Additional Information
Book Details
Abstract
Ensure you are accurately identifying cells at the microscope with Clinical Hematology Atlas, 5th Edition. An excellent companion to Rodak's Hematology: Clinical Principles & Applications, this award-winning atlas offers complete coverage of the basics of hematologic morphology, including examination of the peripheral blood smear, basic maturation of the blood cell lines, and information on a variety of clinical disorders. Nearly 500 photomicrographs, schematic diagrams, and electron micrographs vividly illustrate hematology from normal cell maturation to the development of various pathologies so you can be sure you’re making accurate conclusions in the lab.
- Schematic diagrams, photomicrographs, and electron micrographs are found in every chapter to visually enhance understanding of hematologic cellular morphology.
- Smaller trim size, concise text, and spiral binding make it easy to reference the atlas in the laboratory.
- Chapter on normal newborn peripheral blood morphology covers the normal cells found in neonatal blood.
- Chapter on body fluids illustrates the other fluids found in the body besides blood, using images from cytocentrifuged specimens.
- The most common cytochemical stains, along with a summary chart for interpretation, are featured in the leukemia chapters to help classify both malignant and benign leukoproliferative disorders.
- Chapter featuring morphologic changes after myeloid hematopoietic growth factors is included in the text.
- Morphologic abnormalities are covered in the chapters on erythrocytes and leukocytes, along with a description of each cell, in a schematic fashion.
- User resources on the Evolve companion site feature review questions and summary tables to further enhance their learning experience.
- NEW! Appendix with comparison tables of commonly confused cells includes lymphocytes versus neutrophilic myelocytes and monocytes versus reactive lymphoctyes to help users see the subtle differences between them.
- NEW! Glossary of hematologic terms at the end of the book provides a quick reference to easily look up definitions.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Inside Front Cover | ES2 | ||
| Clinical Hematology Atlas | iii | ||
| Copyright | iv | ||
| Dedication | v | ||
| Reviewers | vii | ||
| Preface | ix | ||
| Organization | ix | ||
| Evolve | x | ||
| Acknowledgments | xi | ||
| Contents | xiii | ||
| Chapter 1: Introduction to Peripheral Blood Film Examination | 1 | ||
| Wedge film preparation | 2 | ||
| Making the peripheral blood film | 2 | ||
| Staining of peripheral blood films | 5 | ||
| Peripheral film examination | 6 | ||
| 10x Examination | 6 | ||
| 40x OR 50x Examination | 6 | ||
| 100x Examination | 7 | ||
| Summary | 10 | ||
| Chapter 2: Hematopoiesis | 11 | ||
| Chapter 3: Erythrocyte Maturation | 17 | ||
| Pronormoblast | 19 | ||
| Size | 19 | ||
| Nucleus | 19 | ||
| Nucleoli: | 19 | ||
