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Book Details
Abstract
The 5th edition of this classic text sets the standard for comprehensive coverage of immunology. Building from a solid foundation of knowledge and skills, trusted author Mary Louise Turgeon takes you from basic immunologic mechanisms and serologic concepts to the theory behind the procedures you’ll perform in the lab. Immunology & Serology in Laboratory Medicine, Fifth Edition is the go-to resource for everything from mastering automated techniques to understanding immunoassay instrumentation and disorders of infectious and immunologic origin. Packed with learning objectives, review questions, step-by-step procedures, and case studies, this text is your key to succeeding in today’s modern laboratory environment.
- Full-color, six-page insert of photomicrographs provide a better picture of what you’ll see in the laboratory.
- Learning objectives at the beginning of each chapter offer a measurable outcome you can achieve by completing the material.
- Chapter highlights at the end of each chapter provide a summary of the most important information covered in each chapter.
- Review questions at the end of each chapter are tied to learning objectives further enhance your understanding.
- Case studies challenge you to apply your knowledge and help strengthen your critical thinking skills.
- Glossary at the end of the book provides quick access to key terms and definitions.
- NEW! Expanded chapter on Vaccines as the importance of vaccines continues to become more evident.
- NEW! Updated chapter on Molecular Techniques incorporates the newest technology specific to immunology.
- NEW! Key terms at the beginning of each chapter help you learn the important vocabulary in immunology.
- NEW! Case studies with added multiple-choice questions in addition to critical thinking questions will help you apply your knowledge and develop critical-thinking skills.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Evolve Page | ii | ||
| Immunology & Serologyin Laboratory Medicine | iii | ||
| Copyright | iv | ||
| Dedication | v | ||
| Reviewers | vii | ||
| Contributors | ix | ||
| Preface | xi | ||
| Acknowledgments | xiii | ||
| About The Author | xiv | ||
| Contents | xv | ||
| PART I - Basic Immunologic Mechanisms | 1 | ||
| Chapter 1 - An Overview of Immunology | 1 | ||
| HISTORY OF IMMUNOLOGY | 2 | ||
| WHAT IS IMMUNOLOGY? | 2 | ||
| CELLS OF THE IMMUNE SYSTEM | 2 | ||
| FUNCTION OF IMMUNOLOGY | 3 | ||
| BODY DEFENSES: RESISTANCE TO MICROBIAL DISEASE | 3 | ||
| COMPARISON OF INNATE AND ADAPTIVE IMMUNITY | 5 | ||
| ?Identification of Leukocytes Related to Immune Function | 7 | ||
