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Before We Are Born E-Book

Before We Are Born E-Book

Keith L. Moore | T. V. N. Persaud | Mark G. Torchia

(2015)

Additional Information

Book Details

Abstract

As the study of embryology continues to be integrated with a range of disciplines, Before We Are Born remains the ideal solution for students who need to quickly learn the basics. Fully updated by the world’s foremost embryologists, this medical reference book provides concise guidance on human embryology at every stage of development, utilizing rich illustrations and photographs designed to further explain content.

  • Understand all of the latest advances in embryology, including normal and abnormal embryogenesis, causes of birth defects, and the role of genes in human development.
  • See how discoveries in molecular biology have affected clinical practice, including the development of sophisticated new techniques such as recumbent DNA technology and stem cell manipulation.
  • Prepare for the USMLE Step 1 with clinical case presentations, highlighted in special boxes, which demonstrate how embryology concepts relate to clinical practice.
  • Quickly review just the embryology information you need to know, masterfully distilled from the popular book The Developing Human, written by the same author team.
  • Understand the complex concepts inherent in embryology with help from streamlined content, didactic illustrations, and clinical photos.
  • Test your knowledge with brand-new review questions at the end of each chapter.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Half title page i
Award page ii
Before We Are Born 9E iii
Copyright Page iv
Dedication v
Contributors vii
Preface xi
Acknowledgments xiii
Table Of Contents xv
1 Introduction to Human Development 1
Importance of and Advances in Embryology 1
Descriptive Terms 2
Clinically Oriented Questions 5
2 Human Reproduction 7
Reproductive Organs 7
Female Reproductive Organs 7
Vagina 7
Uterus 7
Uterine Tubes 10
Ovaries 10
Female External Sex Organs 10
Male Reproductive Organs 10
Gametogenesis 10
Meiosis 10
Spermatogenesis 11
Oogenesis 14
Comparison of Male and Female Gametes 14
Female Reproductive Cycles 14
Ovarian Cycle 14
Follicular Development 14
Ovulation 17
Corpus Luteum 18
Menstrual Cycle 18
Phases of Menstrual Cycle 18
Menstrual Phase 18
Proliferative Phase 18
Luteal Phase 18
Transportation of Gametes 19
Oocyte Transport 19
Sperm Transport 19
Maturation of Sperms 20
Viability of Oocytes and Sperms 20
Clinically Oriented Questions 20
3 First Week of Human Development 21
Fertilization 21
Phases of Fertilization 21
Results of Fertilization 23
Cleavage of Zygote 23
Formation of Blastocyst 23
Clinically Oriented Questions 27
4 Second Week of Human Development 29
Formation of Amniotic Cavity, Embryonic Disc, and Umbilical Vesicle 30
Development of Chorionic Sac 32
Implantation Sites of Blastocysts 33
Clinically Oriented Questions 34
5 Third Week of Human Development 35
Gastrulation: Formation of Germ Layers 35
Primitive Streak 36
Notochordal Process and Notochord 36
Allantois 36
Neurulation: Formation of the Neural Tube 38
Neural Plate and Neural Tube 38
Neural Crest Formation 39
Development of Somites 39
Development of Intraembryonic Coelom 40
Early Development of Cardiovascular System 40
Vasculogenesis and Angiogenesis 43
Development of Chorionic Villi 45
Clinically Oriented Questions 47
6 Fourth to Eighth Weeks of Human Development 49
Folding of Embryo 49
Head and Tail Folds 51
Lateral Folds 51
Germ Layer Derivatives 51
Control of Embryonic Development 51
Estimation of Embryonic Age 54
Highlights of the Fourth to Eighth Weeks 54
Fourth Week 55
Fifth Week 56
Sixth Week 58
Seventh Week 58
Eighth Week 58
Clinically Oriented Questions 61
7 Fetal Period: 63
Highlights of Fetal Period 64
Nine to Twelve Weeks 64
Thirteen to Sixteen Weeks 65
Seventeen to Twenty Weeks 65
Twenty-One to Twenty-Five Weeks 65
Twenty-Six to Twenty-Nine Weeks 66
Thirty to Thirty-Eight Weeks 67
Expected Date of Delivery 67
