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Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease E-Book

Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease E-Book

Deepak L. Bhatt

(2015)

Additional Information

Book Details

Abstract

Introducing Cardiovascular Intervention, a comprehensive companion volume to Braunwald’s Heart Disease. This medical reference book contains focused chapters on how to utilize cutting-edge interventional technologies, with an emphasis on the latest protocols and standards of care. Cardiovascular Intervention also includes late-breaking clinical trials, "Hot off the Press" commentary, and Focused Reviews that are relevant to interventional cardiology.

  • View immersive videos from an online library of procedural clips located on Expert Consult.
  • Remain abreast of the newest interventional techniques, including next-generation stents, invasive lesion assessment, and methods to tackle complex anatomy.
  • Provide optimal patient care with help from easy-to-access information on the latest diagnostic and treatment advances, discussions on percutaneous approaches to structural heart disease, and new developments in treating heart valve disease.

Table of Contents

Section Title Page Action Price
Front Cover cover
Endsheet 2 IFC2
Cardiovascular Intervention i
Copyright Page iv
Dedication v
List of Contributors vii
Foreword xi
Preface xiii
Acknowledgments xv
Table Of Contents xvii
Video Contents xix
Look for These Other Titles in the Braunwald’s Heart Disease Family xxiii
Braunwald’s Heart Disease Companions xxiii
Braunwald’s Heart Disease Review and Assessment xxv
Braunwald’s Heart Disease Imaging Companions xxv
Coming Soon! xxv
I Interventional Cardiology 1
1 The Birth of Interventional Cardiology 1
The Innovator of Angioplasty 1
The First Peripheral Arterial Angioplasty 2
The Development of Coronary Angioplasty 2
Coronary Angioplasty Then and Now 3
Acute Angioplasty Failure 3
Mechanism of Balloon Angioplasty 4
Dissemination of Coronary Angioplasty 4
Andreas Grüntzig, the Man 4
Development of Interventional Cardiology and Minimally Invasive Surgery 5
Acknowledgment 5
References 5
2 Guidelines and Appropriateness Criteria for Interventional Cardiology 7
Introduction 7
Practice Guidelines 7
Guideline Development 7
Guidelines for ST-Elevation Myocardial Infarction 8
Guidelines for Unstable Angina/Non–ST-Elevation MI 10
Guidelines for Stable Ischemic Heart Disease 12
Appropriateness Criteria 13
Development Process 13
Summary of Recommendations for Coronary Revascularization 13
Other Methods to Improve Quality 17
Performance Measures 17
Public Reporting 18
Putting Guidelines into Practice 18
Conclusions 18
References 18
3 Vascular Access and Closure 20
Femoral Arterial Access 20
Introduction 20
Anatomic Considerations 20
Preprocedural Considerations 21
Procedure 22
Special Considerations 22
Using a Micropuncture Needle 22
Using a SmartNeedle Percutaneous Doppler Vascular Access Device 23
Using Ultrasound Guidance 23
Femoral Arterial Cannulation in a Challenging Patient Subgroup 24
Morbidly Obese Patients 24
Patients with Ilio-femoral Bypass Grafts 24
Patients with Calcified Femoral Artery 25
Postprocedure Care 25
Complications 25
Bleeding/Hematoma 25
Retroperitoneal Hemorrhage 25
Arteriovenous Fistula 26
Pseudoaneurysm 27
Artery Occlusion 27
Dissection 27
Femoral Neuropathy 27
Groin Site Infection 28
Femoral Arterial Access Site Closure 30
Introduction 30
Manual Compression 30
Mechanical Compression 30
Assisted Compression Devices/Topical Hemostasis Accelerators 32
Vascular Closure Device 32
Collagen-Plug-Based Devices—Angio-Seal 34
Collagen-Plug-Based Devices—Mynx 35
Suture-Mediated Closure Devices 36
Clip-Based Device—StarClose 37
Radial Arterial Access and Closure 37
Introduction 37
Anatomic Considerations 39
Preprocedural Considerations 39
