BOOK
Andrews' Diseases of the Skin E-Book
William D. James | Dirk Elston | Timothy Berger | Isaac Neuhaus
(2015)
Additional Information
Book Details
Abstract
Effectively diagnose and treat a wide range of skin conditions with the latest edition of the highly regarded Andrews’ Diseases of the Skin: Clinical Dermatology. The 12th edition of this classic reference, by esteemed authors William D. James, MD, Timothy G. Berger, MD, and Dirk M. Elston, MD, provides state-of-the-art information on newly recognized diseases, new conditions, and unusual variants of well-known diseases, as well as new uses for tried-and-true medications and unique drugs for diseases as disparate as melanoma and rosacea. It’s your ideal go-to resource for clinical dermatology, at every stage of your career.
- Consult this title on your favorite e-reader.
- Still the only one-volume, go-to dermatology text!
- Practice with confidence through the valued authorship of seasoned professionals Dr. William D. James, Dr. Timothy G. Berger, and Dr. Dirk M. Elston.
- Rapidly improve your knowledge of skin conditions through a concise, clinically focused, user-friendly format.
- Obtain thorough guidance on clinical presentation and therapy for a full range of common and rare skin diseases.
- Ensure that you’re up to speed with the hottest topics in dermatology, including drug eruptions from new medications, new therapeutics for melanoma, as well as viral infections, biologic agents, and newly described gene targets for treatment.
- Broaden your knowledge with updated information on serological diagnosis of pemphigus, TNF-I for hidradenitis suppurativa, the use of immunosuppressives for atopic dermatitis, excimer laser for the treatment of vitiligo and much more.
- Quickly access hundreds of new images depicting a wide variety of skin conditions.
- Stay up to date with recent society guidelines, including the latest from the American Academy of Dermatology, covering a variety of conditions such as melanoma and atopic dermatitis.
- Expand your clinical repertoire and meet your patients’ expectations with coverage of the most recent cosmetic agents, their indications, and possible complications.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | cover | ||
| Expert Consult page | IFC2 | ||
| Video Contents | IFC3 | ||
| Andrews' Diseases of the Skin | i | ||
| Copyright Page | iv | ||
| Table Of Contents | v | ||
| Preface and Acknowledgments | vii | ||
| Dedication | viii | ||
| Contributors | ix | ||
| 1 Skin: | 1 | ||
| Epidermis and adnexa | 1 | ||
| Keratinocytes | 1 | ||
| Melanocytes | 3 | ||
| Langerhans cells | 3 | ||
| 2 Cutaneous Signs and Diagnosis | 11 | ||
| Cutaneous signs | 11 | ||
| Primary lesions | 11 | ||
| Macules (maculae, spots) | 11 | ||
| Patches | 11 | ||
| Papules | 11 | ||
| Plaques | 11 | ||
| Nodules | 11 | ||
| Tumors | 11 | ||
| Wheals (hives) | 11 | ||
| Vesicles (blisters) | 12 | ||
| Bullae | 12 | ||
| Pustules | 13 | ||
| Secondary lesions | 13 | ||
| Scales (exfoliation) | 13 | ||
| Crusts (scabs) | 13 | ||
| Excoriations and abrasions (scratch marks) | 13 | ||
| Fissures (cracks, clefts) | 13 | ||
| Erosions | 13 | ||
| Ulcers | 13 | ||
| Scars | 14 | ||
| General diagnosis | 14 | ||
| History | 14 | ||
| Examination | 14 | ||
| Diagnostic details of lesions | 15 | ||
| Distribution | 15 | ||
| Evolution | 15 | ||
| Involution | 15 | ||
| Grouping | 15 | ||
| Configuration | 15 | ||
| Color | 15 | ||
| Texture/consistency | 16 | ||
| Hyperesthesia/anesthesia | 16 | ||
| Hair, nails, and oral mucosa | 16 | ||
| Self-examination | 16 | ||
| References | 16 | ||
| 3 Dermatoses Resulting from Physical Factors | 18 | ||
| Heat injuries | 18 | ||
| Thermal burns | 18 | ||
| Treatment | 18 | ||
| Electrical burns | 19 | ||
| Hot tar burns | 19 | ||
| References | 19 | ||
| Miliaria | 19 | ||
| Miliaria crystallina (sudamina) | 19 | ||
| Miliaria rubra (prickly heat) | 19 | ||
| Miliaria pustulosa | 20 | ||
| Miliaria profunda | 20 | ||
| Postmiliarial hypohidrosis | 20 | ||
| Tropical anhidrotic asthenia | 20 | ||
| Treatment | 20 | ||
| References | 20 | ||
| Erythema ab igne | 20 | ||
| 4 Pruritus and Neurocutaneous Dermatoses | 45 | ||
| Pruritus | 45 | ||
| Patterns of itching | 45 | ||
| Treatment | 45 | ||
| References | 45 | ||
| Internal causes of pruritus | 46 | ||
| References | 46 | ||
| Chronic kidney disease | 46 | ||
| 5 Atopic Dermatitis, Eczema, and Noninfectious Immunodeficiency Disorders | 62 | ||
| Atopic dermatitis | 62 | ||
| Epidemiology | 62 | ||
| Genetic basis and pathogenesis | 62 | ||
| Prevention in high-risk children | 63 | ||
| Food allergy | 63 | ||
| Clinical manifestations | 63 | ||
| Infantile atopic dermatitis | 63 | ||
| Childhood atopic dermatitis | 64 | ||
| Atopic dermatitis in adolescents and adults | 65 | ||
| Associated features and complications | 66 | ||
| Cutaneous stigmata | 66 | ||
| Vascular stigmata | 66 | ||
| Ophthalmologic abnormalities | 66 | ||
| Susceptibility to infection | 66 | ||
| Differential diagnosis | 67 | ||
| Histopathology | 67 | ||
| General management | 67 | ||
| Education and support | 67 | ||
| Barrier repair | 67 | ||
| Antimicrobial therapy | 68 | ||
| Environmental factors | 68 | ||
| Antipruritics | 68 | ||
| Specific treatment modalities | 68 | ||
| Topical corticosteroid therapy | 68 | ||
| Topical calcineurin inhibitors | 68 | ||
| Tar | 69 | ||
| Phototherapy | 69 | ||
| Systemic therapy | 69 | ||
| Systemic corticosteroids | 69 | ||
| Cyclosporine | 69 | ||
| Other immunosuppressive agents | 69 | ||
| Management of acute flare | 69 | ||
| References | 69 | ||
| Eczema | 71 | ||
| Regional eczemas | 71 | ||
| Ear eczema | 71 | ||
| Eyelid dermatitis | 71 | ||
| Breast eczema (nipple eczema) | 72 | ||
| Hand eczema | 72 | ||
| Vesiculobullous hand eczema (pompholyx, dyshidrosis) | 73 | ||
| Chronic vesiculobullous hand eczema | 74 | ||
| Hyperkeratotic hand dermatitis | 74 | ||
| Pulpitis (fingertip hand dermatitis) | 74 | ||
| Treatment | 74 | ||
| Protection | 74 | ||
| Barrier repair | 74 | ||
| Topical agents | 74 | ||
| Phototherapy | 74 | ||
| Botulinum toxin A | 74 | ||
| Systemic agents | 75 | ||
| Workplace modifications | 75 | ||
| Diaper (napkin) dermatitis | 75 | ||
| Circumostomy eczema | 76 | ||
| Autosensitization and conditioned irritability | 76 | ||
| Id reactions | 76 | ||
| Juvenile plantar dermatosis | 76 | ||
| Xerotic eczema | 76 | ||
| Nummular eczema (discoid eczema) | 77 | ||
| Pruritic dermatitis in elderly persons | 77 | ||
| Hormone-induced dermatoses | 78 | ||
| References | 78 | ||
| Immunodeficiency syndromes | 79 | ||
| 6 Contact Dermatitis and Drug Eruptions | 90 | ||
| Contact dermatitis | 90 | ||
| Irritant contact dermatitis | 90 | ||
| Alkalis | 90 | ||
| Acids | 90 | ||
| Airbag dermatitis | 91 | ||
| Other irritants | 91 | ||
| Fiberglass dermatitis | 91 | ||
| Dusts | 91 | ||
| Capsaicin | 91 | ||
| Tear gas dermatitis | 91 | ||
| Chloracne | 92 | ||
| Hydrocarbons | 92 | ||
| Solvents | 93 | ||
| References | 93 | ||
| Allergic contact dermatitis | 93 | ||
| Testing for sensitivity | 94 | ||
| Patch test | 94 | ||
| Provocative use test | 94 | ||
| Photopatch test | 94 | ||
| Regional predilection | 94 | ||
| Head and neck | 94 | ||
| Trunk | 95 | ||
| Arms | 95 | ||
| Hands | 95 | ||
| Abdomen | 95 | ||
| Groin | 95 | ||
| Lower extremities | 95 | ||
| References | 95 | ||
| Dermatitis resulting from plants | 95 | ||
| Toxicodendron (poison ivy) | 96 | ||
| Other Toxicodendron-related dermatitides | 97 | ||
| Flowers and houseplants | 97 | ||
| Fruit and vegetables | 97 | ||
| Trees | 97 | ||
| Tree-associated plants | 98 | ||
| Pollens and seeds | 98 | ||
| Marine plants | 98 | ||
| Plant-associated dermatitis | 98 | ||
| Plant derivatives | 98 | ||
| References | 98 | ||
| Dermatitis from clothing | 99 | ||
| References | 99 | ||
| Shoe dermatitis | 100 | ||
| References | 100 | ||
| Dermatitis from metals and metal salts | 100 | ||
