Additional Information
Book Details
Abstract
The second edition of Dorfman and Czerniak's Bone Tumors brings together the latest data available on bone tumor pathology, making it the most comprehensive and encyclopedic reference on the epidemiology, clinical, pathologic, and molecular aspects of bone tumors. Now offered in full color and featuring updated imaging throughout, this one-of-a-kind resource provides a highly visual review of every disorder — from the common to the rare.
- Features comprehensive coverage of bone tumor pathology based on pathologic and clinical data on 11,500 benign and malignant bone tumors from patients treated at the MD Anderson Cancer Center.
- High-quality full-color images located throughout the text.
- Completely up-to-date molecular and genetic information is based on the most current genomic databases.
- Four brand-new chapters cover Radiographic Imaging of Bone Tumors; Hematopoetic Tumors; Neural Tumors; and Metastic Tumors of Bone.
- Includes information on molecular and genetic aspects of bone tumors from the UCSC Genome Browser, the Catologue of Somatic Mutations in Cancer, and the GeneCards Database of human genes.
- Features comprehensive data from nearly 30,000 benign and malignant primary bone tumors and tumor-like lesions from different sources, including over 8,400 malignant bone tumors from the National Cancer Institute’s Surveillance, Epidemiology and End Result project.
- Provides an enhanced visual understanding with updated radiographic imaging and new full-color, high-quality photomicrographs.
- Updated Molecular and Epidemiologic diagrams added to all new chapters.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Expert Consult page | IFC1 | ||
| Dorfman and Czerniak's Bone Tumors | i | ||
| Copyright Page | iv | ||
| Dedication | v | ||
| Preface | vi | ||
| Foreword | viii | ||
| Preface to the First Edition | x | ||
| Contributors | xii | ||
| Table Of Contents | xiii | ||
| 1 General Considerations | 1 | ||
| Chapter Outline | 1 | ||
| Introduction | 1 | ||
| Morphology of Normal Bone | 3 | ||
| Topographic Features | 3 | ||
| Bone | 3 | ||
| Cartilage | 4 | ||
| Extracellular Matrix | 4 | ||
| Collagen | 7 | ||
| Proteoglycans | 7 | ||
| Bone Mineral | 8 | ||
| Cells | 8 | ||
| Osteoblasts | 8 | ||
| Osteocytes | 8 | ||
| Osteoclasts | 8 | ||
| Chondroblasts | 10 | ||
| Chondrocytes | 12 | ||
| Development of Bone | 12 | ||
| Processing of Bone Specimens | 12 | ||
| Intraoperative Diagnostic Procedures | 12 | ||
| Biopsy and Curettage | 14 | ||
| Resection and Amputation Specimens | 16 | ||
| Staging, Grading, and Reporting of Bone Tumors | 17 | ||
| Staging Systems | 17 | ||
| Grading Systems | 23 | ||
| Reporting of Bone Tumors | 24 | ||
| General Epidemiology of Bone Tumors | 24 | ||
| Special Techniques | 28 | ||
| Special Stains | 30 | ||
| Periodic Acid-Schiff Stain | 30 | ||
| Mucins | 30 | ||
| Trichrome Stain | 30 | ||
| Stains for Microorganisms | 30 | ||
| Argentaffin and Argyrophilic Stains | 32 | ||
| Reticulin Stain | 32 | ||
| Amyloid Stain | 32 | ||
| Hemosiderin | 32 | ||
| Melanin Stain | 32 | ||
| Calcium Stain | 32 | ||
| Enzyme Histochemistry | 32 | ||
| Electron Microscopy | 32 | ||
| Cytometry and Histomorphometry | 33 | ||
| Flow Cytometry | 34 | ||
| Image Analysis | 36 | ||
| Histomorphometry | 37 | ||
| Immunohistochemistry | 37 | ||
| Intermediate Filaments | 39 | ||
| Epithelial Markers | 41 | ||
| Muscle Markers | 41 | ||
| Vascular Markers | 45 | ||
| Neural Markers | 45 | ||
| Miscellaneous Antigens | 46 | ||
| Lineage-Specific Transcription Factors | 46 | ||
| Cytogenetics | 47 | ||
| References | 49 | ||
| Introduction | 49 | ||
| Morphology of Normal Bone | 49 | ||
| Processing of Bone Specimens | 50 | ||
| Staging, Grading, and Reporting of Bone Tumors | 50 | ||
| General Epidemiology of Bone Tumors | 51 | ||
| Special Stains | 52 | ||
| Electron Microscopy | 52 | ||
| Cytometry and Histomorphometry | 53 | ||
| Immunohistochemistry | 53 | ||
| Cytogenetics | 55 | ||
| 2 Clinical Considerations and Imaging of Bone Tumors | 57 | ||
| Chapter Outline | 57 | ||
| Introduction | 57 | ||
| Clinical Considerations | 57 | ||
| Age | 59 | ||
| Location | 59 | ||
| Initial Staging | 59 | ||
| Diagnostic Principles | 59 | ||
| Imaging Modalities | 62 | ||
| Imaging Characterization of Primary Bone Tumors | 63 | ||
| Response to Therapy | 82 | ||
| Primary Bone Tumors | 82 | ||
| Bone Metastases | 85 | ||
| Restaging and Oncologic Surveillance | 88 | ||
| Local Recurrence | 88 | ||
| Distant Metastases | 89 | ||
| Conclusion | 93 | ||
| References | 93 | ||
| 3 Molecular Biology of Bone Tumors | 96 | ||
| Chapter Outline | 96 | ||
| Molecular Techniques | 96 | ||
| Hybridization Techniques | 96 | ||
| Southern Blotting | 97 | ||
| Northern Blotting | 97 | ||
| Western Blotting | 97 | ||
| Polymerase Chain Reaction | 98 | ||
| Genomic Sequencing | 99 | ||
| High Throughput Genomic Profiling | 100 | ||
| Molecular Biology of Bone Formation | 101 | ||
| Osteoblastic Lineage | 103 | ||