Modified Allen Test 39
Barbeau Test 40
Procedural Considerations 42
Positioning 43
Conscious Sedation and Local Anesthesia 43
Technique 43
Closure and Postprocedural Care 43
Closure 43
Postprocedure Care 45
Complications and Challenges 45
Radial Artery Occlusion 45
Access Failure 45
Perforation 45
Hematoma 47
Compartment Syndrome 47
Radial Artery Pseudoaneurysm (Figure 3-34) 47
Radial Arteriovenous Fistula 48
Sterile Granuloma 48
Radial Artery Avulsion 48
Ulnar Arterial Access and Closure 48
Brachial Arterial Access and Closure 49
Introduction and Anatomy 49
II Coronary Artery Intervention 115
8 Percutaneous Coronary Intervention for Unprotected Left Main Disease 115
Introduction 115
Randomized Controlled Trials 115
Metaanalyses 117
Ongoing Trials 118
Current Guidelines and Appropriate use Criteria 118
Scoring Algorithms 119
Impact of Stent Choice 120
In-Stent Restenosis 120
Disease Location: Ostial/mid-Shaft versus Distal LM 120
One-Stent versus Two-Stent Approach for LM Bifurcation Disease 121
Two-Stent Techniques 123
Dedicated Bifurcation Stents 123
Importance of Final Kissing Balloon Inflation 123
Role of Imaging 124
Intravascular Ultrasound 124
Fractional Flow Reserve 125
Myocardial Infarction due to LM Thrombosis 125
Hemodynamic Support 126
Dual Antiplatelet Therapy Selection and Duration 126
Follow-Up after Left Main PCI 126
Left Main Bifurcation PCI Techniques 126
Provisional Stent Technique (Figure 8-6 and Video 8-1) 126
Two-Stent Techniques 128
Description of Techniques 128
Culotte Technique (Figure 8-7 and Video 8-2) 128
Crush Techniques (Figure 8-8 and Video 8-3) 129
T-Stent Techniques (Figure 8-10 and Video 8-5) 130
V-Stent Technique (Figure 8-11 and Video 8-6) 130
Ostial LM PCI 131
Conclusions 131
References 136
9 Chronic Total Coronary Occlusions: 138
Introduction 138
Anatomic Considerations 138
Histopathology of CTOs 139
Collaterals and CTOs 139
Target Vessel 140
Indications 140
Angina and Quality of Life 141
Improvement in Left Ventricular Dysfunction 142
Reduction in Arrhythmic Events 143
Improved Tolerance of Ischemic Events 143
Survival and Completeness of Revascularization 144
Procedural Outcomes and Fundamentals 144
Predictors of Procedural Outcome 144
Vascular Access, Equipment Selection, and Angiography 145
Guidewires and Microcatheters 146
Procedural Antithrombotic Therapy 146
Technical Strategies 147
Traditional Antegrade Techniques 147
Antegrade Device-Assisted Dissection Reentry Technique 147
Retrograde Techniques: CART and Reverse CART 147
Hybrid Technique 149
Imaging: Computed Tomographic Angiography and Intravascular Ultrasound 150
Stent Selection for CTO Revascularization 150
Clinical Rationale for Drug-Eluting Stents in Percutaneous Revascularization of Coronary Occlusions 150
Contemporary DES Trials in CTO Revascularization 151
Limitations 152
CTO Complications 152
Conclusions 152
References 153
10 Bifurcations 155
Introduction 155
Simplified Guidelines After 10 Years of Bifurcation Studies 156
Provisional Approach Is the Default Strategy 156
Two Stents Can Be Selectively Implanted As Intention to Treat or Crossover from Provisional 158
Residual SB Stenosis After the Provisional Approach Is Often Not Significant 159
Kissing Balloon Inflation or High-Pressure Individual (SB & MB) Postdilatation Should Always Be Used When Implanting Two Stents and Optionally When Implanting One Stent 160
Optimal Technique Is a Must, Especially When Two Stents Have Been Implanted 162
Stent Thrombosis After Bifurcation PCI 162
An Individualized Approach to Bifurcations 162
Technical Aspects of Bifurcation PCI 163
General Aspects 163
Guide Catheter 163
Vascular Access 163
Wiring Both Branches of the Bifurcation and Jailed Guidewires 163
Difficult SB Access 164
Provisional Approach 164
Proximal Optimization Technique (POT) 165
Final Kissing Balloon Inflation (FKBI) 165
