Menu Expand
Applied Pharmacology for the Dental Hygienist - E-Book

Applied Pharmacology for the Dental Hygienist - E-Book

Elena Bablenis Haveles

(2015)

Additional Information

Book Details

Abstract

Covering the most commonly used drugs in dentistry, Applied Pharmacology for the Dental Hygienist, 7th Edition provides an in-depth understanding of the pharmacologic principles needed for safe and effective dental treatment and oral health care. It discusses drug properties and mechanisms of action, dosages, intended effects, interactions, and adverse reactions — both for the medications a patient may already be taking and for the drugs prescribed by the dentist. New to this edition are topics such as drug-related osteonecrosis of the jaw, recommendations for antibiotic prophylaxis to reduce the risk of infection, cholesterol and cardiovascular guidelines, and new information on type 2 diabetes. Written by dental hygiene educator Elena Haveles, this trusted text prepares you for the expanding role of the dental hygienist!

  • Comprehensive coverage provides an in-depth understanding of the most commonly used drugs, how they work, and how they affect patients’ oral health and dental treatment options. 
  • A dental focus addresses the drug interactions of clinical interest in dentistry, with explanations as to why certain drugs are used or contraindicated in a dental treatment plan.
  • A logical format organizes chapters into four parts: 1) general pharmacologic principles, 2) drugs used in dentistry, 3) drugs that may alter dental treatment, and 4) special situations.
  • Clinical Skills Assessment offers review questions at the end of each chapter, helping you assess your knowledge of the material.
  • Dental Hygiene Considerations boxes show how principles of pharmacology apply specifically to dental hygienists.
  • Note boxes highlight important concepts, indications, contraindications, memory tools, warnings, and more.
  • Key terms are bolded and in color within each chapter and defined in a handy glossary. 
  • Summary tables and boxes serve as useful review and study tools with quick, easy-to-read summaries of key concepts.
  • Learning objectives at the beginning of each chapter set goals for what you will accomplish and provide a useful study guide for examinations.
  • A bibliography in each chapter lists resource citations for additional research and study of dental-related topics.
  • Quick-reference appendixes include resources such as the top 200 drugs, medical acronyms, and information on herbal and dietary supplements.
  • A drug index provides easy look-up of specific drugs and types of drugs.
  • NEW! Updated coverage reflects the latest changes and advances relating to dental treatment, such as adverse drug reactions, antibiotic prophylaxis, osteonecrosis of the jaw, cardiovascular and cholesterol guidelines, oral anticoagulant drugs, and type 2 diabetes. 
  • NEW! Full-color design includes additional illustrations showing basic principles and internal processes, along with photographs of oral conditions and side effects.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Inside Front Cover ES2
Applied Pharmacology for the Dental Hygienist i
Copyright ii
Reviewers iii
Dedication iv
Preface v
Intended audience v
Importance to the profession v
Organization v
Key features v
Ancillaries vi
For the Instructor vi
For the Student vi
Acknowledgments vii
How to Be Successful in Pharmacology viii
Use of objectives to focus studying viii
Contents ix
Part One: General Principles 1
