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Netter's Atlas of Neuroscience E-Book

Netter's Atlas of Neuroscience E-Book

David L. Felten | Michael K. O'Banion | Mary E Maida

(2015)

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Book Details

Abstract

Ideal for students of neuroscience and neuroanatomy, the new edition of Netter's Atlas of Neuroscience combines the didactic well-loved illustrations of Dr. Frank Netter with succinct text and clinical points, providing a highly visual, clinically oriented guide to the most important topics in this subject. The logically organized content presents neuroscience from three perspectives: an overview of the nervous system, regional neuroscience, and systemic neuroscience, enabling you to review complex neural structures and systems from different contexts.

You may also be interested in:

A companion set of flash cards, Netter’s Neuroscience Flash Cards, 3rd Edition, to which the textbook is cross-referenced.

  • Coverage of both regional and systemic neurosciences allows you to learn structure and function in different and important contexts.
  • Combines the precision and beauty of Netter and Netter-style illustrations to highlight key neuroanatomical concepts and clinical correlations.
  • Reflects the current understanding of the neural components and supportive tissue, regions, and systems of the brain, spinal cord, and periphery.
  • Uniquely informative drawings provide a quick and memorable overview of anatomy, function, and clinical relevance.
  • Succinct and useful format utilizes tables and short text to offer easily accessible "at-a-glance" information.
  • Provides an overview of the basic features of the spinal cord, brain, and peripheral nervous system, the vasculature, meninges and cerebrospinal fluid, and basic development.
  • Integrates the peripheral and central aspects of the nervous system.
  • Bridges neuroanatomy and neurology through the use of correlative radiographs.
  • Highlights cross-sectional brain stem anatomy and side-by-side comparisons of horizontal sections, CTs and MRIs.
  • Expanded coverage of cellular and molecular neuroscience provides essential guidance on signaling, transcription factors, stem cells, evoked potentials, neuronal and glial function, and a number of molecular breakthroughs for a better understanding of normal and pathologic conditions of the nervous system.
  • Micrographs, radiologic imaging, and stained cross sections supplement illustrations for a comprehensive visual understanding.
  • Increased clinical points -- from sleep disorders and inflammation in the CNS to the biology of seizures and the mechanisms of Alzheimer's -- offer concise insights that bridge basic neuroscience and clinical application.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Marketing ad i
Netter's Atlas of Neuroscience ii
Copyright Page iv
About the Authors v
Dedication vii
Acknowledgments ix
Preface xi
Organization of Netter’s Atlas of Neuroscience xii
About the Artists xiii
Table Of Contents xv
Video Contents xvii
I Overview of the Nervous System 1
1 Neurons and Their Properties 3
Anatomical and Molecular Properties 4
1.1 Neuronal Structure 4
1.2 3D Neuronal Structure And Neurohistology 5
1.3 Types of Synapses 6
1.4 Neuronal Cell Types 7
1.5 Glial Cell Types 8
1.6 Astrocyte Biology 9
1.7 Microglial Biology 10
1.8 Oligodendrocyte Biology 11
1.9 Neuronal Growth Factors And Trophic Factors 12
1.10 Stem Cells In The CNS: Intrinsic And Extrinsic Mechanisms 13
1.11 Stem Cell Therapy 14
