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Electrocardiology '97 - Proceedings Of The Xxiv International Congress On Electrocardiology

Electrocardiology '97 - Proceedings Of The Xxiv International Congress On Electrocardiology

Bacharova Ljuba | Macfarlane Peter W

(1998)

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Book Details

Abstract

This volume provides a comprehensive synthesis of the recent advances in the field of electrocardiology, giving a unified framework for a multidisciplinary approach to further studies in this highly complex field. It should serve as a valuable reference for practising, clinical and investigative cardiologists as well as graduate students.

Table of Contents

Section Title Page Action Price
Preface v
International Society of Electrocardiology vi
Contents vii
I. Basic Electrophysiology and Electropharmacology 1
Heterogeneity in Sensitivity of Cardiac Myocytes to Ischemia as a Substrate for Arrhythmogenesis in Ischemia and Reperfusion 3
1 Introduction 3
2 Material and Methods 4
3 Results 4
4 Conclusion 6
Acknowledgment 6
References 7
The Antiarrhythmic-Defibrillatory Effect of d-Sotalol in Monolayer of Rat Cardio Myocytes 8
Introduction 8
Materials and Methods 9
Results 10
Discussion 10
References 13
Effects of Vesnarinone on the Delayed Rectifier K+ Current - Experimental and Simulation Study - 14
Introduction 14
Methods 15
Results 16
Discussion 17
References 17
A New Model for The Evaluation of Posthypoxic Recovery in Guinea Pig Papillary Muscle 19
Introduction 19
Aims of the Study 20
Methods 20
Summary of the Results 21
Discussion 22
References 22
Delayed Protection of the Heart Against Ischemia and Postischemic Reperfusion (I-R)-Induced Arrhythmias by 7-OXO-Prostacyclin (PGI2): Molecular Mechanisms 23
Introduction 23
Material and Methods 24
Results 24
Discussion 25
Conclusions 26
Acknowledgments 26
References 26
Cooling Effect on Activation Sequence of the Ventricular Epicardium in the Rabbit 27
1 Introduction 27
2 Methods 27
3 Results 28
4 Discussion 30
5 Conclusion 30
Acknowledgements 30
References 30
Alterations of Ventricular Epicardial Repolarization Sequence Under Moderate Heart Cooling in the Rabbit 31
1 Introduction 31
2 Methods 31
3 Results 32
4 Discussion 32
5 Conclusion 34
Acknowledgements 34
References 34
Preconditioning With Norepinephrine in Isolated Guinea Pig Cardiomyocytes 35
Introduction 35
Aims of the study 36
Methods 36
Drugs used 36
Protocols 36
Discussion 38
Acknowledgements 38
References 38
Subcellular Changes in the Heart with Transient or Fatal Ventricular Arrhythmias 39
Introduction 39
Materials and Methods 40
Results 41
Discussion 43
References 44
Acknowledgments 44
II. Computer Modeling 45
Ventricular Activation as a Composition of Deterministic and Stochastic Processes 47
1 Introduction 47
2 Materials and Method 48
3 Results 48
4 Discussion 49
5 Conclusion 50
Acknowledgement 50
References 50
A Simulation Study of Torsade De Pointes With QT Prolongation 51
Introduction 51
Methods 51
Results 53
Discussion 54
References 54
Computer Simulation Study of Vectorcardiographic Manifestations of Heterogeneous Left Ventricular Hypertrophy 55
1 Introduction 55
2 Method 56
3 Results 57
4 Conclusion 58
Acknowledgments 58
References 58
Inverse Localization of Preexcitation Sites Using \"Jumping Dipole 59
1 Introduction 59
2 Method 59
3 Results 60
4 Discussion and Conclusions 62
Acknowledgments 62
References 62
Models for Simplified Mapping of Heart Electrophysiological States 63
Abstract 63
1 Introduction 63
2 Methods 63
2.1 Model of cardioelectric generator for depolarization 63
2.2 Model of cardioelectric generotor for repolarization 64
3 Results and Conclusions 65
References 66
Biophysical Approach to the Comparative Electrocardiology 67
References 70
Forward Solution Based on Experimental Data Measured in Animals with Different Myocardial Activation Patterns 71
1 Introduction 71
2 Methods 71
3 Results 72
4 Conclusion 74
Acknowledgements 74
References 74
Thermal Regimes of Heart, Myocardium Repolarization and St-T Genesis. A Model Study 75
References 78
III. Heart Rate Regulation and Rhythm Disturbances 79