Chapter 1: Information, Sources, Regulatory Agencies, Drug Legislation, and Prescription Writing 2
History 2
Role of the dental hygienist 3
Medication/Health History 3
Medication Administration 3
Emergency Situations 3
Appointment Scheduling 3
Nonprescription Medication 3
Nutritional or Herbal Supplements 3
Sources of information 4
Printed Resources 4
Computer and Online Resources 4
Drug names 4
Drug Substitution 5
Federal regulations and regulatory agencies 5
Harrison Narcotic Act 5
Food and Drug Administration 5
Federal Trade Commission 5
Drug Enforcement Administration 5
Omnibus Budget Reconciliation Act 5
Clinical evaluation of a new drug 5
Drug legislation 6
History 6
Scheduled Drugs 6
Package Inserts 7
Black Box Warning 7
Labeled and Off-Label Uses 7
Orphan Drugs 7
Drug Recall 7
Prescription writing 7
Measurement 8
Metric System 8
Household Measures 8
Prescriptions 8
Format 8
Prescription Label Regulations 9
Electronic and Fax Prescribing 9
Role of the Dental Hygienist and Patient Adherence to Medication Therapy 10
Dental hygiene considerations 10
Academic skills assessment 10
Clinical applications 10
Chapter 2: Drug Action and Handling 11
Characterization of drug action 11
Log Dose Effect Curve 11
Potency 11
Efficacy 12
Therapeutic Index 13
Mechanism of action of drugs 13
Receptors 13
Agonists and Antagonists 13
Pharmacokinetics 14
Passage Across Body Membranes 14
Passive Transfer 14
Specialized Transport 14
Absorption 14
Effect of Ionization 15
Oral Absorption 15
Absorption from Injection Site 15
Distribution 15
Basic Principles 15
Distribution By Plasma 16
Blood-Brain Barrier 16
Placenta 16
Enterohepatic Circulation 16
Redistribution 16
Metabolism (Biotransformation) 16
First-Pass Effect 17
Cytochrome P-450 Induction and Inhibition 17
Excretion 18
Clinical Pharmacokinetics 18
Half-Life 18
Kinetics 19
Factors that alter drug effects 19
Routes of administration and dose forms 20
Routes of Administration 20
Oral Route 20
Rectal Route 20
Intravenous Route 20
Intramuscular Route 20
Subcutaneous Route 21
Intradermal Route 21
Intrathecal Route 21
Intraperitoneal Route 21
Inhalation Route 21
Topical Route 23
Dose Forms 24
Dental hygiene considerations 24
Academic skills assessment 24
Clinical case study 24
Chapter 3: Adverse Reactions 25
Definitions and Classifications 25
Clinical Manifestations of Adverse Reactions 26
Exaggerated Effect on Target Tissues 26
Effect on Nontarget Tissues 26
Effect on Fetal Development (Teratogenic Effect) 26
Local Effect 27
Drug Interactions 27
Hypersensitivity (Allergic Reaction) 27
Idiosyncrasy 29
Interference with Natural Defense Mechanisms 29
Toxicologic Evaluation of Drugs 29
Recognizing Adverse Drug Effects 29
Dental Hygiene Considerations 30
Academic Skills Assessment 30
Clinical Case Study 30
Part Two: Drugs Used in Dentistry 31
Chapter 4: Autonomic Drugs 32
Autonomic nervous system 32
Anatomy 32
Parasympathetic Autonomic Nervous System 33
Sympathetic Autonomic Nervous System 33
Functional Organization 33
Neurotransmitters 34
Parasympathetic autonomic nervous system 35
Cholinergic (Parasympathomimetic) Agents 36
Pharmacologic Effects 36
Adverse Reactions 37
Contraindications 37
Uses 37
Anticholinergic (Parasympatholytic) Agents 38
Pharmacologic Effects 38
Adverse Reactions 39
Contraindications 39
Uses 39
Drug Interactions 39
Nicotinic Agonists and Antagonists 40
Sympathetic autonomic nervous system 40
Sympathetic Autonomic Nervous System Receptors 40
α -Receptors 40
β -Receptors 40
Adrenergic (Sympathomimetic) Agents 41
Pharmacologic Effects 41
Adverse Reactions 42
Contraindications 42
Uses 42
