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Pocket Companion to Guyton & Hall Textbook of Medical Physiology E-Book

Pocket Companion to Guyton & Hall Textbook of Medical Physiology E-Book

John E. Hall

(2015)

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Abstract

All of the essential information you need from the world’s foremost medical physiology textbook – right in your pocket! Pocket Companion to Guyton and Hall Textbook of Medical Physiology, 13th Edition, reflects the structure and content of the larger text, helping you recall and easily review the most essential, need-to-know concepts in physiology.

  • Important information can be grasped quickly, thanks to concise, readable text carefully crafted to make physiology easier to understand.
  • New science from the 13th edition of the text keeps you up to date.

Table of Contents

Section Title Page Action Price
Front Cover Cover
IFC1 IFC
IFC2 i
NOTE TO INSTRUCTORS ii
Pocket Companionto Guyton and Hall Textbookof Medical Physiology iii
Copyright iv
Contributors v
Preface vii
Contents ix
Unit I - Introduction to Physiology: The Cell and General Physiology 1
Chapter 1 - Functional Organization of the Human Body and Control of the “Internal Environment” 3
MECHANISMS OF HOMEOSTASIS—MAINTENANCE OF NEARLY CONSTANT INTERNAL ENVIRONMENT (p. 4) 4
CONTROL SYSTEMS OF THE BODY (p. 6) 6
SUMMARY—AUTOMATICITY OF THE BODY (p. 10) 8
Chapter 2 - The Cell and Its Functions 9
ORGANIZATION OF THE CELL (P. 11) 9
PHYSICAL STRUCTURE OF THE CELL (P. 12) 9
FUNCTIONAL SYSTEMS OF THE CELL (P. 19) 14
Chapter 3 - Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction 19
TRANSLATION—SYNTHESIS OF POLYPEPTIDES ON RIBOSOMES FROM GENETIC CODE IN MRNA (P. 33) 23
CONTROL OF GENE FUNCTION AND BIOCHEMICAL ACTIVITY IN CELLS (P. 35) 23
THE DNA–GENETIC SYSTEM CONTROLS CELL REPRODUCTION (P. 37) 25
Unit II - Membrane Physiology,Nerve, and Muscle 29
Chapter 4 - Transport of Substances Through Cell Membranes 31
DIFFUSION (P. 47) 31
“ACTIVE TRANSPORT” OF SUBSTANCES THROUGH MEMBRANES (P. 54) 35
Chapter 5 - Membrane Potentials and Action Potentials 38
BASIC PHYSICS OF MEMBRANE POTENTIALS (P. 61) 38
RESTING MEMBRANE POTENTIAL OF NEURONS (P. 63) 39
NEURON ACTION POTENTIAL (P. 65) 40
PROPAGATION OF THE ACTION POTENTIAL (P. 69) 42
SPECIAL CHARACTERISTICS OF SIGNAL TRANSMISSION IN NERVE TRUNKS (P. 71) 43
Chapter 6 - Contraction of Skeletal Muscle 44
PHYSIOLOGICAL ANATOMY OF SKELETAL MUSCLE (P. 75) 44
GENERAL MECHANISM OF MUSCLE CONTRACTION (P. 77) 45
MOLECULAR MECHANISM OF MUSCLE CONTRACTION (P. 78) 46
ENERGETICS OF MUSCLE CONTRACTION (P. 82) 48
CHARACTERISTICS OF WHOLE MUSCLE CONTRACTION (P. 83) 49
Chapter 7 - Excitation of Skeletal Muscle: Neuromuscular Transmission and Excitation-Contraction Coupling 51
TRANSMISSION OF IMPULSES FROM NERVE ENDINGS TO SKELETAL MUSCLE FIBERS: THE NEUROMUSCULAR JUNCTION (P. 89) 51
MUSCLE ACTION POTENTIAL (P. 93) 53
EXCITATION-CONTRACTION COUPLING (P. 93) 53
Chapter 8 - Excitation and Contraction of Smooth Muscle 55
CONTRACTION OF SMOOTH MUSCLE 55
NERVOUS AND HORMONAL CONTROL OF SMOOTH MUSCLE CONTRACTION (P. 102) 58