| Chondroblastic Lineage | 103 | ||
| Osteoclastic Lineage | 106 | ||
| Mechanisms of Malignant Transformation | 106 | ||
| RAS Genes | 108 | ||
| TP53 Gene | 110 | ||
| RB Gene | 112 | ||
| DNA Helicases | 114 | ||
| Chromosomal Translocations | 114 | ||
| Karyotyping | 119 | ||
| Fluorescence In Situ Hybridization | 119 | ||
| Sequencing of Fusion Transcripts | 124 | ||
| Chromothripsis | 125 | ||
| Cell-Cycle and Mitotic Regulation | 125 | ||
| Molecular Concepts of Bone Neoplasia | 131 | ||
| Osteosarcoma | 131 | ||
| Chondrosarcoma | 132 | ||
| Chordoma | 133 | ||
| Ewing’s Sarcoma | 133 | ||
| References | 135 | ||
| Molecular Techniques | 135 | ||
| Molecular Biology of Bone Formation | 136 | ||
| Mechanisms of Malignant Transformation | 138 | ||
| Cell-Cycle and Mitotic Regulation | 140 | ||
| Molecular Concepts of Bone Neoplasia | 141 | ||
| 4 Benign Osteoblastic Tumors | 144 | ||
| Chapter Outline | 144 | ||
| Osteoid Osteoma | 145 | ||
| Definition | 145 | ||
| Incidence and Location | 145 | ||
| Clinical Symptoms | 145 | ||
| Radiographic Imaging | 147 | ||
| Gross Findings | 147 | ||
| Microscopic Findings | 147 | ||
| Differential Diagnosis | 147 | ||
| Treatment and Behavior | 160 | ||
| Osteoid Osteoma in Different Anatomic Sites | 160 | ||
| Osteoid Osteoma of Long Tubular Bones | 160 | ||
| Osteoid Osteoma of Small Bones of Hands and Feet | 163 | ||
| Osteoid Osteoma of Vertebral Column | 163 | ||
| Juxtaarticular Osteoid Osteoma | 163 | ||
| Subperiosteal Osteoid Osteoma | 163 | ||
| Personal Comments | 167 | ||
| Benign Osteoblastoma | 167 | ||
| Definition | 167 | ||
| Incidence and Location | 167 | ||
| Radiographic Imaging | 167 | ||
| Gross Findings | 174 | ||
| Microscopic Findings | 174 | ||
| Differential Diagnosis | 174 | ||
| Treatment and Behavior | 174 | ||
| Aggressive Osteoblastoma | 181 | ||
| Definition | 181 | ||
| Incidence and Location | 181 | ||
| Radiographic Imaging | 181 | ||
| Gross Findings | 181 | ||
| Microscopic Findings | 181 | ||
| Differential Diagnosis | 189 | ||
| Personal Comments | 189 | ||
| References | 197 | ||
| 5 Osteosarcoma | 200 | ||
| Chapter Outline | 200 | ||
| Intramedullary Osteosarcoma | 200 | ||
| Conventional Osteosarcoma | 200 | ||
| Definition | 200 | ||
| Incidence and Location | 200 | ||
| Clinical Symptoms | 201 | ||
| Radiographic Imaging | 201 | ||
| Gross Findings | 215 | ||
| Microscopic Findings | 215 | ||
| Osteosarcoma with Unique Microscopic Features. | 242 | ||
| Pathologic Assessment of Preoperative Chemotherapy Effect | 246 | ||
| Special Techniques | 251 | ||
| Differential Diagnosis | 259 | ||
| Treatment and Behavior | 261 | ||
| Conventional Osteosarcoma in Different Anatomic Sites | 262 | ||
| Osteosarcoma of Appendicular Skeleton. | 262 | ||
| Osteosarcoma of Craniofacial Bones. | 262 | ||
| Osteosarcoma of Flat Bones and Ribs. | 271 | ||
| Osteosarcoma of Vertebral Column. | 271 | ||
| Personal Comments | 271 | ||
| Telangiectatic Osteosarcoma | 275 | ||
| Definition | 275 | ||
| Incidence and Location | 275 | ||
| Clinical Symptoms | 275 | ||
| Radiographic Imaging | 275 | ||
| Gross Findings | 275 | ||
| Microscopic Findings | 275 | ||
| Special Techniques | 276 | ||
| Differential Diagnosis | 291 | ||
| Clinical Behavior | 291 | ||
| Well-differentiated Intramedullary Osteosarcoma | 291 | ||
| Definition | 291 | ||
| Incidence and Location | 291 | ||
| Clinical Symptoms | 291 | ||
| Radiographic Imaging | 291 | ||
| Gross Findings | 292 | ||
| Microscopic Findings | 292 | ||
| Differential Diagnosis | 297 | ||
| Treatment and Behavior | 297 | ||
| Osteosarcoma Associated with Specific Clinical Syndromes | 304 | ||
| Secondary Osteosarcoma | 304 | ||
| Surface Osteosarcoma | 309 | ||
| Parosteal Osteosarcoma | 309 | ||
| Definition | 309 | ||
| Incidence and Location | 309 | ||
| Clinical Symptoms | 310 | ||
| Radiographic Imaging | 310 | ||
| Gross Findings | 311 | ||
| Microscopic Findings | 311 | ||
| Differential Diagnosis | 322 | ||
| Treatment and Behavior | 328 | ||
| Periosteal Osteosarcoma | 328 | ||
| Definition | 328 | ||
| Incidence and Location | 328 | ||
| Clinical Symptoms | 328 | ||
| Radiographic Imaging | 328 | ||
| Gross Findings | 328 | ||
| Microscopic Findings | 328 | ||
| Differential Diagnosis | 329 | ||
| Treatment and Behavior | 331 | ||
| High-grade Surface Osteosarcoma | 331 | ||
| Definition | 331 | ||
| Incidence and Location | 331 | ||
| Clinical Symptoms | 331 | ||
| Radiographic Imaging | 331 | ||
| Gross Findings | 331 | ||
| Microscopic Findings | 332 | ||
| Differential Diagnosis | 332 | ||
| Treatment and Behavior | 342 | ||
| Intracortical Osteosarcoma | 342 | ||
| Definition | 342 | ||
| Incidence and Location | 342 | ||
| Clinical Symptoms | 342 | ||
| Radiographic Imaging | 342 | ||
| 6 Benign Cartilage Lesions | 356 | ||
| Chapter Outline | 356 | ||
| Enchondroma | 356 | ||
| Definition | 356 | ||
| Incidence and Location | 356 | ||
| Clinical Symptoms | 357 | ||
| Radiographic Imaging | 357 | ||
| Gross Findings | 364 | ||
| Microscopic Findings | 364 | ||
