BOOK
Practical Orthopedic Pathology: A Diagnostic Approach E-Book
Andrea T Deyrup | Gene P. Siegal
(2015)
Additional Information
Book Details
Abstract
Apply a systematic pattern recognition approach to achieve more accurate diagnoses of both neoplastic and non-neoplastic diseases of the musculoskeletal system. Andrea Deyrup, MD, PhD and Gene P. Siegal, MD, PhD use a practical, pattern-based organization that helps you efficiently and confidently evaluate even the most challenging histologic specimens.
- Consult this title on your favorite e-reader .
- Compare specimens to commonly seen patterns, categorize them accordingly, and turn directly to in-depth diagnostic guidance using the unique, pattern-based Visual Index at the beginning of the book. Includes guidance on both pathologic and radiologic diagnostic patterns.
- Assess key pathologic and clinical aspects of neoplastic and non-neoplastic conditions with 800 high-quality, full-color images that help you evaluate and interpret both common and rare diseases.
- Find complete coverage of the musculoskeletal system from Normal Bone Anatomy through discussions of all major classifications of disease, both neoplastic and non-neoplastic.
- Progress logically from the histologic pattern, through the appropriate workup, around the pitfalls, and to the best diagnosis.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Inside Front Cover | ifc1 | ||
| Half title page | i | ||
| Series page | ii | ||
| Practical Orthopedic Pathology: A Diagnostic Approach | iii | ||
| Copyright Page | iv | ||
| Dedication | v | ||
| Contributors | vii | ||
| Series Preface | ix | ||
| Preface | xi | ||
| Acknowledgments | xiii | ||
| Table Of Contents | xv | ||
| Pattern-Based Approach to Diagnosis | xvii | ||
| Pattern 1 Osteoid/Bone Deposition and Nonaggressive Radiology | xviii | ||
| Pattern 2 Osteoid/Bone Deposition and Aggressive Radiology within Bone | xx | ||
| Pattern 3 Osteoid/Bone Deposition and Nonaggressive Radiology on Bone Surface | xxii | ||
| Pattern 4 Chondroid Deposition and Nonaggressive Radiology | xxiv | ||
| Pattern 5 Chondroid Deposition and Aggressive Radiology within Bone | xxvi | ||
| Pattern 6 Chondroid or Osteoid/Bone Deposition and Aggressive Radiology on Bone Surface | xxviii | ||
| Pattern 7 Fibrous Lesions Replacing Trabecular Bone | xxx | ||
| Pattern 8 Fibro-osseous Lesions Replacing Trabecular Bone | xxxii | ||
| Pattern 9 Giant Cells Replacing Trabecular Bone | xxxiv | ||
| Pattern 10 Vascular Tumors Replacing Trabecular Bone | xxxvi | ||
| Pattern 11 “Small Cell” Permeation of Trabecular Bone | xxxviii | ||
| Pattern 12 Cystic Lesions | xl | ||
| Pattern 13 Metastasis to Bone | xlii | ||
| Pattern 14 Notochordal Lesions | xliv | ||
| Pattern 15 Crystal Arthropathies | xlvi | ||
| Pattern 16 Joint-Associated Lesions | xlviii | ||
| I The Basics | 1 | ||
| 1 Normal Bone Anatomy | 3 | ||
| Definitions and Synonyms | 3 | ||
| Radiologic Features and Gross Pathology | 3 | ||
| Histopathology | 6 | ||
| Patterns of Bone Alteration in Disease | 12 | ||
| Reactive Bone | 13 | ||
| Periosteal Reactions | 13 | ||