Unit III - The Heart 61
Chapter 9 - Cardiac Muscle; The Heart as a Pump and Function of the Heart Valves 63
DISTINGUISHING FEATURES OF CARDIAC MUSCLE COMPARED WITH SKELETAL MUSCLE (P. 109) 63
THE CARDIAC CYCLE (P. 113) 65
REGULATION OF HEART PUMPING (P. 119) 69
Chapter 10 - Rhythmical Excitation of the Heart 71
SPECIALIZED EXCITATORY AND CONDUCTIVE SYSTEM OF THE HEART (P. 123) 71
CONTROL OF EXCITATION AND CONDUCTION IN THE HEART (P. 126) 73
Chapter 11 - The Normal Electrocardiogram 76
ELECTROCARDIOGRAPHIC LEADS (P. 134) 77
Chapter 12 - Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis 79
PRINCIPLES OF VECTORIAL ANALYSIS OF ELECTROCARDIOGRAMS (P. 139) 79
CONDITIONS THAT CAUSE ABNORMAL VOLTAGES OF THE QRS COMPLEX (P. 147) 81
CURRENT OF INJURY (P. 148) 82
ABNORMALITIES IN THE T WAVE (P. 152) 83
Chapter 13 - Cardiac Arrhythmias and Their Electrocardiographic Interpretation 84
ABNORMAL SINUS RHYTHMS (P. 155) 84
ABNORMAL CARDIAC RHYTHMS THAT RESULT FROM IMPULSE CONDUCTION BLOCK (P. 156) 84
PREMATURE CONTRACTIONS (P. 158) 85
PAROXYSMAL TACHYCARDIA (P. 160) 86
VENTRICULAR FIBRILLATION (P. 161) 86
ATRIAL FIBRILLATION (P. 164) 87
Unit IV - The Circulation 89
Chapter 14 - Overview of the Circulation; Biophysics of Pressure, Flow, and Resistance 91
PHYSICAL CHARACTERISTICS OF THE CIRCULATION (P. 169) 91
BASIC PRINCIPLES OF CIRCULATORY FUNCTION (P. 170) 93
INTERRELATIONSHIPS OF PRESSURE, FLOW, AND RESISTANCE (P. 171) 94
Chapter 15 - Vascular Distensibility and Functions of the Arterial and Venous Systems 97
VASCULAR DISTENSIBILITY (P. 179) 97
ARTERIAL PRESSURE PULSATIONS (P. 180) 98
VEINS AND THEIR FUNCTIONS (P. 184) 100
Chapter 16 - The Microcirculation and Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow 103
STRUCTURE OF THE MICROCIRCULATION AND CAPILLARY SYSTEM (P. 189) 103
EXCHANGE OF WATER, NUTRIENTS, AND OTHER SUBSTANCES BETWEEN BLOOD AND INTERSTITIAL FLUID (P. 191) 104
INTERSTITIUM AND INTERSTITIAL FLUID (P. 192) 105
CAPILLARY FLUID FILTRATION IS DETERMINED BY HYDROSTATIC AND COLLOID OSMOTIC PRESSURES AND THE CAPILLARY FILTRATION COEFFICIENT (... 106
THE LYMPHATIC SYSTEM (P. 198) 110
Chapter 17 - Local and Humoral Control of Tissue Blood Flow 113
MECHANISMS OF BLOOD FLOW CONTROL (P. 203) 113
HUMORAL CONTROL OF THE CIRCULATION (P. 212) 121
Chapter 18 - Nervous Regulation of the Circulation and Rapid Control of Arterial Pressure 123
AUTONOMIC NERVOUS SYSTEM (P. 215) 123
ROLE OF THE NERVOUS SYSTEM IN RAPID CONTROL OF ARTERIAL PRESSURE (P. 218) 126
Chapter 19 - Role of the Kidneys in Long-Term Control of Arterial Pressure and in Hypertension: The Integrated System for Arterial Pressure Regulation 131
RENAL–BODY FLUID SYSTEM FOR ARTERIAL PRESSURE CONTROL (P. 227) 131
HYPERTENSION (HIGH BLOOD PRESSURE) (P. 232) 134
THE RENIN-ANGIOTENSIN SYSTEM: ITS ROLE IN ARTERIAL PRESSURE CONTROL (P. 234) 136
SUMMARY OF THE INTEGRATED, MULTIFACETED SYSTEM FOR ARTERIAL PRESSURE REGULATION (P. 241) 140
Chapter 20 - Cardiac Output, Venous Return, and Their Regulation 142
CONTROL OF CARDIAC OUTPUT BY VENOUS RETURN—THE FRANK-STARLING MECHANISM OF THE HEART (P. 245) 142