| Black dermatographism | 100 | ||
| Nickel | 101 | ||
| Chromium | 101 | ||
| Mercury | 102 | ||
| Cobalt | 102 | ||
| Gold | 102 | ||
| Other metals | 102 | ||
| 7 Erythema and Urticaria | 136 | ||
| Flushing | 136 | ||
| 8 Connective Tissue Diseases | 153 | ||
| Lupus erythematosus | 153 | ||
| Chronic cutaneous lupus erythematosus | 153 | ||
| Discoid lupus erythematosus | 153 | ||
| Localized discoid lupus erythematosus | 153 | ||
| Generalized discoid lupus erythematosus | 153 | ||
| Childhood discoid lupus erythematosus | 153 | ||
| Histology | 153 | ||
| Differential diagnosis | 155 | ||
| Hypertrophic lupus erythematosus | 155 | ||
| Lupus erythematosus–lichen planus overlap syndrome | 155 | ||
| Chilblain lupus erythematosus | 155 | ||
| Tumid lupus erythematosus | 155 | ||
| Lupus erythematosus panniculitis (lupus erythematosus profundus) | 156 | ||
| Subacute cutaneous lupus erythematosus | 156 | ||
| Histopathology | 156 | ||
| Neonatal lupus erythematosus | 157 | ||
| Complement deficiency syndromes | 157 | ||
| Systemic lupus erythematosus | 157 | ||
| Cutaneous manifestations | 157 | ||
| Systemic manifestations | 159 | ||
| Childhood systemic lupus erythematosus | 160 | ||
| Pregnancy | 160 | ||
| Etiology | 160 | ||
| Laboratory findings | 160 | ||
| Immunologic findings | 160 | ||
| Differential diagnosis | 161 | ||
| Treatment | 161 | ||
| Local treatment | 161 | ||
| Systemic treatment | 161 | ||
| Antimalarials | 161 | ||
| Corticosteroids | 161 | ||
| Immunosuppressive therapy | 162 | ||
| Other therapy | 162 | ||
| References | 162 | ||
| Dermatomyositis | 162 | ||
| Skin findings | 162 | ||
| Muscle changes | 164 | ||
| Diagnostic criteria | 164 | ||
| Associated diseases | 164 | ||
| Neoplasia with dermatomyositis | 164 | ||
| Childhood dermatomyositis | 164 | ||
| Etiology | 165 | ||
| Incidence | 165 | ||
| Histopathology | 165 | ||
| Laboratory findings | 165 | ||
| Differential diagnosis | 165 | ||
| Treatment | 165 | ||
| Prognosis | 166 | ||
| References | 166 | ||
| Scleroderma | 166 | ||
| Cutaneous types | 166 | ||
| Localized morphea | 166 | ||
| Morphea–lichen sclerosus et atrophicus overlap | 167 | ||
| Generalized morphea | 167 | ||
| Atrophoderma of Pasini and Pierini | 167 | ||
| Pansclerotic morphea | 167 | ||
| Morphea profunda | 167 | ||
| Linear scleroderma | 167 | ||
| Systemic types | 167 | ||
| CREST syndrome | 167 | ||
| Progressive systemic sclerosis | 168 | ||
| Skin findings | 168 | ||
| Internal involvement | 169 | ||
| Prognosis | 169 | ||
| Laboratory findings | 169 | ||
| Radiographic findings | 169 | ||
| Histology | 170 | ||
| Differential diagnosis | 170 | ||
| Pathogenesis | 170 | ||
| Treatment | 171 | ||
| References | 171 | ||
| Eosinophilic fasciitis | 172 | ||
| References | 172 | ||
| Mixed connective tissue disease | 172 | ||
| 9 Mucinoses | 179 | ||
| Lichen myxedematosus | 179 | ||
| Generalized lichen myxedematosus | 179 | ||
| Localized lichen myxedematosus | 180 | ||
| Discrete papular lichen myxedematosus | 180 | ||
| Acral persistent papular mucinosis | 181 | ||
| Self-healing papular mucinosis | 181 | ||
| Papular mucinosis of infancy | 181 | ||
| Nodular lichen myxedematosus | 181 | ||
| Atypical or intermediate lichen myxedematosus | 181 | ||
| References | 181 | ||
| Scleredema | 182 | ||
| References | 182 | ||
| Reticular erythematous mucinosis (REM syndrome, plaquelike cutaneous mucinosis) | 183 | ||
| References | 183 | ||
| Follicular mucinosis (alopecia mucinosa) | 183 | ||
| 10 Seborrheic Dermatitis, Psoriasis, Recalcitrant Palmoplantar Eruptions, Pustular Dermatitis, and Erythroderma | 185 | ||
| Seborrheic dermatitis | 185 | ||
| Clinical features | 185 | ||
| Etiology and pathogenesis | 185 | ||
| Histology | 185 | ||
| Differential diagnosis | 185 | ||
| Treatment | 186 | ||
| References | 186 | ||
| Psoriasis | 187 | ||
| Clinical features | 187 | ||
| Types | 187 | ||
| Seborrheic-like psoriasis | 187 | ||
| Inverse psoriasis | 188 | ||
| “Napkin” psoriasis | 188 | ||
| Psoriatic arthritis | 188 | ||
| Guttate psoriasis | 188 | ||
| Generalized pustular psoriasis (von Zumbusch psoriasis) | 188 | ||
| Acrodermatitis continua (of Hallopeau) | 189 | ||
| Impetigo herpetiformis | 189 | ||
| Keratoderma blennorrhagicum (Reiter syndrome) | 189 | ||
| Erythrodermic psoriasis | 189 | ||
| Course | 189 | ||
| Inheritance | 190 | ||
| Epidemiology | 190 | ||
| Pathogenesis | 190 | ||
| Streptococci | 191 | ||
| Stress | 191 | ||
| Drug-induced psoriasis | 191 | ||
| Pathology | 191 | ||
| Clinical differential diagnosis | 191 | ||
| Treatment | 192 | ||
| Topical treatment | 192 | ||
| Corticosteroids | 192 | ||
| Tars | 192 | ||
| Anthralin | 192 | ||
| Tazarotene | 192 | ||
| Calcipotriene | 192 | ||
| Macrolactams (calcineurin inhibitors) | 192 | ||
| Salicylic acid | 192 | ||
| Ultraviolet light | 192 | ||
| Goeckerman technique | 192 | ||
| Ingram technique | 193 | ||
| PUVA therapy | 193 | ||
| Surgical treatment | 193 | ||
| Hyperthermia | 193 | ||
| Occlusive treatment | 193 | ||
| Systemic treatment | 193 | ||
| Corticosteroids | 193 | ||
| Methotrexate | 193 | ||
| Cyclosporine | 193 | ||
| Diet | 194 | ||
| Oral antimicrobial therapy | 194 | ||
| Retinoids | 194 | ||
| Dapsone | 194 | ||
| Biologic agents | 194 | ||
| Percentage of patients clearing with each drug | 194 | ||
| Risks | 194 | ||
| Combination therapy | 194 | ||
| Evolving therapies | 195 | ||
| References | 195 | ||
| Reactive arthritis with conjunctivitis/urethritis/diarrhea (Reiter syndrome) | 195 | ||
| Clinical features | 195 | ||
| 11 Pityriasis Rosea, Pityriasis Rubra Pilaris, and Other Papulosquamous and Hyperkeratotic Diseases | 199 | ||
| Small plaque parapsoriasis | 199 | ||
| 12 Lichen Planus and Related Conditions | 209 | ||
| Lichen planus | 209 | ||
| Linear lichen planus | 210 | ||
| Annular and annular atrophic lichen planus | 211 | ||
| Hypertrophic lichen planus | 211 | ||
| Erosive/ulcerative/mucosal lichen planus | 211 | ||
| Cancer risk and lichen planus | 212 | ||
| Hepatitis-associated lichen planus | 213 | ||
| Bullous lichen planus | 213 | ||
| Pathogenesis and histology | 213 | ||
| Differential diagnosis | 214 | ||
| Treatment | 214 | ||
| References | 214 | ||
| Adnexal lichen planus: follicular lichen planus (lichen planopilaris) and acrosyringeal lichen planus | 217 | ||
| References | 217 | ||
| Lichen planus pigmentosus/actinicus | 217 | ||
| Erythema dyschromicum perstans | 218 | ||
| Idiopathic eruptive macular pigmentation | 218 | ||
| References | 218 | ||
| Keratosis lichenoides chronica | 218 | ||
| References | 219 | ||
| Lichen nitidus | 219 | ||
| Clinical features | 219 | ||
| References | 220 | ||
| Lichen striatus | 220 | ||
| References | 221 | ||
| Lichen sclerosus (lichen sclerosus et atrophicus) | 221 | ||
| Lichen sclerosus and cancer | 222 | ||
| Histopathology | 223 | ||
| Differential diagnosis | 223 | ||
| Treatment | 223 | ||
| References | 223 | ||
| 13 Acne | 225 | ||
| Acne vulgaris | 225 | ||
| Clinical features | 225 | ||
| Pathogenesis | 225 | ||
| Pathology | 227 | ||
| Treatment | 227 | ||
| General principles | 227 | ||
| Medical therapy | 228 | ||
| Topical treatment | 228 | ||
| Topical retinoids | 228 | ||
| Benzoyl peroxide | 228 | ||
| Topical antibacterials | 228 | ||
| Sulfur, sodium sulfacetamide, resorcin, and salicylic acid | 228 | ||
| Azelaic acid | 229 | ||
| Combination topical therapy | 229 | ||
| Oral antibiotics | 229 | ||
| Tetracycline derivatives | 229 | ||
| Doxycycline. | 229 | ||
| Minocycline. | 229 | ||
| Amoxicillin | 229 | ||
| Clindamycin | 229 | ||
| Other antibiotics | 229 | ||
| Bacterial resistance | 229 | ||
| Hormonal therapy | 230 | ||
| Oral contraceptives | 230 | ||
| Spironolactone | 230 | ||
| Dexamethasone | 230 | ||
| Prednisone | 230 | ||
| Other hormonal agents | 230 | ||
| Oral retinoid therapy | 230 | ||
| Isotretinoin | 230 | ||
| Tumor necrosis factor inhibitors | 232 | ||