| Special Techniques | 364 | ||
| Differential Diagnosis | 376 | ||
| Enchondroma in Different Anatomic Sites | 376 | ||
| Enchondroma of the Small Bones of the Hands and Feet. | 376 | ||
| Enchondroma of Long Tubular Bones. | 376 | ||
| Enchondroma of Trunk Bones. | 376 | ||
| Treatment and Behavior | 377 | ||
| Personal Comments | 377 | ||
| Periosteal Chondroma | 377 | ||
| Definition | 377 | ||
| Incidence and Location | 377 | ||
| Clinical Symptoms | 377 | ||
| Radiographic Imaging | 377 | ||
| Gross Findings | 378 | ||
| Microscopic Findings | 378 | ||
| Special Techniques | 386 | ||
| Differential Diagnosis | 386 | ||
| Treatment and Behavior | 386 | ||
| Enchondromatosis | 386 | ||
| Ollier’s Disease | 386 | ||
| Definition | 386 | ||
| Incidence and Location | 386 | ||
| Clinical Symptoms | 387 | ||
| Radiographic Imaging | 388 | ||
| Gross Findings | 395 | ||
| Microscopic Findings | 395 | ||
| Special Techniques | 395 | ||
| Differential Diagnosis | 395 | ||
| Treatment and Behavior | 396 | ||
| Maffucci’s Syndrome | 396 | ||
| Malignant Transformation in Enchondromatosis | 400 | ||
| Chondroblastoma | 400 | ||
| Definition | 400 | ||
| Incidence and Location | 400 | ||
| Clinical Symptoms | 400 | ||
| Radiographic Imaging | 405 | ||
| Gross Findings | 405 | ||
| Microscopic Findings | 416 | ||
| Special Techniques | 416 | ||
| Differential Diagnosis | 425 | ||
| Treatment and Behavior | 425 | ||
| Personal Comments | 425 | ||
| Chondromyxoid Fibroma | 425 | ||
| Definition | 425 | ||
| Incidence and Location | 426 | ||
| Clinical Symptoms | 426 | ||
| Radiographic Imaging | 426 | ||
| Gross Findings | 430 | ||
| Microscopic Findings | 430 | ||
| Special Techniques | 430 | ||
| Differential Diagnosis | 438 | ||
| Treatment and Behavior | 438 | ||
| Personal Comments | 438 | ||
| Osteochondroma | 438 | ||
| Solitary Osteochondroma (Osteocartilaginous Exostosis) | 441 | ||
| Definition | 441 | ||
| Incidence and Location | 441 | ||
| Clinical Symptoms | 441 | ||
| Radiographic Imaging | 441 | ||
| Gross Findings | 442 | ||
| Microscopic Findings | 450 | ||
| Differential Diagnosis | 450 | ||
| Treatment and Behavior | 450 | ||
| Multiple Hereditary Exostoses | 450 | ||
| Malignant Transformation in Osteochondroma | 458 | ||
| References | 467 | ||
| Enchondroma | 467 | ||
| Periosteal Chondroma | 467 | ||
| Enchondromatosis | 468 | ||
| Ollier’s Disease | 468 | ||
| Maffucci’s Syndrome | 469 | ||
| Chondroblastoma | 469 | ||
| Chondromyxoid Fibroma | 471 | ||
| Osteochondroma | 472 | ||
| 7 Malignant Cartilage Tumors | 474 | ||
| Chapter Outline | 474 | ||
| Intramedullary Chondrosarcoma | 474 | ||
| Conventional Chondrosarcoma | 474 | ||
| Definition | 474 | ||
| Incidence and Location | 475 | ||
| Clinical Symptoms | 478 | ||
| Radiographic Imaging | 478 | ||
| Gross Findings | 478 | ||
| Microscopic Findings | 485 | ||
| Grade 1 Chondrosarcoma. | 485 | ||
| Grade 2 Chondrosarcoma. | 494 | ||
| Grade 3 Chondrosarcoma. | 494 | ||
| Special Techniques | 494 | ||
| Differential Diagnosis | 501 | ||
| Conventional Chondrosarcoma in Different Anatomic Sites | 502 | ||
| Chondrosarcoma of Long Tubular Bones. | 502 | ||
| Chondrosarcoma of Flat Bones. | 502 | ||
| Chondrosarcoma of Ribs and Sternum. | 502 | ||
| Chondrosarcoma of Craniofacial Bones. | 502 | ||
| Chondrosarcoma of Vertebral Column and Sacrum. | 506 | ||
| Chondrosarcoma of Small Bones of Hands and Feet. | 506 | ||
| Treatment and Behavior | 506 | ||
| Personal Comments | 506 | ||
| Dedifferentiated Chondrosarcoma | 510 | ||
| Definition | 510 | ||
| Incidence and Location | 510 | ||
| Clinical Symptoms | 510 | ||
| Radiographic Imaging | 511 | ||
| Gross Findings | 511 | ||
| Microscopic Findings | 516 | ||
| Special Techniques | 516 | ||
| Differential Diagnosis | 525 | ||
| Treatment and Behavior | 525 | ||
| Clear Cell Chondrosarcoma | 525 | ||
| Definition | 525 | ||
| Incidence and Location | 525 | ||
| Clinical Symptoms | 525 | ||
| Radiographic Imaging | 525 | ||
| Gross Findings | 526 | ||
| Microscopic Findings | 526 | ||
| Special Techniques | 535 | ||
| Differential Diagnosis | 535 | ||
| Treatment and Behavior | 535 | ||
| Mesenchymal Chondrosarcoma | 535 | ||
| Definition | 535 | ||
| Incidence and Location | 537 | ||
| Clinical Symptoms | 537 | ||
| Radiographic Imaging | 537 | ||
| Gross Findings | 541 | ||
| Microscopic Findings | 541 | ||
| Special Techniques | 541 | ||
| Differential Diagnosis | 559 | ||
| Treatment and Behavior | 559 | ||
| Juxtacortical Chondrosarcoma | 560 | ||
| Definition | 560 | ||
| Incidence and Location | 560 | ||
| Clinical Symptoms | 560 | ||
| Radiographic Imaging | 560 | ||
| Gross Findings | 560 | ||
| Microscopic Findings | 560 | ||
| Differential Diagnosis | 560 | ||
| Secondary Chondrosarcomas | 560 | ||
| References | 565 | ||
| Intramedullary Chondrosarcoma | 565 | ||
| Dedifferentiated Chondrosarcoma | 567 | ||
| Clear Cell Chondrosarcoma | 568 | ||
| Mesenchymal Chondrosarcoma | 568 | ||
| Juxtacortical Chondrosarcoma | 569 | ||