Factors Influencing Fetal Growth 67
Procedures for Assessing Fetal Status 68
Ultrasonography 68
Diagnostic Amniocentesis 68
Chorionic Villus Sampling 69
Cell Cultures 69
Percutaneous Umbilical Cord Blood Sampling 69
Magnetic Resonance Imaging 69
Fetal Monitoring 70
Alpha-Fetoprotein Assay 70
Noninvasive Prenatal Diagnosis 70
Neonatal Period 70
Clinically Oriented Questions 70
8 Placenta and Fetal Membranes 71
Placenta 71
Decidua 72
Development of Placenta 72
Fetomaternal Junction 72
Intervillous Space 72
Amniochorionic Membrane 74
Placental Circulation 74
Fetoplacental Circulation 74
Maternal-Placental Circulation 75
Placental Membrane 76
Functions of Placenta 77
Placental Metabolism 77
Placental Transport 77
Transfer of Gases. 77
Nutritional Substances. 78
Hormones. 78
Electrolytes. 78
Drugs and Drug Metabolites. 78
Infectious Agents. 79
Placental Protection by Maternal Antibodies 79
Placental Excretion of Waste Products 79
Placental Endocrine Synthesis and Secretion 79
Uterine Growth During Pregnancy 79
Parturition 79
Stages of Labor 79
Placenta and Fetal Membranes after Birth 80
Variations in Placental Shape 81
Maternal Surface of Placenta 81
Fetal Surface of Placenta 82
Umbilical Cord 82
Amnion and Amniotic Fluid 82
Significance of Amniotic Fluid 84
Umbilical Vesicle 84
Significance of Umbilical Vesicle 84
Allantois 84
Multiple Pregnancies 85
Twins and Fetal Membranes 85
Dizygotic Twins 85
Monozygotic Twins 85
Other Types of Multiple Births 88
Clinically Oriented Questions 89
9 Body Cavities, Mesenteries, and Diaphragm 91
Embryonic Body Cavity 91
Mesenteries 92
Division of Embryonic Body Cavity 92
Pleuropericardial Membranes 92
Pleuroperitoneal Membranes 93
Development of Diaphragm 95
Septum Transversum 95
Pleuroperitoneal Membranes 95
Dorsal Mesentery of Esophagus 95
Muscular Ingrowth from Lateral Body Walls 96
Positional Changes and Innervation of the Diaphragm 96
Clinically Oriented Questions 99
10 Pharyngeal Apparatus, Face, and Neck 101
Pharyngeal Arches 101
Pharyngeal Arch Components 102
Derivatives of Pharyngeal Arch Arteries 104
Derivatives of Pharyngeal Arch Cartilages 104
Derivatives of Pharyngeal Arch Muscles 104
Derivatives of Pharyngeal Arch Nerves 104
Pharyngeal Pouches 106
Derivatives of Pharyngeal Pouches 106
Pharyngeal Grooves 108
Pharyngeal Membranes 110
Development of Thyroid Gland 111
Development of Tongue 111
Lingual Papillae and Taste Buds 114
Nerve Supply of Tongue 114
Development of Salivary Glands 115
Development of Face 115
Development of Nasal Cavities 119
Paranasal Sinuses 120
Development of Palate 121
Primary Palate 121
Secondary Palate 121
Clinically Oriented Questions 126
11 Respiratory System 127
Development of Larynx 129
Development of Trachea 129
Development of Bronchi and Lungs 130
Maturation of Lungs 133
Pseudoglandular Period (5–17 Weeks) 133
Canalicular Period (16–25 Weeks) 133
Terminal Saccular Period (24 Weeks to Late Fetal Period) 134
Alveolar Period (Late Fetal Period to 8 Years) 134
Clinically Oriented Questions 135
12 Alimentary System 137
Foregut 137
Development of Esophagus 138
Development of Stomach 138
Rotation of Stomach 138
Mesenteries of Stomach 141
Omental Bursa 141
Development of Duodenum 141
Development of Liver and Biliary Apparatus 141
Ventral Mesentery 143
Development of Pancreas 143
Development of Spleen 143
Midgut 144
Rotation of Midgut Loop 145
Retraction of Intestinal Loops 145
Fixation of Intestines 145
Cecum and Appendix 145
Hindgut 153
Cloaca 153
Partitioning of Cloaca 153
Anal Canal 155
Clinically Oriented Questions 160
13 Urogenital System 161
Development of Urinary System 161
Development of Kidneys and Ureters 161
Pronephroi 162
Mesonephroi 162
Metanephroi 162
Positional Changes of Kidneys 165
Changes in Blood Supply of Kidneys 166
Development of Urinary Bladder 170
Development of Urethra 172
Development of Suprarenal Glands 172
Development of Genital System 174
Development of Gonads 174
Indifferent Gonads 174
Primordial Germ Cells 175
Sex Determination 175
Development of Testes 175