| Chromatin: | 19 | ||
| Cytoplasm | 19 | ||
| N:C Ratio | 19 | ||
| Reference interval: | 19 | ||
| Bone Marrow: | 19 | ||
| Peripheral Blood: | 19 | ||
| Basophilic normoblast | 21 | ||
| Size | 21 | ||
| Nucleus | 21 | ||
| Nucleoli: | 21 | ||
| Chromatin: | 21 | ||
| Cytoplasm | 21 | ||
| N:C Ratio | 21 | ||
| Reference interval: | 21 | ||
| Bone Marrow: | 21 | ||
| Polychromatic normoblast | 23 | ||
| Size | 23 | ||
| Nucleus | 23 | ||
| Nucleoli: | 23 | ||
| Chromatin: | 23 | ||
| Cytoplasm | 23 | ||
| N:C Ratio | 23 | ||
| Reference interval: | 23 | ||
| Bone Marrow: | 23 | ||
| Peripheral Blood: | 23 | ||
| Orthochromic normoblast | 25 | ||
| Size | 25 | ||
| Nucleus | 25 | ||
| Nucleoli: | 25 | ||
| Chromatin: | 25 | ||
| Cytoplasm | 25 | ||
| N:C Ratio | 25 | ||
| Reference interval: | 25 | ||
| Bone Marrow: | 25 | ||
| Peripheral Blood: | 25 | ||
| Polychromatic erythrocyte | 27 | ||
| Size | 27 | ||
| Nucleus | 27 | ||
| Nucleoli: | 27 | ||
| Chromatin: | 27 | ||
| Cytoplasm | 27 | ||
| N:C Ratio | 27 | ||
| Reference interval: | 27 | ||
| Bone Marrow: | 27 | ||
| Peripheral Blood: | 27 | ||
| Erythrocyte | 29 | ||
| Size | 29 | ||
| Nucleus | 29 | ||
| Nucleoli: | 29 | ||
| Chromatin: | 29 | ||
| Cytoplasm | 29 | ||
| N:C Ratio | 29 | ||
| Reference interval: | 29 | ||
| Bone Marrow: | 29 | ||
| Peripheral Blood: | 29 | ||
| Chapter 4: Megakaryocyte Maturation | 31 | ||
| Megakaryoblast (MK-I) | 33 | ||
| Size | 33 | ||
| Nucleus | 33 | ||
| Nucleoli: | 33 | ||
| Chromatin: | 33 | ||
| Cytoplasm | 33 | ||
| Granules: | 33 | ||
| N:C Ratio | 33 | ||
| Reference interval: | 33 | ||
| Bone Marrow: | 33 | ||
| Peripheral Blood: | 33 | ||
| Promegakaryocyte (MK-II) | 35 | ||
| Size | 35 | ||
| Nucleus | 35 | ||
| Nucleoli: | 35 | ||
| Chromatin: | 35 | ||
| Cytoplasm | 35 | ||
| Granules: | 35 | ||
| N:C Ratio | 35 | ||
| Reference interval: | 35 | ||
| Bone Marrow: | 35 | ||
| Peripheral Blood: | 35 | ||
| Megakaryocyte (MK-III) | 37 | ||
| Size | 37 | ||
| Nucleus | 37 | ||
| Cytoplasm | 37 | ||
| Granules: | 37 | ||
| N:C Ratio | 37 | ||
| Reference interval: | 37 | ||
| Bone Marrow: | 37 | ||
| Peripheral Blood: | 37 | ||
| Platelet | 39 | ||
| Size | 39 | ||
| Nucleus | 39 | ||
| Cytoplasm | 39 | ||
| Granules: | 39 | ||
| N:C Ratio | 39 | ||
| Reference interval: | 39 | ||
| Bone Marrow: | 39 | ||
| Peripheral Blood: | 39 | ||
| Chapter 5: Neutrophil Maturation | 41 | ||
| Myeloblast | 43 | ||
| Size | 43 | ||
| Nucleus | 43 | ||
| Nucleoli: | 43 | ||
| Chromatin: | 43 | ||
| Cytoplasm | 43 | ||
| Granules: | 43 | ||
| N:C Ratio | 43 | ||
| Reference interval: | 43 | ||
| Bone Marrow: | 43 | ||
| Peripheral Blood: | 43 | ||
| Promyelocyte (Progranulocyte) | 45 | ||
| Size | 45 | ||
| Nucleus | 45 | ||
| Nucleoli: | 45 | ||
| Chromatin: | 45 | ||
| Cytoplasm | 45 | ||
| Granules: | 45 | ||
| Primary: | 45 | ||
| Secondary: | 45 | ||
| N:C Ratio | 45 | ||
| Reference interval: | 45 | ||