Technical Tips for Provisional Approach 165
Crossover to Double Stenting from a Provisional Approach 165
T Technique 166
T-Stenting and Small Protrusion (TAP) 166
Reverse Crush 166
Provisional Culotte 167
Elective Double Stenting 167
Selecting a Double Stenting Technique 168
Double Stenting Technique Description 171
The Culotte Technique 171
The Minicrush Technique (SB Stent Crushed by the MB Stent) 174
Double-Kissing Minicrush (DK Crush) 177
T and Modified T Techniques 178
Modified T Technique 178
The V and the Simultaneous Kissing Stent (SKS) Techniques 178
Final Kissing Inflation (FKBI) after Double Stenting 180
Difficult Access to the SB or MB after Stenting 180
Ancillary Devices and Procedures 180
Intravascular Ultrasound (IVUS) 180
Lesion Preparation: Role of Debulking 181
Drug-Eluting Balloons in Bifurcations 181
Dedicated Bifurcation Stents 181
Bioresorbable Scaffolds (BRS) in Bifurcations 182
Conclusions 182
References 182
11 Bypass Graft Interventions 184
Introduction 184
Epidemiology 184
Indications for Bypass Graft Interventions 184
Distal Embolization and Embolic Protection Devices 184
SVG Stenting 191
Adjunctive Pharmacotherapy 191
Technical Aspects of SVG PCI 192
Intravascular Imaging 192
SVG Engagement 192
Acutely Occluded SVGs 193
Chronically Occluded SVGs 193
Intermediate SVG Lesions 193
SVG PCI Complications 193
Arterial Graft Interventions 193
Conclusions 196
Acknowledgment 196
References 196
12 Calcified Lesions 199
Introduction 199
Percutaneous Transluminal Rotational Atherectomy 199
Procedural Details 199
Clinical Studies of Rotational Atherectomy 201
Summary 201
Orbital Atherectomy 202
Procedural Details 202
Clinical Studies of Orbital Atherectomy 202
Summary 203
Scoring Balloon Angioplasty (SBA) 203
Clinical Studies of Scoring Balloon Angioplasty 204
Summary 205
Excimer Laser Atherectomy 205
Procedural Details 205
Clinical Studies of Excimer Laser Atherectomy 206
Summary 206
Conclusions 206
References 207
13 Treatment of In-Stent Restenosis 209
Introduction 209
Mechanisms of In-Stent Restenosis 210
Balloon Angioplasty 210
Plaque Debulking With Atherectomy 212
Cutting and Scoring Balloon Angioplasty 213
Vascular Brachytherapy 214
Bare-metal Stenting 215
Drug-Eluting Stenting 215
Restenosis Within Bare-metal Stents 216
Restenosis Within Drug-Eluting Stents 216
Bioresorbable Stents 217
Drug-Coated Balloon Angioplasty 217
Restenosis Within Bare-Metal Stents 217
Restenosis Within Drug-Eluting Stents 218
Coronary Bypass Surgery 219
Role of Intravascular Imaging 219
Additional Considerations 219
Bioresorbable Stent Failure 219
Conclusions 220
References 221
14 Management of Thrombotic Lesions 223
Introduction 223
Stent Thrombosis 223
Pharmacological Strategies to Improve Myocardial Perfusion 223
Mechanical Strategies to Improve Myocardial Perfusion 224
Currently Approved Devices 224
Case 225
Potentially Useful Devices 225
Devices That Are Not Used 227
Clinical Trial Data 227
Aspiration Thrombectomy 227
Rheolytic Thrombectomy and Distal Embolic Protection 227
Infusion Catheter 227
Guideline Recommendations 228
Conclusions 228
References 228
15 Fractional Flow Reserve 229
Introduction 229
Rationale for In-Lab Coronary Physiologic Measurements 229
Derivation of Fractional Flow Reserve from Coronary Pressure Measurements 231
Coronary Flow Reserve versus Fractional Flow Reserve 232
Fractional Flow Reserve and Myocardial Bed Size 232
Techniques of Intracoronary Pressure Sensor Wire Measurement 233
Pharmacologic Coronary Hyperemia 234
Adenosine 234
Regadenoson 234
Alternative Hyperemic Agents 235
Precautions and Pitfalls of Fractional Flow Reserve 235
Safety of Intracoronary Sensor Wire Measurements 236
Validation and Threshold of Ischemia 236
Use of Fractional Flow Reserve for Specific Angiographic Subsets 236
The Intermediate Coronary Lesion 236
Fractional Flow Reserve in Multivessel Disease 237