Specific Adrenergic Agents 42
Adrenergic Blocking Agents 43
α -Adrenergic Blocking Agents 43
β -Adrenergic Blocking Agents 44
α - and β -Blocking Agents 44
Neuromuscular Blocking Drugs 44
Nondepolarizing (Competitive) Blockers 44
Depolarizing Agents 44
Dental hygiene considerations 44
Cholinergic Drugs 44
Anticholinergic Drugs 44
Xerostomia 44
Tachycardia 44
Sedation 44
Adrenergic Agonists 45
Tachycardia 45
Central Nervous System Excitation and Tremors 45
Drug Interactions 45
Oral β -Adrenergic Agonists 45
Academic skills assessment 45
Clinical case study 45
Chapter 5: Nonopioid (Nonnarcotic) Analgesics 46
Pain 46
Classification 46
Salicylates 47
Acetylsalicylic Acid 47
Chemistry 47
Mechanism of Action 48
Pharmacokinetics 48
Pharmacologic Effects 49
Adverse Reactions 49
Toxicity 50
Drug Interactions 51
Uses 51
Doses and Preparations 51
Nonacetylated Salicylates 52
Common Agents 52
Diflunisal 52
Nonsteroidal antiinflammatory drugs 52
Chemical Classification 52
Mechanism of Action 52
Pharmacokinetics 52
Pharmacologic Effects 52
Adverse Reactions 53
Gastrointestinal Effects 53
Central Nervous System Effects 53
Blood Clotting 53
Cardiovascular Effects 53
Renal Effects 53
Oral Effects 54
Other Effects 54
Hypersensitivity Reactions 54
Pregnancy and Nursing Considerations 54
Drug Interactions 54
Contraindications and Cautions 54
Therapeutic Uses 54
Medical 54
Dental 54
Specific Nonsteroidal Antiinflammatory Drugs 55
Ibuprofen 55
Naproxen Sodium 55
Other Nonsteroidal Antiinflammatory Drugs 56
Cyclo-Oxygenase II–Specific Agents 56
Acetaminophen 56
Pharmacokinetics 56
Pharmacologic Effects 56
Adverse Reactions 56
Hepatic Effects 57
Nephrotoxicity 57
Skin Reactions 57
Drug Interactions 57
Uses 57
Doses and Preparations 58
Drugs used to treat gout 58
Colchicine 58
Allopurinol 58
Probenecid 58
Dental hygiene considerations 58
Academic skills assessment 59
Clinical case study 59
Chapter 6: Opioid (Narcotic) Analgesics and Antagonists 60
History 60
Classification 60
Mechanism of action 60
Pharmacokinetics 61
Pharmacologic effects 62
Analgesia 62
Sedation and Euphoria 62
Cough Suppression 62
Gastrointestinal Effects 62
Adverse reactions 63
Respiratory Depression 63
Nausea and Emesis 63
Constipation 63
Miosis 63
Urinary Retention 63
Central Nervous System Effects 63
Cardiovascular Effects 63
Biliary Tract Constriction 63
Histamine Release 63
Pregnancy and Nursing Considerations 63
Addiction 63
Overdose 64
Withdrawal 64
Identification of an Addict 64
Treatment 64
Allergic Reactions 64
Drug Interactions 64
Specific opioids 64
Opioid Agonists 64
Morphine 64
Oxycodone 65
Oxymorphone 65
Hydrocodone 65
Extended-Release Hydrocodone 67
Codeine 67
Meperidine 67
Hydromorphone 67
Methadone 67
Fentanyl Family 67
Mixed Opioids 67
Agonist-Antagonist Opioids 67
Partial Agonists 67
Opioid Antagonists 67
Naloxone 67
Nalmefene 68
Naltrexone 68
Full Agonist/Reuptake Inhibitors 68
Tapentadol 68
Tramadol 68
Dental use of opioids 68
Chronic dental pain and opioid use 69
Patient Concerns Regarding Opioid Use 69
Dental hygiene considerations 69
Academic skills assessment 69
Clinical case studies 69
Chapter 7: Antiinfective Agents 70
Dental infection “evolution” 71
Definitions 71
Infection 71
Resistance 72
Indications for antimicrobial agents 72
Therapeutic Indications 72
Patient 72
Infection 72
Prophylactic Indications 73
General adverse reactions and disadvantages associated with antiinfective agents 74
Superinfection (Suprainfection) 74
Allergic Reactions 74
Drug Interactions 74
Oral Contraceptives 74
Oral Anticoagulants 74
Gastrointestinal Complaints 74