PATHOLOGICALLY HIGH AND PATHOLOGICALLY LOW CARDIAC OUTPUT (P. 248) 144
A MORE QUANTITATIVE ANALYSIS OF CARDIAC OUTPUT REGULATION (P. 250) 145
METHODS FOR MEASURING CARDIAC OUTPUT 147
Chapter 21 - Muscle Blood Flow and Cardiac Output During Exercise; the Coronary Circulation and Ischemic Heart Disease 148
BLOOD FLOW IN SKELETAL MUSCLE DISTINCTLY INCREASES DURING EXERCISE (P. 259) 148
CORONARY CIRCULATION (P. 262) 149
Chapter 22 - Cardiac Failure 154
CIRCULATORY DYNAMICS IN CARDIAC FAILURE (P. 271) 154
UNILATERAL LEFT HEART FAILURE (P. 275) 157
LOW-OUTPUT CARDIAC FAILURE—CARDIOGENIC SHOCK (P. 275) 157
“HIGH-OUTPUT CARDIAC FAILURE” CAN OCCUR EVEN IN A NORMAL HEART THAT IS OVERLOADED (P. 279) 158
Chapter 23 - Heart Valves and Heart Sounds; Valvular and Congenital Heart Defects 160
HEART SOUNDS (P. 283) 160
ABNORMAL CIRCULATORY DYNAMICS ASSOCIATED WITH CONGENITAL CARDIAC DEFECTS (P. 286) 163
Chapter 24 - Circulatory Shock and Its Treatment 165
SHOCK CAUSED BY HYPOVOLEMIA—HEMORRHAGIC SHOCK (P. 294) 165
PHYSIOLOGY OF TREATMENT IN SHOCK (P. 301) 168
OTHER EFFECTS OF SHOCK ON THE BODY 171
Unit V - The Body Fluids and Kidneys 173
Chapter 25 - The Body Fluid Compartments: Extracellular and Intracellular Fluids; Edema 175
FLUID INTAKE AND OUTPUT ARE BALANCED DURING STEADY-STATE CONDITIONS (P. 305) 175
TOTAL BODY FLUID IS DISTRIBUTED BETWEEN EXTRACELLULAR AND INTRACELLULAR FLUID (P. 306) 175
THE INDICATOR-DILUTION PRINCIPLE CAN BE USED TO MEASURE VOLUMES OF BODY FLUID COMPARTMENTS (P. 308) 177
VOLUME AND OSMOLALITY OF EXTRACELLULAR AND INTRACELLULAR FLUIDS IN ABNORMAL STATES (P. 312) 180
EDEMA: EXCESS FLUID IN THE TISSUES (P. 316) 181
Chapter 26 - The Urinary System: Functional Anatomy and Urine Formation by the Kidneys 185
PHYSIOLOGICAL ANATOMY OF THE KIDNEYS (P. 324) 185
MICTURITION (P. 327) 189
URINE FORMATION RESULTS FROM GLOMERULAR FILTRATION, TUBULAR REABSORPTION, AND TUBULAR SECRETION (P. 331) 190
Chapter 27 - Glomerular Filtration, Renal Blood Flow, and Their Control 192
DETERMINANTS OF THE GFR (P. 337) 192
RENAL BLOOD FLOW (P. 340) 194
GFR AND RENAL BLOOD FLOW ARE CONTROLLED BY NEUROHUMORAL SYSTEMS AND INTRARENAL MECHANISMS (P. 341) 195
GFR AND RENAL BLOOD FLOW ARE AUTOREGULATED DURING CHANGES IN ARTERIAL PRESSURE (P. 342) 196
Chapter 28 - Renal Tubular Reabsorption and Secretion 198
REABSORPTION AND SECRETION ALONG VARIOUS PARTS OF THE NEPHRON (P. 353) 201
REGULATION OF TUBULAR REABSORPTION (P. 359) 204
USE OF CLEARANCE METHODS TO QUANTIFY KIDNEY FUNCTION (P. 365) 207
Chapter 29 - Urine Concentration and Dilution; Regulation of Extracellular Fluid Osmolarity and Sodium Concentration 209
KIDNEYS EXCRETE EXCESS WATER BY FORMING DILUTE URINE (P. 371) 209
KIDNEYS CONSERVE WATER BY EXCRETING CONCENTRATED URINE (P. 373) 211
QUANTIFYING THE RENAL URINE CONCENTRATION AND DILUTION: “FREE WATER” AND OSMOLAR CLEARANCES (P. 380) 212
CONTROL OF EXTRACELLULAR FLUID OSMOLARITY AND SODIUM CONCENTRATION (P. 381) 213
IMPORTANCE OF THIRST IN CONTROLLING EXTRACELLULAR FLUID OSMOLARITY AND SODIUM CONCENTRATION (P. 384) 215
Chapter 30 - Renal Regulation of Potassium, Calcium, Phosphate, and Magnesium; Integration of Renal Mechanisms for Control of Blood Volume and Extracellular Fluid Volume 218