| Intralesional corticosteroids | 232 | ||
| Physical modalities | 232 | ||
| Complications | 232 | ||
| References | 232 | ||
| Acne conglobata | 233 | ||
| References | 233 | ||
| Acne fulminans | 233 | ||
| 14 Bacterial Infections | 245 | ||
| Infections Caused by Gram-Positive Organisms | 245 | ||
| Staphylococcal Infections | 245 | ||
| Superficial pustular folliculitis (impetigo of Bockhart) | 245 | ||
| Sycosis vulgaris (sycosis barbae) | 245 | ||
| Folliculitis | 246 | ||
| Treatment | 246 | ||
| Furunculosis | 246 | ||
| Hospital furunculosis | 247 | ||
| Treatment | 247 | ||
| Chronic furunculosis | 247 | ||
| Pyogenic paronychia | 247 | ||
| Botryomycosis | 248 | ||
| Blastomycosis-like pyoderma | 249 | ||
| Pyomyositis | 249 | ||
| Impetigo contagiosa | 249 | ||
| Treatment | 250 | ||
| Bullous impetigo | 250 | ||
| Staphylococcal scalded skin syndrome | 250 | ||
| Gram-positive toxic shock syndromes | 251 | ||
| Streptococcal skin infections | 252 | ||
| Ecthyma | 252 | ||
| Scarlet fever | 252 | ||
| Recurrent toxin-mediated perineal erythema | 253 | ||
| Erysipelas | 253 | ||
| Cellulitis | 254 | ||
| Chronic recurrent erysipelas, chronic lymphangitis | 254 | ||
| Necrotizing fasciitis | 254 | ||
| Blistering distal dactylitis | 255 | ||
| Perianal dermatitis | 255 | ||
| Streptococcal intertrigo | 255 | ||
| Erythema marginatum | 255 | ||
| Group B streptococcal infection | 256 | ||
| Streptococcus iniae infections | 256 | ||
| Miscellaneous gram-positive skin infections | 257 | ||
| Erysipeloid of Rosenbach | 257 | ||
| Treatment | 257 | ||
| Pneumococcal cellulitis | 257 | ||
| Anthrax | 257 | ||
| Listeriosis | 258 | ||
| Cutaneous diphtheria | 258 | ||
| Corynebacterium jeikeium sepsis | 259 | ||
| Erythrasma | 259 | ||
| Arcanobacterium haemolyticum infection | 259 | ||
| Intertrigo | 260 | ||
| Pitted keratolysis | 260 | ||
| Clostridial infections and gangrene of the skin | 260 | ||
| Gas gangrene (clostridial myonecrosis) | 260 | ||
| Chronic undermining burrowing ulcers (Meleney gangrene) | 261 | ||
| Fournier gangrene of the penis or scrotum | 261 | ||
| Actinomycosis | 261 | ||
| Nocardiosis | 262 | ||
| Infections Caused by Gram-Negative Organisms | 262 | ||
| Pseudomonas infections | 262 | ||
| Ecthyma gangrenosum | 262 | ||
| Green nail syndrome | 263 | ||
| Gram-negative toe web infection | 263 | ||
| Blastomycosis-like pyoderma | 264 | ||
| Pseudomonas aeruginosa folliculitis (hot tub folliculitis) | 264 | ||
| External otitis | 264 | ||
| Gram-negative folliculitis | 265 | ||
| Malacoplakia (malakoplakia) | 265 | ||
| Haemophilus influenzae cellulitis | 265 | ||
| Chancroid | 265 | ||
| Treatment | 266 | ||
| Granuloma inguinale (granuloma venereum, donovanosis) | 266 | ||
| Treatment | 267 | ||
| Gonococcal dermatitis | 267 | ||
| Gonococcemia | 268 | ||
| Meningococcemia | 268 | ||
| Vibrio vulnificus infection | 269 | ||
| Chromobacteriosis and Aeromonas infections | 269 | ||
| Salmonellosis | 269 | ||
| Shigellosis | 270 | ||
| Helicobacter cellulitis | 270 | ||
| Rhinoscleroma | 270 | ||
| Treatment | 271 | ||
| Pasteurellosis | 271 | ||
| Dog and human bite pathogens | 271 | ||
| Glanders | 271 | ||
| Melioidosis | 272 | ||
| Infections caused by Bartonella | 272 | ||
| Cat-scratch disease | 272 | ||
| Trench fever | 273 | ||
| Bacillary angiomatosis | 273 | ||
| Treatment | 274 | ||
| Oroya fever and verruga peruana | 274 | ||
| Plague | 275 | ||
| Rat-bite fever | 275 | ||
| Tularemia | 275 | ||
| Brucellosis | 276 | ||
| Rickettsial Diseases | 277 | ||
| Typhus group | 277 | ||
| Epidemic typhus | 277 | ||
| Endemic typhus | 277 | ||
| Scrub typhus | 277 | ||
| Spotted fever group | 278 | ||
| Rocky Mountain spotted fever | 278 | ||
| Mediterranean spotted fever | 278 | ||
| Rickettsialpox | 278 | ||
| Ehrlichiosis | 279 | ||
| Leptospirosis | 279 | ||
| Borreliosis | 280 | ||
| Lyme disease | 280 | ||
| Treatment | 281 | ||
| Acrodermatitis chronica atrophicans | 282 | ||
| Mycoplasma | 282 | ||
| Chlamydial infections | 283 | ||
| Lymphogranuloma venereum | 283 | ||
| Treatment | 284 | ||
| 15 Diseases Resulting from Fungi and Yeasts | 285 | ||
| Superficial and Deep Mycoses | 285 | ||
| Susceptibility and prevalence | 285 | ||
| Antifungal therapy | 285 | ||
| The Superficial Mycoses | 286 | ||
| Tinea capitis | 286 | ||
| Favus | 286 | ||
| Pathogenesis and natural history | 287 | ||
| Diagnosis | 287 | ||
| Wood’s light | 287 | ||
| Laboratory examination | 287 | ||
| Trichophyton tonsurans | 287 | ||
| Trichophyton mentagrophytes | 287 | ||
| Trichophyton verrucosum | 287 | ||
| Microsporum audouinii | 287 | ||
| Microsporum canis | 287 | ||
| Differential diagnosis | 288 | ||
| Treatment | 288 | ||
| Prognosis | 288 | ||
| Dermatophytids | 288 | ||
| Tinea barbae | 288 | ||
| Diagnosis | 289 | ||
| Differential diagnosis | 289 | ||
| Treatment | 289 | ||
| Tinea faciei | 289 | ||
| Tinea corporis (tinea circinata) | 289 | ||
| Diagnosis | 290 | ||
| Treatment | 290 | ||
| Other forms of tinea corporis | 290 | ||
| Fungal folliculitis (Majocchi granuloma) and tinea incognito | 290 | ||
| Tinea imbricata (Tokelau) | 290 | ||
| Tinea cruris | 290 | ||
| Etiology and differential diagnosis | 291 | ||
| Treatment | 291 | ||
| Tinea of hands and feet | 291 | ||
| Diagnosis | 292 | ||
| Prophylaxis | 292 | ||
| Treatment | 292 | ||
| Onychomycosis (tinea unguium) | 292 | ||
| Diagnosis | 293 | ||
| Differential diagnosis | 294 | ||
| Treatment | 294 | ||
| Candidiasis | 295 | ||
| Diagnosis | 295 | ||
| Topical anticandidal agents | 295 | ||
| Other agents | 295 | ||
| Oral candidiasis (thrush) | 295 | ||
| Perlèche | 296 | ||
| Candidal vulvovaginitis | 296 | ||
| Candidal intertrigo | 296 | ||
| Diaper candidiasis | 297 | ||
| Congenital cutaneous candidiasis | 297 | ||
| Perianal candidiasis | 297 | ||
| Candidal paronychia | 297 | ||
| Erosio interdigitalis blastomycetica | 297 | ||
| Chronic mucocutaneous candidiasis | 297 | ||
| Systemic candidiasis | 298 | ||
| Candidid | 299 | ||
| Antibiotic (iatrogenic) candidiasis | 299 | ||
| Geotrichosis | 299 | ||
| Tinea nigra | 299 | ||
| Piedra | 300 | ||
| Tinea versicolor (pityriasis versicolor) | 300 | ||
| Diagnosis | 300 | ||
| Differential diagnosis | 301 | ||
| Treatment | 301 | ||
| Pityrosporum folliculitis | 301 | ||
| The Deep Mycoses | 301 | ||
| Coccidioidomycosis | 302 | ||
| Primary pulmonary coccidioidomycosis | 302 | ||
| Disseminated coccidioidomycosis (coccidioidal granuloma) | 302 | ||
| Primary cutaneous coccidioidomycosis | 302 | ||
| Etiology and pathology | 302 | ||
| Culture | 303 | ||
| Epidemiology | 303 | ||
| Differential diagnosis | 303 | ||
| Immunology | 303 | ||
| Treatment | 303 | ||
| Histoplasmosis | 303 | ||
| Primary pulmonary histoplasmosis | 303 | ||
| Progressive disseminated histoplasmosis | 304 | ||
| Primary cutaneous histoplasmosis | 304 | ||
| African histoplasmosis | 304 | ||
| Etiology and pathology | 304 | ||
| Epidemiology | 305 | ||
| Immunology | 305 | ||
| Treatment | 305 | ||
| Cryptococcosis | 305 | ||
| Etiology and pathology | 306 | ||
| Epidemiology | 306 | ||
| Immunology | 306 | ||
| Mycology | 306 | ||
| Treatment | 306 | ||
| North American blastomycosis | 306 | ||
| Etiology and pathology | 307 | ||
| Epidemiology | 307 | ||
| Immunology | 307 | ||
| Differential diagnosis | 307 | ||
| 16 Mycobacterial Diseases | 319 | ||
| Tuberculosis | 319 | ||
| Epidemiology | 319 | ||
| Tuberculin testing | 320 | ||
| BCG vaccination | 320 | ||
| Inoculation cutaneous tuberculosis from exogenous source | 321 | ||
| Primary inoculation tuberculosis (primary tuberculous complex, tuberculous chancre) | 321 | ||
| Paucibacillary cutaneous tuberculosis from exogenous or endogenous source in persons with high immunity | 321 | ||
| Tuberculosis verrucosa cutis | 321 | ||
| Differential diagnosis | 322 | ||
| Lupus vulgaris | 322 | ||