| CHAPTER HIGHLIGHTS | 7 | ||
| BIBLIOGRAPHY | 9 | ||
| Chapter 2 - Antigens and Antibodies | 10 | ||
| ANTIGEN CHARACTERISTICS | 11 | ||
| CHEMICAL NATURE OF ANTIGENS | 13 | ||
| PHYSICAL NATURE OF ANTIGENS | 13 | ||
| GENERAL CHARACTERISTICS OF ANTIBODIES | 13 | ||
| IMMUNOGLOBULIN (IG) CLASSES | 14 | ||
| ANTIBODY STRUCTURE | 16 | ||
| IMMUNOGLOBULIN VARIANTS | 17 | ||
| ANTIBODY SYNTHESIS | 18 | ||
| FUNCTIONS OF ANTIBODIES | 20 | ||
| ANTIGEN-ANTIBODY INTERACTION: SPECIFICITY AND CROSS-REACTIVITY | 20 | ||
| MOLECULAR BASIS OF ANTIGEN-ANTIBODY REACTIONS | 22 | ||
| MONOCLONAL ANTIBODIES | 23 | ||
| ?ABO Blood Grouping (Forward Antigen Typing) | 26 | ||
| CHAPTER HIGHLIGHTS | 26 | ||
| BIBLIOGRAPHY | 29 | ||
| Chapter 3 - Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells | 30 | ||
| ORIGIN AND DEVELOPMENT OF BLOOD CELLS | 31 | ||
| GRANULOCYTIC CELLS | 31 | ||
| PROCESS OF PHAGOCYTOSIS | 32 | ||
| MONOCYTES-MACROPHAGES | 35 | ||
| ACUTE INFLAMMATION | 38 | ||
| SEPSIS | 39 | ||
| CELL SURFACE RECEPTORS | 39 | ||
| DISORDERS OF NEUTROPHILS | 40 | ||
| MONOCYTE-MACROPHAGE DISORDERS | 41 | ||
| DISEASE STATES INVOLVING LEUKOCYTE INTEGRINS | 42 | ||
| CHAPTER HIGHLIGHTS | 44 | ||
| BIBLIOGRAPHY | 47 | ||
| Chapter 4 - Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells | 48 | ||
| LYMPHOCYTES AND PLASMA CELLS | 49 | ||
| LYMPHOID AND NONLYMPHOID SURFACE MEMBRANE MARKERS | 49 | ||
| VIRGIN OR NAÏVE LYMPHOCYTES | 53 | ||
| DEVELOPMENT OF T LYMPHOCYTES | 53 | ||
| NATURAL KILLER AND K-TYPE LYMPHOCYTES | 62 | ||
| DEVELOPMENT AND DIFFERENTIATION OF B LYMPHOCYTES | 63 | ||
| B LYMPHOCYTE SUBSETS | 63 | ||
| PLASMA CELL BIOLOGY | 64 | ||
| ALTERATIONS IN LYMPHOCYTE SUBSETS | 64 | ||
| EVALUATION OF IMMUNODEFICIENCY SYNDROMES | 65 | ||
| IMMUNOLOGIC DISORDERS | 66 | ||
| CHAPTER HIGHLIGHTS | 73 | ||
| BIBLIOGRAPHY | 76 | ||
| chapter 5 - Soluble Mediators of the Immune System | 78 | ||
| THE COMPLEMENT SYSTEM | 79 | ||
| CLASSIC PATHWAY | 81 | ||
| ALTERNATIVE PATHWAY | 83 | ||
| MANNOSE-BINDING LECTIN PATHWAY | 83 | ||
| BIOLOGICAL FUNCTIONS OF COMPLEMENT PROTEINS | 83 | ||
| DIAGNOSTIC EVALUATION | 85 | ||
| OTHER SOLUBLE IMMUNE RESPONSE MEDIATORS | 86 | ||
| HEMATOPOIETIC STIMULATORS | 92 | ||
| ACUTE-PHASE PROTEINS | 93 | ||
| ?C-Reactive Protein Rapid Latex Agglutination Test | 96 | ||
| CHAPTER HIGHLIGHTS | 98 | ||
| BIBLIOGRAPHY | 101 | ||
| PART II - The Theory of Immunologicand Serologic Procedures | 103 | ||
| chapter 6 - Safety in the Immunology-Serology Laboratory | 103 | ||
| SAFETY STANDARDS AND AGENCIES | 104 | ||
| PREVENTION OF TRANSMISSION OF INFECTIOUS DISEASES | 105 | ||