REGULATION OF EXTRACELLULAR FLUID POTASSIUM CONCENTRATION AND POTASSIUM EXCRETION (P. 389) 218
CONTROL OF RENAL CALCIUM EXCRETION AND EXTRACELLULAR CALCIUM ION CONCENTRATION (P. 396) 221
INTEGRATION OF RENAL MECHANISMS FOR CONTROL OF EXTRACELLULAR FLUID (P. 398) 222
IMPORTANCE OF PRESSURE NATRIURESIS AND PRESSURE DIURESIS IN MAINTAINING BODY SODIUM AND FLUID BALANCE (P. 399) 223
DISTRIBUTION OF EXTRACELLULAR FLUID BETWEEN THE INTERSTITIAL SPACES AND VASCULAR SYSTEM (P. 401) 225
NERVOUS AND HORMONAL FACTORS INCREASE THE EFFECTIVENESS OF RENAL–BODY FLUID FEEDBACK CONTROL (P. 402) 225
INTEGRATED RESPONSES TO CHANGES IN SODIUM INTAKE (P. 405) 227
CONDITIONS THAT CAUSE LARGE INCREASES IN BLOOD VOLUME AND EXTRACELLULAR FLUID VOLUME (P. 405) 228
CONDITIONS THAT CAUSE LARGE INCREASES IN EXTRACELLULAR FLUID VOLUME BUT WITH NORMAL BLOOD VOLUME (P. 406) 229
Chapter 31 - Acid-Base Regulation 230
DEFENDING AGAINST CHANGES IN H+ CONCENTRATION: BUFFERS, LUNGS, AND KIDNEYS (P. 410) 230
BUFFERING OF H+ IN THE BODY FLUIDS (P. 410) 231
RESPIRATORY REGULATION OF ACID-BASE BALANCE (P. 414) 233
RENAL CONTROL OF ACID-BASE BALANCE (P. 415) 233
COMBINATION OF EXCESS H+ WITH PHOSPHATE AND AMMONIA BUFFERS IN THE TUBULE GENERATES “NEW” HCO3− (P. 418) 235
QUANTIFYING RENAL ACID-BASE EXCRETION (P. 420) 237
RENAL CORRECTION OF ACIDOSIS—INCREASED EXCRETION OF H+ AND ADDITION OF HCO3− TO THE EXTRACELLULAR FLUID (P. 421) 237
RENAL CORRECTION OF ALKALOSIS—DECREASED TUBULAR SECRETION OF H+ AND INCREASED EXCRETION OF HCO3− (P. 422) 239
Chapter 32 - Diuretics, Kidney Diseases 241
DIURETICS AND THEIR MECHANISMS OF ACTION (P. 427) 241
KIDNEY DISEASES (P. 429) 241
Unit VI - Blood Cells, Immunity, andBlood Coagulation 249
Chapter 33 - Red Blood Cells, Anemia, and Polycythemia 251
ERYTHROPOIETIN REGULATES RED BLOOD CELL PRODUCTION (P. 447) 252
ANEMIAS (P. 452) 254
POLYCYTHEMIA (P. 453) 255
Chapter 34 - Resistance of the Body to Infection: I. Leukocytes, Granulocytes, the Monocyte-Macrophage System, and Inflammation 256
NEUTROPHILS AND MACROPHAGES DEFEND AGAINST INFECTIONS (P. 457) 257
INFLAMMATION: ROLE OF NEUTROPHILS AND MACROPHAGES (P. 460) 258
LEUKEMIAS (P. 463) 260
Chapter 35 - Resistance of the Body to Infection: II. Immunity and Allergy 262
INNATE AND ACQUIRED IMMUNITY 262
SPECIFIC ATTRIBUTES OF THE B-LYMPHOCYTE SYSTEM—HUMORAL IMMUNITY AND THE ANTIBODIES (P. 469) 264
SPECIAL ATTRIBUTES OF THE T-LYMPHOCYTE SYSTEM—ACTIVATED T CELLS AND CELL-MEDIATED IMMUNITY (P. 472) 266
ALLERGY AND HYPERSENSITIVITY (P. 475) 269
Chapter 36 - Blood Types; Transfusion; Tissue and Organ Transplantation 270
O-A-B BLOOD TYPES (P. 477) 270
RH BLOOD TYPES (P. 479) 271
TRANSPLANTATION OF TISSUES AND ORGANS (P. 481) 271
Chapter 37 - Hemostasis and Blood Coagulation 273
MECHANISM OF BLOOD COAGULATION (P. 485) 273
CONDITIONS THAT CAUSE EXCESSIVE BLEEDING IN HUMANS (P. 490) 277
THROMBOEMBOLIC CONDITIONS (P. 491) 278
ANTICOAGULANTS FOR CLINICAL USE (P. 492) 278
Unit VII - Respiration 279
Chapter 38 - Pulmonary Ventilation 281
MECHANICS OF PULMONARY VENTILATION (P. 497) 281