Heart Rate Control and Hemodynamics During Sleep in Cad Patients with Sleep Apnea Syndrome 81
Introduction 81
Contingent and Methods 81
Results and Discussion 82
Conclusion 84
References 84
Baroreflex Sensitivity and Heart Rate Variability 85
Introduction 85
Contingent and Methods 85
Results 86
Conclusion 88
References 88
Autonomic Heart Rate Control Modifications in Relation to Localisation of Pathological Process in Coronary Artery Disease Patients 89
Introduction 89
Methods and Contingent 89
Results 90
Conclusions 92
References 92
Comparison of Discriminative Ability of Signal Averaged and Single Beat Cardiac Micropotentials in Subjects with/without Myocardial Electrical Instability 93
1 Introduction 93
2 Material and Methods 94
3 Results 95
4 Discussion 96
Acknowledgments 96
References 96
Comparison of the Time-Frequency Mapping of the Signal Averaged ECG Signal Using FFT Algorithm and Wigner Distribution 97
References 99
Comparative Study on Antiarrhythmic Effects of a New Class IC Drug, Pilsicainide and Disopyramide on Patients with Paroxysmal Atrial Fibrillation 100
Introduction 100
Methods 101
Results 101
Discussion 103
References 104
High Resolution ECG in Dogs - Gliding Window Fast Fourier Transform Analysis and Wigner's Transformation 105
1. Introduction 105
2. Material and Methods 106
2.1. High-resolution electrocardiogaphy 106
2.2. Time domain analysis 106
2.3. Frequency domain analysis 106
3. Results 107
4. Conclusions 107
References 108
First Experiences with Radiofrequency Catheter Ablation 109
1 Introduction 109
2 Methods 110
3 Results 110
3.1 Patients with the wolff-parkinson-white syndrome 110
3.2 Slow pathway ablation in patients with AV nodal reentry tachycardia 111
3.3 Atrial fibrillation and miscellaneous tachycardias 111
4 Discussion 112
Acknowledgments 112
References 112
Sinus Node Dysfunction in Children 113
1 Introduction 113
2 Material Nad Methods 113
3 Results 114
Atropine testing 115
Exercise test 115
24 hour Ecg monitoring 115
Transoesophageal stimulation 115
4 Treatment 115
5 Discussion 116
References 116
Autonomic Neuropathy and Hypertension Increase QT Dispersion in Diabetics 117
1. Introduction 117
2. Patients and Methods 118
3. Results 119
4. Discussion 119
5. References 120
Periodicity of Severe Arrhythmias in Chronic Respiratory Failure at Altitude Above 1,000 M 121
Conclusions 124
References 124
Compared Study to Holter-SA-ECG with Left Ventricular Function Using Multiple Gated Acquisition Cardiac Blood Pool Imaging in Patients with Myocardial Infarction 125
Backgrouds and Purpose 125
Patients and Methods 125
Results 126
Conclusion 126
Discussion 128
Acknowledgment 128
References 128
Influence of the Infarct Site on the Identification of Patients with Ventricular Tachycardia after Myocardial Infarction Based on the Time -Domain and Spectral Turbulence Analysis of the Signal- Averaged Electrocardiogram 129
Abstract 129
Introduction 129
Methods 130
Patients 130
Signal-Averaged Electrocardiogram 130
Statistics 131
Results 131
Discussion 132
Conclusion 133
References 133
Signal Averaged Electrocardiogram in Chronic Chagas' Heart Disease 135
Abstract 135
Introduction 135
Patients 136
Methods 136
Results and Discussion 137
Conclusions 139
References 139
Signal-Averaged ECG in the Evaluation of Anthracycline Cardiotoxicity in Survivors of Childhood Cancer 142
1 Introduction 143
2 Patients and Methods 143
3 Results 144
4 Discussion 144
5 Conclusion 145
References 145
IV. Body Surface Potential Mapping 147
Spherical-Quasiepicardium Potential Mapping in Estimation of Surgical Treatment for Wolff-Parkinson-White Syndrome 149
1. Introduction 149
2. Subjects and Methods 149
3. Results and Conclusion 151
Acknowledgements 151
References 151
Noninvasive Localization of Preexcitation Sites Using Experimental BSPM Data 153
1 Background 153
2 Method and Material 154
3 Results and Discussion 155
4 Conclusions 156
References 156
Acknowledgments 156
The Incidence of Multipolar Distribution in the Body Surface QRST Isointegral Maps in Patients with Postinfarction Left Ventricular Aneurysm 157
Introduction 158
Material 158
Methods 159
Results 159
Discussion 160
References 160