| Patterns of Osseous Abnormalities | 14 | ||
| Suggested Readings | 21 | ||
| References | 21 | ||
| 2 Patterns in Radiology | 23 | ||
| Bone Tumors | 23 | ||
| Lytic Bone Lesions | 23 | ||
| Periosteal Reaction | 23 | ||
| Zone of Transition | 24 | ||
| Summary of Aggressiveness | 25 | ||
| Visible Matrix Mineralization | 25 | ||
| Location | 26 | ||
| Magnetic Resonance Imaging | 28 | ||
| Summary of Lytic Lesions | 28 | ||
| Sclerotic Bone Lesions | 28 | ||
| Medullary Cavity | 28 | ||
| Cortical Lesions | 29 | ||
| Pathognomonic Imaging Signs | 29 | ||
| Enlarged Frame Sign | 30 | ||
| Fallen Fragment Sign | 30 | ||
| Corduroy Sign | 30 | ||
| Rind Sign | 30 | ||
| Cockade Sign | 30 | ||
| Fluid–Fluid Levels | 31 | ||
| Gas within a Lesion | 32 | ||
| Spiculated Margin | 32 | ||
| Periarticular “Bone Islands” | 32 | ||
| Cortical and Medullary Continuity of an Osseous Protuberance | 32 | ||
| Soft Tissue and Joint Masses | 32 | ||
| Magnetic Resonance Evaluation | 32 | ||
| Suggested Readings | 34 | ||
| References | 34 | ||
| 3 Clinical Patterns of Orthopedic Disease | 35 | ||
| Definitions | 35 | ||
| Musculoskeletal Deformity | 35 | ||
| Musculoskeletal Pain | 35 | ||
| Time | 36 | ||
| Location | 36 | ||
| Patterned Relationships | 36 | ||
| Time versus Pain | 36 | ||
| Time versus Deformity | 37 | ||
| Location versus Pain | 40 | ||
| Location versus Deformity | 40 | ||
| Deformity versus Pain | 42 | ||
| Location, Time, Pain, and Deformity | 44 | ||
| Conclusions | 45 | ||
| Suggested Readings | 46 | ||
| References | 47 | ||
| 4 Patterns of Diagnostic Evaluation | 49 | ||
| Clinical Data | 49 | ||
| Decalcification | 52 | ||
| Approach to Histologic Diagnosis | 55 | ||
| Special Techniques | 60 | ||
| Cytogenetics and Molecular Genetics | 63 | ||
| Suggested Readings | 64 | ||
| References | 64 | ||
| II Lesions Characterized Primarily by Osteoid Matrix Production | 65 | ||
| 5 Lesions Characterized by Osteoid Deposition and Nonaggressive Radiology | 67 | ||
| Osteoma/Bone Island | 67 | ||
| Definition and Synonyms | 67 | ||
| Brief Historical Overview | 67 | ||
| Incidence and Demographics | 67 | ||
| Localization and Clinical Manifestations | 67 | ||
| Radiologic Features and Gross Pathology | 68 | ||
| Histopathology | 68 | ||
| Histologic Variants and Grading | 69 | ||
| Differential Diagnosis | 69 | ||
| Genetics | 70 | ||
| Treatment and Prognosis | 70 | ||
| Osteoid Osteoma | 70 | ||
| Definition and Synonyms | 70 | ||
| Brief Historical Overview | 70 | ||
| Incidence and Demographics | 70 | ||
| Localization and Clinical Manifestations | 70 | ||
| Radiologic Features and Gross Pathology | 71 | ||
| Histopathology | 71 | ||
| Differential Diagnosis | 73 | ||
| Treatment and Prognosis | 73 | ||
| Osteoblastoma | 73 | ||
| Definition and Synonyms | 73 | ||
| Brief Historical Overview | 73 | ||
| Incidence and Demographics | 73 | ||
| Localization and Clinical Manifestations | 73 | ||
| Radiologic Features and Gross Pathology | 74 | ||
| Histopathology | 74 | ||
| Histologic Variants and Grading | 75 | ||
| Differential Diagnosis | 76 | ||