| Cutaneous tuberculosis from endogenous source by direct extension (scrofuloderma and periorificial tuberculosis) | 323 | ||
| Cutaneous tuberculosis from hematogenous spread | 323 | ||
| Miliary (disseminated) tuberculosis | 323 | ||
| Metastatic tuberculous abscess, ulceration, or cellulitis | 324 | ||
| Sporotrichoid tuberculosis | 324 | ||
| Tuberculous mastitis | 324 | ||
| Tuberculids | 324 | ||
| Papulonecrotic tuberculid | 324 | ||
| Lichen scrofulosorum | 324 | ||
| Erythema induratum and vascular reactions caused by tuberculosis (nodular tuberculid and nodular granulomatous phlebitis) | 325 | ||
| Diagnosis of cutaneous tuberculosis | 325 | ||
| Treatment | 325 | ||
| References | 325 | ||
| Atypical mycobacteriosis | 326 | ||
| Classification of mycobacteria | 326 | ||
| Swimming pool granuloma (aquarium granuloma) | 327 | ||
| Buruli ulcer | 327 | ||
| Other atypical mycobacterial infections | 328 | ||
| Mycobacterium haemophilum | 328 | ||
| Rapidly growing mycobacteria | 328 | ||
| Mycobacterium avium-intracellulare complex | 329 | ||
| Mycobacterium kansasii | 329 | ||
| References | 329 | ||
| 17 Hansen’s Disease | 331 | ||
| Epidemiology | 331 | ||
| The infectious agent | 331 | ||
| Diagnosis | 332 | ||
| Classification | 332 | ||
| Early and indeterminate Hansen’s disease | 333 | ||
| Tuberculoid leprosy | 333 | ||
| Borderline tuberculoid (BT) leprosy | 333 | ||
| Borderline borderline (BB) leprosy | 334 | ||
| Borderline lepromatous (BL) leprosy | 334 | ||
| Lepromatous leprosy | 334 | ||
| Histoid leprosy | 335 | ||
| Nerve involvement | 335 | ||
| Ocular involvement | 336 | ||
| Mucous membrane involvement | 336 | ||
| Visceral involvement | 337 | ||
| Special clinical considerations and Hansen’s disease | 337 | ||
| Pregnancy | 337 | ||
| Human immunodeficiency virus | 337 | ||
| Organ transplantation | 337 | ||
| Immunopathogenesis | 337 | ||
| Histopathology | 337 | ||
| Tuberculoid leprosy | 337 | ||
| Borderline tuberculoid leprosy | 338 | ||
| Borderline leprosy | 338 | ||
| Borderline lepromatous leprosy | 338 | ||
| Lepromatous leprosy | 338 | ||
| Reactional states | 338 | ||
| Type 1 reactions (reversal, lepra, and downgrading reactions) | 338 | ||
| Type 2 reactions (erythema nodosum leprosum) | 338 | ||
| Lucio’s phenomenon | 339 | ||
| Treatment | 339 | ||
| Adjunctive treatments | 340 | ||
| Management of reactions | 340 | ||
| Prevention | 341 | ||
| References | 341 | ||
| 18 Syphilis, Yaws, Bejel, and Pinta | 343 | ||
| Syphilis | 343 | ||
| Serologic tests | 344 | ||
| Biologic false-positive test results | 344 | ||
| Cutaneous syphilis | 345 | ||
| Chancre (primary stage) | 345 | ||
| Secondary syphilis | 346 | ||
| Cutaneous lesions | 346 | ||
| Macular eruptions | 346 | ||
| Papular eruptions | 347 | ||
| Relapsing secondary syphilis | 348 | ||
| Systemic involvement | 348 | ||
| Histopathology | 348 | ||
| Diagnosis and differential diagnosis | 349 | ||
| Latent syphilis | 349 | ||
| Late syphilis | 349 | ||
| Tertiary cutaneous syphilis | 349 | ||
| Late osseous syphilis | 350 | ||
| Neurosyphilis | 350 | ||
| Early neurosyphilis | 351 | ||
| Meningovascular neurosyphilis | 351 | ||
| Late (parenchymatous) neurosyphilis | 351 | ||
| Late cardiovascular syphilis | 351 | ||
| Congenital syphilis | 351 | ||
| Early congenital syphilis | 351 | ||
| Late congenital syphilis | 352 | ||
| Inflammatory lesions | 352 | ||
| Malformations (stigmata) | 352 | ||
| Diagnosis | 352 | ||
| Treatment | 353 | ||
| Jarisch-Herxheimer or Herxheimer reaction | 353 | ||
| Treatment of sex partners | 354 | ||
| Serologic testing after treatment | 354 | ||
| Syphilis and HIV disease | 354 | ||
| References | 354 | ||
| Nonvenereal treponematoses: yaws, endemic syphilis, and pinta | 356 | ||
| Yaws (pian, frambesia, bouba) | 356 | ||
| Early yaws | 356 | ||
| Late yaws | 357 | ||
| Histopathology | 357 | ||
| Diagnosis | 357 | ||
| Endemic syphilis (bejel) | 357 | ||
| Pinta | 357 | ||
| Primary stage | 357 | ||
| Secondary stage | 357 | ||
| Late dyschromic stage | 358 | ||
| Histopathology | 358 | ||
| Treatment | 358 | ||
| References | 358 | ||
| 19 Viral Diseases | 359 | ||
| Herpesvirus group | 359 | ||
| Herpes simplex | 359 | ||
| Orolabial herpes | 360 | ||
| Herpetic sycosis | 361 | ||
| Herpes gladiatorum | 361 | ||
| Herpetic whitlow | 362 | ||
| Herpetic keratoconjunctivitis | 362 | ||
| Genital herpes | 362 | ||
| Intrauterine and neonatal herpes simplex | 363 | ||
| Eczema herpeticum (Kaposi varicelliform eruption) | 365 | ||
| Immunocompromised patients | 365 | ||
| Histopathology | 366 | ||
| Differential diagnosis | 366 | ||
| References | 367 | ||
| Varicella | 368 | ||
| Treatment | 369 | ||
| Pregnant women and neonates | 369 | ||
| Varicella vaccine | 369 | ||
| Modified varicella-like syndrome | 370 | ||
| Immunocompromised patients | 370 | ||
| References | 370 | ||
| Zoster (shingles, herpes zoster) | 371 | ||
| Disseminated herpes zoster | 372 | ||
| Ophthalmic zoster | 372 | ||
| Other complications | 372 | ||
| Treatment | 373 | ||
| Zoster-associated pain (postherpetic neuralgia) | 373 | ||
| Immunosuppressed patients | 374 | ||
| Diagnosis | 375 | ||
| Histopathology | 375 | ||
| Differential diagnosis | 376 | ||
| Prevention of zoster | 376 | ||
| Inflammatory skin lesions after zoster infection (isotopic response) | 376 | ||
| References | 376 | ||
| Epstein-Barr virus | 377 | ||
| Cytomegalic inclusion disease | 379 | ||
| References | 379 | ||
| Human herpesviruses 6 and 7 | 379 | ||
| Roseola infantum (exanthem subitum, sixth disease) | 380 | ||
| Human herpesvirus 8 | 380 | ||
| References | 380 | ||
| B virus | 381 | ||
| References | 381 | ||
| Infectious hepatitis | 381 | ||
| Hepatitis B virus | 381 | ||
| Hepatitis C virus | 381 | ||
| References | 382 | ||
| Gianotti-Crosti syndrome (papular acrodermatitis of childhood, papulovesicular acrolocated syndrome) | 383 | ||
| References | 383 | ||
| Poxvirus group | 383 | ||
| Variola major (smallpox) | 384 | ||
| References | 384 | ||
| Vaccinia | 384 | ||
| Vaccination | 384 | ||
| Inadvertent inoculation and autoinoculation | 385 | ||
| Generalized vaccinia | 385 | ||
| Eczema vaccinatum | 385 | ||
| Progressive vaccinia (vaccinia necrosum, vaccinia gangrenosum) | 385 | ||
| Cutaneous immunologic complications | 385 | ||
| Benign hypersensitivity reactions to vaccinia | 386 | ||
| Postvaccination follicular eruption | 386 | ||
| Other skin lesions at vaccination scars | 386 | ||
| References | 386 | ||
| Human monkeypox | 386 | ||
| Buffalopoxvirus | 386 | ||
| Zoonotic poxvirus infections | 386 | ||
| Cowpox | 386 | ||
| Farmyard pox | 387 | ||
| Bovine-associated parapoxvirus infections: milker’s nodules, bovine papular stomatitis (BPSV), and pseudocowpox (PCPV) | 387 | ||
| Orf | 387 | ||
| Clinical features | 387 | ||
| Histologic features | 387 | ||
| Human tanapox | 388 | ||
| References | 388 | ||
| Molluscum contagiosum | 388 | ||
| References | 390 | ||
| Picornavirus group | 390 | ||
| Enterovirus infections | 391 | ||
| Herpangina | 391 | ||
| Hand-foot-and-mouth disease | 391 | ||
| Eruptive pseudoangiomatosis | 392 | ||
| References | 392 | ||
| Filovirus | 392 | ||
| References | 393 | ||
| Paramyxovirus group | 393 | ||
| Measles | 393 | ||
| Rubella | 394 | ||
| Congenital rubella syndrome | 394 | ||
| References | 394 | ||
| Asymmetric periflexural exanthem of childhood (APEC) | 395 | ||
| References | 395 | ||
| Parvovirus group | 395 | ||
| Erythema infectiosum (fifth disease) | 395 | ||
| Papular-purpuric gloves-and-socks syndrome | 396 | ||
| Other skin findings attributed to parvovirus B19 | 396 | ||
| References | 396 | ||
| Arbovirus group (Togaviridae) | 397 | ||
| West Nile fever | 397 | ||
| Sandfly fever | 397 | ||
| Dengue | 397 | ||
| Alphavirus | 398 | ||
| Sindbis virus | 398 | ||
| Chikungunya virus | 398 | ||
| References | 398 | ||
| Papovavirus group | 399 | ||
| Warts (verruca) | 399 | ||
| Verruca vulgaris | 399 | ||