Fractional Flow Reserve After Percutaneous Coronary Intervention 239
Left Main Stenosis 239
Complex Left Main Lesion Assessment (LM Plus Downstream Lesions) with Fractional Flow Reserve 239
Fractional Flow Reserve and Small-Vessel Disease 240
Serial (Multiple) Lesions in a Single Vessel 240
Practical Technique of Serial Lesion Assessment 242
Diffuse Coronary Disease 242
Ostial and Side Branch Lesions 242
Saphenous Vein Graft Lesions 242
Fractional Flow Reserve in Acute Coronary Syndrome 245
Intravascular Ultrasound and Fractional Flow Reserve in Lesion Assessment 245
Fractional Flow Reserve and Intravascular Ultrasound Comparisons for Non–Left Main Coronary Artery Stenosis 247
Assessing Collateral Flow 247
Index of Microcirculatory Resistance 248
Economics of Physiologic Guided Interventions 248
Conclusions 249
References 250
16 Intravascular Ultrasound Imaging 252
Background and Limitations of Angiography 252
IVUS Imaging, Basic Image, and Measurements 253
Guidelines for Use and Appropriate Indications 256
Diagnostic Applications 256
Ambiguous Angiograms and Indeterminate Coronary Lesions 256
Evaluation of the Left Main Coronary Artery 258
Evaluation of Transplant Vasculopathy 260
Interventional Applications 260
Vessel Sizing 260
IVUS Imaging in Coronary Stenting 260
Bare-Metal Stents 261
Drug-Eluting Stents 262
Strut Malapposition 264
Management of Stent Restenosis 265
Assessment of Complications After Intervention 265
Advanced Applications of IVUS Imaging in Chronic Total Occlusion Angioplasty 267
IVUS Imaging in the Peripheral Arterial System 267
Research Applications—Progression/Regression Trials 269
Advancing IVUS Technologies and Future Directions 270
IVUS-Derived Virtual Histology 270
IVUS and Near Infrared Spectroscopy (NIRS) 272
IVUS and OCT Imaging 272
Future Directions 273
Conclusions 274
Acknowledgment 274
References 274
17 Optical Coherence Tomography 276
Introduction 276
Physics of Optical Coherence Tomography 276
Image Acquisition by Optical Coherence Tomography 277
Time Domain Optical Coherence Tomography 277
Frequency Domain Optical Coherence Tomography 278
Potential Risks and Complications 278
Evaluation of Coronary Pathology 278
Normal Artery 278
Lipid Plaque 279
Fibrous and Fibrocalcific Plaque 279
Intraluminal and Intramural Pathology Seen by Optical Coherence Tomography 279
Macrophages 279
Cholesterol Crystal 280
Microchannels 280
Thrombus 280
Others 280
Thin-Cap Fibroatheroma 280
Pitfalls of Image Interpretation 281
Optical Coherence Tomography Imaging Artifacts 281
Assessment of Coronary Plaque Characteristics 282
Clinical Presentations and Plaque Morphology 282
Etiology of Acute Coronary Syndrome 282
Acute Myocardial Infarction at Rest versus with Exercise 283
Role of Optical Coherence Tomography In Percutaneous Coronary Intervention 283
Pre-stent Deployment 283
Immediate Post-stent Deployment 284
Bifurcation Intervention 285
Clinical Benefit of Optical Coherence Tomography–Guided Percutaneous Coronary Intervention 285
Late Stent Evaluation 285
Assessment of Non–Coronary Artery Pathology 287
Pulmonary Hypertension 287
Peripheral Vascular Disease 287
Transplant Vasculopathy 287
Future Directions 287
Multimodality Systems 287
Three-Dimensional Optical Coherence Tomography 287
Micro-optical Optical Coherence Tomography 287
Conclusion 288
References 288
III Peripheral Artery Intervention 291
18 Intervention for Lower Extremity Arterial Disease 291
Clinical Assessment 291
Causes of Peripheral Artery Disease 291
Acute Limb Ischemia 291
Chronic Limb Ischemia 293
Physical Exam 293
Physiological Tests 293
Arterial Imaging 293
Percutaneous Revascularization Tools 294
Approach and Access 294
Guides and Sheaths 295
Wires 297
Anticoagulation 297
Reentry Devices 297
Other Chronic Total Occlusion (CTO) Devices 299
Balloon Angioplasty 300
