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Physiology: Prep Manual for Undergraduates

Physiology: Prep Manual for Undergraduates

Vijaya D Joshi | Sadhana Joshi Mendhurwar

(2014)

Additional Information

Book Details

Abstract

The Fifth Edition of this book is a must-have for all undergraduate medical students as it prepares them for both theory and viva-voce examinations. It is also useful for paramedical, dental, homeopathy and ayurveda students, besides those preparing for PG entrance examinations. It covers entire syllabus of physiology laid down by the Medical Council of India and health universities across the country.

Salient Features

  • Systemize presentation of text in Question-Answer format helps in revision and self-assessment before examination
  • Extensively revised, updated, and strengthened to keep up with the latest changes in the standard books of physiology
  • Thoroughly revised topics like blood; nerve and muscle; cardiovascular system; and central nervous system
  • Large number of diagrams, tables and flowcharts to facilitate quick learning and greater retention of knowledge

Table of Contents

Section Title Page Action Price
Front cover Cover
Physiology prep manual for undergraduates fifth edition iii
Copyright Page iv
Dedication v
Foreword vii
Preface to the fifth edition ix
Preface to the first edition x
Table of contents xi
1 The cell and general physiology 1
Cell and cell organelles 1
Cell division 2
Cell death 5
Homeostasis 5
Transport across the cell membrane 8
Simple diffusion 10
Facilitated diffusion 11
Active transport 14
Primary active transport 14
Secondary active transport 16
Pinocytosis and phagocytosis 17
Osmosis and osmotic pressure**For details refer Vaz M, Kurpad A, Raj T, editors. Guyton & Hall Textbook of Medical Physiol ... 19
Resting membrane potential 19
2 Blood 23
Body fluids 23
Measurements of volumes of different fluids 24
Blood 28
Blood volume 29
Blood ph 32
Plasma proteins 33
Non-protein nitrogenous substances 36
Blood cells 36
Red blood cells 36
Haemoglobin 42
Metabolism of b12 44
Metabolism of iron 45
Anaemia 46
Polycythaemia 49
Life span and fate of rbc 49
Fragility 50
ESR 51
Jaundice 52
White blood cells 53
Formation of wbcs 58
Abnormalities 59
Platelets 63
Clotting of blood 65
Anticoagulants 71
Diseases 72
Methods for determination of defects in blood clotting 72
Clot lysis 73
Blood groups 73
Blood transfusion 75
Rh blood group system 78
Lymphatic system 79
3 Immunity 83
Introduction 83
Classification 83
Non-specific immunity 84
Specific immunity 85
Humoral immunity 85
Cell-mediated immunity 89
Factors affecting resistance to infection 92
Allergy 92
AIDS 93
4 Digestion and absorption 94
Introduction 94
Gastrointestinal tract (gi tract) 94
Mastication 96
Salivary glands 97
Deglutition 101
Anatomy of stomach 103
Functions of stomach 103
Motor functions 103
Enumerate the motor functions of stomach. 103
Describe the storage function of stomach. 104
What is chyme? how is it formed? 104
What is basic electrical rhythm of stomach? 104
Describe the mixing waves of stomach. 104
Describe the emptying of stomach. 104
Control of pyloric sphincter 105
Enumerate the factors regulating the emptying of stomach. 106
What is the purpose of enterogastric reflex? 106
What are hunger contractions? 107
How are the movements of stomach studied in man? 107
Vomiting 107
Secretory function 107
Small intestine 116
Structure 116
Describe the structure of the small intestinal mucosa. 116
Describe the structure of villus. 116
Where are the brunner’s glands located? what is their function? 116
Secretion 117
Movements 118
Pancreas 120
Bile 123
Large intestine 128
Digestion and absorption 129
5 Excretory system 135
Introduction 135
Structure of nephron 136
Blood flow to kidneys 138
Formation of urine 140
Glomerular filtration 140
Reabsorption 146
Secretion 150
Tubular load, tubular maximum 150
Plasma clearance 151
Formation of dilute or concentrated urine 153
Regulation of electrolyte balance 153
Regulation of ph of body fluids 159
Renal function tests 165
Micturition 166
Dialysis 169
6 Temperature regulation 170
Introduction 170
Mechanisms of heat production 171
Mechanisms of heat loss 171
Regulation of body temperature 173
Abnormalities in temperature regulation 176
Skin and its functions 177
7 Respiratory system 179
Introduction 179
Pulmonary circulation 182
Mechanism of respiration 184
Pulmonary pressures 186
Intrapleural pressure 186
What is intrapleural pressure? how is it measured? 186