| Pigmented warts | 400 | ||
| Flat warts (verruca plana) | 400 | ||
| Plantar warts (verruca plantaris) | 401 | ||
| Histologic features | 401 | ||
| Treatment | 401 | ||
| Flat warts | 401 | ||
| Common warts | 402 | ||
| Plantar warts | 403 | ||
| Genital warts (external genital warts) | 403 | ||
| Condylomata acuminata | 404 | ||
| Bowenoid papulosis and HPV-induced genital dysplasias | 405 | ||
| Giant condyloma acuminatum (Buschke-Lowenstein tumor) | 405 | ||
| Diagnosis | 405 | ||
| Treatment | 406 | ||
| Human papillomavirus vaccination | 407 | ||
| Genital warts in children | 407 | ||
| Recurrent respiratory (laryngeal) papillomatosis | 407 | ||
| Heck’s disease | 408 | ||
| Epidermodysplasia verruciformis | 408 | ||
| Immunosuppressed patients | 409 | ||
| References | 409 | ||
| Trichodysplasia spinulosa | 411 | ||
| References | 411 | ||
| Retroviruses | 412 | ||
| Human T-lymphotropic virus 1 | 412 | ||
| References | 412 | ||
| Human immunodeficiency virus | 413 | ||
| Primary HIV infection (acute seroconversion syndrome) | 414 | ||
| HIV-associated pruritus | 414 | ||
| HIV-associated neoplasia | 415 | ||
| AIDS and Kaposi sarcoma | 416 | ||
| References | 416 | ||
| 20 Parasitic Infestations, Stings, and Bites | 418 | ||
| Phylum Protozoa | 418 | ||
| Class sarcodina | 418 | ||
| Amebiasis cutis | 418 | ||
| Other amebas | 418 | ||
| Class mastigophora | 419 | ||
| Trichomoniasis | 419 | ||
| Leishmaniasis | 419 | ||
| Cutaneous leishmaniasis | 419 | ||
| Clinical features | 419 | ||
| Etiologic factors | 420 | ||
| Epidemiology | 421 | ||
| Pathogenesis | 421 | ||
| Histopathology | 421 | ||
| Diagnosis | 421 | ||
| Treatment | 421 | ||
| Mucocutaneous leishmaniasis (leishmaniasis americana, espundia) | 421 | ||
| Clinical features | 421 | ||
| Etiologic factors | 422 | ||
| Epidemiology | 422 | ||
| Histopathology | 422 | ||
| Laboratory findings | 422 | ||
| Prophylaxis | 422 | ||
| Treatment | 422 | ||
| Visceral leishmaniasis (kala-azar, dumdum fever) | 422 | ||
| Clinical features | 422 | ||
| Etiologic factors | 423 | ||
| Epidemiology | 423 | ||
| Diagnosis | 423 | ||
| Treatment | 423 | ||
| Post–kala-azar dermal leishmaniasis | 423 | ||
| Viscerotropic leishmaniasis | 423 | ||
| Human trypanosomiasis | 423 | ||
| Class sporozoa | 424 | ||
| Toxoplasmosis | 424 | ||
| Phylum Cnidaria | 425 | ||
| Portuguese man-of-war dermatitis | 425 | ||
| Jellyfish dermatitis | 425 | ||
| Hydroid, sea anemone, and coral dermatitis | 426 | ||
| Treatment of stings and cuts | 426 | ||
| Sponges and bristleworms | 426 | ||
| Sea urchin injuries | 427 | ||
| Seaweed dermatitis | 427 | ||
| Dogger Bank itch | 427 | ||
| Phylum Platyhelminthes | 427 | ||
| Class trematoda | 427 | ||
| Schistosome cercarial dermatitis | 427 | ||
| Visceral schistosomiasis (bilharziasis) | 428 | ||
| Cysticercosis cutis | 428 | ||
| Sparganosis | 428 | ||
| Echinococcosis | 429 | ||
| Phylum Annelida | 429 | ||
| Leeches | 429 | ||
| Phylum Nemathelminthes | 429 | ||
| Class nematoda | 429 | ||
| Enterobiasis (pinworm infection, seatworm infection, oxyuriasis) | 429 | ||
| Hookworm disease (ground itch, uncinariasis, ancylostomiasis, necatoriasis) | 430 | ||
| Nematode dermatitis | 430 | ||
| Creeping eruption (larva migrans) | 430 | ||
| Gnathostomiasis | 431 | ||
| Larva currens | 431 | ||
| Dracunculiasis (Guinea worm disease, dracontiasis, Medina worm) | 431 | ||
| Filariasis | 432 | ||
| Elephantiasis tropica (elephantiasis arabum) | 432 | ||
| Loiasis (Loa loa, Calabar swelling, tropical swelling, fugitive swelling) | 433 | ||
| Onchocerciasis | 433 | ||
| Trichinosis | 435 | ||
| Pneumocystosis | 435 | ||
| Phylum Arthropoda | 435 | ||
| Prevention of arthropod-related disease | 435 | ||
| Prevention of disease from ticks and chiggers | 436 | ||
| Prevention of flea-borne illness | 436 | ||
| Class myriapoda | 436 | ||
| Centipede bites (Chilopoda) | 436 | ||
| Millipede burns (Diplopoda) | 437 | ||
| Class insecta | 437 | ||
| Order Lepidoptera | 437 | ||
| Caterpillar dermatitis | 437 | ||
| Moth dermatitis | 438 | ||
| Order Hemiptera | 438 | ||
| Cimicosis (bedbug bites) | 438 | ||
| Reduviid bites | 439 | ||
| Order Anoplura | 439 | ||
| Pediculosis | 439 | ||
| Pediculosis capitis | 440 | ||
| Pediculosis corporis | 440 | ||
| Pediculosis pubis (crabs) | 440 | ||
| Order Diptera | 441 | ||
| Mosquito bites | 441 | ||
| Ked itch | 441 | ||
| Myiasis | 441 | ||
| Order Coleoptera | 442 | ||
| Blister beetle dermatitis | 442 | ||
| Other beetles | 442 | ||
| Order Hymenoptera | 443 | ||
| Bees and wasps | 443 | ||
| Ants | 443 | ||
| Order Siphonaptera | 443 | ||
| Pulicosis (flea bites) | 443 | ||
| Vectors of disease | 444 | ||
| Tungiasis | 444 | ||
| Class arachnida | 444 | ||
| Order Acarina | 444 | ||
| Tick bite | 444 | ||
| Tick paralysis | 445 | ||
| Mites | 445 | ||
| Scabies | 445 | ||
| Animal scabies | 447 | ||
| Other mite diseases | 447 | ||
| Demodex mites | 447 | ||
| Cheyletiella dermatitis | 447 | ||
| Chigger bite | 447 | ||
| Gamasoidosis | 448 | ||
| Grocer’s itch | 448 | ||
| Grain itch | 448 | ||
| Other mite-related dermatitides | 448 | ||
| Order Scorpionidae | 448 | ||
| Scorpion sting | 448 | ||
| Order Arachnidae | 449 | ||
| Arachnidism | 449 | ||
| Latrodectism | 449 | ||
| Loxoscelism | 449 | ||
| Treatment | 449 | ||
| Funnel web spiders | 450 | ||
| Tarantulas (lycosidae: theraphosidae) | 450 | ||
| Phylum Chordata | 450 | ||
| Stingray injury | 450 | ||
| Snakebite | 450 | ||
| Lizard bite | 450 | ||
| 21 Chronic Blistering Dermatoses | 451 | ||
| Pemphigus vulgaris | 451 | ||
| Clinical features | 451 | ||
| Epidemiology | 451 | ||
| Etiologic factors | 452 | ||
| Histopathology | 453 | ||
| Treatment | 453 | ||
| Topical treatment | 453 | ||
| Systemic therapy | 453 | ||
| Pemphigus vegetans | 454 | ||
| References | 454 | ||
| Pemphigus foliaceus | 454 | ||
| Treatment | 455 | ||
| Endemic pemphigus (fogo selvagem) | 455 | ||
| Pemphigus erythematosus (Senear-Usher syndrome) | 456 | ||
| References | 456 | ||
| Paraneoplastic pemphigus | 456 | ||
| References | 457 | ||
| Intraepidermal neutrophilic IgA dermatosis | 457 | ||
| References | 458 | ||
| Bullous pemphigoid | 458 | ||
| Clinical features | 458 | ||
| Etiologic factors | 459 | ||
| Histopathology | 459 | ||
| Treatment | 459 | ||
| Course and prognosis | 460 | ||
| References | 460 | ||
| Pemphigoid gestationis (herpes gestationis) | 460 | ||
| Clinical features | 460 | ||
| Etiologic factors | 461 | ||
| Pathogenesis | 461 | ||
| Histopathology | 461 | ||
| Differential diagnosis | 461 | ||
| Treatment | 461 | ||
| Other pregnancy-related dermatoses | 461 | ||
| Intrahepatic cholestasis of pregnancy (prurigo gravidarum) | 461 | ||
| Polymorphic eruption of pregnancy | 462 | ||
| Pruritic urticarial papules and plaques of pregnancy | 462 | ||
| Papular dermatitis of pregnancy | 462 | ||
| Prurigo gestationis (Besnier) | 462 | ||
| Pruritic folliculitis of pregnancy | 462 | ||
| Linear IgM dermatosis of pregnancy | 462 | ||
| Impetigo herpetiformis | 462 | ||
| References | 462 | ||
| Cicatricial pemphigoid (benign mucosal pemphigoid) | 463 | ||
| Clinical features | 463 | ||
| Etiologic factors | 463 | ||
| Histopathology | 464 | ||
| Treatment | 464 | ||
| References | 464 | ||
| Epidermolysis bullosa acquisita | 464 | ||
| Treatment | 465 | ||
| References | 465 | ||
| Dermatitis herpetiformis (Duhring disease) | 466 | ||
| Clinical features | 466 | ||
| Associated disease | 466 | ||
| Enteropathy | 466 | ||
| Diagnosis | 466 | ||
| Autoantibodies | 466 | ||
| Epidemiology | 466 | ||
| Histopathology | 466 | ||
| Treatment | 467 | ||
| Gluten-free diet | 467 | ||
| References | 467 | ||
| Linear IgA bullous dermatosis | 468 | ||
| Adult linear IgA disease | 468 | ||
| Childhood linear IgA disease (chronic bullous disease of childhood) | 468 | ||
| 22 Nutritional Diseases | 471 | ||
| Vitamin A | 471 | ||
| Hypovitaminosis A (phrynoderma) | 471 | ||