Drug-Eluting Balloons 301
Stents 301
Covered Stents 302
Drug-Eluting Stents 302
Atherectomy 302
Other Plaque-Modifying Technologies 303
Brachytherapy 304
Catheter-Based Thrombolysis 304
Intravascular Imaging 305
Interventions in Specific Arteries 308
Aorto-iliac Interventions 308
Superficial Femoral Artery 309
Popliteal Artery 309
Tibial Arteries 310
Venous and Prosthetic Graft Interventions 310
Conclusions 310
References 312
19 Upper Extremity Intervention 314
Introduction 314
Diagnosis and Clinical Syndromes 314
Treatment 315
Surgical Revascularization 315
Endovascular Therapy 316
Interventional Technique 316
Conclusions 318
References 319
20 Renal Artery Intervention: 321
Introduction 321
Diagnosis 321
Screening for Renal Artery Stenosis 321
Duplex Ultrasonography 321
Resistive Index 322
Noninvasive Angiography 322
Invasive Angiography 323
Translesional Pressure Gradients 323
TIMI Frame Count 323
Renal Artery Intervention 323
Technique for Renal Artery Intervention 324
Renal Artery Atherosclerotic Lesions 324
Fibromuscular Dysplasia 325
Procedural Complications 325
Embolus Protection Devices 325
Radial Artery Access 325
Renal Artery In-Stent Restenosis 326
Asymptomatic Renal Artery Stenosis 326
Renovascular Hypertension 326
Clinical Characteristics 326
Prevalence 326
Epidemiology 327
IV Cerebrovascular Intervention 377
24 Carotid and Vertebral Intervention 377
Carotid Intervention 377
The Data 377
The Procedure 382
Lesion Considerations 385
Access 386
Embolic Protection 388
Stent 389
Balloon Dilation 391
Hemodynamic Management 392
Neurological Management 393
Pharmacology 394
Conclusions 394
References 394
25 Intracranial Intervention and Acute Stroke 396
Introduction 396
Cerebrovascular Disease 396
Epidemiology 396
Clinical Manifestations 396
Diagnostic Evaluation 397
The Cerebral Vasculature 397
Acute Ischemic Stroke Treatment 397
Techniques 399
Intraarterial Thrombolysis 399
Combined IV/IA Thrombolysis 400
Mechanical Embolectomy 400
Balloon Angioplasty and Stenting 402
Clinical Outcomes 402
Peri-procedural Management 404
Ischemic Stroke Prevention 404
Intracranial Angioplasty and Stenting 404
Indications and Patient Selection 404
Clinical Manifestation 405
Techniques 405
Clinical Outcomes 407
Conclusions 408
References 408
V Venous Intervention 411
26 Interventional Management of Lower Extremity Deep Vein Thrombosis and Pulmonary Embolism 411
Introduction 411
Section 1: Lower Extremity Deep Vein Thrombosis 411
Acute Deep Vein Thrombosis 411
Epidemiology and Pulmonary Embolus Prevention 411
IVC Filters 411
The Post-Thrombotic Syndrome 412
Preventing the Post-Thrombotic Syndrome: Beyond Anticoagulation 413
Endovascular Thrombus Removal Techniques 413
Patient Selection (Table 26-1) 415
Outcomes and Data (Table 26-2) 415
Chronic Deep Vein Thrombosis 415
Patient Workup 415
Noninterventional Management of PTS 416
Endovascular Intervention in the Setting of Established PTS 416
Interventional Techniques to Recanalize Post-Thrombotic Deep Veins 416
Complications and Outcomes 418
Section 2: Acute Pulmonary Embolism 419
Epidemiology and Classification 419
Treatment Escalation for Massive Pulmonary Embolism 419
Treatment Escalation for Submassive Pulmonary Embolism 420
Patient Follow-Up 420
Conclusions 421
References 421
27 Management of Chronic Venous Insufficiency 423
Epidemiology and Risk Factors of Chronic Venous Disease 423
Venous Anatomy and Physiology 424
Superficial Veins of the Lower Limb 424
Great Saphenous Vein 424
Anterior Accessory Saphenous Vein 425
Posterior Accessory Saphenous Vein 425
Small Saphenous Vein (SSV) 425
Perforators of the Lower Limb 426
Deep Venous System 427
Physiology of the Venous System 428
Etiology and Pathophysiology of Chronic Venous Insufficiency 428
Evaluation and Classification of the Patient with Chronic Venous Insufficiency 429
Anatomic and Physiologic Testing of Chronic Venous Insufficiency 430