| Bone Marrow: | 45 | ||
| Peripheral Blood: | 45 | ||
| Neutrophilic myelocyte | 47 | ||
| Size | 47 | ||
| Nucleus | 47 | ||
| Nucleoli: | 47 | ||
| Chromatin: | 47 | ||
| Cytoplasm | 47 | ||
| Granules: | 47 | ||
| Primary: | 47 | ||
| Secondary: | 47 | ||
| N:C Ratio | 47 | ||
| Reference interval: | 47 | ||
| Bone Marrow: | 47 | ||
| Peripheral Blood: | 47 | ||
| Neutrophilic metamyelocyte | 49 | ||
| Size | 49 | ||
| Nucleus | 49 | ||
| Nucleoli: | 49 | ||
| Chromatin: | 49 | ||
| Cytoplasm | 49 | ||
| Granules: | 49 | ||
| Primary: | 49 | ||
| Secondary: | 49 | ||
| N:C Ratio | 49 | ||
| Reference interval: | 49 | ||
| Bone Marrow: | 49 | ||
| Peripheral Blood: | 49 | ||
| Neutrophilic band | 51 | ||
| Size | 51 | ||
| Nucleus | 51 | ||
| Nucleoli: | 51 | ||
| Chromatin: | 51 | ||
| Cytoplasm | 51 | ||
| Granules: | 51 | ||
| Primary: | 51 | ||
| Secondary: | 51 | ||
| N:C Ratio | 51 | ||
| Reference interval: | 51 | ||
| Bone Marrow: | 51 | ||
| Peripheral Blood: | 51 | ||
| Segmented neutrophil | 53 | ||
| Size | 53 | ||
| Nucleus | 53 | ||
| Nucleoli: | 53 | ||
| Chromatin: | 53 | ||
| Cytoplasm | 53 | ||
| Granules: | 53 | ||
| Primary: | 53 | ||
| Secondary: | 53 | ||
| N:C Ratio | 53 | ||
| Reference interval: | 53 | ||
| Bone Marrow: | 53 | ||
| Peripheral Blood: | 53 | ||
| Chapter 6: Monocyte Maturation | 55 | ||
| Monoblast | 57 | ||
| Size | 57 | ||
| Nucleus | 57 | ||
| Nucleoli: | 57 | ||
| Chromatin: | 57 | ||
| Cytoplasm | 57 | ||
| Granules: | 57 | ||
| N:C Ratio | 57 | ||
| Reference interval: | 57 | ||
| Bone Marrow: | 57 | ||
| Peripheral Blood: | 57 | ||
| Promonocyte | 59 | ||
| Size | 59 | ||
| Nucleus | 59 | ||
| Nucleoli: | 59 | ||
| Chromatin: | 59 | ||
| Cytoplasm | 59 | ||
| Granules: | 59 | ||
| N:C Ratio | 59 | ||
| Reference interval: | 59 | ||
| Bone Marrow: | 59 | ||
| Peripheral Blood: | 59 | ||
| Monocyte | 61 | ||
| Size | 61 | ||
| Nucleus | 61 | ||
| Nucleoli: | 61 | ||
| Chromatin: | 61 | ||
| Cytoplasm | 61 | ||
| Granules: | 61 | ||
| Vacuoles: | 61 | ||
| N:C Ratio | 61 | ||
| Reference interval: | 61 | ||
| Bone Marrow: | 61 | ||
| Peripheral Blood: | 61 | ||
| Macrophage (histiocyte) | 63 | ||
| Size | 63 | ||
| Nucleus | 63 | ||
| Nucleoli: | 63 | ||
| Chromatin: | 63 | ||
| Cytoplasm | 63 | ||
| Granules: | 63 | ||
| Vacuoles: | 63 | ||
| Reference interval | 63 | ||
| Chapter 7: Eosinophil Maturation | 65 | ||
| Eosinophilic myelocyte | 67 | ||
| Size | 67 | ||
| Nucleus | 67 | ||
| Nucleoli: | 67 | ||
| Chromatin: | 67 | ||
| Cytoplasm | 67 | ||
| Granules: | 67 | ||
| Primary: | 67 | ||
| Secondary: | 67 | ||
| N:C Ratio | 67 | ||
| Reference interval: | 67 | ||
| Bone Marrow: | 67 | ||
| Peripheral Blood: | 67 | ||
| Eosinophilic metamyelocyte | 69 | ||
| Size | 69 | ||
| Nucleus | 69 | ||
| Nucleoli: | 69 | ||
| Chromatin: | 69 | ||
| Cytoplasm | 69 | ||
| Granules: | 69 | ||
| Primary: | 69 | ||
| Secondary: | 69 | ||
| N:C Ratio | 69 | ||