Body Surface Potential Mapping of Simulated Retrograde P Waves Around the Atrioventricular Ring in the Dog 166
1 Introduction 166
2 Methods 167
2.1 Canine preparations and experimental protocol 167
2.2 Body surface potential mapping 167
3 Results 167
3.1 P wave potential mapping when P wave is separated from T wave 167
3.2 Comparison of BSPM patterns for different stimulation sites 168
3.3 Influence ofthe T wave during tachycardia 168
4 Discussion 169
Acknowledgements 169
References 169
Cardiac Electric Field on Ventricular Epicardium and Body Surface in the Dog Under Ventricular Endocardial Stimulation 170
1 Introduction 170
2 Methods 170
3 Results 171
3.1 Sequence of the epicardial ventricular depolarization under ectopic excitation 171
3.2 Relationship between potential distributions over torso and ventricular surfaces under ectopic foci in the right ventricle 172
4 Conclusion 173
Cardiac Electric Field on Body Surface in Patients with Implanted Artificial Cardiac Pacemakers 174
1 Introduction 174
2 Materials and Methods 174
3 Results 175
4 Discussion 177
5 Conclusion 177
Properties of Cardiopotential Distribution on Chest Surface in Healthy People at the Period of the Heart Ventricular Depolarization 178
1 Introduction 178
2 Methods 178
3 Results 178
4 Discussion 181
5. Conclusion 181
Comparative Study of the Influence of Somatometric Variables on Vectorcardiographic and Body Surface Mapping Characteristics 182
1. Introduction 182
2. Subjects and Methods 182
3. Results and Discussion 183
3.1 Atrial activation 183
3.2. Ventricular activation 184
3.3 Ventricular repolarization 185
Conclusion 185
References 185
Long-Term Study of Heart Activation Changes Displayed in Body Surface Isochrone Maps with Threshold Potential 186
1 Introduction 187
2 Theoretical Background 187
3 Methods 187
4 Results 188
5 Conclusion 188
Acknowledgement 189
References 189
Arrhythmogenic Substrate for Malignant Arrhythmias Detected by Singular Value Decomposition of Body Surface Potential Maps 190
1 Introduction 190
2 Material and Methods 191
2.1 Study subjects 191
2.2 Body surface potential mapping 191
2.3 Data processing 191
2.4 Statistical analysis 192
3 Results 192
4 Discussion 193
5 Conclusions 193
Acknowledgements 193
References 193
Body Surface Potential Map Database Developed in the Program JUMP 2001 194
1 Introduction 194
2 Method 195
3 Results 196
Acknowledgments 197
References 197
Statistical Validation of the Lux-Type Limited Lead System 198
1. Introduction 198
2. Methods 199
3. Results 200
4. Discussion 201
Acknowledgements 201
References 201
Comparison Study for Examination of the Information Equivalency of the Savard-63 and the Lux-192 Lead Systems 202
1 Introduction 202
2 Materials and Methods 203
3 Results 203
4 Discussion 204
5 Conclusion 204
Acknowledgments 205
References 205
Assessment of Left Ventricular Hypertrophy by QRS Isointegral Maps in Patients with Essential Hypertension 206
Introduction 206
Material 207
Methods 207
Results 208
Discussion 208
References 209
Diagnosis of Non-Q Wave Myocardial Infarction by Isoarea Departure Maps Using Different Time Periods 210
1. Introduction 210
2. Methods 210
3. Results 211
Acknowledgements 213
References 213
Antidepressant Drugs and ECG Body Surface Maps 214
References 217
The Initial QRS Left in Severe Ventricular Pressure Overloading: a Body Surface Potential Mapping Study 218
1 Introduction 218
2 Material and Methods 218
3 Patient Material 219
References 223
Body Surface Mapping Evaluation of Repercussions of the Reductive Ventriculectomy (Batista Operation) on the Electrical Activation of the Heart 224
Abstract 224
Introduction 224
Methods and Materials 225
Study population 225
Body surface mapping 225
Statistical analysis 225
Results 225
Discussion 226
Conclusions 229
References 229
Reference Sample with Appropriately Adjusted Characteristics Improves the Diagnostic Accuracy of Departure Isointegral Maps 231
1. Introduction 231
2. Material and Methods 231
3. Results 233
4. Conclusions 234
5. References 234
The Influence of Thrombolytic Therapy on the Evolution of ST-T Departure Isointegral Bspms in Patients with Acute Myocardial Infarction 235
1. Introduction 235
2. Material and Methods 235
3. Results 236