1.12 Blood-Brain Barrier 15
1.13 Inflammation in the CNS 16
1.14 Axonal Transport in the CNS and PNS 17
1.15 Myelination of CNS and PNS Axons 18
1.16 Development of Myelination and Axon Ensheathment 19
Electrical Properties 20
1.17 Neuronal Resting Potential 20
1.18 Neuronal Membrane Potential and Sodium Channels 21
1.19 Graded Potentials in Neurons 22
1.20 Mechanisms of Excitatory Postsynaptic Potentials and Inhibitory Postsynaptic Potentials 23
1.21 Action Potentials 24
1.22 Propagation of the Action Potential 25
1.23 Conduction Velocity 26
1.24 Classification of Peripheral Nerve Fibers by Size and Conduction Velocity 27
1.25 Electromyography and Conduction Velocity Studies 28
1.26 Presynaptic and Postsynaptic Inhibition 29
1.27 Spatial and Temporal Summation 30
1.28 Normal Electrical Firing Patterns of Cortical Neurons and the Origin and Spread of Seizures 31
1.29 Electroencephalography 32
1.30 Types of Electrical Discharges in Generalized Seizures and Sites of Action of Antiseizure Medications 33
1.31 Visual and Auditory Evoked Potentials 34
Neurotransmitter and Signaling Properties 35
1.32 Synaptic Morphology 35
1.33 Mechanisms of Molecular Signaling in Neurons 36
1.34 Neurotransmitter Release 37
1.35 Multiple Neurotransmitter Synthesis, Release, and Signaling from Individual Neurons 38
1.36 Neuronal Signal Transduction: Local Regulation of Synaptic Strength at An Excitatory Synapse 39
1.37 Neuronal Signal Transduction: Regulation of Nuclear Signaling 40
1.38 Glucocorticoid Regulation of Neurons and Apoptosis 41
1.39 Chemical Neurotransmission 43
Amino Acid Synapse 43
Catecholamine Synapse 43
Serotonin Synapse 43
Peptide Synapses 43
Acetylcholine (Cholinergic) Synapse 43
2 Skull and Meninges 45
2.1 Interior View of the Base of the Adult Skull 46
2.2 Foramina in the Base of the Adult Skull 47
2.3 Bony Framework of the Head and Neck 48
2.4 Schematic of the Meninges and Their Relationships to the Brain and Skull 49
2.5 Hematomas 50
3 Brain 51
3.1 Surface Anatomy of the Forebrain: Lateral View 52
3.2 Lateral View of the Forebrain: Functional Regions 53
3.3 Lateral View of the Forebrain: Brodmann’s Areas 54
3.4 Anatomy of the Medial (Midsagittal) Surface of the Brain in Situ 55
3.5 Anatomy of the Medial (Midsagittal) Surface of the Brain, with Brain Stem Removed 56
3.6 Medial Surface of the Brain 57
3.7 Anatomy of the Basal Surface of the Brain, with the Brain Stem and Cerebellum Removed 58
3.8 Basal Surface of the Brain: Functional Areas and Brodmann’s Areas 59
3.9 Brain Imaging: Computed Tomography Scans, Coronal and Sagittal 60
3.10 Brain Imaging: Magnetic Resonance Imaging, Axial and Sagittal T1-Weighted Images 61
3.11 Brain Imaging: Magnetic Resonance Imaging, Axial and Sagittal T2-Weighted Images 62
3.12 Positron Emission Tomography Scanning 63
3.13 Horizontal Brain Sections Showing the Basal Ganglia 64
3.14 Major Limbic Forebrain Structures 65
3.15 Corpus Callosum 66
3.16 Color Imaging of the Corpus Callosum by Diffusion Tensor Imaging 67
3.17 Hippocampal Formation and Fornix 68
3.18 Thalamic Anatomy 69
3.19 Thalamic Nuclei 70
4 Brain Stem and Cerebellum 71
4.1 Brain Stem Surface Anatomy: Posterolateral View 72
4.2 Brain Stem Surface Anatomy: Anterior View 73
4.3 Cerebellar Anatomy: External Features 74
4.4 Cerebellar Anatomy: Internal Features 75
5 Spinal Cord 77
5.1 Spinal Column: Bony Anatomy 78
5.2 Lumbar Vertebrae: Radiography 79
5.3 Spinal Cord: Gross Anatomy in Situ 80
5.4 The Spinal Cord: Its Meninges and Spinal Roots 81
5.5 Spinal Cord: Cross-Sectional Anatomy in Situ 82
5.6 Spinal Cord: White and Gray Matter 83
