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Obstetrics: Prepare for the MRCOG

Obstetrics: Prepare for the MRCOG

Philip N Baker | Alec S. McEwan | Sabaratnam Arulkumaran | Shreelata T Datta | Tahir A Mahmood | Fiona Reid | Mahmood I Shafi | Catherine Aiken

(2015)

Additional Information

Book Details

Abstract

Obstetrics is a new e-book presenting a collection of key articles from Obstetrics, Gynaecology and Reproductive Medicine, mapped by module to the MRCOG Part 2 exam.

As well as mapping to the MRCOG, the Inkling version of this e-book also enables anyone with a short-term interest in a specific area to buy individual articles at a price-point which will give affordable access to all readers (from medical students to GPs and practitioners in related areas, such a genitourinary medicine). Inkling’s app-like quality of user experience on mobiles, tablets and laptops will be an added bonus for learning on the move. As well as being vital preparation for the MRCOG exam, this material is also ideal for life-long learning, CPD and, indeed, preparation for all post-graduate exams in obstetrics (not just MRCOG), including especially the new EBCOG exam in Europe and local college exams in India.[the Middle East and Africa.

The parent journal is a rolling, continuously updated review of obstetrics over a three-year cycle covering all the important topics for the MRCOG Part 2 exam. Its Editorial Board comprises some of Europe’s most influential specialists and includes, among others, the current Presidents of FIGO and EBCOG, as well as the past President of the Royal College of Obstetrics and Gynaecology. The journal’s articles are refreshed, updated, augmented or replaced as appropriate each time the subject is due for revision to provide a concise overview of knowledge and practice core to the curriculum. Each article is written by invited experts and overseen by the relevant subject specialist on the Board. There is a trainee on the Board too, ensuring relevance and accessibility to exam candidates.