PULMONARY VOLUMES AND CAPACITIES (P. 501) 283
FUNCTIONS OF THE RESPIRATORY PASSAGEWAYS (P. 504) 286
Chapter 39 - Pulmonary Circulation, Pulmonary Edema, Pleural Fluid 288
PHYSIOLOGICAL ANATOMY OF THE PULMONARY CIRCULATORY SYSTEM (P. 509) 288
PRESSURES IN THE PULMONARY SYSTEM (P. 509) 288
REGIONAL BLOOD FLOW IN THE LUNGS DEPENDS ON HYDROSTATIC PRESSURE GRADIENTS CAUSED BY GRAVITY (P. 511) 290
PULMONARY CAPILLARY DYNAMICS (P. 513) 291
Chapter 40 - Principles of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through the Respiratory Membrane 294
EFFECT OF THE VENTILATION-PERFUSION RATIO ON ALVEOLAR GAS CONCENTRATION (P. 524) 298
Chapter 41 - Transport of Oxygen and Carbon Dioxide in Blood and Tissue Fluids 302
Chapter 42 - Regulation of Respiration 308
PERIPHERAL CHEMORECEPTORS FUNCTION TO REGULATE ARTERIAL OXYGEN LEVELS DURING HYPOXEMIA (P. 542) 309
REGULATION OF RESPIRATION DURING EXERCISE (P. 545) 311
Chapter 43 - Respiratory Insufficiency—Pathophysiology, Diagnosis, Oxygen Therapy 312
HYPOXIA AND OXYGEN THERAPY (P. 554) 317
Unit VIII - Aviation, Space, and Deep-Sea Diving Physiology 319
Chapter 44 - Aviation, High Altitude, and Space Physiology 321
EFFECTS OF LOW OXYGEN PRESSURE ON THE BODY (P. 561) 321
Chapter 45 - Physiology of Deep-Sea Diving and Other Hyperbaric Conditions 326
Unit IX - The Nervous System: A. General Principles and Sensory Physiology 331
Chapter 46 - Organization of the Nervous System, Basic Functions of Synapses, and Neurotransmitters 333
GENERAL DESIGN OF THE NERVOUS SYSTEM (P. 577) 333
SYNAPTIC TRANSMISSION EXHIBITS SPECIAL CHARACTERISTICS (P. 592) 339
Chapter 47 - Sensory Receptors, Neuronal Circuits for Processing Information 340
SENSORY RECEPTORS (P. 595) 340
TRANSMISSION AND PROCESSING OF SIGNALS IN NEURONAL POOLS (P. 601) 343
Chapter 48 - Somatic Sensations: I. General Organization, the Tactile and Position Senses 345
CLASSIFICATION OF SOMATIC SENSES (P. 607) 345
Chapter 49 - Somatic Sensations: II. Pain, Headache, and Thermal Sensations 352
FAST AND SLOW CLASSIFICATION OF PAIN SENSATION (P. 621) 352
THREE TYPES OF STIMULI (P. 621) 352
DUAL PATHWAYS FOR TRANSMISSION OF PAIN SIGNALS INTO THE CENTRAL NERVOUS SYSTEM (P. 622) 352
PAIN SUPPRESSION (“ANALGESIA”) SYSTEM IN THE BRAIN AND SPINAL CORD (P. 625) 354
THERMAL SENSATIONS 357
Unit X - The Nervous System: B. The Special Senses 359
Chapter 50 - The Eye: I. Optics of Vision 361
PHYSICAL PRINCIPLES OF OPTICS (P. 635) 361
OPTICS OF THE EYE (P. 638) 362
Chapter 51 - The Eye: II. Receptor and Neural Function of the Retina 366
ANATOMY AND FUNCTION OF THE STRUCTURAL ELEMENTS OF THE RETINA (P. 647) 366
PHOTOCHEMISTRY OF VISION (P. 649) 368
COLOR VISION (P. 654) 370
NEURAL FUNCTION OF THE RETINA (P. 655) 371
Chapter 52 - The Eye: III. Central Neurophysiology of Vision 375
VISUAL PATHWAYS (P. 661) 375
ORGANIZATION AND FUNCTION OF THE VISUAL CORTEX (P. 662) 376
NEURONAL PATTERNS OF STIMULATION DURING ANALYSIS OF THE VISUAL IMAGE (P. 664) 377
AUTONOMIC CONTROL OF ACCOMMODATION AND PUPILLARY APERTURE (P. 669) 380
Chapter 53 - The Sense of Hearing 381
THE TYMPANIC MEMBRANE AND THE OSSICULAR SYSTEM (P. 673) 381
COCHLEA (P. 674) 382