State the variation that occurs in intrapleural pressure during normal tidal respiration. 186
What is the cause of negativity of intrapleural pressure? 187
What is surface tension? what is its effect on the lungs? 187
What is a surfactant? what is its action? 187
Name the surfactant present in the lungs. what are its functions? 187
What are the functions of surfactant? 188
Functions of surfactant 188
What is respiratory distress syndrome? 189
What is atelectasis? 189
What is adult respiratory distress syndrome? 189
What are the effects of intrapleural pressure on cardiovascular system? 189
Under what circumstances does intrapleural pressure become positive? 190
Intra-alveolar pressure 190
What is intra-alveolar pressure? how does it vary during normal tidal respiration? 190
When is alveolar pressure equal to atmospheric pressure? 190
Transpulmonary pressure 190
What is transpulmonary pressure? 190
Applied aspect 190
What is pleural effusion? 190
What is pneumothorax? 190
Compliance 191
Applied aspect 192
Work of breathing 192
Ventilation 194
Dead space air 199
Alveolar ventilation 201
Va/q ratio 201
Applied aspect 203
Diffusion of gases 204
Respiratory membrane 204
Describe the respiratory membrane. 204
Factors affecting diffusion of gases 205
Describe the factors affecting gaseous exchange at the respiratory membrane. 205
In which diseases diffusion of gases across the respiratory membrane would suffer? 206
What is venous admixture? 207
Diffusing capacity of lungs 207
Transport of gases 207
Transport of carbon dioxide 212
Respiratory exchange ratio 214
Applied aspect 215
Regulation of respiration 215
Nervous regulation 216
Chemical regulation 218
Periodic breathing 221
Important respiratory reflexes 222
Receptors in the airway 222
Terms used for altered respiration 223
Hypoxia 224
Acclimatization 226
Mountain sickness 227
Hyperbaric oxygen therapy 228
Cyanosis 228
Artificial respiration 229
Exposure to low atmospheric pressure 229
Exposure to high atmospheric pressure 229
Cardiorespiratory changes during exercise 230
8 Special senses 234
Vision 234
Eye 234
State the functions of lacrimal secretion. 234
Name the different tunics (coats) of the eyeball. 234
What is lamina cribrosa? 234
Why can cornea be successfully transplanted? 234
How does cornea obtain its nutrition? 234
Describe the structure of ciliary body. 235
What is pupil? 235
What are the muscles present in the iris? 235
What is the function of the iris? 236
How is the amount of light entering the eye controlled? 236
What is spherical aberration? 236
What is chromatic aberration? 236
What is depth of focus? 236
What is diffraction of light? 237
What is cataract? 237
What is the treatment of cataract? 237
Aqueous humour 237
What is aqueous humour? how is it formed? what is its composition? 237
What are the functions of aqueous humour? 237
How is aqueous humour circulated? 237
What is intraocular pressure? how is it measured? how much is it normally? 238
What is glaucoma? 238
Vitreous humour 238
What is vitreous humour? what is its function? 238
Refraction 238
What is refractive index? 238
What is refraction? 238
Enumerate the different types of lenses. 239
What is the main difference between convex and concave lenses? 239
What is the difference between spherical and cylindrical lenses? 239
What is the focal length of the lens? 239
How do you express the refractive power of the lens? 239
Name the different refractive media of the eye with their refractive indices. 239
Name the different refractive surfaces of the eye and their refractive powers. 240
At which refractive surface in the eye maximum refraction occurs and why? 240
What is the refractive power of the lens of the eye when it is taken out? why? 240
What is reduced eye? 240
What is nodal point? where does it lie in normal eye? 240
Errors of refraction 240
What is emmetropia? 240
Name the different refractive errors of the eye. 241
Pathological errors 241
Physiological errors 241
What is myopia or short sightedness? what are its causes? 241
What are the far point and near point for myopic person? 241
How is myopia corrected? 241
What is hypermetropia or far sightedness? 241
What are the causes of hypermetropia? 242
Where is the far point and near point for hypermetropic person? 242
How is hypermetropia corrected? 242
What is astigmatism? what is it due to? 242
How is astigmatism corrected? 242
Why is cylindrical lens used for correcting astigmatism? 242
How is plane of abnormal component of the astigmatic lens determined? 243
