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Photodynamic Therapy with ALA

Photodynamic Therapy with ALA

Hugh Barr | C S Betz | A Curnow | M Fehr | P Hillemanns | R Hornung | J C Kennedy | A Leunig | Z Malik | H Messmann | V Schleyer | W Stummer | R M Szeimies | R Waidelich | Reinhold Baumgartner | Barbara Krammer | Roy Pottier | Herbert Stepp | Donat-P Hader | Giulio Jori

(2007)

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Abstract

Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of diseases. One common strategy used during this light activated process is to induce the accumulation of significant amounts of a photosensitising agent in the diseased tissue. The naturally occurring amino acid 5-aminovulinic acid (ALA) is used to produce high levels of the photosensitizer, Protoprophyin IX, in the therapy known as ALA-PDT. Written by experts in the field Photodynamic therapy with ALA outlines a variety of clinical approaches to the topic, outlining current applications. These include the use of ALA-PDT and ALA-FD (fluorescence diagnosis) in the areas of dermatology, urology, brain, otorhinolaryngology, gynaecology and gastroenterology. Also included is a chapter that comprehensively reviews the scientific principles of ALA-PDT. Primarily aimed a clinical audience Photodynamic therapy with ALA should provide a comprehensive review and useful insight into ALA-PDT.