Duplex Venous Ultrasound of the Lower Limb 430
Plethysmography 432
Treatment of Superficial Chronic Venous Insufficiency 432
Compression Therapy 433
Endovascular Heat Ablative Therapies 433
Endovascular Laser Ablation 434
Endovascular Radiofrequency Ablation 434
Steam Ablation 435
Nonthermal Ablative Therapies 435
Sclerotherapy 435
Catheter-Assisted Balloon Sclerotherapy 436
ClariVein or Mechanochemical Endovenous Ablation 436
Cyanoacrylate Adhesive 437
Phlebectomy 437
Surgical Vein Stripping 437
Pharmacologic Management of Chronic Venous Insufficiency 437
Endovascular Management of Venous Ulcerations 438
Deep Venous Valves 438
Conclusions 439
References 439
28 Hemodialysis Access Intervention 442
Introduction 442
Epidemiology and Prevalence of Stage V Kidney Disease 442
Survival 442
Hemodialysis 442
Vascular Anatomy 442
Nomenclature 442
Autogenous Arteriovenous Accesses 442
Prosthetic Arteriovenous Accesses 443
Anatomic Variants 443
Pathogenesis of Access Failure 444
Failure to Mature 444
Stenosis Development in Mature Accesses, with or without Thrombosis 444
Diagnostic Evaluation 445
Monitoring 445
Surveillance 445
Diagnostic Testing 445
Catheter-Based Treatment of Failing Accesses 445
Indications 445
4-Step Procedure for Thrombosed Accesses 446
Thrombectomy 446
Angioplasty, Stenting, or Stent-Grafting of Stenosis 447
Fogarty Embolectomy 447
Central Venous Angiography 447
Outcomes 448
Success Rates 448
Complications 448
Newer Approaches 448
Stent Grafts 448
Interventional Nephrology 448
Pre-emptive Angiography 449
Salvage of Hypoplastic Fistulas 449
Conclusions 449
References 449
VI Structural Heart Intervention 451
29 Aortic Valvuloplasty and Transcatheter Aortic Valve Replacement 451
Introduction 451
Balloon Aortic Valvuloplasty 451
Procedural Considerations 451
Outcomes 452
Indications 452
Next Generation BAV Devices 453
Transcatheter Aortic Valve Replacement (Implantation)— General Concepts 453
Historical Perspectives and Unmet Clinical Need 453
Clinical Indications 454
Heart Team Model and Risk Assessment 454
Anatomic Screening and Need for Multimodality Imaging 454
Procedural Considerations 455
Balloon Expandable Valves 455
Technology Overview and Early Access Approaches 455
Procedural Details for Sapien or Sapien XT Implantation 456
Alternative Access Approaches 456
Early Feasibility Trials 458
SOURCE and Other Registries 458
The PARTNER Trial 461
Self-Expanding Valves 467
Technology Overview 467
Procedural Details for CoreValve Implantation 468
Alternative Access Approaches 468
Overview of Registry Data and ADVANCE 469
CoreValve US Pivotal Trial 469
“Real-World” Registries and Other Studies (Choice and TVT Registry) 471
New Clinical Indications 472
Bioprosthetic Valve Failure 472
Moderate-Risk Patients 473
TAVR for Bicuspid Aortic Valve 473
TAVR for Native Aortic Valve Regurgitation 473
Complications of TAVR 474
Stroke 474
Paravalvular Regurgitation 474
Conduction Abnormalities and Arrhythmias 475
Vascular Complications and Bleeding 476
Other Less Frequent Complications 476
New TAVR Devices 477
Overview 477
Self-Expanding TAVR Systems 477
Other TAVR Concepts 477
Future Directions 478
Conclusions 478
References 478
30 Transcatheter Mitral Valve Intervention 482
Section I: Mitral Stenosis 482
Introduction 482
Normal Mitral Valve Anatomy 482
Mitral Valve Disease States: Mitral Stenosis 482
Etiologies of Mitral Stenosis 482
Pathology of Rheumatic Mitral Stenosis 483
Pathophysiology of Rheumatic Mitral Stenosis 483
Clinical Presentation of Mitral Stenosis 483
Clinical Manifestations 483
Clinical Assessment 484
History and Physical Examination 484
Clinical Assessment with Diagnostic Tools 484
Echocardiography 484
Cardiac Catheterization and Angiography 485
Management of Mitral Stenosis 485
Medical Therapy for Mitral Stenosis 485
