COMPLICATIONS 939
CATEGORY 5: RECURRENT AND DE NOVO\rDISEASES 939
CATEGORY 6: DONOR DISEASE 939
CATEGORY 7: OTHER DISEASES 939
NOTES 939
SELECTED REFERENCES 939
Chapter 222.\rEvaluation of the Allograft Kidney 940
TERMINOLOGY 940
ETIOLOGY/PATHOGENESIS 940
CLINICAL IMPLICATIONS 940
BIOPSY PROCESSING 941
EVALUATION OF BIOPSY 941
SPECIAL CONSIDERATIONS IN TRANSPLANT\rBIOPSIES 941
NEW APPROACHES 941
PROTOCOL BIOPSIES (SURVEILLANCE\rBIOPSIES) 941
BANFF CLASSIFICATION 942
BANFF SCORING CATEGORIES 943
SELECTED REFERENCES 943
Chapter 223.\rEvaluation of the Donor Kidney 944
TERMINOLOGY 945
CLINICAL ISSUES 945
MICROSCOPIC 945
ANCILLARY TESTS 946
DIAGNOSTIC CHECKLIST 946
REPORTING 946
SELECTED REFERENCES 946
Chapter 224.\rAcute T-Cell-Mediated Rejection 948
TERMINOLOGY 949
ETIOLOGY/PATHOGENESIS 949
CLINICAL ISSUES 949
MICROSCOPIC 949
ANCILLARY TESTS 950
DIFFERENTIAL DIAGNOSIS 950
DIAGNOSTIC CHECKLIST 950
GRADING 950
SELECTED REFERENCES 950
Chapter 225.\rChronic T-Cell-Mediated Rejection 958
TERMINOLOGY 959
ETIOLOGY/PATHOGENESIS 959
CLINICAL ISSUES 959
MICROSCOPIC 959
ANCILLARY TESTS 959
DIFFERENTIAL DIAGNOSIS 959
DIAGNOSTIC CHECKLIST 959
SELECTED REFERENCES 959
Chapter 226.\rHyperacute Rejection 960
TERMINOLOGY 961
ETIOLOGY/PATHOGENESIS 961
CLINICAL ISSUES 961
MACROSCOPIC 961
MICROSCOPIC 961
ANCILLARY TESTS 961
DIFFERENTIAL DIAGNOSIS 961
SELECTED REFERENCES 961
Chapter 227.\rAcute Humoral Rejection 964
TERMINOLOGY 965
ETIOLOGY/PATHOGENESIS 965
CLINICAL ISSUES 965
MICROSCOPIC 965
ANCILLARY TESTS 966
DIFFERENTIAL DIAGNOSIS 966
SELECTED REFERENCES 966
Chapter 228.\rChronic Antibody-Mediated Rejection 970
TERMINOLOGY 971
ETIOLOGY/PATHOGENESIS 971
CLINICAL ISSUES 971
MICROSCOPIC 971
ANCILLARY TESTS 972
DIFFERENTIAL DIAGNOSIS 972
DIAGNOSTIC CHECKLIST 973
REPORTING 973
SELECTED REFERENCES 973
Chapter 229.\rDiseases That Recur in Allografts 980
TERMINOLOGY 981
ETIOLOGY/PATHOGENESIS 981
CLINICAL ISSUES 981
MICROSCOPIC 982
DIFFERENTIAL DIAGNOSIS 982
DIAGNOSTIC CHECKLIST 983
SELECTED REFERENCES 983
Chapter 230.\rDe Novo Focal Segmental Glomerulosclerosis 988
TERMINOLOGY 989
ETIOLOGY/PATHOGENESIS 989
CLINICAL ISSUES 989
MICROSCOPIC 989
ANCILLARY TESTS 989
DIFFERENTIAL DIAGNOSIS 989
DIAGNOSTIC CHECKLIST 989
SELECTED REFERENCES 989
Chapter 231.\rDe Novo Membranous Glomerulonephritis 990
TERMINOLOGY 991
ETIOLOGY/PATHOGENESIS 991
CLINICAL ISSUES 991
MACROSCOPIC 991
MICROSCOPIC 991
ANCILLARY TESTS 991
DIFFERENTIAL DIAGNOSIS 991
DIAGNOSTIC CHECKLIST 991
SELECTED REFERENCES 991
Chapter 232.\rAnti-GBM Disease in Alport Syndrome 994
TERMINOLOGY 995
ETIOLOGY/PATHOGENESIS 995
CLINICAL ISSUES 995
MICROSCOPIC 995