Development of Ovaries 176
Development of Genital Ducts 179
Development of Male Genital Ducts and Glands 179
Seminal Glands. 179
Prostate. 179
Bulbourethral Glands. 179
Development of Female Genital Ducts and Glands 179
Development of Vagina. 180
Female Auxiliary Genital Glands. 180
Development of External Genitalia 180
Development of Male External Genitalia 181
Development of Female External Genitalia 181
Development of Inguinal Canals 184
Relocation of Testes and Ovaries 187
Descent of Testes 187
Descent of Ovaries 187
Clinically Oriented Questions 188
14 Cardiovascular System 189
Early Development of Heart and Blood Vessels 190
Development of Veins Associated with Embryonic Heart 190
Pharyngeal Arch Arteries and Other Branches of the Dorsal Aorta 193
Intersegmental Arteries 193
Fate of Vitelline and Umbilical Arteries 193
Later Development of Heart 193
Circulation through Primordial Heart 197
Partitioning of Primordial Heart 197
Partitioning of Primordial Atrium 199
Changes in Sinus Venosus 199
Primordial Pulmonary Vein and Formation of Left Atrium 199
Partitioning of Primordial Ventricle 199
Partitioning of Bulbus Cordis and Truncus Arteriosus 201
Development of Cardiac Valves 203
Conducting System of Heart 203
Birth Defects of Heart and Great Vessels 204
Derivatives of Pharyngeal Arch Arteries 213
Derivatives of First Pair of Pharyngeal Arch Arteries 214
Derivatives of Second Pair of Pharyngeal Arch Arteries 214
Derivatives of Third Pair of Pharyngeal Arch Arteries 214
Derivatives of Fourth Pair of Pharyngeal Arch Arteries 214
Fate of Fifth Pair of Pharyngeal Arch Arteries 214
Derivatives of Sixth Pair of Pharyngeal Arch Arteries 214
Pharyngeal Arch Arterial Birth Defects 216
Fetal and Neonatal Circulation 216
Fetal Circulation 219
Transitional Neonatal Circulation 221
Derivatives of Fetal Vessels and Structures 221
Umbilical Vein and Round Ligament of Liver 221
Ductus Venosus and Ligamentum Venosum 221
Umbilical Arteries and Abdominal Ligaments 221
Oval Foramen and Oval Fossa 221
Ductus Arteriosus and Ligamentum Arteriosum 221
Development of the Lymphatic System 222
Development of Lymph Nodes 222
Development of Spleen and Tonsils 223
Clinically Oriented Questions 223
15 Musculoskeletal System 225
Skeletal System 225
Development of Cartilage and Bone 227
Histogenesis of Cartilage 227
Histogenesis of Bone 227
Intramembranous Ossification 227
Endochondral Ossification 227
Development of Joints 229
Fibrous Joints 229
Cartilaginous Joints 229
Synovial Joints 229
Development of Axial Skeleton 229
Development of Vertebral Column 230
Cartilaginous Stage of Vertebral Development 231
Bony Stage of Vertebral Development 231
Development of Ribs 232
Development of Sternum 232
Development of Cranium 232
Cartilaginous Neurocranium 232
Membranous Neurocranium 232
Cartilaginous Viscerocranium 233
Membranous Viscerocranium 233
Newborn Cranium 234
Postnatal Growth of Cranium 234
Development of Appendicular Skeleton 236
Muscular System 238
Development of Skeletal Muscle 239
Myotomes 240
Derivatives of Epaxial Divisions of Myotomes 240
Derivatives of Hypaxial Divisions of Myotomes 240
Pharyngeal Arch Muscles 240
Ocular Muscles 240
Tongue Muscles 240
Limb Muscles 241
Development of Smooth Muscle 241
Development of Cardiac Muscle 241
Development of Limbs 241
Early Stages of Limb Development 241
Final Stages of Limb Development 243
Cutaneous Innervation of Limbs 244
Blood Supply of Limbs 244
Clinically Oriented Questions 249
16 Nervous System 251
Development of Nervous System 251
Development of Spinal Cord 254
Development of Spinal Ganglia 256
Development of Spinal Meninges 257
Positional Changes of Spinal Cord 257
Myelination of Nerve Fibers 257
Birth Defects of Spinal Cord 257
Development of Brain 259
Brain Flexures 259
Hindbrain 259
Myelencephalon 260
Metencephalon 261
Choroid Plexuses and Cerebrospinal Fluid 263
Midbrain 264
Forebrain 264
Diencephalon 265
Telencephalon 267
Cerebral Commissures 267
Congenital Anomalies of Brain 268
Development of Peripheral Nervous System 272