| SAFE WORK PRACTICES FOR INFECTION CONTROL | 105 | ||
| PROTECTIVE TECHNIQUES FOR INFECTION CONTROL | 106 | ||
| HANDWASHING | 106 | ||
| SPECIMEN-PROCESSING PROTECTION | 108 | ||
| ADDITIONAL LABORATORY HAZARDS | 108 | ||
| DECONTAMINATION OF WORK SURFACES, EQUIPMENT, AND SPILLS | 109 | ||
| DISPOSAL OF INFECTIOUS LABORATORY WASTE | 109 | ||
| DISEASE PREVENTION | 110 | ||
| BASIC FIRST AID PROCEDURES | 112 | ||
| CHAPTER HIGHLIGHTS | 113 | ||
| BIBLIOGRAPHY | 114 | ||
| Chapter 7 - Quality Assurance and Quality Control | 115 | ||
| CLINICAL LABORATORY REGULATORY AND ACCREDITING ORGANIZATIONS | 116 | ||
| NONANALYTICAL FACTORS RELATED TO TESTING ACCURACY | 116 | ||
| ERRORS RELATED TO PHASE OF TESTING | 117 | ||
| QUALITY DESCRIPTORS | 117 | ||
| MONITORING QUALITY | 118 | ||
| REFERENCE RANGE STATISTICS | 119 | ||
| TESTING OUTCOMES | 119 | ||
| VALIDATING NEW PROCEDURES | 120 | ||
| CHAPTER HIGHLIGHTS | 122 | ||
| BIBLIOGRAPHY | 124 | ||
| Chapter 8 - Basic Serologic Laboratory Techniques | 125 | ||
| PROCEDURES MANUAL | 126 | ||
| BLOOD SPECIMEN PREPARATION | 126 | ||
| TYPES OF SPECIMENS TESTED | 126 | ||
| INACTIVATION OF COMPLEMENT | 126 | ||
| PIPETTES | 126 | ||
| PIPETTING TECHNIQUES | 127 | ||
| DILUTIONS | 129 | ||
| ANTIBODY TESTING | 132 | ||
| ANTIBODY TITER | 132 | ||
| CHAPTER HIGHLIGHTS | 133 | ||
| BIBLIOGRAPHY | 134 | ||
| Chapter 9 - Point-of-Care Testing | 135 | ||
| TESTING CATEGORIES | 135 | ||
| QUALITY CONTROL STANDARDS | 135 | ||
| NON–INSTRUMENT-BASED TESTING | 136 | ||
| CHAPTER HIGHLIGHTS | 138 | ||
| BIBLIOGRAPHY | 138 | ||
| Chapter 10 - Agglutination Methods | 139 | ||
| PRINCIPLES OF AGGLUTINATION | 139 | ||
| LATEX AGGLUTINATION | 140 | ||
| PREGNANCY TESTING | 140 | ||
| FLOCCULATION TESTS | 142 | ||
| DIRECT BACTERIAL AGGLUTINATION | 142 | ||
| HEMAGGLUTINATION | 142 | ||
| CHAPTER HIGHLIGHTS | 148 | ||
| BIBLIOGRAPHY | 150 | ||
| Chapter 11 - Electrophoresis Techniques | 151 | ||
| ELECTROPHORESIS | 151 | ||
| IMMUNOELECTROPHORESIS | 152 | ||
| IMMUNOFIXATION ELECTROPHORESIS | 156 | ||
| COMPARISON OF TECHNIQUES | 156 | ||
| CAPILLARY ELECTROPHORESIS | 156 | ||
| ?Immunofixation Electrophoresis Procedure | 158 | ||
| CHAPTER HIGHLIGHTS | 158 | ||
| BIBLIOGRAPHY | 159 | ||
| Chapter 12 - Labeling Techniques in Immunoassay | 160 | ||
| IMMUNOASSAY FORMATS | 160 | ||
| TYPES OF LABELS | 161 | ||
| ENZYME IMMUNOASSAY | 161 | ||
| CHEMILUMINESCENCE | 162 | ||
| IMMUNOFLUORESCENCE | 164 | ||
| EMERGING LABELING TECHNOLOGIES | 165 | ||
| ?Direct Fluorescent Antibody Test for Neisseria gonorrhoeae | 168 | ||
| CHAPTER HIGHLIGHTS | 168 | ||
| BIBLIOGRAPHY | 169 | ||
| Chapter 13 - Automated Procedures | 170 | ||