What are contact lenses? what are their advantages and disadvantages? 243
Advantages 243
Disadvantages 243
Accommodation 244
What is accommodation? 244
How is the eye accommodated for far vision? 244
What is the effect of contraction of ciliary muscles? 244
How is the eye accommodated for near vision? 244
How is the contraction of ciliary muscles controlled? 244
What is far point? 245
What is near point? 245
What is the range of accommodation? 245
What is the amplitude of accommodation? 245
What are the other changes occurring during accommodation for near vision in addition to increased refractive power of the ... 245
What is the benefit of constriction of pupil occurring during accommodation of eye for near vision? 245
What is presbyopia? 245
How is presbyopia treated? 246
During accommodation for near vision which surface of the lens becomes more globular? 246
Visual acuity 246
Depth perception 247
Retina 248
Receptors 250
Photochemistry of rods 251
Photochemistry of cones (colour vision) 253
Dark and light adaptation 255
Neuronal connections in retina 257
Visual pathway 259
Field of vision 263
Muscles of eye and eye movements 266
Pupillary reflexes 268
Horner’s syndrome 269
Hearing 270
Introduction 270
What is the sound frequency range to which human ear is sensitive? 270
Name the different parts of the ear. 270
Structure and functions of external (outer) and middle ear 270
Structure and functions of inner ear (cochlea) 272
Auditory pathway 279
Deafness 281
Taste 283
Smell 286
Equilibrium 289
Structure and functions of vestibular apparatus 289
Name the different parts of vestibular apparatus. 289
What are the sense organs present in vestibular apparatus? 289
What are the stimuli for sense organs in vestibular apparatus? 289
What is the function of maculae of utricle and saccule? 289
What is the function of crista of semicircular canal? 289
Describe macula. 290
What are the functions of macula? 290
Describe the positions of semicircular canals. 290
Describe the sense organ present in semicircular canals. 290
How is the sense organ in semicircular canals stimulated? 291
What is the function of semicircular canals? 292
Vestibular pathway 292
Nystagmus 293
Vestibular function tests 293
9 Endocrinology 294
Introduction 294
Hormones 295
Anterior pituitary gland 299
Growth hormone 300
Applied 302
Posterior pituitary gland 303
Thyroid gland 305
Actions of thyroid hormones 307
Regulation of thyroid hormones 311
Thyroid function tests 312
Applied 313
Adrenal cortex and medulla 315
Adrenal medullary hormones 316
Applied 318
Adrenocortical hormones 319
Mineralocorticoids 320
Regulation 321
Glucocorticoids 322
Regulation 324
Other hormones 325
Applied 326
Pancreas 327
Insulin 327
Actions of insulin 328
Regulation 330
Applied 331
Glucagon 333
Actions of glucagon 333
Regulation 334
Somatostatin 334
Parathyroid 335
Calcium and phosphate metabolism 335
Describe the intestinal absorption of calcium and phosphate. 335
How are calcium and phosphate excreted? 335
What is the role of vitamin D in calcium and phosphate absorption? 335
What are the various forms in which calcium is present in plasma? state the concentration of calcium in plasma. 336
What are the various forms of inorganic phosphate in plasma? state the concentration. 336
Composition and formation of bone 336
Parathyroid hormone 338
Actions 339
Regulation 340
Vitamin D 340
Calcitonin 340
Control of calcium ion concentration 341
Tetany 341
Hypercalcaemia 342
Hypo- and hyperparathyroidism 343
Rickets 344
Osteomalacia 344
Osteoporosis 344
10 Reproduction 345
Male reproductive system 345
Male sex organs 345
Describe the anatomy of male sex organs. 345
Spermatogenesis 345
Seminal vesicles and prostate 349
Semen 349
Capacitation 350
Fertilization of ovum 350
Effect of temperature on spermatogenesis 350
Hormones of testis 351
Puberty and male climacteric 354
Female reproductive system 354
Female sex organs 354
Describe the anatomy of female sex organs. 354
Hormones 355
Menstrual cycle 355
Ovarian hormones 361
Pregnancy 364
Parturition 369
Lactation 369
Circulatory changes at birth 370
Contraception 371
11 Nerve and muscle 373
Nerve 373
Introduction and classification 373
How much is the resting membrane potential of the nerve fibre? 373
Give the classification of nerve fibres. 373
1. structurally 373
2. depending on their origin 373
3. functionally 373
4. depending on the neurotransmitter they secrete at their endings 373
5. general classification 373
6. sensory classification 374
Stimulus 374
