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Rau's Respiratory Care Pharmacology - E-Book

Rau's Respiratory Care Pharmacology - E-Book

Douglas S. Gardenhire


Additional Information

Book Details


With an approach to learning as progressive as its content, Rau’s Respiratory Care Pharmacology, 8th Edition simplifies the process of learning challenging pharmacology material like never before. Rau’s effective approach uses broken-down terminology, relatable explanations, reader-friendly writing, and additional workbook guidance to help you easily master the text’s cutting-edge content – which includes the latest terms, pronunciations, in-depth sleep pharmacology, reality-based case studies, and SOAP assessment opportunities. Plus, the online interactive flashcards and audio pronunciation glossary offer additional learning formats tailored to your digital preferences.

  • Improved readability makes it easier for you to grasp difficult material.
  • Expanded! Key terms and definitions include over 275 terms with pronunciations. 
  • Companion workbook offers a wide range of activities that help you apply knowledge gained from the core text and break down more difficult concepts beyond NBRC style multiple-choice questions.
  • Clinical Scenarios with follow-up SOAP assessment provide you with a reality-based patient case study and an opportunity to indicate standardized treatment.
  • Inside back cover offers a quick-reference list of the most commonly used abbreviations in pharmacology with full application.
  • Full-color format draws out special features and creates a more reader-friendly text.
  • Glossary aids your comprehension of pharmacology terminology.
  • Learning objectives parallel the recall, analysis, and application levels tested on the NBRC exam to prepare you for credentialing.
  • Key terms with definitions enable you to quickly master essential terminology.
  • Key Points boxes guide you in preparing for tests by identifying the most important concepts in each chapter.
  • Self-assessment questions allow you to test yourself on key information within the chapter. 
  • Student Resources on Evolve, including an audio glossary and electronic flashcards, provide opportunities to hone your understanding of respiratory pharmacology concepts.