Catheter-Based Treatment of Mitral Stenosis 487
Indications for Catheter-Based Treatment 487
Patient Selection 487
Procedure 487
Transseptal Catheterization 487
Inoue Technique 489
Double Balloon Technique 490
Results 490
Procedural Imaging 491
Special Considerations—Pregnancy 491
Section II: Mitral Regurgitation 491
Pathophysiology 491
Rationale for Transcatheter Therapy 491
Leaflet Repair with the MitraClip Device 491
Indirect Annuloplasty 493
Direct Annuloplasty and Left Ventricular Remodeling Techniques 494
Transcatheter Mitral Valve Replacement 495
Conclusions 496
References 497
31 Hypertrophic Cardiomyopathy 498
Introduction and Epidemiology 498
Hallmarks and Differential Diagnosis 498
Natural Course of Disease and Clinical Presentation 499
Pathophysiology 499
Left Ventricular Outflow Tract Obstruction 499
Diastolic Dysfunction 501
Myocardial Ischemia 501
Autonomic Dysfunction 501
Mitral Regurgitation 502
Myocardial Fibrosis 503
Genetics and Role of Genetic Testing 503
Diagnosis 504
Echocardiography 504
Electrocardiography 505
Stress Testing 505
Cardiac Magnetic Resonance Imaging 505
Invasive Hemodynamic Assessment 505
Management of HCM 507
Asymptomatic Patients 507
Symptomatic Patients 507
Medical Management 507
Beta-Blockers 507
Calcium Channel Blockers 507
Disopyramide 508
Amiodarone 508
Other Agents 508
Invasive Management 508
Septal Myectomy 509
Patient Selection. 509
Early Results. 509
Late Results. 509
Complications. 510
Important Considerations. 510
Alcohol Septal Ablation 510
Patient Selection. 510
Procedural Technique (Video 31-1). 510
Results. 513
Complications. 514
Comparison of Alcohol Septal Ablation and Septal Myectomy 514
Role of Dual Chamber Pacing 514
Management of Atrial Fibrillation 514
Management of Systolic Dysfunction 515
Role of Heart Transplantation 515
Prevention of Sudden Cardiac Death 515
Participation in Competitive Sports 515
Role of ICD Implantation 516
Conclusions 516
References 516
32 Patent Foramen Ovale, Atrial Septal Defect, Left Atrial Appendage, and Ventricular Septal Defect Closure 519
Patent Foramen Ovale 519
Introduction 519
Developmental Anatomy of the Atrial Septum (Figure 32-1) 519
Clinical Presentation 520
Diagnosis 521
Management 521
Medical Therapy 521
Transcatheter Patent Foramen Ovale Closure 522
Randomized Trials of Patent Foramen Ovale Closure for Cryptogenic Stroke 522
Indications for Transcatheter Patent Foramen Ovale Closure 523
Devices 523
Amplatzer Devices 523
Helex Device 524
Procedural Details 524
Postprocedure Care 526
Complications 526
ASD Closure 526
Introduction 526
Anatomy 526
Pathophysiology 527
Clinical Presentation 527
Diagnosis 527
Cardiac Catheterization 527
Management and Indications for Atrial Septal Defect Closure 527
Devices for Atrial Septal Defect Closure 528
Procedural Details 529
Postprocedure Care 530
Large Atrial Septal Defect with Deficient Rims 530
Multiple or Fenestrated Defects 531
Complications 531
Clinical Trial Data 532
Left Atrial Appendage Closure 532
Introduction 532
Medical Therapy for Stroke Prevention in Atrial Fibrillation 532
Left Atrial Appendage Anatomy 532
Surgical Left Atrial Appendage Exclusion 532
Percutaneous Left Atrial Appendage Closure 532
Imaging for Left Atrial Appendage Closure 532
PLAATO Device 533
Watchman Device 533
Procedure 533
Data for Watchman Device 534
Amplatzer Cardiac Plug 534
Data for Amplatzer Cardiac Plug Device 534
LARIAT Device 535
Next Generation Left Atrial Appendage Closure Devices 535
Watchman Generation 5 535
Amulet 535
Coherex 535
Ventricular Septal Defect 535
Introduction 535
Anatomy 535
Pathophysiology 536
Clinical Presentation 536
Diagnosis 536
Management and Indications for Ventricular Septal Defect Closure 536
Devices for Transcatheter Ventricular Septal Defect Closure 537
Contraindications for Closure (Muscular Ventricular Septal Defect) 537