3.1. DI-BSPMs after successful TL 236
3.2. DI-BSPMs after failed TL or without TL treatment 236
3.3. The clinical relationships (table 1 ) 236
4. Conclusions 238
5. References 238
Electrocardiographic Estimation of Left Ventricular Hypertrophy Regression by Verapamil. a Longitudinal Follow-Up 239
1 Introduction 239
2 Methods 239
3 Results 240
4 Discussion 242
5 Conclusion 242
Acknowledgement 242
References 242
Solution of Direct and Inverse Problems of Electrocardiography Using a Multidipole Model 243
1 Introduction 243
2 Methods and Materials 244
3 Results and Discussion 245
4 Conclusions 246
References 246
V. Computer Assisted Electrocardiography 247
Computerized Analysis of the Spatial Velocity Curve of the T Loop: a New Diagnostic Approach 249
Introduction 249
Methods 250
Populations 250
Results 251
Conclusion 252
References 252
Computerised Exercise Electrocardiogram Analysis System \"Kaunas-Load 253
1. lntroduction 253
2. Patients and Methods 254
3. Results and Discussion 255
4. Conclusions 256
Computerized System for Standard Electrophysiology Studies and Ablation Treatment of the Heart 257
1 Introduction 257
2 System Description 258
3 Results 260
References 260
Computer Assisted Identification of Accessory Pathways from the 12-Lead ECG 261
Abstract 261
1. Introduction 261
2. Materials and Methods 262
3. Results 263
4. Discussion 265
References 265
Comparison of QRS Onset Location Using Neural Networks and Conventional Methods 266
Abstract 266
1. Introduction 266
2. Materials and Method 267
2.1. CSE Reference library 267
2.2. The training and test set 267
2.3. Training the neural network 268
2.4. Testing the neural network 270
3. Results 270
4. Discussion 271
References 271
Possibilities of Evaluation of Heart Functional State in Disabled Patients with Computerized ECG Analysis System 272
1. Introduction 272
2. Methods 272
3. Results and Discussion 273
References 275
VI. Clinical Electrocardiogrpahy, Vectorcardiography, and Dipolar Electrocardiotopography 277
Factors Affecting the Spatial Angle Between Integral QRS and T Vectors 279
Introduction 279
Subjects and Methods 280
Results 280
Conclusions 282
References 282
Analysis of Pre and Post-Operative Electrocardiographic Findings of Patients Submitted to the Reductive Ventriculectomy (Batista Operation) 283
Abstract 283
Introduction 284
Methods and Material 284
Study population 284
Standard 12-lead ECG 285
Results 285
Pre-op findings 285
Post-op findings 285
Discussion 286
Conclusions 288
References 288
Analysis of Pre and Post-Operative Vectorcardiographic Findings of Patients Submitted to the Reductive Ventriculectomy (Batista Operation) 290
Abstract 290
Introduction 290
Methods and Material 291
Results 291
Discussion 293
Conclusion 295
References 295
Decarto Technique in Recognition of Inferior Myocardial Infarction and Localized LVH Indistinguishable by Standard Criteria 297
1. Introduction 297
2. Subjects and Methods 297
3. Results and Conclusion 298
Acknowledgements 300
References 300
The QRS Complex Configuration in Patients with Acute Myocardial Infarction: its Clinical Significance and Anatomical Correlation 301
Abstract 301
Introduction 301
Methods 302
Results 303
Discussion 304
References 305
Statistical Recognition of Right Ventricular Enlargement on the Basis of Decartograms 307
1. Introduction 307
2. Subjects and Methods 307
3. Results 308
4. Discussion 310
5. Conclusion 310
References 310
Assessment of Myocardial Viability with Electrocardiographic St-Segment Changes Induced by Low-Level Exercise 311
Introduction 311
Methods 311
Results 312
Discussion 314
References 315
Reversible Decrease of Depth of Q-Waves from Previous Infarction During Exercise Testing Due to Myocardial Ischemia of the Area Opposite to the Necrosis: a New Diagnostic Index of Ischemia 316
References 319
Diagnostic Efficacy of Seismocardiography and Electrocardiography for the Diagnosis of Coronary Artery Disease During Veloergometric Test 320
1. Introduction 320
3. Results and Discussion 321
2. Methods and Materials 322
References 323
Electrical Alternan Detection During Exercise Testing 324
1 Introduction 324
1.1 Alternans mechanism 324
1.2 Alternans measurement 325