Pregnancy Considerations 74
Dose Forms 74
Cost 74
Penicillins 75
Pharmacokinetics 75
Mechanism of Action 75
Spectrum 76
Resistance 76
Adverse Reactions 76
Toxicity 76
Allergy and Hypersensitivity 76
Uses 76
Specific Penicillins 77
Penicillin G 77
Penicillin V 77
Penicillinase-Resistant Penicillins 77
Ampicillins 77
Extended-Spectrum Penicillins 77
Cephalosporins 77
Pharmacokinetics 77
Spectrum 78
Mechanism of Action 78
Adverse Reactions 78
Gastrointestinal Effects 78
Nephrotoxicity 78
Superinfection 78
Local Reaction 78
Hemostasis and Disulfiram-Like Reaction 78
Allergy 78
Uses 78
Macrolides 78
Erythromycin 78
Mechanism and Spectrum 78
Pharmacokinetics 79
Adverse Reactions 79
Drug Interactions 79
Uses 79
Azithromycin and Clarithromycin 79
Tetracyclines 79
Pharmacokinetics 80
Spectrum 80
Adverse Reactions 80
Gastrointestinal Effects 80
Effects on Teeth and Bones 80
Hepatotoxicity 81
Nephrotoxicity 81
Hematologic Effects 81
Superinfection 81
Photosensitivity 81
Other Effects 81
Allergy 81
Drug Interactions 81
Cations 81
Enhanced Effect of Other Drugs 81
Reduced Doxycycline Effect 81
General Antibiotic Interactions 81
Uses 81
Medical 81
Dental 81
Clindamycin 82
Pharmacokinetics 82
Spectrum 82
Adverse Reactions 82
Gastrointestinal Effects 82
Superinfection 82
Other Effects 82
Allergy 82
Uses 82
Metronidazole 82
Pharmacokinetics 83
Spectrum 83
Adverse Reactions 83
Gastrointestinal Effects 83
Central Nervous System Effects 83
Renal Toxicity 83
Oral Effects 83
Other Effects 83
Drug Interactions 83
Uses 83
Medical 83
Dental 83
Rational use of antiinfective agents in dentistry 83
Stages of Infection 83
Stage 1 84
Stage 2 84
Stage 3 84
Failure of Antiinfective Therapy 84
Antimicrobial agents for nondental use 84
Vancomycin 84
Spectrum 84
Adverse Reactions 84
Aminoglycosides 84
Pharmacokinetics 85
Part Three: Drugs that May Alter Dental Treatment 157
Chapter 14: Drugs for the Treatment of Cardiovascular Diseases 158
Dental implications of cardiovascular disease 159
Contraindications to Treatment 159
Vasoconstrictor Limit 159
Periodontal Disease and Cardiovascular Disease 159
Heart failure 159
Treatment of Heart Failure 160
Diuretics 160
Angiotensin-Converting Enzyme Inhibitors 161
Angiotensin Receptor Blockers 161
β -Adrenergic Blockers 161
Aldosterone Antagonists 161
Vasodilators 161
Cardiacglycosides 161
Digitalis Glycosides 161
Pharmacologic Effects 161
Uses 161
Adverse Reactions 161
Dental Drug Interactions 162
Management of the Dental Patient Taking Digoxin 162
Part Four: Special situations 262
Chapter 24: Emergency Drugs 263
General measures 263
Steps Indicated 263
Preparation for Treatment 264
Categories of emergencies 264
Lost or Altered Consciousness 264
Syncope 264
Hypoglycemia 264
Diabetic Coma 265
Seizures 265
Respiratory Emergencies 265
Hyperventilation 265
Asthma 265
Anaphylactic Shock 265
Acute Airway Obstruction 265
Cardiovascular System Emergencies 266
Angina Pectoris 266
Acute Myocardial Infarction 266
Cardiac Arrest 266
Other Cardiovascular Emergencies 266
Other Emergency Situations 268
Extrapyramidal Reactions 268
Acute Adrenocortical Insufficiency 268
Thyroid Storm 268
Malignant Hyperthermia 268
Drug-Related Emergencies 268
Opioid Overdose 268
Reaction to Local Anesthetic Agents 268
Epinephrine 268
Emergency kit for the dental office 268
Drugs 268
Level 1 (Critical) Drugs 269
Level 2 Drugs 269
Other Drugs 271
Equipment 271
Dental hygiene considerations 272
Academic skills assessment 272
Clinical case study 272
Chapter 25: Pregnancy and Breastfeeding 273
General principles 273
Two Main Concerns 273
History 273