Initiation of action potential 375
Propagation of action potential 376
Recording of action potential 378
Properties of nerve fibre 381
Degeneration of nerve 383
Reaction of degeneration 384
Muscle 385
Introduction 385
What is muscle? 385
Name the different types of muscles. 385
Which is the most excitable muscle? 385
Structure of skeletal muscle 385
Excitation-contraction coupling 388
Muscle contraction 389
Energetics of muscle contraction 392
Muscle tension 393
Types of skeletal muscle fibres 396
Properties of skeletal muscle 397
Tetanus 398
Fatigue 398
Common terms used 400
Emg 401
Neuromuscular junction 402
Structure 402
How is the muscle normally activated? 402
Describe the structure of neuromuscular junction. 402
Transmission of impulse 402
Drugs affecting neuromuscular junction 403
Myasthenia gravis 404
Muscle rigour 404
Functions of skeletal muscles 404
Comparison of skeletal, cardiac and smooth muscle 405
Smooth muscle 410
12 Cardiovascular system 411
Introduction 411
Cardiac muscle 413
Initiation and conduction of cardiac impulse 414
Applied aspect 419
Nervous control of heart rhythm 419
Cardiac cycle 420
Heart sounds 427
Electrocardiogram 429
Abnormalities in rate and rhythms* 436
Haemodynamics 436
Pulse 441
Venous system 441
Capillary system 444
Control of blood flow 445
Nervous control of blood flow 448
Blood pressure 448
Vasomotor centre 449
Short-term mechanisms regulating blood pressure 451
Long-term mechanisms regulating blood pressure 455
Cardiac output 457
Shock 460
Regulation of blood flow through skeletal muscle 463
Heart rate 464
Cardiac failure**For details refer Vaz M, Kurpad A, Raj T, editors. Guyton & Hall Textbook of Medical Physiology. Elsevier ... 465
Coronary circulation 467
Cerebral circulation 471
Pulmonary circulation—refer to respiratory system 473
13 Central nervous system 474
Introduction 474
Levels of cns function 474
Types of cells in nervous system 475
Nerve–fibres classification 477
Definition 477
Types 477
Structure 478
Synaptic transmission 479
Epsp 479
Ipsp 480
Properties of synapse 481
Neurotransmitters 484
Important neurotransmitters 485
Sensory system 486
Introduction 486
What is sensory system or sensory division of cns? 486
Classification of sensations 486
How are the sensations classified? 486
Receptors 487
Definition 487
What are receptors? 487
Classification 487
How are receptors classified? 487
Properties 488
Describe the properties of receptors. 488
State the differences between receptor potential and action potential. 489
Receptor potential 489
Describe the mechanism by which receptor potential develops. 489
What is sensory unit? 490
What is receptive field? 490
Cutaneous sensations 490
Enumerate the cutaneous sensations. which type of sensory fibres encodes these sensations? 490
Name the tactile receptors. 490
Sensory pathway 491
Ascending tracts 491
Name the pathways of transmission of different sensations. 491
Describe the dorsal column-medial lemniscal pathway. 491
What are the main functions of dorsal column-medial lemniscal system? 493
Describe the effects of damage to the dorsal column pathway. 493
Describe the anterolateral pathway for transmission of sensory impulses to the cortex. 493
What are the characteristics of transmission in anterolateral pathway? 495
Write the differences between dorsal column and anterolateral pathways. 495
Physiology of pain 496
Reflexes 501
Classification 501
Study of reflexes 502
Properties of reflex action 502
Important reflexes 504
Stretch reflex 504
What is stretch reflex? 504
What is a muscle spindle? 504
Describe the structure of muscle spindle. 504
When are the muscle spindles stimulated? 505
What is the dynamic stretch reflex? 506
Describe the static stretch reflex. 506
What is negative stretch reflex? 506
Describe the reflex arc for stretch or myotatic reflex. 506
Explain the role of gamma efferents. 506
Functions of stretch reflex 508
What are the functions of stretch reflex? 508
Applied aspect 508
What is hypotonia? when does it occur? 508
What is hypertonia? when does it occur? 508
What is clonus? 509
Golgi tendon reflex 509
What are golgi tendon organs? what is golgi tendon reflex? 509
What are the functions of golgi tendon reflex? 509
Withdrawal reflex 509
Describe the withdrawal reflex. 509
Difference in mono and polysynaptic reflex 510
Differentiate between monosynaptic reflex and polysynaptic (multisynaptic) reflex. 510
Spinal cord 510
Spinal reflexes 512
Motor system 513
Introduction 513
What is motor system or motor division of cns? 513