ANCILLARY TESTS 995
DIFFERENTIAL DIAGNOSIS 995
DIAGNOSTIC CHECKLIST 995
SELECTED REFERENCES 995
Chapter 233.\rHyperperfusion Injury 996
TERMINOLOGY 997
ETIOLOGY/PATHOGENESIS 997
CLINICAL ISSUES 997
MICROSCOPIC 997
ANCILLARY TESTS 997
DIFFERENTIAL DIAGNOSIS 997
DIAGNOSTIC CHECKLIST 997
SELECTED REFERENCES 997
Chapter 234.\rEngraftment Syndrome 998
TERMINOLOGY 999
ETIOLOGY/PATHOGENESIS 999
CLINICAL ISSUES 999
MICROSCOPIC 999
ANCILLARY TESTS 999
DIFFERENTIAL DIAGNOSIS 999
SELECTED REFERENCES 999
Chapter 235.\rAcute Tubular Injury in Allografts 1002
TERMINOLOGY 1003
ETIOLOGY/PATHOGENESIS 1003
CLINICAL ISSUES 1003
MACROSCOPIC 1003
MICROSCOPIC 1003
ANCILLARY TESTS 1003
DIFFERENTIAL DIAGNOSIS 1003
DIAGNOSTIC CHECKLIST 1003
SELECTED REFERENCES 1003
Chapter 236.\rUrine Leak 1004
TERMINOLOGY 1005
ETIOLOGY/PATHOGENESIS 1005
CLINICAL ISSUES 1005
IMAGING 1005
MICROSCOPIC 1005
DIFFERENTIAL DIAGNOSIS 1005
SELECTED REFERENCES 1005
Chapter 237.\rLymphocele 1006
TERMINOLOGY 1007
ETIOLOGY/PATHOGENESIS 1007
CLINICAL ISSUES 1007
IMAGING 1007
MACROSCOPIC 1007
MICROSCOPIC 1007
DIFFERENTIAL DIAGNOSIS 1007
DIAGNOSTIC CHECKLIST 1007
SELECTED REFERENCES 1007
Chapter 238.\rRenal Artery or Vein Thrombosis 1008
TERMINOLOGY 1009
ETIOLOGY/PATHOGENESIS 1009
CLINICAL ISSUES 1009
IMAGING 1009
MACROSCOPIC 1009
MICROSCOPIC 1009
DIFFERENTIAL DIAGNOSIS 1009
DIAGNOSTIC CHECKLIST 1009
SELECTED REFERENCES 1009
Chapter 239.\rTransplant Renal Artery Stenosis 1010
TERMINOLOGY 1011
ETIOLOGY/PATHOGENESIS 1011
CLINICAL ISSUES 1011
IMAGING 1011
MACROSCOPIC 1011
MICROSCOPIC 1011
DIFFERENTIAL DIAGNOSIS 1011
DIAGNOSTIC CHECKLIST 1011
SELECTED REFERENCES 1011
Chapter 240.\rPost-Transplant Lymphoproliferative Disease 1012
TERMINOLOGY 1013
ETIOLOGY/PATHOGENESIS 1013
CLINICAL ISSUES 1013
IMAGING 1014
MACROSCOPIC 1014
MICROSCOPIC 1014
ANCILLARY TESTS 1015
DIFFERENTIAL DIAGNOSIS 1015
DIAGNOSTIC CHECKLIST 1015
REPORTING 1015
SELECTED REFERENCES 1016
Chapter 241.\rProtocol Biopsies 1022
TERMINOLOGY 1022
CLINICAL IMPLICATIONS 1022
MICROSCOPIC 1022
DIAGNOSES 1023
SELECTED REFERENCES 1023
Chapter 242.\rAccommodation 1026
TERMINOLOGY 1027
ETIOLOGY/PATHOGENESIS 1027
CLINICAL ISSUES 1027
MICROSCOPIC 1027
ANCILLARY TESTS 1027
DIFFERENTIAL DIAGNOSIS 1027
DIAGNOSTIC CHECKLIST 1027
SELECTED REFERENCES 1027
Chapter 243.\rTolerance 1028
TERMINOLOGY 1029
ETIOLOGY/PATHOGENESIS 1029
CLINICAL ISSUES 1029
MICROSCOPIC 1029
DIAGNOSTIC CHECKLIST 1029
SELECTED REFERENCES 1029
Chapter 244.\rKidney Diseases in Non-Renal Transplant Recipients 1030
TERMINOLOGY 1031
ETIOLOGY/PATHOGENESIS 1031
CLINICAL ISSUES 1031
MICROSCOPIC 1031
ANCILLARY TESTS 1031