  • Inkling version gives a highly attractive, app-like user experience, enabling much easier, more pleasurable use of the content on smartphones, tablets and laptops for learning on the move.
  • Affordable chapter-level purchase on Inkling version opens out the journal’s authority and expertise to all interested users (medical students, family clinicians, genitourinary specialists and all other related specialties).
  • Derived from top-notch authoritative content from the OGRM journal.
  • Overseen by a world-class Editorial Board of experts, which includes the Presidents of FIGO, EBCOG and past President of the RCOG.
  • A trainee representative on the Editorial Board ensures relevance and accessibility for exam candidates.
  • Relevant to all post-graduate exams, including the new EBCOG exam and college exams in India, the Middle East and Africa.
  • Highly appropriate content for life-long learning, personal development portfolios and CPD.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Obstetrics: Prepare for the MRCOG Fm-1
Copyright Page Fm-4
Table of Contents Fm-7
Preface Fm-6
About The Obstetrics, Gynaecology and Reproductive Medicine Journal and eBooks Fm-10
Section 1: Fetal 1
Suspected fetal anomalies 1
Introduction 1
Case 1: Diagnosis of maternal type 1 diabetes following diagnosis of fetal structural abnormality at 26 weeks gestation 1
Case 2: Use of free fetal DNA to determine fetal gender in a case of bladder exstrophy 4
Case 3: Diagnosis of an autosomal dominant genetic condition following detection of fetal upper limb abnormalities 5
Summary 7
Further reading 7
Fetal anaemia 8
Introduction 8
Case 1 9
Fetomaternal haemorrhage (FMH) 9
Case 2 10
Rhesus D isoimmunisation 12
Case 3 12
Parvovirus B19 infection 12
Further reading 14
Stillbirth in the UK: current trends, investigation and opportunities for prevention 15
Introduction and trends 15
Aetiology 15
Investigations when a stillbirth occurs 19
Interventions to reduce stillbirth rates 19
Conclusion 21
Further reading 21
Advances in fetal therapy 22
Introduction 22
Pharmacotherapy 22
Fetal and neonatal alloimmune thrombocytopenia 23
Twin–twin transfusion syndrome (TTTS) 23
Radiofrequency ablation 24
Diaphragmatic hernia 24
Meningomyelocoele 25
Lower urinary tract obstruction 25
Genomics and free fetal DNA 25
Gene therapy and fetal stem cells 26
Summary 26
Further reading 26
Fetal infection: a pragmatic approach to recognition and management 28
Introduction 28
Case 1 (parvovirus) 28
Case 2 (cytomegalovirus) 30
Further reading 32
Prenatal diagnosis of single gene disorders 33
Introduction 33
Case example 35
Further Reading 38
Ultrasound in antenatal diagnosis of structural abnormalities 39
Introduction 39
Screening 39
Recommended strategy 40
Consent for ultrasound 40
Cost effectiveness of ultrasound 40
Population to be screened 40
Effectiveness of screening 40
First trimester screening for structural abnormalities 41
Structural abnormalities detectable by antenatal ultrasound 41
The use of 3 and 4 dimensional ultrasound in the detection structural abnormalities 43
Complimentary role of fetal MRI in structural abnormalities 44
Training issues 44
Safety of ultrasound 44
Conclusions 44
Further reading 44
Fetal macrosomia 46
Introduction 46
Risk factors 46
Suspected fetal macrosomia 46
Management 47
Summary 48
Further reading 49
Screening for Down syndrome 50
Introduction 50
Definitions 50
A historical perspective 50
National Screening Policy 51
Further improvements 52
The role of later ultrasound scanning in screening for Down syndrome 53
Non-invasive prenatal diagnosis 54
Consent and quality assurance 54
Further reading 55
From the UK NSC website: 55
Antepartum fetal health 56
Introduction 56
Assessment of risk and surveillance strategies 56
Low-risk pregnancy 56
High-risk pregnancy 57
Conclusion 60
Further reading 60
The diagnostic and therapeutic role of ultrasound in obstetrics 61
Introduction 61
Elective use of ultrasound 61
Reactive use of ultrasound 65
Conclusions 66
Further reading 66
Section 2: Maternal 67
Management of HIV infection in pregnancy 67
HIV and women 67
Natural history 67
Mother-to-child-transmission 67
Antenatal testing 68
Methods of MTCT 68
Stigma and mental health conditions in HIV positive pregnant women 68
Sexually Transmitted Infections (STIs) and pregnant women 69
HAART in pregnancy 69
Amniocentesis, cervical suture and invasive procedures 69