| Reference interval: | 69 | ||
| Bone Marrow: | 69 | ||
| Peripheral Blood: | 69 | ||
| Eosinophilic band | 71 | ||
| Size | 71 | ||
| Nucleus | 71 | ||
| Nucleoli: | 71 | ||
| Chromatin: | 71 | ||
| Cytoplasm | 71 | ||
| Granules: | 71 | ||
| Primary: | 71 | ||
| Secondary: | 71 | ||
| N:C Ratio | 71 | ||
| Reference interval: | 71 | ||
| Bone Marrow: | 71 | ||
| Peripheral Blood: | 71 | ||
| Eosinophil | 73 | ||
| Size | 73 | ||
| Nucleus | 73 | ||
| Nucleoli: | 73 | ||
| Chromatin: | 73 | ||
| Cytoplasm | 73 | ||
| Granules: | 73 | ||
| Primary: | 73 | ||
| Secondary: | 73 | ||
| N:C Ratio | 73 | ||
| Reference interval: | 73 | ||
| Bone Marrow: | 73 | ||
| Peripheral Blood: | 73 | ||
| Chapter 8: Basophil Maturation | 75 | ||
| Basophil | 77 | ||
| Size | 77 | ||
| Nucleus | 77 | ||
| Nucleoli: | 77 | ||
| Chromatin: | 77 | ||
| Cytoplasm | 77 | ||
| Granules: | 77 | ||
| Primary: | 77 | ||
| Secondary: | 77 | ||
| N:C Ratio | 77 | ||
| Reference interval: | 77 | ||
| Bone Marrow: | 77 | ||
| Peripheral Blood: | 77 | ||
| Chapter 9: Lymphocyte Maturation | 79 | ||
| Lymphoblast | 81 | ||
| Size | 81 | ||
| Nucleus | 81 | ||
| Nucleoli: | 81 | ||
| Chromatin: | 81 | ||
| Cytoplasm | 81 | ||
| Granules: | 81 | ||
| N:C Ratio | 81 | ||
| Reference interval: | 81 | ||
| Bone Marrow: | 81 | ||
| Peripheral Blood: | 81 | ||
| Prolymphocyte | 83 | ||
| Size | 83 | ||
| Nucleus | 83 | ||
| Nucleoli: | 83 | ||
| Chromatin: | 83 | ||
| Cytoplasm | 83 | ||
| Granules: | 83 | ||
| N:C Ratio | 83 | ||
| Reference interval: | 83 | ||
| Bone Marrow: | 83 | ||
| Peripheral Blood: | 83 | ||
| Lymphocyte | 85 | ||
| Size | 85 | ||
| Nucleus | 85 | ||
| Nucleoli: | 85 | ||
| Chromatin: | 85 | ||
| Cytoplasm | 85 | ||
| Granules: | 85 | ||
| N:C Ratio | 85 | ||
| Reference Interval (for combined small and large lymphocytes): | 85 | ||
| Bone Marrow: | 85 | ||
| Peripheral Blood: | 85 | ||
| Plasma cell | 87 | ||
| Size | 87 | ||
| Nucleus | 87 | ||
| Nucleoli: | 87 | ||
| Chromatin: | 87 | ||
| Cytoplasm | 87 | ||
| Granules: | 87 | ||
| Vacuoles: | 87 | ||
| N:C Ratio | 87 | ||
| Reference interval: | 87 | ||
| Bone Marrow: | 87 | ||
| Peripheral Blood: | 87 | ||
| Chapter 10: Variations in Size and Color of Erythrocytes | 89 | ||
| Variations in size | 90 | ||
| Chapter 11: Variations in Shape and Distribution of Erythrocytes | 93 | ||
| Poikilocytosis | 94 | ||
| Acanthocyte | 94 | ||
| Description | 94 | ||
| Associated with | 94 | ||
| Schistocyte | 95 | ||
| Description | 95 | ||
| Associated with | 95 | ||
| Echinocyte | 96 | ||
| Description | 96 | ||
| Associated with | 96 | ||
| Spherocyte | 97 | ||
| Description | 97 | ||
| Associated with | 97 | ||
| Target Cell | 98 | ||
| Description | 98 | ||
| Associated with | 98 | ||
| Sickle Cell | 99 | ||
| Description | 99 | ||
| Associated with | 99 | ||
| Hemoglobin C Crystal | 100 | ||
| Description | 100 | ||
| Associated with | 100 | ||
| Hemoglobin SC Crystal | 101 | ||