Where is the motor cortex? how is it divided? 514
What is broca’s area? 514
Descending tracts 514
Pyramidal (corticospinal tract) 514
Describe the corticospinal tract. 514
What are the functions of pyramidal or corticospinal tract? 516
What is the effect of lesion of the pyramidal tract? 516
Extrapyramidal tracts 516
What is extrapyramidal system? 516
Describe the rubrospinal tract. what is its function? 516
Describe the reticulospinal tracts. 517
Describe the vestibulospinal tracts. 518
Describe the tectospinal tract. 518
Describe the olivospinal tract. 518
Describe the interstitialspinal tract. 519
Difference between lateral and medial motor system 519
Difference between pyramidal and extrapyramidal system 519
Transection of spinal cord 520
Brain stem 523
Muscle tone 525
Abnormalities 527
Posture and equilibrium 528
Decorticate preparation 531
Hypothalamus 531
Structure 531
Describe the structure of hypothalamus. 531
Connections 532
Functions 533
Limbic system 535
Reticular formation 537
Thalamus 537
Structure 537
Describe the structure of thalamus.refer 537
Connections 540
Describe the connections of thalamus. 540
Functions 541
Describe the functions of thalamus. 541
Functions of thalamus in man 541
Applied aspect 541
What is thalamic syndrome? 541
Basal ganglia 542
Structure 542
Describe the anatomy of basal ganglia. 542
Connections 542
Describe the connections of basal ganglia. 542
Afferent connections 542
Efferent connections 544
Neuronal circuits (fig. 13.24) 544
Connections of substantia nigra 545
Connections of subthalamic nucleus 545
Functions 545
Describe the functions of basal ganglia. 545
1. voluntary motor activity 545
2. control of reflex muscular activity 546
3. control of muscle tone 546
Effects of damage**For details refer Vaz M, Kurpad A, Raj T, editors. Guyton & Hall Textbook of Medical Physiology. Elsevi ... 546
What are the effects of the damage to the basal ganglia? 546
Cerebellum 547
Structure 547
Describe the structure of cerebellum. 547
Why cerebellum is called silent area? 550
Connections 550
Describe the connections of cerebellum. 550
Structural unit 553
Describe the functional unit of cerebellum. 553
What is delay line negative feedback signal? 553
Functions**For details refer Vaz M, Kurpad A, Raj T, editors. Guyton & Hall Textbook of Medical Physiology. Elsevier: New ... 554
Describe the functions of cerebellum. 554
Functionally cerebellum is divided into: 554
Functions of vestibulocerebellum 554
Functions of spinocerebellum 554
Functions of cerebrocerebellum 555
Planning of sequence of movements 555
Cerebellar damage**For details refer Vaz M, Kurpad A, Raj T, editors. Guyton & Hall Textbook of Medical Physiology. Elsevi ... 556
Describe the features of cerebellar damage. 556
Cerebral cortex 557
Structure 557
Describe the structure of cerebral cortex. 557
Different lobes 557
Control of voluntary movements 558
Frontal lobe 559
Connections and functions 559
Describe the connections and functions of frontal lobe. 559
1. Precentral cortex 559
Connections of precentral cortex 560
2. Prefrontal cortex (orbitofrontal cortex) 561
Connections of prefrontal cortex 562
Describe the functions of parietal lobe. 563
Occipital lobe 563
Connections and functions 563
Describe the connections and functions of occipital lobe. 563
Temporal lobe 564
Connections and functions 564
Describe the connections and functions of temporal lobe. 564
Dominant hemisphere 564
Higher functions 565
Speech 565
What is speech? 565
Describe the sensory aspect of communication. 565
Describe the motor aspect of communication. 565
Learning 566
What is learning? explain the different forms of learning. 566
Conditioned reflex 567
What is conditioned reflex? 567
What is the importance of conditioned reflex? 567
Describe the characteristic features of conditioned reflex. 567
Memory 568
What is memory? 568
How do you classify memory? 568
What is the mechanism of short-term memory? 568
What is the neural mechanism of intermediate long-term memory? 569
What is the mechanism for long-term memory? 569
Memories placed into longer-term 570
What is retrograde amnesia? 570
What is anterograde amnesia? 570
Eeg 570
What is electroencephalogram? how is it recorded? 570
Name the different types of waves recorded in eeg. 571
Sleep 571
Csf 574
Blood-brain and blood-csf barrier 575
Autonomic nervous system 575
Index 579
A 579
B 579
C 580
D 581
E 581
F 582
G 582
H 582
I 583
J 583
L 583
M 584
N 584
O 585
P 585
Q 586
R 586
S 586
T 587
U 588
V 588
W 588
Z 588