| CHARACTERISTICS OF AUTOMATED TESTING | 170 | ||
| NEPHELOMETRY | 171 | ||
| FLOW CELL CYTOMETRY | 172 | ||
| TRENDS IN IMMUNOASSAY AUTOMATION | 178 | ||
| CHAPTER HIGHLIGHTS | 181 | ||
| BIBLIOGRAPHY | 182 | ||
| Chapter 14 - Molecular Techniques | 183 | ||
| CHARACTERISTICS OF NUCLEIC ACIDS | 183 | ||
| AMPLICONS AND AMPLICON CONTROL MEASURES | 186 | ||
| AMPLIFICATION TECHNIQUES IN MOLECULAR BIOLOGY | 186 | ||
| ANALYSIS OF AMPLIFICATION PRODUCTS | 187 | ||
| NEXT GENERATION SEQUENCING TECHNOLOGY | 191 | ||
| FUTURE DIRECTIONS OF MOLECULAR DIAGNOSTIC TESTING | 192 | ||
| ?Molecular Testing Procedure: Group A Streptococcus Direct Test | 193 | ||
| CHAPTER HIGHLIGHTS | 193 | ||
| BIBLIOGRAPHY | 195 | ||
| PART III -\rImmunologic Manifestations of Infectious Diseases | 197 | ||
| Chapter 15 - The Immune Response in Infectious Diseases | 197 | ||
| CHARACTERISTICS OF INFECTIOUS DISEASES | 198 | ||
| DEVELOPMENT OF INFECTIOUS DISEASES | 198 | ||
| BACTERIAL DISEASES | 198 | ||
| PARASITIC DISEASES | 198 | ||
| FUNGAL DISEASES | 199 | ||
| VIRAL, RICKETTSIAL, AND MYCOPLASMAL DISEASES | 201 | ||
| LABORATORY DETECTION OF IMMUNOLOGIC RESPONSES | 203 | ||
| ?Latex-Cryptococcus Antigen Detection System | 205 | ||
| CHAPTER HIGHLIGHTS | 205 | ||
| BIBLIOGRAPHY | 207 | ||
| Chapter 16 - A Primer on Vaccines | 208 | ||
| WHAT IS A VACCINE? | 208 | ||
| CHARACTERISTICS OF A VACCINE | 208 | ||
| HOST RESPONSE TO VACCINATION | 209 | ||
| HISTORY OF VACCINES | 209 | ||
| APPLICATIONS OF VACCINES | 209 | ||
| VACCINE APPROVAL | 210 | ||
| CONCERNS ABOUT VACCINES | 214 | ||
| REPRESENTATIVE VACCINES | 214 | ||
| VACCINES IN BIODEFENSE | 219 | ||
| CHAPTER HIGHLIGHTS | 221 | ||
| BIBLIOGRAPHY | 222 | ||
| Chapter 17 - Streptococcal Infections | 223 | ||
| ETIOLOGY | 223 | ||
| EPIDEMIOLOGY | 225 | ||
| SIGNS AND SYMPTOMS | 225 | ||
| IMMUNOLOGIC MANIFESTATIONS | 226 | ||
| DIAGNOSTIC EVALUATION | 227 | ||
| STREPTOCOCCAL TOXIC SHOCK SYNDROME | 227 | ||
| GROUP B STREPTOCOCCAL DISEASE | 228 | ||
| CHAPTER HIGHLIGHTS | 229 | ||
| BIBLIOGRAPHY | 231 | ||
| Chapter 18 - Syphilis | 232 | ||
| ETIOLOGY | 232 | ||
| EPIDEMIOLOGY | 233 | ||
| SIGNS AND SYMPTOMS | 233 | ||
| IMMUNOLOGIC MANIFESTATIONS | 237 | ||
| DIAGNOSTIC EVALUATION | 237 | ||
| ?Classic VDRL Procedure: VDRL Qualitative Slide Test | 242 | ||
| ?Fluorescent Treponemal Antibody Absorption Test | 243 | ||
| CHAPTER HIGHLIGHTS | 243 | ||
| BIBLIOGRAPHY | 244 | ||
| Chapter 19 - Vector-Borne Diseases | 246 | ||
| LYME DISEASE | 248 | ||
| HUMAN EHRLICHIOSIS | 254 | ||
| ROCKY MOUNTAIN SPOTTED FEVER | 255 | ||
| BABESIOSIS | 256 | ||
| WEST NILE VIRUS | 257 | ||