CENTRAL AUDITORY MECHANISMS (P. 679) 385
Chapter 54 - The Chemical Senses—Taste and Smell 387
PRIMARY SENSATIONS OF TASTE (P. 685) 387
SENSE OF SMELL (P. 688) 389
Unit XI - The Nervous System: C. Motorand Integrative Neurophysiology 393
Chapter 55 - Motor Functions of the Spinal Cord; the Cord Reflexes 395
ORGANIZATION OF THE SPINAL CORD FOR MOTOR FUNCTIONS (P. 695) 395
MUSCLE SENSORY RECEPTORS—MUSCLE SPINDLES AND GOLGI TENDON ORGANS—AND THEIR ROLES IN MUSCLE CONTROL (P. 697) 396
FLEXOR REFLEX AND THE WITHDRAWAL REFLEXES (P. 702) 399
CROSSED EXTENSOR REFLEX (P. 703) 399
REFLEXES OF POSTURE AND LOCOMOTION (P. 704) 399
SPINAL CORD TRANSECTION AND SPINAL SHOCK (P. 705) 400
Chapter 56 - Cortical and Brain Stem Control of Motor Function 401
Chapter 57 - Contributions of the Cerebellum and Basal Ganglia to Overall Motor Control 410
THE CEREBELLUM AND ITS MOTOR FUNCTIONS (P. 721) 410
NEURONAL CIRCUIT OF THE CEREBELLUM (P. 722) 411
FUNCTION OF THE CEREBELLUM IN OVERALL MOTOR CONTROL (P. 726) 413
BASAL GANGLIA—THEIR MOTOR FUNCTIONS (P. 730) 415
INTEGRATION OF THE MANY PARTS OF THE TOTAL MOTOR CONTROL SYSTEM (P. 735) 419
Chapter 58 - Cerebral Cortex, Intellectual Functions of the Brain, Learning, and Memory 421
PHYSIOLOGICAL ANATOMY OF THE CEREBRAL CORTEX (P. 737) 421
FUNCTIONS OF SPECIFIC CORTICAL AREAS (P. 738) 421
THOUGHTS, CONSCIOUSNESS, AND MEMORY (P. 745) 425
Chapter 59 - Behavioral and Motivational Mechanisms of the Brain—The Limbic System and the Hypothalamus 429
ACTIVATING—DRIVING SYSTEMS OF THE BRAIN (P. 751) 429
NEUROHORMONAL CONTROL OF BRAIN ACTIVITY (P. 752) 430
LIMBIC SYSTEM (P. 754) 431
SPECIFIC FUNCTIONS OF OTHER PARTS OF THE LIMBIC SYSTEM (P. 759) 434
Chapter 60 - States of Brain Activity—Sleep, Brain Waves, Epilepsy, Psychoses, and Dementia 435
SLEEP (P. 763) 435
BRAIN WAVES (P. 766) 436
EPILEPSY (P. 768) 437
Chapter 61 - The Autonomic Nervous System and the Adrenal Medulla 440
GENERAL ORGANIZATION OF THE AUTONOMIC NERVOUS SYSTEM (P. 773) 440
BASIC CHARACTERISTICS OF SYMPATHETIC AND PARASYMPATHETIC FUNCTION (P. 775) 442
PHARMACOLOGY OF THE AUTONOMIC NERVOUS SYSTEM (P. 784) 447
Chapter 62 - Cerebral Blood Flow, Cerebrospinal Fluid, and Brain Metabolism 450
CEREBRAL BLOOD FLOW (P. 787) 450
CEREBROSPINAL FLUID SYSTEM (P. 790) 452
BRAIN METABOLISM (P. 794) 456
Unit XII - Gastrointestinal Physiology 457
Chapter 63 - General Principles of Gastrointestinal Function—Motility, Nervous Control, and Blood Circulation 459
GENERAL PRINCIPLES OF GASTROINTESTINAL MOTILITY (P. 797) 459
NEURAL CONTROL OF GASTROINTESTINAL FUNCTION: ENTERIC NERVOUS SYSTEM (P. 799) 460
FUNCTIONAL MOVEMENTS IN THE GASTROINTESTINAL TRACT (P. 803) 462
GASTROINTESTINAL BLOOD FLOW: SPLANCHNIC CIRCULATION (P. 804) 464
Chapter 64 - Propulsion and Mixing of Food in the Alimentary Tract 466
INGESTION OF FOOD (P. 807) 466
MOTOR FUNCTIONS OF THE STOMACH (P. 809) 467
MOVEMENTS OF THE SMALL INTESTINE (P. 812) 468
MOVEMENTS OF THE COLON (P. 814) 469
Chapter 65 - Secretory Functions of the Alimentary Tract 471
GENERAL PRINCIPLES OF ALIMENTARY TRACT SECRETION (P. 817) 471
SECRETION OF SALIVA (P. 819) 471