| Description | 101 | ||
| Associated with | 101 | ||
| Elliptocyte/Ovalocyte | 102 | ||
| Chapter 12: Inclusions in Erythrocytes | 107 | ||
| Howell-Jolly Bodies | 108 | ||
| Color | 108 | ||
| Shape | 108 | ||
| Size | 108 | ||
| Number per cell | 108 | ||
| Composition | 108 | ||
| Associated with | 108 | ||
| Basophilic Stippling | 109 | ||
| Color | 109 | ||
| Shape | 109 | ||
| Number per cell | 109 | ||
| Composition | 109 | ||
| Associated with | 109 | ||
| Pappenheimer Bodies | 110 | ||
| Color | 110 | ||
| Shape | 110 | ||
| Number per cell | 110 | ||
| Composition | 110 | ||
| Associated with | 110 | ||
| Cabot Rings | 111 | ||
| Color | 111 | ||
| Shape | 111 | ||
| Number per cell | 111 | ||
| Composition | 111 | ||
| Associated with | 111 | ||
| Inclusions with supravital stain | 112 | ||
| Chapter 13: Diseases Affecting Erythrocytes | 115 | ||
| Microcytic hypochromic | 116 | ||
| Iron deficiency anemia | 116 | ||
| Peripheral Blood | 116 | ||
| β-Thalassemia minor | 117 | ||
| Chapter 14: Nuclear and Cytoplasmic Changes in Leukocytes | 131 | ||
| Hyposegmentation of neutrophils | 132 | ||
| Description | 132 | ||
| Associated with | 132 | ||
| Hypersegmentation of neutrophils | 133 | ||
| Description | 133 | ||
| Associated with | 133 | ||
| Vacuolation in Neutrophils | 134 | ||
| Description | 134 | ||
| Number | 134 | ||
| Associated with | 134 | ||
| Döhle body | 135 | ||
| Description | 135 | ||
| Composition | 135 | ||
| Number | 135 | ||
| Associated with | 135 | ||
| Toxic granulation | 136 | ||
| Description | 136 | ||
| Composition | 136 | ||
| Number | 136 | ||
| Associated with | 136 | ||
| Hypogranulation/agranulation in Neutrophils | 137 | ||
| Description | 137 | ||
| Associated with | 137 | ||
| Reactive lymphocytes | 138 | ||
| Description | 138 | ||
| Nucleus | 138 | ||
| Nucleoli: | 138 | ||
| Chromatin: | 138 | ||
| Cytoplasm | 138 | ||
| Granules: | 138 | ||
| Vacuoles: | 138 | ||
| Associated with | 138 | ||
| Chapter 15: Acute Myeloid Leukemia | 139 | ||
| Acute myeloid leukemia, minimally differentiated | 141 | ||
| Morphology: | 141 | ||
| Peripheral Blood | 141 | ||
| Bone Marrow | 141 | ||
| Cytochemistry: | 141 | ||
| Myeloperoxidase | 141 | ||
| Sudan Black B | 141 | ||
| Nonspecific Esterase | 141 | ||
| Genetics: | 141 | ||
| Immunophenotype: | 141 | ||
| Acute myeloid leukemia without maturation | 142 | ||
| Chapter 16: Precursor Lymphoid Neoplasms | 157 | ||
| Acute lymphoblastic leukemia, small blasts | 159 | ||
| Morphology: | 159 | ||
| Peripheral Blood: | 159 | ||
| Bone Marrow: | 159 | ||
| Acute lymphoblastic leukemia, large blasts | 160 | ||
| Morphology: | 160 | ||
| Peripheral Blood: | 160 | ||
| Bone Marrow: | 160 | ||
| Chapter 17: Myeloproliferative Neoplasms | 161 | ||
| Chronic Myelogenous Leukemia, BCR-ABL1 Positive | 163 | ||
| Morphology | 164 | ||
| Peripheral Blood: | 164 | ||
| Leukocytes | 164 | ||
| Erythrocytes | 164 | ||