| Genetics | 76 | ||
| Treatment and Prognosis | 76 | ||
| Osteopetrosis | 76 | ||
| Definition and Synonyms | 76 | ||
| Brief Historical Overview | 76 | ||
| Incidence and Demographics | 77 | ||
| Localization and Clinical Manifestations | 77 | ||
| Radiologic Features and Gross Pathology | 77 | ||
| Histopathology | 78 | ||
| Treatment and Prognosis | 79 | ||
| Osteopoikilosis | 79 | ||
| Definition and Synonyms | 79 | ||
| Brief Historical Overview | 79 | ||
| Incidence and Demographics | 79 | ||
| Localization and Clinical Manifestations | 79 | ||
| Radiologic Features and Gross Pathology | 79 | ||
| Histopathology | 79 | ||
| Differential Diagnosis | 79 | ||
| Genetics | 79 | ||
| Melorheostosis | 80 | ||
| Definition and Synonyms | 80 | ||
| Brief Historical Overview | 80 | ||
| Incidence and Demographics | 80 | ||
| Localization and Clinical Manifestations | 80 | ||
| Radiologic Features and Gross Pathology | 80 | ||
| Histopathology | 81 | ||
| Treatment and Prognosis | 81 | ||
| Suggested Readings | 82 | ||
| References | 82 | ||
| 6 Lesions Characterized by Osteoid Deposition and Aggressive Radiology Located within Bone | 85 | ||
| Conventional Osteosarcoma | 85 | ||
| Historical Overview | 85 | ||
| Incidence and Demographics | 85 | ||
| Localization and Clinical Manifestations | 86 | ||
| Radiologic Features and Gross Pathology | 86 | ||
| Histopathology | 86 | ||
| Differential Diagnosis | 88 | ||
| Ancillary Diagnostic Studies and Genetics | 93 | ||
| Therapy and Prognosis | 93 | ||
| Telangiectatic Osteosarcoma | 93 | ||
| Historical Overview | 93 | ||
| Incidence and Demographics | 94 | ||
| Localization and Clinical Manifestations | 94 | ||
| Radiologic Features and Gross Pathology | 94 | ||
| Histopathology | 94 | ||
| Differential Diagnosis | 94 | ||
| Ancillary Diagnostic Studies and Genetics | 95 | ||
| Therapy and Prognosis | 95 | ||
| Small Cell Osteosarcoma | 96 | ||
| Historical Overview | 96 | ||
| Incidence and Demographics | 96 | ||
| Localization and Clinical Manifestations | 96 | ||
| Radiologic Features and Gross Pathology | 96 | ||
| Histopathology | 97 | ||
| Differential Diagnosis | 97 | ||
| III Lesions Characterized Primarily by Cartilage Matrix Production | 125 | ||
| 9 Lesions Characterized by Cartilage Deposition and Nonaggressive/Intermediate Radiology | 127 | ||
| Chondroblastoma | 127 | ||
| Definition and Synonyms | 127 | ||
| Brief Historical Overview | 127 | ||
| Incidence and Demographics | 127 | ||
| Localization and Clinical Manifestations | 127 | ||
| Radiologic Features and Gross Pathology | 127 | ||
| Histopathology | 128 | ||
| Differential Diagnosis | 129 | ||
| Ancillary Diagnostic Studies | 130 | ||
| Genetics | 130 | ||
| Treatment and Prognosis | 130 | ||
| Chondromyxoid Fibroma | 130 | ||
| Definition and Synonyms | 130 | ||
| Brief Historical Overview | 130 | ||
| Incidence and Demographics | 130 | ||
| Localization and Clinical Manifestations | 130 | ||
| Radiologic Features and Gross Pathology | 130 | ||
| Histopathology | 130 | ||
| Differential Diagnosis | 132 | ||
| Ancillary Diagnostic Studies | 132 | ||