Late booking or women presenting in labour who are untested 70
Mode of delivery (see Table 1) 70
Pre-term delivery 71
Treatment to the newborn 71
Breast feeding in HIV positive women 71
Testing of infants 71
Conclusion 71
Further reading 71
Vaccinations in pregnancy 73
Introduction 73
General principles 73
Vaccinations with specific relevance to pregnancy (Table 2) 74
Vaccinations where indications are unchanged in pregnancy (see Table 2) 77
Travel vaccines 78
Relevant potential future vaccines 78
Conclusion 78
Further reading 78
Renal disease in pregnancy 80
Introduction 80
Renal physiology in normal pregnancy 80
Pregnancy in women with chronic kidney disease 80
Dialysis and pregnancy 84
Kidney transplantation and pregnancy 85
Further reading 86
Connective tissue disorders and dermatological disorders in pregnancy 87
Connective tissue disorders in pregnancy 87
Heritable connective tissue disorders 87
Autoimmune connective tissue disorders 88
Dermatological conditions in pregnancy 91
Dermatological conditions not specific to pregnancy 92
Dermatological conditions specific to pregnancy 94
Further reading 96
Prescribing in pregnancy 97
Introduction 97
1: A framework for prescribing in pregnancy 97
2: Prescribing for common medical conditions in pregnancy 101
3: Prescribing for complex medical conditions in pregnancy 103
Further reading 105
Thyroid disorders and other endocrinological disorders in pregnancy 106
Thyroid physiology 106
Hypothyroidism 106
Hyperthyroidism 107
Vitamin D deficiency in pregnancy 109
Hyperparathyroidism 110
Hypoparathyroidism 110
Pituitary disorders in pregnancy 110
Cushing's syndrome 111
Adrenal disease 112
Conclusion 113
Further reading 113
Cardiovascular disease in pregnancy 115
Introduction 115
Cardiovascular physiology 115
Normal cardiovascular examination 115
Cardiac investigations in pregnancy 116
Pre-pregnancy counselling and contraception 117
Ischaemic heart disease 118
Aortic disease 118
Cardiomyopathy 118
Valvular heart disease 119
Prosthetic heart valves 120
Arrhythmias 120
Pulmonary hypertension 120
Congenital heart disease 121
Obstetric care in cardiac patients at delivery 121
Summary 121
References 121
Further reading 121
Hyperemesis, gastrointestinal and liver disorders in pregnancy 122
Overview 122
Pregnancy related gastrointestinal diseases 122
Pregnancy unrelated gastrointestinal diseases 124
Further reading 126
Advanced maternal age 127
Background 127
Introduction 127
Antenatal risks 127
Intrapartum risks 131
Advantages of later childbearing 131
Conclusion 131
Further reading 132
Abdominal pain in pregnancy: a rational approach to management 133
Case history 133
Rational approach to ‘abdominal pain’ in pregnancy 133
Effect of pregnancy on the diagnosis of underlying pathology 134
Common ‘pathological’ causes of abdominal pain during pregnancy and their management 135
Common obstetric conditions during late pregnancy that may present with ‘acute abdominal pain’ 135
Conditions associated with, but not caused by pregnancy 137
Abdominal pain due to gynaecological conditions 138
Conclusion 140
Further reading 140
Pre-existing type I and type II diabetes in pregnancy 141
Introduction 141
Physiological adaptations during pregnancy 141
Pre-pregnancy counselling 141
Lifestyle modifications 142
Review of medication 142
Management of diabetic complications during pregnancy 142
Diabetic medication during pregnancy 143
Management of pre-existing diabetic complications 144
Antenatal management 144
Conclusions 146
Further reading 146
Gestational diabetes 147
Introduction 147
Epidemiology 147
Pathogenesis 147
Diagnostic criteria 147
Perinatal complications (Box 2) 148
Rationale for treatment 148
Screening 149
Management 150
Acceptability of treatment 151
Obstetric considerations 151
Neonatal care 152
Long-term risks for women 152
Long-term risks for baby 152
Conclusions 152
Further reading 152
Substance misuse in pregnancy 154
Introduction 154
Case 1 (booking) 154
Case 2 (booking) 155
Case 2 (antenatal care) 156
Case 2 (antenatal care) 157
Case 1 (intrapartum care) 157
Case 2 (intrapartum care) 157
Case 1 (post-natal care) 158
Case 2 (post-natal care) 158
Further reading 158
Neurological disease in pregnancy 160
Epilepsy 160
Headache 161
Cerebrovascular disorders 163
Multiple sclerosis 163
Myasthenia gravis 163
Cerebral tumours 164
Myotonic dystrophy 164
Bell's palsy 164
Entrapment neuropathies 164
Further reading 165