| Hypervitaminosis A | 472 | ||
| 23 Diseases of Subcutaneous Fat | 480 | ||
| Septal panniculitis (acute and chronic erythema nodosum) | 480 | ||
| Lobular Panniculitis | 482 | ||
| Vessel-based lobular panniculitis | 482 | ||
| Nodular vasculitis and erythema induratum | 482 | ||
| Lipodermatosclerosis | 482 | ||
| Physical panniculitis | 483 | ||
| Sclerema neonatorum | 484 | ||
| Subcutaneous fat necrosis of the newborn | 484 | ||
| Cold panniculitis | 484 | ||
| Poststeroid panniculitis | 485 | ||
| Traumatic panniculitis | 485 | ||
| Factitial panniculitis | 485 | ||
| Sclerosing lipogranuloma | 486 | ||
| Enzyme-Related Panniculitis | 486 | ||
| Pancreatic panniculitis (subcutaneous fat necrosis) | 486 | ||
| Alpha-1-antitrypsin deficiency panniculitis | 487 | ||
| Cytophagic histiocytic panniculitis | 487 | ||
| Miscellaneous Forms of Panniculitis | 487 | ||
| Gouty panniculitis | 487 | ||
| Lipodystrophy (lipoatrophy) | 488 | ||
| Congenital lipodystrophies | 488 | ||
| Congenital generalized lipodystrophy | 488 | ||
| Familial partial lipodystrophy | 488 | ||
| Acquired lipodystrophy | 489 | ||
| Acquired partial lipodystrophy (Barraquer-Simons syndrome) | 489 | ||
| Acquired generalized lipodystrophy | 489 | ||
| Centrifugal abdominal lipodystrophy | 490 | ||
| Lipoatrophia annularis (Ferreira-Marques syndrome) | 490 | ||
| Localized lipodystrophy | 490 | ||
| 24 Endocrine Diseases | 491 | ||
| Acromegaly | 491 | ||
| 25 Abnormalities of Dermal Fibrous and Elastic Tissue | 500 | ||
| Collagen | 500 | ||
| 26 Errors in Metabolism | 509 | ||
| Amyloidosis | 509 | ||
| Systemic amyloidoses | 509 | ||
| Primary systemic amyloidosis (AL amyloidosis) | 509 | ||
| Secondary systemic amyloidosis (AA amyloidosis) | 510 | ||
| Dialysis-associated amyloidosis (β2-microglobulin amyloidosis) | 511 | ||
| Senile systemic amyloidosis | 511 | ||
| Cutaneous amyloidosis | 511 | ||
| Primary localized cutaneous amyloidosis | 511 | ||
| Macular amyloidosis | 511 | ||
| Lichen amyloidosis | 511 | ||
| Treatment | 512 | ||
| Nodular amyloidosis | 512 | ||
| Secondary cutaneous amyloidosis | 512 | ||
| Hereditary cutaneous amyloidosis syndromes | 512 | ||
| Pharmaceutical amyloidosis | 513 | ||
| Familial syndromes associated with amyloidosis (heredofamilial amyloidosis) | 513 | ||
| Porphyrias | 514 | ||
| Porphyria cutanea tarda | 515 | ||
| Pseudoporphyria | 517 | ||
| Hepatoerythropoietic porphyria | 517 | ||
| Variegate porphyria | 517 | ||
| Hereditary coproporphyria | 517 | ||
| Erythropoietic protoporphyria | 518 | ||
| X-linked dominant protoporphyria | 519 | ||
| Congenital erythropoietic porphyria | 519 | ||
| Acute intermittent porphyria | 519 | ||
| Transient erythroporphyria of infancy (purpuric phototherapy-induced eruption) | 520 | ||
| Calcinosis Cutis | 521 | ||
| Dystrophic calcinosis cutis | 521 | ||
| Metastatic calcinosis cutis | 522 | ||
| Iatrogenic and traumatic calcinosis cutis | 522 | ||
| Idiopathic calcinosis cutis | 522 | ||
| Idiopathic scrotal calcinosis | 522 | ||
| Subepidermal calcified nodule and milia-like idiopathic calcinosis cutis | 523 | ||
| Tumoral calcinosis | 523 | ||
| Osteoma cutis | 523 | ||
| Lipid Disturbances | 525 | ||
| Xanthomas | 525 | ||
| Xanthoma tuberosum | 525 | ||
| Xanthoma tendinosum | 525 | ||
| Eruptive xanthoma | 525 | ||
| Xanthoma planum (plane xanthoma) | 526 | ||
| Palmar xanthomas | 526 | ||
| Xanthelasma palpebrarum (xanthelasma) | 526 | ||
| Primary hyperlipoproteinemias | 527 | ||
| Lipoprotein lipase deficiency | 527 | ||
| Familial apoprotein CII deficiency | 527 | ||
| Familial hypertriglyceridemia | 527 | ||
| Familial hypercholesterolemia | 527 | ||
| Secondary hyperlipoproteinemia | 528 | ||
| Obstructive liver disease (xanthomatous biliary cirrhosis) | 528 | ||
| Pancreatitis | 528 | ||
| Medication-induced hyperlipoproteinemia | 528 | ||
| Cerebrotendinous xanthomatosis | 528 | ||
| Sitosterolemia (phytosterolemia) | 528 | ||
| Verruciform xanthoma | 529 | ||
| Familial α-lipoprotein deficiency (hypoalphalipoproteinemia, Tangier disease) | 529 | ||
| Niemann-Pick disease | 530 | ||
| Gaucher’s disease | 530 | ||
| Lipoid proteinosis | 531 | ||
| Angiokeratoma corporis diffusum (Fabry disease) | 532 | ||
| Fucosidosis | 533 | ||
| Sialidosis | 533 | ||
| β-Mannosidase deficiency | 533 | ||
| Skin Disorders in Diabetes Mellitus | 533 | ||
| Necrobiosis lipoidica/necrobiosis lipoidica diabeticorum | 533 | ||
| Other diabetic dermadromes | 534 | ||
| Diabetic dermopathy (shin spots) | 534 | ||
| Diabetic bullae | 534 | ||
| Carotenosis | 535 | ||
| Limited joint mobility and waxy skin | 535 | ||
| Other associated conditions in patients with diabetes | 535 | ||
| Other Metabolic Disorders | 535 | ||
| Citrullinemia | 535 | ||
| Hartnup disease | 536 | ||
| Prolidase deficiency | 536 | ||
| Phenylketonuria | 536 | ||
| Alkaptonuria and ochronosis | 537 | ||
| Exogenous ochronosis | 537 | ||
| Wilson’s disease (hepatolenticular degeneration) | 538 | ||
| Tyrosinemia II (Richner-Hanhart syndrome) | 538 | ||
| Hurler syndrome (mucopolysaccharidosis I) | 538 | ||
| Hunter syndrome (mucopolysaccharidosis II) | 539 | ||
| Lafora’s disease | 539 | ||
| CADASIL syndrome | 540 | ||
| Farber disease | 540 | ||
| Adrenoleukodystrophy (Schilder’s disease) | 540 | ||
| Gout | 540 | ||
| Lesch-Nyhan syndrome | 541 | ||
| 27 Genodermatoses and Congenital Anomalies | 542 | ||
| X-Linked, Mosaic, and Related Disorders | 542 | ||
| Incontinentia pigmenti | 542 | ||
| Naegeli-Franceschetti-Jadassohn syndrome | 543 | ||
| Incontinentia pigmenti achromians (hypomelanosis of Ito) | 544 | ||
| Linear and whorled nevoid hypermelanosis | 544 | ||
| Chondrodysplasia punctata | 544 | ||
| Klinefelter syndrome | 545 | ||
| XXYY genotype | 545 | ||
| Turner syndrome | 545 | ||
| Noonan syndrome | 545 | ||
| Multiple lentigines (LEOPARD) syndrome | 546 | ||
| Costello syndrome | 546 | ||
| Cardiofaciocutaneous syndrome | 546 | ||
| Epidermal nevus syndromes | 546 | ||
| Phakomatoses | 547 | ||
| Tuberous sclerosis (epiloia, Bourneville disease) | 547 | ||
| Diagnosis | 548 | ||
| Treatment | 548 | ||
| Neurofibromatosis (von Recklinghausen’s disease) | 548 | ||
| Diagnosis | 550 | ||
| Screening and monitoring for complications | 550 | ||
| Proteus syndrome | 551 | ||
| Von Hippel–Lindau syndrome | 551 | ||
| Ataxia-telangiectasia | 551 | ||
| Epidermolysis bullosa | 552 | ||
| Intraepidermal forms | 552 | ||
| Epidermolysis bullosa simplex, generalized intermediate | 552 | ||
| Localized epidermolysis bullosa simplex | 553 | ||
| Epidermolysis bullosa simplex, generalized severe | 553 | ||
| Epidermolysis bullosa simplex (Ogna) | 553 | ||
| Epidermolysis bullosa simplex with mottled pigmentation | 553 | ||
| Epidermolysis bullosa simplex with muscular dystrophy | 553 | ||
| Junctional forms | 553 | ||
| Junctional epidermolysis bullosa, generalized severe | 553 | ||
| Junctional epidermolysis bullosa with pyloric atresia | 554 | ||
| Dermolytic or dystrophic forms | 554 | ||
| Dominant dystrophic epidermolysis bullosa | 554 | ||
| Bart syndrome | 554 | ||
| Transient bullous dermolysis of the newborn | 555 | ||
| Acrokeratotic poikiloderma (Kindler syndrome, Weary-Kindler syndrome) | 555 | ||
| Ectodermal dysplasia/skin fragility syndrome (McGrath syndrome) | 555 | ||
| Recessive dystrophic epidermolysis bullosa, generalized severe | 555 | ||
| Familial benign chronic pemphigus (Hailey-Hailey disease) | 556 | ||
| Disorders of cornification (ichthyoses and ichthyosiform syndromes) | 556 | ||
| Treatment | 556 | ||
| Ichthyosis vulgaris | 557 | ||
| X-linked ichthyosis | 557 | ||
| Multiple sulfatase deficiency | 557 | ||
| Autosomal recessive ichthyosis | 557 | ||
| Lamellar ichthyosis | 557 | ||
| Nonbullous congenital ichthyosiform erythroderma | 558 | ||
| Harlequin fetus | 558 | ||
| Epidermolytic ichthyosis | 558 | ||
| Ichthyosis bullosa of Siemens | 559 | ||
| Acquired ichthyosis | 559 | ||