| Genetics | 132 | ||
| Treatment and Prognosis | 132 | ||
| Enchondroma | 132 | ||
| Definition and Synonyms | 132 | ||
| Incidence and Demographics | 132 | ||
| Localization and Clinical Manifestations | 132 | ||
| Radiologic Features and Gross Pathology | 133 | ||
| Histopathology | 133 | ||
| Histologic Variants and Grading | 134 | ||
| Differential Diagnosis | 134 | ||
| Genetics | 134 | ||
| Treatment and Prognosis | 135 | ||
| Ollier Disease | 135 | ||
| Definition and Synonyms | 135 | ||
| Brief Historical Overview | 135 | ||
| Incidence and Demographics | 135 | ||
| Localization and Clinical Manifestations | 135 | ||
| Radiologic Features and Gross Pathology | 135 | ||
| Maffucci Syndrome: Radiologic Findings | 135 | ||
| Histopathology | 135 | ||
| Differential Diagnosis | 135 | ||
| Genetics | 135 | ||
| Treatment and Prognosis | 136 | ||
| Soft Tissue Chondroma | 136 | ||
| Definition and Synonyms | 136 | ||
| Incidence and Demographics | 136 | ||
| Localization and Clinical Manifestations | 136 | ||
| Radiologic Features and Gross Pathology | 136 | ||
| Histopathology | 136 | ||
| Histologic Variants | 136 | ||
| Differential Diagnosis | 137 | ||
| Ancillary Diagnostic Studies | 137 | ||
| Genetics | 137 | ||
| Treatment and Prognosis | 137 | ||
| Surface/Periosteal Chondroma | 137 | ||
| Definition and Synonyms | 137 | ||
| Brief Historical Overview | 137 | ||
| Incidence and Demographics | 137 | ||
| Localization and Clinical Manifestations | 137 | ||
| Radiologic Features and Gross Pathology | 137 | ||
| Histopathology | 137 | ||
| Differential Diagnosis | 138 | ||
| Genetics | 138 | ||
| Treatment and Prognosis | 138 | ||
| Suggested Readings | 138 | ||
| References | 138 | ||
| 10 Lesions Characterized by Cartilage Deposition and Aggressive Radiology | 141 | ||
| Conventional Chondrosarcoma | 141 | ||
| Definition | 141 | ||
| Brief Historical Overview | 141 | ||
| Incidence and Demographics | 141 | ||
| Localization and Clinical Manifestations | 141 | ||
| Radiologic Features and Gross Pathology | 142 | ||
| Histopathology and Grading | 142 | ||
| Histologic Variants | 143 | ||
| Differential Diagnosis | 143 | ||
| Ancillary Diagnostic Studies | 144 | ||
| Genetics | 144 | ||
| Treatment and Prognosis | 145 | ||
| Clear Cell Chondrosarcoma | 145 | ||
| Definition | 145 | ||
| Brief Historical Overview | 145 | ||
| Incidence and Demographics | 145 | ||
| Localization and Clinical Manifestations | 145 | ||
| Radiologic Features and Gross Pathology | 145 | ||
| Histopathology | 145 | ||
| Histologic Variants and Grading | 145 | ||
| Differential Diagnosis | 145 | ||
| Ancillary Diagnostic Studies | 146 | ||
| Genetics | 146 | ||
| Treatment and Prognosis | 146 | ||
| Dedifferentiated Chondrosarcoma | 146 | ||
| Definition | 146 | ||
| Brief Historical Overview | 146 | ||
| Incidence and Demographics | 146 | ||
| Localization and Clinical Manifestations | 146 | ||
| Radiologic Features and Gross Pathology | 146 | ||
| Histopathology and Grading | 146 | ||
| Differential Diagnosis | 147 | ||
| Genetics | 147 | ||