6 Ventricles and the Cerebrospinal Fluid 85
6.1 Ventricular Anatomy 86
6.2 Ventricular Anatomy in Coronal Forebrain Section 87
6.3 Anatomy of the Fourth Ventricle: Posterior View with Cerebellum Removed 88
6.4 Anatomy of the Fourth Ventricle: Lateral View 89
6.5 Magnetic Resonance Imaging of the Ventricles: Axial and Coronal Views 90
6.6 Circulation of the Cerebrospinal Fluid 91
7 Vasculature 93
Arterial System 94
7.1 Meningeal Arteries: Relationship to Skull and Dura 94
7.2 Arterial Supply to the Brain and Meninges 95
7.3 Common Sites of Cerebrovascular Occlusive Disease 96
7.4 Internal Carotid and Ophthalmic Artery Course 97
7.5 Arterial Distribution to the Brain: Basal View 98
7.6 Arterial Distribution to the Brain: Cutaway Basal View Showing the Circle of Willis 99
7.7 Arterial Distribution to the Brain: Frontal View with Hemispheres Retracted 100
7.8 Arterial Distribution to the Brain: Coronal Forebrain Section 101
7.9 Types of Strokes 102
7.10 Schematic of Arteries to the Brain 103
7.11 Circle of Willis: Schematic Illustration and Vessels in Situ 104
7.12 Arterial Distribution to the Brain: Lateral and Medial Views 105
7.13 Territories of the Cerebral Arteries 106
7.14 Magnetic Resonance Angiography: Frontal and Lateral Views 107
7.15 Angiographic Anatomy of the Internal Carotid Circulation 108
7.16 Vertebrobasilar Arterial System 109
7.17 Angiographic Anatomy of the Vertebrobasilar System 110
7.18 Occlusive Sites of the Vertebrobasilar System 111
7.19 Vascular Supply to the Hypothalamus and the Pituitary Gland 112
7.20 Arterial Blood Supply to the Spinal Cord: Longitudinal View 113
7.21 Anterior and Posterior Spinal Arteries and Their Distribution 114
7.22 Arterial Supply to the Spinal Cord: Cross-Sectional View 115
Venous System 116
7.23 Meninges and Superficial Cerebral Veins 116
7.24 Veins: Superficial Cerebral, Meningeal, Diploic, and Emissary 117
7.25 Venous Sinuses 118
7.26 Deep Venous Drainage of the Brain 119
7.27 Deep Venous Drainage of the Brain: Relationship to the Ventricles 120
7.28 Carotid Venograms: Venous Phase 121
7.29 Magnetic Resonance Venography: Coronal and Sagittal Views 122
7.30 Venous Drainage of the Brain Stem and the Cerebellum 123
7.31 Venous Drainage of the Spinal Cord 124
8 Developmental Neuroscience 125
8.1 Formation of the Neural Plate, Neural Tube, and Neural Crest 126
8.2 Neurulation 127
8.3 Neural Tube Development and Neural Crest Formation 128
8.4 Development of Peripheral Axons 129
8.5 Somatic Versus Splanchnic Nerve Development 130
8.6 Limb Rotation and Dermatomes 131
8.7 Neural Proliferation and Differentiation: Walls of the Neural Tube 132
8.8 Neural Tube and Neural Crest Derivatives 133
8.9 Early Brain Development: the 28-Day-Old Embryo 134
8.10 Early Brain Development: the 36-Day-Old Embryo 135
8.11 Early Brain Development: the 49-Day-Old Embryo and the 3-Month-Old Embryo 136
8.12 Forebrain Development: 7 Weeks Through 3 Months 137
8.13 The 6-Month and 9-Month Central Nervous Systems 138
8.14 Neurogenesis and Cell Migration in the Developing Neocortex 139
8.15 Comparison of -Week and Adult Central Nervous System Regions 140
8.16 Alar and Basal Plate Derivatives in the Brain Stem 141
8.17 Adult Derivatives of the Forebrain, Midbrain, and Hindbrain 142
8.18 Cranial Nerve Primordia 143
8.19 Cranial Nerve Neuron Components 144
8.20 Development of Motor and Preganglionic Autonomic Nuclei in the Brain Stem and Spinal Cord 145
8.21 Development of the Eye and Orbit 146
8.22 Development of the Ear 147
8.23 Development of the Pituitary Gland 148