| ?Rapid Borrelia burgdorferi Antibody Detection Assay | 260 | ||
| CHAPTER HIGHLIGHTS | 260 | ||
| BIBLIOGRAPHY | 263 | ||
| Chapter 20 - Toxoplasmosis | 264 | ||
| ETIOLOGY | 264 | ||
| EPIDEMIOLOGY | 264 | ||
| SIGNS AND SYMPTOMS | 266 | ||
| IMMUNOLOGIC MANIFESTATIONS | 267 | ||
| DIAGNOSTIC EVALUATION | 267 | ||
| CHAPTER HIGHLIGHTS | 269 | ||
| BIBLIOGRAPHY | 270 | ||
| Chapter 21 - Cytomegalovirus | 271 | ||
| ETIOLOGY | 271 | ||
| EPIDEMIOLOGY | 271 | ||
| SIGNS AND SYMPTOMS | 272 | ||
| IMMUNOLOGIC MANIFESTATIONS | 273 | ||
| LABORATORY EVALUATION | 274 | ||
| ?Passive Latex Agglutination for Detection of Antibodies to Cytomegalovirus | 275 | ||
| CHAPTER HIGHLIGHTS | 276 | ||
| BIBLIOGRAPHY | 278 | ||
| Chapter 22 - Infectious Mononucleosis | 279 | ||
| ETIOLOGY | 279 | ||
| EPIDEMIOLOGY | 279 | ||
| SIGNS AND SYMPTOMS | 280 | ||
| LABORATORY DIAGNOSTIC EVALUATION | 280 | ||
| IMMUNOLOGIC MANIFESTATIONS | 280 | ||
| CHAPTER HIGHLIGHTS | 285 | ||
| BIBLIOGRAPHY | 286 | ||
| Chapter 23 - Viral Hepatitis | 287 | ||
| GENERAL CHARACTERISTICS OF HEPATITIS | 288 | ||
| HEPATITIS A | 288 | ||
| HEPATITIS B | 292 | ||
| HEPATITIS D | 299 | ||
| HEPATITIS C | 300 | ||
| HEPATITIS E | 307 | ||
| HEPATITIS G | 308 | ||
| TRANFUSION-TRANSMITTED VIRUS | 309 | ||
| CHAPTER HIGHLIGHTS | 311 | ||
| BIBLIOGRAPHY | 313 | ||
| Chapter 24 - Rubella and Rubeola Infections | 315 | ||
| RUBELLA | 315 | ||
| RUBEOLA (MEASLES) | 319 | ||
| CHAPTER HIGHLIGHTS | 320 | ||
| BIBLIOGRAPHY | 321 | ||
| Chapter 25 - Acquired Immunodeficiency Syndrome | 322 | ||
| ETIOLOGY | 322 | ||
| EPIDEMIOLOGY | 325 | ||
| SIGNS AND SYMPTOMS | 330 | ||
| IMMUNOLOGIC MANIFESTATIONS | 332 | ||
| DIAGNOSTIC EVALUATION AND MONITORING | 333 | ||
| TESTING METHODS | 333 | ||
| PREVENTION | 337 | ||
| TREATMENT | 338 | ||
| CHAPTER HIGHLIGHTS | 343 | ||
| BIBLIOGRAPHY | 344 | ||
| PART IV -\rImmune Disorders | 347 | ||
| Chapter 26 - Hypersensitivity Reactions | 347 | ||
| WHAT IS HYPERSENSITIVITY? | 348 | ||
| WHAT IS AN ALLERGY? | 348 | ||
| TYPES OF ANTIGENS AND REACTIONS | 348 | ||
| TYPES OF HYPERSENSITIVITY REACTIONS | 348 | ||
| CHAPTER HIGHLIGHTS | 363 | ||
| BIBLIOGRAPHY | 364 | ||
| Chapter 27 - Immunoproliferative Disorders | 366 | ||
| GENERAL CHARACTERISTICS OF GAMMOPATHIES | 367 | ||
| MULTIPLE MYELOMA | 367 | ||
| WALDENSTRÖM’S PRIMARY MACROGLOBULINEMIA | 375 | ||
| OTHER MONOCLONAL DISORDERS | 377 | ||
| CHAPTER HIGHLIGHTS | 379 | ||
| BIBLIOGRAPHY | 381 | ||
| Chapter 28 - Autoimmune Disorders | 382 | ||
| WHAT IS AUTOIMMUNITY? | 382 | ||
| SPECTRUM OF AUTOIMMUNE DISORDERS | 383 | ||
| FACTORS INFLUENCING DEVELOPMENT OF AUTOIMMUNITY | 383 | ||