DIAGNOSTIC CHECKLIST 1032
SELECTED REFERENCES 1032
Chapter 245.\rGraft-vs.-Host Glomerulopathies 1034
TERMINOLOGY 1035
ETIOLOGY/PATHOGENESIS 1035
CLINICAL ISSUES 1035
MICROSCOPIC 1035
ANCILLARY TESTS 1035
DIFFERENTIAL DIAGNOSIS 1035
SELECTED REFERENCES 1035
SECTION 10:\rProtocols 1037
Chapter 246.\rBiopsy Reports 1038
TERMINOLOGY 1038
COMPONENTS OF BIOPSY REPORT 1038
SELECTED REFERENCES 1039
Chapter 247.\rExamination of the End-Stage Kidney 1040
TERMINOLOGY 1040
EPIDEMIOLOGY 1040
ETIOLOGY/PATHOGENESIS 1040
MACROSCOPIC 1041
MICROSCOPIC 1041
SELECTED REFERENCES 1042
Chapter 248.\rExamination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases 1046
TERMINOLOGY 1046
EPIDEMIOLOGY 1046
ETIOLOGY/PATHOGENESIS 1046
CLINICAL IMPLICATIONS 1046
MACROSCOPIC 1047
MICROSCOPIC 1047
SELECTED REFERENCES 1047
Chapter 249.\rEvaluation of the Transplant Nephrectomy 1052
TERMINOLOGY 1052
ETIOLOGY/PATHOGENESIS 1052
CLINICAL IMPLICATIONS 1053
MACROSCOPIC 1053
MICROSCOPIC 1053
SELECTED REFERENCES 1053
Chapter 250.\rNeedle Biopsy: Evaluation for Adequacy 1058
SURGICAL/CLINICAL CONSIDERATION 1058
SPECIMEN EVALUATION 1058
REPORTING 1059
PITFALLS 1059
SELECTED REFERENCES 1059
Chapter 251.\rEvaluation of Fibrosis 1062
TERMINOLOGY 1062
VALUE 1062
MECHANISMS 1062
METHODS FOR ASSESSMENT 1062
SELECTED REFERENCES 1063
Chapter 252.\rImmunofluorescence on Paraffin Tissue Sections 1066
TERMINOLOGY 1066
DIAGNOSTIC VALUE 1066
PROTOCOLS 1066
SELECTED REFERENCES 1066
Chapter 253.\rEM Processing From Paraffin or Frozen Tissue 1068
TERMINOLOGY 1068
CLINICAL IMPLICATIONS 1068
MACROSCOPIC 1068
PROTOCOLS 1068
MICROSCOPIC 1069
SELECTED REFERENCES 1069
Chapter 254.\rDetection of PLA2R Deposits and Autoantibodies 1070
TERMINOLOGY 1070
CLINICAL VALUE 1070
PROTOCOLS 1070
SELECTED REFERENCES 1070
Chapter 255.\rAlport Collagen IV Immunofluorescence 1072
TERMINOLOGY 1072
IMMUNOFLUORESCENCE TECHNIQUE 1072
INTERPRETATION 1072
SELECTED REFERENCES 1072
Chapter 256.\rC4d Immunohistochemistry/Immunofluorescence 1074
TERMINOLOGY 1074
COMPLEMENT COMPONENTS 1074
DIAGNOSTIC VALUE 1074
IMMUNOFLUORESCENCE TECHNIQUE (IF) 1074
IMMUNOHISTOCHEMICAL TECHNIQUE (IHC) 1075
DIAGNOSTIC SPECIFICITY 1075
CONTROLS 1075
SELECTED REFERENCES 1075
Chapter 257.\rPolyomavirus Detection in Tissue 1078
TERMINOLOGY 1078
PROTOCOLS 1078
SELECTED REFERENCES 1078
Chapter 258.\rDiagnostic Genetics of Kidney Diseases 1080
TERMINOLOGY 1080
KIDNEY DISEASES AMENABLE TO\rDIAGNOSTIC CLINICAL SEQUENCING 1080
ETIOLOGY/PATHOGENESIS 1080
DIAGNOSTIC METHODS AND APPLICATIONS 1081
TYPICAL STEPS IN WES ANALYSIS 1081
CLINICAL IMPLICATIONS 1082
SELECTED REFERENCES 1082
INDEX I-i