Table of Contents

Section Title Page Action Price
UNIT ONE Basic Concepts and Principles in Pharmacology 1
Chapter 1 Introduction to Respiratory Care Pharmacology 2
Pharmacology and the Study of Drugs 3
Naming Drugs 4
Sources of Drug Information 5
Sources of Drugs 5
Process for Drug Approval in the United States 5
The Prescription 7
Respiratory Care Pharmacology: An Overview 9
References 10
Chapter 2 Principles of Drug Action 11
Drug Administration Phase 12
Pharmacokinetic Phase 14
Pharmacodynamic Phase 23
Pharmacogenetics 29
References 30
Chapter 3 Administration of Aerosolized Agents 31
Physical Principles of Inhaled Aerosol Drugs 32
Aerosol Generators for Drug Delivery 37
Selecting an Aerosol Device 56
Clinical Application of Aerosol Delivery Devices 56
References 62
Chapter 4 Calculating Drug Doses 65
Systems of Measure 65
Calculating Doses from Prepared-Strength Solutions 67
Calculating Doses from Percentage-Strength Solutions 69
References 75
Chapter 5 Central and Peripheral Nervous Systems 76
Nervous System 77
Autonomic Branches 77
Parasympathetic Branch 80
Cholinergic Agents 82
Anticholinergic Agents 83
Sympathetic Branch 84
Sympathomimetic (Adrenergic) and Sympatholytic (Antiadrenergic) Agents 88
Neural Control of Lung Function 88
References 94
UNIT TWO Drugs Used to Treat the Respiratory System 95
Chapter 6 Adrenergic (Sympathomimetic) Bronchodilators 96
Clinical Indications for Adrenergic Bronchodilators 97
Specific Adrenergic Agents and Formulations 97
Mode of Action 107
Routes of Administration 109
Adverse Side Effects 111
Compatibility of Other Agents with Bronchodilators 115
β-Agonist Controversy 115
Respiratory Care Assessment of β-Agonist Therapy 116
References 117
Chapter 7 Anticholinergic (Parasympatholytic) Bronchodilators 119
Clinical Indications for Use 120
Specific Anticholinergic (Parasympatholytic) Agents 120
Clinical Pharmacology 122
Mode of Action 125
Adverse Effects 127
Clinical Application 128
Respiratory Care Assessment of Anticholinergic Bronchodilator Therapy 131
References 133
Chapter 8 Xanthines 135
Clinical Indications for the Use of Xanthines 135
Specific Xanthine Agents 136
General Pharmacologic Properties 136
Titrating Theophylline Doses 139
Respiratory Care Assessment of Xanthines 142
References 143
Chapter 9 Mucus-Controlling Drug Therapy 145
Drug Control of Mucus: A Perspective 146
Physiology of the Mucociliary System 147
Nature of Mucus Secretion 151
Physical Properties of Mucus 154
Mucoactive Agents 155
Mucolytics and Expectorants 156
Mucokinetic Agents 159
Mucoregulatory Medications 160
Other Mucoactive Agents 160
Gene Therapy 161
Using Mucoactive Therapy with Physiotherapy and Airway Clearance Devices 161
Future Mucus-Controlling Agents 163
Respiratory Care Assessment of Mucoactive Drug Therapy 164
References 166
Chapter 10 Surfactant Agents 171
Physical Principles 172
Clinical Indications for Exogenous Surfactants 172
Identification of Surfactant Preparations 173
Specific Exogenous Surfactant Preparations 176
Mode of Action 178
Clinical Outcome 178
Hazards and Complications of Surfactant Therapy 178
Future Directions in Surfactant Therapy 179
Respiratory Care Assessment of Surfactant Therapy 179
References 180
Chapter 11 Corticosteroids in Respiratory Care 181
Clinical Indications for Use of Inhaled Corticosteroids 182
Identification of Aerosolized Corticosteroids 182
Physiology of Corticosteroids 182
Nature of Inflammatory Response 185
Aerosolized Corticosteroids 187
Pharmacology of Corticosteroids 190
Hazards and Side Effects of Steroids 192
Clinical Application of Aerosol Steroids 195
Respiratory Care Assessment of Inhaled Corticosteroid Therapy 196
References 197
Chapter 12 Nonsteroidal Antiasthma Agents 200
Clinical Indications for Nonsteroidal Antiasthma Agents 201
Identification of Nonsteroidal Antiasthma Agents 201
Mechanisms of Inflammation in Asthma 201
Cromolyn (Mast Cell–Stabilizing) Agents 204
Antileukotriene Agents 206
Respiratory Care Assessment of Nonsteroidal Antiasthma Agents 214
References 215
Chapter 13 Aerosolized Antiinfective Agents 217
Clinical Indications for Aerosolized Antiinfective Agents 218
Identification of Aerosolized Antiinfective Agents 218
Respiratory Care Assessment of Aerosolized Antiinfective Agents 231
References 234
Chapter 14 Antimicrobial Agents 236
Principles of Antimicrobial Therapy 237
Antibiotics 241
Antimycobacterials 253
Antifungals 255
Antiviral Agents 258
Respiratory Care and Assessment of Antibiotic Therapy 261
References 262
Chapter 15 Cold and Cough Agents 263
Sympathomimetic (Adrenergic) Decongestants 264
Antihistamine Agents 265
Expectorants 267
Cough Suppressants (Antitussives) 268
Cold Compounds 269
Respiratory Care Assessment of Cold and Cough Agents 270
References 271
Chapter 16 Selected Agents of Pulmonary Value 272
Respiratory Care Assessment of Therapy of α₁-Proteinase Inhibitor (Human) 274
Smoking Cessation Drug Therapy 275
Respiratory Care Assessment of Smoking Cessation Drug Therapy 278
Nitric Oxide 278
Respiratory Care Assessment of Nitric Oxide 281
Synthetic Analogues of Prostacyclin (PGI₂) 281
Respiratory Care Assessment of Synthetic Analogues of Prostacyclin (PGI₂) 282
References 283
Chapter 17 Neonatal and Pediatric Aerosolized Drug Therapy 285
Off-Label Use of Drugs in Neonatal and Pediatric Patients 286
Factors Affecting Neonatal and Pediatric Aerosol Drug Delivery 287
Nebulized Drug Distribution 289
Clinical Response to Aerosolized Drugs in Neonatal and Pediatric Patients 291
Selection of Delivery Devices 291
Compliance and Cooperation during Aerosol Therapy 293
Aerosol Administration in Intubated Neonatal and Pediatric Patients 294
Summary 294
References 295
UNIT THREE Critical Care, Cardiovascular, and Polysomnography Agents 298
Chapter 18 Skeletal Muscle Relaxants (Neuromuscular Blocking Agents) 299
Uses of Neuromuscular Blocking Agents 300
Physiology of the Neuromuscular Junction 300
Nondepolarizing Agents 301
Depolarizing Agents 305
Neuromuscular Blocking Agents and Mechanical Ventilation 306
Monitoring of Neuromuscular Blockade 309
Future of Neuromuscular Blocking Agents and Reversal 311
References 312
Chapter 19 Diuretic Agents 313
Renal Structure and Function 314
Diuretic Groups 315
Diuretic Combinations 319
Drug Interactions 319
Adverse Effects 320
Special Situations 321
References 323
Chapter 20 Drugs Affecting the Central Nervous System 325
Neurotransmitters 327
Psychiatric Medications 328
Ethyl Alcohol 332
Pain Treatment 332
Chronic Pain Syndromes 337
Anesthesia 337
Central Nervous System and Respiratory Stimulants 340
References 342
Chapter 21 Vasopressors, Inotropes, and Antiarrhythmic Agents 343
Overview of Cardiovascular System 344
Agents Used in the Management of Shock 348
Electrophysiology of Myocardium 350
Pharmacology of Antiarrhythmics 351
Management and Pharmacotherapy of Advanced Cardiac Life Support 362
Alternative Routes of Medication Administration 365
References 366
Chapter 22 Drugs Affecting Circulation: Antihypertensives, Antianginals, Antithrombotics 367
Hypertension 368
Hypertension Pharmacotherapy 370
Angina 381
Antithrombotic Agents 384
References 397
Chapter 23 Sleep and Sleep Pharmacology 399
History of Treatment of Sleep Disorders 400
Progression of Sleep 401
Neurophysiologic Mechanisms 402
Sleep Disorders: Causes and Treatments 410
References 415
Appendix A Units and Systems of Measurement 417
Appendix B Acceptable Mixtures of Most Commonly Prescribed Respiratory Care Drugs 421
Glossary of Selected Terms 422
Index 444