| 8 Fibrous Dysplasia and Related Lesions | 570 | ||
| Chapter Outline | 570 | ||
| Fibrous Dysplasia | 570 | ||
| Definition | 572 | ||
| Clinical Symptoms | 572 | ||
| Radiographic Imaging | 578 | ||
| Gross Findings | 578 | ||
| Microscopic Findings | 578 | ||
| Differential Diagnosis | 591 | ||
| Treatment and Behavior | 591 | ||
| Fibrous Dysplasia in Different Anatomic Sites | 601 | ||
| Fibrous Dysplasia of Craniofacial Bones. | 601 | ||
| Fibrous Dysplasia of Ribs. | 601 | ||
| Fibrous Dysplasia of Extremity Bones. | 606 | ||
| Fibrous Dysplasia of Flat Bones. | 606 | ||
| Personal Comments | 606 | ||
| Fibrocartilaginous Dysplasia | 606 | ||
| Incidence and Location | 606 | ||
| Clinical Symptoms | 606 | ||
| Radiographic Imaging | 607 | ||
| Gross Findings | 607 | ||
| Microscopic Findings | 607 | ||
| Differential Diagnosis | 607 | ||
| Clinical Behavior | 614 | ||
| References | 614 | ||
| Fibrous Dysplasia | 614 | ||
| Fibrocartilaginous Dysplasia | 616 | ||
| 9 Fibrous and Fibrohistiocytic Lesions | 617 | ||
| Chapter Outline | 617 | ||
| Nonossifying Fibroma (Fibrous Cortical Defect) | 617 | ||
| Definition | 617 | ||
| Incidence and Location | 617 | ||
| Clinical Symptoms | 617 | ||
| Radiographic Imaging | 617 | ||
| Gross Findings | 618 | ||
| Microscopic Findings | 618 | ||
| Special Techniques | 629 | ||
| Differential Diagnosis | 629 | ||
| Treatment and Behavior | 629 | ||
| Personal Comments | 629 | ||
| Multifocal Nonossifying Fibroma Associated with Clinical Syndromes | 634 | ||
| Benign Fibrous Histiocytoma | 634 | ||
| Definition | 634 | ||
| Incidence and Location | 634 | ||
| Clinical Symptoms | 634 | ||
| Radiographic Imaging | 634 | ||
| Gross Findings | 634 | ||
| Microscopic Findings | 634 | ||
| Differential Diagnosis | 638 | ||
| Treatment and Behavior | 638 | ||
| Personal Comments | 641 | ||
| Fibromyxoma | 641 | ||
| Angiomatoid Fibrous Histiocytoma | 641 | ||
| Clinical Symptoms | 641 | ||
| Radiographic Imaging | 641 | ||
| Gross Findings | 641 | ||
| Microscopic Findings | 641 | ||
| Special Techniques | 641 | ||
| Treatment and Behavior | 647 | ||
| Skeletal Fibromatoses | 647 | ||
| Desmoplastic Fibroma | 647 | ||
| Definition | 647 | ||
| Incidence and Location | 647 | ||
| Clinical Symptoms | 647 | ||
| Radiographic Imaging | 649 | ||
| Gross Findings | 649 | ||
| Microscopic Findings | 649 | ||
| Special Techniques | 651 | ||
| Differential Diagnosis | 657 | ||
| Treatment and Behavior | 657 | ||
| Personal Comments | 657 | ||
| Juvenile Multifocal Myofibromatosis | 658 | ||
| Congenital Fibromatosis–like Fibrosarcoma (Infantile Fibrosarcoma) | 658 | ||
| Malignant Fibrous Histiocytoma | 663 | ||
| Definition | 663 | ||
| Incidence and Location | 663 | ||
| Radiographic Imaging | 665 | ||
| Gross Findings | 665 | ||
| Microscopic Findings | 665 | ||
| Special Techniques | 665 | ||
| Personal Comments | 682 | ||
| Differential Diagnosis | 682 | ||
| Treatment and Behavior | 682 | ||
| Fibrosarcoma | 682 | ||
| Definition | 682 | ||
| Incidence and Location | 683 | ||
| Clinical Symptoms | 683 | ||
| Radiographic Imaging | 683 | ||
| Gross Findings | 685 | ||
| Microscopic Findings | 685 | ||
| Differential Diagnosis | 685 | ||
| Treatment and Behavior | 685 | ||
| References | 685 | ||
| Nonossifying Fibroma | 685 | ||
| Benign Fibrous Histiocytoma | 686 | ||
| Fibromyxoma | 687 | ||
| Angiomatoid Fibrous Histiocytoma | 687 | ||
| Skeletal Fibromatoses | 687 | ||
| Juvenile Multifocal Myofibromatosis | 688 | ||
| Congenital Fibromatosis–like Fibrosarcoma (Infantile Fibrosarcoma) | 689 | ||
| Malignant Fibrous Histiocytoma | 690 | ||
| Fibrosarcoma | 691 | ||
| 10 Giant Cell Lesions | 692 | ||
| Chapter Outline | 692 | ||
| Conventional Giant Cell Tumor of Bone | 692 | ||
| Definition | 692 | ||
| Incidence and Localization | 692 | ||
| Radiographic Imaging | 693 | ||
| Gross Findings | 699 | ||
| Microscopic Findings | 699 | ||
| Cytology | 711 | ||
| Differential Diagnosis | 711 | ||
| Treatment and Behavior | 717 | ||
| Special Techniques | 720 | ||
| Personal Comments | 722 | ||
| Conventional Giant Cell Tumor in Different Anatomic Sites | 722 | ||
| Giant Cell Tumor of Long Tubular Bones. | 722 | ||
| Giant Cell Tumor of Small Bones of Hands and Feet. | 724 | ||
| Giant Cell Tumor of Vertebral Column. | 724 | ||
| Giant Cell Tumor of Flat Bones. | 727 | ||
| Giant Cell Tumor of Craniofacial Bones. | 727 | ||
| Multifocal Conventional Giant Cell Tumor | 728 | ||
| Conventional Giant Cell Tumor with Pulmonary Metastases | 730 | ||
| Giant Cell Tumor in Paget’s Disease | 730 | ||
| Malignant Giant Cell Tumor | 736 | ||
| Secondary Malignant Giant Cell Tumor | 736 | ||
| Primary Malignant Giant Cell Tumor | 736 | ||
| Giant Cell Reparative Granuloma | 742 | ||
| Definition | 742 | ||
| Incidence and Location | 742 | ||
| Radiographic Imaging | 742 | ||
| Gross Findings | 743 | ||
| Microscopic Findings | 743 | ||
| Special Techniques | 743 | ||
| Differential Diagnosis | 747 | ||
| Treatment and Behavior | 752 | ||
| Personal Comments | 752 | ||