Procedural Details (Muscular Ventricular Septal Defect) 537
Complications 538
Clinical Trial Data 538
Post-Myocardial Infarction Ventricular Septal Defect 538
Management 539
Transcatheter Post-Myocardial Infarction Ventricular Septal Defect Closure 539
Conclusions 540
References 541
33 Interventions for Advanced Heart Failure 543
Introduction 543
Defining Advanced Heart Failure 543
Hemodynamics of Heart Failure 544
Percutaneous Mechanical Circulatory Support 545
Intra-aortic Balloon Pump Counterpulsation 546
Percutaneous Rotodynamic Pumps 548
Circulatory Support for Cardiogenic Shock and Advanced Heart Failure 551
Interventional Therapy for Right Heart Failure 551
Emerging Percutaneous Circulatory Support Devices 554
Percutaneous Coronary Intervention (PCI) in the Heart Failure Patient 554
Valvular Interventions in Advanced Heart Failure 556
Transcatheter Aortic Valve Replacement in Advanced Heart Failure 556
Percutaneous Approaches for Functional Mitral Regurgitation 557
Emerging Interventional Approaches for Heart Failure 557
Percutaneous Ventricular Volume Reduction 557
Interventions for Heart Failure With Preserved Ejection Fraction 558
Invasive Approaches for Patients Requiring Left Ventricular Assist Device Support 558
Conclusions 559
References 559
34 Endomyocardial Biopsy 562
Introduction 562
Development of the Procedure—A Historic Perspective 562
Technique of the Procedure 563
Safety of Endomyocardial Biopsy 564
Processing Endomyocardial Tissue Specimens 566
Indications for Endomyocardial Biopsy 566
Utility of Endomyocardial Biopsy in Cardiac Transplant Allografts 569
Expert Practice Summary 570
Conclusions 570
References 570
35 Pericardiocentesis and Pericardial Intervention 572
Introduction 572
The Normal Pericardium 572
Pericardial Effusion and Tamponade 573
Clinical Diagnosis of Pericardial Tamponade 573
Indications for Pericardiocentesis 574
Pericardiocentesis Technique 574
PostPericardiocentesis Catheter Management 575
Complications of Pericardiocentesis 576
Malignant, Recurrent, or Persistently Draining Pericardial Effusions 576
Technique of Single Balloon Percutaneous Balloon Pericardiotomy 577
Technique of Double Balloon Percutaneous Balloon Pericardiotomy 578
Outcomes after Percutaneous Balloon Pericardiotomy 579
Percutaneous Pericardial Biopsy 579
Technique of Percutaneous Pericardial Biopsy 580
Role of Pericardioscopy 580
Percutaneous Epicardial Access for Electrophysiology Studies and Ablation 581
Technique of Pericardial Access and Epicardial Mapping and Ablation 581
Limitations and Potential Complications of Pericardial Access and Epicardial Ablation 582
Percutaneous Pericardial Access for Transcatheter Left Atrial Appendage Ligation 582
Preprocedural Considerations 583
Technique of Percutaneous Transpericardial Left Atrial Appendage Exclusion 583
Procedural Complications 585
Conclusions 586
References 586
VII Congenital Heart Disease 589
36 Congenital Heart Disease 589
Introduction 589
Catheter-Based Interventions for Congenital Heart Disease 589
Coarctation of the Aorta—Native or Restenosis for Intervention 589
Arteriovenous Fistulae or Malformations 591
Coronary Artery Fistulae 591
Pulmonary Arteriovenous Malformations 592
Anomalous Venovenous Connections Causing Systemic Hypoxemia 593
Valvular Heart Disease Secondary to Congenital Etiology 594
Pulmonary Valvuloplasty 594
Transcatheter Pulmonary Valve Placement 594
Aortic Valve 596
Pulmonary Hypertension in Congenital Heart Disease 597
Overview 597
Eisenmenger Syndrome/Secondary Pulmonary Hypertension 597
Future Directions 597
Covered Stent Technology 597
Investigational Transcatheter Pulmonary Valve Technology 598
Conclusions 599
Acknowledgment 599
References 599
Index 601
A 601
B 603
C 604
D 607
E 607
F 608
G 609
H 609
I 610
J 612
K 612
L 612
M 613
N 614
O 614
P 615
Q 617
R 617
S 618
T 620
U 621
V 621
W 622
X 622
Y 622
Endsheet 7 IBC7