8.24 Development of the Ventricles 149
8.25 Development of the Fourth Ventricle 150
8.26 Neural Tube Defects 151
8.27 Defects of the Brain and Skull 152
II Regional Neuroscience 153
9 Peripheral Nervous System 155
Introduction and Basic Organization 156
9.1 Schematic of the Spinal Cord with Sensory, Motor, and Autonomic Components of Peripheral Nerves 156
9.2 Anatomy of a Peripheral Nerve 157
9.3 Nerve Compression and Pressure Gradients 158
9.4 Peripheral Nerve Injury and Degeneration in a Compression Neuropathy 159
9.5 Relationship of Spinal Nerve Roots to Vertebrae 160
9.6 Lumbar Disc Herniation: L4–L5 and L5–S1 161
9.7 Sensory Channels: Reflex and Cerebellar 162
9.8 Sensory Channels: Lemniscal 163
9.9 Motor Channels: Basic Organization of Lower and Upper Motor Neurons 164
9.10 Autonomic Channels 165
9.11 Cutaneous Receptors 166
9.12 Pacinian Corpuscles 167
9.13 Interoceptors 168
9.14 Skin and Its Nerves 169
9.15 The Neuromuscular Junction and Neurotransmission 170
9.16 Physiology of the Neuromuscular Junction 171
9.17 Major Structures and Proteins in the Normal Neuromuscular Junction 172
9.18 Neuroeffector Junctions 173
Somatic Nervous System 174
9.19 Dermatomal Distribution 174
9.20 Cutaneous Distribution of Peripheral Nerves 175
9.21 Cutaneous Nerves of the Head and Neck 176
9.22 Cervical Plexus in Situ 177
9.23 Cervical Plexus 178
9.24 Phrenic Nerve 179
9.25 Thoracic Nerves 180
9.26 Brachial Plexus 181
9.27 Dermatomes of the Upper Limb 182
9.28 Cervical Disc Herniation 183
9.29 Cutaneous Innervation of the Upper Limb 184
9.30 The Scapular, Axillary, and Radial Nerves Above the Elbow 185
9.31 Radial Nerve in the Forearm 186
9.32 Musculocutaneous Nerve 187
9.33 Median Nerve 188
9.34 Carpal Tunnel Syndrome 189
9.35 Ulnar Nerve 190
9.36 Lumbar Plexus 191
9.37 Sacral and Coccygeal Plexuses 192
9.38 Femoral and Lateral Femoral Cutaneous Nerves 193
9.39 Obturator Nerve 194
9.40 Sciatic and Posterior Femoral Cutaneous Nerves 195
9.41 Tibial Nerve 196
9.42 Common Peroneal Nerve 197
Autonomic Nervous System 198
9.43 General Schema 198
9.44 Autonomic Innervation of the Immune System and Metabolic Organs 199
9.45 Reflex Pathways 200
9.46 Cholinergic and Adrenergic Synapses 201
9.47 Schematic of Cholinergic and Adrenergic Distribution to Motor and Autonomic Structures 202
9.48 Autonomic Distribution to the Head and Neck: Medial View 203
9.49 Autonomic Distribution to the Head and Neck: Lateral View 204
9.50 Schematic of Autonomic Distribution to the Head and Neck 205
9.51 Autonomic Distribution to the Eye 206
9.52 Autonomic Innervation of the Nasal Cavity 207
9.53 Schematic of the Pterygopalatine and Submandibular Ganglia 208
9.54 Schematic of the otic Ganglion 209
9.55 Innervation of the Limbs 210
9.56 Thoracic Sympathetic Chain and Splanchnic Nerves 211
9.57 Innervation of the Tracheobronchial Tree 212
9.58 Innervation of the Heart 213
9.59 Abdominal Nerves and Ganglia 214
9.60 Nerves of the Esophagus 215
9.61 Innervation of the Stomach and Proximal Duodenum 216
9.62 Nerves of the Stomach and Duodenum 217
9.63 Innervation of the Small and Large Intestines 218
9.64 Nerves of the Small Intestine 219
9.65 Nerves of the Large Intestine 220
9.66 Enteric Nervous System: Longitudinal View 221
9.67 Enteric Nervous System: Cross-Sectional View 222
9.68 Autonomic Innervation of the Liver and Biliary Tract 223
9.69 Autonomic Innervation of the Pancreas 224
9.70 Schematic of Innervation of the Adrenal Gland 225
9.71 Innervation of the Adrenal Gland 226
9.72 Autonomic Pelvic Nerves and Ganglia 227