| IMMUNOPATHOGENIC MECHANISMS | 383 | ||
| SELF-RECOGNITION (TOLERANCE) | 385 | ||
| MAJOR AUTOANTIBODIES | 386 | ||
| ORGAN-SPECIFIC AND MIDSPECTRUM DISORDERS | 386 | ||
| CHAPTER HIGHLIGHTS | 403 | ||
| BIBLIOGRAPHY | 406 | ||
| Chapter 29 - Systemic Lupus Erythematosus | 407 | ||
| DIFFERENT FORMS OF LUPUS | 407 | ||
| ETIOLOGY | 409 | ||
| EPIDEMIOLOGY | 409 | ||
| SIGNS AND SYMPTOMS | 410 | ||
| IMMUNOLOGIC MANIFESTATIONS | 412 | ||
| DIAGNOSTIC EVALUATION | 414 | ||
| TREATMENT | 418 | ||
| ?Autoimmune Enzyme Immunoassay ANA Screening Test | 421 | ||
| CHAPTER HIGHLIGHTS | 422 | ||
| BIBLIOGRAPHY | 423 | ||
| Chapter 30 - Rheumatoid Arthritis | 424 | ||
| ETIOLOGY | 424 | ||
| EPIDEMIOLOGY | 425 | ||
| SIGNS AND SYMPTOMS | 425 | ||
| ANATOMY AND PHYSIOLOGY OF JOINTS | 426 | ||
| IMMUNOLOGIC MANIFESTATIONS | 426 | ||
| DIAGNOSTIC EVALUATION | 428 | ||
| JUVENILE IDIOPATHIC ARTHRITIS | 429 | ||
| TREATMENT | 430 | ||
| DIAGNOSTIC PROCEDURES | 432 | ||
| CHAPTER HIGHLIGHTS | 434 | ||
| BIBLIOGRAPHY | 435 | ||
| Chapter 31 - Solid Organ Transplantation | 436 | ||
| HISTOCOMPATIBILITY ANTIGENS | 437 | ||
| FACTS ABOUT SOLID ORGAN TRANSPLANTATION | 442 | ||
| TRANSPLANTATION TERMINOLOGY | 443 | ||
| TYPES OF TRANSPLANTS | 443 | ||
| GRAFT-VERSUS-HOST DISEASE | 446 | ||
| GRAFT REJECTION | 449 | ||
| MECHANISMS OF REJECTION | 451 | ||
| BIOMARKERS FOR REJECTION | 456 | ||
| FOXP3 MRNA | 456 | ||
| ?Longitudinal Assessment of Posttransplant Immune Status | 457 | ||
| CHAPTER HIGHLIGHTS | 458 | ||
| BIBLIOGRAPHY | 459 | ||
| Chapter 32 - Bone Marrow Transplantation | 461 | ||
| CANCERS TREATED WITH PROGENITOR CELL TRANSPLANTS | 461 | ||
| WHAT ARE PROGENITOR BLOOD CELLS? | 462 | ||
| TYPES OF TRANSPLANTS | 463 | ||
| TRADITIONAL TREATMENT OPTIONS | 463 | ||
| EVALUATION OF CANDIDATES FOR PERIPHERAL BLOOD STEM CELL AND BONE MARROW TRANSPLANTATION | 464 | ||
| OBTAINING CELLS FOR TRANSPLANTATION | 464 | ||
| TRANSPLANTATION | 467 | ||
| TRANSPLANTS FROM UNRELATED DONORS | 469 | ||
| CURRENT DIRECTIONS | 469 | ||
| CHAPTER HIGHLIGHTS | 471 | ||
| BIBLIOGRAPHY | 473 | ||
| Chapter 33 - Tumor Immunology | 474 | ||
| CANCER STEM CELLS | 475 | ||
| TYPES OF TUMORS | 475 | ||
| EPIDEMIOLOGY | 476 | ||
| CAUSATIVE FACTORS IN HUMAN CANCER | 477 | ||
| STAGES OF CARCINOGENESIS | 478 | ||
| CANCER-PREDISPOSING GENES | 478 | ||
| PROTO-ONCOGENES | 479 | ||
| ROLE OF ONCOGENES | 479 | ||
| BODY DEFENSES AGAINST CANCER | 480 | ||
| TUMOR MARKERS | 481 | ||
| DNA MICROARRAY TECHNOLOGY | 486 | ||
| WHAT’S NEW IN CANCER DIAGNOSTIC TESTING? | 487 | ||
| MODALITIES FOR TREATING CANCER | 487 | ||
| CHAPTER HIGHLIGHTS | 491 | ||
| BIBLIOGRAPHY | 493 | ||