| Treatment and Prognosis | 147 | ||
| Mesenchymal Chondrosarcoma | 147 | ||
| Definition | 147 | ||
| Brief Historical Overview | 147 | ||
| Incidence and Demographics | 147 | ||
| Localization and Clinical Manifestations | 147 | ||
| Radiologic Features and Gross Pathology | 147 | ||
| Histopathology | 147 | ||
| Histologic Variants and Grading | 148 | ||
| Differential Diagnosis | 148 | ||
| Ancillary Diagnostic Studies | 148 | ||
| Genetics | 148 | ||
| Prognosis and Treatment | 148 | ||
| Suggested Readings | 148 | ||
| References | 148 | ||
| IV Other Lesions | 151 | ||
| 11 Lesions Characterized by Large Numbers of Giant Cells Replacing Trabecular Bone | 153 | ||
| Giant Cell Tumor of Bone | 153 | ||
| Benign Metastasizing Giant Cell Tumor | 155 | ||
| Malignant Giant Cell Tumor | 155 | ||
| Treatment of Giant Cell Tumor of Bone | 156 | ||
| Giant Cell Reparative Granuloma | 156 | ||
| Clinical Settings of Giant Cell Reparative Granuloma | 156 | ||
| Giant Cell Reparative Granuloma of Hyperparathyroidism | 156 | ||
| Giant Cell Reparative Granuloma in the Jaw | 156 | ||
| Giant Cell Reparative Granuloma of the Hands and Feet | 157 | ||
| Giant Cell Reparative Granuloma of Paget Disease | 158 | ||
| Histologic Features of Giant Cell Reparative Granuloma | 158 | ||
| Differential Diagnosis | 158 | ||
| Suggested Readings | 158 | ||
| References | 159 | ||
| 12 Lesions Characterized by a Fibrous Spindle Cell Proliferation Replacing Trabecular Bone | 161 | ||
| Fibro-osseous Lesions | 161 | ||
| Fibrous Dysplasia | 161 | ||
| Overview | 161 | ||
| Incidence and Demographics | 161 | ||
| Localization and Clinical Manifestations | 161 | ||
| Radiologic Features and Gross Pathology | 161 | ||
| Histopathology | 162 | ||
| Differential Diagnosis | 163 | ||
| Genetics | 163 | ||
| Treatment and Prognosis | 163 | ||
| Ossifying Fibroma | 163 | ||
| Overview | 163 | ||
| Incidence and Demographics | 163 | ||
| Localization and Clinical Manifestations | 164 | ||
| Radiologic Features and Gross Pathology | 164 | ||
| Histopathology | 164 | ||
| Differential Diagnosis | 164 | ||
| Ancillary Studies | 164 | ||
| Genetics | 164 | ||
| V Lesions of Joints/Synovium | 287 | ||
| 19 Degenerative Joint Disease | 289 | ||
| Osteoarthritis | 289 | ||
| Definition and Synonyms | 289 | ||
| Brief Historical Overview | 289 | ||
| Incidence and Demographics | 289 | ||
| Localization and Clinical Manifestations | 289 | ||
| Radiologic Features | 290 | ||
| Gross Pathology | 290 | ||
| Histopathology | 291 | ||
| Differential Diagnosis | 293 | ||
| Secondary Osteoarthritis | 294 | ||
| Rheumatoid Arthritis | 294 | ||
| Skeletal Dysplasia | 295 | ||
| Slipped Capital Femoral Epiphysis | 295 | ||
| Avascular Necrosis | 295 | ||
| Neuropathic Joint (Charcot Joint) | 295 | ||
| Septic Arthritis | 296 | ||
| Crystal Deposition Disease | 296 | ||
| Ancillary Diagnostic Studies | 297 | ||
| Genetics | 298 | ||
| Treatment and Prognosis | 298 | ||
| Summary | 299 | ||
| Suggested Readings | 300 | ||
| References | 300 | ||
| 20 Crystal Arthropathies | 303 | ||
| Historical Background | 303 | ||