GASTRIC SECRETION (P. 821) 472
PANCREATIC SECRETION (P. 825) 474
BILE SECRETION BY THE LIVER; FUNCTIONS OF THE BILIARY TREE (P. 827) 476
SECRETIONS OF THE SMALL INTESTINE (P. 830) 476
SECRETIONS OF THE LARGE INTESTINE (P. 831) 477
Chapter 66 - Digestion and Absorption in the Gastrointestinal Tract 478
HYDROLYSIS IS THE MECHANISM OF DIGESTION (P. 833) 478
BASIC PRINCIPLES OF GASTROINTESTINAL ABSORPTION (P. 837) 480
ABSORPTION IN THE SMALL INTESTINE (P. 837) 480
ABSORPTION IN THE LARGE INTESTINE: FORMATION OF FECES (P. 841) 483
Chapter 67 - Physiology of Gastrointestinal Disorders 485
DISORDERS OF SWALLOWING AND THE ESOPHAGUS (P. 843) 485
DISORDERS OF THE STOMACH (P. 843) 485
DISORDERS OF THE SMALL INTESTINE (P. 845) 486
DISORDERS OF THE LARGE INTESTINE (P. 846) 487
GENERAL DISORDERS OF THE GASTROINTESTINAL TRACT (P. 847) 487
Unit XIII - Metabolism and Temperature Regulation 489
Chapter 68 - Metabolism of Carbohydrates and Formation of Adenosine Triphosphate 491
TRANSPORT OF GLUCOSE THROUGH THE CELL MEMBRANE (P. 854) 491
STORAGE AND BREAKDOWN OF GLYCOGEN IN LIVER AND MUSCLE (P. 855) 492
RELEASE OF ENERGY FROM GLUCOSE BY THE GLYCOLYTIC PATHWAY (P. 856) 492
FORMATION OF ATP BY OXIDATION OF HYDROGEN: THE PROCESS OF OXIDATIVE PHOSPHORYLATION (P. 858) 493
SUMMARY OF ATP FORMATION DURING BREAKDOWN OF GLUCOSE (P. 859) 495
ANAEROBIC RELEASE OF ENERGY—ANAEROBIC GLYCOLYSIS (P. 860) 496
RELEASE OF ENERGY FROM GLUCOSE BY THE PENTOSE PHOSPHATE PATHWAY (P. 861) 497
FORMATION OF CARBOHYDRATES FROM PROTEINS AND FATS—GLUCONEOGENESIS (P. 861) 497
Chapter 69 - Lipid Metabolism 498
TRANSPORT OF LIPIDS IN THE BODY FLUIDS (P. 863) 498
FAT DEPOSITS (P. 865) 499
USE OF TRIGLYCERIDES FOR ENERGY (P. 866) 500
PHOSPHOLIPIDS AND CHOLESTEROL (P. 870) 503
ATHEROSCLEROSIS (P. 872) 504
Chapter 70 - Protein Metabolism 506
TRANSPORT AND STORAGE OF AMINO ACIDS (P. 875) 506
FUNCTIONAL ROLES OF THE PLASMA PROTEINS (P. 877) 507
HORMONAL REGULATION OF PROTEIN METABOLISM (P. 880) 508
Chapter 71 - The Liver as an Organ 510
HEPATIC VASCULAR AND LYMPH SYSTEMS (P. 881) 510
METABOLIC FUNCTIONS OF THE LIVER (P. 883) 511
MEASUREMENT OF BILIRUBIN IN BILE AS A CLINICAL DIAGNOSTIC TOOL (P. 884) 513
Chapter 72 - Dietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and Minerals 515
METHODS FOR DETERMINING UTILIZATION OF NUTRIENTS BY THE BODY (P. 888) 516
REGULATION OF FOOD INTAKE AND ENERGY STORAGE (P. 889) 516
OBESITY (P. 894) 521
VITAMINS (P. 897) 522
MINERAL METABOLISM (P. 900) 524
Chapter 73 - Energetics and Metabolic Rate 526
ANAEROBIC VERSUS AEROBIC ENERGY (P. 904) 526
METABOLIC RATE (P. 906) 527
Chapter 74 - Body Temperature Regulation and Fever 529
NORMAL BODY TEMPERATURES (p. 911) 529
REGULATION OF BODY TEMPERATURE—ROLE OF THE HYPOTHALAMUS (P. 915) 531
ABNORMALITIES OF BODY TEMPERATURE REGULATION (P. 919) 532
Unit XIV - Endocrinology and Reproduction 535
Chapter 75 - Introduction to Endocrinology 537
COORDINATION OF BODY FUNCTIONS BY CHEMICAL MESSENGERS (P. 925) 537
MAINTENANCE OF HOMEOSTASIS AND REGULATION OF BODY PROCESSES (P. 925) 537
CHEMISTRY, SYNTHESIS, STORAGE, AND SECRETION OF HORMONES (P. 925) 538