2 Methods 325
2.1 Data source 325
2.2 The alternans analysis technique 325
3 Results 326
4 Discussion 327
5 Conclusion 327
Acknowledgements 327
References 327
Exercise Vectorcardiogram or Treadmill Exercise Electrocardiogram Versus Thalium-201 Single-Photon Emission Computed Tomogram in the Diagnosis of Myocardial Ischaemia 328
1 Introduction 328
2 Methods 328
3 Results 329
4 Discussion 330
Acknowledgments 331
References 331
The Clinical Significance of the Abnormality of St-T Segment in the Ambulatory ECG Recordings at Rest ....... Comparison with the Results of Stress ECG, Echocardiography and Coronary Arteriography 332
Background and Purpose 332
Subjects and Methods 332
Results 333
Discussion 335
Conclusion 335
References 335
Localization of Coronary Artery Narrowings by Exercise-Induced Change of Electrical Axis and St Depression with R-Wave Amplitude Correction in Singlevessel Coronary Artery Disease 336
1 Background 336
2 Methods 336
2.1 Study population 336
2.2 Exercise testing 337
2.3 Axis change 337
2.4 ST depression with R-wave amplitude correction 337
2.6 Statistical analysis 338
3 Result 338
3.1 Axis change 338
3.2 The lead of maximal ST depression 338
4 Discussion 338
References 339
Comparison of the Variability of Specific Potential and Left Ventricular Mass in Congenital Aortic Stenosis 340
1 Introduction 340
2 Material and Methods 341
3 Results and Discussion 342
Acknowledgment 343
References 343
VII. Electrocardiologic Monitoring of Myocardial Rejection 345
Influence of Circadian Rhythm on Intramyocardial Electrograms for Non-Invasive Rejection Monitoring After HTX 347
1 Introduction 347
2 Materials and Methods 348
2.1 Transplant procedure, pacemaker implantation and patient management 348
2.2 CHARM data aquisition, rejection and infection sensitive parameters 348
3 Results 349
3.1 System configuration 349
3.2 Clinical studies 349
3.3 Influence of circadian rhythm and pacing frequency on the rejection sensitive parameters 350
4 Discussion and Conclusion 352
References 353
The Possibilities of Using the Wigner's Transformation of HR ECG for Non-Invasive Detection of Acute Graft Rejection After Heart Transplantation 354
1. Introduction 354
2. The Set of Patients and Methods 355
2.1. EGG, HR EGG signal recording 355
2.2. Time domain analysis 355
2.3. Gliding window fast fourier transform analysis 355
2.4. Time and frequency domain analysis 355
2.5. Wiegner's transformation 355
3. Results 355
4. Conclusions 356
References 356
High-Resolution ECG as a Part of Complex Care for Patients after Orthotopic Heart Transplantation a Case Report 357
1 Introduction 357
2 Case Report 358
3 Results 358
4 Discussion 359
5 Conclusion 359
6 References 360
VIII. Standards for Core ECG Laboratories 361
ECG Core Labs 363
Coding of Serial ECG Changes using an Adaption of the Novacode for Q-Wave Myocardial Infarction in a Large Multicenter Clinical Trial: the Bypass Angioplasty Revascularization Investigation Experience 365
Abstract 365
Introduction 366
Serial Comparison Program 366
Results 366
Frequency of Override Rules 367
Discussion 367
References 368
Experience with a Core ECG/VCG Laboratory in Slovakia 369
Acknowledgment 371
References 371
ECG Analysis Beyond Core Lab Duty Experience from Three Scandinavian Trials 373
Abstract 373
Improved Identification of Acute Myocardial Infarction with 16-Lead ECG 376
1. Introduction 376
2. Methods 377
3. Results 378
4. Discussion 379
Acknowledgments 379
References 379
Recommendations for Consistent Placement of the Chest Electrodes in Clinical Trials and Epidemiological Studies 380
1 Background 380
2 Training of ECG Technicians 380
3 Placement of Limb Electrodes 381
4. Placement of Chest Electrodes 381
4.1 Electrodes V1 and V2 381
4.2 The level of V4, V5 and V6 381
4.3 Left midaxillary line and the location of V6 382
4.4 Locations of V4, V3 and V5 382
3.5 Locations of V4, V3 and V5. alternative method 382
Discussion 382
References 383
Coding Experience at the Glasgow Core ECG Laboratory 384
1. Introduction 384
2. Methods 384
3. Collaborative Studies 387
4. Coding Problems 387
5. Discussion 387
6. Recommendations 388
References 388
Bratislava Resolution 389
Author Index 391