| Restrictive dermopathy | 559 | ||
| Ichthyosis linearis circumflexa | 560 | ||
| Neutral lipid storage disease | 560 | ||
| Ichthyosis follicularis (ichthyosis follicularis, alopecia, and photophobia syndrome) | 560 | ||
| Sjögren-Larsson syndrome | 560 | ||
| Refsum syndrome | 560 | ||
| Rud syndrome | 561 | ||
| Keratitis-ichthyosis-deafness syndrome | 561 | ||
| CHILD syndrome: congenital hemidysplasia with ichthyosiform erythroderma and limb defects | 561 | ||
| Erythrokeratodermia variabilis | 562 | ||
| Progressive symmetric erythrokeratodermia | 562 | ||
| Pityriasis rotunda | 562 | ||
| Porokeratosis | 563 | ||
| Plaque-type porokeratosis (Mibelli) | 563 | ||
| Disseminated superficial actinic porokeratosis | 563 | ||
| Linear porokeratosis | 564 | ||
| Porokeratosis palmaris, plantaris, et disseminata | 564 | ||
| Porokeratotic eccrine ostial and dermal duct nevus | 564 | ||
| Darier’s disease (keratosis follicularis, Darier-White disease) | 564 | ||
| Histology | 565 | ||
| Treatment | 565 | ||
| Acrokeratosis verruciformis | 565 | ||
| Pachyonychia congenita | 566 | ||
| Dyskeratosis congenita (Zinsser-Cole-Engman syndrome) | 566 | ||
| Fanconi syndrome | 567 | ||
| Ectodermal dysplasia | 567 | ||
| Hypohidrotic ectodermal dysplasia (anhidrotic ectodermal dysplasia, Christ-Siemens-Touraine syndrome) | 567 | ||
| Hidrotic ectodermal dysplasia | 568 | ||
| AEC syndrome (Hay-Wells syndrome) | 568 | ||
| EEC syndrome | 568 | ||
| Rapp-Hodgkin ectodermal dysplasia syndrome | 568 | ||
| Ectodermal dysplasia with corkscrew hairs | 568 | ||
| Odonto-tricho-ungual-digital-palmar syndrome | 569 | ||
| Lenz-Majewski syndrome | 569 | ||
| CHIME syndrome | 569 | ||
| Lelis syndrome | 569 | ||
| Nectinopathies | 569 | ||
| Pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy, Touraine-Solente-Gole syndrome) | 569 | ||
| Cutis verticis gyrata | 570 | ||
| Aplasia cutis congenita | 570 | ||
| Adams-Oliver syndrome | 570 | ||
| Focal dermal hypoplasia (Goltz syndrome) | 570 | ||
| Werner syndrome (adult progeria) | 571 | ||
| Progeria (Hutchinson-Gilford syndrome) | 571 | ||
| Xeroderma pigmentosum | 572 | ||
| Cockayne syndrome | 572 | ||
| Xeroderma pigmentosum/Cockayne syndrome complex | 572 | ||
| Trichothiodystrophy | 573 | ||
| Bloom syndrome (Bloom-Torre-Machacek syndrome) | 573 | ||
| Rothmund-Thomson syndrome (poikiloderma congenitale) | 573 | ||
| Hereditary sclerosing poikiloderma and mandibuloacral dysplasia | 574 | ||
| Scleroatrophic syndrome of Huriez | 574 | ||
| Franceschetti-Klein syndrome (mandibulofacial dysostosis) | 574 | ||
| Treacher Collins syndrome | 574 | ||
| Oculoauriculofrontonasal syndrome | 574 | ||
| Popliteal pterygium syndrome | 574 | ||
| Van der Woude syndrome | 575 | ||
| Apert syndrome (acrocephalosyndactyly) | 575 | ||
| Pfeiffer syndrome | 575 | ||
| Crouzon syndrome | 575 | ||
| Carpenter syndrome | 575 | ||
| Whistling face syndrome | 575 | ||
| Other syndromes that include hair abnormalities | 575 | ||
| Hallerman-Streiff syndrome | 575 | ||
| Polyostotic fibrous dysplasia (Albright’s disease) | 575 | ||
| Cronkhite-Canada syndrome | 575 | ||
| Marinesco-Sjögren syndrome | 575 | ||
| Generalized trichoepitheliomas | 576 | ||
| Crow-Fukase (POEMS) syndrome | 576 | ||
| Cartilage-hair hypoplasia (McKusick-type metaphyseal chondrodysplasia) | 576 | ||
| Trichorhinophalangeal syndrome | 576 | ||
| Papillon-Lefèvre syndrome | 576 | ||
| Klippel-Feil syndrome | 576 | ||
| McKusick syndrome | 576 | ||
| Atrichia with papules | 576 | ||
| Keratosis pilaris | 577 | ||
| Erythromelanosis follicularis faciei et colli | 577 | ||
| Follicular atrophoderma | 577 | ||
| Keratosis pilaris atrophicans | 577 | ||
| Keratosis pilaris atrophicans faciei and ulerythema ophryogenes | 577 | ||
| Atrophodermia vermiculata | 577 | ||
| Rombo syndrome | 578 | ||
| Keratosis follicularis spinulosa decalvans (Siemens-1 syndrome) | 578 | ||
| H syndrome | 578 | ||
| MELAS syndrome | 578 | ||
| 28 Dermal and Subcutaneous Tumors | 579 | ||
| Cutaneous vascular anomalies | 579 | ||
| 29 Epidermal Nevi, Neoplasms, and Cysts | 625 | ||
| Epidermal nevi | 625 | ||
| Keratinocytic epidermal nevi | 625 | ||
| References | 626 | ||
| Nevus comedonicus | 626 | ||
| References | 627 | ||
| Epidermal nevus syndrome | 627 | ||
| Reference | 627 | ||
| Inflammatory linear verrucous epidermal nevus | 628 | ||
| 30 Melanocytic Nevi and Neoplasms | 680 | ||
| Epidermal melanocytic lesions | 680 | ||
| Ephelis | 680 | ||
| Nevus spilus | 680 | ||
| References | 680 | ||
| Lentigo | 680 | ||
| Lentigo simplex | 680 | ||
| Solar lentigo (lentigo senilis) | 681 | ||
| PUVA lentigines | 681 | ||
| Ink spot lentigo (sunburn lentigo) | 681 | ||
| Labial, penile, and vulvar melanosis (melanotic macules, mucosal lentigines) | 681 | ||
| Multiple lentigines syndrome | 681 | ||
| Moynahan syndrome | 682 | ||
| Generalized lentiginosis | 682 | ||
| Centrofacial lentiginosis | 682 | ||
| Carney complex | 682 | ||
| Inherited patterned lentiginosis in black persons | 682 | ||
| Partial unilateral lentiginosis | 682 | ||
| Peutz-Jeghers syndrome | 682 | ||
| 31 Macrophage/Monocyte Disorders | 699 | ||
| Palisaded granulomatous dermatoses | 699 | ||
| Granuloma annulare | 699 | ||
| Localized granuloma annulare | 699 | ||
| Generalized granuloma annulare | 699 | ||
| Patch-type or macular granuloma annulare | 699 | ||
| Subcutaneous granuloma annulare (deep granuloma annulare, pseudorheumatoid nodule) | 699 | ||
| Perforating granuloma annulare | 700 | ||
| Palmar granuloma annulare/acute-onset painful acral granuloma annulare | 700 | ||
| Granuloma annulare in HIV disease | 701 | ||
| Granuloma annulare and malignant neoplasms | 701 | ||
| Other conditions associated with granuloma annulare | 701 | ||
| Granuloma annulare and eye disease | 701 | ||
| Histology | 701 | ||
| Treatment | 701 | ||
| References | 701 | ||
| Annular elastolytic giant cell granuloma (Meischer’s), annular elastolytic granuloma, and actinic granuloma (O’Brien) | 703 | ||
| 32 Cutaneous Lymphoid Hyperplasia, Cutaneous T-Cell Lymphoma, Other Malignant Lymphomas, and Allied Diseases | 726 | ||
| Cutaneous lymphoid hyperplasia (lymphocytoma cutis, lymphadenosis benigna cutis, pseudolymphoma) | 726 | ||
| Cutaneous lymphoid hyperplasias—nodular B-cell pattern | 726 | ||
| Cutaneous lymphoid hyperplasias—bandlike T-cell pattern | 726 | ||
| Jessner lymphocytic infiltrate of the skin | 727 | ||
| References | 727 | ||
| Cutaneous lymphomas | 727 | ||
| Primary cutaneous T-cell lymphomas | 727 | ||
| Mycosis fungoides | 727 | ||
| Natural history | 728 | ||
| Evaluation and staging | 728 | ||
| Clinical features | 728 | ||
| Alopecia mucinosa | 729 | ||
| Systemic manifestations | 730 | ||
| Pathogenesis | 730 | ||
| Histopathology | 731 | ||
| Differential diagnosis | 731 | ||
| Treatment | 731 | ||
| Topical corticosteroids | 732 | ||
| Topical nitrogen mustard | 732 | ||
| Topical BCNU (carmustine) | 732 | ||
| Ultraviolet therapy | 732 | ||
| Photodynamic therapy | 732 | ||
| Radiation | 732 | ||
| Biologic response modifiers (multimodality immunomodulatory therapy) | 732 | ||
| Retinoids | 733 | ||
| Systemic chemotherapy | 733 | ||
| Fusion toxin | 733 | ||
| References | 733 | ||
| Pagetoid reticulosis | 733 | ||
| Sézary syndrome | 734 | ||
| 33 Diseases of the Skin Appendages | 747 | ||
| Diseases of the hair | 747 | ||
| Noncicatricial alopecia | 747 | ||
| Alopecia areata | 747 | ||
| Clinical features | 747 | ||
| Etiologic factors | 747 | ||
| Histology | 748 | ||
| Differential diagnosis | 748 | ||
| Treatment | 748 | ||
| Prognosis | 749 | ||
| References | 749 | ||
| Telogen effluvium | 749 | ||
| References | 750 | ||
| Anagen effluvium | 750 | ||
| References | 751 | ||
| Pattern alopecia (androgenetic alopecia) | 751 | ||
| Male-pattern baldness | 751 | ||
| Female-pattern alopecia (androgenetic alopecia in women) | 752 | ||
| 34 Disorders of the Mucous Membranes | 789 | ||