MECHANISMS OF ACTION OF HORMONES (P. 930) 539
MEASUREMENT OF HORMONE CONCENTRATIONS IN THE BLOOD (P. 936) 541
Chapter 76 - Pituitary Hormones and Their Control by the Hypothalamus 543
PITUITARY GLAND AND ITS RELATION TO THE HYPOTHALAMUS (P. 939) 543
HYPOTHALAMUS CONTROLS PITUITARY SECRETION (P. 940) 545
PHYSIOLOGICAL FUNCTIONS OF GROWTH HORMONE (P. 942) 547
THE POSTERIOR PITUITARY GLAND AND ITS RELATION TO THE HYPOTHALAMUS (P. 948) 549
Chapter 77 - Thyroid Metabolic Hormones 553
SYNTHESIS AND SECRETION OF THYROID HORMONES (P. 951) 553
FUNCTIONS OF THYROID HORMONES IN THE TISSUES (P. 954) 556
REGULATION OF THYROID HORMONE SECRETION (P. 958) 558
DISEASES OF THE THYROID (P. 960) 559
Chapter 78 - Adrenocortical Hormones 561
CHEMISTRY OF ADRENOCORTICAL\rSECRETION (p. 965) 561
FUNCTIONS OF THE MINERALOCORTICOIDS—ALDOSTERONE (P. 968) 563
FUNCTIONS OF GLUCOCORTICOIDS (P. 972) 565
ADRENAL ANDROGENS (P. 978) 568
ABNORMALITIES OF ADRENOCORTICAL SECRETION (P. 979) 568
Chapter 79 - Insulin, Glucagon, and Diabetes Mellitus 571
CHEMISTRY, SYNTHESIS, AND METABOLISM OF PANCREATIC HORMONES (p. 984) 571
INSULIN AND ITS METABOLIC EFFECTS (P. 983) 572
GLUCAGON AND ITS FUNCTIONS (P. 992) 576
SOMATOSTATIN INHIBITS GLUCAGON AND INSULIN SECRETION (P. 993) 577
DIABETES MELLITUS (P. 994) 577
Chapter 80 - Parathyroid Hormone, Calcitonin, Calcium and Phosphate Metabolism, Vitamin D, Bone, and Teeth 579
CALCIUM AND PHOSPHATE REGULATION IN THE EXTRACELLULAR FLUID AND PLASMA (P. 1001) 579
BONE AND ITS RELATION TO EXTRACELLULAR CALCIUM AND PHOSPHATE (P. 1003) 581
VITAMIN D (P. 1007) 582
PARATHYROID HORMONE (P. 1009) 583
CALCITONIN (P. 1012) 584
OVERALL CONTROL OF CALCIUM ION CONCENTRATION (P. 1013) 584
PATHOPHYSIOLOGY OF PARATHYROID AND BONE DISEASES (P. 1014) 585
PHYSIOLOGY OF THE TEETH (P. 1016) 586
Chapter 81 - Reproductive and Hormonal Functions of the Male (and Function of the Pineal Gland) 588
SPERMATOGENESIS (P. 1021) 588
MALE SEXUAL ACT (P. 1026) 589
MALE SEX HORMONES (P. 1028) 590
MALE INFERTILITY (P. 1026) 592
Chapter 82 - Female Physiology Before Pregnancy and Female Hormones 593
FEMALE HORMONAL SYSTEM (P. 1037) 593
MONTHLY OVARIAN CYCLE (P. 1038) 593
FUNCTIONS OF THE OVARIAN HORMONES—ESTRADIOL AND PROGESTERONE (P. 1042) 596
FEMALE SEXUAL ACT (P. 1051) 600
FEMALE FERTILITY (P. 1052) 600
Chapter 83 - Pregnancy and Lactation 602
TRANSPORT, FERTILIZATION, AND IMPLANTATION OF THE DEVELOPING OVUM (P. 1055) 602
FUNCTION OF THE PLACENTA (P. 1057) 604
HORMONAL FACTORS IN PREGNANCY (P. 1059) 605
PARTURITION—THE PROCESS BY WHICH THE BABY IS BORN (P. 1064) 607
LACTATION (P. 1066) 608
Chapter 84 - Fetal and Neonatal Physiology 610
GROWTH AND FUNCTIONAL DEVELOPMENT OF THE FETUS (P. 1071) 610
ADJUSTMENTS OF THE INFANT TO EXTRAUTERINE LIFE (P. 1073) 611
SPECIAL PROBLEMS IN THE NEONATE (P. 1076) 612
Unit XV - Sports Physiology 615
Chapter 85 - Sports Physiology 617
FEMALE AND MALE ATHLETES (P. 1085) 617
MUSCLES DURING EXERCISE (P. 1085) 617
RESPIRATION DURING EXERCISE (P. 1090) 621
CARDIOVASCULAR SYSTEM DURING EXERCISE (P. 1092) 622
BODY HEAT IN EXERCISE (P. 1094) 623
Index 625
Normal Values for Selected Common Laboratory Measurements IBC