| Platelets | 164 | ||
| Bone Marrow: Chronic phase* | 164 | ||
| Leukocyte Alkaline Phosphatase (LAP) | 165 | ||
| Genetics | 166 | ||
| Polycythemia Vera | 167 | ||
| Morphology | 167 | ||
| Peripheral Blood: | 167 | ||
| Leukocytes | 167 | ||
| Erythrocytes | 167 | ||
| Platelets | 167 | ||
| Bone Marrow: | 167 | ||
| Genetics | 167 | ||
| Essential Thrombocythemia | 168 | ||
| Morphology | 168 | ||
| Peripheral Blood: | 168 | ||
| Leukocytes | 168 | ||
| Erythrocytes | 168 | ||
| Platelets | 168 | ||
| Bone Marrow: | 168 | ||
| Genetics | 168 | ||
| Primary Myelofibrosis | 169 | ||
| Morphology | 169 | ||
| Peripheral Blood: | 169 | ||
| Leukocytes | 169 | ||
| Erythrocytes | 169 | ||
| Platelets | 169 | ||
| Bone Marrow: | 169 | ||
| Genetics | 169 | ||
| Chapter 18: Myelodysplastic Syndromes | 171 | ||
| Dyserythropoiesis | 173 | ||
| Morphology | 173 | ||
| Peripheral Blood: | 173 | ||
| Bone Marrow: | 173 | ||
| Dysmyelopoiesis | 176 | ||
| Chapter 19: Mature Lymphoproliferative Disorders | 181 | ||
| Chronic Lymphocytic Leukemia | 182 | ||
| Morphology | 183 | ||
| Peripheral Blood: | 183 | ||
| Bone Marrow: | 183 | ||
| Immunophenotype | 183 | ||
| Prolymphocytic Leukemia | 184 | ||
| Morphology | 184 | ||
| Peripheral Blood: | 184 | ||
| Bone Marrow: | 184 | ||
| Immunophenotype | 184 | ||
| Hairy Cell Leukemia | 185 | ||
| Morphology | 185 | ||
| Peripheral Blood: | 185 | ||
| Bone Marrow: | 185 | ||
| Immunophenotype | 185 | ||
| Plasma Cell Myeloma | 186 | ||
| Morphology | 187 | ||
| Peripheral Blood: | 187 | ||
| Bone Marrow: | 187 | ||
| Immunophenotype | 187 | ||
| Burkitt Leukemia/Lymphoma | 188 | ||
| Morphology | 188 | ||
| Peripheral Blood: | 188 | ||
| Bone Marrow: | 188 | ||
| Immunophenotype | 188 | ||
| Lymphoma | 189 | ||
| Morphology | 189 | ||
| Peripheral Blood: | 189 | ||
| Bone Marrow: | 189 | ||
| Chapter 20: Morphologic Changes after Myeloid Hematopoietic Growth Factors | 191 | ||
| Chapter 21: Microorganisms | 195 | ||
| Plasmodium Species | 196 | ||
| Babesia Species | 197 | ||
| Description | 197 | ||
| Loa loa | 198 | ||
| Description | 198 | ||
| Trypanosomes | 199 | ||
| Description | 199 | ||
| Fungi | 200 | ||
| Bacteria | 201 | ||
| Chapter 22: Miscellaneous Cells | 203 | ||
| Hematologic Manifestations of Systemic Disorders | 204 | ||
| Chapter 23: Normal Newborn Peripheral Blood Morphology | 215 | ||
| Chapter 24: Body Fluids | 219 | ||
| Cells Commonly Seen In Cerebrospinal Fluid | 222 | ||
| Comments | 222 | ||
| Cells Sometimes Found In Cerebrospinal Fluid | 223 | ||
| Associated with | 224 | ||
| Cells Sometimes Found In Cerebrospinal Fluid After Central Nervous System Hemorrhage | 225 | ||
| Organisms Sometimes Found In Cerebrospinal Fluid | 227 | ||
| Cells Sometimes Found In Serous Body Fluids (Pleural, Pericardial, And Peritoneal) | 228 | ||
| Glossary | 241 | ||
| Appendix: Comparison Tables | 261 | ||
| Index | 265 | ||
| Inside Back Cover | ES3 |