| Cherubism and Related Syndromes | 752 | ||
| References | 755 | ||
| Conventional Giant-Cell Tumor of Bone | 755 | ||
| Giant-Cell Reparative Granuloma | 757 | ||
| 11 Ewing’s Sarcoma and Related Tumors | 760 | ||
| Chapter Outline | 760 | ||
| Chromosomal Translocations | 760 | ||
| Prototypic Chromosomal Translocations Involving EWSR1 and ETS Partners | 762 | ||
| Translocation t(11;22)(q24;q12) with EWSR1-FLI1 Chimeric Gene | 762 | ||
| Translocation t(21;22)(q22;q12) with EWSR1-ERG Chimeric Gene | 764 | ||
| Translocations with Alternative ETS Fusion Partners | 765 | ||
| Translocations with Non-ETS Fusion Partners | 765 | ||
| Unified Pathogenetic Concept of Ewing’s Sarcoma and Related Tumors | 767 | ||
| Ewing’s Sarcoma | 770 | ||
| Definition | 770 | ||
| Incidence and Location | 770 | ||
| Radiographic Imaging | 772 | ||
| Gross Findings | 780 | ||
| Microscopic Findings | 780 | ||
| Cytology | 795 | ||
| Electron Microscopic Findings | 795 | ||
| Treatment and Behavior | 795 | ||
| Primitive Neuroectodermal Tumor | 800 | ||
| Definition | 800 | ||
| Incidence and Location | 800 | ||
| Microscopic Findings | 800 | ||
| Electron Microscopic Findings | 802 | ||
| Treatment and Behavior | 802 | ||
| Askin’s Tumor | 802 | ||
| Immunohistochemical Features of Ewing’s Sarcoma and PNET | 805 | ||
| Differential Diagnosis of Small Round-Cell Tumors of Bone | 809 | ||
| References | 811 | ||
| Chromosomal Translocations | 811 | ||
| Unified Pathogenetic Concept of Ewing’s Sarcoma and Related Tumors | 813 | ||
| Ewing’s Sarcoma | 813 | ||
| Primitive Neuroectodermal Tumor | 814 | ||
| Askin’s Tumor | 815 | ||
| Immunohistochemical Features of Ewing’s Sarcoma and PNET | 815 | ||
| Differential Diagnosis of Small Round-Cell Tumors of Bone | 816 | ||
| 12 Hematopoietic Tumors | 817 | ||
| Chapter Outline | 817 | ||
| Classification of Hematopoietic Tumors | 817 | ||
| Plasma Cell Myeloma and Plasma Cell Neoplasms | 818 | ||
| Definition | 818 | ||
| Clinical Features | 818 | ||
| Radiographic Imaging | 821 | ||
| Gross Findings | 825 | ||
| Microscopic Findings | 825 | ||
| Immunohistochemistry and Differential Diagnosis | 825 | ||
| Genetic Features and Pathogenesis | 835 | ||
| Amyloidosis Associated with Multiple Myeloma | 840 | ||
| Distinct Forms of Myeloma | 840 | ||
| Solitary Plasmacytoma of Bone. | 841 | ||
| Extramedullary Plasmacytoma. | 841 | ||
| Nonsecretory Myeloma. | 841 | ||
| Plasma Cell Leukemia. | 842 | ||
| Osteosclerotic Myeloma (POEMS). | 842 | ||
| Non-Hodgkin’s Lymphoma | 842 | ||
| Definition | 842 | ||
| Diffuse Large B-cell Lymphoma | 843 | ||
| Clinical Features | 843 | ||
| Radiographic Imaging | 845 | ||
| Gross Findings | 845 | ||
| Microscopic Findings | 845 | ||
| Immunohistochemical Stains and Differential Diagnosis | 845 | ||
| Genetic Features and Pathogenesis | 851 | ||
| Adult T-Cell Lymphoma/Leukemia | 853 | ||
| Definition | 853 | ||
| Clinical Features | 853 | ||
| Radiographic Findings | 854 | ||
| Microscopic Findings | 855 | ||
| Immunohistochemical Stains and Differential Diagnosis | 855 | ||
| Genetic Features and Pathogenesis | 855 | ||
| Classical Hodgkin’s Lymphoma | 855 | ||
| Definition | 855 | ||
| Clinical Features | 855 | ||
| Radiographic Imaging | 858 | ||
| Microscopic Findings | 858 | ||
| Immunohistochemical Stains and Differential Diagnosis | 858 | ||
| Genetic Features and Pathogenesis | 862 | ||
| Histiocytic and Dendritic Cell Proliferations | 862 | ||
| Langerhans Cell Histiocytosis | 862 | ||
| Definition | 862 | ||
| Clinical Features | 863 | ||
| Radiographic Imaging | 864 | ||
| Gross Findings | 865 | ||
| Microscopic Findings | 871 | ||
| Immunohistochemical Stains, Special Techniques, and Differential Diagnosis | 871 | ||
| Genetic Features and Pathogenesis | 874 | ||
| Erdheim-Chester Disease | 875 | ||
| Definition | 875 | ||
| Clinical Features | 876 | ||
| Treatment and Behavior | 878 | ||
| Radiographic Imaging | 878 | ||
| Microscopic Findings | 878 | ||
| Immunohistochemical Stains and Differential Diagnosis | 879 | ||
| Genetic Features and Pathogenesis | 880 | ||
| Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) | 883 | ||
| Definition | 883 | ||
| Clinical Features | 883 | ||
| Radiographic Imaging | 883 | ||
| Microscopic Findings | 883 | ||
| Genetic Features and Pathogenesis | 885 | ||
| Myeloid Sarcoma | 885 | ||
| Definition | 885 | ||
| Clinical Features | 885 | ||
| Radiographic Imaging | 885 | ||
| Microscopic Findings | 887 | ||
| Immunohistochemical Stains and Differential Diagnosis | 887 | ||
| Genetic Findings and Pathogenesis | 887 | ||
| Mastocytosis | 890 | ||
| Definition | 890 | ||
| Clinical Features | 890 | ||
| Radiographic Imaging | 892 | ||
| Microscopic Findings | 893 | ||
| Immunohistochemical Stains, Special Studies, and Differential Diagnosis | 893 | ||
| Genetic Features and Pathogenesis | 896 | ||
| References | 896 | ||
| Classification of Hematopoietic Tumors | 896 | ||
| Plasma Cell Myeloma and Plasma Cell Neoplasms | 896 | ||