| APPENDIX A - ANSWERS TO CASE STUDY MULTIPLE CHOICE QUESTIONS | 495 | ||
| CHAPTER 1: AN OVERVIEW OF IMMUNOLOGY | 495 | ||
| CHAPTER 2: ANTIGENS AND ANTIBODIES | 495 | ||
| CHAPTER 3: CELLS AND CELLULAR ACTIVITIES OF THE IMMUNE SYSTEM: GRANULOCYTES AND MONONUCLEAR CELLS | 495 | ||
| CHAPTER 4: CELLS AND CELLULAR ACTIVITIES OF THE IMMUNE SYSTEM: LYMPHOCYTES AND PLASMA CELLS | 495 | ||
| CHAPTER 5: SOLUBLE MEDIATORS OF THE IMMUNE SYSTEM | 495 | ||
| CHAPTER 6: SAFETY IN THE IMMUNOLOGY-SEROLOGY LABORATORY | 495 | ||
| CHAPTER 7: QUALITY ASSURANCE AND QUALITY CONTROL | 495 | ||
| CHAPTER 8: BASIC SEROLOGIC LABORATORY TECHNIQUES | 495 | ||
| CHAPTER 9: POINT-OF-CARE TESTING | 495 | ||
| CHAPTER 10: AGGLUTINATION METHODS | 495 | ||
| CHAPTER 11: ELECTROPHORESIS TECHNIQUES | 495 | ||
| CHAPTER 12: LABELING TECHNIQUES IN IMMUNOASSAY | 495 | ||
| CHAPTER 13: AUTOMATED PROCEDURES | 495 | ||
| CHAPTER 14: MOLECULAR TECHNIQUES | 495 | ||
| CHAPTER 15: THE IMMUNE RESPONSE IN INFECTIOUS DISEASES | 495 | ||
| CHAPTER 16: A PRIMER ON VACCINES | 495 | ||
| CHAPTER 17: STREPTOCOCCAL INFECTIONS | 495 | ||
| CHAPTER 18: SYPHILIS | 495 | ||
| CHAPTER 19: VECTOR-BORNE DISEASES | 496 | ||
| CHAPTER 20: TOXOPLASMOSIS | 496 | ||
| CHAPTER 21: CYTOMEGALOVIRUS | 496 | ||
| CHAPTER 22: INFECTIOUS MONONUCLEOSIS | 496 | ||
| CHAPTER 23: VIRAL HEPATITIS | 496 | ||
| CHAPTER 24: RUBELLA INFECTION | 496 | ||
| CHAPTER 25: ACQUIRED IMMUNODEFICIENCY SYNDROME | 496 | ||
| CHAPTER 26: HYPERSENSITIVITY REACTIONS | 496 | ||
| CHAPTER 27: IMMUNOPROLIFERATIVE DISORDERS | 496 | ||
| CHAPTER 28: AUTOIMMUNE DISORDERS | 496 | ||
| CHAPTER 29: SYSTEMIC LUPUS ERYTHEMATOSUS | 496 | ||
| CHAPTER 30: RHEUMATOID ARTHRITIS | 496 | ||
| CHAPTER 31: SOLID ORGAN TRANSPLANTATION | 497 | ||
| CHAPTER 32: BONE MARROW TRANSPLANTATION | 497 | ||
| CHAPTER 33: TUMOR IMMUNOLOGY | 497 | ||
| Appendix B - Answers to Review Questions | 498 | ||
| CHAPTER 1: AN OVERVIEW OF IMMUNOLOGY | 498 | ||
| CHAPTER 2: ANTIGENS AND ANTIBODIES | 498 | ||
| CHAPTER 3: CELLS AND CELLULAR ACTIVITIES OF THE IMMUNE SYSTEM: GRANULOCYTES AND MONONUCLEAR CELLS | 498 | ||
| CHAPTER 4: CELLS AND CELLULAR ACTIVITIES OF THE IMMUNE SYSTEM: LYMPHOCYTES AND PLASMA CELLS | 498 | ||
| CHAPTER 5: SOLUBLE MEDIATORS OF THE IMMUNE SYSTEM | 498 | ||
| CHAPTER 6: SAFETY IN THE IMMUNOLOGY-SEROLOGY LABORATORY | 499 | ||
| CHAPTER 17: STREPTOCOCCAL INFECTIONS | 500 | ||
| CHAPTER 28: AUTOIMMUNE DISORDERS | 501 | ||
| APPENDIX C - REPRESENTATIVE DIAGNOSTIC ASSAYS IN MEDICAL LABORATORY IMMUNOLOGY | 502 | ||
| BIBLIOGRAPHY | 509 | ||
| Glossary | 511 | ||
| Index | 537 | ||
| Turgeon Color Plates legends | 569 |