| Cheilitis | 789 | ||
| Cheilitis exfoliativa | 789 | ||
| 35 Cutaneous Vascular Diseases | 807 | ||
| Raynaud phenomenon and Raynaud disease | 807 | ||
| Secondary Raynaud phenomenon | 807 | ||
| Raynaud disease (primary Raynaud disease) | 808 | ||
| Treatment | 808 | ||
| Erythromelalgia | 809 | ||
| Red ear syndrome | 810 | ||
| Livedo reticularis, livedo racemosa | 811 | ||
| Cholesterol emboli | 812 | ||
| Evaluation of the patient with possible cutaneous vascular disorders | 813 | ||
| Livedoid vasculopathy | 813 | ||
| Calciphylaxis | 814 | ||
| Marshall-White syndrome and Bier spots | 816 | ||
| Purpura | 816 | ||
| Pathogenesis | 816 | ||
| Evaluation | 816 | ||
| Thrombocytopenic purpura | 816 | ||
| Immune thrombocytopenic purpura (immune thrombocytopenia) | 816 | ||
| Drug-induced thrombocytopenia | 817 | ||
| Thrombotic microangiopathy | 818 | ||
| Thrombotic thrombocytopenic purpura | 818 | ||
| Hemolytic uremic syndrome | 818 | ||
| Nonthrombocytopenic purpura (dysproteinemic purpura) | 819 | ||
| Cryoglobulinemia and cryofibrinogenemia | 819 | ||
| Waldenström hyperglobulinemic purpura (purpura hyperglobulinemica) | 821 | ||
| Waldenström macroglobulinemia | 821 | ||
| Purpura secondary to clotting disorders | 822 | ||
| Drug-induced and food-induced purpura | 822 | ||
| Purpura fulminans | 822 | ||
| Disseminated intravascular coagulation | 824 | ||
| Congenital fibrinogen disorders | 824 | ||
| Blueberry muffin baby | 824 | ||
| Miscellaneous purpuric manifestations | 825 | ||
| Deep venous thrombosis | 825 | ||
| Superficial thrombophlebitis | 825 | ||
| Mondor’s disease | 826 | ||
| Postcardiotomy syndrome | 826 | ||
| Orthostatic purpura (stasis purpura) | 826 | ||
| Obstructive or traumatic purpura | 826 | ||
| Paroxysmal nocturnal hemoglobinuria | 827 | ||
| Paroxysmal hand hematoma (Achenbach syndrome) | 827 | ||
| Easy bruising syndromes | 827 | ||
| Painful bruising syndrome (autoerythrocyte sensitization, Gardner-Diamond syndrome, psychogenic purpura) | 827 | ||
| Pigmentary purpuric eruptions (progressive pigmentary dermatosis, progressive pigmenting purpura, purpura pigmentosa chronica) | 828 | ||
| Purpuric agave dermatitis | 829 | ||
| Vasculitis | 829 | ||
| Classification | 829 | ||
| Small-vessel vasculitis | 830 | ||
| Cutaneous small-vessel vasculitis (cutaneous leukocytoclastic vasculitis) | 830 | ||
| Histology | 830 | ||
| Pathogenesis | 830 | ||
| Etiology | 831 | ||
| Clinical evaluation | 831 | ||
| Treatment | 831 | ||
| Cutaneous vasculitis and connective tissue disease | 831 | ||
| Subtypes of small-vessel vasculitis | 832 | ||
| IgA vasculitis (Henoch-Schönlein purpura) | 832 | ||
| Acute hemorrhagic edema of infancy | 833 | ||
| Urticarial vasculitis | 833 | ||
| Cryoglobulinemic vasculitis | 834 | ||
| Macular lymphocytic arteritis (lymphocytic thrombophilic arteritis) | 835 | ||
| Golfer’s and exercise-related “vasculitis” | 835 | ||
| Erythema elevatum diutinum | 835 | ||
| Granuloma faciale | 836 | ||
| Polyarteritis nodosa | 837 | ||
| Treatment | 838 | ||
| Cutaneous polyarteritis nodosa | 838 | ||
| ANCA-positive vasculitides | 838 | ||
| Microscopic polyangiitis | 839 | ||
| Granulomatosis with polyangiitis (Wegener’s granulomatosis) | 839 | ||
| Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) | 840 | ||
| Cocaine-associated vasculitis and levamisole-induced vasculopathy/vasculitis | 841 | ||
| Giant cell arteritis/temporal arteritis | 842 | ||
| Takayasu arteritis | 843 | ||
| Malignant atrophic papulosis | 843 | ||
| Thromboangiitis obliterans (Buerger’s disease) | 844 | ||
| Arteriosclerosis obliterans | 845 | ||
| Diffuse dermal angiomatosis | 845 | ||
| Mucocutaneous lymph node syndrome (Kawasaki disease) | 846 | ||
| Pathogenesis | 846 | ||
| Treatment | 847 | ||
| Telangiectasia | 847 | ||
| Generalized essential telangiectasia | 847 | ||
| Unilateral nevoid telangiectasia | 848 | ||
| Hereditary hemorrhagic telangiectasia (Osler’s disease) | 848 | ||
| Leg ulcers | 850 | ||
| Venous diseases of the extremities | 850 | ||
| Stasis dermatitis | 850 | ||
| Venous insufficiency and obesity-associated mucinosis | 850 | ||
| Venous insufficiency ulceration | 850 | ||
| Arterial insufficiency (ischemic) ulcer | 851 | ||
| Neuropathic ulcers | 852 | ||
| Lymphedema | 852 | ||
| Types | 852 | ||
| Lymphedema praecox | 852 | ||
| Nonne-Milroy-Meige syndrome (hereditary lymphedema) | 853 | ||
| Lymphedema-distichiasis syndrome | 853 | ||
| Emberger syndrome | 853 | ||
| WILD syndrome (warts, immunodeficiency, lymphedema, anogenital dysplasia) | 854 | ||
| Hypotrichosis-telangiectasia- lymphedema syndrome | 854 | ||
| Primary lymphedema associated with yellow nails and pleural effusion (yellow nail syndrome) | 854 | ||
| Secondary lymphedema | 854 | ||
| Postmastectomy lymphangiosarcoma (Stewart-Treves syndrome) | 854 | ||
| Obesity-related lymphedema | 854 | ||
| Postinflammatory lymphedema | 854 | ||
| Bullous lymphedema | 854 | ||
| Factitial lymphedema | 854 | ||
| Podoconiosis | 854 | ||
| Occupational hand edema | 855 | ||
| Evaluation | 855 | ||
| Treatment | 855 | ||
| 36 Disturbances of Pigmentation | 856 | ||
| Pigmentary demarcation lines | 856 | ||
| References | 856 | ||
| Abnormal pigmentation | 857 | ||
| Hemosiderin hyperpigmentation | 857 | ||
| Postinflammatory hyperpigmentation (postinflammatory pigmentary alteration) | 857 | ||
| References | 857 | ||
| Melasma (chloasma) | 858 | ||
| References | 858 | ||
| Reticulate pigment disorders of the skin | 859 | ||
| Dyschromatosis symmetrica hereditaria (reticulate acropigmentation of Dohi) | 859 | ||
| 37 Dermatologic Surgery | 874 | ||
| Preparation for surgery | 874 | ||
| Anticoagulants | 874 | ||
| 38 Cutaneous Laser Surgery | 901 | ||
| Laser principles | 901 | ||
| References | 901 | ||
| Laser treatment of vascular lesions | 902 | ||
| Pulsed dye laser | 902 | ||
| Potassium titanyl phosphate laser | 904 | ||
| Long-pulsed infrared lasers | 905 | ||
| Intense pulsed light | 905 | ||
| References | 905 | ||
| Laser treatment for pigmented lesions | 906 | ||
| Epidermal pigmented lesions | 907 | ||
| Dermal pigmented lesions | 907 | ||
| Tattoos | 907 | ||
| Tattoo complications | 908 | ||
| References | 909 | ||
| Laser hair removal | 910 | ||
| References | 910 | ||
| Ablative laser resurfacing | 911 | ||
| Carbon dioxide lasers | 911 | ||
| Erbium:yttrium-aluminum-garnet laser | 911 | ||
| Fractional resurfacing | 912 | ||
| References | 912 | ||
| 39 Cosmetic Dermatology | 913 | ||
| Soft tissue augmentation | 913 | ||
| Bovine collagen | 913 | ||
| Human collagen | 913 | ||
| Hyaluronic acid | 914 | ||
| Poly-L-lactic acid | 914 | ||
| Calcium hydroxylapatite | 915 | ||
| Silicone | 915 | ||
| Polymethylmethacrylate | 915 | ||
| Expanded polytetrafluoroethylene | 915 | ||
| Autologous fat transplantation | 916 | ||
| References | 916 | ||
| Botulinum toxin | 916 | ||
| Glabellar frown lines | 917 | ||
| Horizontal forehead lines | 917 | ||
| Crow’s feet | 917 | ||
| Other locations | 917 | ||
| Hyperhidrosis | 917 | ||
| References | 919 | ||
| Varicose and telangiectatic veins | 919 | ||
| Sclerotherapy | 919 | ||
| Sclerosing solutions | 919 | ||
| Complications | 921 | ||
| Ambulatory phlebectomy | 921 | ||
| Endovenous ablation | 921 | ||
| References | 921 | ||
| Liposuction | 922 | ||
| References | 922 | ||
| Chemical peels | 922 | ||
| Superficial peel | 922 | ||
| Medium-depth peel | 923 | ||
| Deep peel | 923 | ||
| References | 923 | ||
| Index | 925 | ||
| A | 925 | ||
| B | 928 | ||
| C | 930 | ||
| D | 934 | ||
| E | 936 | ||
| F | 938 | ||
| G | 939 | ||
| H | 940 | ||
| I | 943 | ||
| J | 944 | ||
| K | 944 | ||
| L | 945 | ||
| M | 947 | ||
| N | 950 | ||
| O | 951 | ||
| P | 951 | ||
| Q | 956 | ||
| R | 956 | ||
| S | 958 | ||
| T | 961 | ||
| U | 963 | ||
| V | 964 | ||
| W | 965 | ||
| X | 965 | ||
| Y | 965 | ||
| Z | 965 | ||
| Clinical Key ad | IBC1 |