| Non-Hodgkin’s Lymphoma | 897 | ||
| Classical Hodgkin’s Lymphoma | 899 | ||
| Histiocytic and Dendritic Cell Proliferations | 899 | ||
| Myeloid Sarcoma | 900 | ||
| Mastocytosis | 901 | ||
| 13 Vascular Lesions | 903 | ||
| Chapter Outline | 903 | ||
| Benign Vascular Lesions | 904 | ||
| Hemangioma | 904 | ||
| Definition | 904 | ||
| Incidence and Location | 904 | ||
| Radiographic Imaging | 904 | ||
| Gross Findings | 907 | ||
| Microscopic Findings | 908 | ||
| Epithelioid Hemangioma | 910 | ||
| Differential Diagnosis | 915 | ||
| Treatment and Behavior | 915 | ||
| Hemangiomas in Different Anatomic Sites | 916 | ||
| Hemangiomas of Craniofacial Bones. | 916 | ||
| Hemangiomas of Vertebral Column. | 916 | ||
| Hemangiomas of Other Skeletal Sites. | 916 | ||
| Personal Comments | 916 | ||
| Lymphangioma and Lymphangiomatosis | 919 | ||
| Angiomatoses | 919 | ||
| Cystic Angiomatosis | 919 | ||
| Massive Osteolysis | 922 | ||
| Vascular Malformations | 931 | ||
| Glomus Tumor | 931 | ||
| Definition | 932 | ||
| Incidence and Location | 932 | ||
| Clinical Symptoms | 932 | ||
| Radiographic Imaging | 932 | ||
| Gross Findings | 932 | ||
| Microscopic Findings | 939 | ||
| Treatment and Behavior | 942 | ||
| Malignant Vascular Tumors | 942 | ||
| Epithelioid Hemangioendothelioma | 942 | ||
| Definition | 942 | ||
| Incidence and Location | 942 | ||
| Radiographic Imaging | 942 | ||
| Gross Findings | 942 | ||
| Microscopic Findings | 942 | ||
| Differential Diagnosis | 956 | ||
| Treatment and Behavior | 956 | ||
| Spindle-cell Hemangioendothelioma | 965 | ||
| Angiosarcoma | 965 | ||
| Definition | 965 | ||
| Incidence and Location | 965 | ||
| Radiographic Imaging | 965 | ||
| Microscopic Findings | 965 | ||
| Differential Diagnosis | 975 | ||
| Treatment and Behavior | 975 | ||
| Hemangiopericytoma | 975 | ||
| Definition | 975 | ||
| Incidence and Location | 975 | ||
| Radiographic Imaging | 976 | ||
| Microscopic Findings | 976 | ||
| Differential Diagnosis | 976 | ||
| Treatment and Behavior | 978 | ||
| Kaposi’s Sarcoma | 978 | ||
| Incidence and Location | 978 | ||
| Radiographic Imaging | 978 | ||
| Microscopic Findings | 978 | ||
| Differential Diagnosis | 979 | ||
| Treatment and Behavior | 979 | ||
| Reactive Vascular Lesions | 979 | ||
| Bacillary Angiomatosis of Bone | 979 | ||
| References | 985 | ||
| Benign Vascular Lesions | 985 | ||
| Lymphangioma and Lymphangiomatosis | 986 | ||
| Angiomatoses | 986 | ||
| Glomus Tumor | 986 | ||
| Malignant Vascular Tumors | 987 | ||
| Spindle-Cell Hemangioendothelioma | 987 | ||
| Angiosarcoma | 987 | ||
| Hemangiopericytoma | 988 | ||
| Kaposi’s Sarcoma | 988 | ||
| Reactive Vascular Lesions | 989 | ||
| 14 Neurogenous Tumors and Neurofibromatosis Affecting Bone | 990 | ||
| Chapter Outline | 990 | ||
| Meningioma | 990 | ||
| Radiologic Features | 992 | ||
| Microscopic Findings | 996 | ||
| Clinical Behavior | 999 | ||
| Solitary Fibrous Tumor/Hemangiopericytoma Family Tumors | 1006 | ||
| Radiologic Features | 1006 | ||
| Gross Findings | 1006 | ||
| Microscopic Findings | 1006 | ||
| Myxopapillary Ependymoma | 1008 | ||
| Intraosseous Schwannoma | 1008 | ||
| Definition | 1008 | ||
| Incidence and Location | 1008 | ||
| Clinical Symptoms | 1008 | ||
| Radiographic Imaging | 1012 | ||
| Gross Findings | 1012 | ||
| Microscopic Findings | 1012 | ||
| Special Techniques | 1012 | ||
| Differential Diagnosis | 1012 | ||
| Treatment and Behavior | 1012 | ||
| Neurogenic Tumor Predisposition Syndromes | 1012 | ||
| Neurofibromatosis Type 1 | 1012 | ||
| Clinical Symptoms | 1020 | ||
| Café Au Lait Spots. | 1020 | ||
| Neurofibroma. | 1020 | ||
| Schwannoma. | 1025 | ||
| Malignant Peripheral Nerve Sheath Tumor. | 1025 | ||
| Skeletal Anomalies. | 1033 | ||
| Neurofibromatosis Type 2 | 1038 | ||
| Neurofibromatosis Type 3 (Schwannomatosis) | 1038 | ||
| Von Hippel-Lindau Disease | 1043 | ||
| Hemangioblastoma | 1046 | ||
| 15 Cystic Lesions | 1055 | ||
| Chapter Outline | 1055 | ||
| Aneurysmal Bone Cyst | 1055 | ||
| Primary Aneurysmal Bone Cyst | 1056 | ||
| Definition | 1056 | ||
| Incidence and Location | 1056 | ||
| Clinical Symptoms | 1057 | ||
| Radiographic Imaging | 1057 | ||
| Gross Findings | 1066 | ||
| Microscopic Findings | 1066 | ||
| Differential Diagnosis | 1066 | ||
| Treatment and Behavior | 1073 | ||
| Secondary Aneurysmal Bone Cyst | 1073 | ||
| Definition | 1073 | ||
| Incidence and Location | 1073 | ||
| Radiographic Imaging | 1073 | ||
| Microscopic Findings | 1076 | ||
| Differential Diagnosis | 1076 | ||
| Treatment and Behavior | 1076 | ||
| Personal Comments | 1076 | ||
| Soft Tissue Aneurysmal Bone Cyst | 1076 | ||
| Solitary Bone Cyst | 1076 | ||
| Definition | 1076 | ||
| Incidence and Location | 1076 | ||
| Clinical Symptoms | 1079 | ||
| Radiographic Imaging | 1079 | ||
| Gross Findings | 1085 | ||
| Microscopic Findings | 1085 | ||
| Differential Diagnosis | 1085 | ||
| Treatment and Behavior | 1085 | ||
| Intraosseous Ganglion | 1085 | ||
| Definition | 1085 | ||
| Incidence and Location | 1085 | ||