| Incidence and Demographics | 303 | ||
| Radiologic Features | 303 | ||
| Crystals in Synovial Fluids/Soft Tissue Aspirates | 303 | ||
| Pathology of Crystalline Deposits in Tissues | 306 | ||
| Monosodium Urate Deposits (Gout) | 306 | ||
| Calcium Pyrophosphate Deposits | 307 | ||
| Hydroxyapatite Deposits | 310 | ||
| Handling of Crystal-Containing Sections and Specimens | 311 | ||
| General Comment and Summary | 312 | ||
| Suggested Readings | 312 | ||
| References | 312 | ||
| 21 Joint-Associated Lesions | 313 | ||
| Benign Lesions | 313 | ||
| Rheumatoid Disease | 313 | ||
| Brief Historical Overview | 313 | ||
| Incidence and Demographics | 313 | ||
| Localization and Clinical Manifestations | 313 | ||
| Radiologic Features and Gross Pathology | 313 | ||
| Histopathology | 314 | ||
| Differential Diagnosis | 314 | ||
| Ancillary Diagnostic Studies | 314 | ||
| Genetics | 314 | ||
| Treatment and Prognosis | 315 | ||
| Synovial Hemangioma | 315 | ||
| Brief Historical Overview | 315 | ||
| Localization and Clinical Presentation | 315 | ||
| Radiologic Features and Gross Pathology | 315 | ||
| Histopathology | 315 | ||
| Differential Diagnosis | 316 | ||
| Treatment and Prognosis | 316 | ||
| Lipoma Arborescens | 316 | ||
| Brief Historical Overview | 316 | ||
| Incidence and Demographics | 316 | ||
| Localization and Clinical Manifestations | 316 | ||
| Radiologic Features and Gross Pathology | 316 | ||
| Histopathology | 317 | ||
| Differential Diagnosis | 317 | ||
| Genetics | 317 | ||
| Treatment and Prognosis | 317 | ||
| Giant Cell Tumor of Tendon Sheath (Localized Nodular Tenosynovitis) | 317 | ||
| Brief Historical Overview | 317 | ||
| Incidence and Demographics | 318 | ||
| Radiologic Features and Gross Pathology | 318 | ||
| Localization and Clinical Presentation | 318 | ||
| Histopathology | 318 | ||
| Differential Diagnosis | 318 | ||
| Ancillary Diagnostic Studies | 318 | ||
| Genetics | 319 | ||
| Treatment and Prognosis | 319 | ||
| Diffuse-Type Giant Cell Tumor of Tendon Sheath (Diffuse Tenosynovial Giant Cell Tumor) | 319 | ||
| Brief Historical Overview | 319 | ||
| Incidence and Demographics | 319 | ||
| Localization and Clinical Manifestations | 320 | ||
| Radiologic Features and Gross Pathology | 320 | ||
| Histopathology | 320 | ||
| Differential Diagnosis and Ancillary Diagnostic Studies | 321 | ||
| Histologic Variants | 321 | ||
| Genetics | 321 | ||
| Treatment and Prognosis | 321 | ||
| Synovial Chondromatosis | 321 | ||
| Brief Historical Overview | 321 | ||
| Localization and Clinical Presentation | 321 | ||
| Incidence and Demographics | 321 | ||
| Radiologic Features and Gross Pathology | 322 | ||
| Histopathology | 322 | ||
| Index | 331 | ||
| A | 331 | ||
| B | 331 | ||
| C | 332 | ||
| D | 334 | ||
| E | 334 | ||
| F | 335 | ||
| G | 336 | ||
| H | 336 | ||
| I | 337 | ||
| J | 337 | ||
| K | 337 | ||
| L | 337 | ||
| M | 338 | ||
| N | 339 | ||
| O | 339 | ||
| P | 341 | ||
| R | 342 | ||
| S | 343 | ||
| T | 344 | ||
| U | 344 | ||
| V | 344 | ||
| W | 344 | ||
| X | 344 | ||
| Z | 344 | ||
| Inside Back Cover | ibc1 |