9.73 Nerves of the Kidneys, Ureters, and Urinary Bladder 228
9.74 Innervation of the Kidneys and Upper Ureter 229
9.75 Innervation of the Urinary Bladder and Lower Ureter 230
9.76 Innervation of the Male Reproductive Organs 231
9.77 Innervation of the Female Reproductive Organs 232
10 Spinal Cord 233
10.1 Cytoarchitecture of the Spinal Cord Gray Matter 234
10.2 Spinal Cord Levels: Cervical, Thoracic, Lumbar, and Sacral 235
10.3 Spinal Cord Levels: Cervical, Thoracic, Lumbar, and Sacral (continued) 236
10.4 Spinal Cord Levels: Cervical, Thoracic, Lumbar, and Sacral (continued) 237
10.5 Spinal Cord Levels: Cervical, Thoracic, Lumbar, and Sacral (continued) 238
10.6 Spinal Cord Histological Cross Sections 239
10.7 Spinal Cord Histological Cross Sections (Continued) 240
10.8 Spinal Cord Imaging 241
10.9 Spinal Cord Syndromes 242
10.10 Spinal Cord Lower Motor Neuron Organization and Control 243
10.11 Spinal Somatic Reflex Pathways 244
10.12 Muscle and Joint Receptors and Muscle Spindles 245
10.13 The Muscle Stretch Reflex and Its Central Control via Gamma Motor Neurons 246
11 Brain Stem and Cerebellum 247
Brain Stem Cross-Sectional Anatomy 248
11.1 Brain Stem Cross-Sectional Anatomy: Section 1 248
11.2 Brain Stem Cross-Sectional Anatomy: Section 2 249
11.3 Brain Stem Cross-Sectional Anatomy: Section 3 250
11.4 Brain Stem Cross-Sectional Anatomy: Section 4 251
11.5 Brain Stem Cross-Sectional Anatomy: Section 5 252
11.6 Brain Stem Cross-Sectional Anatomy: Section 6 253
11.7 Brain Stem Cross-Sectional Anatomy: Section 7 254
11.8 Brain Stem Cross-Sectional Anatomy: Section 8 255
11.9 Brain Stem Cross-Sectional Anatomy: Section 9 256
11.10 Brain Stem Cross-Sectional Anatomy: Section 10 257
11.11 Brain Stem Cross-Sectional Anatomy: Section 11 258
11.12 Brain Stem Cross-Sectional Anatomy: Section 12 259
11.13 Brain Stem Cross-Sectional Anatomy: Section 13 260
11.14 Brain Stem Cross-Sectional Anatomy: Section 14 261
11.15 Brain Stem Arterial Syndromes 262
Cranial Nerves and Cranial Nerve Nuclei 263
11.16 Cranial Nerves: Schematic of Distribution of Sensory, Motor, and Autonomic Fibers 263
11.17 Cranial Nerves and Their Nuclei: Schematic View From Above 265
11.18 Cranial Nerves and Their Nuclei: Schematic Lateral View 266
11.19 Nerves of the Orbit 267
11.20 Nerves of the Orbit (Continued) 268
11.21 Extraocular Nerves (III, IV, and VI) and the Ciliary Ganglion: View in Relation to the Eye 269
11.22 Trigeminal Nerve (V) 271
11.23 Innervation of the Teeth 272
11.24 Facial Nerve (VII) 273
11.25 Facial Nerve Branches and the Parotid Gland 274
11.26 Vestibulocochlear Nerve (VIII) 275
11.27 Glossopharyngeal Nerve (IX) 276
11.28 Accessory Nerve (XI) 277
11.29 Vagus Nerve (X) 279
11.30 Hypoglossal Nerve (XII) 280
Reticular Formation 281
11.31 Reticular Formation: General Pattern of Nuclei in the Brain Stem 281
11.32 Reticular Formation: Nuclei and Areas in the Brain Stem and Diencephalon 282
11.33 Major Afferent and Efferent Connections to the Reticular Formation 283
11.34 Sleep-Wakefulness Control 284
Cerebellum 285
11.35 Cerebellar Organization: Lobes and Regions 285
11.36 Cerebellar Anatomy: Lobules 286
11.37 Cerebellar Anatomy: Deep Nuclei and Cerebellar Peduncles 287
12 Diencephalon 289
12.1 Thalamic Anatomy and Interconnections with the Cerebral Cortex 290
12.2 Hypothalamus and Pituitary Gland 291
12.3 Hypothalamic Nuclei 293
13 Telencephalon 295
13.1A Axial (Horizontal) Sections Through the Forebrain: Level 1—Mid Pons 296
13.1B Axial (Horizontal) Sections Through the Forebrain: Level 1—Mid Pons 297