| Clinical Symptoms | 1085 | ||
| Radiographic Imaging | 1089 | ||
| Gross Findings | 1089 | ||
| Microscopic Findings | 1089 | ||
| Differential Diagnosis | 1089 | ||
| Treatment and Behavior | 1093 | ||
| Epidermal Inclusion Cyst and Dermoid Cyst | 1093 | ||
| References | 1096 | ||
| Aneurysmal Bone Cyst | 1096 | ||
| Solitary Bone Cyst | 1097 | ||
| Intraosseous Ganglion | 1098 | ||
| Epidermal and Dermoid Cysts | 1098 | ||
| 16 Miscellaneous Mesenchymal Tumors | 1100 | ||
| Chapter Outline | 1100 | ||
| Lipoma | 1100 | ||
| Definition | 1100 | ||
| Incidence and Location | 1100 | ||
| Intramedullary Lipoma | 1100 | ||
| Radiographic Imaging | 1100 | ||
| Gross Findings | 1100 | ||
| Microscopic Findings | 1100 | ||
| Intracortical and Subperiosteal Lipoma | 1100 | ||
| Parosteal Lipoma | 1105 | ||
| Liposarcoma | 1105 | ||
| 17 Adamantinoma of Long Bone | 1142 | ||
| Chapter Outline | 1142 | ||
| Classic Adamantinoma | 1142 | ||
| Definition | 1142 | ||
| Incidence and Location | 1143 | ||
| Clinical Symptoms | 1143 | ||
| Radiographic Imaging | 1143 | ||
| Gross Findings | 1144 | ||
| Microscopic Findings | 1144 | ||
| Special Techniques | 1153 | ||
| Differential Diagnosis | 1153 | ||
| Differentiated (Osteofibrous Dysplasia–Like) Adamantinoma | 1157 | ||
| Definition | 1157 | ||
| Incidence and Location | 1157 | ||
| Clinical Symptoms | 1157 | ||
| Radiographic Imaging | 1157 | ||
| Gross Findings | 1157 | ||
| Microscopic Findings | 1157 | ||
| Treatment and Behavior (Classic and Differentiated Adamantinoma) | 1157 | ||
| Personal Comments | 1158 | ||
| Osteofibrous Dysplasia | 1161 | ||
| Definition | 1162 | ||
| Incidence and Location | 1162 | ||
| Radiographic Imaging | 1162 | ||
| Gross Findings | 1163 | ||
| Microscopic Findings | 1163 | ||
| Differential Diagnosis | 1163 | ||
| References | 1171 | ||
| Classic Adamantinoma | 1171 | ||
| Osteofibrous Dysplasia | 1172 | ||
| 18 Chordoma and Related Lesions | 1174 | ||
| Chapter Outline | 1174 | ||
| Notochordal Rests and Benign Notochordal Tumors | 1174 | ||
| Differential Diagnosis | 1179 | ||
| Chordoma | 1179 | ||
| Definition | 1179 | ||
| Incidence and Location | 1179 | ||
| Clinical Symptoms | 1184 | ||
| Radiographic Imaging | 1184 | ||
| Gross Findings | 1187 | ||
| Histology | 1187 | ||
| Cytology | 1187 | ||
| Special Techniques | 1187 | ||
| Differential Diagnosis | 1189 | ||
| Treatment and Behavior | 1206 | ||
| Chondroid Chordoma | 1206 | ||
| Definition | 1206 | ||
| Controversy over Chondroid Chordoma | 1206 | ||
| Personal Comments | 1206 | ||
| Clinical Significance | 1210 | ||
| Dedifferentiated Chordoma | 1210 | ||
| Definition | 1210 | ||
| Incidence and Location | 1210 | ||
| Radiographic Imaging | 1210 | ||
| Gross Findings | 1210 | ||
| Microscopic Findings | 1210 | ||
| Differential Diagnosis | 1214 | ||
| Treatment and Behavior | 1214 | ||
| References | 1214 | ||
| Introduction | 1214 | ||
| Notochordal Rests and Benign Notochordal Tumors | 1214 | ||
| Chordoma | 1214 | ||
| Chondroid Chordoma | 1216 | ||
| Dedifferentiated Chordoma | 1216 | ||
| 19 Metastatic Tumors in Bone | 1217 | ||
| Chapter Outline | 1217 | ||
| Biology of Metastases | 1217 | ||
| General Features of Skeletal Metastases | 1220 | ||
| Skeletal Metastases in Selected Common Neoplasms | 1230 | ||
| Carcinoma of the Lung | 1230 | ||
| Gastrointestinal Carcinoma | 1230 | ||
| Carcinoma of the Breast | 1230 | ||
| Tumors with a Unique Propensity for Skeletal Metastases | 1237 | ||
| Carcinoma of the Prostate | 1237 | ||
| Carcinoma of the Kidney | 1237 | ||
| Carcinoma of the Thyroid | 1239 | ||
| Carcinoma of the Pancreas | 1239 | ||
| Metastatic Melanoma | 1244 | ||
| Skeletal Metastases in Selected Pediatric Tumors | 1244 | ||
| Rhabdomyosarcoma | 1244 | ||
| Neuroblastoma | 1250 | ||
| Clear Cell Sarcoma of the Kidney | 1250 | ||
| References | 1255 | ||
| Biology of Metastases | 1255 | ||
| General Features of Skeletal Metastases | 1255 | ||
| Skeletal Metastases in Selected Common Neoplasms | 1256 | ||
| Tumors with a Unique Propensity for Skeletal Metastases | 1256 | ||
| Metastatic Melanoma | 1257 | ||
| Skeletal Metastases in Selected Pediatric Tumors | 1257 | ||
| 20 Synovial Lesions | 1259 | ||
| Chapter Outline | 1259 | ||
| Synovial Chondromatosis | 1259 | ||
| Definition | 1259 | ||
| Incidence and Location | 1259 | ||
| Clinical Symptoms | 1259 | ||
| Radiographic Imaging | 1259 | ||
| Gross Findings | 1264 | ||
| Microscopic Findings | 1264 | ||
| Differential Diagnosis | 1278 | ||
| Treatment and Behavior | 1278 | ||
| Synovial Chondrosarcoma | 1278 | ||
| Pigmented Villonodular Synovitis | 1286 | ||
| Definition | 1286 | ||
| Incidence and Location | 1286 | ||
| Clinical Symptoms | 1288 | ||
| Radiographic Imaging | 1288 | ||
| Gross Findings | 1288 | ||
| Microscopic Findings | 1291 | ||
| Differential Diagnosis | 1291 | ||
| Treatment and Behavior | 1303 | ||
| Synovial Lipoma | 1303 | ||
| Synovial Hemangioma | 1303 | ||
| References | 1313 | ||
| Synovial Chondromatosis | 1313 | ||