Cancer in pregnancy 166
Introduction 166
Investigations and imaging in pregnancy 166
Management 166
Treatment 166
Organ pathology 168
Summary 172
Further reading 172
An obstetrician's guide to perinatal psychiatry 173
Introduction 173
Case 1 173
Epidemiology of mental illnesses in pregnancy and post-partum 173
Obstetrician's role in identification of women who require referral to mental health services 173
Case 2 174
Risk of relapse post-partum 174
Case vignette 3 174
Post-partum psychosis 174
Management of pregnant women with mental illnesses 175
Medication in pregnancy 175
Medication during lactation 176
Other interventions 176
Mental Health Act and Mental Capacity Act 176
Referral to Social Care 176
Case 4 176
Conclusion 177
Further reading 177
Sickle cell disease in pregnancy 178
Introduction 178
Background 178
Definition 178
Pathophysiology 178
Erythrocyte changes 178
Clinical features 179
Impact on maternal and fetal outcome 179
Screening 179
Management 180
Case study 186
Conclusion 186
Further reading 186
Respiratory disease in pregnancy 188
Introduction 188
Asthma 188
Respiratory tract infections 191
Cystic fibrosis 194
Bronchiectasis 194
Pulmonary arterial hypertension 194
Cystic fibrosis lung transplant recipients 195
Restrictive & fibrotic lung diseases 195
Conclusion 195
Further reading 196
Bleeding disorders in pregnancy 197
Introduction 197
Thrombocytopenia in pregnancy 197
Thrombotic microangiopathies 200
Inherited coagulation factor deficiencies 201
Further reading 203
The implications of obesity on pregnancy outcome 205
Miscarriage 205
Gestational diabetes 205
Fetal risks 207
Labour and delivery 207
Further reading 207
Urogynaecological complications in pregnancy: an overview 209
Physiological changes to the urinary tract during pregnancy 209
Urinary tract infection in pregnancy 209
Urolithiasis 210
Urological injury at caesarean section 211
Urinary retention 212
Urological cancer in pregnancy 212
Further reading 212
Venous thromboembolism in pregnancy 214
Introduction 214
The scale of the problem 214
Physiological changes in the coagulation system during pregnancy 214
Risk factors for venous thromboembolism in pregnancy 214
Prevention of venous thromboembolism in pregnancy 215
Conclusion 217
Further reading 217
Section 3: General obstetrics: (antenatal, intrapartum and postnatal) 225
Routine antenatal management at the booking clinic 225
Introduction 225
The first antenatal booking visit 225
Identification of risk factors 225
Antenatal care and education 226
Antenatal care and lifestyle 226
Advice on diet and use of supplements before and during pregnancy 226
Minor ailments of pregnancy 228
Clinical examination 228
Routine (booking) blood tests 229
Screening for haematological disorders 230
Screening for infections 230
Screening for fetal anomalies 231
Further reading 232
Routine antenatal management later in pregnancy 233
Introduction 233
Why provide antenatal care? 233
What pattern of care is effective? 233
Screening for clinical problems 234
BMI should be reassessed in the third trimester in overweight women 238
Maternal request for a Caesarean section 238
Further reading 238
Common symptoms and signs during pregnancy 240
Introduction 240
Physiological adaptations during pregnancy 240
Conclusion 243
Further reading 243
Antenatal management of teenage pregnancy 245
Introduction 245
Teenage Pregnancy Strategy and beyond 245
Risk factors for teenage pregnancy 245
Antenatal care 245
Engaging teenagers in maternity care 249
Conclusion 250
Further reading 250
Therapeutic strategies for the prevention and treatment of pre-eclampsia and intrauterine growth restriction 251
Introduction 251
Case 1. Intrauterine growth restriction – therapies for prevention 251
Intrauterine growth restriction – therapies for treatment 252
Intrauterine growth restriction – potential new strategies for prevention or treatment 253
Case 2. Pre-eclampsia – therapies for prevention 253
Case 3. Pre-eclampsia – therapies for treatment 254
Pre-eclampsia – potential new strategies for prevention or treatment 255
Conclusion 256
Further reading 256
Twin pregnancy 257
Introduction 257
Zygosity and chorionicity 257
First trimester screening 257
Anomaly screening 257
Management of twins discordant for fetal anomaly 258
Abnormalities specific to twins 258
Anomalies confined to monochorionic gestations 259
Twin reversed arterial perfusion sequence (TRAP) 260
Monochorionic, monoamniotic twins 260