13.2A Axial (Horizontal) Sections Through the Forebrain: Level 2—Rostral Pons 298
13.2B Axial (Horizontal) Sections Through the Forebrain: Level 2—Rostral Pons (Continued) 299
13.3A Axial (Horizontal) Sections Through the Forebrain: Level 3—Midbrain 300
13.3B Axial (Horizontal) Sections Through the Forebrain: Level 3—Midbrain (Continued) 301
13.4A Axial (Horizontal) Sections Through the Forebrain: Level 4—Rostral Midbrain and Hypothalamus 302
13.4B Axial (Horizontal) Sections Through the Forebrain: Level 4—Rostral Midbrain and Hypothalamus (Continued) 303
13.5A Axial (Horizontal) Sections Through the Forebrain: Level 5—Anterior Commissure and Caudal Thalamus 304
13.5B Axial (Horizontal) Sections Through the Forebrain: Level 5—Anterior Commissure and Caudal Thalamus (Continued) 305
13.6A Axial (Horizontal) Sections Through the Forebrain: Level 6—Head of Caudate and Midthalamus 306
13.6B Axial (Horizontal) Sections Through the Forebrain: Level 6—Head of Caudate and Midthalamus (Continued) 307
13.7A Axial (Horizontal) Sections Through the Forebrain: Level 7—Basal Ganglia and Internal Capsule 308
13.7B Axial (Horizontal) Sections Through the Forebrain: Level 7—Basal Ganglia and Internal Capsule (Continued) 309
13.8A Axial (Horizontal) Sections Through the Forebrain: Level 8—Dorsal Caudate, Splenium, and Genu of Corpus Callosum 310
13.8B Axial (Horizontal) Sections Through the Forebrain: Level 8—Dorsal Caudate, Splenium, and Genu of Corpus Callosum (Continued) 311
13.9A Axial (Horizontal) Sections Through the Forebrain: Level 9—Body of Corpus Callosum 312
13.9B Axial (Horizontal) Sections Through the Forebrain: Level 9—Body of Corpus Callosum (Continued) 313
13.10A Axial (Horizontal) Sections Through the Forebrain: Level 10—Centrum Semiovale 314
13.10B Axial (Horizontal) Sections Through the Forebrain: Level 10—Centrum Semiovale (Continued) 315
13.11A Coronal Sections Through the Forebrain: Level 1—Genu of Corpus Callosum 316
13.11B Coronal Sections Through the Forebrain: Level 1—Genu of Corpus Callosum (Continued) 317
13.12A Coronal Sections Through the Forebrain: Level 2—Head of Caudate Nucleus/Nucleus Accumbens 318
13.12B Coronal Sections Through the Forebrain: Level 2—Head of Caudate Nucleus/Nucleus Accumbens (Continued) 319
13.13A Coronal Sections Through the Forebrain: Level 3—Anterior Commissure/Columns of Fornix 320
13.13B Coronal Sections Through the Forebrain: Level 3—Anterior Commissure/Columns of Fornix (Continued) 321
13.14A Coronal Sections Through the Forebrain: Level 4—Amygdala, Anterior Limb of Internal Capsule 322
13.14B Coronal Sections Through the Forebrain: Level 4—Amygdala, Anterior Limb of Internal Capsule (Continued) 323
13.15A Coronal Sections Through the Forebrain: Level 5—Mammillary Body 324
13.15B Coronal Sections Through the Forebrain: Level 5—Mammillary Body (Continued) 325
13.16A Coronal Sections Through the Forebrain: Level 6—Mammillothalamic Tract/Substantia Nigra, Rostral Hippocampus 326
13.16B Coronal Sections Through the Forebrain: Level 6—Mammillothalamic Tract/Substantia Nigra, Rostral Hippocampus (Continued) 327
13.17A Coronal Sections Through the Forebrain: Level 7—Midthalamus 328
13.17B Coronal Sections Through the Forebrain: Level 7—Midthalamus (Continued) 329
13.18A Coronal Sections Through the Forebrain: Level 8—Geniculate Nuclei 330
13.18B Coronal Sections Through the Forebrain: Level 8—Geniculate Nuclei (Continued) 331
13.19A Coronal Sections Through the Forebrain: Level 9—Caudal Pulvinar and Superior Colliculus 332
13.19B Coronal Sections Through the Forebrain: Level 9—Caudal Pulvinar and Superior Colliculus (Continued) 333