| Synovial Chondrosarcoma | 1313 | ||
| Pigmented Villonodular Synovitis | 1314 | ||
| Synovial Lipoma | 1315 | ||
| Synovial Hemangioma | 1315 | ||
| 21 Sclerosing Bone Lesions | 1317 | ||
| Chapter Outline | 1317 | ||
| Osteoma and Bone Island | 1317 | ||
| Ivory Exostosis | 1317 | ||
| Sinoorbital Osteoma | 1321 | ||
| Bone Island (Enostosis) | 1321 | ||
| Surface Osteoma of Long Bones | 1321 | ||
| Osteopoikilosis (Spotted Bone Disease) | 1321 | ||
| Osteopetrosis | 1333 | ||
| Melorheostosis | 1339 | ||
| References | 1344 | ||
| Osteoma and Bone Islands | 1344 | ||
| Ivory Exostosis | 1344 | ||
| Sino-orbital Osteoma | 1344 | ||
| Bone Island (Enostosis) | 1344 | ||
| Surface Osteoma of Long Bones | 1345 | ||
| Osteopoikolosis (Spotted Bone Disease) | 1345 | ||
| Osteopetrosis | 1345 | ||
| Melorheostosis | 1345 | ||
| 22 Tumor-Induced Osteomalacia and Rickets | 1346 | ||
| Tumor-Induced Osteomalacia | 1346 | ||
| Clinical Data | 1346 | ||
| Radiographic Imaging | 1346 | ||
| Pathologic Findings | 1346 | ||
| Treatment and Behavior | 1347 | ||
| Pathogenesis | 1349 | ||
| References | 1354 | ||
| 23 Reactive and Metabolic Conditions Simulating Neoplasms of Bone | 1357 | ||
| Chapter Outline | 1357 | ||
| Myositis Ossificans | 1357 | ||
| Definition | 1357 | ||
| Incidence and Location | 1357 | ||
| Radiographic Imaging | 1359 | ||
| Gross Findings | 1359 | ||
| Microscopic Findings | 1359 | ||
| Differential Diagnosis | 1363 | ||
| Treatment and Behavior | 1377 | ||
| Myositis Ossificans Progressiva | 1377 | ||
| Definition | 1377 | ||
| Clinical Symptoms | 1377 | ||
| Radiographic Imaging | 1377 | ||
| Microscopic Findings | 1377 | ||
| Differential Diagnosis | 1380 | ||
| Treatment and Behavior | 1380 | ||
| Reactive Lesions of the Bone Surface | 1380 | ||
| Florid Reactive Periostitis | 1380 | ||
| Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) | 1384 | ||
| Acquired Osteochondroma (Turret Exostosis) | 1384 | ||
| Subungual (Dupuytren’s) Exostosis | 1384 | ||
| Exuberant Fracture Callus | 1388 | ||
| Avulsion and Stress Injuries | 1402 | ||
| Avulsion Injuries | 1402 | ||
| Cortical Irregularity Syndrome (Periosteal Desmoid) | 1403 | ||
| Stress Fractures | 1403 | ||
| Pubic Osteolysis | 1403 | ||
| Tumoral Calcinosis | 1409 | ||
| Definition | 1409 | ||
| Incidence and Location | 1409 | ||
| Clinical Symptoms | 1409 | ||
| Radiographic Imaging | 1409 | ||
| Gross Findings | 1409 | ||
| Microscopic Findings | 1409 | ||
| Differential Diagnosis | 1412 | ||
| Treatment and Behavior | 1412 | ||
| Tophaceous Pseudogout | 1412 | ||
| Definition | 1412 | ||
| Clinical Data | 1414 | ||
| Radiographic Imaging | 1414 | ||
| Gross Findings | 1414 | ||
| Microscopic Findings | 1415 | ||
| Differential Diagnosis | 1415 | ||
| Treatment and Behavior | 1415 | ||
| Tophaceous Gout | 1420 | ||
| Clinical Data | 1420 | ||
| Radiographic Imaging | 1420 | ||
| Gross Findings | 1420 | ||
| Microscopic Findings | 1421 | ||
| Chronic Recurrent Multifocal Osteomyelitis | 1421 | ||
| Amyloidosis of Bone | 1422 | ||
| References | 1431 | ||
| Myositis Ossificans | 1431 | ||
| Myositis Ossificans Progressiva | 1431 | ||
| Reactive Lesions of the Bone Surface | 1432 | ||
| Exuberant Fracture Callus | 1433 | ||
| Avulsion and Stress Injuries | 1433 | ||
| Pubic Osteolysis | 1433 | ||
| Tumoral Calcinosis | 1434 | ||
| Tophaceous Pseudogout | 1435 | ||
| Tophaceous Gout | 1435 | ||
| Chronic Recurrent Multifocal Osteomyelitis | 1435 | ||
| Amyloidosis of Bone | 1435 | ||
| 24 Precancerous Conditions | 1437 | ||
| Chapter Outline | 1437 | ||
| Paget’s Disease of Bone | 1437 | ||
| Definition | 1437 | ||
| Incidence and Location | 1438 | ||
| Clinical Symptoms | 1438 | ||
| Radiographic Imaging | 1440 | ||
| Microscopic Findings | 1440 | ||
| Malignant Transformation | 1440 | ||
| Osteomyelitis | 1450 | ||
| Bone Infarcts | 1462 | ||
| Definition | 1462 | ||
| Clinical Findings | 1462 | ||
| Radiographic Imaging | 1462 | ||
| Gross Findings | 1469 | ||
| Microscopic Findings | 1469 | ||
| Treatment and Behavior | 1469 | ||
| Personal Comments | 1469 | ||
| Metallic Implants | 1472 | ||
| Radiation Injury | 1472 | ||
| Osteogenesis Imperfecta | 1472 | ||
| Syndromes Predisposing to Malignancy in Bone | 1474 | ||
| Rothmund-Thomson Syndrome | 1474 | ||
| Li-Fraumeni Syndrome | 1474 | ||
| References | 1480 | ||
| Paget’s Disease of Bone | 1480 | ||
| Osteomyelitis | 1481 | ||
| Bone Infarcts | 1481 | ||
| Metallic Implants | 1481 | ||
| Radiation Injury | 1482 | ||
| Osteogenesis Imperfecta | 1482 | ||
| Syndromes Predisposing to Malignancy in Bone | 1482 | ||
| Index | 1485 | ||
| A | 1485 | ||
| B | 1486 | ||
| C | 1487 | ||
| D | 1490 | ||
| E | 1490 | ||
| F | 1492 | ||
| G | 1493 | ||
| H | 1494 | ||
| I | 1495 | ||
| J | 1496 | ||
| K | 1496 | ||
| L | 1497 | ||
| M | 1497 | ||
| N | 1499 | ||
| O | 1500 | ||
| P | 1501 | ||
| Q | 1503 | ||
| R | 1503 | ||
| S | 1504 | ||
| T | 1505 | ||
| U | 1506 | ||
| V | 1506 | ||
| W | 1506 | ||
| X | 1506 | ||
| Z | 1506 | ||
| Clinical Key ad | IBC1 |