Spinal Nerves 273
Cranial Nerves 273
Somatic Efferent Cranial Nerves 273
Nerves of Pharyngeal Arches 273
Special Sensory Nerves 274
Development of Autonomic Nervous System 275
Sympathetic Nervous System 275
Parasympathetic Nervous System 275
Clinically Oriented Questions 275
17 Development of Eyes and Ears 277
Development of Eyes and Related Structures 277
Development of Retina 279
Development of Choroid and Sclera 282
Development of Ciliary Body 282
Development of Iris 283
Development of Lens 283
Development of Aqueous Chambers 283
Development of Cornea 284
Development of Eyelids 284
Development of Lacrimal Glands 284
Development of Ears 284
Development of Internal Ears 284
Development of Middle Ears 285
Development of External Ears 286
Clinically Oriented Questions 289
18 Integumentary System 291
Development of Skin and Appendages 291
Epidermis 291
Dermis 292
Development of Glands 293
Sebaceous Glands 293
Sweat Glands 294
Development of Hairs 294
Development of Nails 294
Development of Mammary Glands 295
Development of Teeth 296
Bud Stage of Tooth Development 296
Cap Stage of Tooth Development 297
Bell Stage of Tooth Development 297
Tooth Eruption 299
Clinically Oriented Questions 301
19 Human Birth Defects 303
Teratology: Study of Abnormal Development 303
Birth Defects Caused by Genetic Factors* 304
Numerical Chromosomal Abnormalities 304
Trisomy 306
Structural Chromosomal Abnormalities 308
Translocation 309
Deletion 309
Birth Defects Caused by Mutant Genes 310
Birth Defects Caused by Environmental Factors 311
Principles of Teratogenesis 311
Critical Periods of Human Development 312
Human Teratogens 314
Cigarette Smoking 314
Alcohol 314
Androgens and Progestogens 314
Antibiotics 315
Anticoagulants 315
Anticonvulsants 315
Antineoplastic Agents 315
Angiotensin-Converting Enzyme Inhibitors 315
Retinoic Acid (Vitamin A) 315
Salicylates 315
Acetaminophen 316
Thyroid Drugs 316
Tranquilizers 316
Psychotropic Drugs 316
Illicit Drugs 316
Environmental Chemicals as Teratogens 317
Organic Mercury 317
Lead 317
Polychlorinated Biphenyls 317
Infectious Agents as Teratogens 317
Rubella (German Measles) 317
Cytomegalovirus 317
Herpes Simplex Virus 317
Varicella (Chickenpox) 317
Human Immunodeficiency Virus 318
Toxoplasmosis 318
Congenital Syphilis 318
Radiation as a Teratogen 318
Maternal Factors as Teratogens 318
Mechanical Factors as Teratogens 319
Birth Defects Caused by Multifactorial Inheritance 319
Clinically Oriented Questions 319
20 The Cellular and Molecular Basis of Development 321
Intercellular Communication 322
Gap Junctions 322
Cell Adhesion Molecules 322
Morphogens 323
Retinoic Acid 323
Transforming Growth Factor-β/ Bone Morphogenetic Protein 323
Sonic Hedgehog 323
Wnt/β-Catenin Pathway 325
Receptor Tyrosine Kinases 325
Common Features 325
Regulation of Angiogenesis by Receptor Tyrosine Kinases 326
Notch-Delta Pathway 326
Transcription Factors 326
Hox/Homeobox Proteins 327
Pax Genes 327
Basic Helix-Loop-Helix Transcription Factors 328
Epigenetics 328
DNA Methylation 328
Histone Modifications 328
Acetylation 328
Methylation 329
Stem Cells: Differentiation Versus Pluripotency 329
Summary of Common Signaling Pathways Used during Development 329
Bibliography and Suggested Reading 331
Chapter 1 331
Chapter 2 331
Chapter 3 331
Chapter 4 331
Chapter 5 331
Chapter 6 331
Chapter 7 332
Chapter 8 332
Chapter 9 332
Chapter 10 332
Chapter 11 332
Chapter 12 332
Chapter 13 333
Chapter 14 333
Chapter 15 333
Chapter 16 333
Chapter 17 334
Chapter 18 334
Chapter 19 334
Chapter 20 334
Answers to Clinically Oriented Questions 337
Chapter 1 337
Chapter 2 337
Chapter 3 337
Chapter 4 338
Chapter 5 338
Chapter 6 338
Chapter 7 339
Chapter 8 339
Chapter 9 340
Chapter 10 340
Chapter 11 340
Chapter 12 340
Chapter 13 341
Chapter 14 341
Chapter 15 342
Chapter 16 343
Chapter 17 344
Chapter 18 344
Chapter 19 345
Index 347
A 347
B 348
C 348
D 350
E 350
F 351
G 352
H 352
I 353
J 353
K 353
L 354
M 354
N 355
O 356
P 356
Q 358
R 358
S 358
T 359
U 360
V 360
W 361
X 361
Z 361
Inside Back Cover ibc1