13.20A Coronal Sections Through the Forebrain: Level 10—Splenium of Corpus Callosum 334
13.20B Coronal Sections Through the Forebrain: Level 10—Splenium of Corpus Callosum (Continued) 335
13.21 Layers of the Cerebral Cortex 336
13.22 Cortical Neuronal Cell Types 337
13.23 Vertical Columns: Functional Units of the Cerebral Cortex 338
13.24 Efferent Connections of the Cerebral Cortex 339
13.25 Neuronal Origins of Efferent Connections of the Cerebral Cortex 340
13.26 Cortical Association Pathways 341
13.27 Major Cortical Association Bundles 342
13.28 Color Imaging of Association Pathways 343
13.29 Color Imaging of Projection Pathways from the Cerebral Cortex 344
13.30 Functional Magnetic Resonance Imaging 345
13.31 Aphasias and Cortical Areas of Damage 346
13.32 Noradrenergic Pathways 347
13.33 Serotonergic Pathways 348
13.34 Dopaminergic Pathways 349
13.35 Central Cholinergic Pathways 350
13.36 Distribution of Pathology in the Brain in Alzheimer Disease 351
13.37 The Olfactory Nerve and Nerves of the Nose 352
III Systemic Neuroscience 353
14 Sensory Systems 355
Somatosensory Systems 356
14.1 Somatosensory Afferents to the Spinal Cord 356
14.2 Spinal Somatic Reflex Actions and Pathways 357
14.3 Somatosensory System: Spinocerebellar Pathways 358
14.4 Somatosensory System: The Dorsal Column System and Epicritic Modalities 359
14.5 Somatosensory System: The Spinothalamic and Spinoreticular Systems and Protopathic Modalities (CONTINUED) 361
14.6 Spinothalamic and Spinoreticular Nociceptive Processing in the Spinal Cord 362
14.7 Mechanisms of Neuropathic Pain and Sympathetically Maintained Pain 363
14.8 Descending Control of Ascending Somatosensory Systems 364
Trigeminal Sensory System 365
14.9 Trigeminal Sensory and Associated Sensory Systems 365
14.10 Pain-Sensitive Structures of the Head and Pain Referral 366
Sensory System for Taste 367
14.11 Anatomy of Taste Buds and Their Receptors 367
14.12 Taste Pathways 368
Auditory System 369
14.13 Peripheral Pathways for Sound Reception 369
14.14 Bony and Membranous Labyrinths 370
14.15 VIII Nerve Innervation of Hair Cells of the Organ of Corti 371
14.16 Cochlear Receptors 372
14.17 Afferent Auditory Pathways 373
14.18 Afferent Auditory Pathways (CONTINUED) 374
14.19 Centrifugal (Efferent) Auditory Pathways 375
Vestibular System 376
14.20 Vestibular Receptors 376
14.21 Vestibular Pathways 377
14.22 Nystagmus 378
Visual System 379
14.23 Anatomy of the Eye 379
14.24 Anterior and Posterior Chambers of the Eye 380
14.25 The Retina: Retinal Layers 381
14.26 The Retina: Photoreceptors 382
14.27 The Retina: Optic Nerve 383
14.28 Arteries and Veins of the Eye 384
14.29 Anatomy and Relationships of the Optic Chiasm 385
14.30 Visual Pathways: Retinal Projections to the Thalamus, Hypothalamus, and Brain Stem 386
14.31 Pupillary Light Reflex 387
14.32 Visual Pathway: The Retino-Geniculo-Calcarine Pathway 388
14.33 Visual Pathways in the Parietal and Temporal Lobes 389
14.34 Visual System Lesions 390
15 Motor Systems 391
Lower Motor Neurons 392
15.1 Alpha and Gamma Lower Motor Neurons 392
15.2 Distribution of Lower Motor Neurons in the Spinal Cord 393
15.3 Distribution of Lower Motor Neurons in the Brain Stem 394
Upper Motor Neurons 395
15.4 Cortical Efferent Pathways 395
15.5 Color Imaging of Cortical Efferent Pathways 396
15.6 Corticobulbar Tract 397
15.7 Corticospinal Tract 399
15.8 Corticospinal Tract Terminations in the Spinal Cord 400
15.9 Rubrospinal Tract 401
15.10 Vestibulospinal Tracts 403
15.11 Reticulospinal and Corticoreticular Pathways 404