Conjoined twins 261
Antenatal management 261
Conclusions 262
Further reading 262
Prolonged pregnancy 263
Definition 263
Incidence 263
Calculation of gestational age 263
Risk factors 263
Aetiology, pathophysiology, and clinical risks 264
Management 264
Planned delivery 265
Expectant management 265
Economic considerations 266
Intrapartum management 266
Conclusion 266
Further reading 266
Antepartum haemorrhage 268
Introduction 268
Case 1 268
Case 2 269
Discussion 270
Antenatal management 270
Imaging evaluation 271
Use of blood and blood components 271
Further reading 272
Current challenges in pregnancy-related mortality 273
Introduction 273
Definitions 273
Measures of maternal mortality 273
Limitations in calculating maternal mortality and cause of death 274
Current estimates of maternal mortality 274
Trends in maternal mortality 274
The aetiologies of maternal mortality 274
Reducing maternal mortality 277
Conclusion 280
Further reading 280
Management of a woman with a previous preterm birth 281
Introduction 281
Case history – part 1 281
Case history – part 2 283
Conclusion 285
Further reading 286
Induction of labour 287
Introduction 287
Physiology of labour 287
Prevention of induction of labour 288
Indications for induction of labour 288
Contraindications to induction of labour 288
Timing of induction of labour 288
Methods of induction of labour 289
Induction of labour in women with previous caesarean sections 291
Monitoring and pain relief associated with induction of labour 292
Conclusion 292
Further reading 292
Management of preterm labour 294
Introduction 294
Incidence of preterm birth 294
Causes of preterm birth 294
Prediction – in the general population and those at increased risk 294
Therapeutic interventions to prevent PTL in those at high risk 295
Diagnosis of PTL 297
Treatment of PTL 297
Further reading 300
Mechanisms and management of normal labour 301
Physiology of normal labour 301
Normal labour 302
Mechanisms of normal labour 303
Other mechanisms 303
Management of labour 304
Assessing maternal well-being 304
Assessing fetal well-being 304
Assessing progress of labour 304
Management of suspected delay in normal labour 304
Pain relief 305
Posture in labour 305
Further reading 305
Prioritization on the labour suite 307
General principles 307
Consultant presence on labour suite 308
Simulation training 308
Prioritizing (triage) the workload 308
Use of resources and managing challenging situations 309
Example of a labour suite board (Table 1) 309
Further reading 311
Intrapartum fetal surveillance 312
Introduction 312
Case 1 312
Patterns of hypoxia resulting in birth injury 313
Case 2 314
Case 3 317
CTG monitoring, medico-legal issues and best practice recommendations 319
Best practice recommendations and risk management issues related to EFM 319
Patient identity 319
Maternal pulsations 319
Poor quality of the trace 320
Misinterpretation of CTGs 320
Inappropriate action with suspicious or pathological CTG 320
Role of adjuvant tests 320
Overall clinical picture and pattern evolution of CTG 320
Diagnosis to decision to deliver interval 321
Teamwork and communicating findings 321
Storage of CTG 321
Training in CTG interpretation 321
Audit and risk management 321
Conclusion 321
Further reading 321
Meconium in labour 323
Introduction 323
Formation and composition of meconium 323
Normal maturation of fetal gastrointestinal tract 323
Grading of meconium 324
Intrapartum management 324
Meconium in the term fetus 324
Meconium in the pre-term fetus 325
Complications of meconium-stained amniotic fluid 325
Meconium aspiration syndrome 325
Infection 327
Prevention of meconium aspiration syndrome 327
Amnioinfusion 327
Induction of labour at 41 weeks 328
Other potential methods 328
Conclusion 328
Further reading 328
Malpositions and malpresentations of the fetal head 329
Introduction 329
Fetal head presentations and positions – definitions and mechanisms of labour 329
Aetiology of malpresentations and malpositions of fetal head 329
Clinical presentation and diagnosis 330
Signs of obstructed labour 331
Obstetric outcomes associated with malpositions or malpresentations of the fetal head 331
Occipitoposterior position (OP) 332
Causes 332
Mechanism of labour 332
Diagnosis 333
Prevention 333
Management 333
Role of ultrasound assessment of the fetal head position at instrumental delivery 334
Occipitotransverse position 334
Face presentation 334