Pregnancy 274
Pregnancy Trimesters 274
Teratogenicity 274
U.S. Food and Drug Administration Pregnancy Categories 274
Breastfeeding 274
Dental drugs 274
Local Anesthetic Agents 274
Epinephrine 275
Analgesics 275
Aspirin 276
Nonsteroidal Antiinflammatory Drugs 276
Acetaminophen 276
Opioids 276
Antiinfective Agents 276
Amoxicillin 276
Erythromycin 279
Cephalosporins 279
Tetracyclines 279
Clindamycin 279
Metronidazole 279
Nystatin 279
Clotrimazole 279
Ketoconazole 279
Antianxiety Agents 279
Nitrous Oxide-Oxygen Mixture 279
Benzodiazepines 279
Alcohol 280
Dental hygiene considerations 280
Academic skills assessment 281
Clincial case study 281
Chapter 26: Drug Abuse 282
General considerations 283
Definitions 283
Psychological Dependence 283
Physical Dependence 283
Tolerance 283
Addiction, Habituation, and Dependence 283
Central nervous system depressants 284
Ethyl Alcohol 284
Pharmacokinetics 284
Acute Intoxication 284
Withdrawal 284
Long-Term Effects 284
Alcoholism 285
Treatment 285
Dental Treatment of the Alcoholic Patient 286
Nitrous Oxide 287
Abuse Pattern 287
Adverse Reactions 288
Opioid Analgesics 288
Pattern of Abuse 288
Management of Acute Overdose and Withdrawal 288
Dental Implications 289
Opioid Street Drugs 289
Sedative-Hypnotics 289
Pattern of Abuse 289
Management of Acute Overdose and Withdrawal 290
Central nervous system stimulants 290
Cocaine 290
Amphetamines 290
Pattern of Abuse 290
Management of Acute Overdose and Withdrawal 291
Caffeine 291
Tobacco 291
Nicotine 291
Pattern of Abuse 291
Smokeless Tobacco 292
Management and Withdrawal 292
Bupropion 292
Varenicline 292
The Dental Hygienist’s Role in Tobacco Cessation 292
Psychedelics (hallucinogens) 292
Lysergic Acid Diethylamide 292
Phencyclidine 293
Marijuana 293
Medical Marijuana 293
Synthetic Marijuana 293
Identifying the drug abuser 293
The impaired dental hygienist 294
Dental hygiene considerations 294
Academic skills assessment 294
Clinical case study 294
Chapter 27: Natural/Herbal Products and Dietary Supplements 295
Limited regulation 296
Dietary Supplement Health and Education Act 296
Package Labeling 296
Safety of herbal and nutritional products 296
Oral Adverse Effects 297
Drug interactions 297
Standardization of herbal products 298
Good manufacturing practice 299
Herbal supplements used in oral health care 299
Acemannan 299
Essential Oil Mouth Rinse 299
Oil of Cloves (Eugenol) 299
Triclosan 299
Xylitol 300
Reference 300
Dental hygiene considerations 300
Academic skills assessment 300
Clinical case study 300
Appendix A: Compilation of the Top 200 Products of 2012 by Total Prescriptions 302
Appendix B: Medical Acronyms 307
Appendix C: Medical Terminology 311
Appendix D: What If … 313
What if … the patient is pregnant? * 313
What if … the patient is allergic to aspirin? 313
What if … the patient is allergic to penicillin? 314
What if … the patient is allergic to sulfites? 314
What if … the patient is allergic to codeine? 315
What if … the patient is allergic to latex? 315
What if … the cardiac patient needs antibiotics? (See chapter 7) 316
What if …the patient with primary total joint replacement needs antibiotics? (See chapter 7) 317
What if … the patient is taking warfarin (Coumadin)? (See chapter 14) 317
Appendix E: Oral Manifestations: Xerostomia and Taste Changes 318
Appendix F: Children’s Dose Calculations 321
Calculation of children’s dose 321
Clark’s Rule 321
Fried’s Rule 321
Young’s Rule 321
Cowling’s Rule 321
Surface Area Rule 321
Discussion 321
Example 321
Appendix G: Photo Credit Listing 322
Glossary 323
Drug Index 333
Index 343