15.12 Tectospinal Tract and Interstitiospinal Tract 405
15.13 Spinal Cord Terminations of Major Descending Upper Motor Neuron Tracts 406
15.14 Central Control of Eye Movements 407
15.15 Central Control of Respiration 408
Cerebellum 409
15.16 Functional Subdivisions of the Cerebellum 409
15.17 Cerebellar Neuronal Circuitry 410
15.18 Circuit Diagrams of Afferent Connections in the Cerebellum 411
15.19 Afferent Pathways to the Cerebellum 412
15.20 Cerebellar Efferent Pathways 413
15.21 Cerebellovestibular and Vestibulocerebellar Pathways 414
15.22 Schematic Diagrams of Efferent Pathways From the Cerebellum to Upper Motor Neuron Systems 415
Basal Ganglia 416
15.23 Connections of the Basal Ganglia 416
15.24 Simplified Schematic of Basal Ganglia Circuitry and Neurochemistry 417
15.25 Parallel Loops of Circuitry Through the Basal Ganglia 418
15.26 Connections of Nucleus Accumbens 419
16 Autonomic-Hypothalamic-Limbic Systems 421
Autonomic Nervous System 423
16.1 General Organization of the Autonomic Nervous System 423
Hypothalamus and Pituitary 424
16.2 General Anatomy of the Hypothalamus 424
16.3 Sections Through the Hypothalamus: Preoptic and Supraoptic Zones 425
16.4 Sections Through the Hypothalamus: Tuberal Zone 426
16.5 Sections Through the Hypothalamus: Mammillary Zone 427
16.6 Schematic Reconstruction of the Hypothalamus 428
16.7 Forebrain Regions Associated with the Hypothalamus 429
16.8 Afferent and Efferent Pathways Associated with the Hypothalamus 430
16.9 Schematic Diagram of Major Hypothalamic Afferent Pathways 431
16.10 Schematic Diagram of Major Hypothalamic Efferent Pathways 432
16.11 Summary of General Hypothalamic Connections 433
16.12 Paraventricular Nucleus of the Hypothalamus: Regulation of Pituitary Neurohormonal Outflow, Autonomic Preganglionic Outflow, and Limbic Activity 434
16.13 Mechanisms of Cytokine Influences on the Hypothalamus and Other Brain Regions and on Behavior 435
16.14 Circumventricular Organs 436
16.15 The Hypophyseal Portal Vasculature 437
16.16 Regulation of Anterior Pituitary Hormone Secretion 439
16.17 Posterior Pituitary (Neurohypophyseal) Hormones: Oxytocin and Vasopressin 440
16.18 Vasopressin (Antidiuretic Hormone) Regulation of Water Balance and Fluid Osmolality 441
16.19 The Hypothalamus and Thermoregulation 442
16.20 Hypothalamic Regulation of Cardiac Function 443
16.21 Short-Term Regulation of Blood Pressure 444
16.22 Long-Term Regulation of Blood Pressure 445
16.23 Neural Control of Appetite and Hunger 446
16.24 Signaling Systems Involved in Regulation of Food Intake, Body Weight, and Metabolism 447
16.25 Neural and Neuroendocrine Roles in the Fight-or-Flight Response 448
16.26 Neuroimmunomodulation 449
Limbic System 450
16.27 Anatomy of the Limbic Forebrain 450
16.28 Hippocampal Formation: General Anatomy 451
16.29 Neuronal Connections in the Hippocampal Formation 452
16.30 Major Afferent and Efferent Connections of the Hippocampal Formation 453
16.31 Afferent and Efferent Connections of the Entorhinal Cortex 454
16.32 Major Afferent Connections of the Amygdala 455
16.33 Major Efferent Connections of the Amygdala 456
16.34 Summary of Major Afferents, Efferents, and Interconnections of the Amygdala 457
16.35 Major Afferent and Efferent Connections of the Septal Nuclei 458
16.36 Major Connections of the Cingulate Cortex 459
Olfactory System 460
16.37 Olfactory Receptors 460
16.38 Olfactory Pathways 461
Index 463
A 463
B 464
C 465
D 467
E 467
F 467
G 468
H 468
I 469
J 469
K 469
L 469
M 470
N 471
O 472
P 472
Q 473
R 473
S 474
T 476
U 476
V 476
W 477